APPLICATION_ID,ACTIVITY,ADMINISTERING_IC,APPLICATION_TYPE,ARRA_FUNDED,AWARD_NOTICE_DATE,BUDGET_START,BUDGET_END,CFDA_CODE,CORE_PROJECT_NUM,ED_INST_TYPE,FOA_NUMBER,FULL_PROJECT_NUM,FUNDING_ICs,FUNDING_MECHANISM,FY,IC_NAME,NIH_SPENDING_CATS,ORG_CITY,ORG_COUNTRY,ORG_DEPT,ORG_DISTRICT,ORG_DUNS,ORG_FIPS,ORG_NAME,ORG_STATE,ORG_ZIPCODE,PHR,PI_IDS,PI_NAMEs,PROGRAM_OFFICER_NAME,PROJECT_START,PROJECT_END,PROJECT_TERMS,PROJECT_TITLE,SERIAL_NUMBER,STUDY_SECTION,STUDY_SECTION_NAME,SUBPROJECT_ID,SUFFIX,SUPPORT_YEAR,TOTAL_COST,TOTAL_COST_SUB_PROJECT
8647621,F30,HL,1,N,01/15/2014,01/15/2014,01/14/2015,837,F30HL118775,SCHOOLS OF MEDICINE,PA-11-110,1F30HL118775-01A1,NHLBI:34188\,"Training, Individual",2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,NONE,07,047006379,US,HARVARD UNIVERSITY (MEDICAL SCHOOL),MA,02115,"PUBLIC HEALTH RELEVANCE: Diabetes roughly doubles the risk of myocardial infarction, stroke, and congestive heart failure, and quadruples the risk of peripheral artery disease (PAD). This projects aims to understand why diabetes elevates the risk of PAD and to investigate fibrosis as a potential area of interest for PAD prevention and treatment. For the proposed research, we will place specific emphasis on mechanistic insights and correlation of biomarkers with disease pathogenesis.            ",11415720;,"AGARWAL, ISHA;","MEADOWS, TAWANNA ",01/15/2014,08/31/2017,Accounting;adjudication;Adult;Affect;Age;aged;American;Ankle;Area;Arteries;Atherosclerosis;Basic Science;Biological Markers;Blood flow;blood glucose regulation;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;Clinical;cohort;Complications of Diabetes Mellitus;Congestive Heart Failure;Cox Proportional Hazards Models;Data;Diabetes Mellitus;diabetic;Disease;Disease Association;disorder prevention;Elderly;Epidemic;Epidemiology;Event;Exercise;experience;Fasting;Fibrosis;follow-up;Frequencies (time pattern);Gangrene;Glucose;Glucose Intolerance;Goals;Health;high risk;Hour;human old age (65+);improved;indexing;Individual;insight;insulin secretion;insulin sensitivity;interest;Laboratories;Lead;Life Style;limb amputation;Limb structure;Linear Regressions;Link;Measurement;Measures;Mediating;Medicine;men;Mentorship;Methods;Mission;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oral;Outcomes Research;Pain;Pathogenesis;Pathway interactions;Patients;Peripheral;Peripheral arterial disease;Phenotype;Physicians;Plasma;population based;Prevalence;Prevention;procollagen Type III-N-terminal peptide;programs;prospective;public health relevance;Relative (related person);Research;Research Personnel;Research Project Grants;Research Training;Risk;Role;Scientist;Severities;skills;stroke;Time;Training Programs;Ulcer;waist circumference;Woman;Writing,The role of diabetes in fibrosis and peripheral artery disease,118775,ZRG1,Special Emphasis Panel,,A1,1,34188,
8648411,F31,AI,1,N,01/21/2014,01/06/2014,01/05/2015,855,F31AI106288,SCHOOLS OF MEDICINE,PA-11-112,1F31AI106288-01A1,NIAID:32129\,"Training, Individual",2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BIRMINGHAM,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,063690705,US,UNIVERSITY OF ALABAMA AT BIRMINGHAM,AL,35294,"PUBLIC HEALTH RELEVANCE: Biofilm formation is involved in cholera transmission and in survival of pathogenic Vibrio cholerae in aquatic environments. With this research effort, we will determine the mechanism by which a bacterial regulator, known as the histone-like nucleoid structuring protein, modulates this process.            ",11497984;,"AYALA-FIGUEREDO, JULIO C;","ADGER-JOHNSON, DIANE S.",01/06/2014,01/05/2018,"Acids;activating transcription factor;Acute;Address;Africa;Anabolism;Architecture;Area;Asia;Binding (Molecular Function);Biocide;Biological Assay;bis(3',5')-cyclic diguanylic acid;cell motility;Cells;Cessation of life;Cholera;Cholera Toxin;chromatin immunoprecipitation;Communities;Complex;Confocal Microscopy;Development;Diarrhea;Disease;Disease Outbreaks;Disinfectants;DNA;DNA Sequence;DNA-Binding Proteins;DNase-I Footprinting;Electrophoresis;Electrophoretic Mobility Shift Assay;Environment;Exhibits;Extracellular Matrix;Feces;Gene Expression;gene repression;Genes;Genetic;Genetic Programming;Genetic Transcription;Goals;Gram-Negative Bacteria;Histones;In Vitro;in vivo;Intestines;Kinetics;LacZ Genes;Laser Scanning Confocal Microscopy;Microbial Biofilms;Molecular;Molecular Biology;Mus;mutant;novel;Occupations;Operon;Oral;Pattern;Phenotype;Pilum;Plankton;Polysaccharides;Prevalence;Prevention;Process;Prokaryotic Cells;Promotor (Genetics);Property;protein structure;public health medicine (field);public health relevance;quorum sensing;receptor;Regulation;Repression;Research;Resistance;Rice;Role;Route;second messenger;Second Messenger Systems;Severities;Signal Transduction;Staging;Stomach;Stress;Suspension substance;Suspensions;Swimming;Testing;Toxin;transcription factor;Transcription Initiation;transmission process;trend;Vibrio;Vibrio cholerae;Vibrio cholerae O1;Virulence Factors;Water;waterborne",Regulation of Vibrio Biofilm Formation by H-NS Repression and Anti-repression.,106288,ZRG1,Special Emphasis Panel,,A1,1,32129,
8645097,F31,AI,1,N,01/15/2014,02/01/2014,01/31/2015,855,F31AI110046,SCHOOLS OF MEDICINE,PA-11-112,1F31AI110046-01,NIAID:34099\,"Training, Individual",2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,BIOLOGY,07,047006379,US,HARVARD UNIVERSITY (MEDICAL SCHOOL),MA,02115,"PUBLIC HEALTH RELEVANCE: Further work to uncover the function of bacterial cell envelope genes of unknown function will broaden our knowledge of cell wall biogenesis in bacteria, an understanding that is crucial to sustain the on-going search for new targets for new and effective antibiotics. The proposed project will contribute to this effort by exploring the function and regulation of YceG, a novel cell wall hydrolase in E. coli.            ",9518509;,"YUNCK, RACHEL E;","ADGER-JOHNSON, DIANE S.",02/01/2014,01/31/2017,Anti-Bacterial Agents;Antibiotics;Bacteria;base;Biochemical;Biogenesis;Bioinformatics;cell envelope;Cell membrane;Cell Wall;Cells;Cleaved cell;Complex;crosslink;Cytolysis;Development;Digestion;Ensure;Enzymes;Escherichia coli;Future;Generations;Genes;Genetic;Genetic Screening;Goals;Gram-Positive Bacteria;Growth;Hydrolase;In Vitro;in vivo;insight;Knowledge;Lactams;Lead;Lesion;Light;liquid chromatography mass spectrometry;Lytic;Membrane;Morphogenesis;N-Acetylmuramoyl-L-alanine Amidase;Normal Cell;novel;Penicillin-Binding Proteins;Penicillins;Peptides;Peptidoglycan;Phenotype;Physiological;Polysaccharides;Process;Proteins;public health relevance;Recycling;Regulation;research study;Role;Rupture;small molecule;Specificity;Stress;Structure;Time;Work,Dissecting the role of YceG in E. coli cell wall biogenesis,110046,ZRG1,Special Emphasis Panel,,,1,34099,
8647598,F31,MH,1,N,09/16/2013,01/01/2014,12/31/2014,242,F31MH102888,SCHOOLS OF ARTS AND SCIENCES,PA-11-111,1F31MH102888-01,NIMH:36079\,"Training, Individual",2013,NATIONAL INSTITUTE OF MENTAL HEALTH,,NASHVILLE,UNITED STATES,PSYCHOLOGY,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212,"PUBLIC HEALTH RELEVANCE: The research goal of the proposed project is to improve our understanding of how individual differences in reward sensitivity influence reward seeking behavior by determining how these traits change the way we use cognitive processes like memory and attention when rewards are at stake. Understanding these processes will allow us to better understand the basic relationship between reward and behavior as well as reward related deficits in disorders such as addiction, depression, and schizophrenia. The training goal of this proposal is to develop the ability to integrate cutting edge affective and cognitive neuroscience to answer questions about individual differences in personality, behavior, and psychopathology.            ",11597183;,"HERITAGE, ALLAN JAMES;","ROSEMOND, ERICA K",01/01/2014,12/31/2015,addiction;Address;affective neuroscience;Area;Attention;Behavior;behavior influence;Behavioral;Brain;career;Clinical;Cognition;Cognitive;cognitive neuroscience;Cues;Disease;Event-Related Potentials;experience;Food;Foundations;Glass;Goals;improved;indexing;Individual;Individual Differences;innovation;Intervention;Investigation;Knowledge;Lead;Literature;long term memory;Maintenance;Measures;Memory;Mental Depression;Mental disorders;millisecond;Nature;novel;Patient Self-Report;Performance;Personality;pleasure;Process;psychopathic personality;Psychopathology;public health relevance;Recruitment Activity;Research;response;reward processing;Rewards;Schizophrenia;Sensory;sex;Short-Term Memory;skills;Specificity;Stimulus;stimulus processing;Techniques;Testing;Training;trait;visual search;Wine,Influence of Individual Differences in Reward Sensitivity on Cognitive Mechanisms,102888,ZRG1,Special Emphasis Panel,,,1,36079,
8527019,F32,AG,1,N,09/16/2013,01/01/2014,12/31/2014,866,F32AG044944,SCHOOLS OF PUBLIC HEALTH,PA-11-113,1F32AG044944-01,NIA:49214\,"Training, Individual",2013,NATIONAL INSTITUTE ON AGING,,BOSTON,UNITED STATES,GENETICS,07,149617367,US,HARVARD UNIVERSITY (SCH OF PUBLIC HLTH),MA,02115,"PUBLIC HEALTH RELEVANCE: Patient age is a critical risk factor common to a number of seemingly diverse pathologies, including cancer, neurodegenerative disease, cardiovascular disease, stroke, and type II diabetes. Dietary restriction and the genetic pathways that sense and regulate nutrient levels can improve healthy aging, however, and studies in animal models have shown that targeting these pathways provides broad therapeutic benefits against many age-onset diseases. The proposed studies will reveal novel therapeutic targets against age-related pathologies by elucidating the molecular-level mechanism linking nutrient-sensing to pro-longevity gene expression.            ",9211183;,"BURKEWITZ, KRISTOPHER;","FINKELSTEIN, DAVID B.",01/01/2014,01/31/2016,5'-AMP-activated protein kinase;Adverse effects;Age;Age of Onset;age related;Aging;Alleles;Animal Model;biological adaptation to stress;Caenorhabditis elegans;Cardiovascular Diseases;Cell Culture Techniques;cell type;Chronic;Communication;CREB1 gene;Cues;detection of nutrient;Diabetes Mellitus;dietary restriction;Disease;Eating;Engineering;Exclusion;Experimental Genetics;Family;Fertility;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;Health Benefit;healthy aging;Histocompatibility Testing;Homeostasis;Human;improved;Intervention;Intestines;Link;Liver;Longevity;longevity gene;Longevity Pathway;Maintenance;Malignant Neoplasms;Malnutrition;Mammalian Cell;Mammals;Mediating;Mediator of activation protein;Metabolic;Metabolism;Modeling;Molecular;Morphology;Muscle;mutant;Nature;Nematoda;Neurodegenerative Disorders;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nuclear;Nutrient;nutrition;Nutritional;Output;Pathology;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Physiological;Play;prevent;Process;programs;psychologic;public health relevance;Regulation;Research;research study;response;Risk Factors;RNA Interference;Role;Scientist;sensor;Signal Transduction;skills;Stress;stroke;System;Techniques;Testing;Therapeutic;Tissues;Training;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transgenic Animals;Transgenic Organisms,Targeting novel AMPK effectors in the regulation of healthy aging,44944,ZRG1,Special Emphasis Panel,,,1,49214,
8526962,F32,AG,1,N,09/16/2013,12/01/2013,11/30/2014,866,F32AG044946,,PA-11-113,1F32AG044946-01,NIA:53942\,"Training, Individual",2013,NATIONAL INSTITUTE ON AGING,,NOVATO,UNITED STATES,,02,786502351,US,BUCK INSTITUTE FOR RESEARCH ON AGING,CA,94945,"PUBLIC HEALTH RELEVANCE: This proposal explores the novel hypothesis that normal aging contributes to carcinogenesis in vivo due to an accumulation of senescent cells and their pro- inflammatory senescence-associated secretory phenotype (SASP), and that EGCG reduces the harmful effects of senescent cells. The proposed experiments will determine the stage at which cellular senescence fuels carcinogenesis and provide a rationale for developing natural chemotherapeutic compounds against the SASP.                ",8959048;,"ALIMIRAH, FATOUMA;","VELAZQUEZ, JOSE M.",12/01/2013,11/30/2016,Address;Adult;Affect;Age;age related;aged;Aging;Animals;Antineoplastic Agents;Apoptosis;Attenuated;Cancer Etiology;carcinogenesis;CDKN2A gene;Cell Aging;Cell Culture Techniques;Cell Cycle;cell growth;cell injury;cell killing;Cells;Characteristics;chemokine;chemotherapeutic agent;Coupled;cytokine;design;Development;Diet;Disease;DNA;Elderly;Embryo;Epigallocatechin Gallate;Evolution;Excision;Fibroblasts;Ganciclovir;Goals;Green tea (dietary);Growth Inhibitors;Herpesviridae;in vivo;Inflammatory;insight;Killings;Laboratories;Malignant Neoplasms;malignant phenotype;Modeling;Molecular;mouse model;Mus;normal aging;Normal Cell;novel;nucleoside analog;Oncogenic;Organism;Pathology;Pathway interactions;Peptide Hydrolases;Phenotype;polyphenol;prevent;Proliferating;Promotor (Genetics);Property;public health relevance;research study;response;Role;senescence;Signal Transduction;Skin Cancer;Skin Carcinogenesis;Staging;Testing;Therapeutic Agents;Tissues;TK Gene;Transgenic Mice;tumor;tumor progression;Tumor Suppressor Proteins;Wild Type Mouse;Xenograft procedure,Role of Cellular Senescence in Carcinogenesis,44946,ZRG1,Special Emphasis Panel,,,1,53942,
8648167,F32,AI,1,N,01/17/2014,02/01/2014,01/31/2015,855,F32AI106175,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,1F32AI106175-01A1,NIAID:53942\,"Training, Individual",2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PRINCETON,UNITED STATES,BIOCHEMISTRY,12,002484665,US,PRINCETON UNIVERSITY,NJ,085440036,"PUBLIC HEALTH RELEVANCE: Human cytomegalovirus (HCMV) latently infects a large portion of the global population. Using poorly understood mechanisms, the virus can hide in blood cells, from which it can later reactivate causing severe disease or death. Knowledge gained from the proposed study will identify mechanisms used by the virus to establish and maintain latency, and facilitate identification of new treatment options for HCMV related disease.           ",11123272;,"OBERSTEIN, ADAM LEE;","BEISEL, CHRISTOPHER E.",02/01/2014,01/31/2017,Blood Cells;career;CD14 gene;Cell Lineage;Cell membrane;Cell physiology;Cell surface;Cell Surface Proteins;cell type;Cells;Cessation of life;Clinical;Coupled;Cytomegalovirus;Cytomegalovirus Infections;Disease;Drug Targeting;experience;Flow Cytometry;Goals;Hematopoietic stem cells;Herpesviridae;Human;Immunocompromised Host;improved;Individual;Infection;insight;interest;Knowledge;latency-associated protein;latent infection;Learning;Life;Liquid Chromatography;Maintenance;Marketing;Mass Spectrum Analysis;Membrane Proteins;Mind;Modeling;Molecular Virology;monocyte;Myelogenous;new technology;Newborn Infant;novel;Patients;Pharmacologic Substance;Phenotype;Population;Protein Analysis;Proteins;Proteome;Protocols documentation;public health relevance;Research;Research Personnel;research study;Resolution;Satellite Viruses;Signal Pathway;Signal Transduction;Site;System;tandem mass spectrometry;Techniques;Technology;tissue culture;tissue/cell culture;Training;Virus;Virus Latency;Western Blotting;Work,Cell surface proteome of monocytes latently infected with human cytomegalovirus,106175,ZRG1,Special Emphasis Panel,,A1,1,53942,
8645153,F32,AI,1,N,01/16/2014,02/01/2014,01/31/2015,855,F32AI109834,SCHOOLS OF MEDICINE,PA-11-113,1F32AI109834-01,NIAID:49214\,"Training, Individual",2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DURHAM,UNITED STATES,GENETICS,04,044387793,US,DUKE UNIVERSITY,NC,27705,PUBLIC HEALTH RELEVANCE: Dengue virus is an arthropod-borne global health threat for which there is no vaccine or treatment. The goal of this application is to identify host cell RNA-binding proteins that are required for dengue virus replication in both human and mosquito cells. This work may lead to the identification of candidate targets for anti-viral compounds.            ,10439195;,"PHILLIPS, STACIA L;","CASSETTI, CRISTINA ",02/01/2014,01/31/2017,Aedes (genus);Arboviruses;Arthropods;Binding (Molecular Function);Biochemical Genetics;Biology;candidate identification;Categories;Cell physiology;Cells;clinically relevant;Complex;crosslink;Culicidae;Defect;Dengue;Dengue Virus;Disease;Endoplasmic Reticulum;Exposure to;Flavivirus;Gene Silencing;global health;Goals;Human;Human Cell Line;in vivo;Infection;innovation;Insecta;Integration Host Factors;Laboratories;Lead;Life;Mass Spectrum Analysis;Mediating;Membrane;Methodology;Methods;Molecular;Molecular Biology;Molecular Virology;Monitor;Mutagenesis;National Institute of Allergy and Infectious Disease;novel;pathogen;Pharmaceutical Preparations;Polypyrimidine Tract-Binding Protein;Prevalence;prevent;Process;Production;Proteins;public health relevance;Recruitment Activity;Reporter;Research;RNA;RNA chemical synthesis;RNA Interference;RNA-Binding Proteins;RNA-Protein Interaction;Role;Testing;Translations;transmission process;Vaccines;vector mosquito;Viral;Viral Genome;viral RNA;Virus;Virus Diseases;Virus Replication;Work,The role of host RNA-binding proteins in regulating dengue virus replication,109834,ZRG1,Special Emphasis Panel,,,1,49214,
8649909,F32,AI,1,N,01/16/2014,02/01/2014,01/31/2015,855,F32AI110028,SCHOOLS OF PUBLIC HEALTH,PA-11-113,1F32AI110028-01,NIAID:49214\,"Training, Individual",2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,001910777,US,JOHNS HOPKINS UNIVERSITY,MD,21218,"PUBLIC HEALTH RELEVANCE: M. tuberculosis RpsA is a newly reported target for Pyrazinamide (PZA), the only frontline drug that has preferential activity for the persister state f Mtb and shortens TB chemotherapy. Recently, several strains of PZA resistant TB have been shown to harbor mutations in the target of PZA, RpsA. This proposal aims to functionally, structurally, and biophysically characterize RpsA to further our understanding of the role that this interaction plays in PZA action, trans-translation, and drug resistance.            ",11695197;,"GUERRA LARA, ALFREDO JOSE;","JACOBS, GAIL G.",02/01/2014,01/31/2017,Actinobacteria class;Address;Affinity;Air;Alanine;Amino Acids;Antibiotics;Bacteria;Binding (Molecular Function);Binding Sites;Biochemical;Biological Assay;Biological Process;Biomolecular Nuclear Magnetic Resonance;burden of illness;C-terminal;Calorimetry;Cessation of life;chemotherapy;Clinical;clinically relevant;Code;combat;Communicable Diseases;Complex;Crystallography;Data;design;Disease;Drug resistance;Drug Resistant Tuberculosis;Gel;Genes;Genus Mycobacterium;Goals;Growth;improved;In Vitro;in vivo;Individual;insight;Lead;Ligand Binding;Ligands;Link;Maps;Measures;Mediating;Messenger RNA;Modeling;Molecular;Molecular Target;mutant;Mutation;Mycobacterium tuberculosis;NMR Spectroscopy;Organism;overexpression;pathogenic bacteria;Peptides;Pharmaceutical Preparations;Play;Point Mutation;polypeptide;Predisposition;Process;Property;Proteins;public health relevance;Pyrazinamide;Pyrazinamide resistance;pyrazinoic acid;Recycling;Regimen;Reporting;Resistance;resistance mechanism;resistance mutation;ribosomal protein S1;Ribosomal Proteins;Ribosomes;RNA Binding;RNA Recognition Motif;Role;Series;Signal Transduction;Stress;Surface Plasmon Resonance;Symptoms;Testing;Titrations;Transfer RNA;translation assay;Translations;Tuberculosis;tuberculosis drugs;Variant;Work,The POA-RpsA interaction in trans-translation inhibition in M. tuberculosis,110028,ZRG1,Special Emphasis Panel,,,1,49214,
8716319,F32,AI,1,N,01/15/2014,01/16/2014,01/15/2015,855,F32AI112248,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,1F32AI112248-01,NIAID:47114\,"Training, Individual",2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PASADENA,UNITED STATES,NONE,29,009584210,US,CALIFORNIA INSTITUTE OF TECHNOLOGY,CA,91125,"PUBLIC HEALTH RELEVANCE: Phenazine production is essential for the opportunistic human pathogen Pseudomonas aeruginosa to persist during infection. However, these molecules are double-edged swords in that they help the producers maintain cellular redox homeostasis but generate toxic reactive oxygen species as a byproduct of this activity. This proposal aims to understand how P. aeruginosa defends itself against the toxic effects of its own phenazine metabolites.                ",10609400;,"COSTA, KYLE CHRISTOPHER;","TAYLOR, CHRISTOPHER E.,",01/16/2014,01/15/2017,Address;advanced disease;Cystic Fibrosis;DNA;DNA Intercalation;Drug Metabolic Detoxication;Electrons;Environment;Enzymes;Excision;extracellular;Feedback;fitness;Generations;Growth;Hereditary Disease;Homeostasis;Human;in vivo;Infection;insight;intercalation;Lead;Lung;Measures;member;Metabolic;Metabolism;Microbial Biofilms;microbial community;Organism;Outcome;Oxidants;Oxidation-Reduction;oxidative damage;Oxygen;pathogen;Phenazines;Phenotype;Physiological;Physiology;Play;Population;Population Density;preference;prevent;Process;Production;Pseudomonas aeruginosa;public health relevance;Reactive Oxygen Species;research study;Resistance;response;Role;System;Testing;Tissues;Toxic effect;Up-Regulation (Physiology);Virulence Factors;Work,Defensive strategies against the toxic effects of self-produced phenazine metabol,112248,ZRG1,Special Emphasis Panel,,,1,47114,
8716154,F32,DC,1,N,01/24/2014,01/24/2014,01/23/2015,173,F32DC013934,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,1F32DC013934-01,NIDCD:50816\,"Training, Individual",2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,COLUMBIA,UNITED STATES,PSYCHOLOGY,06,041387846,US,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,SC,29208,"PUBLIC HEALTH RELEVANCE: Research focused on determining the clinical consequences of the FMR1 premutation is a significant public health priority, given new population-based screening indicating that 1 in 151 women carry this genetic defect (Seltzer et al., 2012). Although it is clear that the FMR1 premutation is associated with a range of debilitating physical and mental health conditions (e.g., premature ovarian insufficiency, fragile X tremor-ataxia syndrome, mood and anxiety disorders), the clinical manifestation of the FMR1 premutation is not yet well- understood. This proposal aims to clarify the nature, underlying mechanisms, and functional consequences of pragmatic (i.e., social language) impairments in the FMR1 premutation, which has implications for potential prevention and treatment efforts, and will inform the range of features that may be attributable to FMR1-related genetic effects.                ",10353573;,"KLUSEK, JESSICA;","SKLARE, DAN ",01/24/2014,01/23/2017,Adopted;Affect;Affective;Alleles;Anxiety;Anxiety Disorders;Area;autism spectrum disorder;Autistic Disorder;Back;Behavioral;Biochemical;Biological Markers;Child;Clinical;clinical phenotype;Collaborations;Communication;Communication impairment;comparison group;Development;Diagnosis;Disease susceptibility;disorder control;Environment;environmental stressor;experience;Family;FMR1 Gene;Fragile X Syndrome;Friendships;functional outcomes;Genes;Genetic;Genetic Predisposition to Disease;Grant;Health;High Prevalence;hypothalamic-pituitary-adrenal axis;Impairment;indexing;Individual;Language;Language Disorders;Lead;Light;Link;Literature;Mental Health;Mentorship;Methods;Mood Disorders;Mothers;Mutate;Mutation;Nature;Neurosciences;Neurosecretory Systems;Outcome;Ovarian;Phenotype;physical conditioning;Physiological;Population;population based;premature;Prevention;Process;public health medicine (field);public health priorities;public health relevance;Quality of life;Recording of previous events;Relative (related person);Research;Research Ethics;research study;Research Training;Risk;Scientific Advances and Accomplishments;screening;Severities;skills;social;Social Environment;Social support;South Carolina;Stress;Subgroup;Theoretical model;theories;Training;Tremor/Ataxia Syndrome;Universities;Woman;Work;Writing,Profiles and Predictors of Pragmatic Language Impairments in the FMR1 Premutation,13934,ZDC1,Special Emphasis Panel,,,1,50816,
8649764,F32,ES,1,N,02/06/2014,02/01/2014,01/31/2015,113,F32ES022913,SCHOOLS OF MEDICINE,PA-11-113,1F32ES022913-01A1,NIEHS:53390\,"Training, Individual",2014,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,OMAHA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,168559177,US,UNIVERSITY OF NEBRASKA MEDICAL CENTER,NE,681987835,"PUBLIC HEALTH RELEVANCE: The proposed studies are relevant to public health because they will demonstrate how dietary omega-3 fatty acid-derived lipid mediators like maresin-1 can be used in treating and preventing airway inflammation and disease caused by agricultural-related dust exposures. These experiments will lay the foundation for testing these lipid mediators for their utility in other environmental exposure-related airway diseases, including those caused by tobacco smoke, diesel exhaust, and other air pollutants. This project is relevant to the mission of NIEHS because the expected results will advance efforts in promoting healthier lives by potentially transforming how environmental exposure-related airway diseases are prevented and treated.            ",10119304;,"NORDGREN, TARA;","CHADWICK, LISA ",02/01/2014,01/31/2016,Acute;Agricultural Workers;Agriculture;Air Pollutants;airway epithelium;airway inflammation;Anti-inflammatory;Anti-Inflammatory Agents;Attenuated;career;Cause of Death;Cell Adhesion Molecules;Cellular Infiltration;Chronic;Chronic Obstructive Airway Disease;combat;cytokine;Data;Diesel Exhaust;Diet;Disease;Dose;Dust;Employee Strikes;Environmental Exposure;Epithelial Cells;Exposure to;Foundations;Goals;Health Benefit;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Intercellular adhesion molecule 1;Investigation;Knowledge;Lead;lipid mediator;Lung;Lung Inflammation;Lung Lavage Fluid;macrophage;Mediator of activation protein;Mission;Modeling;Mus;National Institute of Environmental Health Sciences;neutrophil;novel;Occupational Exposure;Omega-3 Fatty Acids;Pilot Projects;pre-clinical;prevent;Process;Property;public health medicine (field);public health relevance;Recruitment Activity;Research;research study;response;Role;Scheme;Serum Response Factor;Signal Transduction;Slice;Testing;Therapeutic;Tobacco smoke;Treatment Protocols;United States;Work,Effects of maresin-1 &organic dust on lung inflammation,22913,ZRG1,Special Emphasis Panel,,A1,1,53390,
8644337,F32,EY,1,N,12/05/2013,01/01/2014,12/31/2014,867,F32EY023456,SCHOOLS OF MEDICINE,PA-11-113,1F32EY023456-01A1,NEI:52190\,"Training, Individual",2014,NATIONAL EYE INSTITUTE,,PITTSBURGH,UNITED STATES,OPHTHALMOLOGY,14,004514360,US,UNIVERSITY OF PITTSBURGH,PA,15213,"PUBLIC HEALTH RELEVANCE: Selective attention gives us the ability to pick out the most important bits of information from the overwhelmingly rich visual world. Disruptions of this abilit have been implicated in a number of diseases and disorders such as attention deficit disorder, autism, and schizophrenia. The knowledge gained from this research about how attention functions in healthy individuals will help guide future investigations of disorders that involve attention, as well as potential therapeutic interventions for deficient attention control.                ",9699499;,"SNYDER, ADAM CHRISTOPHER;","AGARWAL, NEERAJ ",01/01/2014,12/31/2015,Animals;Area;Attention;Attention Deficit Disorder;Autistic Disorder;Award;base;Behavioral;Brain;brain computer interface;career;Cognitive;Complement;Contralateral;Cues;design;Detection;Disease;electrical potential;electrical property;Electrophysiology (science);Equilibrium;Eye;Foundations;Frequencies (time pattern);Future;gaze;Goals;Health;Human;Image;imaging modality;improved;Individual;innovation;interest;Investigation;Knowledge;Laboratories;Life;Link;Measures;Methodology;Methods;Modeling;Monitor;Neurons;nonhuman primate;operation;Outcome;parallel processing;Perception;Performance;Phase;Population;Postdoctoral Fellow;Primates;Process;Professional Practice;public health relevance;relating to nervous system;Research;Research Project Grants;research study;Research Subjects;Resources;Scalp structure;Schizophrenia;Scientist;selective attention;Signal Transduction;Source;Stimulus;stimulus processing;Structure;Surface;Synaptic Potentials;System;Task Performances;Techniques;Therapeutic Intervention;Time;Training;Unit of Measure;Variant;Visual;Visual attention;Visual Perception;Visual system structure,Micro- and macro-scale cortical dynamics underlying visual attention,23456,ZRG1,Special Emphasis Panel,,A1,1,52190,
8648442,F32,EY,1,N,12/20/2013,01/01/2014,12/31/2014,867,F32EY023526,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,1F32EY023526-01A1,NEI:52190\,"Training, Individual",2014,NATIONAL EYE INSTITUTE,,NASHVILLE,UNITED STATES,PSYCHOLOGY,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212,"PUBLIC HEALTH RELEVANCE: The goal of this training plan is to reveal brain activity underlying our ability to make decisions and control our actions, and to develop a model that explains these processes. It is important to understand how behavior relates to brain function, and the proposed research will improve diagnoses and treatment of multiple brain and neuropsychiatric disorders, and will help understand self-control across the lifespan.            ",9680314;,"MIDDLEBROOKS, PAUL G;","AGARWAL, NEERAJ ",01/01/2014,12/31/2016,Accounting;Address;Architecture;Area;base;Behavior;behavior test;Behavioral;Brain;career;Cognitive;cognitive function;cognitive neuroscience;Collection;Coupled;Data;Decision Making;Development;Diagnosis;Diagnostic;Diffusion;Disease;Drug Formulations;executive function;Exercise;experience;Foundations;frontal eye fields;Goals;Gold;Human;improved;Knowledge;Learning;Longevity;Macaca;Macaca mulatta;Maps;Mental disorders;Modeling;Monkeys;Movement;nervous system disorder;neuromechanism;Neurons;neurophysiology;neuropsychiatry;Neurosciences Research;oculomotor;Prefrontal Cortex;Process;public health relevance;Race;Reaction Time;relating to nervous system;Research;Research Personnel;Research Training;response;Saccades;sample fixation;Sampling;Self-control as a personality trait;Signal Transduction;skills;Stimulus;success;Task Performances;Testing;Time;Training;Visual;visual neuroscience;visual process;visual processing;Work,Neuronal mechanisms of response inhibition during decision making,23526,ZRG1,Special Emphasis Panel,,A1,1,52190,
8649962,F32,EY,1,N,12/09/2013,12/09/2013,12/08/2014,867,F32EY023921,EARTH SCIENCES/RESOURCES,PA-11-113,1F32EY023921-01A1,NEI:52190\,"Training, Individual",2014,NATIONAL EYE INSTITUTE,,COLLEGE PARK,UNITED STATES,BIOLOGY,05,790934285,US,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,MD,207425141,"PUBLIC HEALTH RELEVANCE: During natural vision the eyes are constantly in motion, producing large jumps several times a second that provide the dominant temporal structure to the visual input. The proposed study will examine how these eye movements shape cortical network activity, and how such network activity in turn influences the visual processing of individual cortical neurons. The results will improve our understanding of the role of eye movements in human visual processing, and also provide insights into general principles of how information processing of cortical neurons is structured by active perception.                ",11498874;,"MCFARLAND, JAMES MONROE;","AGARWAL, NEERAJ ",12/09/2013,12/08/2016,Accounting;Address;area striata;awake;Behavioral;brain machine interface;Characteristics;Code;cognitive function;Complex;Cortical Synchronization;design;Development;Electrodes;Environment;Eye;Eye Movements;Frequencies (time pattern);gaze;Goals;Human;improved;Individual;information processing;insight;interest;Link;Location;Macaca;Measures;Modeling;Motion;neural prosthesis;Neurons;novel;Pattern;Perception;Phase;Play;Primates;Process;public health relevance;relating to nervous system;Research;research study;response;Response to stimulus physiology;Retinal;Role;Saccades;Sampling;Sensory;Sensory Process;Shapes;Signal Transduction;Simulate;spatiotemporal;statistics;Stereotyping;Stimulus;stimulus processing;Structure;Testing;Time;V1 neuron;Vision;Visual;visual control;Visual Cortex;Visual Perception;visual process;visual processing;visual stimulus;Work,The influence of eye movements on visual cortical processing through the entrainm,23921,ZRG1,Special Emphasis Panel,,A1,1,52190,
8647111,F32,HD,1,N,12/20/2013,01/01/2014,12/31/2014,865,F32HD079169,ORGANIZED RESEARCH UNITS,PA-11-113,1F32HD079169-01,NICHD:49214\,"Training, Individual",2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,CAMBRIDGE,UNITED STATES,NONE,07,001425594,US,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,MA,02139,"PUBLIC HEALTH RELEVANCE: This proposal will test whether the anatomical connections between brain regions determine the location and selectivity of specialized functions in adults and children, and the results will have valuable insights into the developmental origins of healthy adult brain function. These results will also have practical relevance for clinical research, by providing a method to infer functional brain maps from structural images alone in individuals who cannot be functionally scanned, for example in pre-surgical mapping of low-functioning or comatose subjects, or in sleeping infants (enabling earlier diagnosis and intervention in neurodevelopmental disorders such as autism, ADHD, and dyslexia).            ",11709631;,"SAYGIN, ZEYNEP;","FREUND, LISA S",01/01/2014,12/31/2016,5 year old;Accounting;Address;Adult;Age;age related;Area;area striata;Attention deficit hyperactivity disorder;Autistic Disorder;Behavioral;Brain;Brain Mapping;Brain region;Categories;Cereals;Characteristics;Child;Childhood;Clinical Research;Cognition;Cognitive;Coma;Coupled;Data Set;Development;Diffusion weighted imaging;Disease;Dyslexia;Early Diagnosis;Early Intervention;Etiology;Face;Fingerprint;follow-up;Functional Magnetic Resonance Imaging;Fusiform gyrus;Health;Heterogeneity;Human;Image;Individual;Individual Differences;Individuality;Infant;insight;Language;Lateral Geniculate Body;Learning;Linguistics;Location;Maps;Measures;Methodology;Methods;Mind;Motor;motor control;neurodevelopment;Neurodevelopmental Disorder;Neurosciences;novel;Operative Surgical Procedures;Optics;Orthography;Pattern;Persons;Plant Roots;Play;Population;Process;public health relevance;Radiation;Reading;relating to nervous system;Research;research study;response;Rest;Retina;Role;Scanning;segregation;Sensory;Shapes;Sleep;social cognition;Structure;Testing;theories;Time;Visual;visual information;Visual Perception;Work,How connectivity determines function in the mature and developing human brain,79169,ZRG1,Special Emphasis Panel,,,1,49214,
8457448,F32,HL,1,N,08/05/2013,01/01/2014,12/31/2014,837,F32HL117598,SCHOOLS OF MEDICINE,PA-11-113,1F32HL117598-01,NHLBI:66530\,"Training, Individual",2013,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"PUBLIC HEALTH RELEVANCE: As the third leading cause of death in the United States, chronic obstructive pulmonary disease (COPD) is a common disease and an important public health concern. While much progress has been made in understanding the cellular and molecular basis of asthma, leading to new treatment strategies, significantly less progress has been made in COPD. The goal of this work is to 1) identify patients with COPD that express transcriptomic signatures that we have previously found to be relevant in asthma and 2) detect additional clinically relevant COPD-specific transcriptomic signatures in the hope of distinguishing specific groups of individuals that may respond to established and new treatment strategies.            ",11212017;,"CHRISTENSON, STEPHANIE A;","TIGNO, XENIA ",01/01/2014,12/31/2014,Adrenal Cortex Hormones;airway hyperresponsiveness;Airway Obstruction;Amphiregulin;Area;Asthma;atopy;base;Biological Response Modifiers;bronchial epithelium;Bronchoscopy;Cause of Death;Cells;Chronic Obstructive Airway Disease;cigarette smoke;Clinical;clinical phenotype;clinically relevant;Cluster Analysis;cohort;Conditioned Culture Media;Data;Data Set;Development;Disease;Epidermal Growth Factor Receptor;Epithelial;Epithelial Cells;Exhibits;Family;Family member;Gene Expression;Genes;Genomics;Goals;Health;Heterogeneity;Human;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory Response;injured airway;insight;Interleukin-13;Lead;Ligands;Linear Models;Mediating;Mediator of activation protein;member;Messenger RNA;Metaplasia;MicroRNAs;Molecular;Molecular Profiling;Mucous body substance;notch protein;novel;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Play;Prevalence;Process;Production;public health medicine (field);public health relevance;Publishing;Regulation;Repression;Research;response;Role;Sampling;Smoke;Smoker;Smoking;Stimulus;Testing;Therapeutic;TNF gene;Tobacco smoke;tool;transcriptomics;treatment strategy;United States;Up-Regulation (Physiology);Work,Common genomic mechanisms of disease across asthma and COPD,117598,ZRG1,Special Emphasis Panel,,,1,66530,
8594323,F32,HL,1,N,08/20/2013,09/01/2013,08/31/2014,837,F32HL120396,SCHOOLS OF MEDICINE,PA-11-113,1F32HL120396-01,NHLBI:71670\,"Training, Individual",2013,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,001910777,US,JOHNS HOPKINS UNIVERSITY,MD,21218,"PUBLIC HEALTH RELEVANCE: Asthma is an increasingly common, often debilitating, and enormously costly disease, whose rising prevalence has been temporally linked to a shift in dietary patterns towards a Western diet. This proposal seeks to investigate whether a Western dietary pattern (typified by higher intakes of processes foods such as meats and refined grains, n6-polyunsaturated fatty acids, high fat dairy products, and sugary desserts and drinks) is associated with increased asthma prevalence and morbidity. If an association exists, future steps would include educational programs and dietary interventions to intervene on this modifiable risk factor for the sake of improving asthma health.            ",11496430;,"BRIGHAM, EMILY;","TIGNO, XENIA ",09/01/2013,08/31/2015,Accounting;Acute;Address;Adherence (attribute);Adult;Affect;African American;Allergic Disease;Antioxidants;Asthma;Atherosclerosis;Baltimore;base;Cardiovascular system;Centers for Disease Control and Prevention (U.S.);Cereals;Characteristics;Cities;Clinical;clinically significant;cohort;Cohort Studies;Communities;Complex;Dairy Products;Data;Data Analyses;Data Collection;Development;Diagnosis;Diet;Diet good;Dietary Assessment;Dietary Component;Dietary Fiber;Dietary intake;Dietary Intervention;Dietary Practices;Disease;disorder risk;drinking;Dual-Energy X-Ray Absorptiometry;Eating;Elements;Enrollment;Environmental Exposure;Epidemic;Epidemiologic Studies;Epidemiology;Evaluation;experience;fast food;Fatty acid glycerol esters;Fatty Acids;Female;Fishes;Food;Food Processing;Foundations;Frequencies (time pattern);fruits and vegetables;Funding;Future;Health;Healthcare;high risk;Hospitalization;Hour;Human Characteristics;Immersion Investigative Technique;improved;Individual;Indoor Air Pollution;inner city;Intake;interest;Investigation;Link;Longitudinal Studies;Low income;Lung diseases;Macronutrients Nutrition;Manuscripts;Measurement;Measures;Meat;Mediterranean Diet;Mentored Patient-Oriented Research Career Development Award;Minerals;Minority;modifiable risk;Morbidity - disease rate;Mortality Vital Statistics;National Research Service Awards;novel;Nutrient;Obesity;Observational Study;Olive oil preparation;Outcome;Parents;Participant;Pattern;Pharmaceutical Preparations;Play;Polyunsaturated Fatty Acids;Population;Preparation;Prevalence;programs;prospective;Protocols documentation;public health relevance;Questionnaires;Recruitment Activity;Research;Research Personnel;respiratory;Respiratory physiology;Risk;Risk Factors;Role;Sampling;Solid;sugar;Symptoms;Time;Training;trend;United States;Vitamins;Waist-Hip Ratio,Western Diet as an Independent Predictor of Asthma Prevalence and Morbidity,120396,ZRG1,Special Emphasis Panel,,,1,71670,
8646351,F32,HL,1,N,12/20/2013,01/01/2014,12/31/2014,837,F32HL121939,,PA-11-113,1F32HL121939-01,NHLBI:52190\,"Training, Individual",2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,,07,048682157,US,SEATTLE CHILDREN'S HOSPITAL,WA,98105,"PUBLIC HEALTH RELEVANCE: The research plan proposes to examine neuron-glia interactions for novel signaling pathways that underlie sigh generation and its periodicity, and to investigate neuron-glia dynamics under different physiological conditions such as hypoxia using both in vitro and in vivo approaches. The obtained data will be used to produce a more realistic model of respiratory network.            ",11755425;,"DASHEVSKIY, TATIANA;","TIGNO, XENIA ",01/01/2014,12/31/2016,Affect;Arousal;Atelectasis;ATP Receptors;base;Blood gas;Brain;Brain Stem;Breathing;Calcium Channel;Calcium Oscillations;Cell membrane;Cells;Chemicals;Chloride Channels;Complex;Computer Simulation;Data;Databases;Dependency (Psychology);Dyes;Electrodes;extracellular;feeding;Frequencies (time pattern);Generations;Glial Fibrillary Acidic Protein;Glutamates;Hypoxia;Image;improved;In Vitro;in vivo;Label;Lasers;Lead;Lesion;Light;Lung;Measures;Metabolic;Modeling;Mus;network models;Neuroglia;Neuromodulator;Neurons;novel;P(3)-1-(2-nitro)phenylethyladenosine 5'-triphosphate;P2X-receptor;Pattern;Periodicity;Physiological;Play;Population;Preparation;Proteins;public health relevance;purinoceptor P2Y1;receptor;Research;research study;respiratory;Respiratory System;response;Risk;Role;Signal Pathway;Simulate;Slice;Source;Sudden infant death syndrome;Synapses;System;Testing;Theoretical model;theories;Transgenic Mice;two-photon;voltage;voltage clamp,Involvement of glia in sighs generation,121939,ZRG1,Special Emphasis Panel,,,1,52190,
8736274,H79,TI,1,N,09/27/2013,09/30/2013,09/29/2014,,H79TI025426,,RFA-TI-13-006,1H79TI025426-01,,Unknown,2013,Center for Substance Abuse Treatment,,FRANKFORT,UNITED STATES,,06,,US,KENTUCKY STATE ADMINISTRATIVE OFF COURTS,KY,406019230,,11981933;,"SANDERS, DANIELLE;","SAMAYOA, GEORGE ",09/30/2013,09/29/2016,,Fayette County Adult Drug Court,25426,ZOA1,Special Emphasis Panel,,,1,,
8542365,I01,VA,1,N,02/06/2014,10/01/2013,09/30/2014,999,I01BX002190,,RFA-BX-12-001,1I01BX002190-01,,Research Projects,2014,Veterans Affairs,,HOUSTON,UNITED STATES,,09,078446044,US,MICHAEL E DEBAKEY VA MEDICAL CENTER,TX,770304211,"PUBLIC HEALTH RELEVANCE:         PROJECT NARRATIVE This project is focused on developing gene transfer technology for cystinuria, an inherited kidney disease in veterans. The proposed strategy could also be used for therapy for a variety of other human kidney diseases which plague veterans. Our proposed strategy is thefore extremely significant and relevant to the health of veterans and the overall mission of research within the VA.            ",1870787;,"WILSON, MATTHEW H;",,10/01/2013,09/30/2017,Adverse effects;Affect;Amino Acid Transporter;Animal Model;Animals;Area;base;Basic Amino Acids;Calculi;cell type;Cells;Cystine;Cystinuria;Data;Diamino Amino Acids;Disease;DNA delivery;DNA Transposons;Elements;Engineering;Epithelial Cells;Event;Experimental Designs;Future;Gene Delivery;Gene Expression;Gene Mutation;Gene Transfer;Genes;Genetic;Genomics;genotoxicity;Goals;Health;Human;Image;Immunohistochemistry;improved;in vivo;Inherited;Injection of therapeutic agent;innovation;Kidney;Kidney Calculi;kidney cell;Kidney Diseases;Mediating;Medical;Methodology;Methods;Mission;Modeling;Molecular Target;Monitor;Morbidity - disease rate;Mus;Mutation;Nephrons;novel;Plague;plasmid DNA;prevent;Proteins;public health relevance;Research;Research Design;Research Proposals;Site;Somatic Cell;Syndrome;System;Technology;therapeutic gene;Time;Tissues;tool;Toxic effect;Transgenes;Transposase;Tubular formation;urinary;vector;Veterans;Viral;Viral Vector;Work;Zinc Fingers,Kidney specific site-directed integration for cystinuria,2190,NEPH,Nephrology,,,1,,
8634229,K99,CA,1,N,02/04/2014,02/04/2014,01/31/2015,398,K99CA175179,,PA-11-197,1K99CA175179-01A1,NCI:147658\,Other Research Related,2014,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,,12,064931884,US,SLOAN-KETTERING INST CAN RES,NY,10065,"PUBLIC HEALTH RELEVANCE: Follicular lymphoma (FL) is a significant clinical problem. FLs are very common Non- Hodgkin's lymphomas that do not respond well to chemotherapy. In order to find new possible therapies, we looked at the most frequent chromosomal alterations in Follicular lymphoma patient samples. We observed genomic lesions affecting several oncogenic pathways (e.g. cell cycle regulation, B-cell receptor signaling, immune- response and Nf-kB pathway). In particular, cell cycle regulators are altered in ~ 50% of FL. These lesions are associated with advanced grade and shorter survival;however the underlying biology and implications for therapy have not been studied in this cancer. I will examine how loss of cell cycle control contributes to disease progression and how it affects treatment outcomes. I will also conduct pre-clinical studies of CDK inhibitors and new combination therapies in lymphoma. This study will offer the possibility of new therapies for a large number of FL patients. K99/R00 Career Developmental Grant        The written critiques of individual reviewers are provided in essentially unedited form in this section. Please note that these critiques and criteria scores were prepared prior to the meeting and may not have been revised subsequent to any discussions at the review meeting. The Resume and Summary of Discussion section above summarizes the final opinions of the committee.                ",11372368;,"ORICCHIO, ELISA;","SCHMIDT, MICHAEL K",02/04/2014,01/31/2016,"Advisory Committees;Affect;American;Animal Model;anticancer research;base;BCL2 gene;Biological;Biological Testing;Biology;Bone Marrow Transplantation;Calculi;Cancer Biology;cancer genetics;career;CDK4 gene;CDKN2A gene;Cell Cycle;Cell Cycle Regulation;Cell Line;chemotherapy;Chromosome abnormality;Clinical;Collection;Combined Modality Therapy;Controlled Study;Critiques;Cyclin-Dependent Kinase Inhibitor 2A;Data;Development;Disease Progression;DNA Damage;Doctor of Philosophy;Environment;Event;Figs - dietary;Follicular Lymphoma;functional genomics;Gene Mutation;gene therapy;Genes;Genetic;Genetic Programming;Genomics;Goals;Grant;Hand;Health;Immune;Immune response;improved;in vivo;in vivo Model;Individual;Indolent;inhibitor/antagonist;innovation;Italy;Laboratories;Lesion;leukemia/lymphoma;Lymphoma;Lymphomagenesis;Malignant Neoplasms;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;Methylation;Mobile Genetic Elements;Modeling;Molecular;mouse model;Mus;Mutation;neglect;Non-Hodgkin's Lymphoma;novel;novel therapeutics;Oncogenic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Positioning Attribute;Postdoctoral Fellow;preclinical study;Receptor Signaling;Receptors, Antigen, B-Cell;Reporting;Research;Research Proposals;Sampling;Scientist;Source;Specimen;success;Testing;Therapeutic;Therapeutic Studies;Transgenic Mice;Translations;Treatment outcome;Tumor Suppressor Proteins;Work;Writing",Dissecting the Genetics Of Follicular Lymphoma To Find New Therapies,175179,NCI,Subcommittee B - Comprehensiveness,,A1,1,147658,
8678358,K99,DC,1,N,02/01/2014,02/01/2014,01/31/2015,173,K99DC013805,,PA-11-197,1K99DC013805-01,NIDCD:103950\,Other Research Related,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,LA JOLLA,UNITED STATES,,49,781613492,US,SCRIPPS RESEARCH INSTITUTE,CA,920371000,"PUBLIC HEALTH RELEVANCE: Communication is a critical component to every aspect of our life and 1 in 5 American adults suffer from hearing loss, in addition, occupational noise induced hearing loss results in billions of dollars in economic costs (66,67,NIDCD). For what we believe to be the first time, we propose to apply quantitative mass spectrometry-based proteomics to the investigation of noise- induced hearing loss. These studies will yield a protein expression atlas of the mammalian inner ear auditory system at an unprecedented level and reveal novel pathways relevant to the successful prevention and treatment of noise-induced hearing loss.                ",10308463;,"SAVAS, JEFFREY NICHOLAS;","SKLARE, DAN ",02/01/2014,01/31/2016,Acoustic Stimulation;Adult;American;Animals;Antibodies;Apoptosis;Atlases;Auditory system;base;Biochemical;Bioinformatics;Biology;Categories;Cell Death;Cells;Characteristics;Cochlear Nerve;Cochlear structure;Communication;comparative;Data;Data Set;Databases;Defect;Development;disability;economic cost;Economics;Ensure;Environmental Health;Epilepsy;Etiology;Event;Exposure to;falls;FDA approved;Fractionation;Genetic Transcription;Glycerol;Goals;Hair;Hair Cells;Hearing;hearing impairment;Heredity;Huntington Disease;Immunohistochemistry;in vivo;Individual;Injury;Investigation;Knockout Mice;Label;Labyrinth;Life;Mass Spectrum Analysis;Measurement;Measures;Mentors;Methods;Mitogen-Activated Protein Kinases;Modeling;Molecular;Molecular Sieve Chromatography;Multiple Sclerosis;Mus;mutant;N-terminal;National Institute on Deafness and Other Communication Disorders;Necrosis;NMDA receptor antagonist;Noise;Noise-Induced Hearing Loss;novel;Occupational Health;Occupational Noise;Organ of Corti structure;Parkinson Disease;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Pilot Projects;prevent;Prevention;Protein Analysis;protein complex;protein expression;protein protein interaction;Proteins;Proteome;Proteomics;public health relevance;Quality of life;Reactive Oxygen Species;Reporter;Reporting;Research;research study;Risk;Role;Sedimentation process;Sensory;Shotguns;Spinal cord injury;stroke;Structure;Supporting Cell;Surveys;Synapses;System;Testing;Therapeutic;Time;Tissues;tool;Western Blotting;Work,Proteome Biology of Noise Induced Hearing Loss,13805,CDRC,Communication Disorders Review Committee,,,1,103950,
8576602,R01,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R01AA021390,SCHOOLS OF MEDICINE,PA-11-178,1R01AA021390-01A1,NIAAA:356625\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CLEVELAND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,11,077758407,US,CASE WESTERN RESERVE UNIVERSITY,OH,441067015,"Given the deleterious effects that alcohol abuse and alcoholism exert on individuals and our society, it is important to gain a better understanding of factors mediating physiological responses to alcohol. Studies in this proposal aim to address the regulation of alcohol metabolism by a genetic factor Kruppel- like factor 15. The results may provide the foundation for novel chronotherapeutic approaches to ameliorate the detrimental effects of chronic alcohol use.",8481872;,"LIN, ZHIYONG;","RADAEVA, SVETLANA ",02/05/2014,01/31/2019,"Acetaldehyde;Acute;Address;Affect;Alcohol abuse;alcohol effect;alcohol exposure;alcohol response;Alcoholic Liver Diseases;Alcoholism;Alcohols;aldehyde dehydrogenases;Ammonia;Animals;base;Behavior;Behavioral;Biological Process;Biology;cell injury;cellular development;Chip seq;Chronic;chronic alcohol ingestion;Chronotherapy;Circadian Rhythms;combat;Coupled;Disease;Enzymes;Ethanol Metabolism;Exhibits;Family;feeding;Foundations;Gene Targeting;Genes;Genetic;Goals;Health;Hepatic;Hour;Human;in vivo;Individual;insight;Knockout Mice;Life;Liver;liver function;liver injury;loss of function;MAPK8 gene;Mediating;Mediator of activation protein;member;Metabolism;Mitochondria;Molecular;Mus;novel;Organism;Pathway interactions;Patients;Pattern;Periodicity;Phenotype;Physiological;Physiological Processes;Plasma;Process;reconstitution;Regulation;Research;research study;Role;Societies;Time;Tissues;Toxic effect;transcription factor;Transcription Factor AP-1;transcriptome sequencing;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophanase;Urea;Weight;Weight Gain;Wild Type Mouse;Zinc Fingers",KLF15 and circadian regulation of alcohol-induced liver injury,21390,HBPP,Hepatobiliary Pathophysiology Study Section,,A1,1,356625,
8563078,R01,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R01AA022455,SCHOOLS OF MEDICINE,PA-11-260,1R01AA022455-01,NIAAA:326188\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BALTIMORE,UNITED STATES,PEDIATRICS,07,188435911,US,UNIVERSITY OF MARYLAND BALTIMORE,MD,212011508,"PUBLIC HEALTH RELEVANCE: Fetal alcohol spectrum disorder (FASD) is a leading cause of mental retardation. Here we test the hypothesis that early alcohol exposure has layer specific effects on the potentiation and depression components of neuronal plasticity in the visual cortex in vivo and in vitro. We will also test whether caffeine can restore neuronal plasticity in our model. Testing caffeine would be of particular relevance because this drug is routinely used as a therapeutic intervention in premature babies, which could facilitate its translation to FASD subjects.            ",8442859;,"MEDINA, ALEXANDRE ESTEVES;","CUI, CHANGHAI ",02/05/2014,01/31/2019,Address;Affect;alcohol exposure;Alcohols;AMPA Receptors;Anesthesia procedures;Animals;area striata;awake;base;Caffeine;Chemosensitization;Cognitive deficits;cognitive function;critical period;Defect;deprivation;Development;developmental disease/disorder;Dose;Electrophysiology (science);Endocannabinoids;Enhancers;Excitatory Synapse;experience;extracellular;Eye;Eyelid structure;Ferrets;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fragile X Syndrome;Functional disorder;Glutamates;Impairment;improved;In Vitro;in vivo;Individual;inhibitor/antagonist;Lead;Link;Mediating;Mental Depression;Mental Retardation;Modeling;Molecular;monocular deprivation;mouse model;Mus;neonatal hypoxic-ischemic brain injury;neurobehavioral;Neurologic;Neuronal Plasticity;Neurons;neurotransmission;novel therapeutics;Ocular Dominance;optic imaging;Pharmaceutical Preparations;phosphoric diester hydrolase;Premature Infant;Preparation;Process;public health relevance;repaired;Reporting;response;Signal Transduction;Slice;Surgical sutures;Synapses;Synaptic plasticity;Syndrome;Techniques;Testing;Therapeutic Intervention;transcription factor;Translations;transmission process;vinpocetine;Visual Cortex;Visual evoked cortical potential,Improving Neuronal Plasticity in a Mouse Model of FASD,22455,ZRG1,Special Emphasis Panel,,,1,326188,
8785958,R01,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R01AA023417,SCHOOLS OF MEDICINE,,1R01AA023417-01,NIAAA:364567\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,068610245,US,RUSH UNIVERSITY MEDICAL CENTER,IL,60612,,1966640 (contact);6107726;,"KESHAVARZIAN, ALI  (contact);KHAZAIE, KHASHAYARSHA;","JUNG, KATHY ",02/05/2014,01/31/2019,Address;alcohol consequences;Alcohol consumption;Alcohols;Attention;Automobile Driving;base;Benign;Biological;Bone Marrow;Bone Marrow Cells;cancer prevention;cancer risk;carcinogenesis;Carcinogens;CD4 Positive T Lymphocytes;Cell Communication;Cell physiology;cell type;Cells;Chimerism;Chronic;circadian pacemaker;Circadian Rhythms;Colon;Colon Carcinoma;Colorectal Cancer;Dendritic Cells;Development;Distal;Dominant-Negative Mutation;Eating;Environment;Environmental Risk Factor;Epidemiologic Studies;Ethanol;feeding;Food;food restriction;Functional disorder;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;Goals;Health;Health Hazards;Homeostasis;Hour;Human;ileum;Immune;Immunologics;immunopathology;Individual;Inflammation;Inflammatory Bowel Diseases;Instruction;Intervention;Intestines;Knowledge;Large Intestine;Lead;Life;Life Style;Light;Link;Malignant Neoplasms;mast cell;Mediating;Mitotic;Modeling;Molecular;mouse model;Mucosal Immunity;Mucositis;Mus;mutant;novel;Outcome;Pathologic;Pattern;Peripheral;Physiological;Play;polyposis;Polyps;Predisposing Factor;Predisposition;Prevention;Principal Investigator;problem drinker;Process;Regulation;Regulatory T-Lymphocyte;research study;Risk;Role;Schedule;Sentinel;Series;shift work;Sleep Wake Cycle;Small Intestines;Societies;Testing;treatment strategy;Work,Role of Alcohol and Circadian Disruption in Inflammation and Colon Cancer,23417,ZAA1,Special Emphasis Panel,,,1,364567,
8730947,R01,AI,1,N,02/04/2014,02/05/2014,01/31/2015,855,R01AI112381,SCHOOLS OF MEDICINE,PA-11-260,1R01AI112381-01,NIAID:319137\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLUMBIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,09,153890272,US,UNIVERSITY OF MISSOURI-COLUMBIA,MO,65211,"PUBLIC HEALTH RELEVANCE: Viruses must enter host cells to initiate infection, and hosts have evolved various strategies to limit viral infections. We study how some cellular factors intrinsically block the viral entry and infections, including those of pathogenic HIV-1. The proposed studies may lead to novel strategies against viral diseases.            ",10637051;,"LIU, SHAN-LU;","SHARMA, OPENDRA K.",02/05/2014,01/31/2019,Acquired Immunodeficiency Syndrome;Address;Antiviral Agents;Binding Sites;Biochemical;Biological Assay;Cell fusion;Cell membrane;Cells;Collaborations;CXCR4 gene;Dengue Virus;Development;Ebola virus;Endosomes;env Gene Products;Exhibits;Genome;Goals;HIV;HIV Infections;HIV-1;Human;IFITM1 gene;Image;Immunity;in vivo;Infection;Influenza A virus;insight;Integral Membrane Protein;Interferons;Knowledge;Lead;Lipids;Mediating;Membrane;Membrane Fusion;Molecular Conformation;Morbidity - disease rate;Mortality Vital Statistics;Murine leukemia virus;Mus;Mutation;nonhuman primate;novel;novel strategies;Orthologous Gene;particle;Pathogenesis;Patients;Play;Primate Lentiviruses;Process;Production;public health relevance;Refractory;Reporting;research study;Resistance;Rice;RNA Interference;Role;SARS coronavirus;Series;Techniques;Testing;Tyrosine Phosphorylation;Ubiquitination;Universities;Viral;Virus;Virus Diseases;West Nile virus;Work,IFITM-mediated Inhibition of HIV Infection and Viral Countermeasures,112381,AMCB,AIDS Molecular and Cellular Biology Study Section,,,1,319137,
8639302,R01,CA,1,N,02/05/2014,02/05/2014,01/31/2015,396,R01CA175747,SCHOOLS OF MEDICINE,PA-11-260,1R01CA175747-01A1,NCI:370739\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,UNIV OF NORTH CAROLINA CHAPEL HILL,NC,27599,"PUBLIC HEALTH RELEVANCE: Effective signal targeted therapies for pancreatic cancer, the 4th cause of cancer deaths in the US, remain to found. Our studies support a critical role for a lesser studied effector pathway of the K-Ras oncoprotein, mutated in essentially all pancreatic cancers, the Rac1-PAK1 signaling network. Our application of state-of-the art tools will elucidate the complex and dynamic nature of PAK1 signaling to facilitate the clinical development of anti-PAK1 therapies for defining the long elusive anti-Ras therapy for this deadly cancer.            ",1860326 (contact);1865701;,"DER, CHANNING J (contact);HAHN, KLAUS MICHAEL;","YASSIN, RIHAB R,",02/05/2014,01/31/2019,1-Phosphatidylinositol 3-Kinase;Address;Apoptotic;Automobile Driving;Binding (Molecular Function);Biological;BRAF gene;Bypass;cancer cell;Cancer Etiology;cancer therapy;Cell Culture Techniques;Cell Death;Cell membrane;Cessation of life;Clinical;clinical efficacy;Collection;Complex;Computer Simulation;Conflict (Psychology);Dependency (Psychology);design;Development;Digit structure;drug discovery;Drug resistance;Drug Targeting;Employee Strikes;Event;exome sequencing;Failure (biologic function);Feedback;Growth;human FRAP1 protein;inhibitor/antagonist;innovation;interest;KRAS2 gene;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP2K1 gene;mathematical model;MEKs;melanoma;Mitochondria;Mitogen-Activated Protein Kinases;Monomeric GTP-Binding Proteins;mouse model;mutant;Mutate;Nature;Nuclear;Oncogene Proteins;Output;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Phosphatidylethanolamine Binding Protein;Phosphorylation;Phosphotransferases;pre-clinical;Protein Kinase;protein kinase inhibitor;Protein Kinase Inhibitors;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-akt;public health relevance;Regulation;research clinical testing;Research Personnel;Resistance;resistance mechanism;Role;Route;sensor;Signal Transduction;Signaling Protein;Skin Neoplasms;small molecule;Staging;Therapeutic;therapeutic target;tool;tumor;Tumor Biology;Validation,"Mechanisms of PAK1 activation, signaling and tumor resistance",175747,TCB,Tumor Cell Biology Study Section,,A1,1,370739,
8731458,R01,CA,1,N,02/07/2014,02/07/2014,01/31/2015,393,R01CA180758,SCHOOLS OF MEDICINE,PA-10-290,1R01CA180758-01A1,NCI:320588\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,NORTH CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,10,069501252,US,ROSALIND FRANKLIN UNIV OF MEDICINE &SCI,IL,60064,PUBLIC HEALTH RELEVANCE:  Kaposi's sarcoma associated herpesvirus (KSHV) is etiologically associated with Kaposi's sarcoma and primary effusion lymphoma. The proposed studies will investigate innate sensing of the KSHV genome in the infected cell nucleus. These studies are significant since such comprehensive understanding of nuclear innate responses will provide novel targets to block latent KSHV infection and the associated diseases.                ,7673486;,"CHANDRAN, BALA;","READ-CONNOLE, ELIZABETH LEE",02/07/2014,01/31/2019,"Acetylation;Apoptosis;Area;B-Cell Lymphomas;B-Lymphocytes;Biological Assay;Bromodeoxyuridine;Caspase-1;Cell Line;Cell Nucleus;Cells;Chip on Chip;Chronic;Complex;cytokine;Cytoplasm;Defense Mechanisms;Dermal;design;Disease;DNA;DNA Binding;DNA Damage;DNA Viruses;effusion;Elements;Endothelial Cells;Epstein-Barr Virus latency;fast protein liquid chromatography;Genome;Goals;Herpesviridae Infections;Herpesvirus 1, Human;Histone H2B;HIV-1;Human;Human Herpesvirus 4;human herpesvirus 8;Immune response;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;Interferon Type II;Interferons;Interleukin-1;Interleukin-18;Kaposi Sarcoma;Knowledge;Label;Lead;Lesion;Ligation;Link;Lytic;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Microscopy;Modification;Molecular;new technology;next generation sequencing;novel;Nuclear;Oral;pathogen;Pathogenesis;Pathway interactions;Patients;Phase;primary effusion lymphoma;procaspase-1;Process;Promotor (Genetics);Proteins;Proteolytic Processing;public health relevance;Regulator Genes;Research;response;Reverse Transcriptase Polymerase Chain Reaction;Role;sensor;Site;Testing;Therapeutic;Time;transcriptome sequencing;Viral Proteins",KSHV interactions with host inflammasome components,180758,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,A1,1,320588,
8615683,R01,CA,1,N,02/04/2014,02/04/2014,01/31/2015,396,R01CA182467,SCHOOLS OF MEDICINE,PA-11-260,1R01CA182467-01,NCI:320588\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,NORTHWESTERN UNIVERSITY AT CHICAGO,IL,60611,PUBLIC HEALTH RELEVANCE:  Breast cancer metastasis remains as a major obstacle for the treatment of breast cancer. The primary goal of this proposal is to investigate the mechanisms by which CD44 promotes breast cancer metastasis. A better understanding and identification of new regulatory mechanisms in cancer pathogenesis will facilitate the development of new strategies for the treatment of metastatic breast cancer.            ,7893348;,"CHENG, CHONGHUI;","WOODHOUSE, ELIZABETH ",02/04/2014,01/31/2019,Alternative Splicing;Animals;Binding (Molecular Function);Breast Cancer Cell;Breast Cancer Treatment;Cancer Etiology;CD44 Antigens;CD44 gene;Cell surface;Cell Survival;Cells;Cessation of life;Clinical;Complex;Couples;Cues;Data;Development;Developmental Process;Epithelial;Exclusion;Exons;extracellular;Feedback;Genetic Transcription;Goals;Growth Factor;Human;Hyaluronic Acid;Hyaluronic Acid Binding;IGF1R gene;in vivo;Ligand Binding;malignant breast neoplasm;Malignant Neoplasms;Mammary Neoplasms;MAP Kinase Gene;Mediating;Membrane Microdomains;Mesenchymal;Modeling;Molecular;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;palmitoylation;Pathogenesis;Patients;Play;Promotor (Genetics);Protein Family;Protein Isoforms;public health relevance;receptor;Receptor Protein-Tyrosine Kinases;Reporting;Research;RNA Splicing;Role;sensor;Signal Transduction;small hairpin RNA;Specimen;Testing;transcription factor;treatment strategy;tumor;Up-Regulation (Physiology),Investigating the mechanisms of CD44s splice isoform in breast cancer metastasis,182467,TPM,Tumor Progression and Metastasis Study Section,,,1,320588,
8653347,R01,CA,1,N,02/01/2014,02/01/2014,01/31/2015,393,R01CA183435,,PA-11-260,1R01CA183435-01,NCI:365200\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,07,078200995,US,FRED HUTCHINSON CAN RES CTR,WA,981091024,"PUBLIC HEALTH RELEVANCE: Merkel Cell polyomavirus (MCPyV) is clearly associated with a human tumor, Merkel Cell Carcinoma (MCC). We discovered a novel gene in MCPyV that we have called ALTO. Our goals are to understand the role of ALTO in the MCPyV lifecycle and how it affects tumorigenicity.            ",1863891;,"GALLOWAY, DENISE A.;","READ-CONNOLE, ELIZABETH LEE",02/01/2014,01/31/2019,Adenoviruses;Affect;Affinity Chromatography;Amino Acids;antigen binding;Antigens;Antithymoglobulin;Apoptosis;Autophagocytosis;Binding (Molecular Function);Biological Assay;cell growth;Cell Line;Cell Proliferation;cell transformation;Cellular Membrane;Chiroptera;Complementary DNA;Cytoskeleton;Data;Exons;Genes;Genome;Goals;Gorilla (species);Hamsters;helicase;Human;keratinocyte;Kinetics;Knock-out;Large T Antigen;Mass Spectrum Analysis;Membrane;Merkel cell carcinoma;Merkel Cells;Modeling;Molecular Chaperones;mouse polyomavirus;Mus;Mutate;Mutation;novel;Nucleotides;Oncogenes;Open Reading Frames;Pan Genus;Pathway interactions;Phosphorylation;Phosphotransferases;Phosphotyrosine;Plasmids;Polyomavirus;Polyomaviruses Large T Proteins;Process;Production;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;public health relevance;Raccoons;Reading Frames;Relative (related person);Retinoblastoma Protein;RNA Splicing;Role;SH2-Binding Motif;Signal Pathway;Signal Transduction;Simian virus 40;Site;Small T Antigen;Testing;Transfection;tumor;Tumor Suppressor Proteins;tumorigenesis;Tumorigenicity;Tyrosine Phosphorylation;Viral;Viral Tumor Antigens;Virion;Virus,The Role of ALTO in the MCPyV Lifecycle and Tumorigenicity,183435,ZRG1,Special Emphasis Panel,,,1,365200,
8693331,R01,DC,1,N,02/04/2014,02/05/2014,01/31/2015,173,R01DC013281,,PA-11-260,1R01DC013281-01A1,NIDCD:308734\,Research Projects,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BOYS TOWN,UNITED STATES,,02,073136806,US,FATHER FLANAGAN'S BOYS'HOME,NE,68010,"PUBLIC HEALTH RELEVANCE: The primary goal of this research project is to validate the use of telepractice for clinical measures that have not previously been evaluated for cochlear implant (CI) recipients, and to solve some of the problems that currently present barriers to implementation of telepractice for this population. Results from this project will advance the use of telepractice for clinical service delivery and expand access to specialized services for CI recipients, which should lead to improved outcomes.                ",7840821;,"HUGHES, MICHELLE L;","DONAHUE, AMY ",02/05/2014,01/31/2019,Adult;Age;age group;Area;Attention;Audiometry;Auditory;base;Behavioral;Belief;Child;Childhood;Clinic;Clinic Visits;Clinical;Clinical Services;Cochlear Implants;Communication;Computers;Devices;Electric Stimulation;Environment;Evidence based practice;Family;follow-up;Foundations;Goals;Healthcare;Hour;Implant;Improve Access;improved;Internet;Intervention;Laboratories;Lead;Life;Measures;medical specialties;Methods;metropolitan;Noise;novel;Outcome;Patients;Performance;Persons;Play;Population;programs;Property;Provider;Psychological reinforcement;public health relevance;Publishing;Qualifying;rehabilitation service;Rehabilitation therapy;Research;Research Project Grants;Research Support;Schools;Self-Administered;Services;Site;sound;Speech;Speech Perception;standard of care;Techniques;Technology;Telephone;Testing;Time;Transportation;Travel;Underserved Population;Visit;Visual;Work,TELEPRACTICE FOR COCHLEAR IMPLANTS,13281,ZRG1,Special Emphasis Panel,,A1,1,308734,
8697711,R01,DC,1,N,02/06/2014,02/06/2014,01/31/2015,173,R01DC013314,SCHOOLS OF MEDICINE,PA-11-260,1R01DC013314-01A1,NIDCD:355780\,Research Projects,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,ROOTSTOWN,UNITED STATES,ANATOMY/CELL BIOLOGY,16,077779882,US,NORTHEAST OHIO MEDICAL UNIVERSITY,OH,44272,"PUBLIC HEALTH RELEVANCE: In children, chronic middle ear infections (otitis media) that result in fluctuating hearing loss produce persistent deficits in auditory processing abilities, including speech perception. The resulting dysfunction in auditory cortex may play a critical role in these deficits, but the links between synaptic changes in cortex, their effects on cortical sound-evoked responses, and impaired perception are not known. By establishing these links, this work will identify which aspects of auditory signal processing are most at risk from early hearing loss, providing targets for intervention and remediation.            ",8723484;,"ROSEN, MERRI J;","PLATT, CHRISTOPHER ",02/06/2014,01/31/2019,Address;Adolescent;Adult;Affect;Age;Animal Model;Animals;Auditory;Auditory area;auditory deprivation;auditory stimulus;Auditory system;awake;base;Behavioral;Beryllium;Cells;Child;Chronic;computerized data processing;Conductive hearing loss;Control Animal;Data;deprivation;Detection;Development;Developmental Delay Disorders;Dyslexia;ear infection;early onset;Elements;Event;experience;Frequencies (time pattern);Functional disorder;Gerbils;Goals;Hearing;hearing impairment;Human;Impairment;Implanted Electrodes;Intervention;Link;Longevity;mature animal;Measures;middle ear;neuromechanism;Neurons;novel;Operant Conditioning;Otitis Media;Pathology;Perception;Performance;Periodicity;Phase;Play;postsynaptic;Process;Property;public health relevance;receptor;relating to nervous system;remediation;research study;response;Risk;Role;Sensory;Shapes;Signal Transduction;sound;specific language impairment;Speech;Speech Perception;speech processing;Stimulus;Synapses;Task Performances;Testing;theories;Therapeutic Intervention;Time;Training;Work,Auditory processing deficits in early-onset conductive hearing loss,13314,AUD,Auditory System Study Section,,A1,1,355780,
8659760,R01,DK,1,N,02/03/2014,02/05/2014,12/31/2014,847,R01DK099055,GRADUATE SCHOOLS,PA-11-260,1R01DK099055-01A1,NIDDK:336341\,Research Projects,2014,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,FORT WORTH,UNITED STATES,ANATOMY/CELL BIOLOGY,12,110091808,US,UNIVERSITY OF NORTH TEXAS HLTH SCI CTR,TX,761072699,"PUBLIC HEALTH RELEVANCE: Both HIV-1 and HCV are transmitted by shared routes of transmission, including blood transfusion, intravenous drug use, and sexual contact, and therefore a high percentage of these patients are doubly infected. Since liver disease is more severe in co-infected patients and since co-infection rates are high in Western countries, HCV has become a leading cause of morbidity and mortality among AIDS patients. This project is therefore intended to elucidate the role of HIV-1 and viral protein Nef in the progression of HCV-mediated liver disease, towards the development of prognostic biomarkers and therapies against this malady.            ",10323483;,"PARK, IN-WOO;","DOO, EDWARD ",02/05/2014,12/31/2017,Acceleration;Acquired Immunodeficiency Syndrome;adverse outcome;base;Biological;Biological Markers;Biological Process;Blood Transfusion;Boxing;Cell Line;Cell surface;Cells;cholesterol trafficking;Clinical;clinically relevant;Coculture Techniques;Complex;Country;Data;Detection;Deterioration;Development;Disease;Disease Progression;DNA;Ethanol;Fostering;Frequencies (time pattern);Genes;Genomics;Goals;Hepatitis C;Hepatitis C virus;Hepatocyte;HIV;HIV-1;Human;Immune;Indium;Indolent;Infection;intravenous drug use;Jurkat Cells;Lipids;Liver;Liver diseases;Malignant Neoplasms;Mediating;Mediation;Mitogen-Activated Protein Kinases;Molecular;Molecular Biology;Morbidity - disease rate;Mortality Vital Statistics;Natural History;nef Protein;outcome forecast;Pathogenesis;Patients;Phosphotransferases;Predisposition;Primary carcinoma of the liver cells;Production;Prognostic Marker;Proteins;public health relevance;Publications;Reactive Oxygen Species;Replicon;Reporting;Role;Route;Signaling Molecule;SR-BI receptor;Staging;success;T-Lymphocyte;Therapeutic;Tissue Sample;Tissues;tool;transmission process;Up-Regulation (Physiology);Viral;Viral Load result;Viral Proteins;Virus;Virus Replication,Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease,99055,ACE,AIDS Clinical Studies and Epidemiology Study Section,,A1,1,336341,
8632523,R01,EY,1,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY023371,SCHOOLS OF MEDICINE,PA-11-260,1R01EY023371-01A1,NEI:380500\,Research Projects,2014,NATIONAL EYE INSTITUTE,,CHICAGO,UNITED STATES,BIOLOGY,01,005421136,US,UNIVERSITY OF CHICAGO,IL,60637,PUBLIC HEALTH RELEVANCE: The long-term impact of this study on human health will be to aid the development of prosthetics that remediate deficits in central visual processing. This project could have a profound impact on our understanding of how the brain processes stimuli under natural conditions and for how we conceptualize sensory processing.                ,10301398;,"OSBORNE, LESLIE CAROL;","STEINMETZ, MICHAEL A.",02/01/2014,01/31/2019,Accounting;area MT;Automobile Driving;Behavior;Behavioral;Benchmarking;Brain;Code;Computer software;cost;Cues;Data;Development;digital;Dimensions;extracellular;extrastriate visual cortex;Eye;Eye Movements;eye velocity;Future;gaze;Goals;Health;Human;Image;Lateral Geniculate Body;Life;Light;Measures;Modeling;Monkeys;monocular;Motion;Motor;Movement;movie;neuromechanism;Neurons;Noise;Pathway interactions;Pattern;Performance;Peripheral;Population;Process;Prosthesis;Proxy;public health relevance;pursuit tracking;Reading;relating to nervous system;Research;research study;response;Retina;Retinal;Role;Rotation;Sensory;Sensory Process;Signal Transduction;simulation;Smooth Pursuit;software development;Source;Speed (motion);statistics;Stimulus;stimulus processing;Stream;Structure;Testing;Time;tool;Translating;Variant;Vision;Visual;visual adaptation;Visual Cortex;visual information;Visual Motion;visual motor;visual process;visual processing;Visual system structure;Work,Mechanisms of efficient coding of dynamic visual motion signals for pursuit,23371,SPC,,,A1,1,380500,
8612222,R01,EY,1,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY024028,SCHOOLS OF ARTS AND SCIENCES,PA-11-260,1R01EY024028-01,NEI:324000\,Research Projects,2014,NATIONAL EYE INSTITUTE,,BALTIMORE,UNITED STATES,NEUROSCIENCES,03,001910777,US,JOHNS HOPKINS UNIVERSITY,MD,21218,"PUBLIC HEALTH RELEVANCE: Our study will help explain the brain processing of large-scale shape information that underlies perception of scenes, landscapes, and building interiors. The results will help guide future rehabilitative and prosthetic strategies for patients with compromised visual navigation due to blindness or stroke-induced agnosias.                ",1880966;,"CONNOR, CHARLES E;","STEINMETZ, MICHAEL A.",02/01/2014,01/31/2018,Agnosia;Area;base;Biological;Blindness;Brain;Brain imaging;brain pathway;Cells;Characteristics;Code;comparative;Complement;Complex;Computer Simulation;computerized;Data;Data Set;Diagnostic;Elements;eye center;Face;Force of Gravity;Functional Imaging;Future;Genetic Programming;Homologous Gene;Human;Individual;Investigation;Lead;Maps;mathematical model;Measures;Medial;Memory;Metric;Modeling;Monkeys;Movement;Neurons;novel;Pathway interactions;Patients;Perception;Positioning Attribute;Process;Prosthesis;public health relevance;Rehabilitation therapy;relating to nervous system;Relative (related person);Research;response;Role;Sampling;Shapes;Staging;statistics;Stimulus;Stream;stroke;Structure;Surface;three dimensional structure;Three-dimensional analysis;Vision;Visual;Visual Cortex;visual information;Visual Pathways;Visual Perception;visual process;visual processing,Neural Coding of 3D Object and Place Structure in Two Cortical Pathways,24028,SPC,,,,1,324000,
8614522,R01,EY,1,N,02/01/2014,02/01/2014,01/31/2015,867,R01EY024045,SCHOOLS OF MEDICINE,PA-11-260,1R01EY024045-01,NEI:385730\,Research Projects,2014,NATIONAL EYE INSTITUTE,,IRVINE,UNITED STATES,ANATOMY/CELL BIOLOGY,48,046705849,US,UNIVERSITY OF CALIFORNIA-IRVINE,CA,926977600,"PUBLIC HEALTH RELEVANCE: Patients with advanced degenerative diseases need replacement of both retinal pigment epithelium (RPE) and photoreceptors. Our hypothesis is that human embryonic stem cells, differentiated into layered sheets of retinal progenitor and RPE cells, can integrate with the host and restore visual responses in a new rat model of retinal degeneration that does not reject human cells. This will ultimately help to restore vision in patients with retinal degeneration.            ",6623824;,"KEIRSTEAD, HANS S;","NEUHOLD, LISA ",02/01/2014,01/31/2017,3-Dimensional;Address;Animal Experimentation;Area;base;Basic Science;blastocyst;Blindness;cell type;Cells;Clinical;Clinical Research;Clinical Trials;Contrast Sensitivity;Data;Degenerative Disorder;dehydroretinal;Development;Electrophysiology (science);experience;fetal;functional restoration;Funding;Future;Generations;Grant;Harvest;Human;human embryonic stem cell;Immunohistochemistry;Implant;improved;induced pluripotent stem cell;instrument;Investigational Drugs;Investigational New Drug Application;Laboratories;Lead;light intensity;Methods;Modeling;monolayer;Morphology;nerve stem cell;Nurse's Role;oligodendrocyte precursor;Opsin;optic cup;Optic vesicle;Patients;photoreceptor progenitor;Photoreceptors;pluripotency;Pluripotent Stem Cells;Positioning Attribute;pre-clinical;Procedures;programs;Protocols documentation;public health relevance;Publications;Rattus;recoverin protein;repaired;Research;Research Personnel;response;restoration;Retina;Retinal;Retinal Cone;Retinal Degeneration;Retinal Diseases;retinal progenitor cell;Rhodopsin;Rodent Model;sham surgery;Source;Spinal cord injury;stem cell population;Stem cell transplant;Stem cells;Structure;Structure of retinal pigment epithelium;success;superior colliculus Corpora quadrigemina;Synapses;Testing;Therapeutic Human Experimentation;Tissue Donors;Tissues;transcription factor;Translating;Transplantation;United States Food and Drug Administration;Vision;Visual;Visual Acuity;Work,3D retina-RPE constructs for vision restoration in new rat retinal degeneration m,24045,DPVS,,,,1,385730,
8605019,R01,GM,1,N,02/06/2014,02/06/2014,11/30/2014,859,R01GM103600,,RFA-GM-14-001,1R01GM103600-01A1,NIGMS:370486\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,OAK RIDGE,UNITED STATES,,03,099114287,US,"UT-BATTELLE, LLC-OAK RIDGE NATIONAL LAB",TN,378312008,"PUBLIC HEALTH RELEVANCE: The developing infant gut is an ideal model system that can be used to uncover general features of gut microbial community function, and to clarify the relationships between aberrant function and inflammation. Intestinal inflammatory disorders, such as necrotizing enterocolitis or Crohn's Disease, can result from exaggerated immune responses;however, it is unclear whether microbiome shifts precede inflammation, or are a consequence of it. The goal of this project is to conduct time-series whole community proteomic analyses of the model ecosystem, the newborn intestinal tract, in order to characterize links between dysbiosis and intestinal inflammation.                 ",9869042;2215578 (contact);9420334;,"BANFIELD, JILLIAN;HETTICH, ROBERT L (contact);MOROWITZ, MICHAEL;","SLEDJESKI, DARREN D.",02/06/2014,11/30/2017,Adult;Aerobic;Anti-inflammatory;Anti-Inflammatory Agents;Attention;base;Biochemical Process;Bioinformatics;Biological Markers;Biological Models;Biology;Carbon;Communities;Companions;Crohn's disease;Data;Data Analyses;Data Set;Development;Disease;Ecosystem;Epithelial;Fermentation;Generations;Genes;Goals;Health;Human;Human body;Human Microbiome;Hydrogen;Immune response;improved;Infant;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory disease of the intestine;Inflammatory Response;Informatics;interest;Intestinal Diseases;intestinal homeostasis;Intestines;Investigation;knowledge base;Life;Link;link protein;Maintenance;Mass Spectrum Analysis;Measurement;Measures;Metabolic Pathway;Metabolism;Metagenomics;Methods;Microbe;microbial;microbial colonization;microbial community;microbiome;Modeling;Monitor;Natural Immunity;Necrotizing Enterocolitis;Newborn Infant;Nitrogen;novel;Onset of illness;Organism;Oxidation-Reduction;Pathogenesis;Pathway interactions;Pattern;Premature Infant;Production;protein expression;Proteins;Proteome;Proteomics;public health relevance;Research;Resolution;Respiration;Sampling;Series;Study models;Sulfur Metabolism Pathway;System;Testing;Time;tool;United States National Institutes of Health;Virulence Factors;Volatile Fatty Acids;Work,Proteogenomic analysis of inflammation and dysbiosis in the infant gut,103600,ZGM1,Special Emphasis Panel,,A1,1,370486,
8605797,R01,GM,1,N,02/06/2014,02/06/2014,12/31/2014,859,R01GM108527,,RFA-GM-14-001,1R01GM108527-01,NIGMS:440230\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,49,020520466,US,SANFORD-BURNHAM MEDICAL RESEARCH INSTIT,CA,920371005,"PUBLIC HEALTH RELEVANCE: Our proposed study will elucidate the extent that resilience of microbial communities is driven by syntrophic metabolism of vitamins, precursors of essential co-factors, and whether changes in the dietary supply of such vitamins modulates the population structure and functional expression of gut microbial communities.                    ",8870144;,"PETERSON, SCOTT NORMAN;","SLEDJESKI, DARREN D.",02/06/2014,12/31/2017,Adopted;Anabolism;auxotrophy;Bacteroides;base;Behavior;Biogenesis;Bioinformatics;Carbon;Classification;Coculture Techniques;Coenzyme A;Coenzymes;cofactor;Commit;Communities;Computer Simulation;Data;Dependency (Psychology);Diet;Dose;Energy-Generating Resources;Ensure;Equilibrium;Evolution;feeding;fitness;Flavin Mononucleotide;Frequencies (time pattern);Genome;Genomics;Gnotobiotic;Growth;gut microbiota;Homeostasis;Human;In Vitro;insight;Intake;interest;Knowledge;Lead;Life Style;Measurement;member;Metabolic;Metabolism;metabolomics;Microbe;microbial;microbial community;Modeling;Molecular;Molecular Profiling;Mus;mutualism;Nature;Nicotinic Acids;Nutrient;pantothenate;Pathway interactions;Phenotype;Play;Population;predictive modeling;pressure;Prevalence;public health relevance;pyridoxine;Recombinant DNA;reconstruction;Relative (related person);resilience;Resistance;response;Riboflavin;Role;Source;Structure;Systems Analysis;Systems Biology;Thiamine;Transcriptional Regulation;transcriptomics;uptake;Validation;Variant;Vitamin B Complex;vitamin biosynthesis;vitamin metabolism;Vitamins,Syntrophy in Metabolism of B-Vitamins in Gut Microbial Communities,108527,ZGM1,Special Emphasis Panel,,,1,440230,
8654226,R01,HD,1,N,02/06/2014,02/07/2014,01/31/2015,865,R01HD075549,SCHOOLS OF MEDICINE,PA-11-260,1R01HD075549-01A1,NICHD:336028\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,AURORA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"PUBLIC HEALTH RELEVANCE: Hepatitis C is an RNA virus that infects approximately 200 million throughout the world. In the U.S. alone, it is estimated that approximately 40,000 births occur annually in HCV-positive pregnant women. HCV infection is associated with an increased risk for pre-term delivery, perinatal mortality, intrauterine growth restriction, and other complications;furthermore, vertical transmission accounts for the majority of pediatric HCV cases. Remarkably little is known about the mechanisms that govern transmission or protection for the fetus. We propose to study the integration and nature of multi-cellular immune responses within the maternal-fetal interface.            ",6158535;1900124 (contact);,"PETROFF, MARGARET G;ROSEN, HUGO RAMON (contact);","REDDY, UMA M",02/07/2014,01/31/2019,Accounting;adaptive immunity;Antigen-Presenting Cells;Antiviral Agents;Antiviral Response;Apoptosis;Avidity;Beds;Birth;Blood;Blood flow;CD28 gene;CD8B1 gene;Cells;Child;Childhood;Chronic;Chronic Hepatitis C;Clinical;cohort;Collaborations;Containment;Cross Presentation;cross reactivity;cytotoxic;Decidua;Dendritic Cells;Development;Employee Strikes;Event;Evolution;Fetal Growth Retardation;fetal medicine;Fetus;Flow Cytometry;Genes;genetic association;Genome;Hepatitis C;Hepatitis C Transmission;Hepatitis C virus;HIV;Human;Immune;Immune response;Immunity;Immunology;Immunotherapeutic agent;Individual;Infection;insight;Interferons;Laboratories;Maternal-Fetal Exchange;Mediating;Memory;Modeling;Molecular;Mothers;National Institute of Child Health and Human Development;natural Blastocyst Implantation;Natural Immunity;Nature;novel;particle;pathogen;Patients;Pattern;Pattern recognition receptor;Peptides;Perinatal Exposure;Perinatal mortality demographics;peripheral blood;Phenotype;Placenta;Play;Population;Pregnancy;Pregnant Women;pressure;Prevalence;prevent;Property;public health relevance;Recovery;response;Risk;RNA Viruses;Role;self-renewal;SELL gene;Signal Transduction;Single Nucleotide Polymorphism;Small Interfering RNA;Stem cells;T-Lymphocyte;T-Lymphocyte Subsets;Termination of pregnancy;Testing;Time;transmission process;Tretinoin;trophoblast;Umbilical Cord Blood;United States;Uterus;Variant;Vertical Disease Transmission;Viral;Viral Antigens;Viral Proteins;viral RNA;Viremia;Virus;Virus Diseases;Woman;Work,INNATE AND ADAPTIVE IMMUNITY TO HCV IN HUMAN PREGNANCY,75549,IHD,Immunity and Host Defense,,A1,1,336028,
8626617,R01,HL,1,N,02/01/2014,02/01/2014,01/31/2015,837,R01HL117829,,PA-11-260,1R01HL117829-01A1,NHLBI:387439\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,07,073130411,US,MASSACHUSETTS GENERAL HOSPITAL,MA,02199,"PUBLIC HEALTH RELEVANCE: We will test the hypothesis that myeloid cells recruited to the heart instigate left ventricular remodeling after coronary ligation in mice. We will study leukocyte's presence, phenotype, subsets and their impact on disease progression. We investigate how monocytes/macrophages instruct parenchymal cardiac cells during evolution of heart failure, including fibroblasts, myocytes, and endothelial cells.                ",9482283;,"NAHRENDORF, MATTHIAS;","DESVIGNE-NICKENS, PATRICE ",02/01/2014,01/31/2018,Angiotensins;Apoptosis;Atherosclerosis;Attenuated;Autoimmune Diseases;base;Behavior;Bone Marrow;Candidate Disease Gene;Cardiac;Cause of Death;Cell Adhesion Molecules;cell behavior;Cell Communication;Cells;chemokine;chemokine receptor;Chronic;Clinical;Coronary;cytokine;Data;Dendritic Cells;Digestion;Disease Progression;Endothelial Cells;Evolution;Extracellular Matrix;Extracellular Matrix Degradation;Extramedullary;Fibroblasts;Fibrosis;Flow Cytometry;Fluorescence;Fluorescence Microscopy;Gene Expression;Generations;Heart;Heart failure;Hypertrophy;Image;Immune;in vivo;Infarction;Inflammation;Inflammatory;intravital fluorescence microscopy;intravital microscopy;Invaded;ITGAM gene;knock-down;Left Ventricular Remodeling;Leukocytes;Ligation;Lymphocyte;macrophage;Magnetic Resonance Imaging;Measures;Messenger RNA;Molecular;molecular pathology;Molecular Profiling;monocyte;Mus;Muscle Cells;Myeloid Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Myofibroblast;nanoparticle;neutrophil;novel;novel therapeutics;Patients;Peptide Hydrolases;Phenotype;Positioning Attribute;Process;Production;progenitor;public health relevance;Recruitment Activity;Reporting;RNA Interference;Role;Signal Transduction;Site;Small Interfering RNA;Source;Sympathetic Nervous System;Technology;Testing;Therapeutic Effect;Time;Tissues;tomography;trafficking;Ventricular,Cell-Cell Interaction in Heart Failure,117829,MIM,Myocardial Ischemia and Metabolism Study Section,,A1,1,387439,
8630169,R01,HL,1,N,02/03/2014,02/04/2014,01/31/2015,837,R01HL117888,SCHOOLS OF MEDICINE,PA-11-260,1R01HL117888-01A1,NHLBI:420616\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,07,005436803,US,NORTHWESTERN UNIVERSITY AT CHICAGO,IL,60611,"PUBLIC HEALTH RELEVANCE: We propose to develop a multi-modality imaging protocol for the non-invasive characterization of tissue and function of the left and right heart in patients after heart transplantation. Our aim is to develop a new non- invasive 15 minute diagnostic test in order to provide a previously unattainable quantitative characterization of myocardial structure-function deficits in cardiac transplant patients. The application in a longitudinal clinial study coupled with cost-effectiveness analysis and decision tree modeling will allow to improve current monitoring strategies by combining cardiac MRI, echocardiography, intravascular ultrasound and invasive tests (biopsy, catheter angiography) to provide the best outcome (quality of life days, mortality) and lowest cost for the individual cardiac transplant patient.            ",8668310;10792462 (contact);,"CARR, JAMES;MARKL, MICHAEL  (contact);","SHAH, MONICA R",02/04/2014,01/31/2018,Acute;Allografting;Ambulatory Care Facilities;Angiography;Area;base;Biopsy;Blood Vessels;Cardiac;Caring;Catheters;Cause of Death;Clinical;Clinical Research;comparative;Coronary;Coronary Angiography;cost;cost effectiveness;Cost Effectiveness Analysis;Coupled;Data;Decision Modeling;Decision Trees;Detection;Diagnostic;Diagnostic tests;Diffuse;Disease;Early Diagnosis;Echocardiography;Edema;Evaluation;Event;extracellular;Fibrosis;follow-up;Functional disorder;Goals;Gold;Healthcare;Heart;heart allograft;Heart Transplantation;Image;imaging modality;Impairment;improved;Individual;Left;Life;Longitudinal Studies;Magnetic Resonance Imaging;Maps;markov model;Modality;Modeling;Monitor;Mortality Vital Statistics;Myocardial;Nature;novel;Operative Surgical Procedures;Outcome;Patient Monitoring;Patients;Perfusion;Phase;Procedures;Protocols documentation;public health relevance;Quality of life;Reference Standards;Resources;Risk;Risk Factors;Risk Marker;Sampling Errors;Sensitivity and Specificity;Structure;Techniques;Testing;Thick;Time;Tissues;Transplant Recipients;Transplantation;two-arm study;Ultrasonography;Vascular Diseases;Visit,Comprehensive Cardiac Structure-Function Analysis in Heart Transplantation,117888,MEDI,Medical Imaging Study Section,,A1,1,420616,
8632342,R01,HL,1,N,02/01/2014,02/01/2014,01/31/2015,837,R01HL118313,SCHOOLS OF MEDICINE,PA-11-260,1R01HL118313-01A1,NHLBI:335250\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SALT LAKE CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,009095365,US,UNIVERSITY OF UTAH,UT,84112,"PUBLIC HEALTH RELEVANCE: Heart disease is the leading cause of death in the United States, accounting for one in every four deaths in 2010 and costing over $300 billion annually in health care, medication, and lost productivity. The proposed project seeks to examine the mechanisms leading to chronic peripheral vasoconstriction in HF, with the hope that this knowledge will improve the level of physical activity and reduce symptoms in these patients. Findings from these studies may thus serve to refine important aspects of clinical care in HF, ultimately leading to enhanced quality of life and reduced morbidity and mortality in this cohort.           ",11362628;,"WRAY, DAVID WALTER;","DESVIGNE-NICKENS, PATRICE ",02/01/2014,01/31/2019,"Acceleration;Accounting;Acute;Address;adrenergic;Adrenergic Agents;Adrenergic alpha-Agonists;Adrenergic alpha-Antagonists;Affect;Age;Aldosterone;alpha-adrenergic receptor;American;Angiotensins;Antioxidants;Ascorbic Acid;Biological Availability;Blood Circulation;Blood flow;Cardiac;Cause of Death;Cessation of life;Chronic;Clinical;clinical care;cohort;cost;Disease;Disease Progression;Etiology;Exercise;Exhibits;Free Radicals;Functional disorder;Goals;Healthcare;Heart Diseases;Heart failure;improved;Individual;Influentials;Infusion procedures;inhibitor/antagonist;innovation;Intervention;Knowledge;Limb structure;Mediating;Methodology;Morbidity - disease rate;Mortality Vital Statistics;Muscle;Muscle, Smooth, Vascular;Nerve;Nitric Oxide;Nitric Oxide Pathway;Norepinephrine;novel therapeutic intervention;Oral;Oxidative Stress;Pathway interactions;Patient Care;patient population;Patients;Peripheral;peripheral blood;Pharmaceutical Preparations;Pharmacotherapy;Physical activity;Productivity;public health relevance;Quality of life;Receptors, Adrenergic, alpha-2;Renin;Research;research study;response;Rest;restraint;Role;Series;Skeletal muscle structure;Supplementation;Sympathetic Nervous System;Symptoms;Syndrome;Systolic heart failure;Thioctic Acid;treatment strategy;United States;Vascular constriction (function);Vascular Endothelium;Vasoconstrictor Agents;Vasodilation;Vasodilator Agents;Work",Peripheral Vasoconstriction in Heart Failure: Mechanisms &Modulatory Influences,118313,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,A1,1,335250,
8639259,R01,HL,1,N,02/01/2014,02/03/2014,01/31/2015,837,R01HL118369,SCHOOLS OF MEDICINE,PA-11-260,1R01HL118369-01A1,NHLBI:427117\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,DUKE UNIVERSITY,NC,27705,"PUBLIC HEALTH RELEVANCE:  Atherosclerosis remains a leading cause of death in the United States. In determining cellular and molecular mechanisms by which the protein USP20 protects against atherosclerosis, this project should identify gene products and molecular mechanisms that may serve as novel therapeutic targets for treating humans with atherosclerosis.            ",1895224;8040667 (contact);,"FREEDMAN, NEIL J.;SHENOY, SUDHA K (contact);","OLIVE, MICHELLE ",02/03/2014,01/31/2018,Affect;Anti-inflammatory;Anti-Inflammatory Agents;Antiatherogenic;Antibodies;atherogenesis;atheroprotective;Atherosclerosis;base;Binding (Molecular Function);Blood Vessels;Breeding;Cause of Death;cell motility;Cell Proliferation;congenic;Custom;cytokine;Cytokine Receptors;Deubiquitination;Diet;feeding;G-Protein-Coupled Receptors;Gene Expression;Genes;Goals;Growth Factor Receptors;Human;Hyperplasia;In Vitro;in vivo;Inflammatory;interleukin-1 receptor-associated kinase;Interleukin-1 Receptors;Ion Channel;Ions;IRAK1 gene;Link;MAPK3 gene;Mediating;Methods;migration;Modeling;Molecular;Mus;new therapeutic target;novel;Phosphorylation;Phosphotransferases;Physiological;Polyubiquitination;Post-Translational Protein Processing;Preparation;prevent;Process;Promotor (Genetics);Protein Dephosphorylation;Protein Isoforms;Proteins;prototype;public health relevance;Reagent;Regulation;response;Role;scaffold;Signal Transduction;Signaling Protein;Smooth Muscle Myocytes;Stimulus;stress-activated protein kinase 1;System;Techniques;Testing;TNF gene;toll-like receptor 4;TRAF2 gene;TRAF6 gene;transcription factor;Transgenic Mice;Tumor Necrosis Factor Receptor;ubiquitin-protein ligase;ubiquitin-specific protease;Ubiquitination;United States,Regulation of B-arrestin2's pro-atherogenic activity by the deubiquitinase USP20,118369,VCMB,Vascular Cell and Molecular Biology Study Section,,A1,1,427117,
8630004,R01,HL,1,N,02/04/2014,02/03/2014,01/31/2015,837,R01HL118430,SCHOOLS OF MEDICINE,PA-11-260,1R01HL118430-01A1,NHLBI:374625\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,YALE UNIVERSITY,CT,065208047,"PUBLIC HEALTH RELEVANCE: Excessive growth of vascular smooth muscle cells (VSMC) contributes to atherosclerosis, as well as to failure of the procedures (angioplasty/stenting, bypass surgery) that restore blood flow through atherosclerotic vessels. Our goal is to understand why VSMC grow excessively, in order to develop better and safer agents for prevention and therapy of cardiovascular diseases. We have discovered a new pathway that alters DNA in VSMC, and may be an important target for future therapies.            ",8826565;,"MARTIN, KATHLEEN ANN;","OLIVE, MICHELLE ",02/03/2014,01/31/2018,Accounting;Angioplasty;Atherosclerosis;Biology;Blood flow;Blood Vessels;Bypass;c-myc Genes;Cardiovascular Diseases;Cardiovascular system;Cell Cycle;cell dedifferentiation;Cell Differentiation process;Cellular biology;Chromatin;Complement;Data;DNA;DNA Methylation;Embryo;Epigenetic Process;Failure (biologic function);Family;femoral artery;Future;Gene Expression;Genes;Goals;graft failure;Growth;Growth Factor;Healed;healing;Hematopoietic stem cells;Hyperplasia;improved;In Vitro;in vivo;in vivo Model;Individual;inhibitor/antagonist;Injury;Knock-out;Knockout Mice;Lead;Mediating;Mediator of activation protein;MicroRNAs;Modeling;Molecular;Molecular Conformation;myocardin;novel;Operative Surgical Procedures;overexpression;Pathology;Pathway interactions;Patients;Phenotype;Platelet-Derived Growth Factor;pluripotency;Prevention therapy;Procedures;Process;programs;Promotor (Genetics);Proteins;public health relevance;Regulation;response;restenosis;Role;Sampling;Sirolimus;Smooth muscle (tissue);Smooth Muscle Myocytes;stem cell differentiation;Stem Cell Factor;Stem cells;Testing;Therapeutic;Transplantation;Vascular Diseases;Viral,Regulation of vascular smooth muscle cell plasticity,118430,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",,A1,1,374625,
8629353,R01,NR,1,N,02/05/2014,02/05/2014,01/31/2015,361,R01NR014221,SCHOOLS OF NURSING,PA-11-260,1R01NR014221-01A1,NINR:614054\,Research Projects,2014,NATIONAL INSTITUTE OF NURSING RESEARCH,,PITTSBURGH,UNITED STATES,OTHER HEALTH PROFESSIONS,14,004514360,US,UNIVERSITY OF PITTSBURGH,PA,15213,"PUBLIC HEALTH RELEVANCE: Data from the proposed study will serve to increase understanding of the complication of myocardial injury after subarachnoid hemorrhage (SAHMI) and its consequences, and permit our development of clinically practicable perfusion goal-directed therapeutic recommendations to support patients and minimize the development of physical and neuropsychological functional disability.            ",7959479;7366567 (contact);,"FRIEDLANDER, ROBERT M.;HRAVNAK, MARILYN  (contact);","MATOCHA, MARTHA F.",02/05/2014,01/31/2018,21 year old;adverse outcome;Affect;Aneurysmal Subarachnoid Hemorrhages;Arrhythmia;Automobile Driving;base;Cardiac;Cardiac Output;care systems;Caring;Cerebral Ischemia;Cerebral perfusion pressure;Cerebrovascular Spasm;Cerebrum;Cessation of life;Characteristics;Classification;Clinical;Complication;Congenital Heart Defects;Data;Depressed mood;Development;disability;Echocardiography;EFRAC;Electrocardiogram;evidence based guidelines;Exhibits;experience;FDA approved;functional disability;functional outcomes;Goals;hemodynamics;Holter Electrocardiography;Hospitalization;Impairment;improved;Injury;innovation;Intensive Care;IV Fluid;Lead;Length of Stay;Measures;Modality;Modeling;Monitor;Motion;Myocardial;Near-Infrared Spectroscopy;Neurologic;neuropsychological;Neuropsychology;novel;Nurses;Outcome;Outcome Assessment (Health Care);Patient Care;Patients;Perfusion;Peripheral;Physical Function;Positioning Attribute;public health relevance;Pulmonary Edema;Recommendation;Recovery;Recovery of Function;Recruitment Activity;Resources;Severities;Societies;Subarachnoid Hemorrhage;Technology;Therapeutic;Trees;Troponin I;Work,Developing Goal Directed Perfusion Therapy in SAH Neurocardiac Injury,14221,NRCS,Nursing and Related Clinical Sciences Study Section,,A1,1,614054,
8689281,R03,DC,1,N,02/04/2014,02/07/2014,01/31/2015,173,R03DC013388,,PAR-13-057,1R03DC013388-01A1,NIDCD:164000\,Research Projects,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BOSTON,UNITED STATES,,08,073825945,US,MASSACHUSETTS EYE AND EAR INFIRMARY,MA,021143002,"PUBLIC HEALTH RELEVANCE: The experiments in the current proposal seek to understand how the brain represents the location of a sound source, particularly in everyday environments which contain multiple, overlapping sources of sound. The experiments also seek to isolate deficits in the neural processing of sound location of individuals with sensorineural hearing loss-a common form of hearing loss which is known to degrade sound localization ability.                ",7894662;,"DAY, MITCHELL L;","PLATT, CHRISTOPHER ",02/07/2014,01/31/2017,Acoustic Trauma;Address;Animals;Auditory;Auditory Brainstem Responses;auditory pathway;Auditory system;awake;base;Bilateral;Bilateral Hearing Loss;Brain;Brain Stem;Cell Nucleus;Code;Comprehension;Cues;Data;Ear structure;early onset;Environment;Hearing;hearing impairment;Human;Individual;Inferior Colliculus;interest;Location;Measures;Modality;neuromechanism;Neurons;Noise;Oryctolagus cuniculus;Pattern;Performance;Population;Process;Property;Psychophysics;public health relevance;relating to nervous system;research study;response;Scientist;Sensorineural Hearing Loss;Sensory;sensory system;sound;Sound Localization;Source;Speech;Stimulus;Testing;Time;Training,Neural coding of sound location under normal and impaired hearing conditions,13388,CDRC,Communication Disorders Review Committee,,A1,1,164000,
8681727,R03,DK,1,N,02/05/2014,02/05/2014,01/31/2015,847,R03DK099562,SCHOOLS OF MEDICINE,PAR-12-285,1R03DK099562-01A1,NIDDK:81000\,Research Projects,2014,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,SURGERY,03,001910777,US,JOHNS HOPKINS UNIVERSITY,MD,21218,"PUBLIC HEALTH RELEVANCE: Colorectal cancer is the second leading cause of death for men and women in the United States and hence, is a major public health problem for which there are no clear preventive measures. The role of infectious and inflammatory processes in colon carcinogenesis is of intense interest because the colon is colonized with vast numbers of bacteria. Understanding the potential mechanisms by which bacteria may contribute to the pathogenesis of colorectal cancer will open new opportunities for colorectal cancer screening, prevention and treatment.            ",10040542;,"WICK, ELIZABETH C;","PODSKALNY, JUDITH M,",02/05/2014,01/31/2016,Acute;Adhesions;Affect;Antibiotics;Azoxymethane;Bacteria;Bacteroides fragilis;base;Binding (Molecular Function);C57BL/6 Mouse;Cause of Death;Cell Communication;Cells;Chronic;Colitis;Colon;colon carcinogenesis;Colonic Neoplasms;Colorectal Cancer;colorectal cancer screening;Combined Antibiotics;commensal microbes;Complement;Data;defined contribution;design;Development;E-Cadherin;Epithelial;Epithelial Cells;Epithelial Receptor Cell;Generations;Goals;homeobox protein PITX1;Human;IL17 gene;Immune;Immune response;In Vitro;in vivo;Inflammation;Inflammatory;innovation;interest;Interleukin-17;Intestinal Neoplasms;Knock-out;Knockout Mice;Laboratories;Manuscripts;Marrow;Measures;Mediating;men;Mentors;Metalloproteases;microbiome;Modeling;Molecular;mouse model;Mus;novel;Oncogenic;Organism;outcome forecast;Pathogenesis;Pathway interactions;Permeability;Prevention;Prevention strategy;Preventive;Process;Property;protein E;public health medicine (field);public health relevance;receptor;Receptor Signaling;research study;response;Role;Severities;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Sodium Dextran Sulfate;Staging;Testing;Toll-like receptors;Toxin;transcription factor;Transplantation;treatment strategy;tumor;tumor initiation;tumorigenesis;United States;Virulence Factors;Woman;Work,Role of Stat3 in ETBF Mediated Colitis and Tumor Initiation,99562,DDK,Digestive Diseases and Nutrition C Subcommittee,,A1,1,81000,
8683551,R03,DK,1,N,02/03/2014,02/03/2014,01/31/2015,847,R03DK101847,SCHOOLS OF MEDICINE,PAR-12-285,1R03DK101847-01,NIDDK:83250\,Research Projects,2014,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,YALE UNIVERSITY,CT,065208047,"PUBLIC HEALTH RELEVANCE: At sites of tissue injury of any kind, there occurs a rapid immune response termed the innate immune response which we have shown can induce further tissue injury, organ failure, morbidity, and mortality in liver and pancreatic injury. The mechanisms responsible for resolving this inflammatory state are unknown. We seek to further understand and characterize our preliminary finding that glycolytic metabolites produced at sites of tissue injury and their recently identified cell surface receptors suppress innate immune response mediated tissue injury in acute liver injury and acute pancreatitis.            ",9738839;,"HOQUE, RAFAZ;","PODSKALNY, JUDITH M,",02/03/2014,01/31/2016,Acetaminophen;Acute;acute pancreatitis;Agonist;Anti-inflammatory;Anti-Inflammatory Agents;ARRB2;beta-Hydroxybutyrate;Biological Assay;Caerulein;cell injury;Cell surface;Cell Surface Receptors;Cells;Cytoprotective Agent;Data;Functional disorder;G-Protein-Coupled Receptors;Galactosamine;Glycolysis;Heme Oxygenase (Decyclizing);Hepatitis;Immune;immune activation;Immune response;Immune system;In Vitro;in vivo;in vivo Model;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;Knockout Mice;Kupffer Cells;Ligands;Liver;liver injury;macrophage;Mediating;Metabolism;Modeling;Molecular;Morbidity - disease rate;Mortality Vital Statistics;Mus;Nicotinic Acids;Organ;Organ failure;Pancreas;Pancreatic Injury;Pancreatitis;Pathway interactions;Pattern;Peritoneal;Peritoneal Macrophages;Phenotype;Process;Proteins;public health relevance;receptor;Regulation;Resolution;response;Rodent Model;Role;Signal Transduction;Site;Sterility;Supplementation;Tissues;TLR4 gene;toll-like receptor 4;transcription factor;Work,GPR81 &GPR109a Regulate Innate Immune Injury in Sterile Inflammation,101847,DDK,Digestive Diseases and Nutrition C Subcommittee,,,1,83250,
8691543,R13,FD,1,N,09/05/2013,09/10/2013,08/31/2014,,R13FD004960,,PAR-13-200,1R13FD004960-01,,Other Research Related,2013,FOOD AND DRUG ADMINISTRATION,,LANSING,UNITED STATES,,08,805335577,US,MICHIGAN STATE DEPT OF AGRICULTURE,MI,48933," PROJECT NARRATIVE The Michigan Food Protection Task Force Conference grant will support a series of food safety and food security meetings which provide a forum to foster and facilitate communication and cooperation among Michigan stakeholders, including state, local, tribal public health and other public and private food safety agencies. The Food Safety Alliance will address food safety and food security issues, and FSMA, of interest to a broad range of stakeholders, including ways to integrate resources and clarify responsibilities to enhance the statewide food protection and defense system to maximize the protection of public health. The MI Food &Agriculture Protection &Defense Working Group oversees the further development and refinement of Michigan's Food and Agricultural Protection Strategy and FDA's Food Protection Plan and is essential to effectively prepare for a wide range of hazards and build emergency preparedness with specific focus on prevention, intervention and response.",10970255;,"BESEY, KEVIN;",,09/10/2013,08/31/2018,,MI Food Protection Task Force Conference,4960,ZFD1,Special Emphasis Panel,,,1,,
8710766,R13,HS,1,N,02/05/2014,02/05/2014,01/31/2015,226,R13HS023045,,PA-13-017,1R13HS023045-01,,Other Research Related,2014,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,MC LEAN,UNITED STATES,,10,611313719,US,ACADEMIC PEDIATRIC ASSOCIATION,VA,22101,"PUBLIC HEALTH RELEVANCE: Although the importance of quality improvement (QI) for pediatric health care has been established, evidence on the effectiveness of specific pediatric QI interventions remains sparse. These conferences seek to disseminate and advance state-of-the-art research methods for QI research relevant to pediatric care, and facilitate networking and collaboration at the national level. The ultimate goal of these conferences is to further develop the science of pediatric QI research in support of improved child health and health care.",1911916;,"FINKELSTEIN, JONATHAN A;","AZAM, IRIM ",02/05/2014,01/31/2017,,Advancing Quality Improvement Science for Childrens Health Care Research,23045,HSQR,,,,1,,
8714307,R13,NS,1,N,02/06/2014,02/15/2013,12/31/2014,853,R13NS087696,,PA-12-212,1R13NS087696-01,NINDS:15000\,Other Research Related,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WEST KINGSTON,UNITED STATES,,02,075712877,US,GORDON RESEARCH CONFERENCES,RI,02892,"PUBLIC HEALTH RELEVANCE:   The basal ganglia are a collection of brain regions intimately involved in a range of neurological diseases, including Parkinson disease, Huntington disease, dystonia, Tourette's syndrome and schizophrenia. The growing awareness of their clinical importance and the rapid expansion of experimental tools available for their study have led to an explosion in basal ganglia research in the last decade This conference brings together world leaders in the study of these regions to brainstorm about current research and ways of translating our understanding into new treatments for disease.                 ",1904871;,"SURMEIER, DALTON JAMES;","SIEBER, BETH-ANNE ",02/15/2013,12/31/2014,abstracting;Address;Affect;Age;Animals;Area;Asia;Awareness;Basal Ganglia;Basal Ganglia Diseases;Brain region;California;career;Cell Nucleus;Clinical;Collaborations;Collection;Communities;cost;design;Disease;Dystonia;Enrollment;Environment;Ethnicity aspects;Europe;Event;Explosion;Faculty;Fostering;Functional disorder;Future;Gender;Geographic Locations;Gilles de la Tourette syndrome;Goals;Growth;Huntington Disease;International;Laser Microscopy;Lead;Location;Maps;meetings;Middle East;Movement;nervous system disorder;Neurosciences;new technology;North America;Obsessive-Compulsive Disorder;optogenetics;Parkinson Disease;Participant;Pathway Analysis;Postdoctoral Fellow;posters;prevent;professor;programs;Prosencephalon;public health relevance;Research;Research Personnel;Schedule;Schizophrenia;Site;social;Societies;South America;Staging;Students;symposium;Synaptic plasticity;Testing;Time;tool;Transgenic Mice;Translating;Travel;two-photon;United States National Institutes of Health;Weather;Woman;Work,2014 Basal Ganglia Gordon Research Conference,87696,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,,1,15000,
8626119,R15,CA,1,N,02/07/2014,02/07/2014,01/31/2017,393,R15CA176600,SCHOOLS OF PUBLIC HEALTH,PA-12-006,1R15CA176600-01A1,NCI:475181\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,WASHINGTON,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,00,043990498,US,GEORGE WASHINGTON UNIVERSITY,DC,20052,PUBLIC HEALTH RELEVANCE: Low-income Medicaid beneficiaries are much more likely to smoke than the general population and the number of adult Medicaid beneficiaries is expected to surge. Understanding factors that lead to more effective tobacco cessation policies in Medicaid can contribute to the development of stronger state policies. These could improve health by reducing tobacco use in a high risk population and help contain health care costs.            ,9450816;,"KU, LEIGHTON;","HARTMAN, ANNE ",02/07/2014,01/31/2017,Academic Research Enhancement Awards;Adult;Affect;Area;Award;base;Behavior;beneficiary;Cardiovascular system;career;Caring;Case Study;Cause of Death;Cessation of life;Cigarette;Data;Databases;design;Development;Doctor of Philosophy;doctoral student;Effectiveness;Environment;experience;follow-up;Funding;General Population;Goals;graduate student;Grant;Health;Health Care Costs;Health Insurance;Health Services;high risk;Hospital Costs;Hospitalization;improved;Individual;informant;innovation;insight;Interview;Lead;Link;Low income;Malignant Neoplasms;Measures;Medicaid;member;Methods;Modeling;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Policies;Population;population survey;Process;programs;public health relevance;Public Health Schools;reduce tobacco use;Research;Research Personnel;Risk;Schools;Series;skills;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;smoking prevalence;statistics;Students;Taxes;Time;tobacco control;Tobacco Dependence;Tobacco use;Tobacco Use Cessation;trend;United States;United States National Institutes of Health;Universities;Variant;Washington;Withholding Treatment;Work,Medicaid Tobacco Cessation: State Policies and Effectiveness,176600,ZRG1,Special Emphasis Panel,,A1,1,475181,
8624876,R15,CA,1,N,02/04/2014,02/04/2014,01/31/2017,396,R15CA182889,SCHOOLS OF ARTS AND SCIENCES,PA-12-006,1R15CA182889-01,NCI:429874\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,BIOLOGY,08,041808262,US,OAKLAND UNIVERSITY,MI,483094401,PUBLIC HEALTH RELEVANCE:  Clinical analysis of patients with leukemia has shown increased endothelial cell activity suggesting a role of these cells in the pathogenesis of the disease. This proposal will elucidate how the inflammatory response of endothelial cell activation participates in leukemia progression and relapse. The long-term goals are to use findings to develop novel treatment strategies that aim to treat leukemia while preventing relapse.            ,9344930;,"MADLAMBAYAN, GERARD JAMES;","DUGLAS-TABOR, YVONNE ",02/04/2014,01/31/2017,"Adherence (attribute);Adjuvant Therapy;Affect;base;Biological Markers;Blast Cell;Blocking Antibodies;Blood;Blood Cells;Blood Vessels;Bone Marrow;cancer cell;cell behavior;Cell Communication;Cell physiology;Cells;chemotherapy;Clinical;Complex;Data;Development;Disease;Disease Progression;Disease remission;Elements;Endothelial Cells;Environment;Feedback;Figs - dietary;Foundations;Goals;Growth;Hematopoietic stem cells;Histone Deacetylase;Human;In Vitro;in vivo;Inflammatory Response;Investigation;Killings;Knowledge;Lead;leukemia;Leukemia, Myelocytic, Acute;leukemogenesis;Mediating;Mediator of activation protein;Methods;novel;Outcome;Pathogenesis;Pathway interactions;Patients;Play;prevent;Process;Proliferating;protective effect;public health relevance;Relapse;Reporting;Research;Residual Tumors;Resistance;response;Rest;Role;Sampling;Stem Cell Leukemia;Testing;treatment strategy;Vascular Endothelial Cell;Work",Endothelial Cell Activation Regulates AML Growth and Relapse,182889,ZRG1,Special Emphasis Panel,,,1,429874,
8687540,R15,DC,1,N,02/03/2014,02/03/2014,01/31/2017,173,R15DC013900,SCHOOLS OF ARTS AND SCIENCES,PA-12-006,1R15DC013900-01,NIDCD:444845\,Research Projects,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PULLMAN,UNITED STATES,NONE,05,041485301,US,WASHINGTON STATE UNIVERSITY,WA,99164,"PUBLIC HEALTH RELEVANCE: Loss of sensory cells in the inner ear is the cause of most cases of human deafness. This research aims to identify novel natural products that may prevent sensory cell loss due to certain types of toxins so that we may preserve hearing. We use zebrafish as a model system for this research because we can test hundreds of compounds quickly and efficiently, cutting down on the time to develop new drugs to prevent hearing loss.            ",6893126;,"COFFIN, ALLISON B;","FREEMAN, NANCY ",02/03/2014,01/31/2017,Acoustic Nerve;Adenosine;Aging;Aminoglycoside Antibiotics;aminoglycoside-induced ototoxicity;Aminoglycosides;Antibiotics;Attenuated;Auditory;auditory stimulus;base;Biological Factors;Biological Models;Brain;Caffeine;career;Cell Death;cell injury;Cells;Cellular biology;Cessation of life;Chemicals;chemotherapeutic agent;Clinic;Clinical;clinical application;Cytoprotection;Data;Deafness;Development;Dissection;dosage;drug development;drug discovery;Epithelial Cells;Exposure to;Genetic;genetic manipulation;Gentamicins;Goals;Hair Cells;Hearing;hearing impairment;Human;Image;in vivo;in vivo Model;Infection;inhibitor/antagonist;Knowledge;Labyrinth;lateral line;Lead;Learning;Libraries;Life;Marines;Mediating;Medicine;microbial;Modeling;Molecular;Neomycin;Neurons;Neuroprotective Agents;Noise;novel;novel therapeutics;ototoxicity;ototoxin;Parkinson Disease;Patients;Pharmaceutical Preparations;Plant alkaloid;Plants;Play;prevent;Prevention;Property;protective effect;public health relevance;Purinergic P1 Receptors;receptor;relating to nervous system;Research;Research Personnel;research study;response;Role;Ruthenium Ben;Safety;Schedule;screening;Seizures;Sensory;Sensory Hair;Series;Signal Transduction;socioeconomics;sound;Source;Students;Study models;System;systems research;Techniques;Testing;Therapeutic;Time;Toxin;Training;Translating;Work;Zebrafish,Characterizing the protective effects of caffeine and other natural products in a,13900,ZAT1,Special Emphasis Panel,,,1,444845,
8635044,R21,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R21AA021876,SCHOOLS OF MEDICINE,PA-11-261,1R21AA021876-01A1,NIAAA:229281\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHICAGO,UNITED STATES,PSYCHIATRY,07,098987217,US,UNIVERSITY OF ILLINOIS AT CHICAGO,IL,60612,"PUBLIC HEALTH RELEVANCE:  Ethanol exerts profound effects on the developing brain resulting in compromised cognitive and behavioral functions characteristic of fetal alcohol spectrum disorders (FASD). This proposal is extremely innovative as it investigates for the first time the modulation of a class of glycoproteins, chondroitin sulfate proteoglycans, by ethanol and their role in ethanol-induced inhibition of neuronal plasticity. These studies will introduce te field of glycobiology/sulfatase enzyme biology to FASD research and will identify novel ethanol targets toward which design new and appropriate interventions for FASD.            ",7923113;,"GUIZZETTI, MARINA;","REGUNATHAN, SOUNDAR ",02/05/2014,01/31/2016,Adopted;Affect;alcohol effect;alcohol exposure;Alcohols;Anabolism;Architecture;Arylsulfatase B;Astrocytes;Attenuated;Axon;base;Behavioral;Binding (Molecular Function);Biology;Brain;brain commissure;Brain region;brevican;Cells;cellular targeting;Characteristics;Chondroitin Sulfate A;Chondroitin Sulfate C;chondroitin sulfate glycosaminoglycan;Chondroitin Sulfate Proteoglycan;Chondroitin Sulfates;Coculture Techniques;Cognitive;Commissure;Core Protein;Corpus Callosum;Cues;Dendrites;design;Development;Enzymes;Ethanol;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Future;Galactose;Glycobiology;Glycoproteins;Glycosaminoglycan Degradation Pathway;Glycosaminoglycans;Hippocampus (Brain);Human;human CSPG3 protein;In Vitro;in vivo;innovation;Inorganic Sulfates;Intervention;Lead;Mediating;Messenger RNA;Modeling;mRNA Expression;Neonatal;Neonatal Alcohol Exposure;nervous system development;Neurites;Neuroglia;Neuronal Plasticity;Neurons;novel;polysulfated glycosaminoglycan;Pregnancy;premature;prevent;Process;Property;protein expression;Proteins;proteoglycan core protein;public health relevance;Rattus;Recombinants;Reporting;Research;Role;Signal Transduction;Sulfatases;Supplementation;Synapses;Testing;Third Pregnancy Trimester;Time;treatment effect;Unspecified or Sulfate Ion Sulfates;Up-Regulation (Physiology);Visual system structure,Effect of ethanol on chondroitin sulfate proteoglycans: relevance to FASD,21876,AA,Biomedical Research Review Subcommittee,,A1,1,229281,
8628378,R21,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R21AA021878,SCHOOLS OF ARTS AND SCIENCES,PA-11-018,1R21AA021878-01A1,NIAAA:225956\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,ALBUQUERQUE,UNITED STATES,PSYCHOLOGY,01,868853094,US,UNIVERSITY OF NEW MEXICO,NM,87131,"PUBLIC HEALTH RELEVANCE: College women report high rates of sexual victimization and revictimization. The goal of this study is to test a theoretical model of their risk for sexual assault. This model posits that difficulties making risk judgments and response choices to risky situations mediate the relationship between a history of sexual victimization and revictimization. It also posits that these difficulties will predict future victimization, regardless of whether womn report a previous victimization experience. We will examine whether aspects of women's alcohol use moderate the hypothesized meditational links in the model. College women will be followed prospectively for 6 months. At baseline, participants will complete tasks assessing their risk judgments and response choices to risky situations, as well as questionnaires assessing past victimization experiences and aspects of their alcohol use. They will again complete these tasks and questionnaires at follow-up. Testing this model is highly significant from a public health perspective, as this work will directly inform the content development for a preventive intervention for at-risk women that would target women's processing of risk-relevant information and their ability to provide risk-reducing responses to high risk situations.                ",10592563;,"YEATER, ELIZABETH;","FREEMAN, ROBERT ",02/05/2014,01/31/2016,Age;Aggressive behavior;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol expectancy;alcohol risk;Alcohols;Attitude;base;college;Complement;cost;Crime;Development;Disinhibition;Eating;Ethnicity aspects;experience;follow-up;Forcible intercourse;Future;General Population;Generations;Goals;high risk;information processing;innovation;Intervention;Judgment;Lead;Link;Mediating;men;Mental Health;Modeling;Mood Disorders;Participant;Pattern;perpetrators;physical conditioning;Post-Traumatic Stress Disorders;Pregnancy;Preventive Intervention;Process;Psychopathology;public health medicine (field);public health relevance;Questionnaires;Recording of previous events;Reporting;Research;response;revictimization;Risk;Risk Factors;risk perception;sexual assault;Sexually Transmitted Diseases;social;Solutions;Testing;Theoretical model;therapy development;trait;university student;Victimization;Woman;Work,"Risk Processing, Alcohol Use, and College Women's Sexual Victimization",21878,AA,Biomedical Research Review Subcommittee,,A1,1,225956,
8638593,R21,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R21AA022189,SCHOOLS OF MEDICINE,PA-11-261,1R21AA022189-01A1,NIAAA:215625\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,LOUISVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,057588857,US,UNIVERSITY OF LOUISVILLE RES FDN,KY,40292,PUBLIC HEALTH RELEVANCE: This project will determine the contributing role of dysregulated hepatocyte PDE4/cAMP homeostasis in the development of alcohol-induced hepatic steatosis and injury and examine the efficacy of PDE4 inhibition in the prevention and treatment of alcoholic liver disease.                ,11058066;,"GOBEJISHVILI, LEILA;","RADAEVA, SVETLANA ",02/05/2014,01/31/2016,Acute;ADD-1 protein;Adenylate Cyclase;Affect;alcohol effect;alcohol exposure;alcohol response;Alcoholic Liver Diseases;Alcohols;Anabolism;Animal Feed;Apoptosis;Apoptotic;base;Cause of Death;Cell physiology;Cessation of life;Chronic;chronic alcohol ingestion;Cirrhosis;Clinical Treatment;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic AMP-Responsive DNA-Binding Protein;cytokine;Data;Development;Endotoxins;Enzymes;Ethanol;Family;fatty acid oxidation;Fatty Acids;Fatty Liver;FDA approved;feeding;Fibrosis;Future;Genes;Glucocorticoids;Goals;Hepatic;Hepatocyte;Hepatorenal Syndrome;Hepatotoxicity;Homeostasis;Hydrolysis;In Vitro;in vivo;Individual;Inflammatory;inhibitor/antagonist;Injury;Injury to Liver;Intervention;intervention effect;Knock-out;Kupffer Cells;Label;lipid biosynthesis;lipid metabolism;Liver;Liver diseases;liver injury;macrophage;Metabolism;monocyte;Mortality Vital Statistics;Mus;oxidation;Patients;Pentoxifylline;Peroxisome Proliferator-Activated Receptors;Pharmacotherapy;Phosphodiesterase Inhibitors;phosphoric diester hydrolase;Phosphorylation;Play;Predisposition;Prevention;problem drinker;public health relevance;receptor;Regulation;response;Role;Rolipram;second messenger;Second Messenger Systems;Severities;Staging;Steroid Resistance;Steroid therapy;Stimulus;System;Therapeutic;TNF gene;Toxic effect;translational study;United States;Up-Regulation (Physiology);Work,The role of hepatocyte cAMP/PDE4 in alcohol-induced liver steatosis and injury,22189,AA,Biomedical Research Review Subcommittee,,A1,1,215625,
8636799,R21,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R21AA022202,,PA-11-018,1R21AA022202-01A1,NIAAA:193421\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BELTSVILLE,UNITED STATES,,05,021883350,US,PACIFIC INSTITUTE FOR RES AND EVALUATION,MD,207053111,"PUBLIC HEALTH RELEVANCE: An evaluation of the level of understanding recent immigrants may have about alcohol-related traffic laws and policies, and their level of compliance and an estimation of the prevalence of the problem will be crucial to assessing the need for designing efficient countermeasures. If such a need were proven, this study will help the design of future, more comprehensive research efforts.            ",6711159;8032428 (contact);,"DE LA ROSA, MARIO R.;ROMANO, EDUARDO O (contact);","GODETTE, DIONNE ",02/05/2014,01/31/2016,21 year old;Accounting;Acculturation;Address;Adoption;Age;Alcohol consumption;alcohol effect;Alcohol or Other Drugs use;Alcohols;Americas;Attitude;Automobile Driving;Awareness;base;Behavior;cohesion;Complex;Data;demographics;design;drinking;driving behavior;Driving While Intoxicated;drug driving;Drug Kinetics;Drug usage;Environment;Evaluation;Event;experience;Family;Female;Florida;Foundations;Future;Gender;Group Identifications;Heterogeneity;Illicit Drugs;Immigrant;impaired driving performance;In-Migration;Latino;Laws;Legal;Light;Longitudinal Studies;male;Motor Vehicles;One-Step dentin bonding system;Outcome Measure;Participant;Pharmaceutical Preparations;Play;Policies;Prevalence;Prevention program;public health relevance;Reporting;Research;Risk;risk perception;Risk-Taking;Role;Running;Seat Belts;Shapes;social capital;Socioeconomic Status;Speed (motion);stem;Stress;Subgroup;success;Surveys;Target Populations;trafficking;Translating,Drinking and Driving Among Recent Latino Immigrants,22202,ZAA1,Special Emphasis Panel,,A1,1,193421,
8634993,R21,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R21AA022203,SCHOOLS OF MEDICINE,PA-11-261,1R21AA022203-01A1,NIAAA:220343\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,DETROIT,UNITED STATES,PSYCHIATRY,13,001962224,US,WAYNE STATE UNIVERSITY,MI,48202,"PUBLIC HEALTH RELEVANCE: Despite four decades of research in fetal alcohol spectrum disorders (FASD), maternal alcohol consumption during pregnancy continues to be a major public health problem in the U.S. and worldwide. One important effect of fetal alcohol exposure is a marked increase in iron deficiency in infancy, which may mediate and/or exacerbate growth and neurobehavioral sequelae of prenatal alcohol exposure. Our hypothesis that fetal alcohol-related effects on the placenta may disrupt the accumulation of fetal iron stores suggests that alcohol exposure can lead to iron deficiency anemia in infancy even when the mother herself is iron sufficient. Findings from this research can provide critical information about the pathophysiology of FASD, which can, in turn, contribute to the implementation of previously not considered, novel maternal and newborn interventions that are targeted to the specific mechanisms that mediate these disorders. The NIAAA Strategic Plan for Research has identified uncovering target sites for ethanol's action including iron homeostasis on the embryogenic and fetal stages of life to begin the development of potential therapeutic or preventive interventions, as a key long- term public health goal.            ",9743059;1976848 (contact);,"CARTER, ROBERT COLIN;JACOBSON, SANDRA W. (contact);","HERELD, DALE ",02/05/2014,01/31/2016,Affect;Age;Alcohol consumption;alcohol consumption during pregnancy;alcohol exposure;Alcoholic beverage heavy drinker;Alcohols;Anemia;Animals;Behavioral;binge drinking;Biological Markers;body system;Carrier Proteins;Cognitive deficits;cohort;Cohort Studies;Congenital Abnormality;Data;Development;Diet;Disease;Drug usage;Ethanol;Exposure to;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetus;Functional disorder;Gene Expression;Gestational Age;Goals;Growth;Heavy Drinking;Homeostasis;Human;human subject;Incidence;infancy;Infant;innovation;Intervention;Iron;iron deficiency;Iron deficiency anemia;Knowledge;Lead;Life;Light;Link;Mediating;meetings;Mental Retardation;Modeling;Mothers;National Institute on Alcohol Abuse and Alcoholism;Nervous System Physiology;neurobehavioral;Newborn Infant;novel;Nutrient;offspring;Outcome;Pathologist;Pathology;Pattern;Physiology;Placenta;placental transfer;Population;Population Study;Positioning Attribute;Postpartum Period;Pregnancy;Pregnant Women;prenatal;Prevalence;Preventive Intervention;prospective;protein expression;public health medicine (field);public health relevance;Rattus;Recruitment Activity;Research;Research Infrastructure;Research Personnel;Sampling;Site;Smoking Status;Staging;Strategic Planning;Structure;Testing;Therapeutic Intervention;Time;Work,Mediating and Moderating Effects of Fetal Alcohol-Related Iron Deficiency in FASD,22203,AA,Biomedical Research Review Subcommittee,,A1,1,220343,
8693866,R21,AI,1,N,02/03/2014,02/05/2014,01/31/2015,855,R21AI105330,SCHOOLS OF MEDICINE,PA-11-261,1R21AI105330-01A1,NIAID:228825\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,121911077,US,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,NY,10016,"PUBLIC HEALTH RELEVANCE: With their absolute dependence on host ribosomes, viruses have evolved a diverse array of strategies to gain control of their host's protein synthesis machinery and thwart host defenses aimed at crippling the synthesis of viral proteins. In this proposal we aim to determine how the poorly understood process of localized translation occurs during poxvirus infection and its role in regulating both viral and host protein synthesis. While advancing our understanding of how these deadly agents that killed hundreds of millions exploit host functions to replicate, with the potential to develop novel therapeutics, these studies will also provide valuable insights into fundamental mechanisms of translational control of gene expression.            ",10933350;,"WALSH, DEREK;","CHALLBERG, MARK D.",02/05/2014,01/31/2016,7-methylguanosine triphosphate;Affect;Antiviral Response;base;Binding (Molecular Function);Biological;Biological Process;Cells;Complement;Complex;Controlled Study;Cytoplasm;Data;Dependence;Development;Dissection;DNA Viruses;Double Stranded DNA Virus;Economics;environmental change;Eukaryotic Initiation Factors;Event;Family;Foundations;Gene Expression;Gene Expression Regulation;Genetic Code;Genetic Translation;helicase;Host Defense;human FRAP1 protein;Hurricane;Immune response;In Vitro;Infection;inhibitor/antagonist;insight;Integration Host Factors;interest;Ireland;Killings;Label;Learning;member;Membrane;Messenger RNA;metaplastic cell transformation;Molecular;mRNA capping;mutant;Neuronal Plasticity;new therapeutic target;novel therapeutics;pathogen;Pathway interactions;Phosphorylation;Play;Poly A;Polyribosomes;Post-Transcriptional Regulation;Poxviridae;Poxviridae Infections;Process;Production;programs;Protein Binding;Protein Biosynthesis;Proteins;Proteus;public health relevance;Recovery;Regulation;Relative (related person);Repressor Proteins;Research;response;Ribosomes;Role;Scaffolding Protein;Scanning;Signal Transduction;Site;Staging;Structure;System;Testing;Therapeutic Studies;Time;translation factor;Translation Initiation;Translations;Vaccinia virus;Viral;Viral Proteins;Virus;Virus Diseases;Virus Replication,Translational control of gene expression during poxvirus infection,105330,VIRB,Virology - B Study Section,,A1,1,228825,
8702404,R21,AI,1,N,02/05/2014,02/05/2014,01/31/2015,855,R21AI105435,SCHOOLS OF MEDICINE,PA-11-261,1R21AI105435-01A1,NIAID:205200\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,068552207,US,WASHINGTON UNIVERSITY,MO,631304862,PUBLIC HEALTH RELEVANCE: Highly pathogenic H5N1 influenza virus causes severe disease and death in humans and represents a considerable threat to public health. This project will identify a host gene containing a genetic polymorphism that is associated with severe H5N1 disease. The discovery of host genes modulating influenza disease will provide much needed insight into H5N1 virus biology and uncover new treatment options for this deadly disease.            ,10879506;,"BOON, ADRIANUS CM;","HAUGUEL, TERESA M.",02/05/2014,01/31/2016,"A/J Mouse;Affect;Africa;Animals;Antiviral Agents;Asthma;base;Biological;Biology;burden of illness;C57BL/6 Mouse;Candidate Disease Gene;Cells;Cessation of life;Chromosomes;Chromosomes, Human, Pair 4;Congenic Mice;consomic;cytokine;Data;design;Diabetes Mellitus;Disease;Elderly;Epidemic;Epidemiology;experience;Far East;Future;gene function;Genes;Genetic;Genetic Determinism;Genetic Polymorphism;Human;Immune response;Immunologics;In Vitro;Inbred Strains Mice;Individual;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;Influenza B virus;influenzavirus;insight;Integration Host Factors;Kinetics;Lung;Measures;microbial;Mortality Vital Statistics;Mouse Strains;Mus;Mutation;novel;pandemic disease;pandemic influenza;pathogen;Pathogenesis;Pathology;Persons;Positioning Attribute;Predisposition;Process;Production;Property;public health medicine (field);public health relevance;receptor expression;Reporting;research study;Resistance;Respiratory System;Respiratory tract structure;RNA Interference;Role;Sendai virus;Severities;Severity of illness;sialic acid receptor;Single Nucleotide Polymorphism;Testing;Variant;Variation (Genetics);Viral;Viral load measurement;Viral Load result;Viral Pathogenesis;Virus Diseases;virus pathogenesis;Virus Replication;West Nile virus",IDENTIFICATION OF HOST GENETIC DETERMINANT CAUSING SEVERE INFLUENZA PATHOGENESIS,105435,VIRB,Virology - B Study Section,,A1,1,205200,
8681113,R21,AI,1,N,02/07/2014,02/07/2014,01/31/2015,855,R21AI106779,SCHOOLS OF VETERINARY MEDICINE,PA-11-261,1R21AI106779-01A1,NIAID:167288\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,FORT COLLINS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,04,785979618,US,COLORADO STATE UNIVERSITY,CO,80523,"PUBLIC HEALTH RELEVANCE: We have increasing evidence that a pool of [mostly] Beijing strains of M. tuberculosis isolated within the USA are highly resistant to the effects of BCG vaccination in small animal models, whereas isolates from the Western Cape of South Africa are strongly inhibited by the vaccine. This proposed study will test the hypothesis that the underlying mechanism for these events reflects the preferential ability of the US strains to potently induce regulatory T cells.                ",1902007;,"ORME, IAN M;","LACOURCIERE, KAREN A.",02/07/2014,01/31/2016,Adoptive Transfer;Animal Model;Area;arm;Asia;base;Cavia;Cell Separation;Cells;Clinical;cost;Data;Disease Outbreaks;Drug resistance;Event;Failure (biologic function);Family;Fingers;Gold;Immunity;Incidence;Infant;Knock-in Mouse;Laboratories;Learning;Lung;Modeling;mRNA Expression;Mus;Mycobacterium tuberculosis;novel vaccines;Paper;Pathology;Patients;Planets;programs;protective effect;public health medicine (field);public health relevance;Reading;Regulatory T-Lymphocyte;Resistance;resistant strain;San Francisco;Shame;Site;South Africa;Speed (motion);Study Section;T-Lymphocyte;Techniques;Testing;Tuberculosis;Tuberculosis Vaccines;vaccination against tuberculosis;vaccine evaluation;Vaccines;Virulence;Virulent;Visit;Work,BCG efficacy against W-Beijing TB strains,106779,VMD,Vaccines Against Microbial Diseases Study Section,,A1,1,167288,
8702472,R21,AI,1,N,02/06/2014,02/06/2014,01/31/2015,855,R21AI107447,SCHOOLS OF MEDICINE,PA-11-261,1R21AI107447-01A1,NIAID:194681\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RICHMOND,UNITED STATES,BIOCHEMISTRY,03,105300446,US,VIRGINIA COMMONWEALTH UNIVERSITY,VA,232980568,"PUBLIC HEALTH RELEVANCE:  A critical barrier to developing effective modulating agents for our immune response is our incomplete understanding of how protein interactions elicit key events downstream of innate immune sensors. This research seeks to characterize the function of a newly identified TBK1 substrate - Suppressor of IKK?, a downstream component of the innate immune response. These studies will explore a previously unrecognized connection between the innate immune response and cytosolic RNA granules providing a new paradigm for coordinating host defenses to stem pathogen invasion and a mechanistic model to examine viral subversion of this host defense mechanism.                ",6969254;,"BELL, JESSICA K;","LEITNER, WOLFGANG W.",02/06/2014,01/31/2016,"Actins;Address;Affinity;Antiviral Agents;base;Biological Assay;Carrier Proteins;Cell Line;cell motility;cell type;Cells;Cellular Stress;Cellular Structures;Chemicals;Complex;Cytoplasmic Granules;Cytoskeleton;Cytosol;Data;Defense Mechanisms;DNA Sequence Rearrangement;Double-Stranded RNA;Epithelial;Epithelial Cells;Event;Excision;Fluorescence Microscopy;Foundations;gamma Actin;Genetic Translation;Host Defense;Host Defense Mechanism;IKKepsilon;Image;Immune;Immune response;immune RNA;Immune system;Immunofluorescence Immunologic;Inflammatory Response;inhibitor/antagonist;innovation;insight;Invaded;Knock-out;Knowledge;Label;Lead;Life;Ligands;Link;Location;Longitudinal Studies;Lung;macrophage;Mediating;Messenger RNA;Microscopy;mimetics;Modeling;Myelogenous;Myeloid Cells;novel;pathogen;Pathway interactions;Pattern;Phagocytes;Phagocytosis;Phosphorylation;Phosphotransferases;Poly I-C;Post-Transcriptional Regulation;Process;protein function;Protein Isoforms;Proteins;public health relevance;Regulation;Research;Resolution;response;Ribonucleoproteins;RNA;RNA, Messenger, Stored;Role;Salmonella typhimurium;sensor;Serine;Shapes;Signal Pathway;Signal Transduction;small hairpin RNA;stem;Stimulus;Stress;stressor;Structure;TANK-binding kinase 1;trafficking;Translations;Vacuole;Viral;Virus Diseases",Functional Characterization of Suppressor of IKKepsilon,107447,III,Innate Immunity and Inflammation,,A1,1,194681,
8732199,R21,AI,1,N,02/03/2014,02/05/2014,01/31/2015,855,R21AI110214,,PA-11-261,1R21AI110214-01A1,NIAID:201844\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BETHESDA,UNITED STATES,,08,144676566,US,HENRY M. JACKSON FDN FOR THE ADV MIL/MED,MD,208171891,"PUBLIC HEALTH RELEVANCE: HIV infection is global pandemic that affects millions of people. The exploratory studies proposed in this application are highly relevant to public health for these reasons. First, they may help us better understand HIV pathogenesis in terms of the timing of different opportunistic infections during HIV infection. Second, they may lead to identification of a novel anti-HIV molecule in human primary CD4 T cells that holds potential for developing novel interventional strategies. Third, they may aid HIV vaccine design by providing new insights into identification of the protective, HIV vaccine-generated CD4 T cell immunity.            ",11761190;,"HU, HAITAO;","LI, YEN ",02/05/2014,01/31/2016,Acquired Immunodeficiency Syndrome;Address;Affect;ALVAC;Antigens;Antiviral Agents;Area;base;Biological Assay;Candida;Candida albicans;CD4 Positive T Lymphocytes;Cell Line;Cells;Chronic;Clinical;Clinical Research;cytokine;Cytomegalovirus;Data;Development;Differentiation Antigens;Exposure to;Figs - dietary;Gene Expression;Genes;genome-wide;HIV;HIV Infections;HIV vaccine;HIV-1;HIV/SIV vaccine;Homing;Human;Immunity;Immunization;In Vitro;in vitro Assay;Infection;insight;interest;Interleukin-17;Intervention;Knowledge;Label;Lead;Measures;Memory;memory CD4 T lymphocyte;Microarray Analysis;Molecular;novel;Opportunistic Infections;Outcome;pandemic disease;pathogen;Pathogenesis;Patients;Peripheral;Peripheral Blood Mononuclear Cell;permissiveness;Phenotype;Population;pre-clinical;Predisposition;Principal Investigator;programs;Proliferating;Proteins;public health medicine (field);public health relevance;Recombinants;Relative (related person);Reporting;research study;Resistance;Risk;Role;Sampling;sensor;Small Interfering RNA;Sorting - Cell Movement;Specificity;Surrogate Markers;System;T cell response;T-Lymphocyte;Testing;Tetanus Toxoid;Time;Vaccine Design;vaccine efficacy;Vaccines;vector;vector vaccine;vector-induced;Viral;viral RNA,Susceptibility of antigen-specific CD4 T cells to HIV: implications for HIV vacci,110214,VACC,HIV/AIDS Vaccines Study Study Section,,A1,1,201844,
8732072,R21,AI,1,N,02/03/2014,02/05/2014,01/31/2015,855,R21AI110220,SCHOOLS OF MEDICINE,PA-12-162,1R21AI110220-01A1,NIAID:202894\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,188435911,US,UNIVERSITY OF MARYLAND BALTIMORE,MD,212011508,"PUBLIC HEALTH RELEVANCE: Although HIV typically persists indefinitely within the body, even in the presence of uninterrupted long-term highly active antiretroviral therapy (HAART), how this persistence develops and is maintained remains a mystery and a significant public health concern. Bone marrow appears to be an important site for HIV persistence, but there is considerable controversy regarding the type(s) of cells infected and moreover, macrophages, which are resident cells in bone marrow and known to be hosts for HIV infection, have scarcely been investigated. This application will (1) quantitatively compare levels of HIV infection in macrophages and T-cells using bone marrow specimens from infected individuals on HAART, and (2) examine mechanisms of HIV persistence in bone marrow macrophages.                ",1870372;,"GARTNER, SUZANNE;","LAWRENCE, DIANE M",02/05/2014,01/31/2016,Acute;Address;AIDS/HIV problem;Anti-Retroviral Agents;Aspirate substance;Attention;base;Biological Assay;Biopsy Specimen;Blood;Bone Marrow;Brain;CCR5 gene;CD34 gene;CD4 Positive T Lymphocytes;Cell Cycle;Cell Lineage;cell type;Cells;Characteristics;Collection;Core Biopsy;Data;Detection;Development;DNA;Exhibits;Gagging;Generations;Health;Hematopoietic stem cells;Highly Active Antiretroviral Therapy;HIV;HIV Core Protein p24;HIV Genome;HIV Infections;HIV Protease;improved;In Vitro;in vivo;Individual;Infection;Investigation;Kinetics;Label;latent infection;Life;Longevity;macrophage;Marrow;Nature;novel;novel therapeutics;Nurses;Participant;Patients;Pharmaceutical Preparations;Population;Production;public health medicine (field);public health relevance;Publishing;Quality of life;Reporting;Research;Research Personnel;research study;Rest;RNA-Directed DNA Polymerase;self-renewal;Site;Specimen;Stem cells;Suggestion;T-Lymphocyte;Testing;Tissues;Viral;Viral Load result;Virus,HIV Infection in Bone Marrow: A Reservoir for Viral Persistence,110220,AIP,AIDS Immunology and Pathogenesis Study Section,,A1,1,202894,
8662416,R21,AI,1,N,02/06/2014,02/06/2014,01/31/2015,855,R21AI110712,SCHOOLS OF MEDICINE,PA-11-261,1R21AI110712-01,NIAID:161250\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,068552207,US,WASHINGTON UNIVERSITY,MO,631304862,"PUBLIC HEALTH RELEVANCE: Malaria is one of the world's devastating diseases: there are several hundred million cases worldwide and more than one thousand in this country, mostly imported from other countries. We have discovered a malaria parasite protein that responds to heme, a key metabolite for the organism when it is inside human red blood cells. Characterizing the function of this important protein has the potential to spur development of new antimalarial chemotherapy.            ",1930486;,"GOLDBERG, DANIEL E;","MCGUGAN, GLEN C",02/06/2014,01/31/2016,Aminolevulinic Acid;Antimalarials;Binding (Molecular Function);Cell Nucleus;Cells;chemotherapy;Chip seq;Chloroquine;Country;Development;Disease;DNA;DNA Binding;Dominant-Negative Mutation;Erythrocytes;Escherichia coli;Food;Gene Deletion;Gene Expression;Gene Targeting;Genes;Genetic Engineering;Goals;Growth and Development function;Heme;heme a;heme biosynthesis;Hemoglobin;Hemopexin;Homeostasis;Human;infancy;Knock-out;knockout gene;Knowledge;Malaria;mutant;new technology;Organism;Oxygenases;Parasites;Peptide Hydrolases;Peptides;Phenotype;Plasmodium falciparum;Play;porphyrin a;Porphyrins;Production;Protease Inhibitor;Protein Binding;Protein Biosynthesis;Proteins;protoporphyrin IX;public health relevance;Reporter;research study;response;Ribosomal RNA;Role;Signal Transduction;Source;Supplementation;System;Testing;Time;Transfer RNA;Vacuole;Viral,ROLE OF PFHO-1 IN P. FALCIPARUM INTRAERYTHROCYTIC DEVELOPMENT,110712,ZRG1,Special Emphasis Panel,,,1,161250,
8683643,R21,AI,1,N,02/07/2014,02/07/2014,01/31/2015,855,R21AI111103,SCHOOLS OF MEDICINE,PA-11-261,1R21AI111103-01,NIAID:227700\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DETROIT,UNITED STATES,BIOCHEMISTRY,13,001962224,US,WAYNE STATE UNIVERSITY,MI,48202,"PUBLIC HEALTH RELEVANCE: Bacterial vaginosis (BV) affects 29% of women in the US of reproductive age, 21 million, and its complications drain tens of billions of dollars annually from the US health care system, deriving from adverse reproductive health outcomes (8, 9), increased risk of acquisition of HIV-1 (10-15), and other sexually transmitted infections (16-18). The etiology of BV remains unknown, hence cure rates remain unsatisfactory and recurrence rates are 30-68% (19-21). Cost-effective diagnosis and prognosis of bacterial vaginosis, working towards an effective POC and home-care device, is needed. Traditional and pipeline tools are not adequate for diagnosis and are entirely non-prognostic. The novel, qPCR-based approach proposed for validation here, Lactobacillus Relative Composition (LbRC), is able to recognize patients whose therapy was incomplete, potentially distinguishing it from all competing assays, and has facilitated our discovery of a later event we define as conversion. Conversion is a global change in vaginal microbiota that occurs well before symptomatic BV. LbRC offers the much needed possibility of individualized alternative therapies when standard of care is not adequate, or later, at pre-BV conversion events, to allow for intervention before symptoms of BV recur. LbRC uses a superior strategy relative to competing assays, costs <$0.20 in materials per assay, uses equipment standard to clinical microbiology labs, and runs >40 batched assays at a time, commensurate with hospital throughput, and is a powerful tool for discovery of species involved in causing conversion.            ",1917904;,"AKINS, ROBERT A;","ROGERS, ELIZABETH ",02/07/2014,01/31/2016,21 year old;Acute;Address;Aerobic;Affect;Aftercare;Age;Alternative Therapies;alternative treatment;Anaerobic Bacteria;Back;Bacteria;Bacterial Vaginosis;base;Behavior Therapy;Biological Assay;Clinical;Clinical Microbiology;cost;cost effective;Cytolysins;Data;Detection;Development;Devices;Diagnosis;Diagnostic;Differential Diagnosis;Equipment;Etiology;Event;Future;Global Change;Healthcare Systems;HIV-1;Hospitals;improved;Incidence;Infection;inhibitor/antagonist;innovation;Intervention;Laboratories;Lactobacillus;Literature;Measures;microbiome;novel;novel diagnostics;novel strategies;Outcome;outcome forecast;patient home care;Patients;perforin;Population;prevent;prognostic;public health relevance;Qualifying;Race;Reaction;Recurrence;Relative (related person);Reporting;reproductive;Reproductive Health;Research;Risk;rRNA Genes;Running;Sampling;Sensitivity and Specificity;Sexually Transmitted Diseases;Side;standard of care;Subgroup;Symptoms;Testing;Time;tool;Treatment Efficacy;Vagina;Vaginitis;Validation;Woman;Work,"Validation of a novel diagnostic, prognostic assay for bacterial vaginosis",111103,ZRG1,Special Emphasis Panel,,,1,227700,
8683865,R21,AI,1,N,02/04/2014,02/05/2014,01/31/2015,855,R21AI111145,EARTH SCIENCES/RESOURCES,PA-11-261,1R21AI111145-01,NIAID:194400\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOZEMAN,UNITED STATES,VETERINARY SCIENCES,00,625447982,US,MONTANA STATE UNIVERSITY - BOZEMAN,MT,59717,"PUBLIC HEALTH RELEVANCE: Bacterial vaginosis (BV) is the most common vaginal disorder among reproductive age women and is associated with increased risks of acquiring sexually transmitted diseases, infertility, gestational abortion, pre-term birth, and perinatal mortality. A hallmark of BV is increased vaginal pH and a dysbiotic microbiota. This project will fill knowledge gaps in the mechanism underlying onset and progression of BV by i) determining the abundance and breadth of unique amino-acid decarboxylation pathways in the vaginal tract and identifying the microbial species encoding them and ii) determining the ability of these pathways to mitigate vaginal acidity and the regulatory mechanisms governing their activity using in vitro culture assays.                    ",9285898;11409446 (contact);,"WALK, SETH T;YEOMAN, CARL J. (contact);","DAVID, HAGIT S.",02/05/2014,01/31/2016,abortion;Accounting;Acidity;Acids;Address;Age;Amino Acids;antiporter;Arginine;arginyllysine;Bacteria;Bacterial Vaginosis;base;Biological Assay;Cadaverine;Carboxy-Lyases;cell growth;Cells;clinically relevant;Data;Decarboxylation;Development;Disease;Escherichia coli;Exhibits;extracellular;Funding;Genes;HIV;In Vitro;Infertility;Inflammatory;Inflammatory Response;Investigation;Knowledge;Lead;Link;Low Birth Weight Infant;Lysine;Mediating;member;microbial;Mobiluncus;Mortality Vital Statistics;Mothers;neonate;novel therapeutics;Odors;Ornithine;Orthologous Gene;pathogen;Pathway interactions;Patients;Pelvic Inflammatory Disease;Pelvis;Perinatal mortality demographics;Phase;Phenotype;Polyamines;Pregnant Women;Prevotella;Production;Protons;public health relevance;Publishing;Pump;Putrescine;reproductive;Resistance;Risk;Sampling;Sexually Transmitted Diseases;Smell Perception;Streptococcus;Symptoms;Taxon;Term Birth;Third Pregnancy Trimester;Vagina;Vaginal Diseases;Variant;Walking;Woman;Work,Microbial Polyamine-Mediated Reductions in Vaginal Acidity;A Mechanistic Underst,111145,ZRG1,Special Emphasis Panel,,,1,194400,
8683890,R21,AI,1,N,02/03/2014,02/05/2014,01/31/2015,855,R21AI111175,EARTH SCIENCES/RESOURCES,PA-11-261,1R21AI111175-01,NIAID:201825\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,UNIVERSITY PARK,UNITED STATES,ZOOLOGY,05,003403953,US,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,PA,16802,"PUBLIC HEALTH RELEVANCE: Human malaria, transmitted by Anopheles mosquitoes, is the most important vector- borne disease in the world. Genetic manipulation of Anopheles mosquitoes is a critical part of research in this important vector genus, but techniques for genetic manipulation are very difficult and inefficient. In this research we will develop a novel, easy and efficient technique, called ReMOT Control, for genetic manipulation of Anopheles mosquitoes.                ",8241865;,"RASGON, JASON L;","COSTERO, ADRIANA ",02/05/2014,01/31/2016,Address;Adult;Anopheles Genus;arthropod genetics;Arthropod Vectors;Arthropods;Culicidae;DNA;DNA Binding Domain;DNA Transposable Elements;Drosophila melanogaster;Egg Yolk Proteins;Embryo;endonuclease;Engineering;enhanced green fluorescent protein;Entomology;Enzymes;Female;flexibility;Fluorescence;FUS-1 Protein;gain of function;Gene Deletion;Gene Transfer Techniques;Genes;Genetic;genetic manipulation;Human;Injection of therapeutic agent;Insecta;interest;knockout gene;Malaria;Mediating;Medical;Methods;Microinjections;Molecular;Mosquito Control;novel;nuclease;offspring;Oocytes;Oogenesis;Ovary;Protein Precursors;Proteins;public health relevance;receptor;receptor mediated endocytosis;Research;Research Personnel;research study;restriction enzyme;Site;Southern Blotting;Taxon;Techniques;Transcription Coactivator;Transgenic Organisms;Transposase;vector;Vector-transmitted infectious disease;Western Blotting,ReMOT Control of mosquito transgenesis,111175,VB,Vector Biology Study Section,,,1,201825,
8731597,R21,AI,1,N,02/06/2014,02/06/2014,01/31/2015,855,R21AI112417,SCHOOLS OF MEDICINE,PA-11-261,1R21AI112417-01,NIAID:169063\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLUMBIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,09,153890272,US,UNIVERSITY OF MISSOURI-COLUMBIA,MO,65211,PUBLIC HEALTH RELEVANCE: The HIV capsid (CA) protein plays an important role in HIV infection and has so far been an untapped target for HIV inhibitors. This project will evaluate the unique mechanism of action of a series of newly identified inhibitors targeting HIV CA. These studies will provide important insights into the design of new inhibitors of HIV that could complement existing treatments.                ,8742873;,"SARAFIANOS, STEFAN;","GUPTA, KAILASH C.",02/06/2014,01/31/2016,Affect;Anti-Retroviral Agents;Antiviral Agents;base;Binding (Molecular Function);Biological;Biological Assay;C-terminal;Capsid;Capsid Proteins;Cell Culture Techniques;Cell Line;Cells;Clinic;Clinical;Complement;Complex;crosslink;Cysteine;cytotoxic;cytotoxicity;Data;design;DNA;drug discovery;Drug resistance;Engineering;Event;Future;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV-1;Housing;Individual;Infection;inhibitor/antagonist;insight;Integration Host Factors;knock-down;Laboratories;Lead;Length;Life Cycle Stages;Link;macrophage;monocyte;Morbidity - disease rate;Morphology;Mortality Vital Statistics;Multi-Drug Resistance;Mutation;novel;Nuclear;Patients;Peripheral Blood Lymphocyte;Pharmaceutical Preparations;Play;Polyadenylation;Process;public health relevance;Relative (related person);research study;Resistance;Reverse Transcription;Role;screening;Series;Site;small molecule;small molecule libraries;Staging;Structure;Testing;Therapeutic;Time;Transmission Electron Microscopy;Tube;Vial device;Viral;viral DNA;Viral Drug Resistance;Viral Load result;Viral Proteins;Virus,Capsid-Targeting Small Molecules Blocking HIV through Novel Mechanism of Action,112417,ADDT,AIDS Discovery and Development of Therapeutics Study Section,,,1,169063,
8619768,R21,CA,1,N,12/03/2013,12/03/2013,11/30/2014,394,R21CA181830,SCHOOLS OF MEDICINE,PAR-12-145,1R21CA181830-01,NCI:166931\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,BIOCHEMISTRY,07,188435911,US,UNIVERSITY OF MARYLAND BALTIMORE,MD,212011508,"PUBLIC HEALTH RELEVANCE: Breast cancer is the second most common cause of cancer-related death in women, yet there are no established biomarker assays for early detection of breast cancer. We propose to develop a highly sensitive serum detection bioassay for breast cancer antigens based on the exquisite affinity and selectivity of lamprey antibodies for cancer-associated glycans, which can enable prediction of breast cancer risk, diagnosis and staging, prognosis and monitoring the response to therapy.            ",9636945;,"PANCER, ZEEV;","WANG, WENDY ",12/03/2013,11/30/2015,Affinity;Antibodies;Antigens;base;Binding (Molecular Function);Biological Assay;Biological Markers;Blood;Body Fluids;Breast Cancer Cell;Breast Cancer Detection;Breast Cancer Early Detection;cancer cell;Cancer cell line;Cancer Detection;cancer diagnosis;Cancer Diagnostics;Cancer Etiology;cancer risk;cancer type;Cell Surface Proteins;Cessation of life;Clinical;combinatorial;Conditioned Culture Media;Data;Detection;Diagnosis;Diagnostic;Diagnostic tests;Disease;Disease remission;Distant;Drops;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;Evaluation;Foundations;Glycoproteins;glycosylation;Goals;Human;Intervention;Lampreys;Lectin;Leucine-Rich Repeat;Libraries;malignant breast neoplasm;Malignant Neoplasms;Membrane Glycoproteins;Monitor;neoplastic cell;Normal Cell;novel;Organ;outcome forecast;Patients;Pattern;Performance;Petromyzon marinus;Polysaccharides;prognostic;Prognostic Marker;Prospective Studies;public health relevance;Reagent;Research Design;response;Sampling;Screening for cancer;Sensitivity and Specificity;Serum;Specificity;Staging;Structure;Surface;Survival Rate;Testing;Therapeutic;tumor;tumorigenesis;United States;Woman;Yeasts,Early detection of breast cancer serum antigens with lambodies,181830,ZCA1,Special Emphasis Panel,,,1,166931,
8684219,R21,CA,1,N,02/05/2014,02/05/2014,01/31/2015,396,R21CA184612,,PAR-12-096,1R21CA184612-01,NCI:183244\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,TAMPA,UNITED STATES,,15,139301956,US,H. LEE MOFFITT CANCER CTR &RES INST,FL,336129497,"PUBLIC HEALTH RELEVANCE: According to the World Health Organization (WHO), the incidence of melanoma is increasing faster than any other cancer. Currently, the median survival for metastatic melanoma is still in the realm of 12-14 months and there are few therapies that offer a significant improvement in overall survival. Special effort has been given t understanding the regulation of this cancer at the molecular level in order to identify new therapeutic targets. Among them, epigenetic changes, defined as modifications affecting gene expression without altering the DNA sequence, are capturing special attention due to their pivotal role in the pathogenesis of cancer and their potential modulation through pharmacological intervention. In this context, a family of drugs collectively known as histone deacetylase inhibitors (HDACi) regulates the packaging of DNA and interferes with other cellular functions, diminishing the proliferation of melanoma and enhancing recognition and clearance by the immune system. However, the non-specific action of these drugs encourages the development of more selective drugs which would target single master targets involved in the pathogenesis of cancer. In this application we propose to study HDAC6 as a potential target for modulating pathways related to the immunogenicity and proliferation of melanoma.            ",9699594;,"VILLAGRA, ALEJANDRO V;","WALI, ANIL ",02/05/2014,01/31/2016,Address;Adverse effects;Affect;Apoptosis;Attention;Blocking Antibodies;BRAF gene;Cell Cycle;Cell Cycle Regulation;Cell physiology;Cellular Immunology;Characteristics;Chromatin;contextual factors;Data;Deacetylase;Deacetylation;Development;DNA Packaging;DNA Sequence;Drug effect disorder;Environment;Epigenetic Process;Family;Gene Expression;Genetic;HDAC6 gene;Hematologic Neoplasms;Histone Deacetylase Inhibitor;Histones;Immune;Immune response;Immune system;Immunobiology;immunogenicity;immunoregulation;improved;In Vitro;in vivo;in vivo Model;Incidence;inhibitor/antagonist;Integration Host Factors;interest;Interleukin-10;Interleukin-6;Intervention;leukemia/lymphoma;malignant breast neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;melanoma;Melanoma Cell;member;Metastatic Melanoma;Modification;Molecular;new therapeutic target;Outcome;overexpression;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Positioning Attribute;prevent;Process;Property;Proteins;public health relevance;Regulation;Regulatory Pathway;Reporting;Role;Sampling;Solid Neoplasm;STAT1 gene;STAT3 gene;Testing;Therapeutic;therapeutic target;tumor;Tumor Antigens;Tumor Escape;tumor progression;Vorinostat;World Health Organization,Role of HDAC6 in the modulation of Immune-related pathways in Melanoma,184612,ZRG1,Special Emphasis Panel,,,1,183244,
8636379,R21,EY,1,N,02/01/2014,02/01/2014,01/31/2015,867,R21EY023364,GRADUATE SCHOOLS,PA-11-261,1R21EY023364-01A1,NEI:145000\,Research Projects,2014,NATIONAL EYE INSTITUTE,,FORT WORTH,UNITED STATES,ANATOMY/CELL BIOLOGY,12,110091808,US,UNIVERSITY OF NORTH TEXAS HLTH SCI CTR,TX,761072699,"PUBLIC HEALTH RELEVANCE: Studies with cells isolated from the eye have provided a better understanding of how the eye works and discoveries on what happens during eye diseases. Research in this grant will generate new mouse eye cells to better understand what happens in glaucoma, a leading cause of vision loss and blindness. These cells will have unique properties that allow them to be immortal when grown at lower temperatures, but these cells will also retain their normal characteristics when grown at higher temperatures.             ",8684622;,"CLARK, ABBOT FREDERICK;","CHIN, HEMIN R",02/01/2014,01/31/2016,Address;Adult;Affect;Anatomy;Anterior;anterior chamber;Anterior eyeball segment structure;Aqueous Humor;Biology;Blindness;Cell Count;Cell Culture Techniques;Cell Line;cell type;Cells;Cellular biology;Characteristics;cold temperature;collecting tubule structure;Data;Disease;Eye;Eye diseases;Genetic Engineering;Glaucoma;Goals;Grant;High temperature of physical object;immortalized cell;Individual;innovation;Interferons;Large T Antigen;Learning;magnetic field;Magnetism;Major Histocompatibility Complex;Methods;Microspheres;Molecular;Molecular Biology;Morphology;mouse model;Mouse Strains;Mus;Muscle Fibers;Neonatal;Neurosciences Research;novel;novel therapeutics;Optic Nerve;Pathogenesis;Pathway interactions;Phenotype;Photoreceptors;Physiologic Intraocular Pressure;Population;Primary Cell Cultures;Primates;Proliferating;Promotor (Genetics);Property;public health relevance;Publications;Rattus;Research;Research Personnel;research study;Resistance;Resources;Retina;Retinal;Retinal Ganglion Cells;Rodent;Site;Structure of sinus venosus of sclera;Temperature;Testing;Therapeutic Agents;Tissues;tool;Trabecular meshwork structure;Vision;Visual impairment;Work,Conditionally immortalized TM cell and RGC lines from Animal Model,23364,BVS,,,A1,1,145000,
8617528,R21,HD,1,N,02/04/2014,02/04/2014,01/31/2015,865,R21HD078862,SCHOOLS OF MEDICINE,PA-11-261,1R21HD078862-01,NICHD:199650\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,ANN ARBOR,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,073133571,US,UNIVERSITY OF MICHIGAN,MI,481091274,"PUBLIC HEALTH RELEVANCE: The proposed studies are relevant to public health because they are expected to reveal a role for a gene inactivation mechanism in the pathogenesis of a number of inherited diseases in man. Knowledge gained may lead to the design of new drugs to treat these diseases and this, in turn, is expected to reduce discomfort and morbidity associated with these diseases. Thus, proposed studies are relevant to the part of the NIH mission that aims to extend healthy life and reduce the burdens of illness and disability.                ",2796608;,"KING, PHILIP D;","COULOMBE, JAMES N",02/04/2014,01/31/2016,Address;Affect;Alleles;Arteriovenous malformation;base;Behavior;Blood;Blood capillaries;Blood Vessels;burden of illness;capillary;cell type;Cells;design;Development;disability;Disease;Dominant-Negative Mutation;driving force;Etiology;functional loss;Gene Expression Profiling;Gene Silencing;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Goals;Health;Hereditary Disease;Human;Human Development;human disease;Inheritance Patterns;Inherited;innovation;Knowledge;Laboratories;Lead;Lesion;Life;loss of function;malformation;Mammalian Cell;man;Mission;Morbidity - disease rate;Mutate;Mutation;Nature;Normal Cell;novel;Outcome;Pathogenesis;Patients;Pharmaceutical Preparations;Phenotype;Proteins;public health medicine (field);public health relevance;ras GTPase-Activating Proteins;Reporting;Role;Signal Transduction;Testing;United States National Institutes of Health;Vascular Diseases;Vascular Endothelial Cell;Work,Random Monoallelic Expression and Human Disease,78862,GHD,Genetics of Health and Disease Study Section,,,1,199650,
8638307,R21,MH,1,N,02/06/2014,02/06/2014,01/31/2015,242,R21MH099508,,PA-11-261,1R21MH099508-01A1,NIMH:214776\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,10032,"PUBLIC HEALTH RELEVANCE: The development of new treatments for schizophrenia (SCZ), a psychiatric condition that is prevalent and highly disabling despite antipsychotic medications, has been limited by the lack of a clear understanding of the effects of new treatments on the brain. In this project we will use Magnetic Resonance Spectroscopy (MRS) and N-acetylcysteine challenge to develop an imaging method that will help researchers understand the effects of glutamatergic medications on the brain in SCZ. The successful completion of this work has the potential to help streamline the process of developing and evaluating novel treatments for this severe and  debilitating illness, and as such has significant public health implications.                      ",10308165;1910148 (contact);,"GIRGIS, RAGY RAMSIS;KEGELES, LAWRENCE S (contact);","HILLEFORS, MI ",02/06/2014,01/31/2016,Academia;Acetylcysteine;Address;Adverse effects;Amino Acids;Antioxidants;antiporter;Antipsychotic Agents;base;Basic Science;Biological Markers;Brain;Brain imaging;Chronic;Clinical;Clinical Data;clinical effect;clinical efficacy;Clinical Trials;Cognitive;Cognitive deficits;Cysteine;Cystine;Data;design;Development;disability burden;Dopamine Receptor;Dose;drug development;Effectiveness;Exhibits;extracellular;Functional disorder;Future;Genetic;Glutamate Receptor;Glutamatergic Agents;Glutamates;Glutathione;Government;Image;imaging modality;Impairment;improved;in vivo;indexing;Individual;Lead;Magnetic Resonance Spectroscopy;Measurement;Measures;Medial;Metabolic;Metabolism;Methods;N-Methylaspartate;Neurobehavioral Manifestations;neurochemistry;novel;Outcome Measure;Oxidation-Reduction;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacological Treatment;pre-clinical;preclinical study;Prefrontal Cortex;Process;public health medicine (field);public health relevance;Recruitment Activity;Reporting;Research Personnel;Role;Schizophrenia;Signal Transduction;Site;Symptoms;Synapses;System;theories;Therapeutic Agents;therapeutic development;therapy development;tool;Translating;treatment effect;Work,Neurochemical and Clinical Effects of Glutamate Modulation in Schizophrenia,99508,PMDA,Pathophysiological Basis of Mental Disorders and Addictions Study Section,,A1,1,214776,
8620463,R21,MH,1,N,02/07/2014,02/07/2014,01/31/2015,242,R21MH102544,SCHOOLS OF SOCIAL WELFARE/WORK,PAR-13-054,1R21MH102544-01,NIMH:235578\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,BALTIMORE,UNITED STATES,NONE,07,188435911,US,UNIVERSITY OF MARYLAND BALTIMORE,MD,212011508,"PUBLIC HEALTH RELEVANCE: Children with disruptive behavior difficulties reared by families involved in the child welfare (CW) system have an increased risk of future maltreatment and out-of-home placement, yet have difficulty accessing and engaging with child mental health providers. The proposed R21 study will refine task-shifting strategies to implement an Evidence-Based Practice (EBP), originally provided by advanced mental health practitioners (Masters or PhDs) to reduce child disruptive behavior difficulties, so that it can be delivered by bachelors'-level caseworkers in Community Based Organizations (CBOs) providing placement prevention services to CW- involved families. In doing so, the proposed study will develop a strategy to increase access to needed mental health treatment for vulnerable families, thereby further reducing the risk for future maltreatment and out-of- home placement.            ",9011421;,"GOPALAN, GEETHA;","CHAMBERS, DAVID A",02/07/2014,01/31/2016,Address;Adoption;authority;base;Behavior;Caregivers;Child;Child Behavior;Child Mental Health;Child Welfare;Communities;Contracts;cost;design;Disruptive Behavior Disorder;Doctor of Philosophy;Effectiveness;Ensure;Evaluation Studies;Evidence based intervention;Evidence based practice;Family;Family Process;Future;Goals;Guidelines;Health Personnel;Health Professional;health training;Home environment;Hybrids;implementation science;implementation trial;improved;innovation;Intervention;Investigation;Knowledge;Location;Low income;maltreatment;meetings;Mental Health;Mental Health Services;Minority;Modeling;Monitor;Motivation;National Institute of Mental Health (U.S.);Policies;prevent;prevention service;Preventive;Problem behavior;Protocols documentation;Provider;psychosocial;public health medicine (field);public health relevance;Qualitative Methods;Research;Research Support;Resources;Risk;scale up;Services;Solutions;Specialist;Supervision;System;Testing;tool;Training;United States National Institutes of Health;Vulnerable Populations;Youth,Improving Child Behavior Using Task Shifting to Implement MFGs in Child Welfare,102544,DIRH,Dissemination and Implementation Research in Health Study Section,,,1,235578,
8714646,R21,NS,1,N,02/05/2014,02/01/2014,01/31/2015,853,R21NS084382,SCHOOLS OF MEDICINE,PA-11-261,1R21NS084382-01A1,NINDS:237000\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,NEUROLOGY,01,005421136,US,UNIVERSITY OF CHICAGO,IL,60637,PUBLIC HEALTH RELEVANCE: The goal of this proposal is to address the considerable demand for new imaging approaches for multiple sclerosis (MS) patients that will better reveal the underlying pathology responsible for clinical symptoms. In MS patients demyelination exposes axonal potassium (K+) channels that are normally shielded by the myelin sheath. We propose to develop imaging probes that will detect these channels and thereby provide a direct read-out of the clinically relevant neuropathology.                ,1862578;,"POPKO, BRIAN J;","UTZ, URSULA ",02/01/2014,01/31/2016,4-Aminopyridine;Address;Affinity;analog;Animal Model;Animals;Area;Autoradiography;Axon;base;Binding (Molecular Function);Biological;Biological Assay;Brain;Clinic;Clinical;clinically relevant;Complement;Data;Demyelinations;design;Development;Diagnosis;Evaluation;Event;Fluorine;Goals;Image;imaging probe;in vivo;Investigation;Label;Length;Lesion;Magnetic Resonance Imaging;Metabolic;Methods;Monitor;mouse model;Multiple Sclerosis;Myelin Sheath;Nerve;Nervous System Physiology;neuropathology;Pathologic;Pathology;Patients;Permeability;Pharmaceutical Preparations;Positron-Emission Tomography;Potassium;Potassium Channel;Property;Proteins;public health relevance;Radiolabeled;radiotracer;Reading;Relative (related person);research clinical testing;Resolution;Signal Transduction;Symptoms;Testing;Therapeutic;Tracer;uptake;voltage clamp;white matter,Fluorinated 4-Aminopyridines for Therapy and Diagnosis of Multiple Sclerosis,84382,CMBG,Cellular and Molecular Biology of Glia Study Section,,A1,1,237000,
8550512,R25,AA,1,N,02/04/2014,02/05/2014,01/31/2015,273,R25AA021363,SCHOOLS OF MEDICINE,PAR-11-205,1R25AA021363-01A1,NIAAA:237333\,Other Research Related,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,PSYCHIATRY,06,183710748,US,MEDICAL UNIVERSITY OF SOUTH CAROLINA,SC,29425,"PUBLIC HEALTH RELEVANCE: Heavy alcohol use and alcohol use disorders in psychiatric patients are associated with poor psychiatric outcomes, including suicide, and interfere with psychiatric treatments. This program will provide the first online evidence-based alcohol education curriculum for psychiatry residents that can be integrated into psychiatric training programs. The web-based modules developed in this project will increase psychiatrists'knowledge and skills at identifying and treating heavy drinking psychiatric patients. This in turn will further help people who drink too much.                ",7373621;,"BOOK, SARAH W;","ROACH, DEIDRA ",02/05/2014,01/31/2016,addiction;Address;Adopted;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol intervention;alcohol related problem;alcohol screening;alcohol use disorder;Alcohols;Anxiety Disorders;Attitude;base;Behavioral;Biological;brief intervention;Clinical Skills;Depression and Suicide;design;Development;drinking;Educational aspects;Educational Curriculum;Educational Grants;Educational process of instructing;Evaluation;evidence base;Exposure to;General Practices;Healthcare;Heavy Drinking;improved;Individual;Interview;Knowledge;medical specialties;Mental disorders;Mental Health;Methods;motivational enhancement therapy;Online Systems;Outcome;Patients;Pharmacological Treatment;Population;Pre-Post Tests;Prevalence;programs;Psychiatric therapeutic procedure;Psychiatrist;Psychiatry;public health medicine (field);public health relevance;Quality of life;Relative (related person);Residencies;Schizophrenia;screening;skills;suicidal risk;Suicide;Symptoms;Testing;Training;Training Programs;Treatment outcome;Video Recording,Development and Evaluation of a Web-Based Psychiatry Resident Alcohol Curriculum,21363,AA,Biomedical Research Review Subcommittee,,A1,1,237333,
8636840,R34,MH,1,N,02/03/2014,02/03/2014,01/31/2015,242,R34MH100253,SCHOOLS OF MEDICINE,PAR-12-071,1R34MH100253-01A1,NIMH:229121\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PEDIATRICS,14,004514360,US,UNIVERSITY OF PITTSBURGH,PA,15213,"PUBLIC HEALTH RELEVANCE:  This collaborative, two-site study will develop and pilot the feasibility and efficacy of a eleven session behavioral parent training program for feeding problems in children with autism compared to a wait list group. Children between the ages of 2 and 7 years diagnosed with an autism spectrum disorder who also have feeding problems will be recruited for this 5 month study.            ",1960284;,"JOHNSON, CYNTHIA R;","GILOTTY, LISA ",02/03/2014,01/31/2017,Achievement;Address;Adherence (attribute);Aftercare;Age;autism spectrum disorder;Autistic Disorder;base;Behavior;Behavior Therapy;Behavioral;Bite;Caregivers;Child;Child health care;Child Nutrition;Childhood;Control Groups;cost effective;Data;Data Collection;data management;Day Care;design;Development;Diagnosis;Diet;Diet and Nutrition;Diet Monitoring;Eating;efficacy testing;Enrollment;Epidemiology;Equipment and supply inventories;Evaluation;Exhibits;experience;Family;feeding;flexibility;Food;Food Aversion;Future;Goals;Health Services Research;Home environment;indexing;innovation;Inpatients;Intervention;Intervention Studies;Literature;Measurement;Measures;Mental disorders;Modeling;Monitor;NIH Program Announcements;non-compliance;nutrition;Nutritional;Nutritional status;Outcome;Outpatients;Parent-Child Relations;parental involvement;Parenting behavior;Parents;Participant;Pilot Projects;Population;Prevalence;primary outcome;Problem behavior;Procedures;programs;Protocols documentation;Psychopharmacology;psychosocial;public health relevance;Questionnaires;Randomized;Randomized Clinical Trials;Records;Recruitment Activity;Reporting;Research;Research Personnel;response;Ritual compulsion;Sampling;Schedule;Schools;Sensory;Services;Shapes;Site;Stress;success;Testing;Time;tool;Training;Training Programs;treatment center;treatment duration;Treatment Efficacy;Universities;Waiting Lists,1/2 Treatment of Feeding Problems in Children with Autism,100253,ZMH1,Special Emphasis Panel,,A1,1,229121,
8636720,R34,MH,1,N,02/03/2014,02/03/2014,01/31/2015,242,R34MH100254,SCHOOL OF MEDICINE &DENTISTRY,PAR-12-071,1R34MH100254-01A1,NIMH:229662\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,ROCHESTER,UNITED STATES,PEDIATRICS,28,041294109,US,UNIVERSITY OF ROCHESTER,NY,14627,"PUBLIC HEALTH RELEVANCE:  This collaborative, two-site study will develop and pilot the feasibility and efficacy of a eleven session behavioral parent training program for feeding problems in children with autism compared to a wait list group. Children between the ages of 2 and 7 years diagnosed with an autism spectrum disorder who also have feeding problems will be recruited for this 5 month study.            ",7713982;1908120 (contact);,"HYMAN, SUSAN L;SMITH, TRISTRAM H (contact);","GILOTTY, LISA ",02/03/2014,01/31/2017,Achievement;Address;Adherence (attribute);Aftercare;Age;autism spectrum disorder;Autistic Disorder;base;Behavior;Behavior Therapy;Behavioral;Bite;Caregivers;Child;Child health care;Child Nutrition;Childhood;Control Groups;cost effective;Data;Data Collection;data management;Day Care;design;Development;Diagnosis;Diet;Diet and Nutrition;Diet Monitoring;Eating;efficacy testing;Enrollment;Epidemiology;Equipment and supply inventories;Evaluation;Exhibits;experience;Family;feeding;flexibility;Food;Food Aversion;Future;Goals;Health Services Research;Home environment;indexing;innovation;Inpatients;Intervention;Intervention Studies;Literature;Measurement;Measures;Mental disorders;Modeling;Monitor;NIH Program Announcements;non-compliance;nutrition;Nutritional;Nutritional status;Outcome;Outpatients;Parent-Child Relations;parental involvement;Parenting behavior;Parents;Participant;Pilot Projects;Population;Prevalence;primary outcome;Problem behavior;Procedures;programs;Protocols documentation;Psychopharmacology;psychosocial;public health relevance;Questionnaires;Randomized;Randomized Clinical Trials;Records;Recruitment Activity;Reporting;Research;Research Personnel;response;Ritual compulsion;Sampling;Schedule;Schools;Sensory;Services;Shapes;Site;Stress;success;Testing;Time;tool;Training;Training Programs;treatment center;treatment duration;Treatment Efficacy;Universities;Waiting Lists,2/2-Treatment of Feeding Problems in Children with  Autism,100254,ZMH1,Special Emphasis Panel,,A1,1,229662,
8522816,R41,EY,1,N,02/01/2014,02/01/2014,01/31/2015,867,R41EY023482,,PA-12-089,1R41EY023482-01,NEI:159384\,SBIR-STTR,2014,NATIONAL EYE INSTITUTE,,SOLANA BEACH,UNITED STATES,,49,963348870,US,"SPINNAKER BIOSCIENCES, INC.",CA,920752047,"PUBLIC HEALTH RELEVANCE:  Visual impairment is a global epidemic affecting millions of individuals currently. A large portion of these individuals suffer from chronic age-related macular degeneration, which requires multiple injections of anti-proliferative pharmaceutics directly into the affected eye every year. The objective of this project is to develop a yearly or bi-yearly injectable ocular delivery system with the ability to prolong the release of active drug and to sel-report the amount of drug left in the system simultaneously, reducing the occurrence of injection-related complications and the cost of frequent re-visitations and post-injection examinations.                ",11358307;,"CHEN, MICHELLE Y.;","WUJEK, JEROME R",02/01/2014,01/31/2015,Affect;Age related macular degeneration;Anti-inflammatory;Anti-Inflammatory Agents;Antibodies;base;bevacizumab;Blood Vessels;Caliber;California;Chemistry;Chronic;Clinical Trials;cost;design and construction;Development;Digestion;Dimensions;Disease;Disease Progression;Doxorubicin;Drug Delivery Systems;Drug Formulations;Drug Kinetics;drug production;effective therapy;Electrolytes;Endophthalmitis;Epidemic;Excipients;Extravasation;Eye;Eye diseases;Fostering;Goals;improved;In Situ;in vivo;Individual;Injectable;Injection of therapeutic agent;intravitreal injection;Laboratory Research;laser photocoagulation;Left;Legal patent;Licensing;macula;macular edema;Methods;Monitor;nanomaterials;neovascularization;Operative Surgical Procedures;Ophthalmoscopes;Optics;particle;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacy (field);Phase;phase 2 study;Photochemotherapy;photonics;Porosity;Preparation;Process;Production;Proliferative Vitreoretinopathy;public health relevance;Reagent;Regimen;Reporting;Reproducibility;Research Personnel;Residual state;Retina;Retinal Detachment;Risk;scale up;Shapes;Silicon;Silicon Dioxide;Small Business Technology Transfer Research;Staging;Sterility;Surface;System;Technology;Temperature;Therapeutic;Therapeutic Agents;Thick;Tissues;Toxicology;Translations;Treatment Efficacy;Universities;Uveitis;Validation;Vascular Endothelial Growth Factors;Visual impairment,"Manufacture of Self-Reporting, Drug Loaded Porous Silicon Nanomaterials for Treat",23482,ZRG1,Special Emphasis Panel,,,1,159384,
8713686,R43,AI,1,N,02/07/2014,02/07/2014,10/31/2014,855,R43AI106239,,PA-13-234,1R43AI106239-01A1,NIAID:224899\,SBIR-STTR,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLLEGE STATION,UNITED STATES,,17,078432725,US,"AI BIOSCIENCES, INC.",TX,778454746,"PUBLIC HEALTH RELEVANCE: Chlamydia and gonorrhea are the most common sexually transmitted infections (STIs) in the US, causing serious long term health problems such as sepsis, stricture disease, pelvic inflammatory disease (PID), ectopic pregnancy and infertility. This project will advance the development of a POC multi-sample molecular diagnostic device for the rapid and inexpensive screening of STIs in non-traditional healthcare settings. AI Biosciences, Inc. will develop a low-cost portable nucleic acid (NA) extraction cartridge to deliver highly purified NA from urine and swab samples for real-time PCR amplification using a very low cost, automated, and rapid cycler to 8 reactions in under 20 min. Combining self-contained high quality NA extraction and rapid real-time thermal cycling will yield a 30-min molecular test that can identify two major STI pathogens in order for patients to receive immediate treatment before they leave a healthcare facility. After successful proof-of-concept work in Phase I, we aim to fully automate the system in Phase II.            ",7685647;,"WONG, SEASON S-S;","ROGERS, ELIZABETH ",02/07/2014,10/31/2014,Address;Advanced Development;Affect;Automation;base;Bathing;Bedside Testings;Biological Assay;Centers for Disease Control and Prevention (U.S.);Chlamydia;Chlamydia trachomatis;Clinic;Collaborations;commercialization;Communities;Consultations;cost;cost effective;Detection;detector;detention center;Development;Devices;Diagnosis;Diagnostic;Disease;Ectopic Pregnancy;Epidemic;Gonorrhea;Hand;Health;Health Care Costs;Health care facility;Healthcare;Healthcare Systems;Infection;Infertility;innovation;instrument;Jail;Left;Legal patent;Measures;Medical;meetings;Methods;Molecular;Motor;Neisseria gonorrhoeae;novel;Nucleic Acids;outreach;pathogen;Patients;Pelvic Inflammatory Disease;Performance;Phase;point of care;Point-of-Care Systems;Polymerase Chain Reaction;Positioning Attribute;Preparation;Prevalence;Process;public health medicine (field);public health relevance;Pump;Reaction;Reagent;Reporting;Rest;Sampling;screening;Sepsis;Sexually Transmitted Diseases;Signal Transduction;Swab;Syringes;System;Technology;Testing;Time;tool;Universities;Urine;Visit;Water;Work,"A rapid, accurate, and easy-to-use diagnostic assay for STIs",106239,ZRG1,Special Emphasis Panel,,A1,1,224899,
8707174,R43,AI,1,N,02/05/2014,02/05/2014,01/31/2015,855,R43AI107953,,PA-12-044,1R43AI107953-01A1,NIAID:299872\,SBIR-STTR,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,Bothell,UNITED STATES,,01,167580682,US,PHARMAIN CORPORATION,WA,98011,"PUBLIC HEALTH RELEVANCE:     This application proposes to formulate of two promising agents into various nanocarriers for in vitro testing. Selected formulations will be tested in vivo for their ability to increase survival hen administered 24-72 hours after a lethal radiation exposure. At the end of the project, we expect to have a working formulation from which data supporting an IND application can be collected. PharmaIN Corp Confidential            ",8597624;,"CASTILLO, GERARDO M;","RIOS, CARMEN ",02/05/2014,01/31/2016,Accident and Emergency department;Accidents;Acute;Address;Adenovirus Vector;Affect;analog;Animals;Apoptosis;Back;base;Binding (Molecular Function);Biological;Biological Markers;Blood;C57BL/6 Mouse;Cell Death;Cell division;Cell physiology;Cells;Cessation of life;Chronic;Complex;copolymer;crypt cell;Data;design;Development;dirty bomb;Dissociation;Dose;Drug Carriers;Drug Delivery Systems;Drug Formulations;Drug Kinetics;Effectiveness;efficacy testing;Electrolytes;Emergency Situation;Endothelial Cells;Ensure;Enzymes;Epithelial Cells;Event;Exposure to;FGF7 gene;Fibroblast Growth Factor;First Aid;Frequencies (time pattern);Functional disorder;functional restoration;gastrointestinal;Gastrointestinal tract structure;Goals;Growth;Growth Factor;Half-Life;Health;Hematopoietic;Hematopoietic System;Hemorrhage;Hour;improved;In Vitro;in vitro testing;in vivo;Infection;Inflammation;Injectable;Injection of therapeutic agent;Injury;Intestines;Intravenous infusion procedures;intravenous injection;Ionizing radiation;keratinocyte growth factor;Lead;Lethal Dose 50;Maximum Tolerated Dose;Mediating;Medical;Mucositis;nanocarrier;Nanotechnology;Nuclear Warfare;nutrition;Organ;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Polyethylene Glycols;Polymers;portability;prevent;Principal Investigator;Production;programs;Proteins;proto-oncogene protein kfgf;Radiation;Radiation induced damage;Radiation Injuries;Radiation therapy;Recovery;Regimen;repaired;residence;restoration;Self Administration;Self-Administered;Sepsis;Serum;Site;Stem cells;subcutaneous;success;Syndrome;Syringes;System;Technology;Testing;Time;Vascular Permeabilities;vector;Villus;Viral Vector;Weight;Whole Organism;Whole-Body Irradiation;Work,Medical countermeasure after radiation exposure,107953,ZRG1,Special Emphasis Panel,,A1,1,299872,
8732202,R43,AI,1,N,02/05/2014,02/05/2014,01/31/2015,855,R43AI112467,,PA-13-234,1R43AI112467-01,NIAID:225000\,SBIR-STTR,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN DIEGO,UNITED STATES,,52,780230004,US,"AMPLYX PHARMACEUTICALS, INC.",CA,921225946,"PUBLIC HEALTH RELEVANCE: Cryptococcal meningitis (CM) is a significant cause of mortality among HIV positive individuals and transplant patients, and a major world-wide health concern in developing regions including Africa and Southeast Asia where mortality rates reach 70%. There is a clear need for new, cost effective therapeutics which will enable patient compliance with treatment regimens. Amplyx proposes to create a new class of orally available antifungal drugs with fungicidal activity against cryptococcus which will simplify and reduce the duration of treatment regimens, and lower the mortality rates due to cryptococcosis.            ",1880590;,"MUTZ, MITCHELL W;","XU, ZUOYU ",02/05/2014,01/31/2015,Acquired Immunodeficiency Syndrome;Acute;Adverse effects;Africa;Africa South of the Sahara;AmBisome;Amphotericin B;analog;Animal Model;Antifungal Agents;Arrhythmia;Aspergillus fumigatus;aureobasidin A;base;Biological Availability;Candida albicans;Cell Survival;Cells;Ceramides;Cessation of life;Chemicals;Chemistry;Compliance behavior;cost effective;Cryptococcal Meningitis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Cyclic Peptides;cytotoxicity;Data;design;Drug Formulations;Drug resistance;Exhibits;Fluconazole;Flucytosine;fungus;General Population;Generic Drugs;Genome;Goals;Health;HIV;HIV Seropositivity;Human;improved;Incidence;Individual;Industrial fungicide;Infection;inhibitor/antagonist;Inositol;Left;Legal patent;Leukopenia;Libraries;Lipids;Liposomes;Maintenance Therapy;Mammals;Methods;Mortality Vital Statistics;Neoadjuvant Therapy;nephrotoxicity;North America;Oral;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Phase I Clinical Trials;Property;Protons;public health relevance;Relative (related person);resistant strain;Sales;Screening Result;Southeastern Asia;Specificity;Sphingolipids;Testing;theories;Therapeutic;Toxic effect;Transplant Recipients;Treatment outcome;Treatment Protocols;Tuberculosis;Virulence,Discovering a Targeted Inositol Phosphorylceramide Synthase Inhibitor to Improve,112467,ZRG1,Special Emphasis Panel,,,1,225000,
8644987,R43,EY,1,N,02/01/2014,02/01/2014,01/31/2015,867,R43EY023504,,PA-13-088,1R43EY023504-01A1,NEI:220350\,SBIR-STTR,2014,NATIONAL EYE INSTITUTE,,SHOREVIEW,UNITED STATES,,04,174413419,US,MSP CORPORATION,MN,551265028,"PUBLIC HEALTH RELEVANCE: This proposed project is relevant to public health as it addresses an important need in ocular health, i.e. inhibition of scar tissue growth in retinal detachment, which results in failures of retinal reattachment surgeries. Using a novel device, this work would enable delivery of a scar-inhibiting drug at the time of the surgery, so as to improve the visual outcome for the patients prone to retinal scar tissue growth.            ",1973831;,"NAQWI, AMIR A;","WUJEK, JEROME R",02/01/2014,01/31/2015,Address;aerosolized;Aerosols;Affect;Air;Animal Model;Animals;Anterior;Area;Aspirate substance;base;Businesses;Cells;Choroid;Cicatrix;Ciliary epithelium;Cleaved cell;Clinical Trials;cohort;Collagen;Commit;Complication;Control Groups;Development;Device or Instrument Development;Devices;dispase;dosage;Dose;Drug Delivery Systems;Ensure;Environment;Epithelial Cells;Evaluation;Evolution;Experimental Models;Eye;Failure (biologic function);Family suidae;FDA approved;Fibronectins;Frequencies (time pattern);Functional disorder;Future;Gases;Generations;Goals;Growth;Health;Human;human disease;improved;Injection of therapeutic agent;injured;Injury;Intervention;Lead;Liquid substance;Marketing;Measures;Medical;Medical Device;meetings;Mitomycins;Modeling;Needles;Neuroglia;novel;Operating Rooms;Operative Surgical Procedures;Ophthalmology;Optic Nerve;Outcome;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phase;phase 1 study;Pilot Projects;pre-clinical;Process;Proliferative Vitreoretinopathy;public health medicine (field);public health relevance;Recurrence;Research;Research Personnel;Retina;Retinal;Retinal Detachment;Safety;safety study;Saline;salt balance;Shapes;Site;Solutions;Structure of retinal pigment epithelium;Surface;Surgical Equipment;Technology;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Toxic effect;Traction;Universities;Visual;Vitrectomy;Work,Intraocular Aerosol Treatment for Inhibition of Proliferative Vitreoretinopathy,23504,ZRG1,Special Emphasis Panel,,A1,1,220350,
8650040,R43,EY,1,N,02/01/2014,02/01/2014,01/31/2015,867,R43EY023920,,PA-13-088,1R43EY023920-01A1,NEI:215420\,SBIR-STTR,2014,NATIONAL EYE INSTITUTE,,CHESTER SPRINGS,UNITED STATES,,06,012383843,US,"CATALYST, LLC",PA,194253846,"PUBLIC HEALTH RELEVANCE: Eye pain: By far the most the most frequent cause of serious eye pain is trauma, caused by a variety of situations. Remarkably, there are no good ways to manage eye pain today, a situation that can be literally excruciating to children with eye injury and their often frantic parents. The Sarentis small-molecule-based pharmaceuticals described below represent a completely new approach to ophthalmic pain relief that can be used to manage pain associated with eye emergencies and routine injuries. In contrast, conventional analgesic drugs given by mouth or by IV are largely ineffective for treating severe corneal pain, as the cornea is avascular and equilibrates slowly and inefficiently with compounds in circulation. Existing topical (local) anesthetics like lidocaine are highly effective in eliminatin pain. However, and unfortunately, they are highly toxic to corneal cells and can be used only briefly during surgery or emergency care. Consequently, there are no truly successful acute or long-term therapies for eye pain currently available. In fact, there is not one word on the topic i the AMA Pediatric Pain Management CME document 1. Importantly, and unlike other agents, the Sarentis peptides applied topically do not impair the healing process. Impaired healing can lead to delayed wound closure, infections, scarring, hazing in the corneal, inflammation and potential loss of vision. Because of their lack of toxicity, the Sarentis peptides can be applied repeatedly to provide extended periods of pain control. This potential to relieve human (and animal) suffering and the lack of existing commercial alternatives suggest that Sarentis is well positioned to successfully address an unmet, significant, global need. Substantial basic and preclinical data support the potential utility of the neuropeptide approach. The next essential step is to develop appropriate formulations and delivery vehicles to take these compounds ahead to definitive toxicology and Phase I clinical trials.            ",11660564;,"BHARGAVA, KUMARIL;","WUJEK, JEROME R",02/01/2014,01/31/2015,Acute;Address;Adult;Affect;Agonist;Amino Acids;Analgesics;Animal Model;Animals;Aspirin;base;Blindness;Blood Circulation;Cells;Child;Childhood;Chronic;Cicatrix;Clinical;clinical efficacy;Clinical Trials;Codeine;commercialization;Cornea;Corneal pain;Data;Development;Development Plans;Distress;Dose;Drug Formulations;Drug Stability;Emergency Care;Emergency Situation;Environment;Eye;Eye Injuries;Family member;Funding;Gel;Goals;Grant;hazing;Hospitals;Hour;Human;Human Resources;Hydrocortisone;Ibuprofen;Impaired wound healing;Infection;Inflammation;Injury;innovation;irritation;Isotonic Exercise;Lead;Legal patent;Lidocaine;Life;Local Anesthetics;manufacturing scale-up;Military Personnel;Molecular;Morphine;Neuropeptides;Neurotensin;novel;novel strategies;ocular pain;Operative Surgical Procedures;Ophthalmologist;Oral cavity;Pain;Pain management;Paralysed;Parents;Peptides;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I Clinical Trials;Positioning Attribute;pre-clinical;Process;Property;public health relevance;Research;response;small molecule;Steroids;Structure;success;Testing;Time;Topical application;Toxic effect;Toxicology;Trauma;wound,Ocular Formulation Development of Innovative Novel Compounds with superior ocular,23920,ZRG1,Special Emphasis Panel,,A1,1,215420,
8646108,R43,EY,1,N,02/01/2014,02/01/2014,01/31/2015,867,R43EY024185,,PA-13-088,1R43EY024185-01,NEI:224092\,SBIR-STTR,2014,NATIONAL EYE INSTITUTE,,SAN DIEGO,UNITED STATES,,52,828902515,US,"CRINETICS PHARMACEUTICALS, INC.",CA,921214727,"PUBLIC HEALTH RELEVANCE: This project's goal is to develop a novel class of nonpeptide somatostatin receptor agonists as agents for ophthalmic diseases, particularly retinopathies, that would not require the intravitreal injections of current therapies. If successful, this work wll ultimately provide candidates that could be optimized for clinical trials.            ",10740226;,"BETZ, STEPHEN F;","WUJEK, JEROME R",02/01/2014,01/31/2015,"Acromegaly;Adverse effects;age related;Age related macular degeneration;Aging;Agonist;American;Animal Model;Antibodies;Aqueous Humor;bevacizumab;Biological Assay;Blood-Retinal Barrier;Cells;Choroid;Choroidal Neovascularization;Clinical Trials;Coculture Techniques;Complement;Conjunctival Hemorrhage;design;Diabetes Mellitus;Diabetic Retinopathy;Disease;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;Epidemic;Evaluation;Eye;Eye diseases;fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether;Funding;G Protein-Coupled Receptor Genes;Goals;Government;Growth;Guidelines;Hand;Hormones;Human;In Vitro;in vitro Assay;in vivo;in vivo Model;Inflammation;innovation;intravitreal injection;Lasers;Lead;Libraries;Macular degeneration;Methods;Modeling;molecular modeling;Molecular Models;Neuropeptides;next generation;novel;novel therapeutics;ocular pain;Older Population;Oryctolagus cuniculus;Patients;Penetration;Peptides;Peripheral;Permeability;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetic model;Pharmacologic Substance;Pharmacology;Phase;Physiologic Intraocular Pressure;Plasma;Posterior eyeball segment structure;pre-clinical;Pre-Clinical Model;programs;Property;Proteins;public health relevance;receptor;Receptor Activation;research clinical testing;research study;Retina;Retinal Detachment;Retinal Diseases;scale up;Series;Small Business Innovation Research Grant;Somatostatin;Somatostatin Receptor;Staging;success;Testing;Therapeutic;Tight Junctions;Tissues;Toxicology;tumor;Vitreous Detachment;vitreous floater;Vitreous humor;Work",Peripheral administration of nonpeptide somatostatin agonists for ophthalmic dise,24185,ZRG1,Special Emphasis Panel,,,1,224092,
8644994,R43,HL,1,N,02/06/2014,02/06/2014,02/05/2015,837,R43HL117399,,PA-13-088,1R43HL117399-01A1,NHLBI:241398\,SBIR-STTR,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,RESEARCH TRIANGLE PARK,UNITED STATES,,04,141881727,US,"COGNOSCI, INC.",NC,277092076,"PUBLIC HEALTH RELEVANCE: Asthma is a chronic inflammatory disease affecting the airways and the ability of the patient to properly breath. With over 300 million patients worldwide, and more than 24 million patients in the United States, Americans annually spend over $56 billion on healthcare for asthma patients. We are proposing to develop a new class of therapeutic agents for the treatment of asthma. These agents are based upon COG-compounds, which are small fragments of apolipoprotein-E with powerful anti-inflammatory activities that may directly and/or indirectly affect airway remodeling.        ",1867021;,"VITEK, MICHAEL PETER;","NOEL, PATRICIA ",02/06/2014,02/05/2015,Adrenal Cortex Hormones;Affect;Air;airway hyperresponsiveness;airway inflammation;Airway Obstruction;airway remodeling;American;Animals;Anti-Asthmatic Agents;Anti-inflammatory;Anti-Inflammatory Agents;Apolipoprotein E;apolipoprotein E-1;Asthma;Back;base;Breathing;Bronchial Spasm;Bronchoalveolar Lavage Fluid;Bronchodilator Agents;Canis familiaris;Cell model;Cells;Chest;Chronic;Chronic Obstructive Airway Disease;Clinic;Clinical;cost;Coughing;cytokine;Data;Detection;Development;Dexamethasone;Disease;Dose;eosinophil;Extrinsic asthma;fluticasone;Fostering;functional restoration;Goblet Cells;good laboratory practice;Grant;Healthcare;Hyperplasia;IgE;Inflammation;Inflammation Mediators;Inflammatory;inhibitor/antagonist;Interleukin-2;Interleukin-4;Investigational Drugs;Investigational New Drug Application;Lead;Left;Link;Literature;Low Density Lipoprotein Receptor;Lung;macrophage;Marketing;Maximum Tolerated Dose;Measures;Medicine;methacholine;mimetics;Modeling;mouse model;Mus;neutrophil;novel;Obstruction;Patients;Peptides;Pharmaceutical Preparations;Phase;Phosphoric Monoester Hydrolases;Plasma;Protein phosphatase;protein phosphatase 2A inhibitor 2;Protocols documentation;public health relevance;Publishing;Pulmonary Emphysema;Pyroglyphidae;Rattus;receptor;Reporting;Research;research study;Resistance;response;safety study;Serum;Shortness of Breath;Small Business Innovation Research Grant;Smooth muscle (tissue);Steroid Resistance;Steroids;Symptoms;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Time;Toxic effect;U937 Cells;United States;United States Food and Drug Administration;Western Blotting;Wheezing;Work,Inhibitor #2 of Protein Phosphatase 2A (I2PP2A) and Asthma,117399,ZRG1,Special Emphasis Panel,,A1,1,241398,
8651580,R43,HL,1,N,02/06/2014,02/06/2014,02/05/2015,837,R43HL118926,,PA-13-088,1R43HL118926-01A1,NHLBI:208212\,SBIR-STTR,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,Houston,UNITED STATES,,07,786704143,US,"PULMOTECT, INC",TX,77027,"PUBLIC HEALTH RELEVANCE: Pulmotect, Inc is developing novel therapeutics that stimulate the innate immune system to protect against infectious diseases, even in cases of severely compromised immunity. Proof-of-concept data has shown that this technology effectively protects against a broad range of inhaled pathogens. This project will provide significant data to help transition this technology from the lab to the clinic for viral infections. This work will leverage ongoing activities currently underway developing the technology for cancer patients.        ",8802235;,"SCOTT, BRENTON;","CALER, ELISABET V",02/06/2014,02/05/2015,"Address;Animal Model;Attenuated;base;Birds;Breathing;California;Cancer Patient;Cessation of life;Clinic;commercialization;Communicable Diseases;Consultations;Data;Data Set;Defense Mechanisms;design;Dose;Environment;FDA approved;Foundations;Funding;Human;Immune system;Immunity;Immunocompromised Host;In Vitro;in vivo;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;interest;Lead;Ligands;Lung;Marketing;Measurable;Measures;Modeling;Mortality Vital Statistics;new technology;novel therapeutics;Oseltamivir;pandemic disease;pathogen;Pharmaceutical Preparations;Phase;phase 1 study;Phase I Clinical Trials;Pneumonia;Population;pre-clinical;prevent;Prevention;Process;public health relevance;research study;respiratory;Respiratory Tract Infections;Risk;Safety;seasonal influenza;Small Business Innovation Research Grant;Solutions;Technology;Texas;Time;Toxic effect;treatment duration;Viral;Virus;Virus Diseases;Work",Boosting the innate immune system of the lungs to prevent and treat respiratory v,118926,ZRG1,Special Emphasis Panel,,A1,1,208212,
8646021,R43,NR,1,N,02/06/2014,02/07/2014,09/30/2014,361,R43NR014382,,PA-13-088,1R43NR014382-01A1,NINR:223149\,SBIR-STTR,2014,NATIONAL INSTITUTE OF NURSING RESEARCH,,TEMPE,UNITED STATES,,09,949188754,US,"GOALISTICS, LLC",AZ,85284,"PUBLIC HEALTH RELEVANCE: The long-term goal of the proposed project is the development and testing of the effectiveness of the Partner Pain Support Program (PPSP), a web-based psychoeducational self-help system for partners/spouses of individuals with chronic pain. The program will provide training for partners to enhance effective pain management support and help partners in coping with the challenges and burdens of living with and/or loving someone with chronic pain. The PPSP is based on fundamental, evidence-based, cognitive-behavioral, interpersonal, and motivational perspectives on chronic pain management. The program has the potential to provide scientifically sound information to large numbers of individuals at low cost.            ",9696870;,"RUEHLMAN, LINDA SUE;","COTTON, PAUL ",02/07/2014,09/30/2014,Achievement;Address;Affect;Area;base;Behavioral;biopsychosocial;chronic pain;Cognitive;Commit;Communication;Companions;Computer software;Computers;coping;cost;cost effective;Couples;Data;Databases;design;Development;Doctor of Philosophy;Effectiveness;emotion regulation;evidence base;experience;flexibility;Foundations;Goals;Image;Individual;innovation;Intervention;joint function;Knowledge;Learning;Life;Love;Maintenance;member;Modification;Multimedia;Nature;Online Systems;Outcome;Pain;Pain management;Persons;Phase;Play;Process;programs;prototype;psychoeducational;psychologic;Psychologist;public health relevance;Research;Resources;Role;Self Care;self help;Self Management;Site;skills;social;Social Environment;Social Network;software development;sound;Spouses;stress management;Support Groups;Surveys;System;Tablets;Telephone;Testing;Text;Therapeutic;Training;web site,Development of the Partner Pain Support Program,14382,ZRG1,Special Emphasis Panel,,A1,1,223149,
8624955,U01,CA,1,N,02/07/2014,02/07/2014,01/31/2015,394,U01CA182364,SCHOOLS OF MEDICINE,PAR-13-036,1U01CA182364-01,NCI:635725\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212,"PUBLIC HEALTH RELEVANCE: In the proposed study, we will first unravel functional variants and identify new rare variants and then prospectively evaluate if calcium-gene interactions affect different stages of carcinogenesis, confer protection beyond endoscopic screening, and discover the underlying mechanism(s) for these interactions. The PLCO cohort provides a very unique and unparalleled opportunity to prospectively examine these hypotheses. This study will be essential for translating these novel findings to personalized prevention strategies for colorectal cancer by identifying high risk populations, thus, maximizing the benefits and minimizing potential adverse effects of high calcium intake.            ",7736698 (contact);10414471;,"DAI, QI  (contact);EDWARDS, TODD L;","ZHU, CLAIRE ",02/07/2014,11/30/2018,absorption;Address;adenoma;Adverse effects;Affect;Alleles;arm;base;Calcium;calcium intake;cancer chemoprevention;Cancer Etiology;Candidate Disease Gene;carcinogenesis;Cessation of life;Chloride Ion;Chlorides;cohort;Colon;Colonoscopy;Colorectal Adenoma;Colorectal Cancer;Consumption;Dinoprostone;Disease;DNA Resequencing;driving force;Endoscopy;Epidemiologic Studies;Functional disorder;Gene Frequency;gene interaction;Genes;Genotype;high risk;Homeostasis;Hormones;hypercalciuria;Hyperplastic Polyp;Hyperprostaglandin E syndrome;Incidence;Individual;Intervention;inward rectifier potassium channel;Joints;KCNJ1 gene;Kidney;Left;Link;Malignant Neoplasms;Measures;Medicine;Minor;Molecular;Mortality Vital Statistics;Mutation;Myocardial;Natural History;novel;Parathyroid gland;Phase;Population;Potassium;prevent;Prevention strategy;Primary Prevention;Prostate;public health relevance;Recurrence;Regulation;Reporting;Resources;Risk;screening;Serum;Side;Single Nucleotide Polymorphism;Sodium;sodium-potassium chloride cotransporter 2 protein;Staging;Translating;United States National Institutes of Health;Variant;Vitamin D;wasting,Translating gene-calcium interactions to precision medicine for colorectal cancer,182364,ZCA1,Special Emphasis Panel,,,1,635725,
8639877,U01,HL,1,N,02/07/2014,02/07/2014,01/31/2015,837,U01HL121838,BIOMED ENGR/COL ENGR/ENGR STA,PAR-13-029,1U01HL121838-01,NHLBI:683344\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,ENGINEERING (ALL TYPES),05,097394084,US,GEORGIA INSTITUTE OF TECHNOLOGY,GA,303320420,"PUBLIC HEALTH RELEVANCE: Many transcatheter procedures used for treatment of structural heart diseases are demanding and protracted. Success and complications can be improved by adequate image guidance. Our partnership of clinicians and engineers is planning to develop a new catheter based ultrasound system which can also be used under MRI to image inside the heart to reduce the duration of complex procedures, minimizing radiation exposure to the patient and improving the results.                  ",8245590 (contact);7866715;,"DEGERTEKIN, FAHRETTIN L (contact);LEDERMAN, ROBERT J;","OLIVE, MICHELLE ",02/07/2014,01/31/2017,"3-Dimensional;Address;Adult;Affect;Animal Model;Animals;Architecture;Atrial Heart Septal Defects;auricular appendage;base;Beryllium;Biological;Caliber;Cardiac;Cardiomyopathies;Cardiovascular system;Catheterization;Catheters;Child;Childhood;Clinical;clinical application;Clinical Trials;Code;Collaborations;Complex;Custom;Data;Denmark;design;Development;Devices;Diagnostic radiologic examination;Disease;Doctor of Philosophy;Effectiveness;Electronics;Engineering;Exposure to;Face;Frequencies (time pattern);Future;Goals;Heart;Heart Diseases;Human;Image;image guided intervention;image processing;improved;In Vitro;in vitro testing;in vivo;Institution;Intervention;Left;Magnetic Resonance Imaging;Microfabrication;microsystems;Miniaturization;National Heart, Lung, and Blood Institute;novel;operation;Operative Surgical Procedures;Outcome;Pathology;Patients;Performance;Phase;Phase I Clinical Trials;Population;pre-clinical;preclinical evaluation;Preclinical Testing;Procedures;Process;prototype;public health relevance;Radiation;repaired;research clinical testing;Resources;Roentgen Rays;Route;Safety;Sampling;Scheme;Silicon;software development;Structure;success;Symptoms;System;Systems Development;Technology;Testing;Time;Translating;transmission process;Ultrasonography;United States National Institutes of Health;Universities;valve replacement;Ventricular Septal Defects;Work",MRI-safe 3Dl intracardiac ultrasound catheter for cardiovascular intervention,121838,ZHL1,Special Emphasis Panel,,,1,683344,
8474330,U10,EY,1,N,02/04/2014,02/01/2014,12/31/2014,867,U10EY023198,SCHOOLS OF MEDICINE,PAR-10-207,1U10EY023198-01,NEI:275036\,Other Research Related,2014,NATIONAL EYE INSTITUTE,,DURHAM,UNITED STATES,OPHTHALMOLOGY,04,044387793,US,DUKE UNIVERSITY,NC,27705,"PUBLIC HEALTH RELEVANCE:  This project will have a significant impact on pediatric eye care and on quality of life of children. Much of pediatric eye care practice is based on clinical impression or limited evidence, and conducting the proposed studies will provide the high-level evidence needed to guide the management of common childhood eye diseases such as amblyopia, strabismus, cataract, intraocular inflammation, and refractive error.                 ",7852457;,"WALLACE, DAVID K;","EVERETT, DONALD F",02/01/2014,12/31/2018,Address;Amblyopia;Applications Grants;base;Botulinum Toxins;Caring;Cataract;Cataract Extraction;Child;Childhood;Chronic Childhood Arthritis;Clinical;Clinical Research;Clinical Trials;computerized;Convergence Insufficiency;Cornea;cost effectiveness;Development;disease registry;effectiveness research;Esotropia;Exotropia;Eye;Eye diseases;Eyeglasses;Family;Funding;Future;Hyperopia;impression;Incidence;Inflammation;Level of Evidence;Measures;Methods;Myopia;Nasolacrimal duct structure;Obstruction;operation;Operative Surgical Procedures;Ophthalmologist;Optometrist;Outcome Measure;Pilot Projects;Principal Investigator;Procedures;Protocols documentation;public health relevance;Quality of life;randomized trial;Refractive Errors;Research Personnel;Risk Factors;Site;Strabismus;Testing;Thick;Time;Training;treatment strategy;Uveitis;Visual;Visual Acuity,PEDIATRIC EYE DISEASE INVESTIGATOR GROUP: CHAIR'S OFFICE,23198,ZEY1,Special Emphasis Panel,,,1,275036,
8537650,U79,SM,1,N,09/12/2012,09/30/2012,09/29/2013,,U79SM061192,,RFA-SM-12-007,1U79SM061192-01,,Unknown,2012,Center for Mental Health Services,,ANN ARBOR,UNITED STATES,,12,073133571,US,UNIVERSITY OF MICHIGAN,MI,481091274,,11553710;,"KAPLOW, JULIE;","CURL, KENNETH ",09/30/2012,09/29/2016,,The Trauma and Grief Clinic for Youth: Promoting Community-Wide Best Practices,61192,ZOA1,Special Emphasis Panel,,,1,,
8609657,P30,CA,2,N,02/04/2014,02/04/2014,11/30/2014,397,P30CA014195,,PAR-12-298,2P30CA014195-41,NCI:1235132\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,,49,078731668,US,SALK INSTITUTE FOR BIOLOGICAL STUDIES,CA,920371002,,1866203;,"HUNTER, TONY R.;","CIOLINO, HENRY P.",12/31/1996,11/30/2018,Bioinformatics;Biophotonics;Cancer Center Support Grant;Core Facility;Equipment;Flow Cytometry;functional genomics;Gene Transfer;Genomics;Peptide Synthesis;Proteomics;Research Support;therapeutic target;Transgenic Mice,Cancer Center Support Grant,14195,NCI,Subcommittee B - Comprehensiveness,,,41,1235132,
8631710,R01,AA,2,N,02/04/2014,02/05/2014,01/31/2015,273,R01AA013746,SCHOOLS OF MEDICINE,PA-11-260,2R01AA013746-11,NIAAA:632268\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHICAGO,UNITED STATES,PSYCHIATRY,01,005421136,US,UNIVERSITY OF CHICAGO,IL,60637,"PUBLIC HEALTH RELEVANCE: Understanding the factors contributing to development and persistence of excessive alcohol consumption is crucial for improved prevention, education and intervention strategies. Our unique integration of human laboratory alcohol challenge and longitudinal assessment of drinking behaviors and consequences over time will provide critical tests of the prospective role of stimulating, rewarding, and sedating alcohol responses to escalations and maintenance of excessive drinking.            ",1878144;,"KING, ANDREA C;","MATOCHIK, JOHN A",07/01/2002,01/31/2019,Accidents;Acute;Addictive Behavior;Adult;Adverse effects;Age;age related;Aging;Alcohol abuse;Alcohol dependence;alcohol effect;alcohol exposure;alcohol response;alcohol sensitivity;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Award;Behavior;Behavioral;binge drinker;binge drinking;Brain;Chicago;cohort;cost;Crime;design;Development;Dopamine;drinking;drinking behavior;Educational Intervention;Emotional;evidence base;Exhibits;follow-up;Fostering;Frequencies (time pattern);Funding;Future;Goals;Healthcare;Heavy Drinking;hedonic;high risk;Human;Hydrocortisone;improved;Incentives;innovation;insight;Intervention;Investigation;Knowledge;Laboratories;Laboratory Study;Lead;Life;Light;Link;Maintenance;model development;Modeling;Neurobiology;Participant;Persons;Phase;Physiological;Placebo Control;Placebo Effect;Placebos;Prevention;Prevention education;problem drinker;Process;productivity loss;prospective;public education;public health relevance;Relative (related person);Reporting;response;reward circuitry;Rewards;Risk;Risk Factors;Role;Sampling;Sedation procedure;sedative;Severities;social;Symptoms;Testing;Time;trend,Alcohol Stimulation and Sedation in Binge Drinkers,13746,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,,11,632268,
8629289,R01,AA,2,N,02/04/2014,02/05/2014,01/31/2015,273,R01AA016838,SCHOOLS OF PUBLIC HEALTH,PA-11-016,2R01AA016838-06A1,NIAAA:688696\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PROVIDENCE,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,01,001785542,US,BROWN UNIVERSITY,RI,02912,"PUBLIC HEALTH RELEVANCE: Early use of alcohol is associated with increased risk of a number of subsequent short- and long-term adverse outcomes, including heavy or problem drinking, likelihood of developing an alcohol use disorder, other substance involvement, and behavioral problems. It is only by understanding the course of alcohol use during adolescence that we can implement successful prevention strategies to reduce underage drinking and ultimately improve the mental and physical health of our population.            ",6382896;,"JACKSON, KRISTINA MELIA;","WHITE, AARON ",05/01/2007,01/31/2019,Adolescence;adverse outcome;Age;age difference;Age of Onset;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol involvement;alcohol related problem;alcohol use disorder;alcohol use initiation;Alcohols;base;Cereals;Cognition;Cognitive;cohort;Complement;Data;Data Collection;design;Development;Dimensions;drinking;drinking onset;Drug usage;early alcohol use;early drinking;Enrollment;experience;Familiarity;Funding;Growth;Heavy Drinking;high school;Illicit Drugs;improved;Individual;Individual Differences;innovation;Internet;Intoxication;Knowledge;Licensing;Life;Maintenance;Mental Health;middle school;Modeling;multilevel analysis;Online Systems;Outcome;Participant;Performance;Persons;physical conditioning;Population;Prevention;Prevention strategy;Problem behavior;Process;prospective;Prospective Studies;Puberty;public health medicine (field);public health relevance;Request for Applications;Research;response;Risk;Risk Factors;Role;Sampling;scaffold;Schedule;Shapes;Social Development;Social Network;Staging;success;Surveys;Survival Analysis;Syndrome;Techniques;Testing;Time;Tobacco;twelfth grade;underage drinker;underage drinking;underage drinking reduction;Variant;willingness;Youth,Initiation and Progression through Early Drinking Milestones in Underage Drinkers,16838,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,A1,6,688696,
8696949,R01,AI,2,N,02/04/2014,02/05/2014,01/31/2015,855,R01AI074856,SCHOOLS OF ARTS AND SCIENCES,PA-11-260,2R01AI074856-06,NIAID:329301\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LAWRENCE,UNITED STATES,BIOLOGY,02,076248616,US,UNIVERSITY OF KANSAS LAWRENCE,KS,660457568,"PUBLIC HEALTH RELEVANCE: Before the age of antibiotics about 80 years ago, infectious diseases were the major cause of mortality in humans. Thus, the increased incidence of antibiotic resistance in bacterial pathogens poses a major public health concern. Many pathogens that cause millions of death worldwide and are major agents of food- borne outbreaks, bubonic plague, and secondary hospital infections require the assembly of a bacterial needle-like nanoinjector for pathogenesis. The proposed research seeks to determine how bacteria assemble the nanoinjector by determining the protein-protein interactions of its components. This knowledge is important in designing novel anti-infectives, which will prevent pathogens from invading human cells but will not contribute to the development of antibiotic resistance.            ",8162661;,"DE GUZMAN, ROBERTO N;","MUKHOPADHYAY, SUMAN ",07/01/2007,01/31/2019,Address;Age;Anti-Infective Agents;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Proteins;base;Binding (Molecular Function);Biological Assay;Biology;Bubonic Plague;Cartoons;Cell membrane;Cells;Cessation of life;Communicable Diseases;Complement;Complex;Crystallography;Cytoplasm;Data;design;Development;Disease;Electron Microscopy;Electrons;FDA approved;foodborne outbreak;Funding;Human;in vivo;Incidence;Invaded;Joints;Knowledge;macromolecular assembly;Membrane;Minor;Molecular Chaperones;Mortality Vital Statistics;Mutagenesis;nano;Needles;Nosocomial Infections;novel;pathogen;Pathogenesis;prevent;Protein Export Pathway;protein protein interaction;Proteins;Pseudomonas;Pseudomonas aeruginosa;public health medicine (field);public health relevance;Publications;Puncture procedure;Research;Salmonella;Salmonella typhimurium;Shigella;Shigella flexneri bacterium;Structure;success;Surface;Testing;Type III Secretion System Pathway;Vaccines;Virulence;Yersinia;Yersinia pestis,NMR studies of bacterial needle and tip proteins,74856,MSFC,Macromolecular Structure and Function C Study Section,,,6,329301,
8695252,R01,DC,2,N,02/01/2014,02/01/2014,01/31/2015,173,R01DC005960,BIOMED ENGR/COL ENGR/ENGR STA,PA-11-260,2R01DC005960-09,NIDCD:533873\,Research Projects,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,STANFORD,UNITED STATES,ENGINEERING (ALL TYPES),18,009214214,US,STANFORD UNIVERSITY,CA,943056203,"PUBLIC HEALTH RELEVANCE: The lack of knowledge about the relationships between middle-ear structures and sound transmission has resulted in unsatisfactory and variable outcomes of middle-ear repairs, particularly at high frequencies where sound localization cues may be important for hearing in noisy situations. The proposed research is significant for hearing health because it will provide a basis for understanding the role the flexible ossicular chain plays in the sensitivity of mammalian hearing through both the air- and bone- conduction pathways. The experiments and models will contribute to our understanding of the protective role of flexibility in the three-bone ossicular chain, the role of 3D ossicular modes in reducing inertia and improving high-frequency hearing in the normal ear, and the functioning of pathological (e.g., otosclerotic) and surgically repaired middle ears with a prosthesis. The proposed research is also significant because it will clarify the role of ossicular chain mass and flexibility on bone-conduction hearing, which could lead to improved bone conduction diagnostics and hearing devices.            ",1888316;,"STEELE, CHARLES RICHARD;","WATSON, BRACIE ",04/01/2003,01/31/2019,Accounting;Adopted;Affect;Air;Amphibia;Anatomy;Animals;Area;arm;Attention;base;Birds;blood pump;bone;Bone Conduction;Breathing;Characteristics;Chiroptera;Clinical;Cochlear structure;Complex;Computer Simulation;Coupling;cranium;Cues;Data;design;Devices;Diagnostic;Ear ossicle structure;Ear structure;External auditory canal structure;Felis catus;flexibility;Foundations;Freedom;Frequencies (time pattern);Goals;Hair;Head;Health;Hearing;Human;improved;Incus structure;joint function;Joints;Knowledge;Lead;Liquid substance;Malleus;Mammals;Measurement;Measures;middle ear;Milk;Modeling;Modification;Modiolus;Morphology;Motion;Mus;Operative Surgical Procedures;Otosclerosis;Outcome;Pathology;Pathway interactions;Patients;Perception;Physiological;Play;pressure;prevent;Process;Production;Prosthesis;Prosthesis Design;public health relevance;reconstruction;Relative (related person);repaired;Reptiles;Research;research study;response;Rods (Retina);Role;Route;Solid;sound;Sound Localization;Specimen;Stapes;Stimulus;Structure;Synovial Fluid;System;Temporal bone structure;Testing;theories;three-dimensional modeling;transmission process;Tympanic membrane structure;Ultrasonics;vibration;virtual;vocalization,Why do mammals have a flexible three-bone ossicular chain?,5960,ZRG1,Special Emphasis Panel,,,9,533873,
8629658,R01,DC,2,N,02/06/2014,02/06/2014,01/31/2015,173,R01DC008080,,PA-11-260,2R01DC008080-06,NIDCD:316532\,Research Projects,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,Macquarie University,AUSTRALIA,,,751653940,AS,AUSTRALIAN HEARING SERVICES,,NSW 2109,PUBLIC HEALTH RELEVANCE: This study examines the effectiveness of universal newborn hearing screening (UNHS) by taking advantage of a unique research and service environment in Australia to conduct a population-based study comparing outcomes of early- and late-identified children in a prospective manner. This study will generate definitive evidence on the impact of congenital permanent hearing loss on children's development over the first 10 years of life;and determine factors affecting outcomes and rate of growth. It will also provide evidence on the impact of mild or unilateral hearing loss and the efficacy of early intervention. The findings will translate to improved population health by providing evidence on which to base clinical service delivery. The study will also assist future public health research in the field of hearing loss by means of making available a population-based cohort of early- and late-identified individuals with congenital hearing loss who can be followed longitudinally.            ,7745786;,"CHING, TERESA Y;","DONAHUE, AMY ",01/02/2006,01/31/2019,5 year old;9 year old;Acoustics;Activities of Daily Living;Address;Affect;Age;age effect;Age-Months;arm;Australia;base;Bilateral;Bilateral Hearing Loss;Child;Child Development;Child health care;Childhood;Clinical;Clinical Services;Cochlear implant procedure;Cognitive;cohort;cost;Data;Development;Diagnosis;Diagnostic;Dimensions;Early Intervention;Early treatment;Effectiveness;Environment;evidence base;follow-up;Funding;Future;Growth;Health Services Research;Healthcare;Hearing;Hearing Aids;hearing impairment;hearing screening;implantation;improved;Individual;Intervention;Investments;Knowledge;Laboratories;Language;Learning;Life;Link;literacy;Live Birth;Measurable;Measurement;Measures;Mental Health;Newborn Infant;Outcome;Outcome Measure;Performance;Phase;Population;population based;population health;Positioning Attribute;programs;prospective;Provider;public health relevance;public health research;Quality of life;Randomized;Randomized Controlled Trials;randomized trial;Reading;Regression Analysis;Research;Resources;Schools;service intervention;Services;Social Development;Software Tools;Source;Speech;standard care;systematic review;Time;Translating;Treatment Efficacy;Unilateral Hearing Loss;United States National Institutes of Health,Longitudinal outcomes of hearing-impaired children: early vs later intervention,8080,LCOM,Language and Communication Study Section,,,6,316532,
8631909,R01,DC,2,N,02/05/2014,02/05/2014,01/31/2015,173,R01DC008595,SCHOOLS OF MEDICINE,PA-11-260,2R01DC008595-06A1,NIDCD:380831\,Research Projects,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PORTLAND,UNITED STATES,OTOLARYNGOLOGY,03,096997515,US,OREGON HEALTH &SCIENCE UNIVERSITY,OR,972393098,PUBLIC HEALTH RELEVANCE: The proposed studies will advance our understanding of pattern formation and cell fate specification in the mammalian inner ear. This new knowledge will inform efforts to define gene- and cell-based strategies to restore auditory and vestibular function in the diseased or damaged inner ear.             ,1970856;,"BRIGANDE, JOHN VINCENT;","FREEMAN, NANCY ",02/01/2007,01/31/2019,Address;Alkaline Phosphatase;Anterior;Auditory;base;Base Sequence;Behavior;Binding (Molecular Function);Biological Models;Birds;cell fate specification;Cells;Chimeric Proteins;Complex;Data;Data Set;Daughter;daughter cell;design;Development;Duct (organ) structure;Ectoderm;Educational process of instructing;Embryo;Embryology;Endolymphatic duct;env Gene Products;Epithelial;Epithelial Cells;Epithelium;Equilibrium;Evaluation;Fiber Optics;Functional disorder;Funding;Gene Expression;Gene Mutation;Genes;Genetic;genetic manipulation;Genetic Recombination;Goals;Hair Cells;Hearing;Human;Image;in utero;in vivo;Individual;Intervention;Knowledge;Label;Laboratories;Labyrinth;Lateral;Left;Libraries;Locales;Location;mammalian embryology;Maps;Mediating;Membrane;Microinjections;Mitosis;Molecular;Morphogenesis;Mus;Neural Crest;Neural tube;Neuroepithelial;Neuroepithelial Cells;Neurons;novel;Oligonucleotides;Operative Surgical Procedures;Organ;Otic Vesicle;otoconia;Output;Pattern;Pattern Formation;placodal ectoderm;Population;precursor cell;progenitor;programs;public health relevance;recombinase;Recording of previous events;Regulation;relating to nervous system;Reporter;research study;restoration;Retroviridae;Sensory;Signal Transduction;Specific qualifier value;spiral ganglion;Staging;Stem cells;Structure;Supporting Cell;Techniques;Testing;Time;Tissues;Ultrasonography;Vestibular Hair Cells;Viral;Virus;Virus Receptors,Molecular embryology of the mammalian inner ear,8595,AUD,Auditory System Study Section,,A1,6,380831,
8630494,R01,EY,2,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY008247,SCHOOLS OF MEDICINE,PA-11-260,2R01EY008247-24A1,NEI:385000\,Research Projects,2014,NATIONAL EYE INSTITUTE,,PORTLAND,UNITED STATES,OPHTHALMOLOGY,03,096997515,US,OREGON HEALTH &SCIENCE UNIVERSITY,OR,972393098,"PUBLIC HEALTH RELEVANCE: Glaucoma remains a primary blinding disease. Increased intraocular pressure (IOP), caused by increased resistance to aqueous humor outflow, is the primary risk factor and reducing IOP is the only effective current treatment for all forms of glaucoma. Our recent studies have significantly advanced understanding of the molecular nature, organization and regulation of the outflow resistance. The proposed studies aimed at understanding how manipulations of the outflow resistance change its molecular organization and orientation will provide potent new tools to reduce the outflow resistance in glaucomatous individuals.            ",1859402;,"ACOTT, TED S;","CHIN, HEMIN R",08/01/1989,01/31/2018,Affect;Aqueous Humor;aqueous humor flow;Atomic Force Microscopy;base;Basement membrane;Binding (Molecular Function);Binding Proteins;Biology;Biomechanical compliance;Blindness;Cell Shape;Cells;Characteristics;chondroitin sulfate glycosaminoglycan;Chondroitin Sulfate Proteoglycan;Cytoskeleton;Disease;effective therapy;Endothelium;Extracellular Matrix;Extracellular Matrix Proteins;Eye;Family suidae;Funding;Glaucoma;Glycosaminoglycans;Homeostasis;Hour;Human;Human Characteristics;Hyaluronan;Immunohistochemistry;Individual;Lasers;Maps;Mechanics;Messenger RNA;Molecular;Molecular Probes;Molecular Structure;Nature;Pathway Analysis;Pathway interactions;Pattern;Perfusion;Persons;Physiologic Intraocular Pressure;Positioning Attribute;pressure;Process;Property;Protein Isoforms;Proteins;Proteoglycan;Proteomics;public health relevance;Regulation;Research;Research Personnel;Resistance;response;Risk Factors;RNA Interference;RNA Splicing;scaffold;Side;Stretching;Structure of sinus venosus of sclera;Testing;therapeutic target;tool;Trabecular meshwork structure;Trabeculectomy;versican;Work,Biology of trabecular response to laser trabeculoplasty,8247,BVS,,,A1,24,385000,
8648882,R01,EY,2,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY010420,SCHOOLS OF DENTISTRY/ORAL HYGN,PA-11-260,2R01EY010420-17A1,NEI:482081\,Research Projects,2014,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,BIOCHEMISTRY,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"PUBLIC HEALTH RELEVANCE: As phagocytes, retinal pigment epithelial cells function as a homeostatic regulator to maintain photoreceptor integrity and preserve visual function. Impairment of photoreceptor clearance contributes to age-related retinopathies characterized by sub-retinal deposits as well as lipofuscinosis ultimately leading to blindness. In these studies we will investigate a novel degradative pathway utilized by the retinal pigment epithelia to digest toxic debris and provide precursors for neuroprotection. This pathway called, LC3 associated phagocytosis (LAP), utilizes components of two different albeit interconnected digestive processes, autophagy and phagocytosis. Critical for degradation by this pathway is the protein melanoregulin (MREG). Understanding how the retinal pigment epithelia recognizes debris to be degraded by LAP and the role of MREG in this process will allow us to develop new therapeutic approaches to enhancing degradation in disease progression.            ",1883354;,"BOESZEBATTAGLIA, KATHLEEN;","NEUHOLD, LISA ",08/01/1994,01/31/2017,Acids;age related;Autophagocytosis;Autophagosome;base;Binding (Molecular Function);Biological Assay;Blindness;Cathepsins;Cell Death;Cell physiology;Cell Survival;Cells;Data;Degradation Pathway;Deposition;Digestion;Disease Progression;Docosahexaenoic Acids;Ensure;Event;Felis catus;Genes;Goals;Health;Homeostasis;Hybrids;hydroxy-aluminum polymer;Impairment;In Vitro;in vitro Model;in vivo;Ingestion;Light;Lipids;Lysosomes;Maintenance;Malondialdehyde;MAP1 Microtubule-Associated Protein;Mediating;Mitotic;Molecular;Mus;neuroprotectin D1;neuroprotection;novel;novel therapeutic intervention;Opsin;Oxidative Stress;Pathway interactions;Phagocytes;Phagocytosis;Phagosomes;Phospholipase A2;Phospholipids;Photoreceptors;Process;Property;Proteins;public health relevance;Recruitment Activity;Research;response;Retina;Retinal;Retinal Diseases;Role;Series;Sorting - Cell Movement;Stress;Structure of retinal pigment epithelium;Testing;Up-Regulation (Physiology);Vision;Work,Degradative Processes in RPE-photoreceptor renewal,10420,ZRG1,Special Emphasis Panel,,A1,17,482081,
8628471,R01,EY,2,N,02/01/2014,02/01/2014,01/31/2015,867,R01EY012509,,PA-11-260,2R01EY012509-14A1,NEI:500516\,Research Projects,2014,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,08,073826000,US,SCHEPENS EYE RESEARCH INSTITUTE,MA,02114,"PUBLIC HEALTH RELEVANCE: PVR (proliferative vitreoretinopathy) is the primary reason for failure to correct a rhegmatogenous retinal detachment (RRD) (Han, 2008;Ryan et al., 2006). PVR is typically treated surgically, which increases the risk of re-occurrence (Campochiaro, 2006;Charteris, 1998;Glaser et al., 1987);pharmacological treatment options do not exist, despite numerous attempts to develop them (Charteris, 1995). Generating drugs that prevent RRD patients from succumbing to PVR is a major unmet challenge.             ",1876929;,"KAZLAUSKAS, ANDRIUS;","NEUHOLD, LISA ",08/01/2000,01/31/2018,1-Phosphatidylinositol 3-Kinase;Acute;Address;Affect;Antioxidants;Apoptosis;Attenuated;Back;base;Binding (Molecular Function);Biochemical;Chronic;Complement;Disease;drug development;Enzymes;Event;experience;Failure (biologic function);Goals;Grant;Human;Laboratories;Learning;Mediating;Mediator of activation protein;member;Molecular;new therapeutic target;Oryctolagus cuniculus;Pathogenesis;Pathway interactions;Patients;PDGFRB gene;perpetrators;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor Receptor;Pre-Clinical Model;prevent;programs;Proliferative Vitreoretinopathy;Prophylactic treatment;public health relevance;Publishing;receptor;Recruitment Activity;Research;response;Retinal Detachment;Risk;senescence;Series;Signal Pathway;Signal Transduction;Testing;Therapeutic;therapeutic target;Work,PDGF and PVR,12509,DPVS,,,A1,14,500516,
8665612,R01,EY,2,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY012793,SCHOOLS OF MEDICINE,PA-11-260,2R01EY012793-14,NEI:496155\,Research Projects,2014,NATIONAL EYE INSTITUTE,,PROVIDENCE,UNITED STATES,NEUROSCIENCES,01,001785542,US,BROWN UNIVERSITY,RI,02912,"PUBLIC HEALTH RELEVANCE: This study explores how specialized cells and circuits in the eye are able to tell the brain how much light is in the environment. Excessive or abnormal signals from this system are involved in disturbances of the biological clock, light-induced pain, mood disorders and hormonal disturbances.            ",1898552;,"BERSON, DAVID M.;","GREENWELL, THOMAS ",02/07/2000,01/31/2019,Accounting;Amacrine Cells;Architecture;Automobile Driving;base;Behavior;Brain;cell type;Cells;Chronobiology Disorders;Circadian Rhythms;Code;Color;Confocal Microscopy;Data;Dendrites;Dyes;Employee Strikes;Environment;Equipment and supply inventories;Exhibits;Eye;feeding;Feeds;ganglion cell;Genetic Models;Glutamates;Goals;Hormonal;Imaging Techniques;Inner Plexiform Layer;Label;Light;light intensity;Link;luminance;melanopsin;Microscopy;Modeling;Monitor;Mood Disorders;Movement;Mus;neural circuit;Neurosecretory Systems;novel;Output;Pain;patch clamp;Perception;Photons;Photoreceptors;presynaptic;Property;public health relevance;receptive field;Reflex action;Regulation;Relative (related person);Reporting;Research;Resolution;response;Retinal;Retinal Cone;Retinal Ganglion Cells;Rods (Retina);Role;Signal Transduction;spatiotemporal;Structure;Synapses;System;Testing;tool;Transgenic Mice;transmission process;two-photon;Vertebrate Photoreceptors;Viral;Vision;Visual;Visual Cortex;Work,Structure and Function of Mammalian Ganglion Cells,12793,ZRG1,Special Emphasis Panel,,,14,496155,
8638317,R01,EY,2,N,02/07/2014,02/01/2014,01/31/2015,867,R01EY014167,SCHOOLS OF MEDICINE,PA-11-260,2R01EY014167-10A1,NEI:382500\,Research Projects,2014,NATIONAL EYE INSTITUTE,,MILWAUKEE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,937639060,US,MEDICAL COLLEGE OF WISCONSIN,WI,532263548,"PUBLIC HEALTH RELEVANCE: During both retinal development and in the maintenance of mature retinal neurons such as photoreceptor cells, various signaling pathways must be precisely regulated. In this proposal we describe studies primarily in zebrafish to understand the relationships between two signaling modules implicated both during development and in tissue homeostasis.            ",1952979;,"LINK, BRIAN A;","GREENWELL, THOMAS ",07/01/2002,01/31/2018,Address;Adult;Affect;Apical;Attention;base;Binding (Molecular Function);Cell Cycle Regulation;Cell physiology;Cells;Choroid;Data;Development;Endocytosis;Figs - dietary;Funding;Genetic;Goals;Homeostasis;Human;improved;Individual;loss of function;Maintenance;Mediating;Modification;mutant;Mutation;Nature;neuroepithelium;neurogenesis;Neurons;notch protein;Nuclear;Pathway interactions;Pattern;Phenotype;photoreceptor degeneration;Photoreceptors;Positioning Attribute;prevent;protein transport;public health relevance;Regulation;Research;research study;Retina;Retinal;retinal neuron;retinal progenitor cell;retinogenesis;Role;Series;Shapes;Signal Pathway;Signal Transduction;Stem cells;Structure of retinal pigment epithelium;System;Testing;Tissues;tool;trafficking;Transgenic Organisms;Zebrafish,Integrative Analyis of Vertebrate Retinal Lamination,14167,BVS,,,A1,10,382500,
8630603,R01,EY,2,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY017673,SCHOOLS OF MEDICINE,PA-11-260,2R01EY017673-06A1,NEI:300878\,Research Projects,2014,NATIONAL EYE INSTITUTE,,IOWA CITY,UNITED STATES,PHYSIOLOGY,02,062761671,US,UNIVERSITY OF IOWA,IA,52242,"PUBLIC HEALTH RELEVANCE: Glaucoma is a leading cause of irreversible blindness. Our research focuses on studies of pigmentary glaucoma, a common sub-type of glaucoma. The results will provide insight into the molecular pathways that lead to disease and may offer a pathway toward deployment of new glaucoma therapeutics.            ",8290427;,"ANDERSON, MICHAEL GARY;","CHIN, HEMIN R",07/01/2006,01/31/2018,Affect;Alleles;American;Animal Model;Animals;anterior chamber;Blindness;casein kinase II;Clinical;clinical practice;cohort;Collection;Data;Detection;Development;disability;Disease;disease-causing mutation;disorder risk;Dissection;empowered;Enrollment;Event;exome sequencing;Eye;Family;Family Study;Functional disorder;Genes;Genetic;genetic linkage analysis;genetic pedigree;genetic resource;Genotype;Glaucoma;Goals;high intraocular pressure;Human;Human Genetics;improved;Incidental Findings;Individual;Inherited;insight;Lead;Link;Melanins;Molecular;Molecular Analysis;mouse model;Mus;Mutation;Mutation Analysis;Open-Angle Glaucoma;Outcome;Pathway interactions;patient population;Patients;Pharmacologic Substance;Physiologic Intraocular Pressure;Physiological;pigment dispersion syndrome;Pigments;Population;Prevalence;Productivity;public health relevance;Quality of life;Recording of previous events;Research;research study;Resources;response;Risk Factors;Secondary to;Sequence Analysis;Shapes;Testing;Therapeutic;Trabecular meshwork structure;Treatment Factor;Variant;Vision;Visual,Genetic dissection of pigmentary glaucoma,17673,DPVS,,,A1,6,300878,
8631952,R01,EY,2,N,02/04/2014,12/01/2013,11/30/2014,867,R01EY018144,SCHOOLS OF MEDICINE,PA-11-260,2R01EY018144-06A1,NEI:346500\,Research Projects,2014,NATIONAL EYE INSTITUTE,,LOS ANGELES,UNITED STATES,PHYSIOLOGY,33,092530369,US,UNIVERSITY OF CALIFORNIA LOS ANGELES,CA,900952000,"PUBLIC HEALTH RELEVANCE: Vitamin A is essential for human vision, but excessive accumulation of vitamin A or chemicals derived from vitamin A is toxic. Both vitamin A deficiency and accumulation of toxic side products of vitamin A metabolism can cause blindness. Therefore, understanding how the eye obtains a sufficient but not excessive amount of vitamin A from the blood and how vitamin A uptake for vision is regulated will have a significant impact on efforts to preserve human vision.            ",8261194;,"SUN, HUI;","NEUHOLD, LISA ",04/01/2007,11/30/2017,Acute;Affect;Affinity;Aging;Animals;Binding (Molecular Function);Binding Proteins;Biological;Biological Process;blind;Blindness;Blood;Calcium;Calmodulin;Cell Maintenance;Cell Surface Receptors;cell type;Cells;Cellular biology;Chemicals;Complement;Complete Blindness;Complex;Cornea;design;Development;Disease;Esters;Evolution;Eye;Eye Development;fluorophore;Foundations;Gated Ion Channel;Goals;Human;innovation;insight;Knowledge;Light;Link;Lipoprotein Binding;Lipoproteins;Mediating;Metabolism;Methods;Modification;Molecular;Monitor;Mus;Nature;Organ;Organism;Pathway interactions;photoreceptor degeneration;Photoreceptors;Plasma;Play;prevent;Protein Binding;Proteins;public health relevance;Reagent;receptor;Regulation;Research;Retinal Pigments;Retinoids;retinol binding protein receptor;Retinol Binding Proteins;Role;Side;Site;Source;Structure;Structure of retinal pigment epithelium;Techniques;Time;Transmembrane Domain;Transmembrane Transport;Ulcer;uptake;Vision;visual cycle;Vitamin A;Vitamin A Deficiency,Molecular Mechanism of Vitamin A Uptake for Vision,18144,BVS,,,A1,6,346500,
8632393,R01,EY,2,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY021166,SCHOOL OF MEDICINE &DENTISTRY,PA-11-260,2R01EY021166-04,NEI:595969\,Research Projects,2014,NATIONAL EYE INSTITUTE,,ROCHESTER,UNITED STATES,OPHTHALMOLOGY,28,041294109,US,UNIVERSITY OF ROCHESTER,NY,14627,"PUBLIC HEALTH RELEVANCE:  Although recent research holds strong promise of developing biological therapies to treat the most common and debilitating forms of eye disease, such visual prostheses have not been examined in non-human primates.  This project will use an in vivo method for retinal physiology (Functional Adaptive-optics Cellular Imaging in the Living Eye or FACILE), to study the insertion of channelrhodopsin into retinal ganglion cells in order to treat blindness.  The studies will be carried out in non-human primates, which can be used to determine how channelrhodopsin can restore visual perception, especially high acuity foveal vision, which is critical to human perception.                ",1883369;,"MERIGAN, WILLIAM H;","GREENWELL, THOMAS ",02/01/2011,01/31/2019,adaptive optics;Area;base;Behavior;Biological Response Modifier Therapy;blind;Blinded;Blindness;Bypass;Calcium;calcium indicator;Cell physiology;Cells;cellular imaging;Contrast Sensitivity;Data;design;Discrimination (Psychology);driving behavior;Effectiveness;Exposure to;Eye;Eye diseases;Feasibility Studies;fovea centralis;functional restoration;ganglion cell;Human;Image;in vivo;Individual;intravitreal injection;Lesion;Life;Light;Location;luminance;Macaca;Maps;Measurement;Measures;Mediating;Methods;Modeling;Monkeys;Motion;Mus;nonhuman primate;Ocular Prosthesis;optic imaging;Optics;optogenetics;Pattern;Perception;Performance;Photophobia;Photoreceptors;Photosensitivity;Phototoxicity;Physiology;Primates;Property;Prosthesis;Psychophysics;public health relevance;Radial;receptive field;Research;research study;Resolution;response;Retina;Retinal;Retinal Cone;Retinal Degeneration;Retinal Ganglion Cells;retinal neuron;Specific qualifier value;Spottings;Stimulus;Structure of retinal pigment epithelium;Testing;vector;Vision;Visual;Visual Acuity;Visual Perception;visual performance;Visual system structure,Feasibility of an Optogenetic Prosthesis for the Primate Eye,21166,BNVT,,,,4,595969,
8628913,R01,GM,2,N,02/04/2014,02/04/2014,01/31/2015,859,R01GM050895,SCHOOLS OF ARTS AND SCIENCES,PA-11-260,2R01GM050895-17A1,NIGMS:384217\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,BIOLOGY,07,001425594,US,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,MA,02139,"PUBLIC HEALTH RELEVANCE: Relevance Mobile genetic elements and horizontal gene transfer in microbes contribute significantly to pathogenesis and the spread of antibiotic resistances. Despite their importance, mechanisms controlling a common type of mobile element and the identities and roles of host genes involved in their spread are poorly understood, especially in Gram positive bacterial pathogens. This project is directly related to mechanisms controlling the spread of antibiotic resistances and pathogenic determinants.            ",1859694;,"GROSSMAN, ALAN D;","REDDY, MICHAEL K.",05/01/1994,01/31/2018,Affect;Antibiotic Resistance;Autonomous Replication;Bacillus (bacterium);Bacillus subtilis;Bacteria;Bacterial Genome;Bacteriophages;base;Beryllium;Biological;Biology;cell killing;Cell physiology;Cells;Coupling;Crowding;DNA;DNA Damage;driving force;Drug resistance;Elements;Environment;Evolution;Excision;Exclusion;Family;Frequencies (time pattern);Gene Expression;Gene Transfer;Genes;Genetic;Genome;Goals;Gram-Positive Bacteria;Growth;helicase;Homologous Gene;Horizontal Gene Transfer;Human;Indium;Insertion Mutation;insight;intercellular communication;Interleukin Receptor;Knowledge;Life Cycle Stages;Mediating;Metabolism;Microbe;Mobile Genetic Elements;Multi-Drug Resistance;Mutagenesis;mutant;next generation sequencing;overexpression;Partner in relationship;pathogen;Pathogenesis;Phenotype;Plasmids;Play;Population;Prevalence;Property;Proteins;public health relevance;Replication Origin;Role;Single-Stranded DNA;Site;SOS Response (Genetics);Symbiosis;Testing;Virus,"Cell-Cell Signaling, Gene Expression, and Horizontal Gene Transfer in Bacillus",50895,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,A1,17,384217,
8652073,R42,MH,2,N,02/03/2014,02/03/2014,01/31/2015,242,R42MH095516,,PA-13-089,2R42MH095516-02,NIMH:498741\,SBIR-STTR,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,SANTA FE,UNITED STATES,,03,965494904,US,"ACCOUNTABILITY SOLUTIONS, INC.",NM,87505,"PUBLIC HEALTH RELEVANCE: This project will complete development and evaluate usability and effectiveness of the Wraparound Team Monitoring System (Wrap-TMS), a web-based, electronic behavioral health information system (EBHIS) for the most widespead care coordination model in children's behavioral health, the wraparound process. Wrap-TMS will provide an important health information technology (HIT) resource to hundreds of wraparound sites nationally, and reinforce efficiency, effective teamwork, model fidelity, decision making, use of evidence-based practices, and positive outcomes. The rigorous randomized control study will provide important information for the children's mental health field about the effects of EBHIS on implementation and outcomes. The project will serve as an important part of the effort to bridge the research to practice gap in children's behavioral health, be a critical component of the federal emphasis on better coordination of care for complex populations, and facilitate needed research on care coordination for youths with serious emotional and behavioral disorders.            ",6719659;,"BRUNS, ERIC J.;","HAIM, ADAM ",09/15/2011,01/31/2016,Abnormal coordination;Accountability;base;Behavior;Behavior Disorders;behavioral health;Businesses;Caring;Child;Child Mental Health;Childhood;Clinical;Clinical assessments;clinical decision-making;Clinical Services;commercialization;Community Practice;Complex;cost;Data;Data Element;Decision Making;Development;Diagnosis;Diagnostic Services;Drops;Educational Curriculum;Effectiveness;Electronics;Elements;Emotional;Emotional disorder;Enrollment;Evaluation;evidence base;Evidence based practice;Family;Family member;Federal Government;Feedback;flexibility;Funding;Goals;Health;Health Information System;health information technology;Health Resources;Healthcare;improved;Information Management;interest;Internet;interoperability;Lead;Life;Light;Managed Care;Manuals;Marketing;meetings;member;Mental Health;Modeling;Monitor;Online Systems;Outcome;Perception;Phase;Population;Process;programs;Provider;Psychometrics;public health relevance;quality assurance;Randomized;Randomized Controlled Trials;Recommendation;Reporting;Research;research and development;Research Infrastructure;research to practice;Resources;satisfaction;Schedule;Schools;Services;Site;Small Business Technology Transfer Research;Specific qualifier value;standardize measure;Stream;success;Supervision;Surveys;System;Tablets;Technology;Technology Transfer;Telephone;Testing;touchscreen;Training;usability;Validity and Reliability;Work;Youth,"Development, Usability Testing, and Effectiveness Evaluation of the Wraparou",95516,ZRG1,Special Emphasis Panel,,,2,498741,
8648805,R44,AI,2,N,02/06/2014,02/06/2014,01/31/2015,855,R44AI056785,,PA-13-088,2R44AI056785-04,NIAID:885321\,SBIR-STTR,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SANTA CLARA,UNITED STATES,,17,603207106,US,"ID FISH TECHNOLOGY, INC.",CA,95054,"PUBLIC HEALTH RELEVANCE: Malaria is a serious, often fatal, parasitic disease caused by infection of the red blood cells with protozoan parasites of the Plasmodium species, P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. According to the latest WHO estimates, there were about 219 million cases of malaria in 2010 and an estimated 660 000 deaths. 90% of deaths occur in Africa, the most affected continent. In Africa a child dies every minute from malaria. The six highest burden countries in the WHO African region (in order of estimated number of cases) are: Nigeria, Democratic Republic of the Congo, United Republic of Tanzania, Uganda, Mozambique and Cote d'Ivoire. These six countries account for an estimated 103 million (or 47%) of malaria cases. In South East Asia, the second most affected region in the world, India has the highest malaria burden (with an estimated 24 million cases per year), followed by Indonesia and Myanmar.1 Even though malaria is a frequently encountered disease in many developing countries, it is difficult to make the right diagnosis relying on clinicl signs only. Drug selection for the treatment of malaria depends on species of malaria present. Delayed or missed diagnosis of falciparum malaria increases the risk of complicated or severe disease, which may be fatal vulnerable populations. P. falciparum from much of the world is largely chloroquine resistant and thus the standard treatment for P. vivax cannot be used. To prevent unnecessary anti-malarial treatment and future drug-resistance strains of malaria parasites, it is important to confirm clinical suspicious with a good laboratory test. In light of he changing drug policies of many African countries, including Tanzania and Kenya, where the expensive artemisinin combination therapy (ACT) drugs are prescribed as first-line treatment, a good laboratory confirmation will also have an impact on the economics. The Giemsa stain is helpful. However, when parasite levels are very low, or in mixed infections, the information obtained by examination of Giemsa stained smear by microscopy is limited, and in some cases, biased, by the inability to devote the necessary amount of time to the examination of blood smears. PCR would help. Unfortunately it is time-consuming and expensive. Thus, FISH Tests for detection of Plasmodium and for differentiation of P. falciparum and P. vivax in air-dried blood smears has potential in the rapid diagnosis of this disease. Advantages: P-Genus and PFV FISH Assays 1. P- Genus FISH Assay detects all five species of Plasmodium, P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. Therefore the Genus FISH assay can be used for screening. Any sample that is positive can be tested further if necessary with the PFV- FISH Assay to determine whether the infection is due to P. falciparum, P. vivax, both or neither. 2. Specificity of the assays is equivalent to the amplified assays. 3. Sensitivity of te assays when performed by a typical microscopist should be the same as or better than Giemsa stained smear performed by an expert microscopist'4. Ability to perform the tests on an air-dried whole blood smear. 5. Results can be obtained in two hours or less would be valuable. 6. Provides parasite morphology as the Giemsa stained smear. 7. Easy to perform. 8. Low Cost.            ",8738223;,"SHAH, JYOTSNA S;","JOY, DEIRDRE A.",07/01/2003,01/31/2015,Accounting;Affect;Africa;African;Air;Antimalarials;artemisinine;Artemisinins;base;Biological Assay;Blood;Blood specimen;Cessation of life;Child;Chloroquine resistance;Clinical;Clinical Research;Combined Modality Therapy;cost;Country;Data Analyses;Democratic Republic of the Congo;Detection;Developing Countries;Diagnosis;diagnosis standard;Disease;DNA Probes;Drug Prescriptions;Drug resistance;Economics;Erythrocytes;Falciparum Malaria;Far East;fluorescence microscope;Fluorescent in Situ Hybridization;Future;Giemsa stain;Gold;Grant;Hour;India;Indonesia;Infection;Ivory Coast;Kenya;Label;Laboratories;Left;Life;Light;Light Microscope;Malaria;Marketing;Microscopy;Morphology;Mozambique;Nigeria;Parasites;Parasitic Diseases;Patients;Peru;Pharmaceutical Preparations;Phase;Plasmodium;Plasmodium falciparum;Policies;Preparation;prevent;Principal Investigator;Process;programs;Protocols documentation;public health relevance;rapid diagnosis;Reading;Reagent;Reporting;Reproducibility;Research Infrastructure;resistant strain;Ribosomal RNA;Risk;sample fixation;Sampling;screening;Selection for Treatments;Site;Small Business Innovation Research Grant;Specificity;Staging;standard care;Symptoms;Tanzania;Techniques;Testing;Time;Uganda;validation studies;Vulnerable Populations;Whole Blood;Writing,Plasmodium Genus and PFV Fluorescent In Situ Hybridization (FISH) Assay Kit for d,56785,ZRG1,Special Emphasis Panel,,,4,885321,
8731737,R44,AI,2,N,02/07/2014,02/07/2014,01/31/2015,855,R44AI097001,,PA-13-234,2R44AI097001-02A1,NIAID:1000000\,SBIR-STTR,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PORTLAND,UNITED STATES,,03,016504083,US,SEDIA BIOSCIENCES CORPORATION,OR,972301049,"PUBLIC HEALTH RELEVANCE: This project will expand the applicability of and fully develop a commercially viable assay for an HIV antibody avidity assay (the Sedia HIV-1 LAg-Avidity EIA) and establish its superiority over current methods for identifying recent HIV-1 infections. Identification of recent infections enables 1) measurement of new HIV-1 infections in a population to monitor the epidemic spread and 2) diagnosis of new HIV-1 infection in individuals allowing the identification and targeting of hyper-infectious early cases who are at greatest risk of transmitting HIV to sexual partners. The assay will be used to generate improved estimates of HIV incidence in the U.S. and internationally, as well as to improve public health efforts and optimize use of limited resources by targeting treatment, follow-up and contact tracing of individuals at highest risk of HIV transmission.            ",10784070;,"MINK, RONALD WILLIAM;","SHARMA, USHA K.",07/01/2011,01/31/2015,Acquired Immunodeficiency Syndrome;Acute;AIDS/HIV problem;Antibody Avidity;Antigens;Applications Grants;Avidity;base;Biological Assay;Blood;Blood specimen;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinical;clinical application;clinical care;clinical Diagnosis;Clinical Management;Clinical Trials;cohort;Cold Chains;commercialization;Complex;Consensus;Contact Tracing;Counseling;Critical Pathways;Data;Developing Countries;Diagnosis;Diagnostic;Disease;Drug Formulations;Early Intervention;Effectiveness of Interventions;Epidemic;Epidemiologist;Epidemiology;Evaluation;Evaluation Research;FDA approved;field study;follow-up;Funding;Health Resources;high risk;HIV;HIV Antibodies;HIV Infections;HIV-1;Housing;Human immunodeficiency virus test;improved;Incidence;Individual;Infection;Information Systems;Intervention;Laboratories;Laboratory Study;Licensing;Liquid substance;Literature;Marketing;Measurement;Measures;meetings;Methods;Molecular Conformation;Monitor;novel;Performance;Persons;Phase;Plasma;Population;pre-clinical;Prevalence;Prevention;Process;Product Approvals;Production;programs;Protocols documentation;public health medicine (field);public health relevance;Reproducibility;Research;research and development;Research Personnel;Resources;response;Risk;scale up;Series;Serum;Sexual Partners;Small Business Innovation Research Grant;Source;Specimen;Spottings;Stimulus;success;Surveillance Program;System;Technology;Testing;tool;transmission process;Validation;Work,Novel Single Well Avidity EIA to Determine Recency of HIV-1 Infections,97001,ZRG1,Special Emphasis Panel,,A1,2,1000000,
8795905,F31,GM,3,N,02/03/2014,01/11/2011,01/10/2015,859,F31GM095230,,PA-09-209,3F31GM095230-04S1,NIGMS:42232\,"Training, Individual",2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATHENS,UNITED STATES,,10,004315578,US,UNIVERSITY OF GEORGIA,GA,306025016,"Coenzyme B12 is only synthesized by prokaryotes, including many pathogens, and it is essential to the survival of animals, including humans. A better understanding of the biochemistry of coenzyme B12 biosynthesis will facilitate the design of antimicrobials that could be used to target disease-causing bacteria. In collaboration with others, our laboratory used knowledge gained from the studies of coenzyme B12 synthesis in our fight against cancer. A multifaceted approach will be applied to learn more about the last step of the pathway, which, in Salmonella enterica, it may occur outside the cell.",9399433;,"TAVARES, NORBERT K;","GAILLARD, SHAWN R.",01/11/2011,01/10/2015,Acids;Active Sites;Address;Anabolism;Animals;antimicrobial;Archaea;Area;Award;Bacteria;base;Binding (Molecular Function);Biochemistry;Bioinformatics;Biological Assay;C-terminal;Calorimetry;Cell membrane;Cells;chemical property;Chemical Structure;Chemicals;Chemistry;cobamamide;Coenzyme M;Coenzymes;Collaborations;Complex;crosslink;Crystallization;design;Disease;Engineering;Enzymes;fight against;Fluorescence;Genetic;Genetic Complementation Test;Goals;Human;Imagination;improved;in vitro activity;in vitro Assay;in vivo;inhibitor/antagonist;insight;interdisciplinary approach;Ions;Kinetics;Knowledge;Laboratories;LacZ Genes;Learning;Life;Location;Malignant Neoplasms;Membrane;Membrane Proteins;Metabolism;Microscopy;Molecular;Multiprotein Complexes;N-terminal;Nobel Prize;pathogen;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Physiological;Prokaryotic Cells;Property;Proteins;Reaction;Reporter;Research;Salmonella enterica;Scientist;small molecule;Societies;Structural Biologist;Testing;TEV protease;Time;Titrations;Transferase;Ultracentrifugation;Variant;Western Blotting;Work,Membrane-associated Steps in Coenzyme B12 Biosynthesis,95230,ZRG1,Special Emphasis Panel,,S1,4,42232,
8796092,P01,GM,3,N,02/05/2014,05/01/2013,04/30/2014,859,P01GM099568,SCHOOLS OF PUBLIC HEALTH,PAR-10-266,3P01GM099568-02S2,NIGMS:51915\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,BIOSTATISTICS &OTHER MATH SCI,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472,  This program project grant will support five highly successful statistical and quantitative geneticists to work synergistically on the development and application of statistical methodology for the interpretation of large- scale genomic data and the characterization of the genetic architecture of complex traits.        Significance: 2    Investigator(s): 1    Innovation: 2    Approach: 2    Environment: 1            ,1863228;,"WEIR, BRUCE S.;","ECKSTRAND, IRENE A.",06/05/2012,04/30/2017,Alleles;Architecture;Biology;Biometry;cohort;Complex;Data;Detection;Development;Environment;Gene Expression;Genes;Genetic;Genomics;Head;Human;Individual;innovation;Institutes;Investigation;method development;Methodology;Methods;peripheral blood;Phenotype;Postdoctoral Fellow;professor;Program Research Project Grants;programs;Quantitative Genetics;Queensland;Research;Research Personnel;Resolution;statistics;trait;Universities;Variant;Washington;Work,Statistical and quantitative genetics,99568,ZRG1,Special Emphasis Panel,,S2,2,51915,
8788970,P30,CA,3,N,02/06/2014,12/01/2013,11/30/2014,397,P30CA014089,SCHOOLS OF MEDICINE,,3P30CA014089-39S1,NCI:75000\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,37,072933393,US,UNIVERSITY OF SOUTHERN CALIFORNIA,CA,900899235,"RELEVANCE: The USC Norris Comprehensive Cancer Center provides the infrastructure and resources to facilitate and foster translational research for the development of more effective prevention, diagnosis, treatment of cancer.",1902433;,"GRUBER, STEPHEN B;","SILKENSEN, SHANNON M.",12/01/1996,11/30/2015,anticancer research;Area;California;Cancer Center;Cancer Center Support Grant;Cancer Control Research;cancer epidemiology;Cancer Hospital;cancer therapy;Country;Development;Developmental Therapeutics Program;Diagnosis;Direct Costs;Epigenetic Process;Evaluation;Fostering;Funding;Grant;Head;innovation;Leadership;leukemia/lymphoma;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;member;Molecular Genetics;Peer Review;Pilot Projects;population based;Prevention;Prevention education;programs;Recruitment Activity;Regulation;Research;research and development;Research Infrastructure;Research Peer Review;Research Personnel;Resource Sharing;Resources;Translating;Translational Research;tumor microenvironment;Universities;Urogenital Cancer;USC/Norris Comprehensive Cancer Center and Hospital;Wages;Woman,USC Norris Comprehensive Cancer Center (CORE) Support,14089,NCI,Subcommittee B - Comprehensiveness,,S1,39,75000,
8788976,P30,CA,3,N,02/05/2014,01/21/2014,11/30/2014,397,P30CA016086,SCHOOLS OF MEDICINE,,3P30CA016086-38S1,NCI:67500\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,608195277,US,UNIV OF NORTH CAROLINA CHAPEL HILL,NC,27599,,6477317;,"EARP, HENRY SHELTON;","SHAFIK, HASNAA ",06/01/1997,11/30/2015,anticancer research;Area;Basic Science;Bioinformatics;Budgets;cancer care;Cancer Center;cancer genetics;Cancer Hospital;cancer therapy;Clinical;clinical epidemiology;Clinical Oncology;Clinical Sciences;Communication;Development;Discipline;Drug Delivery Systems;drug discovery;Early Diagnosis;Equipment;Evaluation;Event;Extramural Activities;Faculty;Fostering;Funding;Genetic Research;Grant;Investments;Journals;Leadership;malignant breast neoplasm;Malignant Neoplasms;member;Minority;Molecular Epidemiology;multidisciplinary;National Cancer Institute;North Carolina;Patient Care;Pharmacologic Substance;Population;Population Sciences;Prevention;Productivity;programs;Publications;Recruitment Activity;Research;Research Personnel;Resource Sharing;Rosa;Science;Scientist;Site;Structure;survivorship;The Cancer Genome Atlas;Therapy Clinical Trials;Training;Translational Research;UNC Lineberger Comprehensive Cancer Center;Universities,Cancer Center Core Support Grant,16086,NCI,Subcommittee B - Comprehensiveness,,S1,38,67500,
8790783,P30,CA,3,N,02/06/2014,02/05/2014,01/31/2015,397,P30CA046934,SCHOOLS OF MEDICINE,PAR-11-005,3P30CA046934-26S1,NCI:67500\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,NONE,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE: The NCl-designated Cancer Centers are the centerpiece of the national effort to reduce morbidity and mortality from cancer. As the only NCl-designated Cancer Center in the State of Colorado, the UCCC innovates in the development of more effective approaches to prevention, diagnosis, and therapy of cancer and the deployment of such therapies throughout the state. This application requests renewal of the UCCC's NCl-designated status so we may continue to fight cancer for our community, region, and beyond.",6182841;,"THEODORESCU, DAN;","CIOLINO, HENRY P.",08/06/1997,01/31/2017,Animals;anticancer research;base;Biological Markers;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Cancer stem cell;cancer therapy;Caring;Catchment Area;Cellular biology;Clinical;Clinical Research;Clinical Sciences;Colorado;Communities;Comprehensive Cancer Center;cost;Development;Developmental Therapeutics Program;Diagnosis;DNA Sequence Rearrangement;drug development;Epidermal Growth Factor Receptor;fighting;follower of religion Jewish;Funding;Gap Junctions;Grant;Growth;Head Cancer;Health;health disparity;Health system;Hormones;Hospitals;Human;Image;improved;innovation;Institutes;Institution;Investments;Lead;Malignant neoplasm of lung;Malignant Neoplasms;Marshal;Medical center;medical schools;Medicine;member;Mission;molecular oncology;Morbidity - disease rate;Mortality Vital Statistics;Neck Cancer;Neoplasm Metastasis;Newly Diagnosed;next generation;outreach program;Pathology;Patients;Pediatric Hospitals;Peer Review;Physicians;Population;prevent;Prevention;Prevention approach;Program Development;programs;Publications;Request for Applications;Research;research facility;Research Personnel;Research Project Grants;Resource Development;Resource Sharing;Resources;Role;Scientist;Seeds;Strategic Planning;Structure;survivorship;Therapy Clinical Trials;Training;Translational Research;tumor microenvironment;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Vision;Wyoming,Cancer Center Support Grant,46934,NCI,Subcommittee B - Comprehensiveness,,S1,26,67500,
8791739,R01,CA,3,N,02/04/2014,01/01/2014,12/31/2014,077,R01CA129771,SCHOOLS OF PUBLIC HEALTH,PA-07-070,3R01CA129771-05S1,OD:384823\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,COLUMBUS,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,03,832127323,US,OHIO STATE UNIVERSITY,OH,43210,"PUBLIC HEALTH RELEVANCE:       The proposed study examines the efficacy of a scientifically valid tobacco cessation intervention with Ohio Appalachian community residents, a group known to have increased rates of tobacco-attributable diseases. We will also examine social and contextual factors associated with tobacco cessation. Finally, in selected neighborhoods and communities, we will characterize pro- and anti-tobacco features that may influence cessation, using a novel geographical information system to describe patterns of exposure.",1861789;,"WEWERS, MARY ELLEN;","AUGUSTSON, ERIK ",01/01/2010,12/31/2014,Abstinence;Adult;Aftercare;American;Appalachian Region;Behavior;Bladder;Cervix Uteri;Cessation of life;Chronic Obstructive Airway Disease;cigarette smoking;Clinical Trials Design;Communities;contextual factors;Control Groups;Coronary Arteriosclerosis;Cotinine;Counseling;County;Data;Disadvantaged;Disease;Economic Burden;Esophagus;Health;Health Care Costs;High Prevalence;Individual;Information Systems;Intervention;intervention effect;Interview;Kidney;Larynx;Logistic Regressions;malignant mouth neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;Morbidity - disease rate;Mortality Vital Statistics;Neighborhoods;novel;Nurses;Ohio;Pancreas;Participant;Patient Self-Report;Pattern;Pharyngeal structure;Population;premature;Productivity;public health medicine (field);quitline;Randomized;randomized trial;Research;Risk;Risk Factors;Sampling;Services;Smoker;Smoking;smoking cessation;social;Social Network;social norm;Societal Factors;success;Telephone;Time;Tobacco;tobacco abstinence;tobacco exposure;Tobacco use;Tobacco Use Cessation;Training;trend;two-arm study;Uninsured;United States;Validation;Vulnerable Populations;Withholding Treatment,Tobacco cessation interventions with Ohio Appalachian smokers,129771,CLHP,Community-Level Health Promotion Study Section,,S1,5,384823,
8774385,R01,DA,3,N,02/04/2014,01/01/2014,12/31/2014,279,R01DA030420,SCHOOLS OF MEDICINE,PA-12-100,3R01DA030420-03S1,NIDA:115995\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,03,043207562,US,YALE UNIVERSITY,CT,065208047, This project is directly relevant to public health since the results will be used provide information needed to control the epidemic of hepatitis C virus transmission among injection drug users.            ,1893992;,"HEIMER, ROBERT;","LAO, GUIFANG ",01/01/2014,12/31/2014,Acids;American;Amphetamines;Anthropology;base;Beer;Biological Assay;Blood;Charge;Chemicals;Chronic Hepatitis C;Cirrhosis;Country;Crack Cocaine;Data;design;Detergents;Development;Disinfectants;Drug Compounding;Effectiveness;Epidemic;Epidemiologist;Epidemiology;Equipment;experience;Exposure to;Genotype;Harm Reduction;Hepatitis C;Hepatitis C Prevalence;Hepatitis C Transmission;Hepatitis C virus;Heroin;high risk;HIV;HIV Infections;HIV Seroprevalence;Hospitals;Household;In Vitro;in vitro Assay;Incidence;Individual;Infection;Infectious hepatitides;Injecting drug user;injection drug use;Injection of therapeutic agent;innovation;Laboratories;Location;Medical;Methods;Morbidity - disease rate;Mortality Vital Statistics;Needles;Needlestick Injuries;novel;Particulate;Perchlorates;Pharmaceutical Preparations;Population;prevent;Prevention;Prevention program;Prevention strategy;Primary carcinoma of the liver cells;programs;Protocols documentation;public health medicine (field);Research;Research Personnel;Rice;Risk;Seroprevalences;Sodium;Solutions;Syringes;System;Temperature;Testing;Thailand;Time;Translational Research;transmission process;Ukraine;United States;Virion;virology;Virus;Water;Wine;Work,Parenteral HCV Transmission: Assessing Risks and Prevention Strategies in vitro,30420,,,,S1,3,115995,
8790797,R01,DA,3,N,02/03/2014,07/01/2013,06/30/2014,279,R01DA031944,SCHOOLS OF MEDICINE,PA-10-067,3R01DA031944-03S1,NIDA:94668\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,LITTLE ROCK,UNITED STATES,ANESTHESIOLOGY,02,122452563,US,UNIV OF ARKANSAS FOR MED SCIS,AR,72205,"This project is designed to conduct the first studies in humans of an innovative, new antibody medicine designed to block methamphetamine effects while patients undergo the long process of recovery from methamphetamine addiction. In this project, an anti-methamphetamine monoclonal antibody will be tested to determine its safety and its potential for effectiveness. This innovative medication: i) could provide an essential missing component of standard drug-abuse treatment programs;ii) has the potential to reduce the devastating behavioral and societal effects of methamphetamine abuse;and iii) therefore should improve public health.",2084622;,"GENTRY, W BROOKS;","CHIANG, NORA ",07/15/2011,06/30/2014,Acute;addiction;Affinity;American;Amphetamines;Antibodies;base;Behavior Therapy;Behavioral;Binding (Molecular Function);Biological Assay;blind;Blood;Brain;Chronic;Clinical;Clinical Treatment;Communities;Compliance behavior;cost;Data;Data Collection;design;Development;Development Plans;disorder later incidence prevention;dopamine transporter;Dose;Drug Kinetics;drug standard;Economics;Effectiveness;efficacy trial;Engineering;experience;follow-up;Funding;Future;Goals;Grant;Human;human study;Immune;improved;in vivo;Industry;innovation;Investigational Drugs;Investigational New Drug Application;Knowledge;manufacturing process;Mediating;Medical;Medicine;meetings;Methamphetamine;methamphetamine abuse;Methamphetamine dependence;Monoclonal Antibodies;Mus;Neurotransmitters;non-drug;novel;novel therapeutics;Outcome;Overdose;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Phencyclidine;Physiological;Placebo Control;pre-clinical;pre-clinical research;Preparation;prevent;Probability;Process;Production;programs;Property;public health medicine (field);Quality Control;Rattus;recidivism;Recovery;Regimen;Relapse;Research;Research Personnel;response;Safety;safety study;Sampling;Site;small molecule;social;stability testing;Testing;Therapeutic;Time;treatment program;United States Food and Drug Administration;Validation;Vision;Work,First Human Studies of a Chimeric Anti-Methamphetamine Monoclonal Antibody,31944,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,S1,3,94668,
8797585,R01,ES,3,N,02/07/2014,02/07/2014,01/31/2015,113,R01ES019155,,PA-10-067,3R01ES019155-03S1,NIEHS:85730\,Research Projects,2014,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,WATERTOWN,UNITED STATES,,05,153914080,US,"NEW ENGLAND RESEARCH INSTITUTES, INC.",MA,024724515,"PUBLIC HEALTH RELEVANCE: This study uses extant data collected from 534 children who were aged 6-10 years at baseline and followed for 5 years as part of the NIH-funded New England Children's Amalgam Trial to test novel hypotheses that exposure to composite dental materials is associated with the following bisphenol A (BPA) related health outcomes: weight gain (body mass index, % body fat, and lean body mass), behavioral problems, neuropsychological function, and an exploratory study (n=66) of immune function. Associations will be examined with total exposure to composite restorations (e.g., intent to treat analysis of randomized treatment group) as well as with more specific dose-response models by type of materials (composite restorations, compomer restorations, and flowable composites as preventive restorations or sealants). Biomarker data (urinary BPA) will be collected from a new sample of 110 children treated with the same composite from the Trial's urban clinical location to determine urinary BPA exposure effects of these dental materials.",9220478;,"MASEREJIAN, NANCY NAIRI;","GRAY, KIMBERLY A.",04/01/2011,01/31/2015,14 year old;Accounting;Adolescence;Age;age group;aged;Animal Experiments;Area;Attention;base;Behavior;Behavioral;Biological Markers;Bis-DMA;bisphenol A;Bisphenol A-Glycidyl Methacrylate;Body Composition;Body fat;Body mass index;Body Weight;boys;chemical release;Chemicals;Child;Child Development;Chronic;Chronic Disease;Clinic;Clinical;Clinical Trials;Clinical Trials Design;cohort;Compomers;Composite Dental Resin;composite restoration;Conduct Clinical Trials;Country;cytotoxicity;Data;Dental;Dental Amalgam;Dental caries;Dental Materials;Dentistry;Development;Dose;Emotional;Endocrine Disruptors;Endocrinology;Environment;Epidemiology;Epoxy Resins;Ethics;experience;Exposure to;flowable hybrid composite;follow-up;Functional disorder;Funding;girls;Health;Human;human population study;immune function;Immunology;In Vitro;in vivo;indexing;Individual;innovation;Kidney;Knowledge;Life;Location;Longevity;Measurable;Measures;Memory;Mental Health;Methodology;Modeling;monomer;National Institute of Dental and Craniofacial Research;neglect;neuropsychological;Neuropsychological Tests;Neuropsychology;New England;novel;Obesity;Oral;Outcome;Pediatric Dentistry;Persons;physical conditioning;Plant Resins;Population Group;Preventive;Problem behavior;Propane;prospective;psychosocial;Puberty;Randomized;Randomized Clinical Trials;Randomized Controlled Trials;repaired;Research;research study;response;restoration;restorative dentistry;restorative material;Safety;Sampling;skills;Source;Symptoms;System;Testing;Time;tooth filling;tooth surface;Toxicology;United States National Institutes of Health;urinary;Visit;visual motor;Weight;Weight Gain,Health Effects of Dental Composites in Children,19155,NAME,"Neurological, Aging and Musculoskeletal Epidemiology Study Section",,S1,3,85730,
8729150,R01,GM,3,N,02/06/2014,07/01/2013,06/30/2014,859,R01GM048533,SCHOOLS OF DENTISTRY/ORAL HYGN,PA-12-149,3R01GM048533-21S1,NIGMS:37106\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,BIOCHEMISTRY,07,604483045,US,BOSTON UNIVERSITY MEDICAL CAMPUS,MA,021182340,"PUBLIC HEALTH RELEVANCE: There is a growing need for safe and effective antifungal agents that stems from the rapidly increasing population of immune-compromised patients. Because human cells do not possess the machinery needed to construct cell walls, the process of wall construction in fungal pathogens provides an attractive target for novel therapeutics. Proposed studies are likely to reveal suitable molecular targets for the development of antifungal agents that display selective toxicity against fungal cells.            ",1876792;,"LEVIN, DAVID E.;","REDDY, MICHAEL K.",09/30/1992,06/30/2014,Antifungal Agents;Attention;Binding (Molecular Function);Caffeine;Cell Cycle Progression;Cell surface;Cell Wall;Cells;Chromatin Remodeling Factor;Code;Complex;Data;Development;DNA Damage;DNA damage checkpoint;DNA-Directed RNA Polymerase;Drug Targeting;Funding;G2/M Transition;Gene Targeting;Genes;Genetic;Genetic Transcription;Glycerol;Growth;Guanosine Triphosphate Phosphohydrolases;Human;hydroxyurea;Immune;insight;Kinetochores;Knowledge;Maintenance;Malignant Neoplasms;MAP Kinase Gene;MAP Kinase Modules;MAPK7 gene;Mass Spectrum Analysis;Mediating;Mitogen-Activated Protein Kinases;Modification;Molecular Target;Morphogenesis;mutant;Mutation;Nature;new therapeutic target;novel;Orthologous Gene;Osmotic Shocks;pathogen;Pathway interactions;Patients;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Population;pressure;Process;programs;Promotor (Genetics);Protein Kinase;Protein Kinase C;Proteins;public health relevance;Regulation;Regulatory Pathway;Reporting;Research;research study;response;Role;Serine;Signal Pathway;Signal Transduction;stem;Stress;stressor;Testing;Toxic effect;Transcription Elongation;transcription factor;yeast protein;Yeasts,PA-12-149:Diversity Supplement for 5 R01 GM048533-21,48533,,,,S1,21,37106,
8729189,R01,GM,3,N,02/06/2014,12/01/2013,11/30/2014,859,R01GM061738,SCHOOLS OF ARTS AND SCIENCES,PA-12-149,3R01GM061738-13S1,NIGMS:53177\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ALBUQUERQUE,UNITED STATES,BIOLOGY,01,868853094,US,UNIVERSITY OF NEW MEXICO,NM,87131,"PUBLIC HEALTH RELEVANCE: Human muscles contain multiple fiber types, yet there is still much to learn in defining how these fiber types arise and how their fate is controlled. Moreover, a number of human muscle diseases preferentially affect one class of muscles over another. By defining mechanisms for how individual muscle arises in the body, our studies will provide a deeper understanding of how some muscles might be more sensitive to the development of pathologies, and how the symptoms of such diseases might be ameliorated.         ",6380746;,"CRIPPS, RICHARD MATTHEW;","HOODBHOY, TANYA ",05/01/2001,11/30/2014,abstracting;Adult;Affect;Animals;Attention;base;Biochemical;Biological Assay;Cell Culture Techniques;Characteristics;Chest;Chorion;Collaborations;Complement;Complex;Data;Development;Disease;Drosophila genus;Embryo;Employee Strikes;Enhancers;expectation;Fiber;flightin;Funding;Gene Activation;Gene Expression Regulation;Genes;Genetic;Genetic Screening;Goals;Human;In Vitro;in vivo;Individual;insight;Invertebrates;Learning;Mammals;Mediating;Modeling;Molecular;Molecular Genetics;Muscle;Muscle Development;Muscle Fibers;muscle form;mutant;myocyte-specific enhancer-binding factor 2;myogenesis;Myopathy;novel;Pathology;Phenotype;Physiology;Process;programs;Property;Protein Isoforms;public health relevance;Regulation;Regulator Genes;repaired;Research;research study;RNA Interference;Role;Skeletal muscle structure;Specific qualifier value;Structural Genes;Structure;Symptoms;System;Testing;Time;Tissues;transcription factor;Vertebrates;Work,Genetic Regulation of Muscle Fiber Diversity,61738,ZRG1,Special Emphasis Panel,,S1,13,53177,
8743503,R01,GM,3,N,02/05/2014,04/01/2013,03/31/2014,859,R01GM101183,,PA-12-149,3R01GM101183-01A1S1,NIGMS:36910\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,,07,070967955,US,SEATTLE BIOMEDICAL RESEARCH INSTITUTE,WA,98109,"PUBLIC HEALTH RELEVANCE:  The complex web of signals that arise from malaria parasite development within a host hepatocyte is highly medically relevant, as malaria kills more than one million people annually. This proposal seeks to investigate the molecular signals by which the hepatocyte and intracellular pathogen interact over the course of the parasite's liver stage development.            ",7043665;,"KAPPE, STEFAN H.I.;","SLEDJESKI, DARREN D.",04/01/2013,03/31/2017,Antimalarials;Apoptosis;Apoptotic;Attenuated;base;BH3 Domain;Binding (Molecular Function);Cell Cycle Arrest;Cells;Cessation of life;Complex;Data Set;Dependence;Development;Down-Regulation;Ensure;Equilibrium;Erythrocytes;Event;Family member;Fostering;Growth;Health;Hepatocyte;Human;human disease;Immune response;Infection;inhibitor/antagonist;insight;interest;Internet;Intracellular Membranes;Investigation;Killings;knockout gene;Lead;Left;Life Style;Liver;Malaria;Malignant - descriptor;Mediating;Microarray Analysis;Mitochondria;Mitochondrial Proteins;Molecular;Monitor;Mus;Nature;novel;Outer Mitochondrial Membrane;Parasite Control;Parasites;pathogen;Plasmodium;Plasmodium falciparum;Play;Post-Translational Protein Processing;prevent;Prophylactic treatment;Protein p53;Proteins;public health relevance;Regulation;research study;Resistance development;Resources;response;Rodent;Role;Series;Signal Transduction;Signaling Protein;small molecule;Staging;System;Therapeutic;tool;Transgenic Mice;Tumor Suppressor Genes;Vacuole;Variant;Work,Pertubations of Host Cell Signaling by a Complex Hepatotropic Pathogen,101183,,,,A1S1,1,36910,
8795931,R01,GM,3,N,02/06/2014,09/17/2013,05/31/2014,859,R01GM104397,SCHOOLS OF MEDICINE,PA-11-260,3R01GM104397-01A1S1,NIGMS:64592\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,BIOLOGY,01,005421136,US,UNIVERSITY OF CHICAGO,IL,60637,"PUBLIC HEALTH RELEVANCE:     Steroid hormone receptors bind specific DNA sequences and regulate the expression of genes that play key roles in a wide variety of diseases, including cancer, reproductive and immune dysfunction, cardiovascular disease, and disruptions of metabolic and osmotic homeostasis. Understanding how steroid receptors evolved to recognize their DNA targets can help explain how and why these important proteins have the underlying architecture that determines their functions, thus providing fundamental knowledge that will aid in predicting and understanding the effects of steroid receptor genetic variation on changes in transcriptional regulation leading to disease. This project uses computational techniques to infer the history of gene sequences in the receptor family followed by manipulative biochemical techniques to resurrect ancient receptor proteins, experimentally determine their structures and functions, and reconstruct the specific genetic and biochemical mechanisms by which their DNA-binding functions evolved.",8087229;7749678 (contact);,"BRIDGHAM, JAMIE T;THORNTON, JOSEPH W (contact);","ECKSTRAND, IRENE A.",09/17/2013,05/31/2017,Accounting;Androgen Receptor;Androgens;Anisotropy;Architecture;Area;base;Binding (Molecular Function);Binding Sites;Biochemical;Biophysics;Calorimetry;Cardiovascular Diseases;Case Study;Cell physiology;Comparative Study;Computational Technique;Crystallography;Data;deep sequencing;Deuterium;Development;Disease;DNA;DNA Binding;DNA Sequence;driving force;Engineering;Estrogen Receptors;Evolution;experimental analysis;Family;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;Genetic Epistasis;genetic manipulation;Genetic Processes;Glucocorticoids;Goals;Health;high throughput screening;Homeostasis;Hormone Receptor DNA-Binding Domain;Hydrogen;Immune System Diseases;Immunity;Knowledge;Libraries;Link;Malignant Neoplasms;Maps;Metabolic;Methods;Mineralocorticoids;Modeling;molecular dynamics;Mutation;novel;Organism;Phenotype;Phylogenetic Analysis;Physiology;Play;Process;Protein Biochemistry;Protein Family;protein function;Proteins;receptor;receptor binding;reconstruction;Recording of previous events;Regulator Genes;Relative (related person);Reporter;Reproduction;reproductive;research study;Role;Specificity;steroid hormone receptor;Steroid Receptors;Structure;success;synthetic biology;System;Techniques;Thermodynamics;Time;transcription factor;Transcriptional Regulation;Variant;Variation (Genetics);Work,Mechanisms for the evolution of novel DNA specificity in a transcription factor f,104397,GVE,Genetic Variation and Evolution Study Section,,A1S1,1,64592,
8794759,R01,HD,3,N,02/04/2014,02/01/2014,04/30/2014,865,R01HD055300,SCHOOLS OF MEDICINE,PA-11-260,3R01HD055300-06A1S1,NICHD:7607\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,SAN FRANCISCO,UNITED STATES,PSYCHIATRY,12,094878337,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"PUBLIC HEALTH RELEVANCE: Understanding the causes of birth defects is a high priority for public health that is particularly relevant to the mission of the National Institute of Child Healt and Human Development. The research funded by this grant employs genetically-engineered mouse and cell lines to investigate molecular and embryonic origins of complex birth defects in humans. This project will help uncover biological causes of developmental defects leading to many miscarriages, still-births, infant deaths and neonatal surgeries. It will thereby point the wa toward new and improved prenatal diagnostic and therapeutic interventions to minimize miscarriages and birth defects in the United States. Simultaneously, the molecular insights gained through this research may be relevant to some very significant diseases of adults, including in the cardiac and nervous systems.",1911454;,"CHEYETTE, BENJAMIN N.R.;","JAVOIS, LORETTE CLAIRE",05/01/2007,04/30/2018,Address;Adult;Affect;Ally;Animals;Architecture;Behavior;Binding Proteins;Biochemical;Biological;Birth;blastomere structure;Calcium;Calcium Signaling;Cardiac;Cardiovascular system;cell motility;Cell Polarity;Cell Shape;Cells;Child;Collection;Complex;Congenital Abnormality;Custom;Defect;design;Development;Diagnostic;Disease;Dsh protein;Ectoderm;Embryo;embryo tissue;Embryonic Development;Endoderm;Endosomes;Engineering;Epithelial;Failure (biologic function);Family;Family member;FarGo;Funding;Gastrointestinal tract structure;gastrulation;Genetic;Genetically Engineered Mouse;Genitourinary system;Germ Layers;Goals;Grant;Health;Histocompatibility Testing;Human;Human Development;improved;infant death;insight;Institutes;Integral Membrane Protein;Knock-out;Knockout Mice;Laboratories;Link;malformation;Mammals;member;Membrane;Mesenchymal;Mesoderm;Mission;Molecular;Mouse Cell Line;Movement;Mus;mutant;Mutant Strains Mice;Neonatal;Nervous system structure;neurodevelopment;neuropsychiatry;novel;Operative Surgical Procedures;Organ;Outcome;paralogous gene;Pathway interactions;Phenocopy;prenatal;Primitive Streaks;protein degradation;Protein Family;protein function;protein transport;Proteins;Proteomics;public health priorities;receptor;Relative (related person);release of sequestered calcium ion into cytoplasm;Research;rho GTP-Binding Proteins;Role;Scaffolding Protein;Signal Pathway;Signal Transduction;Spectrin;Spontaneous abortion;Testing;Therapeutic Intervention;therapeutic target;Tissues;tool;trafficking;Transgenic Mice;United States;Vascular System;Vertebrates;Vesicle;Work;Writing;Yang,The Dact/Sestd1 pathway in embryonic malformations,55300,GHD,Genetics of Health and Disease Study Section,,A1S1,6,7607,
8791764,R01,HL,3,N,02/06/2014,02/01/2014,06/30/2014,837,R01HL110347,SCHOOLS OF MEDICINE,PA-10-067,3R01HL110347-03S1,NHLBI:20861\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MEMPHIS,UNITED STATES,PHYSIOLOGY,09,941884009,US,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,TN,38163,"Arterial smooth muscle cell ion channels modulate regional blood flow in the brain, but the molecular identity of anion channels, particularly chloride channels, in smooth muscle cells is poorly understood. Pathological alterations in cerebral artery smooth muscle cell ion channels are associated with vascular diseases, including stroke and dementia, but whether chloride channels are involved is unclear. Our proposal will investigate the novel hypothesis that recently discovered TMEM16A chloride channels are expressed in cerebral artery smooth muscle cells where they regulate physiological arterial contraction, and pathological alterations in these channels elevates cerebral artery contractility in hypertension.",6615927;,"JAGGAR, JONATHAN H;","OLIVE, MICHELLE ",07/15/2011,06/30/2016,Angiotensin II;Anions;Antibodies;Arteries;Arteriogram;Attenuated;Blood flow;Brain;Calcium;Caliber;Cations;Cell membrane;cerebral artery;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Chloride Channels;Chloride Ion;Chlorides;Cloning;constriction;Data;Dementia;Disease;Electrophysiology (science);Endothelium;Feedback;Fluorescence Resonance Energy Transfer;Hypertension;Image;Inbred SHR Rats;inhibitor/antagonist;Intracellular Membranes;Investigation;Ion Channel;knock-down;Measures;Mediating;Membrane;Membrane Potentials;mind control;Molecular;Molecular Target;Muscle Cells;Myography;normotensive;novel;patch clamp;Pathway interactions;Physiological;pressure;Property;Protein Splicing;Proteins;Rattus;Reaction;Recombinants;Regional Blood Flow;Regulation;Resistance;response;Risk;RNA Interference;RNA Splicing;Signal Transduction;Smooth muscle (tissue);Smooth Muscle Myocytes;stem;Stimulus;Stretching;stroke;Swelling;Techniques;Testing;Up-Regulation (Physiology);Variant;Vascular constriction (function);Vascular Diseases;Vasodilation;voltage,Arterial Smooth Muscle Chloride Channels,110347,ZRG1,Special Emphasis Panel,,S1,3,20861,
8791438,R01,HL,3,N,02/06/2014,02/01/2014,03/31/2014,837,R01HL113640,SCHOOLS OF MEDICINE,PA-11-260,3R01HL113640-02S1,NHLBI:2591\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MAYWOOD,UNITED STATES,PHYSIOLOGY,07,791277940,US,LOYOLA UNIVERSITY CHICAGO,IL,60153,"Atrial fibrillation (AF) is the most common arrhythmia with an increased risk of mortality and a significant morbidity (e.g. stroke, heart failure) in aging population. This proposal is to investigate the pivotal role of c-jun N-terminal kinase (JNK) in connexin43 suppression that in turn enhances AF in aged atria. The results will provide an important basis for further understanding JNK signaling in the development of AF in aged hearts with co-existing cardiovascular disease (e.g. heart failure), and ultimately developing novel effective therapeutic strategies to prevent AF and/or enhance treatment of AF in the elderly.",10832361;,"AI, XUN;","KRULL, HOLLY ",07/03/2012,03/31/2016,Address;aged;Aging;aging population;Arrhythmia;Atherosclerosis;Atrial Fibrillation;Attention;Attenuated;base;Biochemical;Biological Assay;Cardiac;Cardiovascular Diseases;Cells;Connexin 43;Connexins;Coupling;design;Development;Dominant-Negative Mutation;Down-Regulation;Dyes;Elderly;electric impedance;Electrodes;Elements;Exhibits;expectation;FOS gene;Gap Junctions;Gene Expression;gene repression;Gene Transfer;Genes;Genetic;Goals;Grant;Health;Heart;Heart Atrium;Heart failure;Human;Hypertrophy;improved;In Vitro;in vivo;indexing;innovation;insight;JUN gene;kinase inhibitor;Knock-out;Knockout Mice;Lead;Left atrial structure;Link;link protein;Maintenance;MAP Kinase Gene;MAPK8 gene;MAPK9 gene;Maps;Measurement;Mediating;Messenger RNA;Methods;Molecular;monolayer;Morbidity - disease rate;Mortality Vital Statistics;Mus;Muscle Cells;N-terminal;new therapeutic target;novel;Optics;Oryctolagus cuniculus;Pharmacological Treatment;Phosphorylation;Phosphotransferases;Preparation;Prevalence;prevent;Prevention;Prevention strategy;protein degradation;Protein Isoforms;Proteins;Proto-Oncogene Proteins c-jun;research study;Resistance;response;Risk;Role;Series;Serine;Signal Transduction;Site;SP600125;stress activated protein kinase;stress-activated protein kinase 1;stroke;Techniques;Testing;Therapeutic;Tissues;transcription factor;Transcription Factor AP-1;Transgenic Mice;treatment strategy;Ubiquitin;Ventricular;Wild Type Mouse,JNK Suppression of Connexin43 Enhances Atrial Fibrillation in Aged Atria,113640,ZRG1,Special Emphasis Panel,,S1,2,2591,
8789814,R01,HL,3,N,02/06/2014,02/01/2014,03/31/2014,837,R01HL116917,SCHOOLS OF MEDICINE,PA-11-260,3R01HL116917-01S1,NHLBI:16062\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,PHARMACOLOGY,02,057123192,US,TEMPLE UNIV OF THE COMMONWEALTH,PA,19122,"Elevated level of plasma homocysteine (Hcy), termed hyperhomocysteinemia (HHcy), is an independent risk  factor for human coronary heart disease (CHD) and stroke. Thus, HHcyinduced  chronic vascular inflammation  is a major public health problem. This proposal is to study a new molecular roadmap of how HHcy induces  vascular inflammations. Success of this project will provide new molecular targets for future development of  new therapeutics to treat CHD and stroke.",2106904;,"YANG, XIAO-FENG;","OLIVE, MICHELLE ",02/01/2014,03/31/2017,Accounting;Apolipoprotein E;Apoptosis;Arteries;Atherosclerosis;Autoimmune Process;base;Bax protein;Binding Proteins;Biochemical;Biological;Blood Pressure;Blood Vessels;Bone Marrow;Cardiovascular Diseases;Cells;Cessation of life;Cholesterol;chromatin immunoprecipitation;Chronic;Collaborations;Coronary heart disease;Cystathionine;Data;Development;DNA;DNA Methylation;DNA Methyltransferase;DNA Methyltransferase Inhibitor;DNA Modification Methylases;Event;Functional disorder;Future;Genes;Goals;Homocysteine;Homocystine;Human;Hyperhomocysteinemia;Hyperlipidemia;Immune;Immunosuppressive Agents;Inflammation;Inflammatory;inhibitor/antagonist;interest;Knockout Mice;Laboratories;Lead;Link;Maps;Mediating;Methylation;Molecular;Molecular Target;Morbidity - disease rate;Mortality Vital Statistics;mouse model;Mus;Myocardial Infarction;Natural immunosuppression;Neonatal;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;overexpression;Peripheral;Peripheral arterial disease;peripheral blood;Plasma;prevent;Promotor (Genetics);protein expression;Proteins;public health medicine (field);Publications;Regulatory T-Lymphocyte;Reporting;Risk;Risk Factors;RNA;Role;Small Interfering RNA;Spleen;stroke;Subarachnoid Hemorrhage;success;T-Lymphocyte;Testing;Therapeutic;Tissues;Transgenes;Transgenic Mice;Up-Regulation (Physiology);Vascular Diseases;vascular inflammation;Viral Vector;Water,"HHcy-induced Bax upregulation, Treg apoptosis and vascular disease",116917,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,S1,1,16062,
8792030,R01,HL,3,N,02/06/2014,02/01/2014,12/31/2014,837,R01HL117654,SCHOOLS OF MEDICINE,PA-11-260,3R01HL117654-02S1,NHLBI:79995\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,PHARMACOLOGY,02,057123192,US,TEMPLE UNIV OF THE COMMONWEALTH,PA,19122,PUBLIC HEALTH RELEVANCE: Hyperhomocysteinemia (HHcy) has been identified as a potent risk factor for cardiovascular disease (CVD). However the underlying mechanism remains largely unclear. This hampered the development of effective medical therapies. Recent studies from our group have identified that HHcy inhibit HDL biosynthesis and its function in human and in mice. This proposal seeks to develop a detailed understanding of this regulation with the goal to identify key molecules responsible for HHcy-induced HDL dysfunction and molecular targets for HDL therapy in CVD.,7354290;,"WANG, HONG;","LIU, LIJUAN ",01/16/2013,12/31/2017,acetyl-LDL;Affect;Anabolism;Animals;Apolipoprotein A-I;Apolipoprotein E;apolipoprotein Lp(a+);Apolipoproteins;Arterial Fatty Streak;Atherosclerosis;base;Biochemical;Biochemistry;Biological Assay;Biological Models;Blood Vessels;Cardiovascular Diseases;Catabolism;Cholesterol;cofactor;Coronary heart disease;Cystathionine;Development;DNA Methylation;Dyslipidemias;Endothelial Cells;Enzymes;fast protein liquid chromatography;Fatty Liver;Functional disorder;Gene Expression;gene therapy;Genes;Genetic;Genetic Transcription;Goals;Health;Hepatic;Hepatocyte;High Density Lipoprotein Cholesterol;High Density Lipoprotein therapy;High Density Lipoproteins;Homocysteine;Homocystine;Human;Hyperhomocysteinemia;Hyperlipidemia;in vivo;Knowledge;Label;Link;Lipase;lipid metabolism;Low Density Lipoprotein Receptor;macrophage;Maps;Mediating;Medical;Metabolism;Modeling;Molecular;Molecular Target;Mus;novel;particle;Particle Size;Patients;Plasma;Promotor (Genetics);Proteins;Radiolabeled;radiotracer;Regulation;Reporting;reverse cholesterol transport;Risk Factors;Role;small hairpin RNA;Smoking;Structural Protein;Structure;Testing;Therapeutic;therapeutic target;Transgenic Mice;Translations;Tritium;vector;Vitamins;Water,Hyperhomocysteinemia and HDL Metabolism,117654,ZRG1,Special Emphasis Panel,,S1,2,79995,
8791449,R01,HL,3,N,02/06/2014,02/01/2014,04/30/2014,837,R01HL118376,SCHOOLS OF MEDICINE,PA-11-260,3R01HL118376-01S1,NHLBI:16603\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,09,153890272,US,UNIVERSITY OF MISSOURI-COLUMBIA,MO,65211,"PUBLIC HEALTH RELEVANCE: The fact that one in every three deaths in the United States is caused by cardiovascular disease (CVD) highlights the urgent need for novel therapeutic strategies to combat this disease. Prevalence of over-nutrition and metabolic syndrome (MetS) drive the epidemic of CVD. Insulin resistance that underlies MetS exacerbates vascular complications and increases CVD associated mortality. The standard of care for the treatment of CVD involves extensive use of anti-inflammatory drugs such as rapamycin (Rap) (for example Rap eluting stents) to prevent vascular restenosis and dexamethasone (Dexa) to reduce inflammation. However, accumulating evidence strongly suggest that chronic Rap/Dexa treatments further exacerbate insulin resistance and promote more severe CVD. This proposal seeks funding to investigate a novel therapeutic strategy to attenuate the progression of CVD in conditions of MetS. This approach employs a novel drug, Novokinin (Nov)that suppresses insulin resistance by regulating the diabetic marker miR-29, and promotes vasodilatation and cardiovascular protection by activating the AT2R, a member of the vaso-protective axis of renin-angiotensin system. Results of this integrative and translationally innovative investigation will determine whether Nov attenuates Rap/Dexa-induced insulin resistance in cardiovascular tissues in conditions of MetS and will have a significant impact on the standard of care for CVD in MetS.",8640727;,"PULAKAT, LAKSHMIDEVI;","OLIVE, MICHELLE ",07/03/2013,04/30/2018,Agonist;Angiotensin II Receptor;Anti-inflammatory;Anti-Inflammatory Agents;Attenuated;base;Blood Vessels;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Cessation of life;Chronic;combat;Complement;Complex;Computer Simulation;Data;Dexamethasone;Diabetes Mellitus;diabetic;Disease;Epidemic;Equilibrium;Funding;Growth;Health;Human;human FRAP1 protein;Hyperinsulinism;improved;In Vitro;Individual;Inflammation;innovation;Insulin Resistance;insulin signaling;Investigation;Literature;Mediating;member;Metabolic;Metabolic syndrome;MicroRNAs;Modeling;Mortality Vital Statistics;new therapeutic target;novel;novel therapeutics;Nutrient;nutrition;Obesity;Outcome;Overweight;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phosphotransferases;Prevalence;prevent;Protective Agents;Rattus;Renin-Angiotensin System;response;restenosis;Rodent Model;sensor;Serum;Sirolimus;standard of care;Stents;Testing;Tissues;United States;Up-Regulation (Physiology);Vasodilation,The mTORCI-miR-29-AT2R axis in cardiovascular diseases,118376,ZRG1,Special Emphasis Panel,,S1,1,16603,
8795271,R01,NS,3,N,02/07/2014,01/01/2014,03/31/2014,853,R01NS062092,,PA-07-070,3R01NS062092-04S1,NINDS:15723\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,07,073130411,US,MASSACHUSETTS GENERAL HOSPITAL,MA,02199,"PUBLIC HEALTH RELEVANCE:       Epilepsy remains a devastating and poorly understood illness. The experiments proposed in this project utilize novel techniques to record detailed neuronal activity directly from human cortex before and during seizures. We hope to use these techniques to better appreciate the differences between cortical tissue that will and will not generate seizures and what happens in those different areas as seizures start and spread. The information obtained will allow us to understand the neuronal dynamics underlying epilepsy at an unprecedented level of resolution. This will foster the development of new approaches to seizure prediction, detection and termination as well as more effective surgical management of medically refractory focal epilepsy.",1927400;,"CASH, SYDNEY S;","FUREMAN, BRANDY E",04/01/2010,03/31/2015,Action Potentials;Address;Affect;Agreement;American;Apical;Area;base;Behavior;computerized data processing;Coupling;Data;Dendrites;Detection;Development;directed evolution;Effectiveness;Electroencephalography;Epilepsy;Etiology;Event;Evolution;Fostering;Generations;Health;hippocampal pyramidal neuron;Human;innovation;Investigation;Lead;Light;Location;Measures;Methods;Microelectrodes;Neurons;neurophysiology;novel;novel strategies;Partial Epilepsies;Patients;Pattern;Phase;Physiological;Physiology;Recurrence;Refractory;Relative (related person);research study;Resolution;Role;satisfaction;Seizures;Site;Staging;Stereotyping;Sum;Surgical Management;Synapses;System;Techniques;Testing;Therapeutic;Tissues;tool,Neurophysiology of Human Cortical Epilepsy,62092,ANIE,Acute Neural Injury and Epilepsy Study Section,,S1,4,15723,
8795882,R21,HL,3,N,02/06/2014,02/01/2014,01/31/2015,837,R21HL111907,,PA-11-261,3R21HL111907-02S1,NHLBI:62278\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,,02,073757627,US,CHILDREN'S HOSP OF PHILADELPHIA,PA,191044318,"PUBLIC HEALTH RELEVANCE: Infants born prematurely are often exposed to high concentrations of oxygen (hyperoxia) and this leads to lung injury referred to as bronchopulmonary dysplasia (BPD). This condition leads to long-term sequelae including neurodevelopmental delay. This proposal will address how lung heme oxygenase (HO)-1, the rate limiting enzyme in heme degradation affects the circadian regulating protein Rev-ERB[unreadable] resulting in protection against hyperoxia. These insights may lead to important therapeutic strategies to prevent lung oxidative stress.",1860179;,"DENNERY, PHYLLIS A.;","LAPOSKY, AARON D.",02/01/2014,01/31/2015,Address;Affect;Air;Animals;Biogenesis;Birth;Bronchopulmonary Dysplasia;Cell physiology;Cell Proliferation;Cells;Characteristics;circadian pacemaker;Circadian Rhythms;Cultured Cells;Enzymes;Event;Gene Expression;Genes;Health;Heat shock proteins;Heme;Heme Oxygenase (Decyclizing);Homeostasis;Hyperoxia;in vivo;Infant;Injury;injury and repair;insight;Lead;Life;Ligands;Lung;lung development;lung injury;lung repair;lung volume;Mediating;Metabolism;Mitochondria;Mus;Mutant Strains Mice;Neonatal;Nuclear Receptors;Oxidative Stress;Oxygen;Oxygenases;Phase;Phosphorylation;postnatal;PPAR gamma;prevent;Process;Proteins;Reaction;Recovery;Regulation;repaired;research study;Respiratory physiology;response;rev Protein;Role;Signal Transduction;stress protein;Structure;Structure of parenchyma of lung;Therapeutic;Tissues,Regulation of the Lung Circadian Clock by Heme Oxygenase-1,111907,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,S1,2,62278,
8792485,U01,GH,3,N,02/04/2014,08/15/2013,08/14/2014,,U01GH000048,,RFA-GH-10-003,3U01GH000048-04S1,COGH:387853\,Research Projects,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,NAIROBI,KENYA,,,644035891,KE,KENYA MEDICAL RESEARCH INSTITUTE (KEMRI),,00200,,8790335;,"VULULE, JOHN;","KUMAR, LATA ",08/15/2010,08/14/2015,,GH10-003:  Conducting Public Health Research in Kenya (U01),48,ZGH1,Special Emphasis Panel,,S1,4,387853,
8798710,U01,GH,3,N,02/05/2014,08/15/2013,08/14/2014,,U01GH000048,,RFA-GH-10-003,3U01GH000048-04S2,NCCDPHP:33000\,Research Projects,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,NAIROBI,KENYA,,,644035891,KE,KENYA MEDICAL RESEARCH INSTITUTE (KEMRI),,00200,,8790335;,"VULULE, JOHN;","KUMAR, LATA ",08/15/2010,08/14/2015,,GH10-003:  Conducting Public Health Research in Kenya (U01),48,ZGH1,Special Emphasis Panel,,S2,4,33000,
8790599,U01,HD,3,N,02/05/2014,08/01/2013,07/31/2015,865,U01HD061234,,RFA-HD-09-029,3U01HD061234-05S2,NICHD:347214\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,LIVERPOOL,UNITED KINGDOM,,,291843662,UK,TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE,,L3 5QA,PUBLIC HEALTH RELEVANCE: Preventive iron and folate supplementation in women of reproductive age is widely promoted to reduce anemia prevalence. A weekly supplementation strategy for all women of child-bearing age is an innovative approach recently recommended by WHO.  As malaria prevalence peaks at 13-16 weeks gestation it is essential to assess the safety of this approach in terms of early pregnancy malaria risk in women receiving long-term supplementation.,9602928;,"BRABIN, BERNARD JOHN;","RAITEN, DANIEL J",09/30/2009,07/31/2015,Adherence (attribute);Africa;Africa South of the Sahara;Age;Anemia;Area;base;Burkina Faso;Caring;Cells;Clinical;cohort;Conceptions;Consent;Country;Cross-Sectional Studies;design;Enrollment;Falciparum Malaria;Female of child bearing age;First Pregnancy Trimester;Folate;Folic Acid;follow-up;Goals;Good Clinical Practice;Healthcare;High Prevalence;high risk;Incidence;Infection;innovation;Intention;Intervention;Iron;iron deficiency;Iron deficiency anemia;iron supplement;iron supplementation;Life;Malaria;Measures;Monitor;Morbidity - disease rate;Outcome Measure;Parasitemia;Placebos;Plasmodium falciparum;Population;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Prevalence;prevent;Preventive;primary outcome;Principal Investigator;public health relevance;Randomized Controlled Trials;randomized placebo controlled trial;reproductive;Resources;Risk;Rural;Safety;Sampling;Seasons;secondary outcome;Supplementation;Testing;Visit;Woman;young woman,Long-term WIFS and malaria risk in early pregnancy: a randomized controlled trial,61234,ZHD1,Special Emphasis Panel,,S2,5,347214,
8793915,U01,HL,3,N,02/06/2014,02/01/2014,07/31/2014,837,U01HL114377,SCHOOLS OF ARTS AND SCIENCES,RFA-DK-10-014,3U01HL114377-03S2,NHLBI:12163\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN LUIS OBISPO,UNITED STATES,MISCELLANEOUS,22,029326246,US,CALIFORNIA POLY STATE U SAN LUIS OBISPO,CA,93407,"RELEVANCE (See instructions):  This research project will help identify an effective program to help obese women gain a healthy amount of  weight (and not too much) during pregnancy. If effective, this lifestyle program has the potential to prevent  health problems in obese women and their offspring.",8275005;,"PHELAN, SUZANNE;","ARTEAGA, SONIA M",09/23/2011,07/31/2016,Adherence (attribute);Affect;Age-Months;Apgar Score;base;Behavior;Behavior Therapy;Behavioral;Birth trauma;Blood Pressure;Body Image;Calories;Constipation;Cromolyn Sodium;Diet;Diet good;Disinhibition;Eating;Environment;Equilibrium;Ethnicity aspects;Exercise;fast food;Fasting;Fatty acid glycerol esters;Feedback;Food;Frequencies (time pattern);Gestational Diabetes;Glucose;Goals;Health;Hispanics;Home environment;improved;Incidence;Infant;innovation;Institute of Medicine (U.S.);Instruction;Insulin;Intake;Intervention;Length;Life Style;lifestyle intervention;Lipids;Liquid substance;Low Birth Weight Infant;Measures;meetings;Modeling;Moods;Mothers;Not Hispanic or Latino;nutrition;Nutritional;Obesity;offspring;Overweight;Participant;Physical activity;Physiological;Population;Postpartum Period;Pre-Eclampsia;Pregnancy;prevent;Prevention;Procedures;programs;psychosocial;Publishing;Randomized;Randomized Controlled Trials;randomized trial;Recommendation;Recruitment Activity;Relative (related person);Research;Research Project Grants;restraint;sedentary;Site;sound;standard care;sugar;sweetened beverage;Testing;Time;Very Light Exercise;Weight;Weight Gain;Weight maintenance regimen;Woman;Work,Preventing excessive gestational weight gain in obese women,114377,ZDK1,Special Emphasis Panel,,S2,3,12163,
8794050,U10,DA,3,N,02/04/2014,09/01/2013,08/31/2014,279,U10DA013035,,RFA-DA-10-009,3U10DA013035-12S1,NIDA:1839069\,Other Research Related,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,10032,"PUBLIC HEALTH RELEVANCE:'Addictions, including nicotine, drugs, and alcohol, represent a major public health problem. Research is needed to translate new basic and therapeutic advances into effective and accessible treatment in our communities, The NIDA Clinical Trials Network, and the Greater New York Node proposed here, seek to fill this gap by engaging researchers and community-based providers collaboratively in treatment research.",8192463 (contact);2414926;,"NUNES, EDWARD V (contact);ROTROSEN, JOHN P;","DOBBINS, RONALD ",09/01/1999,08/31/2015,addiction;Address;Adoption;Alcohols;Area;base;Behavior Therapy;Clinical;Clinical Trials;Clinical Trials Network;Communities;community based treatment;Disease;effectiveness research;Epidemiology;Evidence based practice;experience;Fostering;Freedom;Future;Gender Issues;Genetic;Health;Health Services Research;Healthcare;Healthcare Systems;HIV risk;Hospitals;Housing;Human Resources;innovation;Lead;Leadership;Long Island;Mainstreaming (Education);Medical;meetings;member;metropolitan;Mission;Modeling;National Institute of Drug Abuse;Neurosciences;New York;New York City;Nicotine;performance site;Pharmaceutical Preparations;Pharmacotherapy;Phase;Policies;Population;Private Hospitals;Productivity;programs;protocol development;Protocols documentation;Provider;public health medicine (field);Public Hospitals;quality assurance;Regulatory Affairs;Research;Research Activity;Research Personnel;Research Support;research to practice;Resources;Risk Reduction;Scientist;Services;Site;Staging;Structure;Substance abuse problem;Supervision;System;Technology;Therapeutic;Training;Translating;treatment program;Universities;Vision,Clinical Trials Network: Greater New York Node,13035,ZDA1,Special Emphasis Panel,,S1,12,1839069,
8796786,U10,DA,3,N,02/04/2014,09/01/2013,08/31/2014,279,U10DA020024,SCHOOLS OF MEDICINE,RFA-DA-10-009,3U10DA020024-09S1,NIDA:1047032\,Other Research Related,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,DALLAS,UNITED STATES,PSYCHIATRY,30,800771545,US,UT SOUTHWESTERN MEDICAL CENTER,TX,753909105,,1866690;,"TRIVEDI, MADHUKAR H.;","DOBBINS, RONALD ",09/01/2005,08/31/2015,addiction;Address;Admission activity;Adolescent;Adopted;Adoption;Adult;African American;Alcohol or Other Drugs use;Algorithms;Area;austin;career development;chronic pain;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Network;Commit;Communities;Complement;data management;design;Development;Disease;Effectiveness;effectiveness clinical trial;effectiveness trial;experience;Faculty;Female;Female Adolescents;Funding;Funding Mechanisms;Future;Grant;Health Personnel;Hispanics;HIV;innovation;Inpatients;Intervention;Joints;K-Series Research Career Programs;Latino;Lead;Medical;Medical center;medical specialties;Mental disorders;metropolitan;Minority;Monitor;Multi-Institutional Clinical Trial;National Institute of Drug Abuse;next generation;novel strategies;organizational structure;Outpatients;outreach program;Patients;Performance;Pharmaceutical Preparations;Pharmacological Treatment;Policies;Population;Population Study;pre-clinical;preclinical study;Procedures;Production;Protocols documentation;Publications;Research;Research Personnel;Resources;Site;Structure;Substance Use Disorder;System;Texas;Training;treatment program;Universities;Voice;Work,Clinical Trials Network: The Texas Node,20024,ZDA1,Special Emphasis Panel,,S1,9,1047032,
8798916,U19,DE,3,N,02/06/2014,02/01/2014,01/31/2015,121,U19DE018385,SCHOOLS OF DENTISTRY/ORAL HYGN,PAR-05-031,3U19DE018385-05S1,NIDCR:181467\,Research Projects,2014,NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH,,NEW YORK,UNITED STATES,OTHER BASIC SCIENCES,12,041968306,US,NEW YORK UNIVERSITY,NY,100122331,,1891400;,"MALAMUD, DANIEL;","RODRIGUEZ-CHAVEZ, ISAAC R.",08/01/2007,01/31/2015,Acquired Immunodeficiency Syndrome;Advisory Committees;AIDS/HIV problem;Anti-Bacterial Agents;antiretroviral therapy;Antiviral Agents;Bacteria;Biological Response Modifiers;Biopsy Specimen;Blood;Case-Control Studies;Clinical;cohort;college;Data;Dental caries;Dentistry;Diamond;Endoscopy;gastrointestinal;Goals;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV-1;Host Defense;In Vitro;Interdisciplinary Study;Liquid substance;medical schools;Microbe;microbial;National Institute of Dental and Craniofacial Research;New York City;Oral;Oral health;Oral Manifestations;Patient Monitoring;Periodontal Diseases;Population;Principal Investigator;Records;rectal;Research;Research Personnel;Research Project Grants;Saliva;saliva proteome;Sampling;Statistical Data Interpretation;System;Tissues;Variant,"Crosstalk Among Oral &Gastrointestinal Soluble Innate Factors, HIV, &Microbes",18385,ZDE1,Special Emphasis Panel,,S1,5,181467,
8797882,U2G,GH,3,N,02/04/2014,09/30/2013,09/29/2014,,U2GGH000086,,RFA-GH1-1-1134,3U2GGH000086-03S1,COGH:500000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,BLANTYRE,MALAWI,,,954523093,MI,MALAWI BLOOD TRANSFUSION SERVICE,,,,8734994;,"MBAYA, BRIDON;",,09/30/2011,09/29/2016,,"PROVIDING A SAFE, ADEQUATE AND RELIABLE SUPPLY OF BLOOD AND BLOOD PRODUCTS TO HOS",86,ZGH1,Special Emphasis Panel,,S1,3,500000,
8803415,U2G,GH,3,N,02/07/2014,09/30/2013,09/29/2014,067,U2GGH000199,,RFA-GH1-1-1144,3U2GGH000199-03S1,COGH:599969\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,HARARE,ZIMBABWE,,,653161591,ZI,BIOMEDICAL RESEARCH &TRAINING INSTITUTE,,na,,10913286;,"GOMO, EXNEVIA;",,09/30/2011,09/29/2016,,ZIMBABWE INFECTION PREVENTION AND CONTROL PROJECT,199,ZGH1,Special Emphasis Panel,,S1,3,599969,
8796775,U2G,GH,3,N,02/04/2014,09/30/2013,09/29/2014,,U2GGH000263,,RFA-GH1-1-1194,3U2GGH000263-03S1,COGH:1600000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,PORT-AU-PRINCE,HAITI,,,872038062,HA,INTERNATIONAL CHILD CARE,,ht6141,,11078673;,"GEFFRARD, HARRY;",,09/30/2011,09/29/2016,,INTEGRATING HIV CARE AND TREATMENT WITHIN THE NETWORK OF FACILITIES OFFERING TB T,263,ZGH1,Special Emphasis Panel,,S1,3,1600000,
8796785,U2G,GH,3,N,02/04/2014,09/30/2013,09/29/2014,,U2GGH000278,,RFA-GH1-1-1193,3U2GGH000278-03S1,COGH:6100000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,BOSTON,UNITED STATES,,07,602352924,US,PARTNERS IN HEALTH,MA,02215,,2117910;,"MUKHERJEE, JOIA S;",,09/30/2011,09/29/2016,,"GH11-1193: STRENGTHENING INTEGRATED HIV AND CHOLERA CARE, ",278,ZGH1,Special Emphasis Panel,,S1,3,6100000,
8803041,U2G,GH,3,N,02/07/2014,09/30/2013,09/29/2014,067,U2GGH000315,,RFA-GH1-1-1148,3U2GGH000315-03S1,COGH:1950000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,HARARE,ZIMBABWE,,,,ZI,UNIVERSITY OF ZIMBABWE,,,,10903544;,"TSHIMANGA, MUFUTA;",,09/30/2011,09/29/2016,,EPIDEMIOLOGY AND STRATEGIC INFORMATION IN THE REPUBLIC OF ZIMBABWE UNDER THE PRES,315,ZGH1,Special Emphasis Panel,,S1,3,1950000,
8802905,U2G,GH,3,N,02/06/2014,09/30/2013,09/29/2014,067,U2GGH000323,,RFA-GH1-1-1147,3U2GGH000323-03S1,COGH:450000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,HARARE,ZIMBABWE,,,,ZI,UNIVERSITY OF ZIMBABWE,,,,11059236;,"SIMBINI, TUNGAMIRIRAI;",,09/30/2011,09/29/2014,,STRENGTHENING HUMAN RESOURCE INFORMATION SYSTEMS IN THE REPUBLIC OF ZIMBABWE,323,ZGH1,Special Emphasis Panel,,S1,3,450000,
8796668,U2G,GH,3,N,02/04/2014,09/30/2013,09/29/2014,,U2GGH000548,SCHOOLS OF MEDICINE,RFA-GH1-1-1191,3U2GGH000548-03S1,COGH:1300000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,CORAL GABLES,UNITED STATES,FAMILY MEDICINE,27,052780918,US,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,FL,331462926,,10919719;,"DODARD, MICHEL JOSEPH;",,09/30/2011,09/29/2016,,IMPROVEMENT OF INTEGRATED HIV CLINICAL-BASED SERVICES,548,ZGH1,Special Emphasis Panel,,S1,3,1300000,
8796820,U2G,GH,3,N,02/04/2014,09/30/2013,09/29/2014,,U2GGH000549,SCHOOLS OF MEDICINE,RFA-GH1-1-1191,3U2GGH000549-03S1,COGH:1000000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472,,8254617;,"BARNHART, SCOTT;",,09/30/2011,09/29/2016,,GH11-1191 IMPROVEMENT OF INTERGRATED HIV CLINICAL-BASED SERVICES ,549,ZGH1,Special Emphasis Panel,,S1,3,1000000,
8796744,U2G,GH,3,N,02/04/2014,07/01/2013,06/30/2014,,U2GGH000624,,RFA-GH1-2-1209,3U2GGH000624-02S1,COGH:1087250\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,KAMPALA,UGANDA,,,,UG,CHILDREN'S AIDS FUND UGANDA,,,,11470155;,"BITARABEHO, JACKSON;",,07/01/2012,06/30/2017,,"NEW HOPE PROJECT-PROVISION OF COMPREHENSIVE HIV/AIDS CARE, TREATMENT, PREVENTION",624,ZGH1,Special Emphasis Panel,,S1,2,1087250,
8798363,U2G,GH,3,N,02/04/2014,09/30/2013,09/29/2014,,U2GGH000649,,RFA-GH1-2-1249,3U2GGH000649-02S1,COGH:1487325\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,LILONGWE,MALAWI,,,850452728,MI,LIGHTHOUSE TRUST,,,,8991144;,"PHIRI, SAM;",,09/30/2012,09/29/2017,,CENTER OF EXCELLENCE FOR COMPREHENSIVE INTEGRATED HIV Care ,649,ZGH1,Special Emphasis Panel,,S1,2,1487325,
8802102,U2G,GH,3,N,02/05/2014,02/01/2013,03/31/2014,,U2GGH000837,,RFA-GH1-2-1239,3U2GGH000837-01S1,COGH:300000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,DAR ES SALAAM,TANZANIA U REP,,,565438611,TZ,MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS,,65001,,9220054;,"KILONZO, GAD PAUL;",,02/01/2013,01/31/2018,,TAPP2: EXPANDING COMPREHENSIVE HIV PREVENTION SERVICES FOR INJECTION DRUG USERS A,837,ZGH1,Special Emphasis Panel,,S1,1,300000,
8802675,U2G,GH,3,N,02/06/2014,09/30/2013,09/29/2014,067,U2GGH001023,,RFA-GH1-3-1330,3U2GGH001023-01S1,COGH:1675000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,HARARE,ZIMBABWE,,,,ZI,ZIMBABWE ASSOCIATION OF CHURCH HOSPITALS,,,,11784993;,"SIDILE-CHITIMBIRE, VUYELWA;",,09/30/2013,09/29/2018,,EXPANSION OF HIV/AIDS CARE AND PREVENTION,1023,ZGH1,Special Emphasis Panel,,S1,1,1675000,
8799602,U2G,PS,3,N,02/05/2014,09/30/2013,09/29/2014,,U2GPS002091,,RFA-PS0-9-9118,3U2GPS002091-05S1,COGH:3150000\,Unknown,2014,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,KIGALI,RWANDA,,,850452805,RW,RWANDA MINISTRY OF HEALTH,,,,10529691;,"KANKINDI, MD, IDA;",,09/30/2009,09/29/2014,,STRENGTHENING THE CAPACITY OF THE MINISTRY OF HEALTH TO RESPOND TO THE HIV/AIDS E,2091,ZPS1,Special Emphasis Panel,,S1,5,3150000,
8802962,U2G,PS,3,N,02/06/2014,09/30/2013,09/29/2014,,U2GPS002713,,RFA-PS1-0-1035,3U2GPS002713-04S2,COGH:2849999\,Unknown,2014,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,ABIDJAN,COTE D'IVOIRE,,,,IV,NATIONAL BLOOD TRANSFUSION CENTER,,,,11301675;,"SEIDOU, KONATE;",,09/30/2010,09/29/2015,,SUPPORTING THE NBTS IN THE IMPLEMENTATION AND EXPANSION OF BLOOD SAFWTY ACTIVITIE,2713,ZPS1,Special Emphasis Panel,,S2,4,2849999,
8793999,U2G,PS,3,N,01/31/2014,08/28/2013,08/31/2014,,U2GPS002716,,RFA-PS1-0-1054,3U2GPS002716-04S4,COGH:25000\,Unknown,2014,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,KIGALI,RWANDA,,,557737841,RW,KIGALI HEALTH INSTITUTE,,,,12109093;,"ROMAN, NTARE;",,09/01/2010,08/31/2015,,SUPPORTING THE KIGALI HEALTH INSTITUTE TO STRENGTHEN LABORATORY TRAINING IN RWAND,2716,ZPS1,Special Emphasis Panel,,S4,4,25000,
8796794,U2G,PS,3,N,02/03/2014,09/30/2013,09/29/2014,,U2GPS002728,,,3U2GPS002728-04S2,COGH:1803877\,Unknown,2014,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,KAMPALA,UGANDA,,,565537557,UG,"AFRICAN FIELD EPIDEMIOLOGY NETWORK, LTD",,,,10642976;,"MOSHA, FAUSTA;",,09/30/2010,09/29/2015,,"PROFICIENCY TESTING FOR HIV RAPID TESTS, BIOLOGICAL SAFETY CABINET CERTIFICATION ",2728,ZPS1,Special Emphasis Panel,,S2,4,1803877,
8803420,U2G,PS,3,N,02/07/2014,09/30/2013,09/29/2014,067,U2GPS002895,,,3U2GPS002895-04S1,COGH:275000\,Unknown,2014,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,HARARE,ZIMBABWE,,,,ZI,UNIVERSITY OF ZIMBABWE,,,,10903544;,"TSHIMANGA, MUFUTA;",,09/30/2010,09/29/2015,,STRENGTHENING THE MASTER'S LEVEL PUBLIC HEALTH TRAINING PROGRAM IN THE REPUBLIC O,2895,ZPS1,Special Emphasis Panel,,S1,4,275000,
8803140,U2G,PS,3,N,02/07/2014,09/30/2013,09/29/2014,067,U2GPS003002,,,3U2GPS003002-04S1,COGH:650000\,Unknown,2014,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,HARARE,ZIMBABWE,,,,ZI,UNIVERSITY OF ZIMBABWE,,,,10508411;,"RUSAKANIKO, SIMBARASHE;",,09/30/2010,09/29/2015,,DEVELOPMENT OF HEALTH LEADERSHIP CAPACITY AND SUPPORT OF HUMAN RESOURCES FOR HEAL,3002,ZPS1,Special Emphasis Panel,,S1,4,650000,
8803072,U2G,PS,3,N,02/07/2014,09/30/2013,09/29/2014,067,U2GPS003064,,,3U2GPS003064-04S1,COGH:304000\,Unknown,2014,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,HARARE,ZIMBABWE,,,,ZI,NATIONAL BLOOD SERVICE ZIMBABWE,,,,10520910;,"MVERE, DAVID;",,09/30/2010,09/29/2015,,PREVENTION OF HIV TRANSMISSION THROUGH STRENGTHENING BLOOD SAFETY IN THE REPUBLIC,3064,ZPS1,Special Emphasis Panel,,S1,4,304000,
8794906,U2G,PS,3,N,02/07/2014,09/30/2013,09/29/2014,067,U2GPS003118,,,3U2GPS003118-04S1,COGH:1430000\,Unknown,2014,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,RESEARCH TRIANGLE,UNITED STATES,,04,004868105,US,RESEARCH TRIANGLE INSTITUTE,NC,277092194,,11873667;,"SEMBAJWE, EILEEN;",,09/30/2010,09/29/2015,,BUILDING HEALTH DATA DISSEMINATION AND INFORMATION USE SYSTEMS IN THE REPUBLIC OF,3118,ZPS1,Special Emphasis Panel,,S1,4,1430000,
8796784,U51,GH,3,N,02/03/2014,08/15/2013,08/14/2014,067,U51GH000970,,RFA-GH1-3-1306,3U51GH000970-01S1,COGH:590000\,Unknown,2014,COORDINATING OFFICE OF GLOBAL HEALTH,,GUATEMALA,GUATEMALA,,,846107027,GT,UNIVERSITY OF THE VALLEY OF GUATEMALA,,01015,,6864071;,"CORDON-ROSALES, CELIA;",,08/15/2013,08/14/2018,,EVIDENCE &INNOVATIONS FOR PUBLIC HEALTH ACTIONS IN GUATEMALA &CENTRAL AMERICA,970,ZGH1,Special Emphasis Panel,,S1,1,590000,
8741167,U54,GM,3,N,02/04/2014,07/01/2013,06/30/2014,859,U54GM094599,SCHOOLS OF ARTS AND SCIENCES,PA-12-149,3U54GM094599-04S1,NIGMS:31421\,Research Centers,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,TEMPE,UNITED STATES,CHEMISTRY,05,943360412,US,ARIZONA STATE UNIVERSITY-TEMPE CAMPUS,AZ,852876011,"The major goal of the Center for Membrane Proteins in Infectious Diseases is to determine structures of membrane proteins involved in pathogenesis. The focus is on medically important viral and bacterial membrane proteins and human membrane proteins involved in their pathogenic pathways. The Center uses the biological theme of infectious diseases as the basis for the determination of novel membrane protein structures and to develop new technologies for high throughput membrane protein expression, isolation, functional characterization, crystallization and structure determination.",7844167;,"FROMME, PETRA;","EDMONDS, CHARLES G.",09/30/2010,06/30/2015,Affinity;base;Base Sequence;Biochemical;Bioinformatics;Biological;Biology;Cells;chemical property;Communicable Diseases;Communities;Complement;Complementary DNA;Complex;Computer Simulation;computerized tools;Coupled;Crystallization;Databases;design;Detergents;Development;Dialysis procedure;Drug Targeting;Escherichia coli;Evaluation;Fermentation;Fluorescence;Gene Expression;gene synthesis;Generations;Genes;Goals;Health;Host Defense;Human;In Vitro;in vivo;Informatics;innovation;Insecta;Knowledge;Lipids;magnetic beads;Membrane;Membrane Proteins;Methodology;Methods;Micelles;Modeling;Molecular;Mono-S;multidisciplinary;new technology;novel;Nucleic Acids;pathogen;Pathogenesis;Pathway interactions;Peptides;Phase;Plants;Play;Precipitation;Prevention;Procedures;Process;Protein Array;protein expression;protein purification;protein structure;Protein Structure Initiative;protein structure prediction;Proteins;Protocols documentation;Quality Control;Roentgen Rays;Role;scale up;Scheme;screening;Structure;System;Techniques;Technology;technology development;tool;Vaccinia;Vaccinium;Validation;Variant;vector;Viral;Viral Matrix Proteins;X-Ray Crystallography;Yeasts,Center for Membrane Proteins in Infectious Diseases (MPID),94599,,,,S1,4,31421,
8795992,UM1,AI,3,N,02/05/2014,02/01/2014,05/31/2014,855,UM1AI068641,SCHOOLS OF PUBLIC HEALTH,RFA-AI-05-001,3UM1AI068641-08S1,NIAID:3416188\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MINNEAPOLIS,UNITED STATES,BIOSTATISTICS &OTHER MATH SCI,05,555917996,US,UNIVERSITY OF MINNESOTA,MN,554552070,,1875442;,"NEATON, JAMES DENNIS;","DECARLO, ELLEN S.",06/29/2006,05/31/2015,abstracting;Address;adjudicate;Adverse effects;antiretroviral therapy;Biometry;Clinical Management;clinically relevant;cohort;Comorbidity;cost;cost efficient;Country;data management;Data Quality;Data Set;Databases;design;Disease-Free Survival;Enrollment;Epidemiology;follow-up;Fostering;HIV;Individual;International;International Network for Strategic Initiatives in Global HIV Trials;Intervention;Laboratories;Location;Minnesota;Mission;Morbidity - disease rate;Mortality Vital Statistics;Nested Case-Control Study;Operations Research;organizational structure;Outcome;Population Heterogeneity;prevent;Productivity;Public Health Schools;quality assurance;Randomized;randomized trial;repository;Research;Resource Sharing;Resources;Services;Site;Specimen;Therapeutic Intervention;Time;Universities,International Network for Strategic Initiatives in Global HIV Trials (INSIGHT),68641,ZAI1,Special Emphasis Panel,,S1,8,3416188,
8591174,F32,AG,4,N,02/07/2014,12/01/2013,11/30/2014,866,F32AG040957,,PA-11-113,4F32AG040957-02,NIA:46092\,"Training, Individual",2014,NATIONAL INSTITUTE ON AGING,,"Rehovot, Israel",ISRAEL,,,600048466,IS,WEIZMANN INSTITUTE OF SCIENCE,,76100,"PUBLIC HEALTH RELEVANCE:  Alzheimer's disease (AD), the most common neurodegenerative disorder, is an age- dependent disorder resulting in progressive loss of cognitive function. It carries an estimated annual burden of over 100 billion dollars in the United States when caregiver's medical expenses and lost productivity are included.            ",10744909;,"SMITH, PIETER ERNST;","REFOLO, LORENZO ",12/01/2012,11/30/2014,Affect;age related;aggregation pathway;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid fibers;aqueous;Autopsy;Behavior;Biological;Biological Models;Brain;Caregivers;Cell Culture Techniques;Cell Nucleus;Chemicals;Clinical;cognitive function;conformer;cytotoxicity;Data Set;Deposition;Detection;Development;Diffusion;Dimensions;Disease;Elderly;Employee Strikes;Environment;Equilibrium;Etiology;Evolution;extracellular;Frequencies (time pattern);Goals;Homo;Human;In Vitro;in vivo;innovation;insight;interest;Investigation;Laboratories;Life;Measurement;Measures;Medical;Methodology;Methods;Minority;Modification;Molecular;molecular size;monomer;mouse model;Nature;Neurodegenerative Disorders;NMR Spectroscopy;Nuclear;Onset of illness;Oocytes;Pathology;Patients;Peptides;Phenotype;Play;polymerization;Process;Productivity;Property;public health medicine (field);public health relevance;Quality of life;Radial;Relaxation;research study;Role;Sampling;Scheme;Severities;Signal Transduction;Site;Solutions;spectroscopic imaging;Speed (motion);Staging;Structure;Symptoms;System;Techniques;Time;TOCSY;tool;Transgenic Organisms;United States;Variant;Xenopus laevis;Xenopus oocyte,Elucidating the mechanism of amyloid-beta's pathological aggregation,40957,ZRG1,Special Emphasis Panel,,,2,46092,
8786916,R00,EY,4,N,02/04/2014,01/01/2014,12/31/2014,867,R00EY020518,BIOMED ENGR/COL ENGR/ENGR STA,PA-09-036,4R00EY020518-03,NEI:248999\,Research Projects,2014,NATIONAL EYE INSTITUTE,,MEMPHIS,UNITED STATES,ENGINEERING (ALL TYPES),09,055688857,US,UNIVERSITY OF MEMPHIS,TN,38152,"PROJECT NARRATIVE  Detecting the onset and progression of glaucomatous changes in the eye is central to glaucoma diagnosis and management. This multidisciplinary project focuses on developing powerful (high-performance) computational, mathematical, and statistical techniques for detecting volumetric glaucomatous changes from the Confocal Scanning Laser Ophthalmoscopy (CSLO) scans and volumetric Spectral Domain Optical Coherence Tomography (SD-OCT) scans of the optic nerve head. In addition, the Principal Investigator of this proposal will receive extensive training in the areas of computational mathematics and computer vision to augment and strengthen his multidisciplinary expertise essential to execute the proposed specific aims.",9860691;,"BALASUBRAMANIAN, MADHUSUDHANAN;","CHIN, HEMIN R",01/01/2014,12/31/2016,3-Dimensional;Address;Advisory Committees;Affect;analytical tool;Architecture;Area;base;bioimaging;Biology;Blindness;blood flow measurement;Brain imaging;Bruch's basal membrane structure;cancer imaging;Cardiology;Clinic;Clinical;Complex;Computational Technique;computer framework;computer science;Computer Vision Systems;Confocal Microscopy;cost;Data;Data Set;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;Disease Progression;Doctor of Philosophy;Educational workshop;Elements;Engineering;Eye;Functional disorder;Gastroenterology;Generations;Genetic screening method;Glaucoma;Goals;Gold;Grant;Health;Image;improved;instrument;Interferometry;Lasers;Lead;Left;Mathematics;Measurement;Measures;medical specialties;Medicine;Membrane;Mentors;Methodology;Modeling;Monitor;multidisciplinary;National Eye Institute;National Institute of Biomedical Imaging and Bioengineering;Onset of illness;Ophthalmology;Ophthalmoscopes;Ophthalmoscopy;Optic Disk;optic imaging;optic nerve disorder;Optical Coherence Tomography;Optics;Outcome;Patients;Performance;Phase;prevent;Principal Investigator;programs;Recommendation;Research;Research Personnel;Research Training;Resolution;Retinal;retinal nerve fiber layer;Scanning;Science;Sensitivity and Specificity;Structure;Surface;symposium;Techniques;Technology;Time;time use;Training;Treatment Effectiveness;Treatment Protocols;Validation;Vision;Vision research;Visit,New Techniques for Measuring Volumetric Structural Changes in Glaucoma,20518,NSS,No Study Section (in-house review),,,3,248999,
8610246,R21,HL,4,N,02/06/2014,02/01/2014,01/31/2015,837,R21HL114238,,PAR-11-032,4R21HL114238-03,NHLBI:114467\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WYNDMOOR,UNITED STATES,,13,144273096,US,U.S. AGRICULTURAL RESEARCH SERVICE,PA,190388598," This study proposes to identify genetic variants, mainly single nucleotide polymorphisms that are likely to participate in gene-environment interactions for phenotypes relevant to metabolic syndrome: blood lipids, blood pressure, obesity (body mass index) and plasma glucose and insulin levels. This study, of original and novel design, will use expression QTL SNPs and gene expression changes induced by EF exposure coupled with gene networks built with genes participating in specific types of published GxE interactions in order to identify new putative GxE SNPs. Those SNPs will be tested with genotyping data available from two deeply phenotyped populations. This project will provide techniques enabling our understanding of how widespread afflictions such as cardiovascular disease, type 2 diabetes and hypertension/stroke are and to what extent the genetic risk of these sicknesses is modulated by environmental factors. In essence, this study will help to define how the genome senses and responds to diet, exercise and alcohol/tobacco use.            ",10802535;,"PARNELL, LAURENCE;","JAQUISH, CASHELL E.",02/16/2012,01/31/2015,Adoption;Affect;Alcohol consumption;alcohol exposure;Alcohols;Alleles;Altitude;anticancer research;base;Behavior;Bioinformatics;blood lipid;Blood Pressure;Body mass index;Caloric Restriction;Carbohydrates;Cardiovascular Diseases;Clinical;Code;combat;Complex;Computational Biology;Coupled;Cues;Data;Data Set;design;Diabetes Mellitus;Diet;diet and exercise;Dietary Component;Dietary Fats;dietary restriction;Disease;disease phenotype;disorder risk;Dyslipidemias;Elements;Environment;Environmental Exposure;Environmental Risk Factor;Exclusion;Exercise;Exhibits;Exons;Experimental Designs;Fatty acid glycerol esters;gene environment interaction;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Gene Proteins;Genes;Genetic;genetic association;genetic element;Genetic Risk;Genetic Transcription;genetic variant;Genome;genome wide association study;genome-wide;Genomics;Genotype;Glucose;Goals;Health Status;Heart;Heart Diseases;Heritability;Human;human disease;human population genetics;Hypertension;Individual;innovation;Insulin;Life Style;Linkage Disequilibrium;Lipids;Maps;Measures;Messenger RNA;Metabolic syndrome;Methodology;Methods;Mining;Nature;Network-based;Non-Insulin-Dependent Diabetes Mellitus;novel;nutritional genomics;Obesity;Participant;Pharmaceutical Preparations;Phenotype;Physical activity;Plasma;Population;Population Genetics;Population Statistics;Process;protein protein interaction;protein structure function;Proteins;Publishing;Qualifying;Quantitative Trait Loci;rapid detection;Research;Research Institute;research study;residence;response;Rodent;Role;Scientist;Series;Signal Transduction;Single Nucleotide Polymorphism;Sleep;Smoking;Stimulus;stroke;System;Systems Biology;Techniques;Testing;To specify;Tobacco use;trait;Variant;Variation (Genetics);Work,Gene expression and system-based analysis to predict gene-environment interaction,114238,BCHI,Biomedical Computing and Health Informatics Study Section,,,3,114467,
8791393,R33,DA,4,N,02/01/2014,02/01/2014,01/31/2015,279,R33DA032837,,PAS-10-274,4R33DA032837-03,NIDA:499911\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,RESEARCH TRIANGLE,UNITED STATES,,04,004868105,US,RESEARCH TRIANGLE INSTITUTE,NC,277092194,"Emerging evidence suggests that orexin 1 receptor play a critical role in a variety of physiological processes including reward and motivation and therefore, represent a valuable target in medication development for the treatment of drug abuse and addiction. This project plans to develop potent and selective agonists and antagonists for this receptor. These ligands will serve as tools to probe the signaling mechanisms and in vivo function of this receptor, and could expedite the ultimate development of novel therapies for the treatment of conditions mediated by orexin signaling including drug abuse and addiction.",8787612;,"ZHANG, YANAN;","SINGH, HARI ",02/01/2014,01/31/2016,Adverse effects;Agonist;Amino Acid Substitution;Amino Acids;analog;Animals;base;Behavioral;biological adaptation to stress;Biological Assay;Biological Availability;Blood - brain barrier anatomy;Brain;Calcium;chemical synthesis;Computer Simulation;Cues;Development;Dose;drug abstinence;Drug abuse;Drug Addiction;Drug Kinetics;Goals;hypocretin;improved;in vivo;Lead;Libraries;Ligands;Mediating;Modeling;Molecular Conformation;Motivation;novel;orexin 1 receptor;orexin A;Pathway interactions;Pattern;Penetration;Peptide Fragments;Peptide Library;Peptides;peptidomimetics;Peptoids;Pharmaceutical Preparations;Pharmacology;pharmacophore;Phase;Physiological;Physiological Processes;Play;Posture;Principal Investigator;programs;Property;Proteolysis;receptor;receptor binding;receptor function;Reporting;Research;research study;response;reward processing;Rewards;Role;SB-334867;scaffold;Scanning;Self Administration;Shapes;Signal Transduction;Site-Directed Mutagenesis;Sleep Disorders;Sleeplessness;small molecule;Structure;Structure-Activity Relationship;System;Testing;Tetrahydroisoquinolines;therapy development;tool;Translating;Vertebral column;virtual;Work,Orexin-1 Receptor Ligands for Drug Addiction,32837,NSS,No Study Section (in-house review),,,3,499911,
8707587,D43,TW,5,N,02/01/2014,02/01/2014,01/31/2015,279,D43TW009586,SCHOOLS OF PUBLIC HEALTH,PAR-12-068,5D43TW009586-02,FIC:142246\NIDA:113000\,Other Research Related,2014,FOGARTY INTERNATIONAL CENTER,,LOS ANGELES,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,33,092530369,US,UNIVERSITY OF CALIFORNIA LOS ANGELES,CA,900952000,"PUBLIC HEALTH RELEVANCE: China has created a web-based real-time national HIV/AIDS information system that contains seven subsystems, including HIV/AIDS case management, antiretroviral therapy (ART), methadone maintenance therapy (MMT), voluntary counseling and HIV testing (VCT), and behavioral intervention targeting high-risk groups. Of these seven, three large databases are actually dynamic cohorts, namely HIV infection, ART, and MMT cohorts. An electronic file is created for each diagnosed HIV-infected individual. This HIV/AIDS case management subsystem contains 440,000 records of subjects, the national free ART subsystem covers 160,000 individuals, and the MMT database contains records of 340,000 opioid-dependent drug users receiving MMT. These enormous databases are essential for monitoring the national HIV/AIDS program and for future planning, but are under-utilized. Unless the data can be analyzed by competent health professionals, it will be useless. China does not have enough professionals skilled in analysis and interpretation of large datasets, even though analyzing this data is an essential priority for improving the national program. The UCLA/China CDC program proposes to meet this critical need for public health professionals who can implement evidence-based effective public health programs to control and manage the HIV/AIDS epidemic.",1871887 (contact);8120381;,"DETELS, ROGER  (contact);LI, LI;","MCDERMOTT, JEANNE ",08/01/2013,01/31/2018,AIDS/HIV problem;Centers for Disease Control and Prevention (U.S.);China;Chinese People;Data Analyses;Data Collection;data management;Data Set;Doctor of Philosophy;Educational workshop;Faculty;Health;HIV;HIV diagnosis;Institution;Intervention;Joints;Methodology;Monitor;Participant;Patients;Pharmaceutical Preparations;Policies;Positioning Attribute;programs;Public Health Schools;Publishing;Research;Research Methodology;Research Personnel;research study;Resources;Role;Series;Training;Training Programs;Work,UCLA/China CDC Training Program in Advanced Research Methodologies,9586,ZRG1,Special Emphasis Panel,,,2,255246,
8627478,F30,DA,5,N,01/23/2014,02/04/2014,02/03/2015,279,F30DA035065,SCHOOLS OF MEDICINE,PA-11-110,5F30DA035065-02,NIDA:42361\,"Training, Individual",2014,NATIONAL INSTITUTE ON DRUG ABUSE,,CHARLESTON,UNITED STATES,NEUROSCIENCES,06,183710748,US,MEDICAL UNIVERSITY OF SOUTH CAROLINA,SC,29425,"PUBLIC HEALTH RELEVANCE: Drug abuse remains a major public health issue, partly because a treatment that dampens motivation for drugs without dampening motivation for natural rewards such as food, relationships, etc. has remained elusive. These studies characterize the neural circuitry of a potential treatment for drug abuse that selectively reduces motivation for cocaine but not for food;hence, knowledge produced from these studies will support development for a human therapy for drug abuse.                ",10834835;,"BENTZLEY, BRANDON S;","BABECKI, BETH ",02/04/2013,02/03/2016,Abstinence;Achievement;Adverse effects;Agonist;Animals;base;Behavioral;Behavioral Paradigm;Biological Neural Networks;Brain;Clozapine;Cocaine;Cocaine Dependences;Coupled;Data;Deep Brain Stimulation;Designer Drugs;Development;Dose;Drug abuse;drug abuse therapy;Drug abuser;Drug Addiction;drug reward;Economics;Fellowship;Fiber;Food;Food Preferences;Future;Goals;Histologic;Human;hypocretin;Hypothalamic structure;Ibotenic Acid;Intake;Knowledge;Lateral;Lentivirus Vector;Lesion;Life;Measures;Mediating;Methods;Microinjections;Motivation;Muscimol;neural circuit;Neurons;non-drug;novel;orexin 1 receptor;orexin A;Oxides;Parkinson Disease;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacogenetics;Play;preference;Procedures;Promotor (Genetics);prospective;public health medicine (field);public health relevance;Rattus;receptor;relating to nervous system;Reporting;Research;research study;Rewards;Role;Self Administration;Self-Administered;Series;Structure of subthalamic nucleus;Sucrose;Techniques;Testing;Therapeutic Effect;therapy development;Training;Translating;Viral Vector,The Role of Orexin and Subthalamic Nucleus in Cocaine Demand,35065,ZRG1,Special Emphasis Panel,,,2,42361,
8603275,F30,HL,5,N,02/06/2014,02/01/2014,01/31/2015,837,F30HL107066,SCHOOLS OF MEDICINE,PA-09-232,5F30HL107066-03,NHLBI:47232\,"Training, Individual",2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212," The mechanism for atrial fibrillation (AF), the most common cardiac arrhythmia in adults, is poorly understood, and a better grasp of its molecular basis may lead to improved therapies and prevention. Because AF does not present during childhood, the combination of both genetic predisposition with factors acquired during life may underlie this disorder. These proposed studies will investigate the interaction between a causative AF mutation and oxidative stress, an established AF risk factor that increases with advancing age.            ",10431158;,"CAMPBELL, COURTNEY MICHELLE;","CARLSON, DREW E",02/01/2013,01/31/2016,acquired factor;Action Potentials;Acute;Adenoviruses;Adult;Affect;American;Arrhythmia;Atrial Fibrillation;base;Cardiac Myocytes;Cardiology;Cells;Characteristics;Childhood;clinical phenotype;Coupled;density;Disease;Doctor of Philosophy;Elderly;Electrophysiology (science);Etiology;Exposure to;Family;Frequencies (time pattern);gain of function;gain of function mutation;gene environment interaction;Gene Mutation;Genetic;Genetic Predisposition to Disease;Genetic Risk;Goals;grasp;Heart Atrium;Hydrogen Peroxide;improved;In Vitro;Lead;Life;Link;Mammalian Cell;Membrane;Molecular;Morphology;Muscle Cells;mutant;Mutation;Oryctolagus cuniculus;Oxidative Stress;Pathogenesis;Pharmacology;Physicians;Population;Potassium;Potassium Channel;pre-doctoral;Predisposition;Prevention therapy;Property;recombinant virus;Recombinants;Refractory;Relative (related person);Research;research study;Research Support;Risk;Risk Factors;Scientist;System;Testing;theories;Tissues;Training;Translating;Work,Mechanism of Atrial Fibrillation Susceptibility Due to Mutant Potassium Channels,107066,ZRG1,Special Emphasis Panel,,,3,47232,
8606769,F30,HL,5,N,02/07/2014,02/01/2014,01/31/2015,837,F30HL107092,SCHOOLS OF MEDICINE,PA-09-232,5F30HL107092-04,NHLBI:45068\,"Training, Individual",2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,NORTHWESTERN UNIVERSITY AT CHICAGO,IL,60611," Project Narrative Pseudomonas aeruginosa is an important bacterial pathogen responsible for a variety of healthcare-associated infections, notably ventilator-associated pneumonia. Our goal is to understand how P. aeruginosa impairs immune defenses to cause these severe infections of the lungs. This knowledge will aid the development of improved strategies in prevention, management, and treatment of pneumonia.",9723551;,"ZHANG, ANGELICA;","TIGNO, XENIA ",02/01/2011,01/31/2016,Acute;Acute Pneumonia;Alveolar Macrophages;Amoeba genus;Animal Model;Bacteria;Biological Assay;Bone Marrow Transplantation;cell type;Cells;Cessation of life;chemotherapeutic agent;Complex;cystic fibrosis patients;Cytolysis;Cytoplasm;cytotoxicity;Data;Development;Disease;Disease Progression;Engraftment;Epithelial Cells;Fibroblasts;Functional disorder;Goals;Gram-Negative Bacteria;Healthcare;Hematologic Neoplasms;Hour;Human;Immune;Immunocompromised Host;Impairment;improved;In Vitro;in vivo;Infection;Injection of therapeutic agent;Intoxication;Killings;Knowledge;Link;Lung;macrophage;mouse model;Mus;Neutropenia;neutrophil;Outcome;pathogen;Pathogenesis;Patients;Phagocytes;Phagocytosis;Phospholipase;Play;Pneumonia;Predisposition;Prevention;Property;Proteins;Pseudomonas;Pseudomonas aeruginosa;public health relevance;research study;Risk;Role;Severity of illness;Staging;stem;Surface;Syringes;System;Technology;Testing;therapeutic development;Toxin;Transgenic Mice;Type III Secretion System Pathway;Ventilator;Virulence;Yeasts,Phagocyte Intoxication by ExoU in Pseudomonas Pneumonia,107092,ZRG1,Special Emphasis Panel,,,4,45068,
8607588,F30,HL,5,N,01/16/2014,02/06/2014,02/05/2015,837,F30HL108590,GRADUATE SCHOOLS,PA-11-125,5F30HL108590-03,NHLBI:37954\,"Training, Individual",2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,GENETICS,07,039318308,US,TUFTS UNIVERSITY BOSTON,MA,02111,"Cardiovascular disease (CVD), including heart attacks, strokes, and aneurysms, remains the leading cause of death in America. This work focuses on understanding the mechanisms underlying blood vessel damage in CVD. The long-term goal is to design targeted therapies for the treatment of CVD.",10594493;,"AUSTIN, KARYN MARIE;","MEADOWS, TAWANNA ",02/06/2012,02/05/2017,Accounting;Acute;Agonist;Americas;Aneurysm;Angioplasty;Arterial Fatty Streak;Atherosclerosis;autocrine;base;Blood Vessels;Cardiovascular Diseases;Carotid Arteries;Cause of Death;cell behavior;Cell physiology;Cell Proliferation;Cells;Cessation of life;Characteristics;Chronic;Cleaved cell;Coronary;Coronary Arteriosclerosis;Data;design;Development;Disease;Endopeptidases;Ethnic group;Event;Extracellular Matrix Degradation;Family;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;improved;In Vitro;in vitro Assay;Inflammatory;Injury;injury and repair;interest;interstitial;Intervention;Knockout Mice;Lesion;Malignant Neoplasms;MAP Kinase Gene;Measures;Metabolic;Metalloproteases;migration;Modeling;Molecular;Morbidity - disease rate;Mortality Vital Statistics;mouse model;Mus;Myocardial Infarction;Nature;neointima formation;Outcome;PAR-1 Receptor;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;Phenotype;Physiological;Physiology;Plasma;Play;Population;pre-clinical;Prevention;Process;Production;Proliferating;Property;Protein C (activated);Publishing;Race;Relative (related person);repaired;Research;research study;response;restenosis;Role;Rupture;Sepsis;Signal Transduction;Site;Smooth Muscle Myocytes;Source;stroke;Testing;theories;Therapeutic;Thrombin;Thrombosis;Time;United States;Vascular remodeling;Work,The role of metalloprotease-PAR1 signaling in vascular injury and repair,108590,ZRG1,Special Emphasis Panel,,,3,37954,
8605502,F31,AI,5,N,01/16/2014,02/07/2014,02/06/2015,855,F31AI094972,SCHOOLS OF MEDICINE,PA-11-112,5F31AI094972-03,NIAID:38832\,"Training, Individual",2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW ORLEANS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,053785812,US,TULANE UNIVERSITY OF LOUISIANA,LA,70118,"Over the past fifty years, the incidence of Dengue fever (DF), caused by Dengue virus (DENV), and Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS), a potentially fatal complication of DF and a major cause of morbidity and mortality in children throughout the world, has increased 30-fold and has expanded into new parts of the world, including the United States, resulting in volatile outbreaks and making DENV a global public health problem. There are currently no treatments or vaccines available against DENV, and a limited understanding of the immune response to the virus coupled with the lack of suitable animal models to study the disease hinder the development of DENV antivirals and vaccines. The proposed research will study the human antibody response to DENV and utilize a new small animal model of DENV infection to gain a more complete understanding of the immune response to DENV and assess the ability to use antibodies for treatment or as tools to help develop vaccines.",10594281;,"BAZZONE, LINDSEY E;","ADGER-JOHNSON, DIANE S.",02/07/2012,02/06/2015,Animal Model;Antibodies;Antibody Formation;Antibody-Dependent Enhancement;Antigen-Presenting Cells;Antiviral Agents;base;Biological Assay;Blood Vessels;Cell Culture Techniques;cell type;Cessation of life;Child;Childhood;Clinical;Clinical Research;Complication;Coupled;Dendritic Cells;Dengue;Dengue Hemorrhagic Fever;Dengue Shock Syndrome;Dengue Virus;Development;Disease;Disease Outbreaks;Dyes;Electrical Resistance;Endothelial Cells;Endothelium;Enhancing Antibodies;Evans blue stain;Exhibits;Extravasation;Ferrets;Goals;Hemorrhagic Shock;Histocytochemistry;Human;human monoclonal antibodies;Immune;Immune response;Immunity;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;Individual;Infection;Inflammatory Response;Investigation;K562 Cells;Laboratories;Laboratory Study;macrophage;Measures;Mediating;Modeling;Morbidity - disease rate;Mortality Vital Statistics;novel;Pathogenesis;Pathology;Patients;Plaque Assay;Production;programs;public health medicine (field);Reagent;Research;Resources;Role;secondary infection;Serotyping;Syndrome;Testing;Tissues;Titrations;tool;United States;uptake;Vaccines;Vascular Permeabilities;Viral;Viral Antigens;Viral Genome;Viral load measurement;Viremia;Virus;Virus Diseases;virus pathogenesis;Virus Replication,The Effects of Antibodies on Vascular Permeability in Dengue Virus Infection,94972,ZRG1,Special Emphasis Panel,,,3,38832,
8607175,F31,DC,5,N,01/29/2014,02/08/2014,02/07/2015,173,F31DC012483,SCHOOLS OF MEDICINE,PA-11-111,5F31DC012483-03,NIDCD:34550\,"Training, Individual",2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CHICAGO,UNITED STATES,ANESTHESIOLOGY,07,005436803,US,NORTHWESTERN UNIVERSITY AT CHICAGO,IL,60611,"Currently, within the United States, 42,600 adults and 28,400 children have cochlear implants, which depend on the spiral ganglion neurons (SGNs) for conducting auditory information including human speech. Understanding how SGNs are generated and develop can inform methods for how to maintain the auditory nerve for optimal cochlear implant function. We believe that the transcription factor Insm1 promotes the production and differentiation of SGNs.",10796598;,"LORENZEN, SARAH M;","SKLARE, DAN ",02/08/2012,02/07/2015,Acoustic Nerve;Adrenal Glands;Adult;Apical;Apoptosis;Apoptotic;Attention;Auditory;Automobile Driving;base;Bromodeoxyuridine;Cell Death;cell injury;Cells;Child;Cleaved cell;Cochlear Implants;Commit;Development;Ear structure;Ectopic Expression;Electroporation;Embryo;Embryonic Development;Ganglia;Genes;Hair Cells;Hearing;Human;Immunohistochemistry;improved;In Situ Hybridization;in utero;Knock-out;Knockout Mice;Label;Medicine;Messenger RNA;Methods;Mus;nerve stem cell;Nervous system structure;Neurites;neurofilament;neurogenesis;neuron development;Neurons;novel;Olfactory Epithelium;otoconia;Patients;Pattern;Phenotype;Play;postnatal;Process;Production;progenitor;Proliferating;Proliferation Marker;Role;spatiotemporal;Speech;spiral ganglion;Staging;Staining method;Stains;Stem cells;Techniques;Testing;Time;tool;transcription factor;transcriptome sequencing;United States;Vestibular ganglion;Zinc Fingers,Insm1 in Development of Spiral and Vestibular Ganglia,12483,CDRC,Communication Disorders Review Committee,,,3,34550,
8634136,F31,HL,5,N,01/06/2014,02/02/2014,02/01/2015,837,F31HL096406,SCHOOLS OF MEDICINE,PA-07-106,5F31HL096406-05,NHLBI:42232\,"Training, Individual",2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,110521739,US,ALBERT EINSTEIN COLLEGE OF MEDICINE,NY,10461,,9563772;,"SARRAN, LISA ANN MARIE;","WELNIAK, LISBETH A",02/02/2010,02/01/2015,"Adult;Animals;Apoptosis;CASP8 gene;cell type;Cells;Dependence;Development;Embryo;embryonic stem cell;Endothelium;Erythrocytes;Failure (biologic function);fetal;Generic Drugs;Genetic Recombination;Globin;Goals;Gonadal structure;Health;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hemoglobin;Human;human embryonic stem cell;In Vitro;in vivo;Lead;Mediating;Medical;Mesoderm Cell;Methods;Mission;Mus;National Heart, Lung, and Blood Institute;Patients;Phenotype;Procedures;Production;Promotor (Genetics);Protocols documentation;public health medicine (field);Research;Research Personnel;RNA Interference;Serum;Signal Transduction;Signaling Molecule;Source;stem cell differentiation;stem cell niche;System;Tacrolimus Binding Proteins;Technology;Testing;Therapeutic;Tissues;transcription factor;Transgenes;Transplantation;United States National Institutes of Health",The Production of Adult Red Blood Cells from Human Embryonic Stem Cells,96406,ZRG1,Special Emphasis Panel,,,5,42232,
8597967,F31,NR,5,N,02/06/2014,02/07/2014,02/28/2014,361,F31NR013306,SCHOOLS OF NURSING,PAR-11-117,5F31NR013306-03,NINR:6572\,"Training, Individual",2014,NATIONAL INSTITUTE OF NURSING RESEARCH,,PHILADELPHIA,UNITED STATES,NONE,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"I plan to focus my pre-doctoral training on becoming an independent nurse research investigator, and the research component of my pre-doctoral fellowship focuses on the interruption of goal-direct behavior in patients with neurodegenerative disease, leading to a profound form of apathy that is associated with increased morbidity and mortality. Although this significant problem is commonly observed in patients and has a pervasive impact on caregivers, the mechanisms underlying apathy have not been well studied. The proposed work will dissect apathy quantitatively, providing both behavioral and neuroanatomical insight into the basis for this condition, and this will lead to effective interventions aimed at treating the specific dysfunctions contributing to apathy.",10520314;,"MASSIMO, LAUREN M;","BANKS, DAVID ",01/01/2012,02/28/2014,Advanced Practice Nurse;Anatomy;Anterior;Area;base;Behavior;Behavioral;Behavioral Symptoms;Belief;Biological;Brain;Brain imaging;Caregiver Burden;Caregivers;Cessation of life;cingulate cortex;Cognitive;computerized;Corpus striatum structure;Data;Databases;diagnostic accuracy;Disease;effective intervention;effective therapy;Emotions;experience;Family Caregiver;Family Nursing;Fellowship;frontal lobe;Frontotemporal Dementia;Functional disorder;Geriatric Nursing;Goals;Health Professional;Human;illness length;Impairment;improved;Individual National Research Service Award;innovation;insight;Interruption;Intervention;Knowledge;Laboratory Study;Lead;Literature;Magnetic Resonance Imaging;Medial;Modeling;Morbidity - disease rate;Mortality Vital Statistics;Motivation;National Institute of Nursing Research;National Research Service Awards;neurobehavioral;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurological Nursing;Neurologist;neuron loss;neuropsychiatry;neuropsychological;Neurosciences;novel;Nurses;Nursing Research;Outcome;Pain;Patients;Philadelphia;Physiological;pre-doctoral;Prefrontal Cortex;Process;Quality of life;Reaction Time;relating to nervous system;Reporting;Research;Research Personnel;Research Priority;Research Proposals;Research Training;response;Rewards;Risk;Scientist;skills;Social Behavior;social neuroscience;Staging;Strategic Planning;Symptoms;Syndrome;System;Task Performances;Temporal Lobe;Testing;tool;Training;Variant;Work,The Cognitive and Neural Basis of Apathy in Frontotemporal Degeneration,13306,NRRC,Nursing Science Review Committee,,,3,6572,
8600166,F32,DC,5,N,02/07/2014,02/01/2014,01/31/2015,173,F32DC013207,UNIVERSITY-WIDE,PA-11-113,5F32DC013207-02,NIDCD:52190\,"Training, Individual",2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PITTSBURGH,UNITED STATES,NONE,14,004514360,US,UNIVERSITY OF PITTSBURGH,PA,15213,"PUBLIC HEALTH RELEVANCE: The neurons of the lateral superior olive (LSO) in the brainstem receive information from the two ears, which allows them to compute the location from which sound originates in space. This requires very precise patterning of inputs from neurons from the two ears. Study of the development of these patterns and the neurotransmitters involved is important for determining how normal hearing occurs, and in identification of potential targets for therapeutics in cases in which hearing is impaired due to genetics, disease, or injury.                ",10128951;,"WEISZ, CATHERINE JEANNE CHALENSKI;","SKLARE, DAN ",02/01/2013,01/31/2015,Action Potentials;age related;Animals;Area;Auditory;Axon;Brain;Brain region;Brain Stem;Calcium;Calcium Signaling;cell body (neuron);Cell Nucleus;Cells;Characteristics;Cochlear nucleus structure;Contralateral;Detection;Development;Ear structure;Electron Microscopy;Electrophysiology (science);Fluorescent Dyes;Frequencies (time pattern);GABA Receptor;GABA-A Receptor;gamma-Aminobutyric Acid;Generations;Glutamates;Glycine;Head;Hearing;Hearing problem;Hereditary Disease;Human;Image;Imaging Techniques;Individual;Injury;insight;Investigation;Ipsilateral;Lasers;lateral superior olive;Light;Location;Measures;Medial;Mediating;Mus;neuron development;Neurons;neurotransmitter release;Neurotransmitters;novel;optogenetics;Pathway interactions;Pattern;Photons;Physiologic pulse;Population;postnatal;postsynaptic;presynaptic;Presynaptic Receptors;Presynaptic Terminals;Probability;Process;Promotor (Genetics);public health relevance;receptor;Receptor Activation;Research;research study;response;Rodent;Role;Signal Transduction;Slice;sound;Sound Localization;Staging;Stereotyping;Stimulus;Structure of trapezoid body;Subcellular structure;Synapses;synaptogenesis;Techniques;Testing;therapeutic target;Time;tool;vesicular GABA transporter;Whole-Cell Recordings,Presynaptic GABA-A receptor activation in auditory brainstem axon terminals,13207,ZDC1,Special Emphasis Panel,,,2,52190,
8606750,F32,GM,5,N,02/06/2014,02/01/2014,01/31/2015,859,F32GM100611,SCHOOLS OF MEDICINE,PA-11-113,5F32GM100611-03,NIGMS:53942\,"Training, Individual",2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,PHARMACOLOGY,12,094878337,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"We propose to globally identify RNAP pause sites in vivo with single-nucleotide resolution, and to use this information to determine the role of transcriptional pausing in live organisms. These genome-wide data will provide unique insight into coupling between transcription and translation in bacteria, which is a key antibiotic target. Furthermore, the methods developed will be directly applicable to studies of cancer-causing bacteria like Helicobacter pylori and Chlamydia trachomatis, as well human cancer cells, where defects in transcription often lead to activation of genes involved in tumor growth and silencing of genes associated with tumor suppression.",10866692;,"LARSON, MATTHEW HERBERT;","REDDY, MICHAEL K.",02/01/2012,01/31/2015,Affect;Antibiotics;Automobile Driving;Bacteria;Bacterial Genome;Bacterial RNA;Behavior;Biochemical;Bioinformatics;Biological Assay;cancer cell;Cancer Etiology;carcinogenesis;Cell physiology;Cells;Chlamydia trachomatis;Coupling;Data;deep sequencing;Defect;DNA;DNA Library;DNA-Directed RNA Polymerase;Environment;Escherichia coli;Event;Frequencies (time pattern);Gene Activation;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genetic;Genetic Transcription;Genetic Translation;Genome;genome-wide;Goals;Helicobacter pylori;Human;In Vitro;in vivo;insight;Lead;Life;Link;Malignant Neoplasms;Maps;Measurement;Mediating;Messenger RNA;Methodology;Methods;Modeling;Molecular;Monitor;mutant;Mutation;novel;Nucleotides;Organism;pathogenic bacteria;Play;Positioning Attribute;Prevalence;Process;Production;protein complex;Proteins;Protocols documentation;research study;Resolution;Resources;Ribosomes;RNA;RNA chemical synthesis;RNA Processing;RNA Splicing;Role;Site;Structure;Techniques;Testing;tool;Transcript;transcription factor;Translation Initiation;Translations;tumor growth;Tumor Suppression;Wit;Yeasts,In vivo observations of transcription at single-nucleotide resolution,100611,ZRG1,Special Emphasis Panel,,,3,53942,
8608608,F32,NS,5,N,01/30/2014,02/06/2014,02/05/2015,853,F32NS074758,SCHOOLS OF MEDICINE,PA-11-113,5F32NS074758-03,NINDS:55670\,"Training, Individual",2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,PEDIATRICS,11,077758407,US,CASE WESTERN RESERVE UNIVERSITY,OH,441067015,"Many different human conditions affect our ability to sense and respond to the world around us. Treatment of these conditions hinges on understanding their pathogenesis, which can only come from understanding the development and maintenance of the somatosensory system. This project addresses the development of the neurons responsible for relaying information regarding curvature, shape, and texture from the skin to the spinal cord. We expect our studies to elucidate general mechanisms controlling sensory neuron development and function and to provide a structure upon which to understand derangements of neuronal development and survival that occur in human disease.",8623288;,"REED-GEAGHAN, ERIN G;","RIDDLE, ROBERT D.",02/06/2012,02/05/2015,Address;Adolescent;Affect;afferent nerve;Afferent Neurons;Animal Model;Animals;Autoimmune Diseases;Biological Models;Brain-Derived Neurotrophic Factor;Cell Differentiation process;Cells;Characteristics;Complex;Cutaneous;Data;Defect;Demyelinating Diseases;Dermal;design;Detection;Development;Discrimination (Psychology);Dorsal;Exhibits;Family;Fiber;foot;Gene Expression;Gene Expression Microarray Analysis;Genes;Genetic;Goals;Growth Factor;Hand;Human;human disease;Immunohistochemistry;Infection;information processing;Injury;insight;Laboratories;Ligands;Maintenance;Mechanoreceptors;Mediating;Merkel Cells;Metabolic Diseases;Molecular;Molecular Abnormality;Morphology;mouse model;Mus;Nature;Nerve Fibers;Nerve Growth Factor Receptors;nerve supply;Neural Crest Cell;Neural tube;Neurites;neuron development;neuronal survival;Neurons;neurotrophic factor;Neurotrophin 3;novel strategies;Organism;Pain;Pathogenesis;Pathway interactions;Pattern;Perception;Peripheral;Phenotype;Play;Population;Positioning Attribute;postnatal;pressure;Process;receptor;receptor expression;research study;response;Role;Shapes;Signal Transduction;Skin;somatosensory;Source;Specific qualifier value;Spinal Cord;Spinal Ganglia;Structure;System;Temperature;Texture;Touch sensation;Toxicant exposure;transcription factor;transdifferentiation;Vascular Diseases;Vibrissae,Merkel cells specify innervating SAI sensory neuron phenotype.,74758,ZRG1,Special Emphasis Panel,,,3,55670,
8625178,I01,VA,5,N,02/07/2014,01/01/2014,12/31/2014,999,I01BX000993,,RFA-BX-12-001,5I01BX000993-02,,Research Projects,2014,Veterans Affairs,,PITTSBURGH,UNITED STATES,,14,033127569,US,VETERANS HEALTH ADMINISTRATION,PA,15206,"PUBLIC HEALTH RELEVANCE:         Lung cancer (LC) affects more than 200,000 people and accounts for more than 160,000 deaths per year in the US. LC is almost twice more frequent in war veterans than in general population, due to their prolonged and intensive exposure to carcinogens and stress. This project proposes to investigate new cancer biomarkers for early detection and prognosis of LC. Such biomarkers would help clinicians to detect the early, asymptomatic stage LC in high risk populations such as veterans and enable an efficient and economical treatment of LC at its early/curable stages;and to develop personalized therapy planning for and selectively and economically apply adjuvant therapy to veteran LC patients with aggressive cancer who would benefit from therapy.                ",1893014;,"VUJANOVIC, NIKOLA LAZAR;",,01/01/2013,12/31/2015,Ablation;Accounting;Adjuvant Therapy;Affect;Attention;base;Biological Assay;Biological Markers;Blood;Cancer Etiology;Cancer Patient;Cancer Prognosis;cancer recurrence;Carcinogens;Cell physiology;Cells;Cessation of life;Chronic Obstructive Airway Disease;Clinical;Complex Mixtures;conventional therapy;Data;Development;Diagnosis;Disease;Disease Outcome;Early Diagnosis;Early treatment;enzyme activity;Enzyme Gene;Enzymes;Exposure to;Gene Expression;General Population;Genes;Goals;Growth;Head and Neck Cancer;Hematopoietic Neoplasms;high risk;Inflammation;Inflammatory;interstitial;Investigation;Laboratories;Lead;Lung;Lung diseases;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;Mediating;Mediator of activation protein;Methods;Military Personnel;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;Non-smoker;novel;Operative Surgical Procedures;Oral mucous membrane structure;Outcome;outcome forecast;Patients;Peptides;peripheral blood;Population;Primary Neoplasm;protein expression;Proteins;public health relevance;Recurrence;Relative (related person);Role;screening;Screening for Lung Cancer;Smoker;Staging;Stress;Structure of parenchyma of lung;Testing;Time;Tissues;Tumor Tissue;Up-Regulation (Physiology);Veterans;War,Defining ADAM Sheddase Activities as Lung Cancer Biomarkers,993,ONCA,Oncology A,,,2,,
8244940,I01,VA,5,N,02/07/2014,10/01/2013,06/30/2014,999,I01BX001151,,RFA-BX-10-006,5I01BX001151-02,,Research Projects,2014,Veterans Affairs,,ALBUQUERQUE,UNITED STATES,,01,073242369,US,ALBUQUERQUE VA MEDICAL CENTER,NM,87108,"Narrative Defective intestinal barrier or leaky gut allows bacterial antigens in the gut to be absorbed and induce inflammatory response. In wide variety of diseases, absorbed bacterial antigens reach systemic circulation and induce systemic inflammatory reaction, leading to multi-organ failure or death. Gut- derived bacterial antigens are important mediators of intestinal and systemic inflammatory response. The purpose of this grant application is to elucidate the pathogenic mechanisms involved in bacterial antigen induced disruption of intestinal barrier (or development of leaky gut).",1935137;,"MA, THOMAS Y;",,04/01/2011,06/30/2016,abstracting;acute pancreatitis;Adult Respiratory Distress Syndrome;Alcoholic Liver Diseases;Antigens;Apoptosis;Applications Grants;Bacterial Antigens;base;Biological Models;Blood Circulation;Body Weight;Catalytic Domain;Celiac Disease;Cell Death;Cessation of life;Critical Illness;Crohn's disease;Data;Development;Disease;Endotoxins;enteritis;Enterocytes;Epithelial;Epithelial Cells;Funding;gastrointestinal;Gene Expression;Genes;Goals;Heat Stroke;Hemorrhagic Shock;In Vitro;in vitro Model;in vivo;Inflammatory;Inflammatory disease of the intestine;Inflammatory Response;Intestines;intraperitoneal;knock-down;Laboratory Research;Lateral;Lipopolysaccharides;MAPK14 gene;Mediating;Mediator of activation protein;Membrane;Molecular;monolayer;mouse model;mRNA Expression;Mus;Myosin Light Chain Kinase;Necrotizing Enterocolitis;Non-Steroidal Anti-Inflammatory Agents;Organ;Organ failure;Pathogenesis;Pathway interactions;Perfusion;Permeability;Phosphotransferases;Physiological;Physiology;Play;prevent;Process;protein expression;Reaction;Recycling;Regulation;Research;Role;seal;Services;Signal Transduction;Signal Transduction Pathway;Small Interfering RNA;Stream;Syndrome;Systemic disease;Testing;Therapeutic;Tight Junctions;Time;Tissues;toll-like receptor 4;Ulcerative Colitis;Up-Regulation (Physiology),Regulation of Intestinal Epithelial Tight Junction Barrier,1151,GAST,Gastroenterology,,,2,,
8597917,I01,VA,5,N,02/07/2014,10/01/2013,09/30/2014,999,I01BX001193,,RFA-BX-11-014,5I01BX001193-02,,Research Projects,2014,Veterans Affairs,,MEMPHIS,UNITED STATES,,09,078577285,US,MEMPHIS VA MEDICAL CENTER,TN,38104,"This is a research project that experimentally determines the roles played by regulatory T cells (Tregs) in regulating the development of inflammatory arthritis. Lineage, mechanism of action and phenotypic and functional stability are addressed.",1943097;,"BRAND, DAVID DOUGLASS;",,10/01/2012,09/30/2016,Address;Affect;Animal Model;Antigens;Arthritis;autoimmune arthritis;Autoimmune Diseases;Autoimmune Process;Autoimmune Responses;Autoimmunity;base;bone;Cartilage;cell type;Cells;Characteristics;Clinic;Collagen;Collagen Arthritis;Complement Factor B;Complex;design;Development;Disease;Disease remission;Employee Strikes;Etiology;Exposure to;Green Fluorescent Proteins;Homeostasis;Human;human leukocyte antigen gene;Immune;Immune response;Immune system;immunoregulation;In Vitro;in vivo;in vivo Model;Inflammation;Inflammation Mediators;Inflammatory;interest;Interleukin-17;Interleukin-6;Interruption;joint function;joint injury;Joints;Label;Ligands;lymph nodes;Measures;Mediating;Modality;Modeling;Mus;Nature;novel therapeutic intervention;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Play;Population;precursor cell;Predisposition;prevent;Prevention;Process;Promotor (Genetics);Quality of life;Reaction;red fluorescent protein;Regulation;Regulatory T-Lymphocyte;Reporter;Research;Research Project Grants;Resistance;response;Rheumatoid Arthritis;Role;Severities;Signal Transduction;Synovial Fluid;System;T-Lymphocyte;Therapeutic;tool;Transforming Growth Factors;Transgenic Organisms;Translating;Veterans;Work,Regulatory Mechanisms in Autoimmune Arthritis,1193,IMMA,Immunology and Dermatology A,,,2,,
8536077,I01,VA,5,N,02/07/2014,07/01/2013,06/30/2014,999,I01BX001242,,RFA-BX-11-001,5I01BX001242-02,,Research Projects,2014,Veterans Affairs,,WASHINGTON,UNITED STATES,,00,129913026,US,U.S. DEPT/VETS AFFAIRS MEDICAL CENTER,DC,20422,"Bipolar disorder (BP) is a potentially devastating neuropsychiatric illness. There are an estimated 90,000 patients with BP in the VA system nationwide. There are currently no specific genetic sequence changes (mutations) known to cause illness across various ethnic groups, and a large proportion of patients do not respond to treatment adequately. Recently, we have developed the capacity to sequence the entire genomes of individuals. Finding potentially rare sequence changes that might cause the illness is a new and potentially powerful means to isolating the genetic risk factors for this illness. The identification of such mutations may provide vital clues to understanding not only the causes of the illness, but also to developing new treatments. In this project, we seek to determine the sequences of the entire genomes of individuals with BP and search for both common and rare mutations. We will then test the mutations that we discover in very large population- based samples.",6869734;,"FANOUS, AYMAN H;",,07/01/2012,06/30/2016,Affect;Algorithms;base;Binding Sites;Bioinformatics;Bipolar Disorder;Clinical assessments;cohort;Complex;Data;Data Set;Databases;density;disability;Disease;DNA;DNA Sequence;Ethnic group;Family;Generations;Genes;Genetic;Genetic Risk;genetic risk factor;genetic variant;Genome;genome sequencing;genome wide association study;Genomics;Individual;Laboratories;Link;Methods;MicroRNAs;Mutation;National Institute of Mental Health (U.S.);neuropsychiatry;next generation sequencing;novel;Patients;population based;Promoter Regions (Genetics);Psychiatry;Publishing;Reading;Reporting;Research;Rest;Risk;risk variant;Sampling;Siblings;System;Technology;Testing;Time;transcription factor;Variant;Variation (Genetics);Veterans;Work,Convergent Genetic and Genomic Analyses of Bipolar Disorder,1242,MHBA,Mental Health and Behavioral Science A,,,2,,
8609068,K01,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,K01MH087889,SCHOOLS OF MEDICINE,PA-09-040,5K01MH087889-05,NIMH:170044\,Other Research Related,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,LA JOLLA,UNITED STATES,PSYCHIATRY,52,804355790,US,UNIVERSITY OF CALIFORNIA SAN DIEGO,CA,920930934," RESEARCH &RELATED - OTHER PROJECT INFORMATION 7. PROJECT NARRATIVE Psychiatric disorders, such as schizophrenia and bipolar disorder, exhibit genetic and clinical complexity and show a large degree of overlap. Defining the neurobiological bases of these debilitating disorders will require an interdisciplinary convergent neurobiological approach that will integrate clinical information with cutting edge neuroscience and genomic methods. Building on her existing knowledge of molecular biology and statistical genetics with training in clinical psychopathology, neurobiology, biomarkers, and functional outcomes, the candidate will be in a unique position to tackle these important questions in the near future.",2081272;,"GREENWOOD, TIFFANY A;","ROSEMOND, ERICA K",03/17/2010,01/31/2015,Address;Animal Model;Award;base;Biological Markers;Bipolar Disorder;career development;Clinical;Collaborations;Complement;Data;Data Analyses;Data Set;Databases;Diagnostic;Disease;Environment;Epidemiology;Exhibits;functional outcomes;Funding;Future;Genetic;Genetic Determinism;genetic risk factor;Genomics;Goals;Graduate Education;Interview;K-Series Research Career Programs;Knowledge;Laboratories;Lead;Link;Mental disorders;Mentors;Methodology;Methods;Molecular Biology;Molecular Genetics;National Institute of Mental Health (U.S.);Neurobiology;Neurosciences;Pathway interactions;Patients;Positioning Attribute;Predisposition;programs;psychogenetics;Psychopathology;public health relevance;Research;Research Personnel;Research Project Grants;Sampling;Schizophrenia;skills;Structure;Testing;Training;translational neuroscience;Variation (Genetics),The Convergence and Divergence of Schizophrenia and Bipolar Disorder,87889,GHD,Genetics of Health and Disease Study Section,,,5,170044,
8606719,K02,AA,5,N,02/05/2014,02/01/2014,01/31/2015,273,K02AA018755,SCHOOLS OF MEDICINE,PA-09-038,5K02AA018755-05,NIAAA:112319\,Other Research Related,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,RICHMOND,UNITED STATES,PSYCHIATRY,03,105300446,US,VIRGINIA COMMONWEALTH UNIVERSITY,VA,232980568,"PUBLIC HEALTH RELEVANCE:   The complexity of the genetics of alcohol dependence necessitates a variety of research approaches. This project integrates analyses from twin studies, used to characterize the nature of genetic influences on alcohol- related phenotypes;molecular genetic studies, aimed at gene identification;and community-based samples, used to characterize the risk associated with specific genes across development and as a function of the environment. Understanding how genetic and environmental factors interact across development will be critical to develop more effective, tailored programs of prevention and intervention.         ",6772116;,"DICK, DANIELLE M;","PARSIAN, ABBAS ",02/01/2010,01/31/2015,addiction;Address;Adolescence;adolescent substance use;Adult;Affect;African American;Age;Aggressive behavior;Alabama;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol misuse;Alcohol or Other Drugs use;alcohol related problem;alcohol research;alcohol use disorder;Alcohols;anti social;Architecture;Area;Attention deficit hyperactivity disorder;base;Behavior;Behavioral;career;career development;Characteristics;Child;Child Development;Childhood;clinical Diagnosis;Cognitive;cohesion;cohort;Communities;Complex;Conduct Disorder;conduct problem;Data;Data Analyses;Data Collection;Dependence;design;Development;Development Plans;deviant;Diagnosis;Disease;early childhood;early onset substance use;Enrollment;Environment;Environmental Risk Factor;Epidemiology;externalizing behavior;Funding;General Population;Genes;Genetic;genetic analysis;genetic association;genetics of alcoholism;genome wide association study;Genotype;Goals;high risk;high school;Home environment;Impulsivity;Independent Scientist Award;indexing;Individual;Interview;Longitudinal Studies;Measures;Methodology;Minority;Molecular;Molecular Genetics;Mothers;National Institute on Alcohol Abuse and Alcoholism;Nature;Neighborhoods;Oppositional Defiant Disorder;Parent-Child Relations;parental monitoring;Parenting behavior;Parents;Pathway interactions;Pattern;peer;Peer Group;Peer Review;Phenotype;Population;population based;pregnant;Preventive Intervention;Problem behavior;programs;pubertal timing;public health relevance;racial difference;Request for Applications;Research;research and development;Research Design;Research Project Grants;Research Support;Risk;Risk Factors;Role;Sales;Sampling;self esteem;Social support;stem;Structure;Substance Use Disorder;Susceptibility Gene;Symptoms;teacher;Temperament;Testing;Time;trait;Twin Multiple Birth;Twin Studies;underage drinking;Virginia;young adult;Youth,"Twin, molecular, and developmental approaches to understanding alcohol misuse",18755,AA,Biomedical Research Review Subcommittee,,,5,112319,
8607580,K08,HD,5,N,02/05/2014,02/01/2014,01/31/2015,865,K08HD067295,SCHOOLS OF MEDICINE,PA-10-059,5K08HD067295-04,NICHD:125685\,Other Research Related,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,SAN FRANCISCO,UNITED STATES,PEDIATRICS,12,094878337,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962," PROJECT NARRATIVE Even in the era of widespread childhood vaccination, infection in the newborn period remains a leading cause of neonatal death and disease, and represents a significant public health burden due to long-term disabilities that can result from it. The unique nature of the human fetal and newborn immune system causes it to respond weakly to immunization and infections, a phenomenon that is poorly understood and greatly understudied. Defining the factors behind this weak immune response will help to alleviate the burden of neonatal infectious disease by leading to the creation of better vaccines and treatments, tailored to the newborn immune system, that will reduce the frequency and severity of infections in the newborn.",10395516;,"BURT, TREVOR DEON;","GRAVE, GILMAN D.",02/10/2011,01/31/2016,Address;Admixture;Adult;Affect;Antibodies;Antigens;Applications Grants;Award;base;Basic Science;Birth;Bone Marrow;California;career;CD34 gene;CD4 Positive T Lymphocytes;Cells;Cellular biology;Characteristics;Childhood;Clinical;Clinical Research;Communicable Diseases;cytokine;Data;design;Development;disability;Discipline of obstetrics;Disease;Ensure;Environment;fetal;Fetal Liver;Fetus;Flow Cytometry;Frequencies (time pattern);Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Growth;Gynecology;Hematopoietic;Hepatitis B Vaccination;Human;Human Characteristics;Human Development;human stem cells;immune function;Immune response;Immune system;Immunity;Immunization;Immunologic Memory;Immunologics;Immunology;In Vitro;in vivo;Infant;Infection;Knowledge;Laboratories;Lead;Life;Measurement;Measures;Mediating;Medicine;Mentors;Messenger RNA;Molecular Profiling;Nature;Neonatal;neonatal death;neonate;Neonatology;Newborn Infant;Normal Range;Outcome;pathogen;Pathology;patient oriented;patient oriented research;Pediatrics;Phenotype;Play;Population;Predisposition;Pregnancy;Prevention strategy;Process;professor;progenitor;public health medicine (field);public health relevance;Publishing;Regulation;Regulatory T-Lymphocyte;Relative (related person);reproductive;Research;Research Personnel;Resources;response;Reverse Transcriptase Polymerase Chain Reaction;Sampling;San Francisco;Science;Severities;skills;Source;stem;stem cell biology;Stem cells;Stimulus;T cell response;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;Time;Translational Research;Umbilical Cord Blood;Universities;Vaccination;Vaccines;Variant, Defining Transition from Fetal to Adult T Cell Predominance in the Human Fetus ,67295,CHHD,Developmental Biology Subcommittee,,,4,125685,
8611897,K22,AI,5,N,02/07/2014,02/01/2014,01/31/2015,855,K22AI098440,SCHOOLS OF PHARMACY,PAR-09-068,5K22AI098440-02,NIAID:108000\,Other Research Related,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,PHARMACOLOGY,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472,"Public Health Relevance Statement (provided by the applicant): During HIV infection, there is massive dysfunction of the mucosal immune system that is associated with progression to AIDS, and the proposed studies are to determine the kinetics and mechanisms of this dysfunction after SIV infection. These studies will be essential to understand better how damage occurs in mucosal tissues during SIV infection in order to develop more effective therapeutic approaches aimed at treating HIV and AIDS.            ",10910075;,"KLATT, NICHOLE ROSE;","SHARMA, OPENDRA K.",02/04/2013,01/31/2015,Acquired Immunodeficiency Syndrome;Acute;Address;Anti-Bacterial Agents;Apoptosis;arm;Bacteria;base;Biological Preservation;Blood Circulation;CD4 Positive T Lymphocytes;Cell physiology;Cells;Cessation of life;Coculture Techniques;cytokine;Defensins;Dendritic Cells;Disease;Disease Progression;Environment;Epithelial;Epithelium;Event;exhaustion;extracellular;Flow Cytometry;Frequencies (time pattern);Functional disorder;fungus;gastrointestinal;Gastrointestinal tract structure;HIV;Home environment;Homeostasis;Homing;Immune;immune activation;immune function;Immune system;Immune System and Related Disorders;Immune System Diseases;Immunohistochemistry;In Vitro;in vivo;Individual;Infection;Inflammation;insight;Interleukin-17;interleukin-22;Intestinal Mucosa;Intestines;Kinetics;Lymphocyte;Lymphocyte Function;Macaca mulatta;Maintenance;microbial;Mucosal Immunity;Mucous Membrane;novel therapeutics;Production;Proliferating;Proliferation Marker;public health relevance;Relative (related person);response;SIV;System;Testing;Therapeutic;Time;treatment strategy;Virus Diseases;Virus Replication,Mucosal Immune Dysfunction after SIV Infection,98440,AIDS,Acquired Immunodeficiency Syndrome Research Review Committee,,,2,108000,
8600236,K23,AI,5,N,02/05/2014,01/01/2014,12/31/2014,855,K23AI091869,SCHOOLS OF MEDICINE,PA-10-060,5K23AI091869-04,NIAID:134325\,Other Research Related,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PEDIATRICS,03,001910777,US,JOHNS HOPKINS UNIVERSITY,MD,21218," Food allergy and eosinophilic esophagitis have become increasingly common clinical problems for which there is no known cure. We have recently identified the TGF pathway to be specifically involved in the development of these disorders. In this proposal, we will seek to understand the mechanism by which alterations in TGF signaling predispose to allergic disease, and how these pathways might be manipulated for therapeutic benefit.",8727520;,"GUERRERIO, PAMELA ANN;","PROGRAIS, LAWRENCE J.",01/01/2011,12/31/2015,Affect;Age;Allergic Disease;Allergy to peanuts;Antigens;Aortic Aneurysm;Asthma;Attenuated;base;Basic Science;Basophils;Biochemical;Biological Assay;Biological Models;Bone Marrow;Cardiovascular system;career;career development;Cell Count;cell type;Cellular Assay;Child;Clinical;cohort;Commit;craniofacial;cytokine;Data;Defect;Dendritic Cells;design;Development;Disease;Disease model;Disease Pathway;Eczema;effective therapy;Effector Cell;Eosinophilia;Eosinophilic Esophagitis;Etiology;Event;Exclusion;Exhibits;experience;Faculty;FDA approved;Fellowship;Five-Year Plans;food environment;Food Hypersensitivity;Foundations;Funding;Gene Expression;Genetic;Genetic Medicine;Genomics;Goals;Grant;High Prevalence;Homeostasis;Human;human subject;Hypersensitivity;IgE;Immune;Immune system;Immunity;Immunohistochemistry;Immunologics;Immunology;In Vitro;in vivo;in vivo Model;Individual;Institutes;interest;Investigation;K-Series Research Career Programs;Knock-in Mouse;Knowledge;Lead;Loeys-Dietz Syndrome;Losartan;Lymphocyte;Mediating;Medical;Medicine;Mentors;Mentorship;Modeling;Molecular Biology;mouse model;mRNA Decay;Mus;Mutate;Mutation;Nonsense-Mediated Decay;novel;Pathogenesis;Pathway interactions;Patients;Pediatrics;Peripheral;peripheral blood;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;Population;Positioning Attribute;Predisposition;Prevalence;Principal Investigator;Process;professor;Public Health Schools;Publications;receptor;Regulatory T-Lymphocyte;Research;research and development;Research Personnel;Residencies;Resources;response;RNA;RNA Stability;Role;Schools;Scientist;Secure;Series;Severities;Signal Pathway;Signal Transduction;Skeletal Development;skills;skills training;Syndrome;T-Cell Development;T-Lymphocyte;Testing;TGFBR1 gene;TGFBR2 gene;Therapeutic;Thymus Gland;Time;Training;Training Programs;Transforming Growth Factor beta;United States National Institutes of Health;Universities;Wood material;Work,Investigation of the Role of TGF Beta  in TH2-Mediated Disease,91869,AITC,Transplantation Biology &Immunology-2,,,4,134325,
8605517,K23,AI,5,N,02/05/2014,02/01/2014,01/31/2015,855,K23AI104779,SCHOOLS OF MEDICINE,PA-11-194,5K23AI104779-02,NIAID:172098\,Other Research Related,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NASHVILLE,UNITED STATES,PEDIATRICS,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212,"PROJECT NARRATIVE: This proposal seeks to better understand determinants of disease severity for children with pneumonia, the leading killer of children worldwide and the most common reason for childhood hospitalization in the United States. Knowledge of these factors and their often complex interactions will be used to predict risk for severe outcomes among children hospitalized with pneumonia, and could be applied in clinical settings to improve care and outcomes for this population.                ",9589436;,"WILLIAMS, DEREK J.;","TAYLOR, CHRISTOPHER E.,",02/01/2013,01/31/2017,5 year old;Accident and Emergency department;Admission activity;Adult;antimicrobial;Area;Award;base;Biometry;career;career development;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Child;Childhood;Cities;Clinical;clinical application;clinical care;clinical decision-making;Clinical Investigator;Clinical Research;Clinical Trials;cohort;Communicable Diseases;Communities;Complex;cost;cost effectiveness;Data;Data Sources;Decision Making;Development;Diagnosis;Diagnostic;Diagnostic tests;Disease;disorder prevention;Enrollment;Ensure;Epidemiology;Etiology;experience;Goals;Guidelines;Hospitalization;Hospitalized Child;Hospitals;implementation science;improved;Incidence;Individual;Institution;Interdisciplinary Study;Intervention;Knowledge;Laboratories;Leadership;Logistic Regressions;Medicine;Mentors;Modeling;Molecular;Molecular Diagnostic Techniques;Mortality Vital Statistics;multidisciplinary;Outcome;pathogen;Patients;Performance;Pneumonia;point of care;Population;population based;predictive modeling;prognostic;programs;prospective;Research;Research Infrastructure;Research Personnel;Research Priority;research study;Research Training;Risk;Risk Estimate;Ruta;Severities;Severity of illness;Site;skills;Specific qualifier value;Stratification;surveillance study;Technology;Tennessee;Time;tool;Training;United States;Universities;Utah;Validation;validation studies;Variant;Work,Development and Validation of a Clinical Prediction Rule for Pediatric Pneumonia,104779,MID,Microbiology and Infectious Diseases Research Committee,,,2,172098,
8606754,K23,HD,5,N,02/04/2014,02/01/2014,01/31/2015,865,K23HD055100,,PA-09-043,5K23HD055100-05,NICHD:132300\,Other Research Related,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,BOSTON,UNITED STATES,,07,076593722,US,CHILDREN'S HOSPITAL CORPORATION,MA,021155737," PUBLIC HEALTH RELEVANCE STATEMENT The development of metabolic abnormalities associated with combination antiretroviral therapy (cART) will have a profound impact on HIV-infected patients worldwide. Although the number of children with perinatally- acquired HIV has diminished in the United States, there remain millions of HIV-infected children worldwide who need cART to treat their HIV disease and survive without progression to AIDS. However, the potential increase in cardiovascular morbidity and diabetic complications associated with cART will affect long-term survival of HIV-infected children, and will increase the burden on healthcare systems everywhere. Children with perinatally-acquired HIV infection will likely require cART for life and represent a unique, disadvantaged population of patients who may develop mitochondrial dysfunction and metabolic complications at a very early age. Given that cART is so critical to the care of HIV-infected children, it is imperative that we understand the mechanisms of these potential toxicities associated with antiretroviral medications. We can then find ways to reduce these effects by devising interventions aimed at preventing or stopping the progression of metabolic disease.",8544789;,"SHARMA, TANVI SHAH;","RUSSO, DENISE ",02/01/2010,01/31/2015,Acquired Immunodeficiency Syndrome;Address;Adolescence;Adolescent;Adult;Adverse effects;Affect;Age;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;Biological Assay;Birth;Blood;Body Composition;Body fat;Boston;Carbohydrates;Cardiovascular Diseases;Cardiovascular system;Caring;catalyst;Center for Translational Science Activities;Characteristics;Child;Childhood;Cholesterol;Chronic Disease;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;cohort;Cohort Studies;Collaborations;Communicable Diseases;Complications of Diabetes Mellitus;Databases;demographics;design;Development;DEXA;Diabetes Mellitus;Diet;Dietary intake;Disadvantaged;Disease;Disease Progression;DNA biosynthesis;Enrollment;Environment;enzyme activity;Evaluation;Exhibits;experience;Exposure to;Face;Faculty;Family;Fatty acid glycerol esters;Fostering;Funding;Future;Genetic Transcription;Glucose;Goals;Grant;Growth;Healthcare Systems;HIV;Hyperlipidemia;Hypertriglyceridemia;Impairment;in utero;Individual;Infant;Insulin;Insulin Resistance;insulin sensitivity;Intake;Intervention;Laboratories;Laboratory Study;Learning;Life;Link;Lipids;Lipodystrophy;longitudinal analysis;longitudinal database;Measures;Mentors;Metabolic;Metabolic Diseases;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Proteins;Morbidity - disease rate;Morphology;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;nucleoside analog;nutrition;Nutritional;Obesity;Oxidative Phosphorylation;Oxidative Stress;Participant;patient population;Patients;Pediatric Hospitals;pediatric human immunodeficiency virus;Perinatal;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Plasma;Play;Population;premature;Prevalence;prevent;Prevention;programs;Protease Inhibitor;Proteins;protocol development;public health medicine (field);public health relevance;Public Health Schools;Recording of previous events;Regimen;Research;Research Methodology;Research Personnel;research study;Risk;Risk Factors;Role;Scanning;Serum;success;Swab;Techniques;Time;Toxic effect;Training;Training Programs;translational study;treatment center;treatment duration;United States;United States National Institutes of Health;Universities;Viral Load result;Virus;Virus Diseases;Work;young adult;Zidovudine,The Role of Mitochondrial Toxicity in Metabolic Complications of Pediatric HIV,55100,ACE,AIDS Clinical Studies and Epidemiology Study Section,,,5,132300,
8609047,K23,HD,5,N,02/06/2014,02/01/2014,01/31/2015,865,K23HD067224,SCHOOLS OF MEDICINE,PA-10-060,5K23HD067224-04,NICHD:130366\,Other Research Related,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,SALT LAKE CITY,UNITED STATES,OBSTETRICS &GYNECOLOGY,02,009095365,US,UNIVERSITY OF UTAH,UT,84112," 8. Project Narrative/Relevance: This proposal will contribute to increased understanding of SPTB therapies by identifying the subset of women most likely to respond to 17OHPC and indomethacin, which will allow us to work towards individualizing treatment, maximizing benefit and limiting side effects. This has the potential to lead to key intervention trials among other groups of pregnant women. These advances may result in individualized preterm birth interventions, which in turn could lower the overall rate of both primary and recurrent SPTB and its corresponding neonatal morbidity and mortality.",9833045;,"MANUCK, TRACY ANN;","ZAJICEK, ANNE ",02/01/2011,01/31/2016,7q21;7q22;Accounting;Acute;Address;Admixture;Adverse effects;African American;Anti-inflammatory;Anti-Inflammatory Agents;Area;Authorization documentation;Award;base;Camping;Candidate Disease Gene;career;career development;Cervical;Chromosomes;Clinical;Clinical Trials;cohort;Collaborations;cost effective;CYP3A4 gene;cytochrome P450 3A;cytokine;Data;data acquisition;design;Development Plans;DNA;Enzymes;Ethics;experience;Fellowship;fetal;Funding;gene environment interaction;Genes;Genetic;genetic analysis;genetic epidemiology;Genetic Polymorphism;Genetic Research;Genomics;Genotype;Goals;Haplotypes;High Risk Woman;Human;Hydroxyprogesterone Caproate;Indomethacin;Infant;Inflammation;Inflammatory;Institution;Intervention;Intervention Trial;K-Series Research Career Programs;Lead;Leadership;legal implication;Logistic Regressions;Maps;meetings;Mentors;Metabolic;Metabolism;Methods;National Institute of Child Health and Human Development;neonatal morbidity;Neonatal Mortality;Outcome;Pathway interactions;patient oriented;Patients;Perinatal;Pharmaceutical Preparations;Pharmacogenomics;Pharmacology;Physicians;Placebos;Populations at Risk;Pregnancy Outcome;Pregnant Women;premature;Premature Birth;prevent;Prevention;Process;Progesterone;Progesterone Receptors;programs;Prolonged Pregnancy;Prophylactic treatment;Prostaglandins;Proteomics;public health relevance;Recruitment Activity;Recurrence;Research;Research Design;Research Training;response;Role;Sampling;Scientist;Silver;Single Nucleotide Polymorphism;Site;skills;skills training;Swab;Testing;Therapeutic Intervention;Time;Tocolysis;Tocolytic Agents;Training;Universities;Utah;Vagina;Variant;Variation (Genetics);ward;Woman;Work,Pharmacogenomics of Preterm Birth Prevention and Treatment,67224,ZHD1,Special Emphasis Panel,,,4,130366,
8609048,K23,HD,5,N,02/04/2014,02/01/2014,01/31/2015,865,K23HD068394,,PA-10-060,5K23HD068394-03,NICHD:124906\,Other Research Related,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,WASHINGTON,UNITED STATES,,00,143983562,US,CHILDREN'S RESEARCH INSTITUTE,DC,20010, Parental refusal of childhood vaccines on behalf of their children is an increasingly common public health problem which has lead to disease outbreaks. African Americans have lower childhood vaccination rates and greater mistrust of the medical establishment than other racial/ethnic groups. Understanding how personal support networks and normative values among African-American parents are associated with vaccine decision- making may help us develop more effective peer outreach interventions to increase vaccine acceptance among African-American parents and reduce the incidence of vaccine-preventable diseases.         ,9187384;,"FU, LINDA Y;","HAVERKOS, LYNNE ",02/01/2012,01/31/2017,Adolescent;African American;Age;American;Awareness;base;behavior influence;Benefits and Risks;Cervical;Characteristics;Child;Childhood;Church;Communication;Communities;Complementary and alternative medicine;Cross-Sectional Studies;Daughter;Death Rate;Decision Making;density;design;Disease;Disease Outbreaks;Emotional;Ethics;Ethnic group;Exposure to;Family;Feedback;Friends;Gender;girls;Goals;Health;Health behavior;Human Papilloma Virus Vaccine;Human Papillomavirus;Immunization;Incidence;innovation;Intervention;Investigation;Lead;Licensure;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;Morals;Mothers;outreach;Parents;Participant;peer;peer influence;Persons;Physicians;Population;public health medicine (field);Race;racial and ethnic;Recommendation;Reporting;Risk;Sexually Transmitted Diseases;Social Network;social norm;Source;Structure;Surveys;Teenagers;Text;Trust;United States;United States Dept. of Health and Human Services;Vaccination;Vaccines;Voice;Woman;Work,Social Network Influences on Values Related to Parental HPV Vaccine Refusal,68394,CHHD,Developmental Biology Subcommittee,,,3,124906,
8606486,K23,HD,5,N,02/04/2014,02/01/2014,01/31/2015,865,K23HD070913,SCHOOLS OF MEDICINE,PA-10-060,5K23HD070913-03,NICHD:133920\,Other Research Related,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,ANN ARBOR,UNITED STATES,EMERGENCY MEDICINE,12,073133571,US,UNIVERSITY OF MICHIGAN,MI,481091274," Preventable injuries sustained by child occupants in motor vehicle collisions are a significant and costly public health concern. Child passenger restraint systems have proven effective in reducing the risk of injury and death associated with a motor vehicle collision, yet there are few evidence-based approaches to promote the correct and consistent use of the size-appropriate child passenger restraint. By using successful strategies for behavior change, including motivational interviewing and personalized health communication, the proposed intervention could remarkably improve passenger safety among children who contact the health system through the emergency department.            ",10323934;,"MACY, MICHELLE LEA;","HAVERKOS, LYNNE ",02/20/2012,01/31/2017,12 year old;3 year old;7 year old;Accident and Emergency department;Adolescent;Adult;Age;Attitude;Awareness;base;Behavior;behavior change;Behavior Therapy;brief intervention;Car Seats;career development;Caring;Cause of Death;Cessation of life;Child;Childhood;Childhood Injury;Clinical;communication behavior;Counseling;Data;design;Development;Development Plans;disability;Educational aspects;Emergency Care;Engineering;Ensure;evidence base;experience;Faculty;Family;Focus Groups;Funding;Generic Drugs;Health behavior;Health Communication;Health Services Research;Health system;Heart Diseases;Hispanics;Hospitals;improved;Infant;Influenza;Injury;injury prevention;interest;Intervention;K-Series Research Career Programs;Knowledge;Laws;Lead;Legal;Life;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Minority;motivated behavior;Motivation;motivational enhancement therapy;multidisciplinary;novel strategies;Pamphlets;Parents;patient oriented;Patients;Pattern;Phase;pilot trial;Pneumonia;Positioning Attribute;primary care setting;Printing;programs;Provider;public health medicine (field);Punishment;Qualifying;Qualitative Methods;Randomized;Randomized Controlled Trials;Regulation;Research;research and development;Research Personnel;Research Training;response;restraint;Risk;Role;Safety;Seat Belts;Self Determination;Sepsis;skills;Statutes and Laws;Subgroup;Surveys;System;Techniques;Testing;theories;therapy development;Training;Vehicle crash;Visit,A Brief Intervention to Increase Size-Appropriate Child Passenger Restraint Use,70913,CHHD,Developmental Biology Subcommittee,,,3,133920,
8619571,K99,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,K99AA021264,SCHOOLS OF MEDICINE,PA-11-197,5K99AA021264-02,NIAAA:79606\,Other Research Related,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,MIAMI,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,21,071298814,US,FLORIDA INTERNATIONAL UNIVERSITY,FL,33199,"Approximately 18 million Americans suffer from alcohol use disorders (AUDs), and one of the least appreciated medical complications of alcohol abuse is its effect on the immune system. To date, there is a growing demand for more effective treatments for AUDs, and research to elucidate the molecular mechanisms of the effects of alcohol on immune modulation;therefore, this application herein will study the effects of alcohol and the role of epigenetic mechanisms such as histone deacetylation on the modulation of cannabinoid genes (CBRs) in human immune cells. A long term benefit of elucidating the molecular mechanisms associated with the interaction of alcohol with HDACs and CBRs will be the application of what is learned in this study to aid in the development of novel therapeutics for th prevention of AUDs.",10367924;,"AGUDELO, MARISELA;","JUNG, KATHY ",02/15/2013,01/31/2015,"Acute;addiction;Agonist;Alcohol abuse;alcohol abuse therapy;Alcohol dependence;alcohol effect;alcohol exposure;alcohol use disorder;Alcohol-Related Disorders;Alcohols;Alzheimer's Disease;American;Animal Model;Anti-inflammatory;Anti-Inflammatory Agents;Antioxidants;Area;Award;base;cannabinoid receptor;Cannabinoids;career development;Cell Line;Cells;Cessation of life;chromatin remodeling;Chronic;Cocaine;Communicable Diseases;Complex;Data;Dendritic Cells;Development;Development Plans;Disease;Drug Addiction;effective therapy;Ensure;Epigenetic Process;experience;Figs - dietary;Generations;Genes;Genetic;Goals;HDAC2 gene;high risk;Histone Acetylation;Histone Deacetylase Inhibitor;Histone Deacetylation;Histones;Human;human CCR10 protein;human GPRC5C protein;Immune;Immune system;Immune System Diseases;immunoregulation;improved;in vivo;Individual;Inflammation;Inflammatory;inhibitor/antagonist;innovation;interest;interleukin-12 subunit p40;Investigation;Knowledge;Laboratory Research;Learning;Leukocytes;macrophage;Mediating;Medical;medical complication;meetings;Mentors;Mentorship;Mission;Molecular;monocyte;National Institute on Alcohol Abuse and Alcoholism;Natural immunosuppression;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;novel;novel therapeutics;Opioid Receptor;Oxidative Stress;Oxidative Stress Induction;Pharmaceutical Preparations;Phase;Physiological;Play;prevent;Prevention;Process;Production;receptor;Receptor Gene;Receptor, Cannabinoid, CB1;Reporting;Research;Research Personnel;Role;Self Administration;skills;Solid;System;Testing;Therapeutic;therapeutic target;TNF gene;Trichostatin A;United States;Up-Regulation (Physiology);Work",EtOH-induced Immunomodulation: Role of Histone Deacetylases and Cannabinoid Genes,21264,AA,Biomedical Research Review Subcommittee,,,2,79606,
8613504,K99,HL,5,N,02/02/2014,02/01/2014,01/31/2015,837,K99HL116778,SCHOOLS OF MEDICINE,PA-11-197,5K99HL116778-02,NHLBI:129060\,Other Research Related,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,BIOCHEMISTRY,07,188435911,US,UNIVERSITY OF MARYLAND BALTIMORE,MD,212011508,"Narrative  Systematic beating of the heart requires the rapid transmission of mechanical and electrical activity of individual heart cells through specialized cell-[unreadable]cell junctions. Disruption in the components of these junctions interrupts regular heart function and leads to heart disease. The goal of this proposal is to characterize a newly identified component of this junction, obscurin&#8208;D, in health and disease.",7875227;,"ACKERMANN, MAEGEN ALLYSUM;","CARLSON, DREW E",02/05/2013,01/31/2015,Acute;Address;Affinity;Animals;Ankyrins;Architecture;base;Binding (Molecular Function);Binding Sites;Biochemical;Biological Assay;Biology;Cardiac;Cardiac Myocytes;career development;cell motility;Cells;Cellular Membrane;Collaborations;Complex;Coupling;Custom;Cytoskeletal Proteins;Cytoskeleton;Data;design and construction;Development;Development Plans;Disease;Disease model;Dot Immunoblotting;Echocardiography;Elements;Ensure;Equipment;Event;experience;Family;Figs - dietary;Fluorescence Microscopy;Functional disorder;Gene Delivery;Genes;genetic manipulation;Goals;Grant;Growth;Health;Heart;heart cell;Heart Diseases;Heart failure;heart function;Immunologic Techniques;In Vitro;in vivo;Individual;Injection of therapeutic agent;innovation;Intercalated disc;Intercellular Junctions;Laboratories;Lead;Length;Ligands;Lipids;Location;Maintenance;Mass Spectrum Analysis;Mechanics;Mediating;member;Membrane;Membrane Microdomains;Mentors;Methodology;Molecular;Molecular Biology Techniques;mouse model;Mus;Muscle;Muscle Cells;mutant;Mutation;Myocardial Infarction;Normalcy;novel;obscurin;overexpression;Pathology;Performance;Pericardial body location;PH Domain;Phase;Phosphorylation;Phosphotransferases;Physiological;Physiology;Play;Positioning Attribute;postnatal;pressure;Protein Family;Protein Isoforms;Proteins;Proteome;Proteomics;Reagent;Regulatory Pathway;Relative (related person);Research;research and development;Research Personnel;research study;Resources;rho guanine nucleotide exchange factor p115;RNA Splicing;Role;Sarcolemma;Sarcomeres;Sarcoplasmic Reticulum;Signal Transduction;Striated Muscles;Subcellular structure;Surface Plasmon Resonance;Techniques;Testing;Time;Tissues;Training;Training Support;translational approach;Translations;transmission process;two-dimensional;United States National Institutes of Health;Viral;Work,Novel Locations;Familiar Functions: Obscurin at the Cardiac Intercalated Disc,116778,ZHL1,Special Emphasis Panel,,,2,129060,
8616404,K99,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,K99MH099405,SCHOOLS OF MEDICINE,PA-11-197,5K99MH099405-02,NIMH:90000\,Other Research Related,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,PROVIDENCE,UNITED STATES,NEUROSCIENCES,01,001785542,US,BROWN UNIVERSITY,RI,02912,PUBLIC HEALTH RELEVANCE: Anxiety disorders are very prevalent conditions and effective treatments are scarce. Thus looking for alternatives to current pharmacological methods is a priority for researchers in the field. This project proposes to study the CaV2.2 channel as a novel target for drugs with marked anxiolytic effects.                ,10312665;,"ANDRADE, ARTURO;","DESMOND, NANCY L",02/08/2013,01/31/2015,Affect;Agonist;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;Area;Bathing;Behavior;Behavioral;Biological;Brain;Collaborations;Conotoxin;Coupling;Data;dentate gyrus;Dependency (Psychology);Drug Targeting;effective therapy;Electrophysiology (science);Excitatory Postsynaptic Potentials;Excitatory Synapse;Exhibits;Exons;feeding;Functional disorder;G Protein-Coupled Receptor Genes;gamma-Aminobutyric Acid;Genes;Glutamates;Hippocampus (Brain);Inhibitory Synapse;Interneurons;Knockout Mice;Link;Measures;Medial;Mediating;Methods;Molecular;Molecular Biology;Monitor;mouse model;Mus;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;novel;Opioid;Perforant Pathway;Pharmaceutical Preparations;Phase;Physiologic pulse;postsynaptic;presynaptic;Probability;programs;Protein Inhibition;Proteins;public health relevance;receptor coupling;Relative (related person);Reporting;Research;Research Personnel;RNA Splicing;Role;skills;Slice;Synapses;Testing;Time;transmission process;voltage-dependent calcium channel (P-Q type),Role of Gi/o-Protein Inhibition of CaV2.2 Channels in Anxiety Behavior,99405,ZMH1,Special Emphasis Panel,,,2,90000,
8616034,P01,CA,5,N,02/03/2014,02/01/2014,01/31/2015,396,P01CA082834,SCHOOLS OF MEDICINE,PAR-09-025,5P01CA082834-15,NCI:1050451\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,BURLINGTON,UNITED STATES,BIOCHEMISTRY,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405,RELEVANCE: The program will link molecular mechanisms by which nuclear structure ensures fidelity of biological control and deregulation of parameters of nuclear architecture to disease progression in cancer. We will define novel components of nuclear organization that can be targeted for innovative cancer therapies.,1864839 (contact);1944364;,"STEIN, GARY S. (contact);STEIN, JANET L;","KNOWLTON, JOHN R.",02/01/2002,01/31/2016,Address;Aneuploidy;Architecture;attenuation;Biochemical;Biological;Bone Diseases;Breast Cancer Cell;breast tumorigenesis;cancer cell;Cancer Control;cancer gene expression;cancer therapy;Cell Fate Control;cell growth;Cell Nucleus;cell transformation;Cells;Cellular Morphology;Chromatin;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Chromosome Segregation;Chromosome Structures;Complex;Development;Dimensions;Disease Progression;Ensure;Environment;Epigenetic Process;Epithelial Cells;Gene Expression;Gene Expression Regulation;Gene Structure;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genomics;Growth;Histones;in vivo;inhibitor/antagonist;innovation;Innovative Therapy;insight;interdisciplinary approach;Investigation;leukemia;leukemogenesis;Link;link protein;malignant breast neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Mediating;MicroRNAs;Microscopic;Microscopy;Mitosis;Mitotic;Molecular;Morphology;multidisciplinary;neoplastic cell;Normal Cell;novel;Nuclear;Nuclear Structure;Osteolysis;programs;Property;Proteins;Proteomics;Regulation;Regulator Genes;Regulatory Pathway;Research Personnel;Resource Sharing;Signal Transduction;Supporting Cell;Tissue Differentiation;transcription factor;Transcriptional Regulation;tumor;Tumor Biology;tumorigenesis;Work,Nuclear Structure and Gene Expression,82834,ZCA1,Special Emphasis Panel,,,15,1050451,
8444558,P01,CA,5,N,02/03/2014,02/01/2014,01/31/2015,,P01CA082834,,PAR-09-025,5P01CA082834-15,NCI:242416\,Research Projects,2013,NATIONAL CANCER INSTITUTE,,,,,,,,UNIV OF VERMONT STATE AGR COLL,,,RELEVANCE (See instructions):  Changes in the overall shape and structure ofthe nucleus are pathological hallmarks of cancer cells that are linked to cellular transformation. This study will use state-of-the-art methods to characterize how targeting of oncogenic transcription factors to specific subnuclear structures and mitotic chromosomes supports gene regulation as components of a novel epigenetic mechanism ('architectural epigenetics').,1864839;,"STEIN, GARY S.;",,,,"Acetylation;Architecture;Biochemical;Biological;Breast Cancer Cell;cancer cell;Cancer stem cell;Cell division;Cell Fate Control;cell growth;Cell Nucleus;Cells;Chimeric Proteins;Chromatin;Chromatin Structure;Chromosomes;Chromosomes, Human, Pair 1;Collaborations;Commit;Dimensions;DNA Methylation;DNA Polymerase I;DNA Polymerase II;DNA Sequence;Environment;Epigenetic Process;Etiology;Event;Exhibits;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genomics;Growth;Histones;Instruction;Interphase;leukemia;Leukemia, Myelocytic, Acute;Link;Malignant Neoplasms;Mediating;metaplastic cell transformation;Methods;Microscopic;Microscopy;Mitosis;Mitotic;Mitotic Chromosome;Modification;Molecular;Normal Cell;novel;Nuclear;Nuclear Structure;Oncogenic;Phenotype;Post-Translational Protein Processing;programs;Promotor (Genetics);Proteins;Proteomics;Regulation;Regulator Genes;Research Personnel;Role;Shapes;Signal Transduction;Somatic Cell;Structure;t(8;21)(q22;q22);trafficking;transcription factor;tumorigenesis",Subnuclear Targeting and Architectural Epigenetics in Cancer Cells,82834,ZCA1,Special Emphasis Panel,8765,,15,,242416
8444559,P01,CA,5,N,02/03/2014,02/01/2014,01/31/2015,,P01CA082834,,PAR-09-025,5P01CA082834-15,NCI:233211\,Research Projects,2013,NATIONAL CANCER INSTITUTE,,,,,,,,UNIV OF VERMONT STATE AGR COLL,,,,1901649;,"IMBALZANO, ANTHONY N;",,,,Address;Affect;Architecture;ATP phosphohydrolase;base;Basement membrane;Biological Models;bone;Breast;Breast Cancer Cell;cancer cell;Cell Cycle Progression;Cell Differentiation process;cell growth;Cell Nucleus;cell transformation;Cells;Cellular Morphology;Chromatin;chromatin remodeling;Chromatin Structure;Collaborations;Development;Diagnosis;Enzymes;Epithelial Cell Proliferation;Epithelial Cells;Extracellular Matrix;Funding;Gene Expression;genetic regulatory protein;Genetic Transcription;Genomics;Higher Order Chromatin Structure;Individual;Instruction;Lead;Malignant - descriptor;malignant breast neoplasm;Malignant Neoplasms;malignant phenotype;Mammary gland;Mammary Gland Parenchyma;Mammary Neoplasms;metaplastic cell transformation;Metastatic Neoplasm to the Bone;Molecular;monolayer;Morphology;Mus;Neoplasm Metastasis;neoplastic cell;Nuclear;Nuclear Lamina;Nuclear Structure;Oncogenes;overexpression;Phenotype;Physiological;programs;Property;reconstitution;Regulation;Research Personnel;Role;Shapes;SMARCA4 gene;Staging;Structural Protein;Structure;Testing;Tissues;tumor;Tumor Cell Line;tumor progression;Tumor Suppressor Proteins;tumorigenesis,Regulatory Mechanisms Controlling Breast Tissue Development and Transformation,82834,ZCA1,Special Emphasis Panel,8766,,15,,233211
8444560,P01,CA,5,N,02/03/2014,02/01/2014,01/31/2015,,P01CA082834,,PAR-09-025,5P01CA082834-15,NCI:184681\,Research Projects,2013,NATIONAL CANCER INSTITUTE,,,,,,,,UNIV OF VERMONT STATE AGR COLL,,,,1867212;,"LIAN, JANE B;",,,,Biochemical;Biological;bone;Bone Diseases;Bone Matrix;Breast;Breast Cancer Cell;cancer cell;Cancer Patient;Cell Nucleus;Cells;Cities;Code;cohort;Collaborations;Complementary DNA;Complex;Country;County;Coupled;deep sequencing;Disease;Disease Progression;Distal;Epithelial Cells;Erinaceidae;Event;Fatty acid glycerol esters;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic regulatory protein;Human;In Situ;In Vitro;insight;Integrins;inter-alpha-inhibitor;Lead;Location;malignant breast neoplasm;Malignant neoplasm of prostate;Mammary gland;Mammary Neoplasms;Massachusetts;MCF7 cell;Mediating;Mediator of activation protein;medical schools;Metalloproteases;Metastatic Neoplasm to the Bone;Molecular;Molecular Profiling;Mouse Mammary Tumor Virus;mouse model;mutant;Mutation;Names;Neoplasm Metastasis;neoplastic cell;Non-Malignant;Normal Cell;novel;Nuclear;Nuclear Matrix;Nuclear Matrix-Associated Proteins;Nuclear Structure;Oncogenic;Osteogenesis;Osteolytic;Outcome;parathyroid hormone-related protein;Patients;Performance;Polyomavirus;prevent;Property;Prostatic Neoplasms;Proteins;Proteomics;Province;response;Runx2 protein;Sampling;Scaffolding Protein;Severity of illness;Signal Pathway;Signal Transduction;Site;Staging;Supporting Cell;Transcription Coactivator;transcription factor;tumor;tumor growth;tumor microenvironment;Universities;validation studies;Vascular Endothelial Growth Factors;Viral Tumor Antigens;Work,Runx2 Organizes Transcriptional Complexes in Nuclear Microenvironments to Support,82834,ZCA1,Special Emphasis Panel,8767,,15,,184681
8444561,P01,CA,5,N,02/03/2014,02/01/2014,01/31/2015,,P01CA082834,,PAR-09-025,5P01CA082834-15,NCI:230127\,Research Projects,2013,NATIONAL CANCER INSTITUTE,,,,,,,,UNIV OF VERMONT STATE AGR COLL,,,"RELEVANCE (See instructions): Imaging technologies, and especially microscopy, are in a period of explosive growth in sophistication, resolution, and power. Increasing, advanced microscopy techniques are essential tools for understanding the changes in cell and tissue organization which are central to our emerging understanding of cancer.",1858695;,"NICKERSON, JEFFREY A;",,,,Antibodies;Binding (Molecular Function);Biochemical;Cells;Complex;Computer software;Computers;Confocal Microscopy;Coupled;digital;Dimensions;Electron Microscopy;Electrons;Equipment;fluorescence microscope;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Gene Expression;Gold Colloid;Growth;Image;Image Analysis;image processing;Imaging technology;Instruction;Kinetics;Life;macromolecular assembly;Malignant Neoplasms;Measures;Microscopic;Microscopy;Nuclear Structure;Nucleic Acids;Preparation;Process;Proteins;research study;Resolution;Sampling;Scanning Transmission Electron Microscopy Procedures;Services;Techniques;Time;Tissues;tool;Training,Microscopy,82834,ZCA1,Special Emphasis Panel,8768,,15,,230127
8444562,P01,CA,5,N,02/03/2014,02/01/2014,01/31/2015,,P01CA082834,,PAR-09-025,5P01CA082834-15,NCI:160016\,Research Projects,2013,NATIONAL CANCER INSTITUTE,,,,,,,,UNIV OF VERMONT STATE AGR COLL,,,RELEVANCE (See instructions):  The Administrative Core will perform program management and administration functions to insure smooth operation and integration ofthe program at all levels.,1864839;,"STEIN, GARY S.;",,,,Advisory Committees;animal care;Animal Model;Animals;Biological;Budgets;Cancer Control;Code;Committee Members;cost;Documentation;Ensure;Evaluation;Expenditure;follow-up;Gene Expression;Guidelines;Health;Health Benefit;Health Insurance;Healthcare;Housing;Human Resources;human subject;In-Migration;Instruction;Insurance Benefits;International;Leadership;Logistic Models;Manuscripts;Massachusetts;meetings;Microscopy;Monitor;Nuclear Structure;Occupational activity of managing finances;operation;payment;Personnel Management;Photocopying;Postdoctoral Fellow;Preparation;Principal Investigator;Process;programs;Progress Reports;Protocols documentation;Radiation;Regulation;Report (document);Reporting;Research Personnel;Research Project Grants;Safety;Schedule;Scientist;Secure;Services;sharing data;Students;Time;Travel;United States National Institutes of Health;Universities;Visit,ADMINISTRATIVE,82834,ZCA1,Special Emphasis Panel,8770,,15,,160016
8611945,P01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,837,P01HL059408,SCHOOLS OF MEDICINE,,5P01HL059408-15,NHLBI:1825052\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,PHYSIOLOGY,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405,"Pumping of the heart Is generated by Interactions between thin and thick, contractile protein filaments within  cardiac muscle. Cardiac myosin-binding protein-C (cMyBP-C) is a thick filament component that modulates  cardiac contraction. Genetic defects in cMyBP-C result in heart failure and sudden death.:: Gaps in our  understanding of cMyBP-C functionality still remain. This PPG will define cMyBP-C's molecular structure  function, and regulation focusing on cMyBP-C as a target for therapeutic intervention.",1884066;,"WARSHAW, DAVID M;","WANG, LAN-HSIANG ",02/01/2000,01/31/2015,"3-Dimensional;Accounting;Actins;Activities of Daily Living;Actomyosin;Address;adrenergic;Adrenergic Agents;Affect;American;Animals;Arrhythmia;Arts;Attention;base;Behavior;Belief;Binding (Molecular Function);Biological Assay;Biology;Biophysics;C2 Domain;Cardiac;Cardiac Myosins;Cardiomyopathies;Cardiomyopathy, Hypertrophic, Familial;Cardiovascular Diseases;Cardiovascular system;Cause of Death;cell motility;Cessation of life;Characteristics;citrate carrier;Clinical;clinical phenotype;Collaborations;connectin;Consensus;Contractile Proteins;Cytoskeletal Proteins;Data;Death, Sudden, Cardiac;Defect;Diagnosis;Dilated Cardiomyopathy;Disease;Electron Microscopy;Electrons;Etiology;Event;Fiber;Filament;Foundations;Future;Gene Mutation;Generations;Genetic;Goals;Grant;Head;Head and neck structure;Health;Health Care Costs;Heart;heart cell;Heart Diseases;Heart failure;Heart Hypertrophy;Human;Hypertrophic Cardiomyopathy;Hypertrophy;improved;In Vitro;Individual;Inherited;insight;Institution;interest;Investigation;Laboratories;Lasers;Lead;Left;Link;Location;Massachusetts;Measurement;Mechanics;medical schools;Medicine;Microfilaments;Microscopic;Mission;Modeling;Molecular;Molecular Biology;molecular mechanics;Molecular Motors;Molecular Structure;Motor;mouse model;multidisciplinary;Mus;Muscle;Muscle Cells;Muscle Fibers;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Myocardium;Myofibrils;Myosin ATPase;Myosin Heavy Chains;myosin-binding protein C;National Heart, Lung, and Blood Institute;Organ;Outcome;Patients;Performance;Phosphorylation;Physiological;Physiology;Play;Point Mutation;Population;Post-Translational Protein Processing;premature;Preparation;Prevention;Production;Productivity;programs;Protein Binding;Proteins;Pump;reconstruction;Regulation;Research;research facility;Research Personnel;Resolution;Role;Sarcomeres;Scientist;single molecule;Site-Directed Mutagenesis;Skin;spatial relationship;Structural Biologist;structural biology;Structure;Structure-Activity Relationship;Sudden Death;Techniques;Therapeutic Intervention;therapeutic target;Thick;Thick Filament;Thin Filament;Time;Transgenic Mice;United States;Universities;Ventricular;Vermont","Cardiac Myosin Binding Protein-C:  Structure, Function, and Regulation",59408,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,,15,1825052,
8611946,P01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,,P01HL059408,,,5P01HL059408-15,NHLBI:421748\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405,"Pumping of the heart is generated by interactions between the thin and thick protein filaments that make up cardiac muscle. Myosin-binding protein C (MyBP-C) is a thick filament component that regulates cardiac contraction in response to stimulation, and defects in MyBP-C are a cause of cardiac disease. In this project we will use electron microscopy to reveal the molecular organization of MyBP-C in cardiac muscle, providing insights into the structural mechanisms by which it functions in the normal beating heart.",1879061;,"CRAIG, ROGER W;",,,,"Actins;Actomyosin;Address;adrenergic;Adrenergic Agents;Antibodies;base;Binding (Molecular Function);Biophysics;C-terminal;Cardiac;Cardiac Myosins;Cardiomyopathy, Hypertrophic, Familial;citrate carrier;Cryoelectron Microscopy;Data;Defect;Electron Microscopy;F-Actin;Filament;flexibility;Foundations;Goals;Head;Heart;Heart Diseases;Hypertrophic Cardiomyopathy;Image;image processing;In Vitro;in vivo;Individual;Inherited;insight;Knowledge;Label;Microfilaments;Modeling;Molecular;Molecular Conformation;Muscle;mutant;Mutation;Myocardium;Myosin ATPase;myosin-binding protein C;N-terminal;Negative Staining;particle;Phosphorylation;Physiological;Play;Positioning Attribute;Protein Isoforms;Proteins;Pump;Regulation;research study;Resolution;response;Role;Running;Sarcomeres;Sectioning technique;single molecule;Site;Skeletal muscle structure;Solid;Structural Models;Structure;Surface;Techniques;Testing;Thick;Thick Filament;Thin Filament;Transgenic Organisms;Tropomyosin;Vertebral column",cMyBP-C and Native Thick Filament Structure,59408,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7774,,15,,421748
8611947,P01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,,P01HL059408,,,5P01HL059408-15,NHLBI:350615\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405,"cMyBP-C is critical to normal cardiac performance. Using single molecule biophysical techniques to characterize the molecular mechanism of cMyBP-C function, the results may provide the potential for novel therapies in cases of heart failure associated with genetic mutations in cMyBP-C.",1884066;,"WARSHAW, DAVID M;",,,,"Actins;Activities of Daily Living;Actomyosin;adrenergic;Adrenergic Agents;Affect;Affinity;Alanine;Animals;Aspartic Acid;base;Binding (Molecular Function);Biological Assay;Biomechanics;Cardiac;Cardiac Myosins;Cardiomyopathy, Hypertrophic, Familial;cell motility;Clinical;Complement;Cyclic AMP-Dependent Protein Kinases;Data;design;Equilibrium;Fiber;Gene Mutation;Generations;Head;Heart;Heart failure;In Vitro;Intervention;Kinetics;Knockout Mice;Label;Lasers;Length;Literature;Location;Mechanics;Molecular;molecular mechanics;Molecular Structure;Motion;Motor;mouse model;Mus;mutant;Mutation;Myocardium;Myosin ATPase;Myosin Subfragments;myosin-binding protein C;N-terminal;novel;novel therapeutics;Pattern;Performance;Phosphorylation;Phosphorylation Site;Physiological;Population;Positioning Attribute;programs;Property;Regulation;Relative (related person);research study;Serine;single molecule;Site;stoichiometry;Structure;System;Techniques;Thick;Thick Filament;Thin Filament;Transgenic Mice",cMyBP-C: Molecular Mechanisms of Actomyosin Modulation,59408,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7775,,15,,350615
8611948,P01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,,P01HL059408,,,5P01HL059408-15,NHLBI:222124\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405,The heart contains a protein called myosin binding protein C that is critical to its normal function. This protein is modified during the development of heart disease and we will model these changes in the mouse using genetic engineering techniques. By making these changes and seeing the consequences we can determine their usefulness in developing novel therapeutics for the treatment of heart disease.,1882725;,"ROBBINS, JEFFREY;",,,,"Actins;Actomyosin;Affect;Alanine;Animals;Aspartate;Binding (Molecular Function);Binding Sites;Biochemical Genetics;Calmodulin;Cardiac;Cardiac Myocytes;Cardiac Myosins;Cardiomyopathy, Hypertrophic, Familial;Charge;Collaborations;Cyclic AMP-Dependent Protein Kinases;Data;Development;Dissection;Failure (biologic function);Fiber;Gene Mutation;Generations;Genetic Engineering;Heart;Heart Diseases;Heart failure;Human;human data;Hypertrophy;In Vitro;in vivo;Individual;Injury;Ischemia;Kinetics;Mechanics;Mediating;mimetics;Modeling;Molecular;Molecular Motors;Motion;Mus;Mutate;Mutation;Myosin ATPase;myosin-binding protein C;novel therapeutics;Organ;Outcome;Pathologic;Pattern;Performance;Phenotype;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Population;Post-Translational Protein Processing;Preparation;Protein Isoforms;Protein Kinase C;Proteins;Regulation;response;Role;Sarcomeres;Serine;Site;skeletal;Stress;Structure;Structure-Activity Relationship;Techniques;Testing;therapeutic target;Thick Filament;Thin Filament;Tissues;Transgenic Mice;Transgenic Organisms",cMyBP-C: Phosphorylation-Dependent Regulation In Vivo,59408,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7776,,15,,222124
8611949,P01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,,P01HL059408,,,5P01HL059408-15,NHLBI:146899\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405,,1884066;,"WARSHAW, DAVID M;",,,,Advisory Committees;Budgets;Businesses;Cardiac;Cardiac Myosins;Categories;Communication;Complement;Computer Hardware;Computer software;Computers;data exchange;Electronics;Equipment;Expenditure;Failure (biologic function);Feedback;Fiber;Fostering;Human Resources;Individual;innovation;Institution;instrument;instrumentation;interest;Laboratories;Lasers;Maintenance;Manuscripts;meetings;member;Modification;myosin-binding protein C;Online Systems;Operating System;Peripheral;Personal Computers;Personnel Recruitments;Persons;Principal Investigator;Productivity;programs;Progress Reports;Publishing;Records;Regulation;Research;Research Personnel;Research Project Grants;Schedule;Scientist;Site;Structure;System;Universities;Ventricular;Vermont;Work,ADMINISTRATIVE CORE,59408,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7777,,15,,146899
8611950,P01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,,P01HL059408,,,5P01HL059408-15,NHLBI:439262\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405,,1899370;,"PALMER, BRADLEY M;",,,,Actins;adrenergic;Adrenergic Agents;Affect;Area;Binding (Molecular Function);Binding Sites;Biological Assay;Cardiac;Cardiac Myosins;Catheters;Characteristics;Cyclic AMP-Dependent Protein Kinases;Data;Fiber;Heart;Human;In Vitro;in vivo;indexing;Investigation;Kinetics;Left;Left ventricular structure;Measurement;Measures;Mechanics;Microfilaments;miniaturize;Molecular;Molecular Motors;Mus;Mutation;Myocardial;Myocardium;Myosin ATPase;myosin-binding protein C;Organ;Performance;Phosphorylation;Phosphorylation Site;Physiological;Preparation;pressure;Production;Protein Dephosphorylation;Regulation;Role;Sarcomeres;Serine;Services;single molecule;Site;Skin;Structure;System;Takeda brand of pioglitazone hydrochloride;Testing;Thin Filament;Time;Universities;Ventricular;Vermont;Work,Ventricular and Cardiac Fiber Characterization and Integration Core,59408,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7778,,15,,439262
8611951,P01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,,P01HL059408,,,5P01HL059408-15,NHLBI:244404\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405,,1882725;,"ROBBINS, JEFFREY;",,,,Antibodies;base;Biology;Cardiac Myosins;Cardiovascular system;citrate carrier;design;Equipment and supply inventories;Foundations;Housing;In Vitro;Individual;Maintenance;Medical center;member;Molecular;Mouse Protein;Mus;myosin-binding protein C;Pediatric Hospitals;Preparation;Production;Program Research Project Grants;Protein Fragment;Proteins;Quality Control;Regulation;Research Personnel;Scientist;Shipping;Ships;Structure;System;Transgenic Mice,Mouse and cMyBP-C Protein Production Core,59408,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7779,,15,,244404
8616637,P30,CA,5,N,02/04/2014,02/05/2014,01/31/2015,397,P30CA046934,SCHOOLS OF MEDICINE,PAR-11-005,5P30CA046934-26,NCI:3285657\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,NONE,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE: The NCl-designated Cancer Centers are the centerpiece of the national effort to reduce morbidity and mortality from cancer. As the only NCl-designated Cancer Center in the State of Colorado, the UCCC innovates in the development of more effective approaches to prevention, diagnosis, and therapy of cancer and the deployment of such therapies throughout the state. This application requests renewal of the UCCC's NCl-designated status so we may continue to fight cancer for our community, region, and beyond.",6182841;,"THEODORESCU, DAN;","CIOLINO, HENRY P.",08/06/1997,01/31/2017,Animals;anticancer research;base;Biological Markers;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Cancer stem cell;cancer therapy;Caring;Catchment Area;Cellular biology;Clinical;Clinical Research;Clinical Sciences;Colorado;Communities;Comprehensive Cancer Center;cost;Development;Developmental Therapeutics Program;Diagnosis;DNA Sequence Rearrangement;drug development;Epidermal Growth Factor Receptor;fighting;follower of religion Jewish;Funding;Gap Junctions;Grant;Growth;Head Cancer;Health;health disparity;Health system;Hormones;Hospitals;Human;Image;improved;innovation;Institutes;Institution;Investments;Lead;Malignant neoplasm of lung;Malignant Neoplasms;Marshal;Medical center;medical schools;Medicine;member;Mission;molecular oncology;Morbidity - disease rate;Mortality Vital Statistics;Neck Cancer;Neoplasm Metastasis;Newly Diagnosed;next generation;outreach program;Pathology;Patients;Pediatric Hospitals;Peer Review;Physicians;Population;prevent;Prevention;Prevention approach;Program Development;programs;Publications;Request for Applications;Research;research facility;Research Personnel;Research Project Grants;Resource Development;Resource Sharing;Resources;Role;Scientist;Seeds;Strategic Planning;Structure;survivorship;Therapy Clinical Trials;Training;Translational Research;tumor microenvironment;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Vision;Wyoming,Cancer Center Support Grant,46934,NCI,Subcommittee B - Comprehensiveness,,,26,3285657,
8616638,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:25701\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See instructions):  The Developmental Therapeutics Program (DT) fosters cancer-focused inter-disciplinary research among basic scientists and clinical researchers who are focused on the discovery, development and delivery of new anti-cancer therapies. The Program Leaders promote interaction and collaboration among DT members, which stimulates breakthroughs in diagnosis, treatment and prevention of cancer.",1898896;,"ECKHARDT, S. GAIL;",,,,Adult;AIDS related cancer;Animals;anti-cancer therapeutic;Antineoplastic Agents;Area;base;Basic Science;bench to bedside;Biological Factors;Biological Markers;Biological Models;Biological Products;Biopsy;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Model;Cancer Patient;cancer prevention;cancer therapy;Cancer Therapy Evaluation Program;Categories;Characteristics;Childhood;Clinic;Clinical;Clinical Research;Clinical Services;Clinical Trials;Collaborations;Colorado;Colorectal Cancer;companion animal;Companions;Complement;Complex;Cutaneous;Development;Developmental Therapeutics Program;Diagnosis;Diagnostic;Direct Costs;Disease;drug discovery;Drug Industry;Drug Targeting;Enrollment;Evaluation;Faculty;Focus Groups;Fostering;Functional Imaging;Funding;Goals;Growth;Hematologic Neoplasms;Hepatitis C;Human;Image;Imaging Techniques;Immunotherapy;improved;in vivo;Individual;Industry;Institution;Instruction;Investigation;Laboratories;Laboratory Study;Leadership;leukemia;Magnetic Resonance Imaging;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;Medicine;member;metabolomics;Mission;Modeling;molecular pathology;nanoparticle;Neoplasm Metastasis;Normal tissue morphology;novel;oncology;Pathway interactions;patient population;Patient Selection;Patients;Pediatric Oncology;Pharmacodynamics;Pharmacology;Phase;phase 1 study;Phase I Clinical Trials;Phase III Clinical Trials;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;predictive modeling;Prevention;Process;programs;Publications;Radiation Oncology;Radiation therapy;Radiochemistry;Recombinant Vaccines;Research;Research Personnel;Resistance;Sampling;sarcoma;Science;Scientist;Selection Criteria;Signal Transduction;Source;Southwest Oncology Group;Stem cells;Testing;Therapeutic;therapeutic development;therapeutic target;Training;Translating;Translational Research;Translations;tumor;Tumor Tissue;Validation;Work,DEVELOPMENTAL THERAPEUTICS,46934,NCI,Subcommittee B - Comprehensiveness,8111,,26,,25701
8616639,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:19837\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See instructions):  The Hormone Related Malignancies Program (HRM) fosters cancer-focused inter-disciplinary research among basic scientists, clinical researchers and epidemiologists who study cancers of the reproductive tract and breast The goal is to prevent, diagnose, and treat these cancers more effectively through the translation of lab-based discoveries into therapeutic targets.",2213049;,"HOLT, JEFFREY P;",,,,5 Alpha-Reductase Inhibitor;Address;Animal Model;anticancer research;Apoptosis;Area;base;Biochemical;Biological Markers;Body Fluids;Breast;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cancer stem cell;celecoxib;Characteristics;Clinical;clinical conference;clinical epidemiology;Clinical Trials;Collaborations;Colorado;Complex;Detection;Development;Diagnosis;Direct Costs;Discipline;Disease;Disease Progression;Drug Targeting;Endocrine system;Epidemiologist;epithelial to mesenchymal transition;factor J;Fertilization;Financial Support;Fish Oils;Focus Groups;Fostering;functional genomics;Funding;Goals;Grant;Group Meetings;high throughput screening;hormone therapy;Hormones;improved;Incidence;Inflammatory;Instruction;interest;Joints;Knowledge;Leadership;Light;Link;malignant breast neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mentors;Molecular;Mortality Vital Statistics;Nature;Neoplasm Metastasis;new technology;Newly Diagnosed;novel;novel diagnostics;novel strategies;Pathway interactions;Population;Positioning Attribute;Pregnancy;prevent;Prevention;Preventive;Process;programs;prostate cancer prevention;Prostate Cancer Prevention Trial;Protocols documentation;Publications;Recommendation;Refractory;reproductive;Research;Research Personnel;Research Training;Resistance;Resources;Role;sample collection;Schools;Scientist;screening;Screening for Prostate Cancer;Series;small molecule;Southwest Oncology Group;therapeutic target;Tissues;Training;Translating;Translations;treatment strategy;tumor;tumor microenvironment;tumor progression;Universities;Woman,HORMONE RELATED MALIGNANCIES,46934,NCI,Subcommittee B - Comprehensiveness,8112,,26,,19837
8616640,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:241909\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,1863619;,"BELLGRAU, DONALD;",,,,Cancer Center Support Grant,IMMUNOLOGY-IMMUNOTHERAPY,46934,NCI,Subcommittee B - Comprehensiveness,8113,,26,,241909
8616641,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:63875\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See instructions):  The Molecular Oncology Program (MO) organizes a productive group of researchers whose work provides insights into gene expression regulation and its deregulation in cancer, the cellular response to genomic insults, the molecular structure of cancer-relevant proteins, and new signaling transduction processes driving tumor growth. With the UCCC they translate their basic discoveries into better tools for cancer prevention,  diagnosis and treatment.",1863666;,"GUTIERREZ-HARTMANN, ARTHUR;",,,,Address;anticancer research;Area;Automobile Driving;base;Biological Markers;Biological Process;Cancer Center Support Grant;Cancer Diagnostics;cancer prevention;Cell Cycle Checkpoint;cell fate specification;Cells;Clinic;Clinical Trials;Collaborations;Colorado;combinatorial;Crystallography;Developing Countries;Development;Developmental Therapeutics Program;Diagnosis;DNA;DNA biosynthesis;DNA Repair;DNA-Binding Proteins;Epigenetic Process;Focus Groups;follower of religion Jewish;Funding;Gene Expression;Gene Expression Regulation;Genomics;Goals;Health;Human;human BRAF protein;Human Papilloma Virus Vaccine;insight;Instruction;irradiation;Maintenance;malignant breast neoplasm;Malignant neoplasm of lung;Malignant neoplasm of thyroid;Malignant Neoplasms;member;Molecular;Molecular Biology;molecular oncology;Molecular Structure;Mutagenesis;new technology;novel;novel strategies;Nuclear;Oligopeptides;Oncogene Proteins;Oncogenic;oncology program;Pathway interactions;Physicians;Prevention therapy;Process;programs;Protein Biosynthesis;Protein Kinase;Protein p53;protein structure;Proteins;Proteomics;Publications;Regulation;repaired;Research Personnel;Research Project Grants;Research Support;Resistance;Resources;response;Retrotransposition;RNA;RNA Processing;Schools;Scientist;Series;Signal Pathway;Signal Transduction;Signaling Molecule;small hairpin RNA;structural biology;Structure;symposium;Techniques;Telomerase;tool;Transcription Process;Transcriptional Regulation;Translating;tumor growth;Universities;Work,MOLECULAR &STRUCTURAL BIOLOGY,46934,NCI,Subcommittee B - Comprehensiveness,8114,,26,,63875
8616642,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:25698\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See instructions):  Lung and head and neck cancer are the leading cause of cancer death and the most psychologically distressing cancer, respectively. Both are largely tobacco induced, affect the respiratory tract and share many biologic features. The LHN Program moves basic science findings to clinical practice, exemplified by the discovery of predictive biomarkers to guide therapeutic strategies, early detection and prevention advances and the use of genetic models of cancer to understand the biology of these malignancies.",1917582;,"MILLER, YORK E;",,,,Affect;anticancer research;Area;Basic Science;Behavioral;Biochemical;Biological Markers;Biology;Cancer Biology;Cancer Center Support Grant;cancer diagnosis;Cancer Etiology;cancer risk;Cancer stem cell;career development;Cell Line;Cessation of life;Chemoprevention;Chemopreventive Agent;Chest;Clinical;Clinical Chemoprevention;clinical practice;Clinical Research;Clinical Trials;cohort;Collaborations;Complement;Coupling;design;Development;Distress;Drug Targeting;Dysplasia;Early Diagnosis;Environmental Risk Factor;Epidermal Growth Factor Receptor;Epigenetic Process;Epithelial-Stromal Communication;Experimental Models;Focus Groups;Fostering;fundamental research;Funding;Genetic;Genetic Models for Cancer;Genetically Engineered Mouse;Goals;Grant;Head and Neck Cancer;Head and Neck Neoplasms;Head and neck structure;high risk;Histone Deacetylase;Iloprost;Immune system;Incidence;Individual;insight;Institution;Instruction;interest;Lead;Lower respiratory tract structure;Lung;Malignant neoplasm of lung;Malignant Neoplasms;meetings;member;Modeling;Molecular;Molecular Epidemiology;Mortality Vital Statistics;mouse model;Mutation;Neoplasm Metastasis;novel;novel therapeutics;Patients;Pharmaceutical Preparations;Phase;Pilot Projects;Population;pre-clinical;Prevention;Preventive;Preventive Intervention;Process;prognostic;programs;Proteins;Publications;Recruitment Activity;Research;Research Personnel;Research Support;Resistance;Resources;Respiratory System;Respiratory tract structure;Risk;Sampling;Schools;Scientist;Series;Somatic Mutation;Specimen;success;Techniques;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Studies;Time;Tissues;Tobacco;tool;Training;Translating;translational study;Treatment Efficacy;tumor;tumor xenograft;Validation;working group;Xenograft Model;Xenograft procedure,"LUNG, HEAD AND NECK CANCERS",46934,NCI,Subcommittee B - Comprehensiveness,8115,,26,,25698
8616643,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:194919\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See Instructions):  The University of Colorado Cancer Center (UCCC) is organized into six research programs, each of which is headed by two co-leaders.",1860776;,"BUNN, PAUL A.;",,,,anticancer research;Basic Science;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Cellular biology;Clinical Sciences;Collaborations;Colorado;Communication;Complement;Developmental Therapeutics Program;Doctor of Philosophy;Educational Activities;Evaluation;Faculty;Fostering;Grant;Growth;Head;Head and neck structure;Hormones;Individual;Institutes;Institution;Instruction;Interdisciplinary Study;Leadership;Lung;Malignant Neoplasms;member;Mentors;molecular oncology;Performance;Pilot Projects;Population Sciences;posters;programs;Reporting;Research;Resource Sharing;Schools;Strategic Planning;Structure;symposium;Talents;The University of Colorado Cancer Center;Training Programs;Universities,PROGRAM LEADERS,46934,NCI,Subcommittee B - Comprehensiveness,8117,,26,,194919
8616644,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:45281\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See Instructions):  Research Staff Investigators (SI) are important contributors to the programmatic and translational activities of the Cancer Center. The UCCC has 3 Si's in cancer immunology, pediatric oncology/stem cells and cancer survivorship to promote those research themes across the scientific programs and advance the development of new programs in the areas of Cancer Stem Cells, Metastasis and Tumor Microenvironment, and Cancer Survivorship.",1860776;,"BUNN, PAUL A.;",,,,"Advanced Development;Affect;Area;Cancer Center;Cancer Center Support Grant;Cancer Immunology Science;Cancer stem cell;Cancer Survivorship;Cells;Clinic;Clinical Trials;Collaborations;Continuance of life;Development;experience;Funding;Goals;Hunger;Immunological Models;Inflammatory;Instruction;Knowledge;Late Effects;Leukemia, Lymphocytic, Acute, L1;Neoplasm Metastasis;Oncologist;oncology;Palliative Care;Pediatric Oncology;Peer Review;programs;Publications;Regenerative Medicine;Research;Research Activity;research and development;Research Personnel;Role;stem cell therapy;Stem cells;survivorship;Translational Research;Transplantation;tumor;tumor microenvironment;tumor progression;Virginia",STAFF INVESTIGATORS,46934,NCI,Subcommittee B - Comprehensiveness,8118,,26,,45281
8616645,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:4803\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See instructions):  NCl-designated Cancer Centers are the centerpiece of the national effort to reduce morbidity and mortality from cancer. As an NCl-designated Comprehensive Cancer Center, the University of Colorado Cancer Center (UCCC) is dedicated to the mission of developing more effective approaches to prevention, diagnosis, and therapy. Planning and Evaluation efforts of the UCCC provide the means through which strategic decision-making and subsequent implementation are conducted to accomplish the UCCC mission.",1860776;,"BUNN, PAUL A.;",,,,Advisory Committees;anticancer research;Appointment;Area;base;Basic Science;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Clinical Sciences;Clinical Services;Colorado;Commit;Communities;Complement;Comprehensive Cancer Center;cost;Counseling;Critiques;Decision Making;Development;Diagnosis;Educational aspects;Evaluation;Evaluation Research;Funding;Goals;Grant;Individual;insight;Institution;Instruction;Leadership;Lung;Malignant Neoplasms;meetings;member;Mission;Monitor;Morbidity - disease rate;Mortality Vital Statistics;NCI-Designated Cancer Center;Play;Prevention approach;Process;Program Development;programs;Protocols documentation;Recommendation;Research;Resource Allocation;Resource Sharing;Role;Seeds;Series;Source;Strategic Planning;symposium;The University of Colorado Cancer Center;Travel;Universities;Vision;Visit,PLANNING-EVALUATION,46934,NCI,Subcommittee B - Comprehensiveness,8119,,26,,4803
8616646,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:458345\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See instructions):  An NCl-designated Comprehensive Cancer Center, the UCCC is dedicated to the discovery of the nature of cancer and the development of more effective approaches to prevention, diagnosis and therapy. The requested Developmental funds provide flexibility to recruit faculty, fund pilot grants, and develop shared resources that strengthen the UCCC's research programs.",1860776;,"BUNN, PAUL A.;",,,,Animals;Area;base;Basic Science;Budgets;cancer cell;Cancer Center;Cancer Center Support Grant;Categories;Cellular biology;Collaborations;Comprehensive Cancer Center;Development;Diagnosis;Evaluation;Faculty;flexibility;Funding;Funding Agency;Grant;Human;Image;Immunologist;innovation;Instruction;malignant breast neoplasm;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Nature;Neoplasm Metastasis;pre-clinical;Prevention approach;programs;Recruitment Activity;Research;Research Personnel;Resource Sharing;Services;tumor microenvironment,DEVELOPMENTAL FUNDS,46934,NCI,Subcommittee B - Comprehensiveness,8120,,26,,458345
8616648,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:23167\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,RELEVANCE (See instructions):  The Cancer Cell Biology Program organizes UCCC researchers who study how cellular processes function in the development and progression of cancer. Understanding how cancer changes the way cells function can help biomedical researchers discover new ways to prevent and treat it.,1887801;,"SCLAFANI, ROBERT A;",,,,Address;adult stem cell;Affect;Animal Model;anticancer research;Apoptosis;Area;Autophagocytosis;Biological Markers;Biological Models;Biological Process;Budgets;cancer cell;Cancer Center Support Grant;cancer chemoprevention;Cancer Control;Cancer Patient;Cancer stem cell;cancer therapy;cancer type;Cancer Vaccine Related Development;Cancerous;cell behavior;Cell Cycle;Cell Cycle Regulation;Cell Death;Cell Differentiation process;Cell division;cell growth;Cell physiology;Cells;Cellular biology;Cellular Immunity;Chemopreventive Agent;Clinical Trials;Collaborations;Colorado;Cutaneous Melanoma;cytokine;Defect;Development;Direct Costs;DNA biosynthesis;Drug Targeting;epigenetic marker;Epigenetic Process;Epithelial;Focus Groups;follower of religion Jewish;frontier;functional genomics;Funding;Future;gain of function mutation;Genetic;Gifts;Goals;Grant;Growth and Development function;Head and Neck Cancer;Health;Histone H3;Immune response;Immune system;Immunity;improved;Inflammation;Inflammatory Response;Instruction;Knowledge;Life;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;malignant phenotype;man;Mediating;melanoma;member;Mesenchymal;migration;Mitosis;Modification;Molecular;Neoplasm Metastasis;neoplastic cell;new technology;Normal Cell;novel;novel diagnostics;novel strategies;novel therapeutics;Oncogenes;outcome forecast;Paper;Pathway interactions;Peer Review;Pharmaceutical Preparations;Physicians;Preclinical Drug Evaluation;prevent;Prevention strategy;Process;Production;programs;Proteins;Publications;Publishing;Rana (genus);Recruitment Activity;Regenerative Medicine;Regulation;Research;Research Personnel;Resources;response to injury;Role;Schools;Scientist;Screening for cancer;Signal Transduction;silibinin;Skin;Skin Carcinoma;stem cell biology;Stem Cell Development;Stem cells;Technology;Testing;Therapeutic;therapeutic target;Tissues;Translating;tumor;tumor progression;Universities;Work,CANCER CELL BIOLOGY,46934,NCI,Subcommittee B - Comprehensiveness,8121,,26,,23167
8616647,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:25698\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,802141433,"RELEVANCE (See instructions):  To further reduce the cancer burden in the U.S., a robust program of research and translational science in cancer prevention and control is needed, which this program provides to UCCC, the State of Colorado and beyond.",6917161;,"MARCUS, AL;",,,,ActiVin (Grape Seed Extract);African American;Animal Model;Area;base;Behavioral;Behavioral Research;Breast Cancer Risk Factor;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer epidemiology;cancer prevention;Cancer Survivor;Cancer Survivorship;Chemoprevention;Child;childhood cancer survivor;Clinical Trials;Cognitive remediation;Colon Carcinoma;Colorado;Colorectal Cancer;colorectal cancer screening;Communities;Consumption;Counseling;Development;Diet and Nutrition;dissemination research;effective intervention;Focus Groups;fruits and vegetables;Funding;Goals;Health;health disparity;Incidence;Industry;Instruction;Laboratory Research;Latina;Latino;malignant breast neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medical center;member;Morbidity - disease rate;Mortality Vital Statistics;Native Americans;Nevus;oncology;Outcome;Paper;Pediatric Hospitals;Peer Review;Physical activity;Population;Population Sciences;Primary Prevention;Printing;programs;Property;psychosocial;Publications;Publishing;Recreation;Research;Schools;Science;Secondary Prevention;Services;silibinin;Site;smoking cessation;sun protection;survivorship;Telephone;tobacco control;Translational Research;United States Department of Veterans Affairs;Universities;Wolves,PREVENTION-CONTROL,46934,NCI,Subcommittee B - Comprehensiveness,8122,,26,,25698
8616650,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:149171\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See instructions):  The Protocol Specific Research component of a Cancer Center Support Grant provides specific support for short-term, feasibility (i.e. pre-phase 1 and pilot) and phase I clinical trials that originate with the investigators at the University of Colorado Cancer Center. This support allow investigators to test novel ideas and generate preliminary data that can be used as the basis for later phase trials funded through competitive grant applications, cooperative groups or industry.",1861679;,"KANE, MADELEINE A;",,,,abstracting;Applications Grants;base;Budgets;Cancer Center Support Grant;cancer therapy;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Data;data management;design;Detection;Development;Devices;Diagnosis;Drug Kinetics;Eligibility Determination;Endowment;Foundations;Funding;Goals;Grant;Growth;Industry;innovation;Instruction;International;Intervention;Lead;Manuscripts;meetings;member;Notification;novel;Outcome;Patient Care;Patients;Peer Review;Peer Review Grants;Phase;Phase I Clinical Trials;Physician Executives;Preparation;Prevention;Process;programs;protocol development;Protocols documentation;Publishing;Radiation Therapy Oncology Group;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;sample collection;Services;Southwest Oncology Group;success;Testing;The University of Colorado Cancer Center;Time;Visit;Workload;Writing,PROTOCOL SPECIFIC RESEARCH,46934,NCI,Subcommittee B - Comprehensiveness,8124,,26,,149171
8616651,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:60711\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See Instructions):  At the University of Colorado Cancer Center (UCCC) we take patient research (clinical trials) safety very seriously. We have specific body called the Quality Assurance (QA) / Data Safety Monitoring (DSM)for this purpose. The mission of QA DSM Shared Resource is to insure the highest quality, safest, most precisely performed clinical cancer research at the UCCC grant applications or industry.",1861679;,"KANE, MADELEINE A;",,,,Achievement;Advisory Committees;anticancer research;Applications Grants;Cancer Center;Cancer Center Support Grant;Clinical;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Colorado;Continuing Education;Data;Disorder by Site;Doctor of Philosophy;Educational aspects;Ethics;Funding;Goals;human subject;Human Subject Research;improved;Industry;Institutes;Institution;Instruction;Knowledge;Medical;medical schools;member;Mission;Monitor;Patients;Process;programs;Protocols documentation;quality assurance;Regulatory Affairs;Reporting;Research;Research Personnel;Resource Sharing;Safety;Services;Structure;The University of Colorado Cancer Center;Training;Training Programs;Translational Research;Universities,DATA SAFETY &MONITORING/ QUALITY ASSURANCE,46934,NCI,Subcommittee B - Comprehensiveness,8125,,26,,60711
8616652,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:102334\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,2062732;,"ELIAS, ANTHONY D;",,,,Agreement;analytical tool;Animal Model;Cancer Center;Cancer Center Support Grant;Cell Line;Clinical;Collaborations;Common Data Element;computerized data processing;Data;Data Collection;Data Set;Data Sources;Documentation;Epidemiology;Guidelines;informatics shared resource;Mediation;Names;Policies;pre-clinical;Publications;Research;Research Support;Seminal;sharing data;Specimen;Technology Transfer;The University of Colorado Cancer Center;Tissues;United States National Institutes of Health,DATA SHARING,46934,NCI,Subcommittee B - Comprehensiveness,8126,,26,,102334
8616653,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:302220\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,RELEVANCE (See instructions):  The Clinical Investigations Core Shared Resource (CICSRSR) provides support to clinical investigators on all activities related to the successful conduct of clinical trial research. This is the cornerstone to translate basic science knowledge of the cancer process into clinically useful treatments for patients.,1861679;,"KANE, MADELEINE A;",,,,Basic Science;Cancer Center Support Grant;Clinical Investigator;Clinical Trials;Conduct Clinical Trials;Instruction;Knowledge;Malignant Neoplasms;Mission;Patients;Process;Research;Resource Sharing;Translating,CLINICAL INVESTIGATIONS CORE,46934,NCI,Subcommittee B - Comprehensiveness,8127,,26,,302220
8616654,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:353069\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,2094301;,"VARELLA-GARCIA, MARILEILA;",,,,anticancer research;Award;biobank;Biological Assay;Biological Markers;Cancer Center;Cancer Center Support Grant;cancer therapy;Cell Line;Classification;Clinical;Clinical Sciences;Clinical Services;Colorado;Cytogenetics;Development;Diagnosis;DNA;DNA Sequence;DNA Sequence Analysis;Ensure;Evaluation;Institution;Leadership;member;Microdissection;Molecular;Molecular Cytogenetics;molecular marker;molecular pathology;Mutation;Outcome;Pathology;Process;prognostic;Provider;Recording of previous events;repository;Research;Research Activity;Research Personnel;Resistance;Resource Sharing;Resources;response;Services;Solid Neoplasm;Specimen;success;Technology;Testing;Therapeutic Agents;Tissue Banking;Tissue Banks;Tissues;Translational Research;tumor;Validation;Work,CYTOGENETICS CORE,46934,NCI,Subcommittee B - Comprehensiveness,8129,,26,,353069
8616655,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:51756\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See instructions):  Using flow cytometric analysis, high-speed cell sorting, microscopy, and multiplexed fluorescent microsphere assays, the Flow Cytometry Shared Resource can perform a wide range of assays supporting cancer research, including cell cycle, cell proliferation, apoptosis, cell viability, cell signaling, stem cell detection,  fluorescent protein analysis, and cell phenotyping. These assays are crucial to understanding how cancer derails normal cellular processes to cause disease.",8440843;,"REARDON, CHRISTOPHER LEE;",,,,anticancer research;Apoptosis;Apoptotic;Back;base;Biological Assay;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Research Project;Cell Cycle;Cell physiology;Cell Proliferation;Cell Separation;Cell Survival;Cells;Charge;Clinical;Color;Colorado;Consult;Consultations;cost effective;Cytometry;design;Detection;Development;Disease;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Hour;Housing;Image;Immunology;In Vitro;in vivo;in vivo Model;Institution;Instruction;Laboratories;Malignant Neoplasms;member;Microscope;Microscopy;Microspheres;neoplastic cell;Phenotype;Population;programs;Protein Analysis;Research;Research Personnel;research study;Resource Sharing;Resources;response;Scanning;Services;Signal Transduction;Source;Speed (motion);stem cell population;Stem cells;System;Techniques;Technology;The University of Colorado Cancer Center;Tissues;tool;Training;tumor;Tumor Stem Cells;Universities,FLOW CYTOMETRY CORE,46934,NCI,Subcommittee B - Comprehensiveness,8130,,26,,51756
8616656,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:134853\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,1991834;,"STEVENS, JAMES O;",,,,Cancer Center Support Grant,LABORATORY ANIMAL CORE,46934,NCI,Subcommittee B - Comprehensiveness,8131,,26,,134853
8616657,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:136832\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,RELEVANCE (See instructions):  The Protein Production / Monoclonal Antibody / Tissue Culture Shared Resource provides a centralized services to make cancer-related proteins for UCCC members to study their mechanism of action in identified drugs and cancer-related biomarkers.,1877170;,"EDWARDS, DEAN P;",,,,anticancer research;Antigens;Back;Baculoviruses;Basic Science;Biochemical;Biological Assay;Biological Markers;Bioreactors;Budgets;Cancer Center Support Grant;Cell Culture Techniques;Cell Line;Cells;Charge;Communities;Consultations;cost;cost effective;drug related cancer;Enzyme-Linked Immunosorbent Assay;Funding;Generations;Human;hybridoma production;Hybridomas;Incubators;Individual;Insecta;Institution;Instruction;interest;Liquid substance;Malignant Neoplasms;meetings;member;Molecular;Monoclonal Antibodies;monoclonal antibody production;Nitrogen;novel;Preparation;Production;programs;Property;protein expression;Proteins;Reader;Reagent;Recombinant Proteins;Recombinants;Research;Research Personnel;Resources;Services;Source;System;Technology;tissue culture;Tissue Culture Shared Resource;Training;Translational Research;Tumor Cell Line;Validation;vector,TISSUE CULTURE/ MAb CORE,46934,NCI,Subcommittee B - Comprehensiveness,8132,,26,,136832
8616658,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:3231\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,1885652;,"DRABKIN, HARRY A.;",,,,Alleles;anticancer research;Award;base;biobank;Biological Assay;Blood capillaries;Cancer cell line;Cancer Center;Cancer Center Support Grant;capillary;Clinical;Clinical Sciences;Clinical Services;Cloning;Colorado;Computer software;Consult;Cytogenetics;design;Development;Diagnosis;DNA;DNA analysis;DNA Fingerprinting;DNA Sequence;DNA Sequence Analysis;Evaluation;Gene Dosage;gene function;Gene Mutation;Genes;Human;Institution;instrument;Leadership;Ligation;member;Microdissection;Modeling;Molecular;Molecular Cytogenetics;molecular pathology;Mutation;Pathology;Process;Provider;rapid detection;Recording of previous events;repository;Research Activity;Research Personnel;Resource Sharing;Resources;response;Services;Structure;success;Technology;Testing;Therapeutic Agents;Tissue Banking;Tissue Banks;Tissues;Translational Research;Validation;Walking,DNA SEQUENCING &ANALYSIS CORE,46934,NCI,Subcommittee B - Comprehensiveness,8133,,26,,3231
8616659,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:120245\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,1887562;,"GERACI, MARK W;",,,,Cancer Center Support Grant,GENE EXPRESSION CORE,46934,NCI,Subcommittee B - Comprehensiveness,8134,,26,,120245
8616661,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:125519\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"The Pharmacology Shared resource gathers technology and expertise to fully support pharmacology  aspects of UCCC members'preclinical or clinical research, including pharmacokinetic (PK) study design,  analytical assay design and development appropriate for measuring drugs in biological samples, expertise in  animal dosing and sampling, and PK modeling.",1889669;,"GUSTAFSON, DANIEL L;",,,,analytical method;Animals;Back;base;Basic Science;Biochemical;Biological;Biological Assay;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Charge;Clinical Protocols;Clinical Research;Colorado;Consultations;Data;design;Detection;Development;Developmental Therapeutics Program;Dose;Drug Kinetics;Enzyme-Linked Immunosorbent Assay;Fluorescence;Head Cancer;High Pressure Liquid Chromatography;Hormones;Housing;Institution;instrument;Liquid substance;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical;member;Methodology;Methods;Modeling;Neck Cancer;Pharmaceutical Preparations;pharmacokinetic model;Pharmacology;Pharmacology Shared Resource;population based;pre-clinical research;Procedures;programs;quality assurance;Research Design;Research Personnel;Research Project Grants;research study;Resources;Sampling;Services;System;tandem mass spectrometry;Technology;Tissues;Universities;Validation,PHARMACOLOGY CORE,46934,NCI,Subcommittee B - Comprehensiveness,8135,,26,,125519
8616660,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:84232\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,802141433,,6917161;,"MARCUS, AL;",,,,Cancer Center Support Grant,SURVEY RESEARCH CORE,46934,NCI,Subcommittee B - Comprehensiveness,8137,,26,,84232
8616665,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:177681\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,2408392;,"FRANKLIN, WILBUR A;",,,,Archives;base;biobank;Biological Assay;Cancer Center;Cancer Center Support Grant;Cell Separation;Cells;Cetuximab;Client;Clinical;Clinical Research;Colon Carcinoma;Colorado;Computers;Databases;Diagnosis;DNA;DNA Sequence;Ensure;Equipment;Evaluation;exome;Funding;Future;Image;image processing;informatics shared resource;KRAS2 gene;Laboratories;Liquid substance;Maintenance;Malignant neoplasm of lung;Materials Testing;member;Methods;Microdissection;Microscope;Molecular;Multicenter Trials;Mutation;neoplastic cell;Nucleic Acids;Outcome;Pathology;Preparation;Process;Reporting;Research;Research Activity;Resource Sharing;Retrieval;Reverse Transcriptase Polymerase Chain Reaction;Robot;Sampling;Scorpions;Services;Slide;Specimen;System;Technology;Test Result;Testing;Tissues,PATHOLOGY CORE,46934,NCI,Subcommittee B - Comprehensiveness,8138,,26,,177681
8616663,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:222043\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,6477752;,"DUNCAN, MARK WILLIAM;",,,,Cancer Center Support Grant,PROTEOMICS CORE,46934,NCI,Subcommittee B - Comprehensiveness,8139,,26,,222043
8616666,P30,CA,5,N,02/04/2014,02/01/2014,01/31/2015,,P30CA046934,,PAR-11-005,5P30CA046934-26,NCI:132527\,Research Centers,2014,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"RELEVANCE (See Instructions):  Researchers in the Structural Biology Shared Resource determine the 3-dimensional structures of the proteins, other cellular macromolecules and their complexes that affect the development and progression of cancer, and of small molecules, potential drugs and their interactions with their therapeutic targets.  Structures of molecules implicated in cancer provide clues to potential therapies.",1964510;,"CHURCHILL, MAIR E;",,,,Accounting;Affect;American Cancer Society;anticancer research;Area;base;Budgets;Cancer Center Support Grant;cancer pharmacology;Cell physiology;Cell surface;Cells;Chromatin Assembly and Disassembly;Clinical Research;Colorado;Complement;Complex;computerized data processing;Consultations;Core Facility;Crystallization;Data;Data Collection;detector;Development;Direct Costs;Drops;Drug Design;follower of religion Jewish;Foundations;Funding;Future;Genetic Transcription;Grant;Health;Hormone Receptor;Human Resources;Image;Institution;Instruction;instrument;instrumentation;Journals;macromolecule;Malignant Neoplasms;Medical;member;Molecular;Molecular Biology;Nature;neoplastic cell;NMR Spectroscopy;operation;Pharmaceutical Preparations;Phospholipids;Preparation;Production;programs;Proteins;Publications;Research;Research Personnel;Resource Sharing;Resources;Robotics;Roentgen Rays;Sampling;Science;Services;Signal Transduction;small molecule;structural biology;Structure;System;Technology;telomere;therapeutic target;three dimensional structure;Training;tumor progression;Tumor Suppressor Proteins;United States National Institutes of Health;Universities;Validation;X-Ray Crystallography,STRUCTURAL BIOLOGY CORE,46934,NCI,Subcommittee B - Comprehensiveness,8140,,26,,132527
8650796,P30,DA,5,N,02/04/2014,01/01/2014,12/31/2014,279,P30DA011041,SCHOOLS OF NURSING,PAR-10-220,5P30DA011041-17,NIDA:1211372\,Research Centers,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,NONE,12,041968306,US,NEW YORK UNIVERSITY,NY,100122331,"PUBLIC HEALTH RELEVANCE: Substance use remains a critical influence on the HIV epidemic, impacting incidence and compromising the benefits of HIV treatment. The Center provides a research infrastructure to enhance productivity and synergy across investigators working to meet the goals of the National HIV/AIDS Strategy. It will also enhance the research translation process so that findings are more rapidly brought from discovery to public health impact.",1868037;,"DEREN, SHERRY;","LAMBERT, ELIZABETH ",04/15/1999,12/31/2017,Address;Affect;Aging;AIDS prevention;AIDS/HIV problem;Alcohol or Other Drugs use;Area;Back;base;Behavioral;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Charge;Collaborations;college;Communicable Diseases;Communities;Comorbidity;comparative effectiveness;Complex;Country;Criminal Justice;Development;Discipline;Discipline of Nursing;Drug usage;Economics;effective intervention;effectiveness research;Environment;Epidemic;Ethnicity aspects;experience;Face;Gender;Goals;Growth;Health;health care delivery;health disparity;Health Services Accessibility;HIV;improved;Incidence;Infection;innovation;Institution;Interdisciplinary Study;International;Intervention;Intervention Studies;Knowledge;Life;Light;meetings;Mentors;Methods;Morbidity - disease rate;Mortality Vital Statistics;Outcome;Phase;Pilot Projects;Population;Prevention;Productivity;Provider;Public Health Applications Research;public health medicine (field);Public Health Practice;Race;ranpirnase;Reporting;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Role;scale up;Scientist;Services;social;socioeconomics;Source;Structure;theories;tool;Translation Process;Translational Research;Work,Discovery to Implementation &Back: Research Translation for the HIV/SU Epidemic,11041,ZDA1,Special Emphasis Panel,,,17,1211372,
8650797,P30,DA,5,N,02/04/2014,01/01/2014,12/31/2014,,P30DA011041,,PAR-10-220,5P30DA011041-17,NIDA:317310\,Research Centers,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,12,041968306,US,NEW YORK UNIVERSITY,NY,100122331,,1868037;,"DEREN, SHERRY;",,,,Address;AIDS prevention;Awareness;Back;base;Caring;Collaborations;Communities;contextual factors;Discipline;Ensure;Environment;Epidemic;Feedback;Fostering;Goals;Health;health disparity;HIV;Individual;innovation;Institution;Interdisciplinary Study;International;Joints;Knowledge;Leadership;meetings;member;Mentors;Methods;Modeling;novel strategies;organizational structure;Policies;Policy Maker;Productivity;Professional Education;Provider;public health medicine (field);Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Services;social;Source;Structure;Training;Translational Research;Work,Administrative Core,11041,ZDA1,Special Emphasis Panel,5116,,17,,317310
8650798,P30,DA,5,N,02/04/2014,01/01/2014,12/31/2014,,P30DA011041,,PAR-10-220,5P30DA011041-17,NIDA:150209\,Research Centers,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,12,041968306,US,NEW YORK UNIVERSITY,NY,100122331,,1888398;,"FRIEDMAN, SAMUEL R;",,,,Acute;Address;Adherence (attribute);Affect;AIDS prevention;Alcohol or Other Drugs use;antiretroviral therapy;Back;base;Behavior Therapy;Behavioral;Caring;Clinical;Clinical Sciences;Communities;Consultations;Data Set;Development;Discipline;Disease;Disease Outbreaks;Economics;Effectiveness;Environment;Epidemic;Epidemiology;Face;falls;firewall;Goals;Graph;health disparity;Health Services Accessibility;high risk;HIV;HIV Infections;HIV risk;improved;Individual;innovation;Intervention;Knowledge;Lead;mathematical model;Measures;Methods;microbicide;Modeling;network models;Organizational Change;Outcome;Population;prevent;Prevention;Prevention approach;Prevention strategy;Process;programs;psychologic;psychosocial;Regimen;Relative (related person);Reliance;Research;Research Design;Research Personnel;Scientific Advances and Accomplishments;simulation;social;socioeconomics;Structure;Techniques;Testing;Theoretical model;theories;Therapeutic;Time;Training;Translating;Translational Research;transmission process;treatment strategy;Unsafe Sex;Vaccines;Variant;Viral Load result,Transdisciplinary Theoretical Svnthesis and Development Core,11041,ZDA1,Special Emphasis Panel,5119,,17,,150209
8650800,P30,DA,5,N,02/04/2014,01/01/2014,12/31/2014,,P30DA011041,,PAR-10-220,5P30DA011041-17,NIDA:136326\,Research Centers,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,12,041968306,US,NEW YORK UNIVERSITY,NY,100122331,,8360177;,"PERLMAN, DAVID C;",,,,Address;Affect;Aging;Agonist;AIDS prevention;Alcohol consumption;Alcohol or Other Drugs use;Alcohols;Anti-Retroviral Agents;antiretroviral therapy;Antiviral Agents;Area;Back;base;Bathing;Behavioral;behavioral health;Behavioral Research;Biomedical Research;Candy;Caring;CD4 Lymphocyte Count;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;Communicable Diseases;Comorbidity;Complex;Consultations;County;Data;Development;Discipline;Disease Progression;Drug abuse;Drug usage;Drug user;Educational aspects;effective intervention;Effectiveness;Epidemic;Epidemiology;Fostering;Genomics;health care delivery;health care service organization;Health Insurance;Health Policy;Health Services;Health Services Accessibility;Healthcare;Hepatitis C;Hepatitis C Transmission;Hepatitis C virus;Heterosexuals;high risk;HIV;HIV drug resistance;HIV Infections;HIV-1;Illicit Drugs;improved;Individual;Infection;Interferons;Intervention;Knowledge;knowledge base;Life;Life Expectancy;Literature;Liver diseases;Longevity;Male Circumcision;Medicine;member;Methadone;Minority Groups;Modeling;Morbidity - disease rate;Mortality Vital Statistics;multidisciplinary;Natural History;Opioid;Opportunistic Infections;Oral;Outcome;Participant;Pathogenesis;Pattern;Persons;Pharmaceutical Preparations;Phase;Population;prevent;Prevention;Prevention program;Prevention strategy;Quality of life;Research;Research Personnel;Research Training;Resources;Ribavirin;Risk;Risk Factors;Role;Salts;Salvia;Science;service intervention;Sexual Transmission;skills;social;Substance Use Disorder;substance use prevention;success;Syringes;Testing;tool;Training;Translational Research;Translations;transmission process;treatment program;treatment strategy;trend;Virus;Virus Diseases;Work;Xylazine,Infectious Diseases and Biomedical Core,11041,ZDA1,Special Emphasis Panel,5121,,17,,136326
8650801,P30,DA,5,N,02/04/2014,01/01/2014,12/31/2014,,P30DA011041,,PAR-10-220,5P30DA011041-17,NIDA:198498\,Research Centers,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,12,041968306,US,NEW YORK UNIVERSITY,NY,100122331,,1870157;,"HAGAN, HOLLY C.;",,,,Address;Affect;Area;Awareness;Back;Caring;clinical care;Collaborations;Communicable Diseases;cost effective;Development;Discipline;disorder control;disorder prevention;Drug Formulations;effective intervention;Epidemic;Epidemiology;Ethics;evidence base;Evidence based practice;experience;Funding;Goals;health disparity;HIV;Infectious Disease Epidemiology;innovation;insight;interest;Intervention;investigator training;Knowledge;Measures;method development;Methodology;Methods;Modeling;Pathway interactions;Phase;Population;Prevention;Process;Protocols documentation;public health medicine (field);Research;research and development;Research Design;Research Methodology;Research Personnel;research study;Resources;Rest;routine practice;Sampling;skills;socioeconomics;Source;Staging;Structure;Testing;theories;therapy design;Training Support;Translational Research;Translations;Variant;Vulnerable Populations;Work,Transdisciplinary Research Methods Core,11041,ZDA1,Special Emphasis Panel,5122,,17,,198498
8650802,P30,DA,5,N,02/04/2014,01/01/2014,12/31/2014,,P30DA011041,,PAR-10-220,5P30DA011041-17,NIDA:213931\,Research Centers,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,12,041968306,US,NEW YORK UNIVERSITY,NY,100122331,,9037812;,"BRAITHWAITE, RONALD SCOTT;",,,,Accounting;Acquired Immunodeficiency Syndrome;Address;Adopted;Affect;African American;AIDS diagnosis;Alcohol or Other Drugs use;Alcohols;Attention;authority;Back;base;Biological Testing;brief intervention;Budgets;care delivery;Caring;Cessation of life;Clinical;Clinical Research;Clinical Trials Design;combat;Communities;comparative effectiveness;compare effectiveness;Complex;condoms;constriction;Consultations;Cost Effectiveness Analysis;Databases;Decision Analysis;Decision Making;demographics;Development;Diagnosis;Economics;effective intervention;Effectiveness of Interventions;effectiveness research;Enrollment;Environment;Epidemic;Generations;Goals;head-to-head comparison;Health;Health Benefit;health care delivery;health disparity;Health Policy;Health Services;Healthcare;Healthcare Systems;High Prevalence;Hispanics;HIV;HIV Infections;Human immunodeficiency virus test;implementation science;improved;Incidence;Individual;innovation;Institute of Medicine (U.S.);Intervention;Intervention Studies;investigator training;Knowledge;Link;literacy;mathematical model;Medicine;men;Mental Health;Methods;Minority;Modeling;Monitor;Morbidity - disease rate;Mortality Vital Statistics;New York City;Operations Research;opportunity cost;Outcome;patient population;Patients;Persons;Phase;phrases;Play;Policy Maker;Population;prevent;Prevention;programs;public health medicine (field);public health research;Reporting;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk;Risk Behaviors;Risk Factors;Role;Shorthand;Small Business Technology Transfer Research;Solutions;Staging;Subgroup;successful intervention;Syringes;System;systematic review;Time;tool;Training;Training Support;Translational Research;transmission process;uptake;Woman;Work,Comparative Effectiveness Research Core,11041,ZDA1,Special Emphasis Panel,5123,,17,,213931
8650803,P30,DA,5,N,02/04/2014,01/01/2014,12/31/2014,,P30DA011041,,PAR-10-220,5P30DA011041-17,NIDA:195098\,Research Centers,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,12,041968306,US,NEW YORK UNIVERSITY,NY,100122331,,2226606;,"GUILAMO-RAMOS, VINCENT M;",,,,Address;Advertising;Alcohol or Other Drugs use;Area;Back;base;career;career development;Categories;Collaborations;Data;Development;Ensure;Epidemic;Evaluation;experience;Extramural Activities;Fostering;Funding;Goals;Grant;HIV;innovation;Institution;investigator training;Literature;Mentors;Mentorship;National Institute of Drug Abuse;novel;pandemic disease;Pilot Projects;Research;Research Personnel;Research Support;Role;Scientist;Staging;Structure;success;Testing;Training;Translational Research;United States National Institutes of Health,Pilot Proiects and Mentoring Core,11041,ZDA1,Special Emphasis Panel,5125,,17,,195098
8609593,P30,MH,5,N,02/03/2014,02/01/2014,01/31/2015,242,P30MH043520,,PAR-11-019,5P30MH043520-26,NIMH:1574984\,Research Centers,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,10032,"PUBLIC HEALTH RELEVANCE: New York City home to over a third of people living with HIV/AIDS in the US - has the highest number of new infections of any US city and large ethnic/racial minority populations coping with extreme economic and health disparities. From this US HIV epicenter, the HIV Center works in four continents to conduct leading research and build the capacity of scientists, advocates, practitioners, and policy-makers to decrease the impact of HIV/AIDS on individuals and communities. Our work will contribute to the actualization of the US National HIV/AIDS Strategy and provide public health practice models for the US and the world.",1887216;,"REMIEN, ROBERT H;","GORDON, CHRISTOPHER M.",09/30/1987,01/31/2018,Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Adherence (attribute);Advocate;AIDS prevention;AIDS/HIV problem;Anti-Retroviral Agents;Area;base;Behavioral;behavioral/social science;biobehavior;Caring;Cities;Clinical;college;Commit;Communities;community based participatory research;Community Health;coping;data management;Development;Early treatment;Economics;Ensure;Environment;Epidemic;Epidemiology;Ethical Analysis;Ethics;experience;Fertilization;fight against;Gender;Generations;Health;health disparity;Health Policy;health science research;HIV;Home environment;implementation science;improved;Individual;Infection;Information Technology;innovation;Institutes;Interdisciplinary Study;International;Intervention;Lead;Leadership;Life;Male Circumcision;Medical;Medicine;Mental Health;Minority Groups;Modeling;multidisciplinary;National Institute of Mental Health (U.S.);New York;New York City;operation;Oral;Outcome;Peer Review;Pharmaceutical Preparations;Policies;Policy Analysis;Policy Maker;Population;prevent;Prevention;Prevention strategy;Prophylactic treatment;Psychiatry;public health medicine (field);Public Health Practice;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Resources;Role;Science;Scientist;Senior Scientist;Sex Behavior;Sexuality;social;social science research;Societies;Staging;statistics;Strategic Planning;Testing;theories;therapy development;Training;transmission process;treatment strategy;trend;Universities;uptake;Work,HIV Center for Clinical Behavioral Studies,43520,ZMH1,Special Emphasis Panel,,,26,1574984,
8609595,P30,MH,5,N,02/03/2014,02/01/2014,01/31/2015,,P30MH043520,,PAR-11-019,5P30MH043520-26,NIMH:472317\,Research Centers,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,10032,,1887216;,"REMIEN, ROBERT H;",,,,Academic Medical Centers;Administrator;Advisory Committees;Affect;Africa;AIDS/HIV problem;Asia;Behavioral;Behavioral Sciences;catalyst;Clinical;Clinical Trials Data Monitoring Committees;Communities;Doctor of Philosophy;Ensure;Environment;Epidemic;experience;forging;Foundations;frontier;Goals;Government;HIV;Hospitals;improved;Individual;innovation;Institutes;Institution;International;Latin America;Leadership;Master of Business Administration;meetings;member;Mental Health;Modeling;Monitor;multidisciplinary;New York;Performance;Policies;Policy Maker;Population;Positioning Attribute;Presbyterian Church;Process;Provider;Psychiatry;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Science;Scientist;Seminal;Source;Strategic Planning;success;System;Vision;Work,Administrative Core,43520,ZMH1,Special Emphasis Panel,8844,,26,,472317
8609596,P30,MH,5,N,02/03/2014,02/01/2014,01/31/2015,,P30MH043520,,PAR-11-019,5P30MH043520-26,NIMH:271874\,Research Centers,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,10032,,6098278;,"MEYER-BAHLBURG, HEINO FL;",,,,Acquired Immunodeficiency Syndrome;Adherence (attribute);AIDS prevention;Anti-Retroviral Agents;Area;Behavioral;Behavioral Sciences;career;Caring;Child;Clinical;Clinical Psychology;Complement;Consultations;cost effective;design;Development;Discipline;Doctor of Philosophy;doctoral student;Ensure;Epidemic;Epidemiology;Exposure to;Family Study;Fostering;frontier;Funding;Funding Agency;Gender;Goals;HIV;innovation;Institution;Interdisciplinary Study;Leadership;member;Mental Health;Mentors;Monitor;multidisciplinary;next generation;Outcome;Peer Review;Pharmaceutical Preparations;Pilot Projects;post-doctoral training;Postdoctoral Fellow;Prevention;Productivity;professor;Psychiatry;Public Health Education;public health medicine (field);Public Health Schools;quality assurance;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Resources;Science;Scientist;Sexuality;Simulate;Staging;Strategic Planning;Training Programs;Translating;Universities;uptake;Work,Development Core,43520,ZMH1,Special Emphasis Panel,8845,,26,,271874
8609597,P30,MH,5,N,02/03/2014,02/01/2014,01/31/2015,,P30MH043520,,PAR-11-019,5P30MH043520-26,NIMH:206058\,Research Centers,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,10033,,1893277;,"BAUMAN, LAURIE J;",,,,Address;Adherence (attribute);AIDS prevention;AIDS/HIV problem;Area;base;Behavior;Behavior Therapy;Behavioral;behavioral/social science;Belief;biobank;Biological;Biological Markers;Biomedical Technology;Caring;Child health care;Clinical;Clinical Psychology;college;Communities;community based participatory research;Community Health;Complement;data management;Development;Development Plans;Doctor of Medicine;Doctor of Philosophy;Effectiveness;Effectiveness of Interventions;effectiveness research;efficacy research;Ensure;Environment;Epidemic;Epidemiology;Ethical Analysis;Ethics;Evaluation;Foundations;Funding;Future;Health;health disparity;Health Policy;HIV;Housing;Immunology;implementation science;improved;Individual;Infection;Information Technology;innovation;Interdisciplinary Study;International;Intervention;Intervention Studies;Intervention Trial;Leadership;Life;Local Microbicides;Measurement;Measures;Medicine;Methods;multidisciplinary;New York City;operation;Oral;Outcome;pandemic disease;Patient Self-Report;Pediatrics;Peer Review;Phase;Policies;Policy Analysis;Policy Maker;Population;prevent;Prevention;Prevention approach;Prevention strategy;Preventive;Process;professor;Prophylactic treatment;Psychiatry;public health medicine (field);Public Health Practice;Recording of previous events;Research;research and development;Research Design;Research Methodology;Research Personnel;Resources;Risk;Risk Behaviors;sample collection;scale up;Science;Senior Scientist;social;social science research;Staging;statistics;Strategic Planning;theories;therapy development;Training;Translations;transmission process;treatment strategy;United States National Institutes of Health;Universities;uptake;Vulnerable Populations;Women's Health;Work;working group,Intervention Science Core,43520,ZMH1,Special Emphasis Panel,8846,,26,,206058
8609598,P30,MH,5,N,02/03/2014,02/01/2014,01/31/2015,,P30MH043520,,PAR-11-019,5P30MH043520-26,NIMH:226744\,Research Centers,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,10017,,6360980;,"LEVIN, BRUCE;",,,,"Address;Adherence (attribute);Adolescent;AIDS prevention;AIDS/HIV problem;antiretroviral therapy;Applications Grants;Area;Argentina;arm;Attention;Award;Behavioral;Behavioral Research;Biological;Biological Assay;Brazil;Caring;Characteristics;Child;Clinical;Clinical Trials Data Monitoring Committees;Clinical Trials Design;cohort;Collection;Communicable Diseases;Communication;Communities;comparative effectiveness;Complex;Consultations;cost effectiveness;Cost Effectiveness Analysis;Country;Data;data integrity;data management;design;Detection;Development;Diagnosis;Discipline;distributed data;Doctor of Philosophy;Drug Formulations;Effectiveness of Interventions;effectiveness research;Emerging Technologies;Ensure;Epidemic;Epidemiology;Equation;experience;Faculty;Family;Female Condoms;Foundations;Future;Gender;Geographic Information Systems;Goals;Guidelines;Health Services;Health Services Research;high risk;high standard;HIV;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;implementation research;implementation science;Incidence;innovation;instrumentation;International;Intervention;intervention effect;Intervention Studies;Intervention Trial;Leadership;Life;Light;Local Microbicides;Marshal;mathematical model;member;men;men who have sex with men;Mentally Ill Persons;Methods;microbicide;Modality;Modeling;Monitor;multi-site trial;Multimedia;New York;New York City;Observational Study;Outcome;Outcome Measure;Performance;Persons;Phase;Pilot Projects;Policies;policy implication;Population;Prevalence;Prevention;Prevention strategy;Process;programs;Prophylactic treatment;quality assurance;Recommendation;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Subjects;Research Technics;Resolution;Resources;Respondent;Risk;Risk Behaviors;Role;Safety;Sampling;scale up;Science;Secure;Serologic tests;Seroprevalences;Simulate;skills;social;Social support;South Africa;Specificity;Staging;Statistical Models;statistics;Subgroup;System;Techniques;Technology;Testing;Thinking, function;tool;transmission process;Treatment outcome;treatment strategy;treatment trial;United States National Institutes of Health;Work;Youth","Statistics, Epidemiology and Data Management",43520,ZMH1,Special Emphasis Panel,8847,,26,,226744
8609599,P30,MH,5,N,02/03/2014,02/01/2014,01/31/2015,,P30MH043520,,PAR-11-019,5P30MH043520-26,NIMH:200487\,Research Centers,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,100122331,,1872610;,"MCKAY, MARY MCKERNAN;",,,,Address;Adherence (attribute);Adoption;Advisory Committees;AIDS prevention;antiretroviral therapy;Area;Attention;base;Behavioral;Behavioral Sciences;biobehavior;Caring;Clinical;college;Communities;Consultations;Country;Development;Doctor of Philosophy;Early identification;Epidemic;Ethicists;Ethics;Evidence based intervention;experience;Funding;Goals;Health;health disparity;Health Policy;HIV;Human Rights;implementation research;implementation science;Institutes;Intervention;Justice;Lead;Leadership;Light;Mental Health;Methods;New York;New York City;Operations Research;Play;Policies;Policy Maker;Policy Research;population based;Poverty;Prevention;professor;Provider;public health ethics;public health medicine (field);Public Health Practice;Public Health Schools;Randomized Controlled Trials;Recording of previous events;Research;Research Ethics;Research Personnel;Research Support;Resources;Role;scale up;Science Policy;Scientist;Services;social disparities;surveillance data;System;Testing;Translating;Translational Research;Translations;trend;Universities;usability;Work,Public Health Practice and Policy Core,43520,ZMH1,Special Emphasis Panel,8848,,26,,200487
8609600,P30,MH,5,N,02/03/2014,02/01/2014,01/31/2015,,P30MH043520,,PAR-11-019,5P30MH043520-26,NIMH:197504\,Research Centers,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,13,167204994,US,NEW YORK STATE PSYCHIATRIC INSTITUTE,NY,10032,,1960623;,"CARBALLO-DIEGUEZ, ALEX;",,,,"Address;Adherence (attribute);Advertising;Affect;AIDS prevention;Anti-Retroviral Agents;Area;Attention;base;Behavioral;Caring;CD-ROM;Cities;Clinical;Code;Collaborations;Communication;Communities;comparative;Computer Assisted;computer human interaction;Computer software;Computers;Confidentiality;cost;cost effective;Data;Data Collection;data management;Data Quality;Data Security;design;Development;digital;Directly Observed Therapy;Disease;Doctor of Philosophy;Educational process of instructing;Electronic Mail;Electronics;Environment;Epidemic;Epidemiology;Ethnography;Evaluation;Event;experience;Family member;Fellowship Program;Funding;gastric secretion substance;Generic Drugs;Goals;HIV;Human;implementation science;improved;Incentives;Information Technology;innovation;interest;Internet;Intervention;intervention effect;Interview;Interviewer;Journals;Knowledge;Learning;Life;literacy;Location;Logic;Los Angeles;Marketing;Mass Media;Measurable;meetings;memory process;men who have sex with men;Mental Health;microchip;Monitor;Multimedia;Neurocognitive;New York;Newspapers;Online Systems;outreach;Participant;Patients;Pharmaceutical Preparations;pill (pharmacologic);Play;Population;Population Density;Positioning Attribute;Preventive Intervention;Printing;Process;processing speed;professor;Prophylactic treatment;Psychiatry;public health medicine (field);Publications;Questionnaires;Radial;ranpirnase;Reaction Time;rectal;Research;Research Personnel;research study;Resources;response;Risk;Role;Rural;Science;Security Measures;Services;Sexual Partners;sharing data;Signal Transduction;Simulate;social;Social Desirability;Social Interaction;Social Network;social norm;Social Sciences;South Africa;Specialist;statistics;Stream;Study Subject;success;symposium;System;Tablets;Technology;Telephone;Testing;Text;theories;Thinking, function;Time;tool;Translational Research;transmission process;Universities;usability;user-friendly;Video Recording;Videoconferences;Videoconferencing;virtual;virtual reality;Voice;web site;Work",New Media Core,43520,ZMH1,Special Emphasis Panel,8849,,26,,197504
8601115,P41,GM,5,N,02/04/2014,01/01/2014,12/31/2014,859,P41GM103622,SCHOOLS OF ARTS AND SCIENCES,PAR-10-225,5P41GM103622-19,NIGMS:1042249\,Research Centers,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,OTHER BASIC SCIENCES,07,042084434,US,ILLINOIS INSTITUTE OF TECHNOLOGY,IL,606163732,"PUBLIC HEALTH RELEVANCE: The Biophysics Collaborative Access Team uses intense X-ray beams from the Advanced Photon Source, Argonne National Laboratory to perform basic biomedical research on non-crystalline biological materials. Results of this research are expected to be relevant to heart disease, arthritis, cancer, and protein misfolding diseases such as Alzheimer's and ALS.",6884030;,"IRVING, THOMAS C;","WU, MARY ANN ",09/30/1997,12/31/2014,Alzheimer's Disease;Archives;Arthritis;Automobile Driving;beamline;Biocompatible Materials;Biomedical Research;Biophysics;Biotechnology;Communities;Controlled Environment;Data;data mining;Data Set;design;Disease;Ensure;experience;Fiber;Future;Gap Junctions;Health;Heart Diseases;Image;Investigation;Laboratories;Light;macromolecule;Malignant Neoplasms;Maps;Modeling;Muscle;Muscle function;Neurodegenerative Disorders;operation;parallel processing;Phase;Photons;protein folding;protein misfolding;Radiation;Research;research study;Resources;RNA Folding;Roentgen Rays;Services;Solutions;Source;System;Techniques;Time;Training Activity;virtual;Visit,The Biophysics Collaborative Access Team,103622,ZRG1,Special Emphasis Panel,,,19,1042249,
8606712,R01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,R01AA012388,,PA-10-067,5R01AA012388-14,NIAAA:676855\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,MENLO PARK,UNITED STATES,,18,009232752,US,SRI INTERNATIONAL,CA,940253493,"PUBLIC HEALTH RELEVANCE: Advanced structural, functional, and electrophysiological neuroimaging of brain connectivity networks will be used to further knowledge about the unique neuroadaptation of the human brain to the injury caused by chronic alcoholism. Knowledge of the extent and specificity of brain dysfunction in alcoholism forms a basis for targeting specific rehabilitation strategies and consideration of new treatment approaches.         ",1873782 (contact);1899194;,"PFEFFERBAUM, ADOLF  (contact);SULLIVAN, EDITH VIONI;","MATOCHIK, JOHN A",08/01/2000,01/31/2016,Age;Alcohol consumption;Alcoholism;Anisotropy;Anterior;Architecture;base;Behavior;Biological Process;blood oxygen level dependent;Brain;Brain Injuries;Brain Pathology;Cerebral hemisphere structure (body structure);Cerebrovascular Circulation;Cerebrum;Chronic;Cognitive;cognitive control;comparison group;conflict resolution;Contingent Negative Variation;Corpus Callosum;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Educational aspects;electrical potential;Electrodes;Electroencephalography;Event-Related Potentials;Eye;Family history of;Fiber;Frequencies (time pattern);frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Human;Image;Impulsivity;indexing;Inferior;Injury;Intelligence;Knowledge;Length;Magnetic Resonance Imaging;Maintenance;Measurable;Measurement;Measures;Medial;men;Methods;Mission;Modality;National Institute on Alcohol Abuse and Alcoholism;neuroadaptation;Neuroanatomy;neuroimaging;Neurons;neuropathology;non-alcoholic;Parietal;Pathology;Physiologic pulse;Prefrontal Cortex;problem drinker;Process;public health relevance;Readiness;rehabilitation strategy;relating to nervous system;Relative (related person);Research;Resolution;Rest;Role;RTN4 gene;Scalp structure;Self Perception;sex;Smoking;sobriety;Specificity;Spin Labels;Structure;System;Testing;Time;Visual;white matter;Woman,NEUROIMAGING OF CONNECTIVITY IN ALCOHOLISM,12388,ZRG1,Special Emphasis Panel,,,14,676855,
8602761,R01,AA,5,N,02/04/2014,02/01/2014,01/31/2015,273,R01AA012518,SCHOOLS OF PUBLIC HEALTH,PA-10-067,5R01AA012518-14,NIAAA:302832\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PROVIDENCE,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,01,001785542,US,BROWN UNIVERSITY,RI,02912,PUBLIC HEALTH RELEVANCE: Brief alcohol interventions reduce drinking and alcohol consequences among at-risk college drinkers. This research aims to strengthen outcomes of these interventions with an e-mail- delivered booster (e-booster) consisting of a series of brief messages designed to correct exaggerated drinking norms. More effective interventions are needed to reduce unnecessary alcohol-related harms among young adults in college.         ,1967448;,"CAREY, KATE B;","WHITE, AARON ",10/01/1999,01/31/2015,Address;Administrator;Adopted;Alcohol abuse;alcohol abuse prevention;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol related consequences;alcohol related problem;alcohol risk reduction;alcohol violation;Alcohols;assault;Attention;Behavior;Behavior Control;binge drinking;brief alcohol intervention;brief intervention;brief motivational intervention;Cessation of life;Cognitive;college;college drinker;college drinking;Communication;communication theory;comparative efficacy;Computers;cost;Data;design;drinking;drinking behavior;effective intervention;Electronic Mail;Feedback;follow-up;Health;Health behavior;Health behavior change;Health Promotion;Heavy Drinking;improved;Individual;Injury;interest;Intervention;Intervention Trial;Mails;Maintenance;Mediating;Mediator of activation protein;Mental Health;motivational enhancement therapy;normative feedback;Outcome;peer;Performance;Phase;Policies;Prevention;Professional counselor;psychologic;public health medicine (field);public health relevance;public policy on alcohol;Randomized;Randomized Controlled Trials;Relative (related person);Research;Risk;Risk Reduction;Safety;Sampling;Science;Series;social;student drinker;student drinking;Students;Technology;Testing;theories;Time;Training;Universities;university student;young adult,Brief alcohol interventions by counselor and computer,12518,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,,14,302832,
8608471,R01,AA,5,N,02/05/2014,12/01/2013,11/30/2014,273,R01AA017924,,PA-07-070,5R01AA017924-06,NIAAA:221894\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BRISBANE QUEENSLAND,AUSTRALIA,,,758590772,AS,QUEENSLAND UNIVERSITY OF TECHNOLOGY,,4001,"PUBLIC HEALTH RELEVANCE: Alcohol use disorders are one of the most serious public health problems worldwide. Neuronal nicotinic acetylcholine receptors (nAChRs) have been shown to contribute to the effects of ethanol. We found that varenicline, a modulator of 1422 nAChRs and recently approved as an aid for smoking cessation, reduces ethanol self-administration and heavy drinking following long-term but not short-term ethanol exposure. We will determine whether long-term ethanol exposure induces changes in the expression of 1422 nAChRs and whether this contributes to the reinforcing effects of ethanol and/or stress-induced relapse. The long-term goal is to design more selective and effective medications for the treatment of alcohol use disorders.         ",8710324;,"BARTLETT, SELENA E.;","EGLI, MARK ",12/01/2009,11/30/2014,addiction;Affect;Agonist;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Animals;Behavioral;Binding (Molecular Function);Biochemical;Brain region;Cell Nucleus;Chimeric Proteins;Chronic;Citrates;Clinical Research;Cocaine;Conotoxin;Cues;Data;design;dopaminergic neuron;drinking;Drosophila acetylcholine receptor alpha-subunit;Drug abuse;drug reinforcement;drug reward;effective therapy;Ethanol;Exposure to;FDA approved;Figs - dietary;footshock induced;Gated Ion Channel;Genes;Goals;Heavy Drinking;Individual;inhibitor/antagonist;Knock-in Mouse;Laboratories;Letters;Ligands;Long-Term Effects;Measures;Mediating;mesolimbic system;methyllycaconitine;Modeling;mRNA Expression;Mus;Neurons;Nicotine;Nicotinic Receptors;Oral;Pharmaceutical Preparations;Play;prevent;protein expression;public health medicine (field);public health relevance;Quantitative Autoradiography;Rattus;receptor;Regulation;Relapse;Research;Role;Self Administration;Smoker;smoking cessation;Societies;Stress;stressor;Techniques;Testing;Therapeutic Agents;Time;Training;Transgenic Organisms;varenicline;Ventral Tegmental Area;Yohimbine,Long-Term Ethanol Exposure and Neuronal Nicotinic Acetylcholine Receptors,17924,NAL,Neurotoxicology and Alcohol Study Section,,,6,221894,
8606720,R01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,R01AA019730,,PA-08-164,5R01AA019730-04,NIAAA:275809\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,LOS ANGELES,UNITED STATES,,33,197170756,US,BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE,CA,90073,"PUBLIC HEALTH RELEVANCE:  Pancreatitis is a serious and sometimes lethal disease of exocrine pancreas, the pathobiology of which is poorly understood, and specific treatments for which do not exist. Alcohol abuse is a major risk factor for pancreatitis;however, the mechanisms by which ethanol predisposes to pancreatitis remain unknown. In this project, we will test the hypothesis that a key mechanism is ethanol-induced damage to lysosomes, resulting in impaired autophagy in pancreas. Lysosome is the key cellular degradative organelle, and autophagy is the main process through which cellular components are digested in lysosomes. We will use mouse models to test our hypothesis. The results can lead to novel therapeutic approaches, targeting impaired lysosomal function in autophagy, to treat or mitigate alcoholic pancreatitis in humans. Further, similar mechanisms involving ethanol-induced lysosomal damage may mediate ethanol's toxicity to other organs.            ",8675343 (contact);9844633;,"GUKOVSKY, ILYA  (contact);MARENINOVA, OLGA A;","MURRAY, GARY ",02/01/2011,01/31/2016,Acinar Cell;Acute;acute pancreatitis;Affect;Alcohol abuse;alcohol effect;Alcoholic Pancreatitis;Alcohols;analog;Autophagocytosis;Autophagosome;base;Cathepsins;Cholecystokinin;Data;Disease;Dose;Endotoxemia;Ethanol;Ethanol toxicity;Event;Exocrine pancreas;Experimental Models;feeding;Functional disorder;Genetic;Goals;Golgi Apparatus;Human;Hydrolase;Impairment;In Vitro;in vivo;insight;Knock-out;LAMP-2;late endosome;Lead;Life;Lysosomes;Mediating;Mediator of activation protein;Membrane Proteins;Mitochondria;Modeling;mouse model;Mus;new therapeutic target;non-alcoholic;novel;novel therapeutic intervention;Organ;Organelles;overexpression;Pancreas;Pancreatitis;Pathogenesis;Pathologic;Pathway interactions;Process;Proteins;public health relevance;Rattus;Resolution;response;Risk Factors;Rodent;Role;Sincalide;Stress;stressor;Testing;trafficking;Trypsin;Trypsinogen;Vacuole,"Lysosomal Damage, Impaired Autophagy, and Alcoholic Pancreatitis",19730,CIMG,"Clinical, Integrative and Molecular Gastroenterology Study Section",,,4,275809,
8599740,R01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,R01AA020252,SCHOOLS OF MEDICINE,PA-10-100,5R01AA020252-03,NIAAA:529690\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,SEATTLE,UNITED STATES,PSYCHIATRY,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472," This research uses innovative methodologies to explore the extent to which a standard PTSD or substance use therapy can be used to treat comorbid PTSD and alcohol abuse/dependence. Research findings should help us understand more about mechanisms of change during PTSD and substance use treatment. It is also hoped that the results will offer new treatment options for those with comorbid conditions, will help us improve existing treatments, and increase our ability to determine who may best respond to a specific treatment approach.                ",7690519 (contact);8635210;,"KAYSEN, DEBRA L (contact);SIMPSON, TRACY L.;","ROACH, DEIDRA ",02/10/2012,01/31/2017,Address;Affect;Aftercare;Alcohol abuse;Alcohol consumption;alcohol craving;Alcohol dependence;Alcohol or Other Drugs use;alcohol use disorder;Alcohols;clinical practice;Cognitive;Combined Modality Therapy;Communities;Comorbidity;Complex;coping;craving;Cues;Data;Dependence;Disease;disorder later incidence prevention;distress tolerance;drinking;effective therapy;Funding;improved;Individual;innovation;interactive therapy;Mediating;Mediator of activation protein;meetings;Methodology;Modeling;Monitor;Neurobehavioral Manifestations;Outcome;Participant;Patients;Phase;Population;Post-Traumatic Stress Disorders;Process;Randomized;Recruitment Activity;reduced substance use;Relapse;Relative (related person);Research;response;Self Efficacy;Self Medication;Severities;social;Specific qualifier value;Symptoms;System;Telephone;Testing;theories;Trauma;Treatment outcome;treatment response;Voice;Waiting Lists;Work,SEQUENCE OF SYMPTOM CHANGE DURING AUD OR PTSD TREATMENT FOR COMORBID PTSD/AUD,20252,AA,Biomedical Research Review Subcommittee,,,3,529690,
8601685,R01,AA,5,N,02/01/2014,02/01/2014,01/31/2015,273,R01AA020331,SCHOOLS OF MEDICINE,PA-11-016,5R01AA020331-03,NIAAA:699115\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PHILADELPHIA,UNITED STATES,BIOSTATISTICS &OTHER MATH SCI,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"PUBLIC HEALTH RELEVANCE: To the best of our knowledge, there have been no prior experimental trials of vacant lot stabilization and substance abuse-related outcomes, both alcohol and drug related. By remediating vacant lots across Philadelphia and then studying the effects of these remediations using a randomized trial, the proposed project's findings will contribute to municipal and national efforts to implement effective environmental modifications that can address public substance abuse behaviors and impact community health and well- being. The proposed study will produce scientific findings on the contribution of neighborhood environment to health, with a specific focus on public occurrence of alcohol and drug consumption and related illegal activities.         ",1974739;,"BRANAS, CHARLES C.;","RUFFIN, BEVERLY ",02/10/2012,01/31/2016,addiction;Address;Advocate;Aftercare;Alcohol abuse;Alcohol consumption;Alcohol or Other Drugs use;Alcoholic Intoxication;Alcohols;Area;arm;base;Behavior;behavior change;Caring;Cities;Communities;Community Health;Consumption;cost;cost effectiveness;Crime;design;drinking;Drug abuse;Drug usage;Economics;Effectiveness;Environment;Epidemiology;evidence base;Health;high risk;Housing;Illicit Drugs;implementation trial;Individual;innovation;Intervention;Left;Life Style;Measures;member;Mental Health;Modification;Movement;Neighborhoods;Observational Study;Out-Migrations;Outcome;Overdose;Patient Self-Report;Pennsylvania;Personal Behavior;Personal Satisfaction;Pharmaceutical Preparations;Philadelphia;physical conditioning;Plants;Poaceae;Prevention;Prevention strategy;Process;programs;Property;Psyche structure;public health medicine (field);public health relevance;randomized trial;Reliance;remediation;Research;research study;response;Risk;Risk Behaviors;Safety;Societies;Source;Substance abuse problem;substance abuse related behavior;System;Testing;theories;three-arm study;trafficking;Trees;Work,A randomized trial of urban vacant lot stabilization and substance abuse outcomes,20331,CLHP,Community-Level Health Promotion Study Section,,,3,699115,
8606721,R01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,R01AA020822,HOSPITALS,PA-08-164,5R01AA020822-03,NIAAA:319950\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,HOUSTON,UNITED STATES,BIOLOGY,09,800772139,US,UT MD ANDERSON CANCER CTR,TX,770304009, The development of new treatments for alcohol related pancreatic disease had been hindered by the lack of physiologically relevant animal models. We have developed for the first time an animal model with a modified genetic background that develops alcohol dependent chronic pancreatitis without the need for additional injurious treatments. This new model will provide an opportunity to discover important new details about the role of alcohol in pancreatic disease.          ,1877254;,"LOGSDON, CRAIG D;","GAO, PETER ",02/05/2012,01/31/2017,Acinar Cell;Acute;acute pancreatitis;Affect;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcoholic chronic pancreatitis;Alcohols;Animal Disease Models;Animal Feed;Animal Model;Animals;Apoptosis;Apoptotic;Autophagocytosis;Biological Factors;Breeding;Caerulein;CCAAT-Enhancer-Binding Protein-alpha;Cell Death;Cells;Cellular Stress;Cholecystokinin;Chronic;chronic pancreatitis;Data;Development;Diet;Disease;Down-Regulation;Ethanol;factor C;feeding;Genetic;Goals;Heterozygote;Human;Inflammation;Inflammatory Response;Inherited;injured;Injury;Lead;Metallothionein;Modeling;mouse model;Mus;mutant;Mutation;Necrosis;novel;Pancreas;Pancreatic Diseases;Pancreatitis;Pathology;Play;Predisposition;Research Personnel;response;Rodent;Role;Severity of illness;Stress;Supplementation;Testing;Time;transcription factor;Translations;Trypsin;Trypsinogen,Alcohol Induced Chronic Pancreatitis,20822,CIMG,"Clinical, Integrative and Molecular Gastroenterology Study Section",,,3,319950,
8606726,R01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,R01AA021162,SCHOOLS OF MEDICINE,PA-11-016,5R01AA021162-02,NIAAA:401557\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,LA JOLLA,UNITED STATES,PSYCHIATRY,52,804355790,US,UNIVERSITY OF CALIFORNIA SAN DIEGO,CA,920930934,"PUBLIC HEALTH RELEVANCE: Heavy drinking and associated problems are highly prevalent in university settings. Recent research has identified key elements of programs aimed at preventing alcohol-related morbidity and mortality, but such programs, while effective, have only had a modest impact. This project proposes to enhance the effectiveness of prevention programs by recognizing the higher vulnerability toward alcohol-related problems in individuals with low levels of response (or low sensitivity) to alcohol, and tailoring the usual prevention protocol to address the needs of these students with elevated risks for alcohol problems.            ",1902082;,"SCHUCKIT, MARC A;","WHITE, AARON ",02/01/2013,01/31/2015,Address;Administrator;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol related problem;alcohol response;alcohol sensitivity;Alcohols;Attitude;base;Behavior;Belief;Characteristics;college;college drinking;comparison group;cost;Data;Demography;design;drinking;Educational process of instructing;Effectiveness;Elements;Emotional;Equilibrium;expectation;Exposure to;Focus Groups;follow-up;Future;group intervention;Heavy Drinking;High Prevalence;improved;Impulsivity;Individual;Institutes;interest;Internet;Intervention;Knowledge;Link;Manufactured Visual Aid;Measures;Mediating;Mediator of activation protein;member;Methods;Modeling;Moods;Morbidity - disease rate;Mortality Vital Statistics;National Institute on Alcohol Abuse and Alcoholism;novel;novel strategies;Outcome;Pattern;peer;Phenotype;Pilot Projects;Population;Predisposition;prevent;Prevention;Prevention approach;Prevention program;Prevention Protocols;Procedures;programs;Protocols documentation;public health relevance;Questionnaires;Randomized;Recording of previous events;Recruitment Activity;Relative (related person);Research;response;Risk;Risk Factors;Stress;Structure;student drinking;Students;Study Subject;Surveys;Techniques;Testing;Time;Universities;Videotape;Work,PREVENTION APPROACH TO COLLEGE HEAVY DRINKING BASED ON A LOW RESPONSE TO ALCOHOL,21162,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,,2,401557,
8603218,R01,AI,5,N,02/04/2014,01/01/2014,12/31/2014,855,R01AI052116,SCHOOLS OF MEDICINE,PA-10-067,5R01AI052116-12,NIAID:346514\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,PATHOLOGY,12,094878337,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"PUBLIC HEALTH RELEVANCE: Many activities in the immune system are controlled as a result the movement and interactions of T cells within organs. To seek how to improve T cell functions, we are seeking to understand the basis by which these cells 'scan'our tissues and recognize infections or respond to vaccines. Specifically, we will determine the role of three families of proteins that variously apply tension to the membrane and affect the dynamics of cell membranes as they engage with the tissues to be scanned.                ",1929409;,"KRUMMEL, MATTHEW F;","LAPHAM, CHERYL K.",09/15/2002,12/31/2017,Actins;Adherence (attribute);Affect;antigen processing;Antigen-Presenting Cells;base;Behavior;Belief;cell cortex;Cell membrane;cell motility;Cell physiology;Cell Polarity;Cell surface;cell type;Cells;Cellular Membrane;Cytoskeleton;Data;depolymerization;Diffusion;Disease;Environment;Exposure to;Extracellular Matrix;Genetic;glycosylation;Goals;Grant;Habitats;Homeostasis;Hyaluronic Acid;Immune;Immune system;Immunity;immunological synapse;improved;In Situ;In Vitro;in vivo;Individual;Infection;interstitial;Knock-out;knockout animal;Lead;Link;Membrane;Membrane Biology;migration;Motor;Movement;Mucins;Myosin ATPase;Nonmuscle Myosin Type IIA;Organ;Pathway interactions;Pattern;Process;protein aggregation;Protein Family;Protein Isoforms;Proteins;public health relevance;Regulation;Research Personnel;response;Role;Scanning;Signal Transduction;Surveys;Synapses;synaptogenesis;System;T-Cell Receptor;T-Lymphocyte;Tissues;tumor;Vaccination;Vaccines;Variant;Walking;Work,Cytoskeletal Regulation of T cell Motility and Synaptic Signaling,52116,CMIA,Cellular and Molecular Immunology - A Study Section,,,12,346514,
8604350,R01,AI,5,N,02/04/2014,02/01/2014,01/31/2015,855,R01AI054544,SCHOOLS OF MEDICINE,PA-07-070,5R01AI054544-11,NIAID:329781\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WORCESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,603847393,US,UNIV OF MASSACHUSETTS MED SCH WORCESTER,MA,016550002,"PUBLIC HEALTH RELEVANCE: Meningococcal meningitis and sepsis is a major health problem worldwide. It mainly affects children and young adults and is a significant cause of morbidity and mortality. Although a good vaccine exists against several meningococcal serogroups, there is no effective vaccine against serogroup B disease. The emergence of disease caused by strains that lack a capsule following vaccination campaigns using capsular polysaccharide-based vaccines is of concern. Complement forms an important arm of host defenses against the meningococcus. The studies proposed in this application will help us better understand how this pathogen escapes killing by complement and will ultimately aid in the development of better vaccines against meningococcal meningitis.         ",6908476;,"RAM, SANJAY;","TAYLOR, CHRISTOPHER E.,",04/01/2003,01/31/2015,Address;Affect;Animal Model;Antibiotics;Antibodies;Antibody Specificity;Antigens;arm;Bacteria;bactericide;base;Binding (Molecular Function);Binding Proteins;blocking factor;Blood;Blood Circulation;capsule (pharmacologic);Cerebrospinal Fluid;Child;Classical Complement Pathway;Clinical;Complement;Complement 4b;Complement Activation;complement deficiency;Complement Factor B;Complement Factor H;Complement Membrane Attack Complex;complement pathway;complement system;Complex;Defense Mechanisms;Deposition;design;Development;Disease;disorder prevention;Encapsulated;Epidemiology;Equilibrium;Fc domain;Feedback;Funding;Genome;Goals;Gold;Health;Host Defense;Human;Hybrids;IgG1;Immune;Immunization;Immunoglobulin G;Immunoglobulin M;improved;Inactivated Vaccines;Infection;inhibitor/antagonist;insight;Invaded;Killings;Knowledge;Lead;Ligands;lipooligosaccharide;Lipoproteins;Mediating;Membrane;Membrane Proteins;Meningococcal Infections;Meningococcal meningitis;Microbe;Modeling;Molecular;Morbidity - disease rate;Mortality Vital Statistics;Mucous Membrane;Nasopharynx;Neisseria;Neisseria meningitidis;novel;Organism;Oryctolagus cuniculus;Outcome;pathogen;Pathogenesis;Pathway interactions;Persons;phosphoethanolamine;polyanion;Polysaccharides;Properdin;Protein Binding;Proteins;public health relevance;Recurrence;Regulation;Resistance;Role;Sepsis;Serum;Site;Specificity;Surface;System;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;Vaccines;Virulence;young adult,Complement Activation on Neisseria meningitidis,54544,HIBP,Host Interactions with Bacterial Pathogens Study Section,,,11,329781,
8593221,R01,AI,5,N,02/07/2014,12/01/2013,11/30/2014,855,R01AI057555,HOSPITALS,PA-07-070,5R01AI057555-11,NIAID:381150\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HOUSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,09,800772139,US,UT MD ANDERSON CANCER CTR,TX,770304009,"PUBLIC HEALTH RELEVANCE: Toll-like receptors detect various microbial components and signal host cells to produce various inflammatory mediators that combat infection, however, prolonged or exacerbated production of inflammatory mediators can cause chronic or acute inflammatory diseases. The goal of this research project is to understand the molecular mechanism by which toll-like receptors transduce signals leading to the induction of host immune factors, which is important for rational design of more effective anti-inflammatory therapies.         ",1882175;,"SUN, SHAO-CONG;","PALKER, THOMAS J.",03/01/2004,11/30/2014,activating transcription factor;Acute;Affinity Chromatography;Amino Acids;Anti-inflammatory;Anti-Inflammatory Agents;base;Binding (Molecular Function);Biological Response Modifiers;Cells;Chronic;combat;Complex;cytokine;Data;design;Disease;Extracellular Signal Regulated Kinases;Foundations;Funding;Genes;Genetic;Goals;Health;Immune;Infection;Inflammation Mediators;Inflammatory;inhibitor/antagonist;innovation;Kinetics;Knockout Mice;Knowledge;Laboratories;Lead;Ligands;Link;MAP2K1 gene;Mass Spectrum Analysis;Mediating;MEKs;Microbe;microbial;Mitogen-Activated Protein Kinases;Molecular;N-terminal;Natural Immunity;novel;Pathway interactions;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;prevent;Production;Protein Family;Protein Isoforms;Receptor Signaling;Regulation;Research Project Grants;Role;Seminal;Septic Shock;Sequence Homologs;Signal Pathway;Signal Transduction;Solid;TLR3 gene;TLR4 gene;Toll-Like Receptor Pathway;Toll-like receptors;ubiquitin ligase;ubiquitin-protein ligase;Work,The IKK/Tpl2 axis of TLR signaling,57555,CSRS,Cellular Signaling and Regulatory Systems Study Section,,,11,381150,
8605495,R01,AI,5,N,02/05/2014,02/01/2014,01/31/2015,855,R01AI060921,SCHOOLS OF VETERINARY MEDICINE,PA-07-070,5R01AI060921-10,NIAID:356400\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,PUBLIC HEALTH RELEVANCE: Calcium is a multifunctional second messenger that regulates nearly every aspect of lymphocyte differentiation and function and thereby the immune response. The primary objective of these studies is to understand novel mechanisms by which calcium entry into lymphocytes is regulated. Results from these studies will identify targets and strategies both positive and negative manipulation of the immune response to ameliorate immunodeficiency diseases and/or to suppress development of autoimmune and inflammatory disease.         ,1895569;,"FREEDMAN, BRUCE D;","FERGUSON, STACY E.",06/01/2004,01/31/2015,Adaptor Signaling Protein;Antibodies;Antigen Receptors;Autoimmune Process;B-Lymphocytes;base;Binding (Molecular Function);BLNK gene;Calcium;Calcium Signaling;Cations;Cell membrane;Clinic;Coupling;Cytoplasm;Cytoskeleton;Data;Development;Disease;Distal;Endoplasmic Reticulum;Generations;Immune;Immune response;Immune System Diseases;Immunologic Deficiency Syndromes;Inflammatory;inhibitor/antagonist;insight;Link;Lipase;Lymphocyte;Lymphocyte Function;Mediating;Membrane;Microinjections;Molecular;novel;Pathway interactions;Phosphorylation;Phosphotransferases;Play;Point Mutation;Protein Tyrosine Kinase;Proteins;public health relevance;receptor;Regulation;Role;second messenger;Second Messenger Systems;sensor;Signal Transduction;STIM1 gene;Structure;Suggestion;T-Cell Activation;Testing;TRPC3 ion channel;Tyrosine;Work,Novel Mechanisms of Calcium Signaling in B lymphocytes,60921,CMIB,Cellular and Molecular Immunology - B Study Section,,,10,356400,
8591371,R01,AI,5,N,02/07/2014,12/01/2013,11/30/2014,855,R01AI087164,,PA-07-070,5R01AI087164-05,NIAID:315414\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN DIEGO,UNITED STATES,,52,933863508,US,VETERANS MEDICAL RESEARCH FDN/SAN DIEGO,CA,92161,PUBLIC HEALTH RELEVANCE: Many HIV-infected patients fail to recover their immune system when placed on drug therapy. This research will identify patient genes that contribute to immune recovery and represent new targets for drugs that can be used to increase immune recovery. This proposal will also identify which drugs an HIV-infected patient should be treated with in order to maximize the extent of their immune recovery.            ,1871837;,"RICHMAN, DOUGLAS D;","LIVNAT, DANIELLA ",12/15/2009,11/30/2014,3'Untranslated Regions;Acquired Immunodeficiency Syndrome;Acute;Address;Affect;Anti-Retroviral Agents;Apoptosis;base;Biological Markers;Biological Process;Candidate Disease Gene;Categories;CD4 Positive T Lymphocytes;Cell Count;Cells;Cessation of life;Clinical;clinical risk;cohort;cytokine;design;Disease;disease diagnosis;Disease Outcome;Drug Targeting;Event;Exhibits;Future;Gene Expression;Gene Expression Profiling;Gene Targeting;Genes;Genetic;Goals;Health;HIV;Immune;Immune system;Immune Targeting;In Vitro;in vitro Assay;Incidence;Individual;Infection;innovation;Maps;Messenger RNA;Microarray Analysis;MicroRNAs;mRNA Expression;mRNA Transcript Degradation;non-nucleoside reverse transcriptase inhibitors;novel therapeutics;Ontology;Outcome;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacotherapy;Play;Preparation;prevent;programs;Protease Inhibitor;public health relevance;Recovery;Regimen;Regulation;Relative Risks;Reporter;Research;response;RNA;Role;Sampling;Site;Small Interfering RNA;T-Cell Proliferation;Tissue-Specific Gene Expression;Tissues;tool;Transcript;Treatment Protocols;Viral Load result;Virus Replication,Gene expression biomarkers of immune recovery in HIV infected patients,87164,AIP,AIDS Immunology and Pathogenesis Study Section,,,5,315414,
8602809,R01,AI,5,N,02/07/2014,01/01/2014,12/31/2014,855,R01AI087528,SCHOOLS OF ARTS AND SCIENCES,PA-07-070,5R01AI087528-05,NIAID:382388\,Research Projects,2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,BIOLOGY,52,804355790,US,UNIVERSITY OF CALIFORNIA SAN DIEGO,CA,920930934,"PUBLIC HEALTH RELEVANCE: Microsporidia are responsible for a wide variety of infections, including severe intestinal infections in AIDS patients. However, the molecular mechanisms used by microsporidia to infect host cells, and the host innate immune response to these infections, are poorly understood. This proposal employs a natural nematode host model for microsporidia pathogenesis in the intestine that has potential applicability to understanding the pathogenesis of microsporidian infections in the human intestine.            ",1924601;,"TROEMEL, EMILY R;","DUNCAN, RORY A.",01/15/2010,12/31/2014,"Acquired Immunodeficiency Syndrome;Address;Animal Model;Animals;Binding (Molecular Function);Biochemical;Biological Process;Caenorhabditis;Caenorhabditis elegans;Cell physiology;Cells;cellular microvillus;Cellular Structures;Cessation of life;Characteristics;Child;Complement;Cues;defense response;Detection;Development;Diarrhea;Disease;Epidemic;Epithelial Cells;Fingers;fungus;Genes;Genetic;Genome;Genomics;Goals;Human;Image;Imaging Device;Immune;Immune response;in vivo;Infection;Infection Control;innovation;insight;Internet;Intestines;Invaded;Label;Libraries;Life;Medical;Microsporidia (protozoa);Mission;Modeling;Molecular;molecular imaging;Names;Natural regeneration;Natural Resistance;Nematoda;novel;Organ;Parasites;Paris, France;pathogen;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Plague;Predisposition;Property;Proteins;public health relevance;Reproduction spores;Research;Resistance;Resistance to infection;RNA Interference;Signal Pathway;Staging;Structure;Subcellular structure;System;Techniques;Testing;Transgenic Organisms;Transplant Recipients;Variant",A natural host model for microsporidia pathogenesis in the intestine,87528,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,,5,382388,
8608939,R01,AR,5,N,02/01/2014,02/01/2014,01/31/2015,846,R01AR059397,SCHOOLS OF MEDICINE,PA-07-070,5R01AR059397-05,NIAMS:383153\,Research Projects,2014,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,HERSHEY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,129348186,US,PENNSYLVANIA STATE UNIVERSITY,PA,170330850,"PUBLIC HEALTH RELEVANCE: Static (i.e., weight lifting) exercise is well known to stimulate thin fiber sensory nerves, which in turn activate the sympathetic nervous system, an effect which in turn causes vasoconstriction in the heart, kidneys and the skeletal muscles. In hearts whose coronary arteries are narrowed by disease, this vasoconstriction can cause chest pain and fatal arrhythmias. Likewise, in muscles, whose arteries are narrowed by disease, exercise can cause excessive stimulation of the sensory nerves that reflexively activate the sympathetic nervous system muscle pain (i.e., claudication).         ",1890920;1862973 (contact);2404476;,"ELMSLIE, KEITH S;KAUFMAN, MARC PETER (contact);RUIZ-VELASCO, VICTOR;","BOYCE, AMANDA T.",04/01/2010,01/31/2015,"Action Potentials;Adult;afferent nerve;Afferent Neurons;Agonist;arm;Arrhythmia;Arteries;artery occlusion;Attention;Blood Circulation;Blood flow;Blood Pressure;Bradykinin;Bradykinin Receptor;Cardiac Output;Cardiovascular system;Cells;Chest Pain;claudication;Contracts;Coronary artery;density;Disease;Electrophysiology (science);Enkephalin, Ala(2)-MePhe(4)-Gly(5)-;Environmental air flow;Esthesia;Exercise;femoral artery;Fiber;ganglion cell;Goals;Green Fluorescent Proteins;Heart;Heart Rate;Hindlimb;In Vitro;in vivo;insight;Ion Channel;Kidney;Label;Limb structure;Mechanics;Mediating;Membrane;Metabolic;Muscle;Muscle Fibers;Myalgia;Names;neuromechanism;Neurons;Opioid;Opioid Receptor;Oxygen;Pain;patch clamp;Patch-Clamp Techniques;Peptides;Peripheral;Peripheral Vascular Diseases;Physiological;Play;pressure;Promoter Regions (Genetics);Property;Prostaglandins;public health relevance;Rattus;receptive field;receptor;Reflex action;research study;Resistance;Role;Sensory;Signal Transduction;Skeletal muscle structure;Spinal Ganglia;Stimulus;Sympathetic Nervous System;System;Testing;Tetrodotoxin;Translating;Triceps brachii muscle structure;Vascular blood supply;Vascular constriction (function);voltage;Weight Lifting",Excitability of Afferents Evoking the Exercise Pressor Reflex,59397,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,,5,383153,
8627122,R01,CA,5,N,02/05/2014,02/01/2014,01/31/2015,393,R01CA075056,,PA-07-070,5R01CA075056-15,NCI:504168\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,09,041332172,US,PACIFIC NORTHWEST RESEARCH INSTITUTE,WA,98122,"PUBLIC HEALTH RELEVANCE: Testicular cancer is one of the most common malignancies affecting young men. Although the genetic control of susceptibility is unusually strong, little progress has been made finding these genes that could be used define the mechanisms of susceptibility and that could serve as diagnostic markers or as treatment targets. We discovered three TGCT susceptibility genes, two of which suggest that control of mRNA translation has dramatic effects on susceptibility. In this application, we propose studies to test hypotheses about mechanisms by which changes in translation control modulate TGCT susceptibility. We also discovered, and propose to characterize spontaneous TGCT metastases in several of our mouse models.            ",1858512;,"NADEAU, JOSEPH H.;","SHARMAN, ANU ",06/01/1998,01/31/2015,129/Sv Mouse;3'Untranslated Regions;Accounting;Address;Affect;Apolipoproteins B;Apoptosis;base;Bilateral;Biological Assay;Biology;Cell Culture Techniques;Cell Lineage;cell motility;Cellular biology;Characteristics;Child;Childhood Testicular Germ Cell Tumor;Complex;congenic;Development;Diagnostic;Disease susceptibility;early childhood;Enterochromaffin Cells;Environmental Risk Factor;Family;Fetal development of the mammalian embryo or fetus;Frequencies (time pattern);Funding;Future;gene interaction;Gene Mutation;Generations;Genes;Genetic;Genetic Epistasis;Genetic Risk;Genetic Translation;genetic variant;Goals;Heterozygote;Human;In Vitro;in vivo;Inbred Strain;Incidence;Infertility;Location;lymph nodes;male;Malignant Childhood Neoplasm;Malignant neoplasm of testis;Malignant Neoplasms;Mammals;Messenger RNA;MicroRNAs;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nature;Neoplasm Metastasis;Nephroblastoma;novel;Paper;Parents;Pathway interactions;Peptide Initiation Factors;Population Attributable Risks;Predisposition;Process;Process Measure;Protein Isoforms;Proteins;public health relevance;Publishing;Reporting;research study;Resistance;Risk Factors;RNA Editing;Role;Signal Transduction;Site;Son;Specificity;Steel;Stem Cell Factor;Stem cells;Structure of primordial sex cell;Susceptibility Gene;Testicular Germ Cell Tumor;Testing;Therapeutic Intervention;Transcript;Translations;tumor;Tumor Stem Cells;Tumor Suppressor Proteins;tumorigenesis;Urogenital Abnormalities;Validation;Variant;Wild Type Mouse;Y Chromosome;young man,Genetic control of susceptibility of testicular cancer,75056,CG,Cancer Genetics Study Section,,,15,504168,
8610888,R01,CA,5,N,02/07/2014,02/01/2014,01/31/2015,393,R01CA091791,SCHOOLS OF MEDICINE,PA-10-290,5R01CA091791-12,NCI:256093\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,PHARMACOLOGY,33,092530369,US,UNIVERSITY OF CALIFORNIA LOS ANGELES,CA,900952000,"PUBLIC HEALTH RELEVANCE: This project studies the effects of oxidative stress signaling on the reactivation process of KSHV utilizing cell biology and mathematic approaches. The study will define the molecular mechanism by which the KSHV senses cell stress signals to decide the switch between latency and lytic replication. It not only addresses a fundamental biological question, but also can facilitate the development of new preventive and/or therapeutic approaches.            ",1859203;,"SUN, REN;","READ-CONNOLE, ELIZABETH LEE",04/01/2001,01/31/2018,Acetylcysteine;Acquired Immunodeficiency Syndrome;Address;Antioxidants;Biological;biological adaptation to stress;Biological Models;biological systems;Cell Culture Techniques;Cell Proliferation;Cells;Cellular biology;Cellular Stress;Chemoprevention;chemotherapy;clinical application;Data;Development;Doxorubicin;effective therapy;Effectiveness;Epithelial Cells;Equilibrium;Flow Cytometry;Foundations;Future;gammaherpesvirus;Human;Human Herpesvirus 4;human herpesvirus 8;Impotence;in vivo;Infection;latent infection;Life Cycle Stages;Lung;Lymphoma;lytic gene expression;lytic replication;Malignant Neoplasms;mathematical model;Mathematics;Measures;Mediating;Modality;Modeling;Molecular;mouse model;Murine herpesvirus 68;Mus;Nature;neoplastic cell;new technology;novel;novel strategies;novel therapeutic intervention;Oral;Output;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Pathway;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphorylation;Physiological;Play;prevent;Prevention;Prevention strategy;Preventive;primary effusion lymphoma;Process;Production;Proteins;public health relevance;reactivation from latency;Reactive Oxygen Species;Regulation;response;Risk;Role;Signal Transduction;Signaling Molecule;Sirolimus;Solid;Systems Biology;Techniques;Therapeutic;Translational Research;transmission process;Transplantation;Treatment Efficacy;tumor;tumor growth;tumor progression;Viral;Virion;Virus;virus host interaction;Western Blotting;Xeno;Xenograft procedure,Reactivation of Kaposi's Sarcoma-Associated Herpesvirus,91791,ZRG1,Special Emphasis Panel,,,12,256093,
8586232,R01,CA,5,N,02/04/2014,02/05/2014,11/30/2014,393,R01CA098803,,PA-07-070,5R01CA098803-10,NCI:1762716\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,TAMPA,UNITED STATES,,15,139301956,US,H. LEE MOFFITT CANCER CTR &RES INST,FL,336129497,"PUBLIC HEALTH RELEVANCE: Little is known about the progression of genital HPV infections to disease in men. Just as these data were critical to the successful development and implementation of HPV vaccines for women, they are also critical to the development of vaccines targeting men. The overall goal of this Natural History of HPV Infection in Men (HIM) Study competitive renewal application is to define the natural history of HPV-related genital disease in men. The central hypothesis is that genital disease incidence in men is significantly associated with age and HPV antibody status, and influenced by HPV type and infection duration. To our knowledge this proposed research is the first to prospectively assess HPV infection progression to genital disease in men. As these lesions may be important reservoirs of infection for transmission, they have significance for the disease status of the male as well as his sexual partner(s). In addition to the significant scientific contribution this study will make, the HIM Study has established a data and biological specimen repository with which to test future and ancillary scientific hypotheses related to HPV infection and disease in men.         ",1872587;,"GIULIANO, ANNA R.;","STARKS, VAURICE ",01/01/2003,11/30/2014,Address;Age;Anogenital venereal warts;Antibodies;Antibody Formation;Behavioral;Biological;Biopsy;Biopsy Specimen;Brazil;Cancerous;Case Series;Categories;Clinical;clinical practice;Cohort Studies;condoms;condyloma;Country;Data;design;Detection;Development;Disease;Disease Progression;disorder risk;DNA;Effectiveness;Evaluation;experience;follow-up;Future;Genital system;Goals;Histologic;HPV capsid antibodies;Human Herpesvirus 2;Human Papilloma Virus Vaccine;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 6;Humoral Immunities;Immune;improved;Incidence;Infection;innovation;Knowledge;Lead;Lesion;male;Male Circumcision;Malignant neoplasm of penis;Measures;men;Methods;molecular marker;Molecular Virology;Morbidity - disease rate;Mortality Vital Statistics;Natural History;older men;Participant;Pathologic;Penile Intraepithelial Neoplasia;physical state;Population;prospective;public health relevance;Publishing;repository;Research;Research Infrastructure;Research Personnel;Risk;Risk Factors;Role;Sex Behavior;Sexual Partners;Sexually Transmitted Diseases;Specimen;Testing;Time;transmission process;vaccine development;Vaccines;Variant;Viral;Viral Load result;Woman,Natural History of HPV Infection in Men: The HIM Study,98803,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",,,10,1762716,
8598855,R01,CA,5,N,02/03/2014,01/01/2014,12/31/2014,394,R01CA098966,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01CA098966-09,NCI:241350\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,SOCIAL SCIENCES,11,077758407,US,CASE WESTERN RESERVE UNIVERSITY,OH,441067015,"PUBLIC HEALTH RELEVANCE: The proposed study has direct relevance to public health. Our goal is to improve older patients'advocacy skills and their ability to communicate with their physicians regarding cancer prevention and general medical care. We expect that the confidence and initiative they will acquire as a result of our intervention will result in improvements in the preventive care they will receive. Having well informed patients, who also respect physician expertise, participating in medical encounters, will improve both efficiency and effectiveness of office visits for the aged. Prevention and early detection of cancer have been recognized as important public health strategies for reducing the burden of chronic and life threatening illnesses, both on society and on individuals. Our focus on communication skills training among low health literacy and minority elders should also contribute to minimizing health disparities.         ",1889048;,"KAHANA, EVA;","PATRICK, HEATHER A",12/01/2002,12/31/2015,Active Learning;Address;Adopted;Advocacy;Age;aged;Aging;Appointment;Area;Attention;base;cancer care;Cancer Control;cancer prevention;Caring;Characteristics;Chronic;Clinical;Communication;Communities;community organizations;Competence;Complement;Control Groups;cost effective;Data;Data Analyses;Decision Aid;Decision Making;design;diaries;Disadvantaged;Educational aspects;Educational Intervention;Effectiveness;Elderly;empowerment;ethnic minority population;Evaluation;follow-up;forging;Foundations;Funding;Future;Goals;group intervention;Guidelines;Health;Health Communication;health disparity;health literacy;Health Promotion;Healthcare;improved;indexing;Individual;insight;Intervention;intervention effect;intervention program;Intervention Studies;Interview;Judgment;Lead;Learning;Life;Low income;Medical;Medicare claim;Methods;Minority;Mission;Modality;Modeling;multilevel analysis;National Cancer Institute;novel;nutrition;Office Visits;older patient;Outcome;Participant;Patient advocacy;Patient Education;patient oriented;Patient Outcomes Assessments;Patient Participation;Patients;Perception;Physicians;Play;Population Study;post intervention;Prevention;Preventive;Primary Care Physician;Process;programs;public health medicine (field);public health relevance;Randomized;Randomized Controlled Trials;Readiness;Recommendation;rehearsal;Relative (related person);Reporting;Research;Research Design;Resources;Risk;Role;satisfaction;screening;Screening for cancer;skills;skills training;social;social cognitive theory;Societies;Telephone;Testing;Time;Training;Training Programs;uptake;user-friendly;Visit,Health Care Partners in Cancer Prevention and Care Among Aged - Competing Renewal,98966,HSOD,Health Services Organization and Delivery Study Section,,,9,241350,
8600150,R01,CA,5,N,02/06/2014,01/24/2014,12/31/2014,395,R01CA108535,SCHOOLS OF MEDICINE,PA-07-070,5R01CA108535-09,NCI:265670\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,DETROIT,UNITED STATES,PATHOLOGY,13,001962224,US,WAYNE STATE UNIVERSITY,MI,48202,"PUBLIC HEALTH RELEVANCE:       This competing renewal application is focused on elucidating the mechanism by which Akt/Wnt activates AR, and assessing how a chemo-preventive agent (B-DIM) could inactivate AR signaling resulting in the inhibition of prostate cancer (PCa) cell growth, invasion and angiogenesis, and causing anti-tumor activity in an animal model. Moreover, based on our phase I clinical trial, we will also conduct a phase II clinical study for assessing whether B-DIM could reach prostate gland and elicit biological effects in PCa patients receiving oral B-DIM. The results of our study will help to design mechanism-based clinical trials for assessing the role of B-DIM in the prevention and/or treatment of PCa.         ",7020611;,"SARKAR, FAZLUL H.;","SONG, MIN-KYUNG H.",08/01/2004,12/31/2014,Ablation;Age-Years;androgen independent prostate cancer;Androgen Receptor;Androgens;angiogenesis;Animal Model;Animals;antitumor agent;Apoptosis;Apoptotic;base;Biological;bone;Bone neoplasms;cancer cell;Cancer Cell Growth;Cancer Etiology;Cancer Patient;cancer prevention;cancer therapy;capsule (pharmacologic);Cell Death;Cell Death Inhibition;cell growth;Cell Line;Cell Proliferation;Cell Survival;Cells;Cessation of life;Characteristics;chemotherapy;Clinical Research;Clinical Trials;Communities;Consumption;CWR22Rv1;Data;Dependence;design;Development;Diagnosis;Dietary Factors;Dietary Supplements;diindolylmethane;Disease;docetaxel;Dose;Down-Regulation;DU145;Epidemiologic Studies;Epithelial;Epithelial Cells;Exclusion;fruits and vegetables;Funding;Gene Targeting;Gene Transfer;General Population;Growth;Herb;hormone refractory prostate cancer;Hormones;Human;Human Development;human disease;In Vitro;in vitro testing;in vivo;Indole-3-Carbinol;Indoles;Induction of Apoptosis;Inhibition of Cell Proliferation;innovation;interest;Intervention;Investigation;Killings;Knowledge;LNCaP;male;Malignant neoplasm of prostate;Malignant Neoplasms;MAP Kinase Gene;Mediating;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Micronutrients;Minority;Molecular;mutant;Mutate;Names;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Nuclear;Oncogenic;Operative Surgical Procedures;Oral;Oral Administration;Pathway interactions;Patients;PC3 cell line;Phase;Phase I Clinical Trials;Phosphorylation;Phytochemical;Prevention;Prevention strategy;Prevention therapy;Preventive;Process;Prostate;prostate cancer cell;Prostate carcinoma;Prostatic Neoplasms;protective effect;public health medicine (field);public health relevance;Publications;Receptor Cell;receptor function;Receptor Signaling;Refractory;Regulation;Reporting;Research;research study;Residual Tumors;Resistance;response;Role;Serum;Signal Pathway;Signal Transduction;Specimen;Staging;steroid hormone;Testing;Therapeutic;therapy development;Tissue Harvesting;Tissues;Transcriptional Regulation;treatment strategy;tumor;tumor growth;tumor progression;Tumor Tissue;Xenograft Model,Novel Targets of Indoles in Prostate Cancer,108535,CDP,Chemo/Dietary Prevention Study Section,,,9,265670,
8598075,R01,CA,5,N,02/04/2014,01/01/2014,12/31/2014,396,R01CA138401,,PA-10-067,5R01CA138401-05,NCI:269597\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,GRAND RAPIDS,UNITED STATES,,03,047593173,US,SPECTRUM HEALTH HOSPITALS,MI,49503," Project Narrative SPARC promotes glioblastoma invasion in vitro and in vivo by activating a signaling pathway that increases phosphorylation of HSP27, and PTEN is a tumor suppressor gene that suppresses SPARC-induced migration in vitro and in vivo. We propose that the loss of PTEN, commonly observed in glioblastomas, promotes HSP27 phosphorylation by SPARC, commonly upregulated in glioblastomas. We propose that these studies will demonstrate that pHSP27 inhibition in the commonly occurring SPARC-positive, PTEN-deleted GBMs can have a significant impact on inhibiting glioma cell invasion and is an important clinical strategy for glioma patients.",7920234;,"REMPEL, SANDRA ANN;","JHAPPAN, CHAMELLI ",01/04/2011,12/31/2015,Actins;Animals;Behavior;Cell Line;Cell Survival;Cells;Cellular Morphology;chemotherapy;Clinical;Cysteine;Cytoskeleton;Diagnosis;Extracellular Matrix;Glioblastoma;Glioma;Heat shock proteins;HSPB1 gene;human tissue;In Vitro;in vivo;Integrin beta Chains;Malignant neoplasm of brain;MAP Kinase Gene;MAPK14 gene;MAPKAPK-2;member;migration;Mutate;neoplastic cell;Patients;Phosphorylation;Property;protein function;Proteins;PTEN gene;public health relevance;Radiation;Resistance;Signal Pathway;Testing;therapeutic target;Time;tumor;Tumor Cell Invasion;Tumor Suppressor Genes,HSP27: A modulator and therapeutic target of SPARC-induced glioma invasion.,138401,TPM,Tumor Progression and Metastasis Study Section,,,5,269597,
8607903,R01,CA,5,N,02/05/2014,02/01/2014,01/31/2015,396,R01CA139120,SCHOOLS OF MEDICINE,PA-07-070,5R01CA139120-05,NCI:343173\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,PHARMACOLOGY,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"PUBLIC HEALTH RELEVANCE: The proposed studies will characterize the relevance of small GTPase function in signaling by ErbB receptors, focusing in breast cancer models. We identified a novel guanine nucleotide exchange factor (GEF) that mediates proliferative signaling in breast cancer cells in response to ligands for the EGF receptor and ErbB3 receptor. This GEF, termed phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchanger-1, seems to be up-regulated in breast cancer, and probably plays a role in the progression of the disease. Studies will be pursued in cellular and animal models to elucidate its relevance in the etiology of breast cancer and in the context of ErbB receptors.            ",1878620;,"KAZANIETZ, MARCELO GABRIEL;","AULT, GRACE S.",04/15/2010,01/31/2015,Actins;Address;Affect;Anchorage-Independent Growth;Animal Model;base;Biological Assay;Breast Cancer Cell;Breast Cancer Model;Breast Carcinoma;Cancer cell line;Cell model;cell motility;Cell physiology;Cells;chemokine;CXCR4 gene;Cytoskeleton;Disease;Disease Progression;Dissociation;Down-Regulation;Epidermal Growth Factor;Epidermal Growth Factor Receptor;ERBB2 gene;ErbB4 gene;Estrogen Antagonists;Etiology;Family;Fluorescence Resonance Energy Transfer;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Amplification;Gene Mutation;Goals;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heregulin;Human;inhibitor/antagonist;Isoenzymes;Lead;Ligands;malignant breast neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Mediating;Mediator of activation protein;member;Membrane;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;Mutate;Neoplasm Metastasis;neutrophil;Normal Cell;novel;Nude Mice;outcome forecast;overexpression;Pathway interactions;Pertussis Toxin;Phosphatidylinositols;Play;prevent;prognostic;Properdin;Property;Protein Tyrosine Kinase;Proteins;PTEN gene;public health relevance;receptor;receptor coupling;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Relative (related person);Resistance;response;rho;rho GTPase-activating protein;RNA Interference;Role;Signal Transduction;Stimulation of Cell Proliferation;Testing;Therapeutic;Tissue Banking;Tissue Banks;Toxin;Trans-Activation (Genetics);tripolyphosphate;tumor;tumor progression;tumorigenesis;tumorigenic;Tumorigenicity;Up-Regulation (Physiology);wortmannin,ErbB receptor signaling via small G-proteins in breast cancer,139120,MONC,Molecular Oncogenesis Study Section,,,5,343173,
8607513,R01,CA,5,N,02/04/2014,02/01/2014,01/31/2015,393,R01CA140286,,PA-07-070,5R01CA140286-05,NCI:296585\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MAYO CLINIC ROCHESTER,MN,55905," Project Narrative Breast cancer is a heterogeneous disease with respect to etiology and prognosis. By studying risk factors for well-defined breast cancer subtypes, we will gain insight into etiologic pathways for these subtypes as well as better inform a woman's breast cancer risk and allow for targeted screening and prevention strategies. We will combine four large nested case-control studies to examine the association of one of the strongest and potentially modifiable risk factors, MD, with breast cancer molecular and histologic subtypes and develop a risk model for breast cancer and the molecular subtypes.",2072556;1859008 (contact);,"KERLIKOWSKE, KARLA M;VACHON, CELINE M (contact);","SHELBURNE, NONNIEKAYE F",04/01/2010,01/31/2015,abstracting;Address;Age;Area;Atypia;Behavior;Biological Factors;Biology;Biopsy;Blood;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Model;Breast Cancer Risk Assessment Tool;Breast Cancer Risk Factor;breast density;cancer risk;Cancer-Predisposing Gene;Categories;Classification;Clinical;Clinical Data;clinical risk;cohort;Cohort Studies;Collaborations;digital;Dimensions;Disease;Epidermal Growth Factor;ERBB2 gene;Estrogens;Etiology;Evaluation;Film;Fractals;Future;Gene Expression Profile;Gene Expression Profiling;General Population;Health;Heterogeneity;Histologic;Histopathologic Grade;Hormone Receptor;Human;Immunohistochemistry;improved;insight;malignant breast neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammographic Density;Mammography;mammography registry;Measures;Methods;Modeling;modifiable risk;Molecular;molecular modeling;Molecular Models;neoplasm registry;Nested Case-Control Study;Nodal;novel;Nurses'Health Study;outcome forecast;Pathologic;Pathology Report;Pathway interactions;Patient Self-Report;Performance;Population;Prevention strategy;Progesterone;Protocols documentation;Questionnaires;response;Risk;Risk Factors;San Francisco;screening;Self-Administered;statistics;surveillance strategy;Tissues;trait;tumor;Woman,Risk factors for breast cancer molecular subtypes,140286,ZRG1,Special Emphasis Panel,,,5,296585,
8606427,R01,CA,5,N,02/05/2014,02/01/2014,01/31/2015,396,R01CA140432,SCHOOLS OF MEDICINE,PA-07-070,5R01CA140432-05,NCI:269004\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,OMAHA,UNITED STATES,BIOCHEMISTRY,02,168559177,US,UNIVERSITY OF NEBRASKA MEDICAL CENTER,NE,681987835, Relevance: This proposal will help to understand the mechanism of metastatic progression of prostate cancer and is therefore important for the development of novel and effective therapies. It will also help to predict the outcome of currently available therapies in prostate cancer patients like radiation and hormonal ablation.,7693410;,"DATTA, KAUSTUBH;","SNYDERWINE, ELIZABETH G",02/01/2010,01/31/2015,Ablation;abstracting;Address;Androgens;Animal Model;Apoptosis;cancer cell;Cancer Etiology;Cancer Patient;cancer recurrence;Cellular Stress;Cessation of life;Clinical Research;cohort;Complex;Cutaneous;deprivation;Development;Disease;effective therapy;Failure (biologic function);Frequencies (time pattern);Goals;Hormonal;Human;human FRAP1 protein;Hypoxia;Immunocompromised Host;implantation;In Vitro;Ionizing radiation;Knockout Mice;lymph nodes;Lymphangiogenesis;Lymphatic vessel;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;meetings;men;Metastatic Prostate Cancer;Modeling;Molecular;Mortality Vital Statistics;mouse model;Mus;Neoplasm Metastasis;Neuropilin-2;new growth;NKX3-1 gene;novel;Outcome;Oxidative Stress;paracrine;Pathway interactions;Patients;Process;prognostic;Prognostic Marker;prostate cancer cell;Prostatectomy;Proto-Oncogene Proteins c-akt;PTEN gene;Publications;Radiation;Radiation therapy;receptor;Recurrence;Refractory;Resistance;Role;Specimen;Staging;Stream;Stress;Therapeutic Intervention;therapeutic target;therapy resistant;tissue culture;Tissues;Transgenic Mice;Transgenic Organisms;tumor;Vascular Endothelial Growth Factor C;Western World,The role of VEGF-C in resisting stress in prostate cancer,140432,TPM,Tumor Progression and Metastasis Study Section,,,5,269004,
8610254,R01,CA,5,N,02/05/2014,02/01/2014,01/31/2015,395,R01CA140980,,PA-07-070,5R01CA140980-05,NCI:353238\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,,49,020520466,US,SANFORD-BURNHAM MEDICAL RESEARCH INSTIT,CA,920371005,"PUBLIC HEALTH RELEVANCE: We propose to study the role of Bcl-2 interaction with p85a in mediating the activation of PI3K/AKT in cancer cells and the underlying molecular mechanisms. Our proposed studies are anticipated to identify an important new survival signaling pathway in cancer cells, which may serve as a new drug target.         ",1891537;,"ZHANG, XIAO-KUN;","MISRA, RAJ N.",04/01/2010,01/31/2015,Address;AKT Signaling Pathway;Animals;Apoptosis;Apoptotic;base;BCL2 gene;Binding (Molecular Function);Biological Assay;cancer cell;Cancer cell line;cell growth;Cell membrane;Cell Survival;Cells;chemotherapy;Complex;Development;Disease;Drug Targeting;Endoplasmic Reticulum;Epidermal Growth Factor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Face;Family;Fluorescence Polarization;Future;Growth Factor;Human;In Vitro;in vivo;inhibitor/antagonist;interdisciplinary approach;Intracellular Membranes;kinase inhibitor;lapatinib;Lesion;Malignant Neoplasms;Mediating;member;Membrane;Mitochondria;Molecular;Molecular Conformation;mutant;neoplastic cell;novel;novel therapeutics;Nuclear Envelope;Nuclear Receptors;Outer Mitochondrial Membrane;overexpression;Pathway interactions;Peptides;peptidomimetics;Pharmaceutical Preparations;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Phosphotyrosine;Play;polyproline;Proline;Proteins;Proto-Oncogene Proteins c-akt;public health relevance;Publishing;Radiation therapy;Regulation;Reporting;Resistance;Role;screening;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Protein;small molecule;Solid Neoplasm;Specificity;Testing;tool,The Bcl-2-p85/PI3K signaling axis,140980,DMP,Drug Discovery and Molecular Pharmacology Study Section,,,5,353238,
8611716,R01,CA,5,N,02/03/2014,02/01/2014,01/31/2015,394,R01CA142842,SCHOOLS OF MEDICINE,PA-07-070,5R01CA142842-05,NCI:276321\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,04,044387793,US,DUKE UNIVERSITY,NC,27705," The proposed studies will develop a minimally invasive imaging technique to enable physicians to determine whether pulmonary lesions detected on a cancer patient's x-ray CT scan are metastases. Such information permits the physician to administer the right therapy at the earliest possible stage in the patient's treatment. The proposed research has relevance to public health because new tools in imaging pulmonary cancers will not only improve patient treatment, but will also accelerate research to develop better therapies.",9766365;8543746 (contact);,"BRANCA, ROSA TAMARA;DRIEHUYS, BASTIAAN  (contact);","MENKENS, ANNE E",04/01/2010,01/31/2015,anticancer research;Architecture;base;Benign;Biomedical Technology;Bleomycin;Blinded;Camping;cancer cell;cancer imaging;Cancer Patient;Cessation of life;Clinical;Clinical Management;Collaborations;cost;Custom;Data;Detection;Development;Diagnostic;Disease;Disseminated Malignant Neoplasm;Environment;foot;Gases;Goals;Head;Health;Healthcare Systems;Histology;Histopathology;Housing;Image;Image Analysis;Imagery;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;Injection of therapeutic agent;innovation;Intravenous;iron oxide;Lesion;Lung;lung imaging;Lung nodule;Magnetic Resonance Imaging;malignant breast neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Metastatic Lesion;Metastatic Neoplasm to the Lung;Methods;Microscopy;minimally invasive;Mission;Modality;Modeling;Molecular;molecular imaging;mouse model;Mus;nanoparticle;Neoplasm Metastasis;Noble Gases;Organ;Outcome;Patients;Physicians;Positioning Attribute;Positron-Emission Tomography;Predisposition;Primary Neoplasm;public health medicine (field);Pulmonary Pathology;quantum;Reader;Relative (related person);Relaxation;Research;Resolution;Sensitivity and Specificity;Specificity;Staging;success;Techniques;Technology;Testing;Theoretical model;theories;Therapeutic;Time;tool;Translations;tumor;United States National Institutes of Health;Visual;Work;X-Ray Computed Tomography,Sensitive and Specific Molecular Imaging of Pulmonary Nodules,142842,BMIT,Biomedical Imaging Technology Study Section,,,5,276321,
8607153,R01,CA,5,N,02/04/2014,02/01/2014,01/31/2015,395,R01CA148707,OVERALL MEDICAL,PA-10-067,5R01CA148707-04,NCI:622676\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,PSYCHOLOGY,09,800772139,US,UT MD ANDERSON CANCER CTR,TX,770304009,"PUBLIC HEALTH RELEVANCE: The proposed study will examine the efficacy of incorporating acupuncture alongside radiotherapy for patients with head and neck cancer. If we find that acupuncture diminishes the side effects experienced by patients undergoing radiotherapy, then this type of program can be incorporated into the treatment plan as the standard of care.         ",1861107;,"COHEN, LORENZO;","O'MARA, ANN M.",02/15/2011,01/31/2015,Acupuncture procedure;Adverse effects;Amifostine;Area;base;Blinded;Buffers;Calcitonin Gene-Related Peptide;Cancer Hospital;Cancer Patient;Chewing Gum;China;Deglutition Disorders;Desire for food;Effectiveness;Europe;Expectancy;experience;Head and Neck Cancer;Head and neck structure;improved;Incidence;Lead;Measures;Nasopharynx Carcinoma;Nutritional;Outcome;Patient Self-Report;Patients;Pharmacologic Substance;Pilocarpine;pilot trial;Placebo Control;placebo controlled study;prevent;primary outcome;programs;Proteins;public health relevance;Quality of life;Questionnaires;Radiation;Radiation therapy;Randomized;randomized placebo controlled trial;Research;response;Role;Saliva;Salivary;Severities;Sleep;standard care;standard of care;success;swallowing painful;Symptoms;Taste Perception;treatment duration;treatment effect;treatment planning;United States;Universities;University of Texas M D Anderson Cancer Center;Vasoactive Intestinal Peptide;Viscosity;Xerostomia,Placebo Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia,148707,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",,,4,622676,
8607156,R01,CA,5,N,02/05/2014,02/01/2014,01/31/2015,396,R01CA149321,HOSPITALS,PA-07-070,5R01CA149321-05,NCI:286214\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,09,800772139,US,UT MD ANDERSON CANCER CTR,TX,770304009,"PUBLIC HEALTH RELEVANCE:  Although the extensive studies have been made for the role of PI3K/Akt signaling in cancers, how Akt membrane localization and phosphorylation is regulated remains largely unknown. Our study reveals that a novel posttranslational modification is operated on Akt and that Akt K63-linked polyubiquitnation by E3 ligase TRAF6 may play important roles in Akt membrane localization, phosphorylation, and tumorigenesis. Understanding the mechanism by which Akt activation is regulated may not only provide a great insight into how the oncogenic Akt signaling is regulated, but also offer the important therapeutic implications for human cancers.            ",9090324;,"LIN, HUI-KUAN;","JHAPPAN, CHAMELLI ",04/01/2010,01/31/2015,Affinity Chromatography;Apoptosis;base;Biological Process;cancer therapy;Cell Proliferation;Cell Survival;Cells;Clinical;Data;Deubiquitinating Enzyme;Deubiquitination;Development;Goals;Human;in vivo;innovation;insight;Link;Malignant Neoplasms;Mediating;Membrane;Molecular;Neoplasm Metastasis;novel;Oncogenic;Outcome;Phosphorylation;Play;Polyubiquitination;Post-Translational Protein Processing;Principal Investigator;programs;protein metabolism;public health relevance;Regulation;Research;Role;Signal Transduction;Testing;Therapeutic;therapeutic target;Time;TRAF6 gene;Translations;tumor progression;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;Work,Regulation of Akt signaling activation by polyubiquitination,149321,CSRS,Cellular Signaling and Regulatory Systems Study Section,,,5,286214,
8657015,R01,CA,5,N,02/04/2014,02/01/2014,01/31/2015,393,R01CA158319,SCHOOLS OF MEDICINE,PA-10-067,5R01CA158319-03,NCI:285728\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,MILWAUKEE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,937639060,US,MEDICAL COLLEGE OF WISCONSIN,WI,532263548," Rates of esophageal adenocarcinoma (EAC) have dramatically increased throughout the Western world during the last thirty years and this is an extremely deadly cancer with the five-year survival rates of only 18% supporting the urgent need for improved preventive strategies. Studies proposed in this application will determine the mechanisms involved in cranberry proanthocyanidins (C-PAC) cell death-inducing capacity utilizing a diverse panel of human esophageal cell lines, assess the in vivo efficacy of C-PAC for the prevention of EAC utilizing a clinically relevant reflux-induced rat model and test the ability of a novel imaging technology to detect very early changes in cellular structures. The hypothesis driven and mechanistically focused studies proposed herein will provide critical information necessary for moving forward with clinical interventions in patients at increased risk for EAC, including those suffering from Barrett's esophagus.         ",7064313;,"KRESTY, LAURA A.;","RICHMOND, ELLEN S.",02/28/2012,01/31/2017,Acids;Adenocarcinoma Cell;Alcohol consumption;Anastomosis - action;Animals;Apoptosis;Apoptotic;Area;Autophagocytosis;Barrett Esophagus;base;Bile Acids;Biological Assay;Biological Markers;cancer type;carcinogenesis;Cell Cycle Arrest;Cell Death;Cell Death Induction;Cell Line;Cell Proliferation;Cell Survival;Cells;Cellular Structures;Cessation of life;Chemopreventive Agent;Clinical;clinically relevant;cohort;Cranberries;cytokine;Defect;Development;Diet;Disease;DNA Damage;Dose;drinking water;Environment;Enzymes;Epithelial;Epithelium;Esophageal;Esophageal Adenocarcinoma;Esophageal Intraepithelial Neoplasia;Esophageal Tissue;Esophagus;Evaluation;Foundations;Frequencies (time pattern);Gastroesophageal reflux disease;Gene Expression;Gene Expression Profile;Goals;Growth;Human;Human Cell Line;Image;imaging modality;Imaging technology;improved;In Vitro;in vivo;Intervention;Investigation;Knowledge;Lesion;light scattering;Link;M cell;Malignant neoplasm of esophagus;Malignant Neoplasms;MAP Kinase Gene;MAPK14 gene;MAPK3 gene;MAPK8 gene;Measurable;Measurement;Measures;metabolomics;Modeling;Molecular;molecular marker;Monitor;Morphology;Necrosis;NFKB Signaling Pathway;novel;Nuclear;Nude Mice;Obesity;Operative Surgical Procedures;Optical Coherence Tomography;oral cavity epithelium;Outcome;outcome forecast;Pathology;Pathway Analysis;Patients;Pharmaceutical Preparations;Phase;Plants;pre-clinical;pre-clinical research;Premalignant;Prevention;Prevention strategy;Preventive;Proanthocyanidins;Procedures;Property;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Rattus;Reflux;Research;Research Project Grants;Research Proposals;Resistance;Risk;Risk Factors;Risk Reduction;Rodent;Rodent Model;S Phase;screening;Signal Pathway;Signal Transduction;Signaling Molecule;Staging;stem;Stomach;Surgical Models;Survival Rate;Techniques;Testing;Time;Tissues;Tobacco use;Toxic effect;Translating;tumor;Tumor Suppressor Genes;United States;Validation;Vesicle;Western World;Xenograft procedure,Inhibition of Reflux-Induced Esophageal Adenocarcinoma by Proanthocyanidins,158319,CDP,Chemo/Dietary Prevention Study Section,,,3,285728,
8603232,R01,DA,5,N,02/07/2014,02/01/2014,01/31/2015,279,R01DA031201,SCHOOLS OF MEDICINE,PA-10-067,5R01DA031201-04,NIDA:535388\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,CORAL GABLES,UNITED STATES,PSYCHIATRY,27,052780918,US,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,FL,331462926,"PUBLIC HEALTH RELEVANCE: Methamphetamine (meth) abuse particularly among MSM in South Florida has skyrocketed. Although endocrine outcomes in HIV-1 infection as well as drug abusers with HIV- 1 infection have been investigated, there is scarcity of information regarding such outcomes in HIV-1+ meth abusing MSM. This proposal investigates adrenal, thyroid and insulin activities in this population. It is proposed that adverse endocrine outcomes may result in an enormous medical burden.         ",1873101;,"KUMAR, MAHENDRA;","KHALSA, JAGJITSINGH H.",04/01/2011,01/31/2016,Acquired Immunodeficiency Syndrome;Address;Adrenal Glands;adverse outcome;African American;Antibodies;Caucasians;Caucasoid Race;Cocaine;Cocaine Abuse;Comorbidity;Contracts;Corticotropin;Country;CRH gene;Cytokine Gene;Dexamethasone;Drug abuse;Drug abuser;Endocrine;Endocrine system;Euphoria;Florida;Gene Expression;Glucose;Hispanics;HIV;HIV-1;Hydrocortisone;Hyperglycemia;Hyperthyroidism;Illicit Drugs;Incidence;Individual;Infection;Inflammatory;Insulin;Insulin Resistance;insulin secretion;Intervention;Investigation;Iodide Peroxidase;Lead;Medical;men;men who have sex with men;Methamphetamine;methamphetamine abuse;Opioid;Outcome;Oxidative Stress;Participant;Pharmaceutical Preparations;Population;public health relevance;Reporting;response;Risk Factors;Rodent;Syndrome;Testing;therapy design;Thyroid Gland;Time;United States,HIV-1 Infection in Methamphetamine Abusers: Endocrine Outcomes,31201,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,,4,535388,
8605868,R01,DA,5,N,02/04/2014,02/01/2014,01/31/2015,279,R01DA031202,SCHOOLS OF MEDICINE,PA-10-129,5R01DA031202-04,NIDA:305775\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,MINNEAPOLIS,UNITED STATES,SURGERY,05,555917996,US,UNIVERSITY OF MINNESOTA,MN,554552070," The latest statistics on the world epidemic of AIDS &HIV (UNAIDS/WHO, November 2005) report that at least 40 million people are infected with HIV with nearly 6 million cases of AIDS world-wide. There is a strong correlation between chronic drug use and increase susceptibility to HIV infection. Chronic drug users accounts for approximately a third of all cases of AIDS in the USA and the progression to AIDS dementia is markedly accelerated in opiate drug abusers. This proposal postulates that modulation of microRNAs, mir-155 and miR-146a, by opioid drug abuse and HIV1- TAT may be a plausible mechanism for the persistent immune activation in these patients. Until now there are no published studies implicating miRs in the dysregulated immune activation observed in HIV infected drug abusing population. These studies will allow for the delineation of the mechanisms and allow for the development of new therapeutic strategies to attenuate immune activation and reverse HIV disease progression both in HIV infected patients and in HIV infected drug abusing population.         ",1968493;1938024 (contact);,"RAMAKRISHNAN, SUNDARAM;ROY, SABITA  (contact);","SATTERLEE, JOHN S",03/01/2011,01/31/2016,Accounting;Acquired Immunodeficiency Syndrome;AIDS Dementia Complex;Animal Model;Animals;Attenuated;attenuation;Automobile Driving;Bacteria;Bacterial Translocation;Biological Assay;Biological Process;chemokine;Chronic;Computer Analysis;cytokine;Data;Development;Disease Progression;driving force;Drug abuse;Drug abuser;Drug usage;Drug user;Endotoxins;Epidemic;Event;Feedback;Functional RNA;Genes;Genetic;Genetic Transcription;Heroin;HIV;HIV Infections;HIV-1;Human;immune activation;in vivo;Individual;Inflammation;Inflammatory;Intravenous;IRAK1 gene;Knowledge;Ligands;macrophage;Mediating;MicroRNAs;Mitogen-Activated Protein Kinases;Modeling;Morphine;Mus;non-drug;novel therapeutics;Opiates;Opioid;Patients;Pharmaceutical Preparations;Placebos;Plasma;Population;Post-Transcriptional Regulation;Predisposition;prevent;Production;Progressive Disease;Promotor (Genetics);protein activation;Publishing;Receptor Signaling;Regulatory Pathway;Reporting;response;Role;Serum;Signal Transduction;Signaling Protein;Site;statistics;Subfamily lentivirinae;T-Cell Activation;Testing;toll-like receptor 4;TRAF6 gene;Transcription Coactivator;Transgenic Animals;Viral Load result,Role of microRNAs in opioid drug abuse induced persistent Inflammation and HIV di,31202,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,,4,305775,
8462234,R01,DA,5,N,02/03/2014,02/01/2014,01/31/2015,279,R01DA031687,SCHOOLS OF MEDICINE,PA-10-067,5R01DA031687-03,NIDA:523541\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,BURLINGTON,UNITED STATES,PSYCHIATRY,00,066811191,US,UNIVERSITY OF VERMONT &ST AGRIC COLLEGE,VT,05405," The most widely-accepted animal model of nicotine withdrawal states stopping nicotine makes rewarding events become less rewarding. The current study will test if this is true in humans. If the investigators find tobacco abstinence does make rewards less rewarding, this would suggest new symptoms to add to official descriptions of nicotine withdrawal. It would also suggest the need to develop new behavioral and pharmacological interventions to correct this problem. If stopping smoking does not make rewards less rewarding, this would suggest that this animal model does not apply to the human condition and a need to continue the search for an animal model of tobacco withdrawal that is relevant to smokers'stopping smoking.            ",1877536;,"HUGHES, JOHN R;","KAUTZ, MARY A.",08/15/2011,01/31/2015,Abstinence;Acute;Affective;Anhedonia;Animal Experimentation;Animal Model;Animals;Back;base;Behavior Therapy;Behavioral;Chronic;Clinical;Clinical Data;Communities;comparison group;Event;Exhibits;Exposure to;Human;Incidence;Intervention;Measures;Mental Depression;Methods;Modeling;Modification;Motivation;Nicotine;Nicotine Withdrawal;Patient Self-Report;Pattern;Pharmacological Treatment;pleasure;pre-clinical;Pre-Clinical Model;Process;Psychological reinforcement;Psychotherapy;Recruitment Activity;Relapse;Reporting;Research Personnel;Rewards;Schedule;Selection Bias;Smoke;Smoker;Smoking;smoking cessation;Symptoms;Testing;Time;Tobacco;tobacco abstinence;Tobacco Dependence;Withdrawal;Withdrawal Symptom,Does smoking cessation cause anhedonia?  A test of pre-clinical findings,31687,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,,3,523541,
8623124,R01,DA,5,N,02/04/2014,01/01/2014,12/31/2014,279,R01DA034547,SCHOOLS OF MEDICINE,PA-10-129,5R01DA034547-02,NIDA:327203\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,MIAMI,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,21,071298814,US,FLORIDA INTERNATIONAL UNIVERSITY,FL,33199,"PUBLIC HEALTH RELEVANCE: The proposed research will elucidate the cocaine and HIV-associated epigenetic mechanisms in the development of HIV-associated neurocognitive disorders (HAND). Further, we will also evaluate the efficacy of transferrin coupled liposomal nanoformulation to transmigrate across an in vitro blood-brain barrier (BBB) model as well as in the HIV-E SCID cocaine mouse model. These studies will have translational significance for therapeutic targeting and control of HAND in cocaine abusing HIV-infected patients.              ",1873959;,"NAIR, MADHAVAN P.;","SATTERLEE, JOHN S",03/01/2013,12/31/2017,Abbreviations;Acetylation;Acquired Immunodeficiency Syndrome;AIDS/HIV problem;Animal Model;Astrocytes;Behavioral;Binding (Molecular Function);Blood - brain barrier anatomy;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Cells;Central Nervous System Diseases;chromatin modification;chromatin remodeling;Clinical Research;Cocaine;Cocaine Abuse;cocaine use;Cocaine Users;Cognitive;cognitive function;Contracts;Coupled;CREB1 gene;Cyclic AMP Response Element;Dendritic Spines;density;Development;Disease;Disease Progression;Down-Regulation;Drug abuse;Drug abuser;Drug Addiction;drug of abuse;Electrical Resistance;Epigenetic Process;Gene Expression;gene repression;Genes;Goals;Growth;HDAC2 gene;Hippocampus (Brain);histone acetyltransferase;histone deacetylase 2;Histone Deacetylation;Histones;HIV;HIV Infections;HIV-1;Human;Impairment;In Vitro;Individual;Infection;inhibitor/antagonist;Injection of therapeutic agent;Liposomes;Mediating;Memory;Memory impairment;Microglia;Modeling;Modification;Molecular;Motor;mouse model;nanoformulation;nervous system disorder;Neurocognitive;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;Neuropathogenesis;nuclease;Patients;Play;Predisposition;Proteins;public health relevance;Publishing;Rattus;receptor mediated endocytosis;Regulatory Element;Reporting;Research;response;Risk Factors;Role;Self Administration;Small Interfering RNA;Synaptic plasticity;Synaptic Transmission;tat Protein;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Transcriptional Regulation;Transfection;Transferrin;Transferrin Receptor;Trichostatin A;Up-Regulation (Physiology);Valproic Acid;Virus,Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2,34547,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,,2,327203,
8603854,R01,DC,5,N,02/06/2014,02/01/2014,01/31/2015,173,R01DC000937,SCHOOLS OF MEDICINE,PA-10-067,5R01DC000937-23,NIDCD:461475\,Research Projects,2014,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,ROOTSTOWN,UNITED STATES,ANATOMY/CELL BIOLOGY,16,077779882,US,NORTHEAST OHIO MEDICAL UNIVERSITY,OH,44272," Dysfunction in the amygdala may play a critical role in the abnormal emotional responses to speech and other sounds that occurs in autism, schizophrenia, post-traumatic stress, and tinnitus. This work will establish how amygdalar neurons normally function in response to speech-like sounds, laying groundwork for study of the function of the amygdala in animal models of these disorders. !            ",1863755;,"WENSTRUP, JEFFREY JAMES;","PLATT, CHRISTOPHER ",12/01/1990,01/31/2017,Acoustic Stimulation;Acoustics;Address;Affect;Aggressive behavior;Amygdaloid structure;Animal Model;Animals;Auditory;auditory stimulus;Autistic Disorder;awake;base;Behavior;Behavioral;CBA/CaJ Mouse;Chiroptera;Chronic;Communication;conditioned fear;Cues;Dependence;Discrimination (Psychology);Disease;Emotional;Female;Freezing;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Hearing;Human;improved;Individual;information processing;Long-Term Effects;male;Measures;Mus;neuromechanism;Neurons;neurophysiology;Odors;Pattern;Play;post-traumatic stress;Process;Randomized;research study;response;restraint;Role;Schizophrenia;Sensory;Signal Transduction;social;sound;Speech;Stimulus;Structure;Testing;Thalamic structure;Tinnitus;Training;vocalization;Work,Auditory Information Processing in the Amygdala,937,AUD,Auditory System Study Section,,,23,461475,
8600626,R01,DE,5,N,02/05/2014,02/01/2014,01/31/2015,121,R01DE013023,BIOMED ENGR/COL ENGR/ENGR STA,PA-07-070,5R01DE013023-15,NIDCR:359627\,Research Projects,2014,NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH,,CAMBRIDGE,UNITED STATES,ENGINEERING (ALL TYPES),07,001425594,US,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,MA,02139,"PUBLIC HEALTH RELEVANCE: The goal of this renewal grant is to use our existing biodegradable and biocompatible elastomers that can be tailored for specific soft tissue applications, to develop new approaches for treating intestinal defects. We will address the overall hypothesis that functional tissue engineering of biomimetic small intestine requires microfabricated elastomeric scaffolds capable of guiding the formation of the mucosa and muscular is propria layers.         ",1887697;,"LANGER, ROBERT SAMUEL;","LUMELSKY, NADYA L.",09/15/1998,01/31/2015,absorption;Address;Age;Animal Model;Applications Grants;Area;Biocompatible;Biocompatible Materials;biomaterial compatibility;Biomimetics;Biotechnology;Blood Circulation;Cardiovascular system;career;Cell Adhesion;Child;Clinical;cost;Defect;Development;Disease;elastomeric;Elastomers;Faculty;Fiber;gastrointestinal;Glycerol;Goals;Grant;High Prevalence;Human;implantation;in vitro Model;in vivo;in vivo Model;Intestinal Motility;Intestines;Journals;Life;Liquid substance;Mechanics;member;Methodology;Microfabrication;migration;Morbidity - disease rate;Morphology;Mortality Vital Statistics;Mucous Membrane;Muscle;Muscularis Mucosa;Names;Natural regeneration;Nature;novel;novel strategies;Nutrient;Operative Surgical Procedures;Pathology;Patients;Performance;Peristalsis;Pharmaceutical Preparations;poly(glycerol-sebacate);Polymers;Postdoctoral Fellow;Prevalence;Property;public health relevance;Publications;Publishing;scaffold;sebacic acid;Short Bowel Syndrome;Small Intestines;Smooth muscle (tissue);socioeconomics;soft tissue;Structure;Students;Technology;Testing;Tissue Engineering;Tissues;Tube;Universities;University Hospitals;vascular tissue engineering;Work,Novel Polymers for Tissue Engineering,13023,BMBI,Biomaterials and Biointerfaces Study Section,,,15,359627,
8607180,R01,DK,5,N,02/06/2014,02/01/2014,01/31/2015,847,R01DK075462,SCHOOL OF MEDICINE &DENTISTRY,PA-10-067,5R01DK075462-07,NIDDK:272604\,Research Projects,2014,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,28,041294109,US,UNIVERSITY OF ROCHESTER,NY,14627," Patients with calcium containing kidney stones have reduced bone mineral density and an increased rate of fractures and bone of our genetic strain of hypercalciuric stone-forming rats also has reduction in bone density and quality. We will use these rats to study the mechanism of this bone disease and test potential dietary interventions to improve bone density and quality. If the results from these animal studies are supported by studies in human hypercalciuric stone formers, they will have a substantial effect on treatment paradigms that will not only reduce recurrent stone formation but improve bone quality in hypercalciuric patients.         ",1879195;,"BUSHINSKY, DAVID A;","RASOOLY, REBEKAH S",07/01/2006,01/30/2016,Acute;Affect;Animal Model;Animals;Area;Biology;BMP2 gene;bone;Bone Density;Bone Diseases;bone quality;Bone Resorption;bone strength;bone turnover;Calcium;Calculi;Chlorthalidone;Defect;Diet;Diet Modification;Dietary Intervention;Disease;Excretory function;experience;Failure (biologic function);Family;feeding;Fracture;Functional disorder;Generations;Genetic;genetic strain;Goals;Homeostasis;Human;humerus;hypercalciuria;improved;Inbreeding;Intestines;Kidney;Kidney Calculi;Knowledge;Life;man;Measures;Mechanics;men;Nephrolithiasis;Osteogenesis;Pain;Paper;Pathogenesis;Patients;Peer Review;Productivity;Property;Publications;Rat Strains;Rattus;Recurrence;Reporting;Research;Risk;Signal Transduction;Skeleton;Snails;Source;spine bone structure;Sprague-Dawley Rats;Stress;substantia spongiosa;Testing;Thiazide Diuretics;Thick;Time;Tinea Favosa;Tissues;transcription factor;urinary;Urine;Vitamin D3 Receptor;Woman;Work;Writing,Hypercalciuria and Bone Quality in the Genetic Hypercalciuric Stone-Forming Rats,75462,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,,7,272604,
8604708,R01,DK,5,N,02/06/2014,02/01/2014,01/31/2015,847,R01DK083338,SCHOOLS OF MEDICINE,PA-10-067,5R01DK083338-04,NIDDK:296561\,Research Projects,2014,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,TUCSON,UNITED STATES,PHYSIOLOGY,07,806345617,US,UNIVERSITY OF ARIZONA,AZ,857210158,PUBLIC HEALTH RELEVANCE: Extracellular fluid and solute homeostasis is important for maintaining normal cell function throughout the body. The kidney plays a critical role in maintaining fluid and solute homeostasis and the concentrating mechanism is an essential process in accomplishing this role. The major goal of these studies is to more clearly understand the concentrating mechanism.         ,1935636;,"PANNABECKER, THOMAS LLOYD;","KETCHUM, CHRISTIAN J.",02/01/2011,01/31/2016,antidiuresis;antidiuretic;Architecture;base;Blood Vessels;Cell physiology;Collaborations;countercurrent chromatography;Development;Diuresis;Diuretics;Duct (organ) structure;Electrolytes;Exhibits;Exposure to;Extracellular Fluid;Frequencies (time pattern);Generations;Goals;Henle's loop;Heterogeneity;Homeostasis;In Vitro;in vivo;interstitial;Ions;Kidney;kidney medulla;Knowledge;Lateral;Lead;Limb structure;Liquid substance;Mammals;mathematical model;Measurement;Modeling;Movement;Nephrons;Nodal;Normal Cell;Permeability;Physiological;Play;Process;Production;public health relevance;Rattus;reconstruction;Rectum;Regulation;Renal function;Research;Role;Site;solute;Structure;Structure-Activity Relationship;System;Tubular formation;Urea;urinary;Urine;Vasopressins;Water;Wistar Rats;Work,Integrated Tubular and Vascular Structure and Function in Renal Inner Medulla,83338,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,,4,296561,
8604389,R01,DK,5,N,02/06/2014,02/01/2014,01/31/2015,847,R01DK087838,SCHOOLS OF MEDICINE,PA-10-067,5R01DK087838-04,NIDDK:303413\,Research Projects,2014,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,066469933,US,EMORY UNIVERSITY,GA,30322,"PUBLIC HEALTH RELEVANCE: Sodium and urea are the two major solutes that contribute to the medullary osmolarity gradient in kidney. Urea reabsorption in kidneys is mainly mediated by urea transporter UT-A1 in the inner medullary collecting duct (IMCD) epithelial cells. Although the first urea transporter was cloned in 1993 and significant progress has been achieved, the mechanisms for its regulation are still unclear. The aim of the current application is to explore the molecular mechanisms of how UT-A1 is regulated by accessory proteins. We are particularly interested in a group of small molecular weight proteins (20~30kDa) such as caveolin and 14-3-3. We have preliminary data suggesting that these proteins may play important roles in the UT-A1 urea transporter trafficking, recycling, activation, and degradation. Our long-term goal is to screen and develop small-molecule modulators of these proteins that could affect UT-A1 function in vivo for potential therapeutic interventions for total body fluid overloaded diseases such as hypertension, congestive heart failure, cirrhosis, and nephrotic syndrome.         ",8636474;,"CHEN, GUANGPING;","KETCHUM, CHRISTIAN J.",02/01/2011,01/31/2016,14-3-3 Proteins;Adrenergic Receptor;Affect;Binding (Molecular Function);Binding Proteins;Biology;Body Fluids;Carrier Proteins;Caveolae;caveolin 1;Caveolins;cell growth regulation;Cell membrane;Cell Membrane Proteins;Cell physiology;Cell surface;Cell Surface Proteins;Cells;Chemicals;Cholesterol;Cirrhosis;Collaborations;Complex;Congestive Heart Failure;Data;Disease;drug discovery;Duct (organ) structure;Epithelial Cells;Equilibrium;Family;Fluid overload;Goals;Hypertension;in vivo;insight;interest;Intracellular Membranes;Intracellular translocation;Kidney;Knockout Mice;Ligands;Link;Mammals;MDM2 gene;Mediating;Membrane;Membrane Microdomains;Membrane Protein Traffic;Membrane Proteins;Molecular;Molecular Weight;Nephrotic Syndrome;Osmolar Concentration;Pathway interactions;Phosphorylation;Physiological;Play;Potassium Channel;Process;protein function;Protein Isoforms;protein phosphatase inhibitor-2;protein protein interaction;Proteins;public health relevance;Rattus;receptor internalization;Recruitment Activity;Recycling;Regulation;Research;response;Retrieval;Role;salt sensitive;Scaffolding Protein;Sequence Analysis;Serine;Signal Transduction;small molecule;Sodium;solute;Sorting - Cell Movement;Specificity;Stimulus;Structural Protein;Therapeutic Intervention;Threonine;Time;trafficking;Ubiquitination;Urea;urea transporter;urinary;Vasopressins;Water;yeast two hybrid system;Yeasts,Small Proteins and Renal Urea Transport Regulation,87838,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,,4,303413,
8608460,R01,DK,5,N,02/06/2014,02/01/2014,01/31/2015,847,R01DK087967,SCHOOLS OF MEDICINE,PA-12-270,5R01DK087967-04,NIDDK:287753\,Research Projects,2014,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BIRMINGHAM,UNITED STATES,UROLOGY,07,063690705,US,UNIVERSITY OF ALABAMA AT BIRMINGHAM,AL,35294,"PUBLIC HEALTH RELEVANCE: Despite evidence demonstrating a lack of OxF colonization as a risk factor for calcium oxalate stone formation, very little is known about its biology, the factors that affect its growth and distribution, and its impact on oxalate handling. The purpose of this proposal is to use a mouse model of OxF colonization to facilitate our understanding of these poorly understood areas.            ",9494644;,"KNIGHT, JOHN;","RASOOLY, REBEKAH S",02/01/2011,01/31/2016,absorption;Accounting;Address;Affect;animal model development;Animals;Area;Bacteria;Biological;Biology;Calcium Oxalate;Calculi;Carbon;Clinical;clinically significant;Colon;cost;Development;Diagnosis;Diet;Dietary Calcium;Dietary Factors;Disease;Dose;Ensure;Enteral;environmental change;Environmental Risk Factor;Excretory function;Foundations;Genes;Genetic;Genomics;Goals;Growth;Homeostasis;Hour;Housing;Human;In Vitro;intestinal epithelium;Intestinal Secretions;Intestines;Intravenous;Kidney Calculi;Lead;Metabolic;Metabolism;Microbe;microbial;microbiome;Modeling;Modification;Molecular;mouse model;Mus;Mutation;Natural History;Nephrolithiasis;Oral;Oral Administration;Oxalates;Oxalic Acids;Oxalobacter formigenes;Pain management;Pathway interactions;Patients;Physiology;Pilot Projects;Pilum;pilus genes;Plasma;Population;Population Density;Population Distributions;Primary Hyperoxaluria;Production;Proteins;public health medicine (field);public health relevance;Rattus;Recurrence;research study;response;Risk;Risk Factors;Role;rRNA Genes;Source;Testing;Therapeutic;Time;United States;urinary;Urinary Calculi;Urine;Vertebrates;Wages,Oxalate handling and Oxalobacter formigenes colonization in a mouse model,87967,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,,4,287753,
8608429,R01,EB,5,N,02/07/2014,02/01/2014,01/31/2015,286,R01EB007327,SCHOOLS OF MEDICINE,PA-10-067,5R01EB007327-07,NIBIB:391924\,Research Projects,2014,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,MINNEAPOLIS,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,05,555917996,US,UNIVERSITY OF MINNESOTA,MN,554552070," While humans are being imaged at 3T, 7T, and soon, 10.5T, more data and understanding of RF safety at these ultra-high field strengths are needed. These RF safety issues were investigated for head imaging in the previous grant. The objective of this renewal proposal therefore is to continue the investigation of high frequency RF heating in the human body to improve RF safety and imaging performance for ultra-high field MRI. Safety will be better assured by developing means to accurately predict and image RF heating contours in human anatomy.              ",9087808;1874431 (contact);,"SHRIVASTAVA, DEVASHISH;VAUGHAN, JOHN T (contact);","LIU, GUOYING ",04/01/2007,01/31/2016,Adult;Anatomy;base;Blood;Cartoons;Cells;Charge;Chemical Shift Imaging;Data;Development;Engineering;Equation;experience;Family suidae;Frequencies (time pattern);Goals;Grant;Guidelines;Head;Heating;Human;Human body;Image;imaging modality;improved;Industry;Investigation;Limb structure;Magnetic Resonance Imaging;Measurement;Measures;Methodology;Methods;Metric;minimally invasive;Mission;Modeling;Monitor;Motion;Nature;Pain;parent grant;patient safety;Patients;Performance;Physiology;Protocols documentation;Protons;Reagent;Safety;safety practice;safety study;Scanning;Scientist;Stress;System;Technology;Temperature;Theoretical model;theories;Thermodynamics;Thermometers;Thermometry;Time;Time Study;Tissues;Validation;Work,RF SAFETY FOR ULTRA-HIGH FIELD MRI,7327,BMIT,Biomedical Imaging Technology Study Section,,,7,391924,
8608528,R01,EY,5,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY021214,SCHOOLS OF MEDICINE,PA-10-067,5R01EY021214-04,NEI:393750\,Research Projects,2014,NATIONAL EYE INSTITUTE,,PORTLAND,UNITED STATES,OPHTHALMOLOGY,03,096997515,US,OREGON HEALTH &SCIENCE UNIVERSITY,OR,972393098,"PUBLIC HEALTH RELEVANCE: Retinal degenerative diseases are cumulatively the most frequent causes of blindness in which cells typically in the outer retina (photoreceptors and retinal pigment epithelium) are lost. This proposal focuses on the potential for replacing one such cell type, the retinal pigment epithelium, which can be engineered from various stem cell sources. The ability of these cells to rescue vision will be investigated and we will elucidate the risks of immune rejection. These findings will be key to the safe translation of this therapy into clinic for the treatment of such conditions as age-related macular degeneration.         ",1898673;,"NEURINGER, MARTHA D.;","SHEN, GRACE L",02/01/2011,01/31/2016,absorption;Address;Adult;Age;Age related macular degeneration;Aging;Allografting;Animal Model;Animals;Autologous Transplantation;Biologic Characteristic;Biological;Biological Assay;Blindness;Cell Line;Cell Therapy;Cell Transplantation;Cell Transplants;cell type;Cells;Characteristics;Chronic;Clinic;clinical practice;clinically relevant;Data;Degenerative Disorder;Disease;disorder of macula of retina;Dose;embryonic stem cell;Engineering;Evaluation;experience;Eye;Family suidae;Goals;Graft Rejection;Human;Immune;Immune response;Immune system;immunogenicity;Immunologist;Immunology;In Vitro;in vivo;induced pluripotent stem cell;Inflammation;innovation;insight;Knowledge;Left;Light;Macaca mulatta;macula;Measures;Metabolic;Methods;Mitochondria;Modeling;Molecular;Monkeys;Natural immunosuppression;nervous system disorder;Nonexudative age-related macular degeneration;nonhuman primate;novel;Nutritional Support;Operative Surgical Procedures;Organ;Outcome;oxidation;Pathogenesis;Patients;Photoreceptors;Physicians;pluripotency;Pluripotent Stem Cells;prevent;Primates;Production;Protocols documentation;public health relevance;Rattus;Recycling;Research Project Grants;Resources;Retina;retina transplantation;Retinal;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;Retreatment;Risk;Rodent;Rodent Model;Rods (Retina);Scientist;senescence;somatic cell nuclear transfer;Source;Stem cells;Structure;Structure of retinal pigment epithelium;success;Therapeutic Intervention;Time;Translational Research;Translations;Transplantation;Vision;Visual;Xenograft procedure,Evaluation of stem cell-derived retinal pigment epithelial cells for retinal dise,21214,BDPE,Biology and Diseases of the Posterior Eye,,,4,393750,
8610316,R01,EY,5,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY021820,SCHOOLS OF MEDICINE,PA-11-260,5R01EY021820-02,NEI:446001\,Research Projects,2014,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,07,039318308,US,TUFTS UNIVERSITY BOSTON,MA,02111,"PUBLIC HEALTH RELEVANCE:  Retinopathy of prematurity (ROP) is a disorder of the developing eye that occurs in approximately 15,000 preterm newborns per year in the US and leads to blindness in about 500. Our project will contribute directly to an improved understanding of the causation of ROP by providing novel data on inflammation-associated substances circulating in the preterm baby's blood and their associations with ROP occurrence and progression, thereby elucidating potential target mechanisms for prevention and intervention.                ",2311243;,"DAMMANN, OLAF;","REDFORD, MARYANN ",02/01/2013,01/31/2017,angiogenesis;Bacteriology;base;Biological Markers;Birth;Blindness;Blood;Blood specimen;Brain;Cerebrum;Cohort Studies;Data;Data Analyses;Databases;design;Disease;Epidemiology;Erythropoiesis;Etiology;Exposure to;Eye;Funding;Gestational Age;Goals;Histologic;Histology;Immune;improved;Infant;Inflammation;Intestines;Knowledge;Measurement;Measures;member;Modeling;Neonatal;Newborn Infant;novel;Organism;Outcome;Oxidative Stress;Oxygen;Pathogenesis;Pattern;Perinatal;Placenta;Play;postnatal;Pre-Eclampsia;Pregnancy;pregnancy disorder;Premature Infant;Prevention;Prevention strategy;Preventive Intervention;Proteins;public health relevance;Publishing;Relative Risks;Research;Research Personnel;Retinal Diseases;Retinopathy of Prematurity;Risk;Role;Sample Size;Sampling;Spottings;Techniques;Testing;treatment strategy;United States National Institutes of Health;white matter damage;Whole Blood;Work,Circulating Immune Biomarkers and Retinopathy of Prematurity,21820,ZEY1,Special Emphasis Panel,,,2,446001,
8607958,R01,EY,5,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY022111,SCHOOLS OF MEDICINE,PA-10-067,5R01EY022111-03,NEI:493088\,Research Projects,2014,NATIONAL EYE INSTITUTE,,OKLAHOMA CITY,UNITED STATES,OPHTHALMOLOGY,05,878648294,US,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,OK,731171213," Pathologic neovascularization occurs in a number of blinding diseases, including Diabetic Retinopathy and Age related Macular Degeneration, in which a common contributory factor is oxidative stress caused by an excessive rise of toxic molecules called Reactive Oxygen Species (ROS). Our data show that regenerative catalytic antioxidant cerium oxide nanoparticles destroy ROS, inhibit and reverse pathologic retinal neovascularization by modulating gene expression in the Very Low Density Lipoprotein Receptor null mouse. This project will determine: the longevity, potency and mechanism of action of the nanoceria;the effects of their combinatorial use with an inducer of antioxidant enzymes;and most likely will produce data which supports the therapeutic used of these particles to prolong vision and improve the quality of life for patients with these diseases.         ",1879574;,"MCGINNIS, JAMES FRANCIS;","SHEN, GRACE L",02/01/2012,01/31/2016,Acute;Age related macular degeneration;angiogenesis;Animals;Antioxidants;base;Basic Science;Blindness;Blood;Blood Vessels;Cells;Cerium;cerium oxide nanoparticle;Chronic;Clinical Research;combinatorial;Confocal Microscopy;cost;Coupled;Data;Development;Diabetic Retinopathy;Disease;Economic Burden;Effectiveness;Electroretinography;Enzymes;Epithelial;Extravasation;Eye diseases;Gene Expression;Gene Proteins;Genes;Goals;Health;Hypoxia;improved;in vivo;Inflammation;inherited retinal degeneration;Intercellular Junctions;Knockout Mice;Knowledge;Lesion;Liquid substance;Longevity;Longitudinal Studies;Macular degeneration;Mass Spectrum Analysis;Mus;neovascular;neovascularization;Nuclear;Optical Coherence Tomography;Outcome;Oxidative Stress;particle;Pathologic;Pathologic Neovascularization;Pathology;Patients;Phase;Photoreceptors;Plasma;prevent;Production;proliferative diabetic retinopathy;protein structure;Publishing;Quality of life;Reactive Oxygen Species;regenerative;Research;research study;Retina;Retinal;Retinal Degeneration;Retinal Diseases;Retinal Edemas;Retinal Neovascularization;Retinal Pigments;Structure of retinal pigment epithelium;Sulforaphane;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Uses;Thick;Time;Vascular Endothelial Growth Factors;Vision;VLDL receptor;Western Blotting;Work,Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants,22111,BDPE,Biology and Diseases of the Posterior Eye,,,3,493088,
8605188,R01,EY,5,N,02/04/2014,02/01/2014,01/31/2015,867,R01EY022238,SCHOOLS OF MEDICINE,PA-10-067,5R01EY022238-03,NEI:563117\,Research Projects,2014,NATIONAL EYE INSTITUTE,,LEXINGTON,UNITED STATES,OPHTHALMOLOGY,06,939017877,US,UNIVERSITY OF KENTUCKY,KY,405060057," Narrative There is no FDA-approved treatment for the one million Americans with geographic atrophy (GA) or for the millions more who are at risk of developing GA. We recently discovered an enzymatic deficiency that leads to accumulation of toxic RNA molecules in the eyes of patients with GA. The goal of this project is to understand how this newly discovered pathway causes GA, and to test drugs that will be suitable for entry into clinical trials.",2446639;,"AMBATI, JAYAKRISHNA;","SHEN, GRACE L",02/01/2012,01/31/2017,Accounting;Affect;Age related macular degeneration;American;Animal Model;Antisense Oligonucleotides;base;Biochemical;Biogenesis;Blindness;Blood Vessels;Cell Death;Cell Survival;Cells;Cellular Stress;Characteristics;Choroidal Neovascularization;Clinical Trials;cytotoxic;cytotoxicity;Data;Developed Countries;Development;Diagnosis;DICER1 gene;Disease;Down-Regulation;drug testing;Economics;effective therapy;Elements;Etiology;Eye;FDA approved;Functional disorder;geographic atrophy;Goals;Health;Health Expenditures;Human;Human Pathology;Immune;immune activation;improved;Inflammatory;insight;Lead;Link;Maps;Mediator of activation protein;member;MicroRNAs;Modeling;Molecular;Molecular Target;Nature;nonhuman primate;novel;novel therapeutics;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Prevalence;prevent;Process;Productivity;programs;Proteins;Regulation;response;Retina;Retinal Diseases;Retrotransposon;Ribonucleases;Risk;RNA;RNA Splicing;Signal Pathway;spatiotemporal;Stimulus;Strategic Planning;Structure of retinal pigment epithelium;Testing;Therapeutic;Toll-like receptors;Transcript;Translating;Variant;Vision,Functional studies of DICER1 and Alu RNA in geographic atrophy,22238,BDPE,Biology and Diseases of the Posterior Eye,,,3,563117,
8607551,R01,GM,5,N,02/05/2014,02/01/2014,01/31/2015,859,R01GM030301,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01GM030301-33,NIGMS:414391\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PROVIDENCE,UNITED STATES,CHEMISTRY,01,001785542,US,BROWN UNIVERSITY,RI,02912," Terpenoid metabolites, the largest known group of natural products, include many medicinally important substances (taxol for treatment of cancer, artemisin for malaria) as well as substances harmful to human and animal health (trichothecane fungal toxins), in addition to numerous antibiotics, fungal virulence factors, immunosuppresants, neurotoxins, flavor and odor constituents, and natural plant defense compounds. Studies of the biosynthesis of these compounds by bacteria and fungi can not only lead to an understanding of fundamental metabolic pathways, but facilitate the development of practical tools for the generation of new medicinal agents or for prevention of the formation of toxic or otherwise undesirable metabolites by pathogenic or environmental microorganisms. Moreover, mining of genomic information to biochemically characterize cryptic genes of unknown function will lead to fundamental new biological insights into the central issue of modern molecular biochemistry, the relationship between protein sequence, structure, and function.            ",1897706;,"CANE, DAVID E;","GERRATANA, BARBARA ",01/01/1982,01/31/2016,Actinobacteria class;Alcohols;Amino Acid Sequence;Anabolism;Animals;Antibiotics;Antimalarials;antitumor agent;Aquaculture;arenaemycin E;artemisin;artemisinine;Artemisinins;Bacteria;base;Binding Proteins;Biochemical;Biochemical Reaction;Biochemistry;Bioinformatics;Biological;Biological Factors;Biological Models;cancer therapy;Catalysis;Cell Respiration;Characteristics;Crystallography;Cyanobacterium;Cyclization;Cytochromes;Databases;Development;Dioxygenases;drinking water;Enzymatic Biochemistry;Flavins;Flavoring;fungus;Gene Expression;Generations;Genes;Genomics;geosmin;Health;Hormones;Human;Hydrocarbons;In Vitro;in vivo;Individual;insight;Investigation;isoprenoid;Lead;liverwort;Logic;Malaria;Marines;Medicine;Metabolic;Metabolic Pathway;Metabolism;microbial;microbial genome;microorganism;Mining;Mixed Function Oxygenases;Molecular;Molecular Genetics;Mycotoxins;Neurotoxins;novel;Nucleotides;Odors;Operon;Oxygenases;Paclitaxel;Pathway interactions;Peptide Sequence Determination;phytoalexin;phytoalexins;Plant Growth Regulators;Plants;Play;Prevention;Process;protein structure;Proteins;public drinking;Reaction;Regulation;Research;Role;Site-Directed Mutagenesis;Soil;Specificity;Staging;structural biology;Structural Protein;Structure;Taste Perception;terpene synthase;Terpenes;Terpenoid Biosynthesis Pathway;tool;Trichothecenes;Virulence;Virulence Factors;Water Supply,Biosynthesis of Microbial Isoprenoids,30301,MSFE,Macromolecular Structure and Function E Study Section,,,33,414391,
8601707,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM052470,,PA-10-067,5R01GM052470-19,NIGMS:486300\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,,12,064931884,US,SLOAN-KETTERING INST CAN RES,NY,10065," mRNA capping enzymes are attractive targets for anti-infective drug discovery in light of the stark differences in the structures, mechanisms, and pharmacological sensitivities of the capping apparatus in humans versus fungal and protozoan pathogens. CTD phosphorylation dynamics orchestrate eukaryal gene expression. Two of the enzymes we study that modulate CTD structure are implicated in human pathology. A partial deficiency of human CTD phosphatase Fcp1 is associated with the autosomal recessive developmental disorder characterized by cataracts, facial dysmorphism, and peripheral neuropathy. Cdk9 CTD kinase activity is critical for HIV replication and Cdk9 dysregulation is associated with cardiac hypertrophy.            ",1858903;,"SHUMAN, STEWART H;","BENDER, MICHAEL T.",05/01/1995,01/31/2016,Affect;Anti-Infective Agents;Binding (Molecular Function);Biochemical;Biochemical Reaction;Bypass;Catalysis;Catalytic Domain;Cataract;Chromatin Structure;cis trans isomerization;Code;combinatorial;Complex;Consensus;Coupled;Cues;developmental disease/disorder;Diphosphates;Dissection;drug discovery;Elongation Factor;Ensure;Enzymes;Face;Fission Yeast;Funding;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Transcription;genome-wide;Goals;Growth;Guanine;guanylyltransferase;Heart Hypertrophy;HIV;Human;Human Pathology;In Vitro;in vivo;inorganic phosphate;insight;Light;Messenger RNA;Methyltransferase;Molecular Profiling;mRNA guanylyltransferase;mRNA Precursor;mRNA Stability;mutant;Mutation;N-terminal;pathogen;Pathology;Pathway interactions;Peripheral Nervous System Diseases;Phenotype;Phosphoproteins;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Plastics;Play;Polyadenylation;Polymerase;Positioning Attribute;Process;Promotor (Genetics);Protein Dephosphorylation;Protein Kinase;Protein phosphatase;Proteins;Reaction;Reading;receptor;Recruitment Activity;RNA;RNA Polymerase II;RNA polymerase II largest subunit;RNA Splicing;RNA triphosphatase;Role;Route;Serine;Site;Specific qualifier value;Specificity;Staging;Structure;Substrate Specificity;Transcript;Transcription Elongation;Translations;tripolyphosphate;yeast genetics,mRNA Capping Enzymes,52470,MGB,Molecular Genetics B Study Section,,,19,486300,
8602835,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM052872,SCHOOLS OF MEDICINE,PA-10-067,5R01GM052872-15,NIGMS:295793\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,OTHER BASIC SCIENCES,52,804355790,US,UNIVERSITY OF CALIFORNIA SAN DIEGO,CA,920930934,,1862334;,"FU, XIANG-DONG;","BENDER, MICHAEL T.",05/01/1996,01/31/2016,acrosome stabilizing factor;Address;Alternative Splicing;Animal Model;base;Biochemical;Biological Process;Cancer Biology;Catalysis;cell growth;Cell model;Cell Nucleus;cell transformation;Cells;Complement;Cytoplasm;Development;Dissection;EGF gene;Enzymatic Biochemistry;Epigenetic Process;Event;Feedback;Funding;Genome Stability;high throughput technology;Human;insight;Knock-out;Knockout Mice;Malignant Neoplasms;Mammalian Cell;Mediating;Metabolism;Molecular;Molecular Chaperones;Mus;new technology;novel;Pathway interactions;Pharmaceutical Preparations;Phase;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Process;Property;Protein Kinase;Proteins;Regulation;Reporter;research study;Resistance;response;RNA;RNA Splicing;Role;RS protein;Series;Signal Transduction;Signal Transduction Pathway;Structure;Substrate Specificity;Technology;Testing;Transducers;tumorigenesis,Regulation of RNA metabolism and cell growth control by SR protein kinases,52872,MGC,Molecular Genetics C Study Section,,,15,295793,
8606856,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM054839,SCHOOLS OF MEDICINE,PA-10-067,5R01GM054839-16,NIGMS:282647\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,03,043207562,US,YALE UNIVERSITY,CT,065208047, The ribosome is responsible for making all proteins in all living things. It is a primary antibiotic target and the information gained in this research progra could lead to improved drugs for combating disease.                ,1883004;,"STROBEL, SCOTT A;","PREUSCH, PETER C.",08/01/1996,01/31/2016,Acids;Active Sites;Address;Affect;Affinity;Alcohols;Amines;Amino Acids;amino group;analog;Antibiotics;base;Binding (Molecular Function);Biochemical;Biochemical Genetics;Catalysis;Cells;Charge;Chemicals;Chemistry;Cleaved cell;cofactor;combat;Complex;Data;deprotonation;Disease;endonuclease;endoribonuclease;Endoribonucleases;environmental change;Enzymatic Biochemistry;Family;Fluorescence Anisotropy;functional group;Genetic Screening;Goals;Hydrogen Bonding;Hydrolysis;improved;Individual;inhibitor/antagonist;Isotopes;Kinetics;Label;Lead;Left;Length;Life;Measurement;Measures;Messenger RNA;Modification;mutant;Mutation;Nature;novel;overexpression;Peptides;peptidyl-tRNA;Peptidyltransferase;Pharmaceutical Preparations;Play;polymerization;Protein Biosynthesis;Proteins;protonation;Protons;Reaction;Relative (related person);release factor;Research;Resistance;response;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;Role;Scheme;Series;Site;Solutions;Structure;Testing;Thermodynamics;Toxin;Transfer RNA;Translating;Translations;Water,"Mechanisms of ribosomal reactions: peptide bond formation, peptide release and mR",54839,MSFE,Macromolecular Structure and Function E Study Section,,,16,282647,
8598882,R01,GM,5,N,02/06/2014,01/01/2014,12/31/2014,859,R01GM058540,SCHOOLS OF MEDICINE,PA-10-067,5R01GM058540-12,NIGMS:302400\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,GENETICS,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104," Problems with tube development or maintenance cause birth defects such as spina bifida and many common diseases such as kidney disease, heart disease and stroke.  These studies investigate how tubes develop and are maintained, with a special emphasis on the tiniest tubes in our bodies. Understanding these mechanisms will help in the design of therapies to prevent or treat tube-related disease.                   ",6369052;,"SUNDARAM, MEERA VEDAVALLI;","HOODBHOY, TANYA ",04/01/2000,12/31/2015,Actomyosin;Address;Adhesives;Anatomy;Animal Model;Apical;Behavior;Biology;Brain;Caenorhabditis elegans;Caliber;capillary bed;Cell Communication;cell fate specification;Cell surface;Cells;Complex;Congenital Abnormality;Cytoskeletal Modeling;Defect;Development;Disease;Down-Regulation;Duct (organ) structure;EGF gene;Epithelial;epithelial to mesenchymal transition;Extracellular Matrix;Family;Genes;Genetic;Genetic Screening;Genetic screening method;Health;Heart Diseases;Human;Image;in vivo;insight;Integral Membrane Protein;Kidney;Kidney Diseases;kidney vascular structure;Knowledge;Life;Link;Maintenance;Mammals;Mediating;Molecular;Morphogenesis;mutant;neuroblast;Organ;overexpression;P-Cadherin;Pathway interactions;Pattern;prevent;Process;programs;Property;Proteins;Receptor Protein-Tyrosine Kinases;research study;Role;Shapes;Signal Transduction;Spinal Dysraphism;stroke;Structure;System;Tertiary Protein Structure;Testing;therapy design;Time;Tissues;Tube;Tubular formation;Tubulin;Vascular System;Withdrawal;Zona Pellucida,Ras signaling and tubulogenesis in the C. elegans excretory (renal) system,58540,DEV2,Development - 2 Study Section,,,12,302400,
8616072,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM064589,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01GM064589-13,NIGMS:242386\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MINNEAPOLIS,UNITED STATES,PHYSICS,05,555917996,US,UNIVERSITY OF MINNESOTA,MN,554552070, The goal of the project is the development of a spectroscopic method with the unique ability to quantify protein interactions inside living cells. Knowledge of proteins and their interactions is a prerequisite for the identification of the molecular mechanism underlying a disease and provides crucial information for rational drug design.            ,6986582;,"MUELLER, JOACHIM D;","LEWIS, CATHERINE D.",02/01/2002,01/31/2016,Accounting;Address;Area;base;Basic Science;Bifidobacterium longum BIF protein;Binding (Molecular Function);Binding Proteins;Biological;Biological Models;Cell membrane;Cell physiology;Cells;Cellular biology;Color;color detection;Complex;Computer software;Cytoplasm;Data;Development;Diffusion;Disease;Drug Design;drug development;Elements;Environment;Epidermal Growth Factor Receptor;Event;Exhibits;fighting;Fluorescence;fluorescence imaging;Fluorescence Resonance Energy Transfer;Gagging;Goals;Homo;In Vitro;in vivo;Kinetics;Knowledge;Label;Lateral;Lead;Life;Measurement;Measures;Membrane;Membrane Proteins;Methodology;Methods;Modeling;Molecular;novel;novel strategies;Optics;particle;Performance;Pharmacologic Substance;Photobleaching;Preclinical Drug Evaluation;Principal Investigator;Process;programs;Property;Protein Binding;protein complex;protein function;Proteins;Regulation;Research;research study;Resolution;Sampling;Scanning;Signal Transduction;single molecule;Sorting - Cell Movement;Spectrum Analysis;stoichiometry;Structure;submicron;System;Techniques;theories;Thick;tool;Transport Vesicles;Tsg101 protein;Vesicle;Viral;Work;Writing,In Vivo Fluorescence Fluctuation Spectroscopy,64589,ZRG1,Special Emphasis Panel,,,13,242386,
8605194,R01,GM,5,N,02/06/2014,02/01/2014,01/31/2015,859,R01GM073042,SCHOOLS OF MEDICINE,PA-10-067,5R01GM073042-10,NIGMS:292998\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DALLAS,UNITED STATES,PHARMACOLOGY,30,800771545,US,UT SOUTHWESTERN MEDICAL CENTER,TX,753909105,"PUBLIC HEALTH RELEVANCE: Huntington's disease (HD) is an incurable neurodegenerative disorder. HD is caused by expression of mutant Huntington (HTT) protein, and an ideal therapeutic strategy would inhibit mutant HTT protein while leaving the wild-type protein untouched. My laboratory has developed three chemical strategies for selectively inhibiting production of the mutant protein. We propose to optimize inhibitors and understand how they function.            ",1862146;,"COREY, DAVID R.;","FABIAN, MILES ",02/01/2005,01/31/2017,Affect;Alleles;Animal Model;Animals;Antisense Oligonucleotides;base;Biochemical;Biological Assay;Cells;chemical property;Chemicals;Clinical;Clinical Trials;Data;Degenerative Disorder;design;Development;Disease;DRPLA protein;Funding;Gene Expression;Gene Silencing;Generations;Genes;Genetic Polymorphism;Goals;Hereditary Disease;human Huntingtin protein;Huntington Disease;Huntington protein;inhibitor/antagonist;innovation;insight;Laboratories;Lead;Left;Machado-Joseph Disease;Mammalian Cell;Messenger RNA;MJD1 protein;molecular recognition;mutant;Mutation;myotonic dystrophy protein kinase;Neurodegenerative Disorders;novel;Nucleic Acids;Nucleotides;Oligonucleotides;Pathway interactions;Patients;Pharmaceutical Preparations;Population;Positioning Attribute;Production;Proteins;public health relevance;Repetitive Sequence;Research Personnel;RNA;RNA Interference;Role;SCA7 protein;Structure-Activity Relationship;System;Testing;Therapeutic;therapeutic development;Toxic effect;Trinucleotide Repeat Expansion;Trinucleotide Repeats,Allele-Selective Inhibitors for Expanded Trinucleotide Repeat Genes,73042,SBCA,Synthetic and Biological Chemistry A Study Section,,,10,292998,
8599471,R01,GM,5,N,02/03/2014,01/01/2014,12/31/2014,859,R01GM073990,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01GM073990-07,NIGMS:326959\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LAWRENCE,UNITED STATES,BIOLOGY,02,076248616,US,UNIVERSITY OF KANSAS LAWRENCE,KS,660457568, The proposed studies directly investigate the genetic architecture of complex traits.  Most chronic human diseases are complex traits and the dissection of genetic causes is a major research focus of the National Institutes of Health.  Our experiments on the model plant Mimulus guttatus provide relevant results and 'proof-of-concept'of genetic methods for future health-related research.                 ,1872213;,"KELLY, JOHN K;","ECKSTRAND, IRENE A.",05/01/2006,12/31/2015,Adult;Affect;Alleles;Alternative Splicing;Architecture;Area;base;Biology;Candidate Disease Gene;Chronic;Clinical;Code;cohort;Complex;Data;design;Development;Disease;Dissection;DNA;doctoral student;Equilibrium;Evolution;Family;Female;Fertility;fitness;Flowers;Fruit;Future;Gene Expression;Gene Frequency;Genes;Genetic;Genetic Polymorphism;Genetic screening method;Genomics;Genotype;Harvest;Health;Human;human disease;Hybrids;Immune;Inbreeding;Individual;Iron;Maps;Measurement;Measures;Methods;MicroRNAs;Mimulus;Modeling;Molecular;Molecular Biology;Monitor;Mutation;Natural Selections;novel;Organism;overexpression;Parents;Phenotype;Plant Leaves;Plant Model;Plants;Population;Population Genetics;Procedures;pyrosequencing;Quantitative Trait Loci;Research;Research Personnel;research study;RNA Splicing;Sampling;Seedling;Seeds;Site;Staging;Statistical Models;survivorship;Testing;Time;Tissues;Training;trait;Transcript;Transplantation;United States National Institutes of Health;Variant;Variation (Genetics),A Genomic Analysis of Complex Trait Variation in Mimulus,73990,GVE,Genetic Variation and Evolution Study Section,,,7,326959,
8588940,R01,GM,5,N,02/06/2014,12/01/2013,11/30/2014,859,R01GM074637,SCHOOLS OF MEDICINE,PA-10-067,5R01GM074637-08,NIGMS:318310\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,PHYSIOLOGY,48,046705849,US,UNIVERSITY OF CALIFORNIA-IRVINE,CA,926977600,"PUBLIC HEALTH RELEVANCE: An accurate first-principles algorithm for predicting the three-dimensional structure of membrane proteins from amino acid sequence would profoundly affect research on membrane proteins, which are major targets for therapeutic drugs. The project is guided by the idea that the keys to successful prediction are to understand the physical principles of membrane protein stability and the biological principles of membrane protein assembly. Our goal is to tighten the connection between the physical and biological principles as a basis for prediction algorithms.         ",1964913;,"WHITE, STEPHEN H.;","CHIN, JEAN ",03/01/2006,11/30/2014,Accounting;Affect;Algorithms;Amino Acid Sequence;Bacteria;base;Belief;Bioinformatics;Biological;biological research;Canis familiaris;Code;Collaborations;Complex;Defect;design;Development;Escherichia coli;Eukaryota;genome-wide;Goals;Hydrogen Bonding;Hydrophobicity;In Vitro;in vivo;insight;Laboratories;Lead;Lipid Bilayers;Lipids;Measurement;Mediating;Membrane;Membrane Proteins;Methanococcus;Molecular;molecular dynamics;mutant;Mutation;Organism;Pancreas;Pathway interactions;Peptide Hydrolases;Peptide Signal Sequences;Pharmaceutical Preparations;protein folding;protein function;Protein Secretion;Proteins;public health relevance;Quality Control;Research;research study;Signal Recognition Particle;Signal Transduction;System;therapeutic target;three dimensional structure,Membrane protein folding and assembly,74637,ZRG1,Special Emphasis Panel,,,8,318310,
8609042,R01,GM,5,N,02/05/2014,02/01/2014,01/31/2015,859,R01GM074692,SCHOOLS OF MEDICINE,PA-10-067,5R01GM074692-08,NIGMS:251756\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,OKLAHOMA CITY,UNITED STATES,BIOCHEMISTRY,05,878648294,US,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,OK,731171213,"This project will investigate the mechanism of how endosomal Rab proteins may control nerve growth factor (NGF) signal transduction and neuronal differentiation and survival. Preliminary studies suggest that endosomal Rab proteins play an important role in regulation of endocytosis, sorting, and retrograde trafficking of NGF in neurons, which is required for NGF signaling processes. The results may have significant impact on the development of diagnosis and therapeutics against neurodegenerative disorders such as Alzheimer's disease, Down syndrome, and hereditary sensory and autonomic neuropathy.",2100219;,"LI, GUANGPU;","DUNSMORE, SARAH ",09/25/2006,01/31/2016,Alzheimer's Disease;Apoptosis;autonomic neuropathy;Axon;base;Biochemical;Biogenesis;Biological Assay;cell body (neuron);Cell Differentiation process;cell growth regulation;Cell Survival;Cells;Characteristics;Chimera organism;computerized data processing;Data;Development;Diagnosis;Dominant-Negative Mutation;Down Syndrome;Early Endosome;Endocytosis;Endosomes;Eukaryota;Evolution;Family;Fluorescence Microscopy;Goals;Hereditary Sensory Neuropathy;Human;Immunoblot Analysis;Intracellular Membranes;Label;Lead;man;Mediating;member;Membrane Protein Traffic;Monitor;mutant;Mutation;Nerve Growth Factors;Neurites;Neurodegenerative Disorders;Neuronal Differentiation;neuronal survival;Neurons;NGFR Protein;novel;Organism;PC12 Cells;Phosphotransferases;Phylogenetic Analysis;Physiological;Play;Property;Proteins;Quantum Dots;rab GTP-Binding Proteins;Recruitment Activity;Regulation;research study;RNA Interference;Role;screening;Signal Transduction;Signal Transduction Pathway;Site-Directed Mutagenesis;Sorting - Cell Movement;Specific qualifier value;Specificity;Spinal Ganglia;Testing;Therapeutic;trafficking;Vertebrates;Yeasts,Structural and Functional Specificity of Rab GTPases,74692,MBPP,Membrane Biology and Protein Processing Study Section,,,8,251756,
8606466,R01,GM,5,N,02/06/2014,02/01/2014,01/31/2015,859,R01GM076562,SCHOOLS OF MEDICINE,PA-10-067,5R01GM076562-07,NIGMS:357067\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HERSHEY,UNITED STATES,BIOCHEMISTRY,15,129348186,US,PENNSYLVANIA STATE UNIVERSITY,PA,170330850,"  Our research is directed towards understanding the means by which cells control their growth, metabolism and development in response to available resources, external stresses and environmental cues. The information we generate in this study should be very valuable in understand growth control in eukaryotic cells, with particular impact on evaluating how cells adapt to aberrant internal and external cues in pathological conditions such as cancer and diabetes.            ",1940958;,"BROACH, JAMES R.;","REDDY, MICHAEL K.",04/01/2007,01/31/2016,Address;Adopted;Allosteric Regulation;Behavior;biological adaptation to stress;Calculi;Carbon;Catabolism;Cell Nucleus;Cell physiology;Cells;Chronic Disease;Complex;constriction;Cues;Cyclic AMP-Dependent Protein Kinases;detection of nutrient;Development;Diabetes Mellitus;Disease;Environment;environmental change;Environmental Hazards;Enzymes;Equilibrium;Eukaryotic Cell;Event;Future;Gene Expression Regulation;Genetic Transcription;genome wide association study;Growth;Hour;Human Biology;Individual;Knowledge;Lead;Light;lipid metabolism;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolism;nitrogen metabolism;Noise;Nutrient;Nutritional;Outcome;Pathway interactions;Pattern;Population;Post-Translational Protein Processing;Post-Translational Regulation;Process;programs;Property;Proteins;Pyruvate Kinase;ras Proteins;Regulation;Research;Resources;response;Role;Saccharomyces;Signal Pathway;Signal Transduction;Sirolimus;Stress;Testing;Time;transcription factor;Work;Yeasts,Ras and TOR signaling in yeast,76562,MIST,Molecular and Integrative Signal Transduction Study Section,,,7,357067,
8602836,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM078069,,PA-10-067,5R01GM078069-07,NIGMS:338283\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,,07,078200995,US,FRED HUTCHINSON CAN RES CTR,WA,981091024," All cells must inherit the right number of chromosomes every time they divide because the wrong number of chromosomes is a hallmark of cancer, birth defects, and other diseases related to problems in cell proliferation. We are therefore studying the process of chromosome partitioning to daughter cells when they divide to understand the basis for a number of human diseases.         ",1882250;,"BIGGINS, SUSAN;","CARTER, ANTHONY D.",09/15/2007,01/31/2016,Address;Aneuploidy;base;Behavior;Binding Proteins;Biochemical;Biochemical Genetics;Biological Process;Cell Cycle;Cell Cycle Regulation;Cell division;Cell Proliferation;Cells;Centromere;Chromatin;Chromatin Structure;Chromosome Segregation;Chromosomes;Congenital Abnormality;Coupling;Data;daughter cell;Defect;Deposition;design;Development;Disease;DNA;DNA Sequence;Ensure;Epigenetic Process;Euchromatin;Eukaryota;Excision;Foundations;Generations;Genetic;Genetic Transcription;Genome Stability;Genomic Instability;Genomics;Histone H3;Histones;human disease;in vivo;Inherited;insight;Kinetochores;Lead;Maintenance;Malignant Neoplasms;Mediating;Methods;Microtubules;Modeling;Monitor;Mutate;N-terminal;novel;Nucleosomes;Organism;Post-Translational Protein Processing;prevent;Process;Protein Binding;protein structure;Proteins;Proteolysis;Proteomics;Regulation;Role;Saccharomycetales;segregation;Sister;Structure;Tail;Techniques;Testing;Therapeutic Intervention;Time;tumor;Variant;Weight-Bearing state;Work;Yeasts,Regulation of Centromeric Chromatin,78069,CSRS,Cellular Signaling and Regulatory Systems Study Section,,,7,338283,
8609579,R01,GM,5,N,02/06/2014,02/01/2014,01/31/2015,859,R01GM080308,SCHOOLS OF ARTS AND SCIENCES,PA-11-260,5R01GM080308-07,NIGMS:334800\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW BRUNSWICK,UNITED STATES,CHEMISTRY,06,001912864,US,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,NJ,08901,"  Abl fusion proteins (such as Bcr-Abl) are deregulated and cause various hematopoietic malignancies, such as chronic myeloid leukemia (CML), childhood and adult acute lymphoblastic leukemia, epithelial cell malignancies as well as invasive growth of breast cancer cells. The use of small molecules as inhibitors of Abl kinase activity holds great promise for therapeutic purposes.            ",8035200;,"KALODIMOS, CHARALAMPOS;","WEHRLE, JANNA P.",03/01/2007,01/31/2016,abl Genes;Actins;Adaptor Signaling Protein;Adult Acute Lymphocytic Leukemia;base;Binding (Molecular Function);Binding Sites;Biological Process;Breast Cancer Cell;cell motility;Cell-Cell Adhesion;Cells;Childhood;Childhood Chronic Myelogenous Leukemia;Chimeric Proteins;Chromosomal translocation;Chronic Myeloid Leukemia;Data;design;Development;Disease;DNA Damage;Drug resistance;Epithelial Cells;Family;fascinate;fusion gene;Growth;Hematopoietic Neoplasms;Homeostasis;Human Genome;Indium;inhibitor/antagonist;insight;kinase inhibitor;Kinetics;Ligands;Malignant Neoplasms;Maps;Mediating;Methodology;Molecular Conformation;Monitor;Motion;mutant;Mutation;NMR Spectroscopy;novel;pathogen;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Physiological;Post-Translational Protein Processing;Preparation;Process;Property;Protein Binding Domain;Protein Kinase;Protein Tyrosine Kinase;Proteins;Regulation;Regulatory Element;Reporting;resistance mutation;Resolution;response;Sampling;Signal Transduction;small molecule;Structure;System;Therapeutic;Therapeutic Uses;Thermodynamics;Trans-Activation (Genetics),Mechanisms of autoinhibition and activation of the Abl kinase,80308,ZRG1,Special Emphasis Panel,,,7,334800,
8628132,R01,GM,5,N,02/07/2014,02/01/2014,01/31/2015,859,R01GM086587,SCHOOLS OF MEDICINE,PAR-09-218,5R01GM086587-06,NIGMS:507474\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,SOCIAL SCIENCES,18,009214214,US,STANFORD UNIVERSITY,CA,943056203,"PUBLIC HEALTH RELEVANCE: Collaborative Prot[unreadable]g[unreadable] is a software system that helps a burgeoning user community to cooperate in developing ontologies that enhance biomedical research and improve patient care. Collaborative Prot[unreadable]g[unreadable] supports scientists, clinician researchers, and workers in informatics to build ontologies to solve problems in data annotation, data integration, information retrieval, natural-language processing, electronic patient record systems, and decision support. The proposed research will develop data-driven methods to identify patterns in design, development, and use of ontologies, and will apply these methods to help us to build new technology that both facilitates the ontology-development process and makes ontology design more principled.            ",1858670;,"MUSEN, MARK A;","BRAZHNIK, PAUL ",03/01/2009,01/31/2017,Address;Applications Grants;Area;Attention;base;biomedical ontology;Biomedical Research;biomedical resource;biomedical scientist;Classification;Collaborations;Communities;Computer software;Computerized Patient Records;Computers;Consensus;craniofacial;Data;Data Analyses;data integration;Data Set;Decision Support Systems;design;Development;Engineering;experience;Future;Generations;Genes;Goals;Human;improved;Informatics;Information Retrieval;International;International Classification of Diseases;interoperability;Knowledge;Lead;Learning;Maintenance;malformation;Measures;Metadata;Methods;Modeling;Morphologic artifacts;National Cancer Institute;Natural Language Processing;NCI Thesaurus;new technology;novel;Ontology;open source;Parasites;Patient Care;Pattern;Phase;Problem Solving;Process;public health relevance;Recording of previous events;repository;Research;Research Personnel;Research Project Grants;Resources;Scientist;Software Design;Software Engineering;software systems;Specialist;System;Terminology;Testing;Thesauri;Time;tool;tool development;Traditional Medicine;Work,Collaborative Development of Biomedical Ontologies and Terminologies,86587,BDMA,Biodata Management and Analysis Study Section,,,6,507474,
8607963,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM092893,EARTH SCIENCES/RESOURCES,PA-07-070,5R01GM092893-05,NIGMS:226501\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLLEGE STATION,UNITED STATES,BIOCHEMISTRY,17,078592789,US,TEXAS A&M UNIVERSITY,TX,77845,"PUBLIC HEALTH RELEVANCE: Understanding the intricately intertwined signal transduction networks acting downstream of various host immune sensors could provide novel avenues to prevent and control infectious diseases. Given that plant cell-surface and intracellular immune sensors are most similar to Toll-like receptor and NOD-like receptor in mammals respectively, our research will have broad impact on the understanding of signaling mechanisms of animal innate immunity.         ",10021299;,"HE, PING;","DUNSMORE, SARAH ",04/01/2010,01/31/2015,Animals;Arabidopsis;Attenuated;base;Binding (Molecular Function);Biochemical;Biological Assay;Biological Models;Biological Process;Calcium;calcium-dependent protein kinase;Cell surface;Cells;Communicable Diseases;Complex;Data;Detection;Employee Strikes;Environment;Environmental Risk Factor;Event;Family;Family member;Gene Expression Profile;Gene Expression Regulation;Gene Family;Genetic;Genome;Genomics;Goals;Immune;Immune response;Immune system;Immunity;improved;Individual;Infection;Leucine-Rich Repeat;leucine-rich repeat protein;Life;Mammals;member;Microbe;Molecular;Natural Immunity;novel;Nucleotides;pathogen;Pathogen detection;Pattern;Pattern recognition receptor;Phosphotransferases;Plant Model;Plants;Play;prevent;public health relevance;receptor;Regulation;Research;Resources;Role;sensor;Signal Pathway;Signal Transduction;System;Temperature;Toll-like receptors;tool;Virulence;Work,Differential regulation of plant innate immunity,92893,MIST,Molecular and Integrative Signal Transduction Study Section,,,5,226501,
8602838,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM097171,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01GM097171-03,NIGMS:268470\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,BIOLOGY,18,009214214,US,STANFORD UNIVERSITY,CA,943056203," The subject of this project-the evolution of gene expression-is of great importance to biomedicine. For example, a general understanding of mechanisms of gene expression evolution could be applied to pathogens to help understand the rapid emergence of drug resistant strains and other evolutionary dynamics that occur at scales ranging from a single host infection to global epidemics. Indeed, one yeast strain we propose to study (YJM789) is pathogenic in immunocompromised humans. In addition, a deeper understanding of human gene expression evolution will be essential for elucidating the molecular mechanisms underlying human-specific phenotypes, including many disease phenotypes.            ",7120833;,"FRASER, HUNTER B;","ECKSTRAND, IRENE A.",02/05/2012,01/31/2016,Address;Affect;Anabolism;Animal Model;base;Base Pairing;Cataloging;Catalogs;Collection;Data;design;disease phenotype;Drosophila genus;Drug resistance;Engineering;Environment;Epidemic;Ergosterol;Evolution;fitness;Fruit;functional group;Gasterosteidae;Gene Expression;Gene Expression Regulation;Genes;genetic manipulation;Genetic Transcription;Genome;genome analysis;genome-wide;Human;Hybrids;Immunocompromised Host;Individual;Infection;innovation;Intuition;Life;Maps;Measures;Methods;Modeling;Molecular;Mutation;Nucleotides;pathogen;Pathway interactions;Phenotype;Play;Population Sizes;pressure;Processed Genes;Regulation;Regulator Genes;resistant strain;Resources;Rest;RNA Sequences;Role;Saccharomyces;Saccharomycetales;sample fixation;Scanning;Site;System;Testing;trait;Work;Yeasts,Yeast as a model for understanding gene expression adaptation,97171,GVE,Genetic Variation and Evolution Study Section,,,3,268470,
8606470,R01,GM,5,N,02/07/2014,02/01/2014,01/31/2015,859,R01GM097251,SCHOOLS OF MEDICINE,PA-10-067,5R01GM097251-03,NIGMS:246477\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,AURORA,UNITED STATES,BIOCHEMISTRY,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571," The proposed research is relevant to public health because it will develop new methods for understanding and interpreting vertebrate (and human) genomes, and for identifying genomic regions that are functionally important and thus relevant to phenotype and disease. The project is relevant to the NIH mission because it will provide methods for extracting information from comparative genomic data that will inform the structure and function of genomes, and how they relate to phenotypes of disease-related mutations in humans.         ",1928683;,"POLLOCK, DAVID D;","KRASNEWICH, DONNA M",04/13/2012,01/31/2016,Affect;Amino Acids;analytical method;base;comparative;comparative genomics;Data;Detection;Development;Didelphidae;directed evolution;Disease;disease phenotype;DNA Sequence Rearrangement;DNA Transposable Elements;Elements;Evolution;fitness;Gene Conversion;Genetic Recombination;Genome;genome-wide;genome-wide analysis;Genomics;Genotype;Goals;Human;Human Genome;improved;Knowledge;Lead;Methods;Mission;mitochondrial genome;Modeling;Molecular;Molecular Structure;Mutation;Nature;news;novel;Nucleotides;Open Reading Frames;Outcome;Pattern;Phenotype;Phylogenetic Analysis;Positioning Attribute;predictive modeling;Principal Investigator;Process;programs;Proteins;public health medicine (field);Recording of previous events;Repetitive Sequence;Research;Role;Sampling;Sequence Analysis;Shapes;Site;Speed (motion);Structure;Testing;Time;tool;United States National Institutes of Health;Variant;vertebrate genome;Work,Genome-wide mutation models to decipher function,97251,GVE,Genetic Variation and Evolution Study Section,,,3,246477,
8604715,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM097263,SCHOOLS OF VETERINARY MEDICINE,PA-10-067,5R01GM097263-03,NIGMS:260129\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ITHACA,UNITED STATES,OTHER BASIC SCIENCES,23,872612445,US,CORNELL UNIVERSITY,NY,148502820," Homologous recombination (HR) is a mechanism by which cells can efficiently repair DNA damage arising from various pathological processes. HR is also the major mechanism that ensures accurate segregation of maternal and paternal chromosomes during meiosis (the specialized cell division that gives rise to the gametes: eggs and sperm). Without efficient HR in this contact, spontaneous chromosome abnormalities can arise, which can result in serious human diseases such as Down syndrome, are exceptionally prevalent in the human population. Our laboratory seeks to understand the molecular events that regulate HR during gametogenesis and thereby to evaluate which pathways may contribute to the errors seen in human meiosis.            ",8148901;,"COHEN, PAULA ELAINE;","JANES, DANIEL E",04/05/2012,01/31/2016,Ablation;Address;Appearance;Applications Grants;Ataxia-Telangiectasia-Mutated protein kinase;Biological Assay;Cell division;Cells;Chromosome abnormality;Chromosomes;Data;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;Docking;Double Strand Break Repair;Down Syndrome;egg;endonuclease;Ensure;Event;Exhibits;Family;Female;Frequencies (time pattern);Gametogenesis;Genetic;Genetic Crossing Over;Genetic Recombination;Genome;Germ Cells;Heart;helicase;Homeostasis;homologous recombination;Human;human disease;Knock-out;Laboratories;male;Mammals;Mediating;Mediator of activation protein;Meiosis;Meiotic Prophase I;Meiotic Recombination;Mismatch Repair;MLH1 gene;Modeling;Molecular;Monitor;MSH4 gene;mutant;Mutant Strains Mice;Mutation;novel;Optic Chiasm;Organism;Orthologous Gene;Output;Pathologic Processes;Pathway interactions;Phosphorylation;Play;Population;prevent;Process;Prophase;protein function;Proteins;Proteomics;Recruitment Activity;Regulation;Residual state;Resolution;Role;scaffold;segregation;sex;Signal Transduction;sperm cell;Spermatocytes;Spontaneous abortion;Staging;Sterility;Structure;Transgenic Organisms;Yeasts,Genetic Pathways Effecting Crossover Control and Meiotic Recombination in Mammals,97263,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",,,3,260129,
8606471,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM097355,SCHOOLS OF MEDICINE,PA-10-067,5R01GM097355-03,NIGMS:349786\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STONY BROOK,UNITED STATES,GENETICS,01,804878247,US,STATE UNIVERSITY NEW YORK STONY BROOK,NY,11794," The phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases generating various phospholipids that are critical signaling molecules and control a wide variety of biological processes including autophagy. Both PI3Ks and autophagy are involved in many pathological conditions including degenerative diseases and malignancies. Our study is designed to uncover the physiological roles and molecular mechanisms of PI3Ks in autophagy regulation, and will help with the understanding of the etiology of numerous human diseases as well as with the development of approaches targeting PI3Ks in treating human diseases such as cancer.           ",7032790;,"ZONG, WEI-XING;","MAAS, STEFAN ",04/13/2012,01/31/2016,"1-Phosphatidylinositol 3-Kinase;Afferent Neurons;Autophagocytosis;Autophagosome;base;Biological;Biological Process;Bypass;Catalytic Domain;Cell Culture Techniques;Cell physiology;Cells;Complex;Data;Degenerative Disorder;deprivation;design;Development;essential phospholipids;Etiology;Generations;Genes;GTPase-Activating Proteins;Heart;Homeostasis;human disease;human FRAP1 protein;hydroxyl group;in vivo;Knock-out;Knockout Mice;Lipids;Liver;Lysosomes;Malignant Neoplasms;Mammals;Mediating;member;Membrane;Membrane Protein Traffic;Metabolic;Metabolism;Molecular;Monomeric GTP-Binding Proteins;mTOR Signaling Pathway;novel;Nutrient;Pathway interactions;phosphatidylinositol phosphate, PtdIns(4,5)P2;Phosphatidylinositols;Phospholipids;Phosphotransferases;Physiological;Play;Process;Production;Protein Isoforms;Proteins;Proto-Oncogene Proteins c-akt;Regulation;Reporting;response;Role;scaffold;sensor;Sensory;Sequence Homology;Signal Pathway;Signal Transduction;Signaling Molecule;Substrate Specificity;Testing;Tissues;uptake;Vps34 Phosphatidylinositol 3 Kinase;Yeasts",Phosphatidylinositol 3-kinases and Autophagy,97355,CSRS,Cellular Signaling and Regulatory Systems Study Section,,,3,349786,
8643261,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM098394,SCHOOLS OF ARTS AND SCIENCES,PA-12-270,5R01GM098394-04,NIGMS:220057\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,TOLEDO,UNITED STATES,BIOLOGY,09,051623734,US,UNIVERSITY OF TOLEDO,OH,436063390," Centrosomes, which are composed of a pair of centrioles surrounded by an amorphous protein network of pericentriolar material (PCM), are fundamental cellular components that are critical for many cellular functions. Indeed, defects in centrosomal function are associated with multiple developmental disorders, male infertility, and various forms of cancer. Although much is known about centrosomal structure, the mechanism of PCM formation and assembly around the centrioles remains a mystery.         ",6915201;,"AVIDOR-REISS, TOMER;","GINDHART, JOSEPH G",02/01/2012,01/31/2017,Adult;Affect;Animal Model;Animals;Attention;Bardet-Biedl Syndrome;base;Binding (Molecular Function);Binding Sites;Biochemical;Biochemistry;Biogenesis;Biological Assay;biological systems;brain size;cancer type;Cell division;Cell physiology;Cells;Centrioles;Centrosome;Characteristics;Cilia;cilium biogenesis;Complex;Cystic Kidney Diseases;Cytosol;Data;Defect;Development;developmental disease/disorder;Diagnostic;Disease;Drosophila genus;Drosophila melanogaster;Embryo;Eukaryota;experience;fly;Generations;Genetic;Goals;Guanosine Triphosphate;Health;Human;In Vitro;in vivo;Individual;interdisciplinary approach;Left;Male Infertility;Malignant Neoplasms;Mediating;Methods;Microcephaly;Microtubules;mutant;Mutation;Neurons;Organelles;Organism;Patients;Positioning Attribute;Process;protein complex;protein function;Proteins;Recruitment Activity;Regulation;research study;Role;Shapes;Source;Structure;Testing;Time;tool;Tubulin;Tubulin Interaction;Work,The Mechanism of Pericentriolar Material Assembly During Centrosome Biogenesis,98394,CSRS,Cellular Signaling and Regulatory Systems Study Section,,,4,220057,
8608548,R01,GM,5,N,02/04/2014,02/01/2014,01/31/2015,859,R01GM099535,SCHOOLS OF ARTS AND SCIENCES,RFA-GM-12-001,5R01GM099535-03,NIGMS:369000\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PASADENA,UNITED STATES,NONE,29,009584210,US,CALIFORNIA INSTITUTE OF TECHNOLOGY,CA,91125," The importance of the microbiota to vital biological processes in humans is indisputable, and changes in the microbiota are associated with numerous diseases. This project will examine the molecular mechanisms by which an important class of human commensal bacteria establish and maintain long-term gut colonization. A molecular understanding for how complex microbiotas are shaped during health may be critical in future therapeutic approaches for human diseases.                ",8630548;,"MAZMANIAN, SARKIS K;","SLEDJESKI, DARREN D.",02/01/2012,01/31/2016,Address;Anatomy;Animals;Bacteria;Bacteroides;Bacteroides fragilis;base;Base Sequence;Biochemical Genetics;Biological Process;Biology;Birth;Cataloging;Catalogs;commensal microbes;Communities;Complex;Data;Development;Disease;Disease model;DNA Sequence;Ecology;Ecosystem;Evolution;Fingerprint;Funding;Funding Opportunities;Future;Gastrointestinal tract structure;Gene Deletion;Genes;Genetic;genetic manipulation;Genetic Screening;Genome;Gnotobiotic;gut microbiota;Health;Human;human disease;Human Microbiome;Immune system;in vivo;innovation;Intestines;Investigation;Laboratory culture;Link;Location;Mammals;Mediating;member;Metagenomics;Microbe;microbial;microbial colonization;microbial community;microbial host;microorganism;Microscopic;Molecular;Mono-S;Mucous Membrane;mutant;Names;novel;Organism;pathogen;Pattern;Population;Positioning Attribute;Process;Research Project Grants;Resistance;Shapes;Sterility;Surface;Symbiosis;System;Techniques;Testing;Therapeutic;Tissues;United States National Institutes of Health;Virulence Factors;Work,Molecular Mechanisms that Shape Gut Microbial Communities,99535,ZGM1,Special Emphasis Panel,,,3,369000,
8610930,R01,GM,5,N,02/04/2014,02/01/2014,01/31/2015,859,R01GM099825,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01GM099825-03,NIGMS:280939\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,BIOLOGY,37,072933393,US,UNIVERSITY OF SOUTHERN CALIFORNIA,CA,900899235," The ATR-Chk1 signal transduction pathway play a critical role in maintaining genome stability and in preventing cells from accumulating mutations and thereby becoming cancerous. A thorough understanding of ATR-Chk1 function and mechanism is therefore crucial for a more complete understanding of cancer biology. This project will address ATR-Chk1 mechanism and function in a model organism, the round worm C. elegans, with an emphasis placed on novel functions for ATR-Chk1 during embryonic development and in formation of reproductive germ cells.            ",6801836;,"MICHAEL, MATTHEW;","HAMLET, MICHELLE R",02/01/2012,01/31/2016,Address;Animal Model;Animals;ATM activation;ATM function;ATM Signaling Pathway;attenuation;base;Biochemical;biological adaptation to stress;Biological Assay;Biology;Caenorhabditis elegans;Cancer Biology;Cancerous;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Cycle Regulation;Cell Death;Cell division;Cell Line;Cell Proliferation;cell type;Cells;Chromosomes;Complex;Cultured Cells;Data;Development;DNA biosynthesis;DNA Damage;DNA Repair Pathway;egg;Embryo;embryo stage 2;Embryonic Development;Eukaryotic Cell;Event;Failure (biologic function);feeding;Fission Yeast;Foundations;functional genomics;Future;Generations;genetic analysis;Genome;Genome Stability;Germ Cells;Germ Lines;Goals;hatching;Human;human stem cells;human tissue;insight;Killings;Knowledge;KRP protein;Laboratories;Larva;Maintenance;Mitosis;Molecular;Monitor;Motion;Mutation;Nematoda;novel;Organism;Pathway interactions;Phosphatidylinositols;Play;Population;positional cloning;prevent;Process;programs;Prophase;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Rana (genus);Regulation;Relative (related person);Reproduction;reproductive;research study;response;RNA Interference;Role;S Phase;Saccharomycetales;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Specificity;Stem cells;Sterility;Stress;Structure;Structure of primordial sex cell;System;Testing;Time;tissue culture;TREX1 gene;Work,ATR-Chk1 signaling during embryonic and germ line development in C. elegans,99825,MGB,Molecular Genetics B Study Section,,,3,280939,
8607198,R01,GM,5,N,02/07/2014,02/01/2014,01/31/2015,859,R01GM101449,EARTH SCIENCES/RESOURCES,PA-10-067,5R01GM101449-03,NIGMS:241965\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LARAMIE,UNITED STATES,BIOCHEMISTRY,00,069690956,US,UNIVERSITY OF WYOMING,WY,82071," Biofilms are dense microbial mats that are medically important as they account for most microbial infections. Biofilm infections are difficult and expensive to treat because they are resistant to the host immune system and antimicrobial agents. This proposal seeks to investigate novel cell interactions in biofilms, which may advance our understanding of biofilms and consequently lead to improved intervention strategies.            ",6287787;,"WALL, DANIEL;","SLEDJESKI, DARREN D.",05/01/2012,01/31/2017,Accounting;Animal Model;Antibiotics;antimicrobial drug;base;Binding (Molecular Function);Biological;Biomedical Research;Cell Communication;Cell physiology;Cell Surface Receptors;Cells;Chimeric Proteins;Communication;Complement;Complex;Cooperative Behavior;Development;Eukaryotic Cell;Fruit;Genetic;Genetic Determinism;Gram-Negative Bacteria;Homeostasis;Immune system;improved;Infection;Intervention;Killings;Knowledge;Lead;Light;Lipoproteins;Liquid substance;Location;Mediating;Medical;Membrane;Membrane Fusion;Membrane Lipids;Microbe;microbial;Microbial Biofilms;microbial community;Modeling;Molecular;Movement;Myxococcales;Myxococcus xanthus;Nanotubes;novel;Pathway interactions;Phenotype;Play;Process;Proteins;Resistance;Resource Sharing;Role;Site;social;Social Interaction;Specificity;Structure;Surface;Swimming;System;Testing;Work,Protein exchange and self recognition in myxobacteria biofilms,101449,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,,3,241965,
8598916,R01,GM,5,N,02/06/2014,01/01/2014,12/31/2014,859,R01GM102362,SCHOOLS OF PHARMACY,PA-11-260,5R01GM102362-02,NIGMS:265050\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,PHARMACOLOGY,52,804355790,US,UNIVERSITY OF CALIFORNIA SAN DIEGO,CA,920930934,"PUBLIC HEALTH RELEVANCE:  A number of severe human diseases including Cockayne Syndrome, Ultraviolet-Sensitive Syndrome, Cerebro-Oculo-Facio-Skeletal Syndrome, Xeroderma Pigmentosum, and Trichothiodystrophy stem from defects in transcription-coupled DNA damage processing pathways. The goal of the proposed research is to elucidate the molecular mechanisms of transcription-coupled DNA damage processing pathways through a multidisciplinary approach, combining structural biology, chemical biology, biochemical, computational biology, and genetic methods. Deciphering the mechanisms of these processes will contribute to our understanding of the cause of premature aging, Cockayne Syndrome, and other related diseases and could be useful for developing potential clinical treatments.                ",9221954;,"WANG, DONG;","PREUSCH, PETER C.",01/01/2013,12/31/2017,Active Sites;Affect;ATP phosphohydrolase;base;Biochemical;Biochemical Genetics;Biochemistry;Biological Models;Biology;Biophysics;Bypass;C-terminal;Categories;Cell Death;Cells;Chemicals;Clinical Treatment;Cockayne Syndrome;Computational Biology;Coupled;Defect;design;Deuterium;Disease;DNA;DNA Damage;DNA lesion;DNA Repair;Ensure;environmental agent;Face;Fission Yeast;fluorophore;Gene Expression;Genetic;Genetic Transcription;Genome;Goals;Homologous Gene;Human;human disease;Hydrogen;Hydrogen Bonding;Individual;insight;interdisciplinary approach;Investigation;Kinetics;Maps;Mass Spectrum Analysis;Measures;Mediating;Methods;Molecular;molecular dynamics;Nature;novel therapeutics;Nucleic Acids;Nucleotides;Organism;Pathway interactions;Pattern;Polymerase;Precipitation;Premature aging syndrome;prevent;Process;protein B;protein protein interaction;Proteins;public health relevance;Recruitment Activity;Regulation;Research;Research Project Grants;response;RNA;RNA Polymerase II;Role;Scanning;sensor;Signal Transduction;Site;Site-Directed Mutagenesis;skeletal;Specific qualifier value;stem;structural biology;Surface;Syndrome;Tay syndrome;Testing;Transcription Elongation;transcription factor S-II;Transcription Process;Transcription-Coupled Repair;ultraviolet;X-Ray Crystallography;Yeasts,Molecular Mechanisms for DNA Damage Processing by Transcription Machinery,102362,MSFB,Macromolecular Structure and Function B Study Section,,,2,265050,
8594254,R01,GM,5,N,02/03/2014,01/01/2014,12/31/2014,859,R01GM103593,GRADUATE SCHOOLS,RFA-GM-13-001,5R01GM103593-02,NIGMS:305100\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,12,071037113,US,ROCKEFELLER UNIVERSITY,NY,100656399,"PUBLIC HEALTH RELEVANCE: The intestinal microbiota regulates host metabolism and immunity and is associated with various human diseases. While the gut microbiota is known to confer host resistance to invading pathogens, the mechanisms by which specific commensal bacteria confer protection against enteric pathogens have been difficult to elucidate due to the complex interactions between the host and its microbiota. This proposal describes the utilization of a Caenorhabditis elegans model system to investigate how specific commensal intestinal bacteria, such as Enterococcus faecium, can confer protection against gut pathogens such as Salmonella enterica. E. faecium is a normal member of the human intestinal microflora. Some strains are used as probiotics, but the specific mechanisms that enable to E. faecium colonize and protect various animals from infection are unknown. We demonstrate that E. faecium inhibition of Salmonella pathogenesis can be recapitulated in the C. elegans model. We will use this robust and efficient system to identify E. faecium factors that are required for protection of C. elegans from infection by employing candidate-based mutation analysis and unbiased genetic screening approaches. Imaging of bacterial distribution and dynamics during host colonization, along with complementary biochemical and genetic approached, will allow the characterization of identified E. faecium mutants. The E. faecium mutants characterized from these C. elegans studies will then be evaluated in mouse models of inflammation and bacterial infection to identify conserved mechanisms of host colonization and protection. These studies will reveal important mechanisms of commensal bacteria interactions with animal hosts and should guide the development of improved and tailored probiotics for the treatment of human diseases.                ",9076601;,"HANG, HOWARD C;","SLEDJESKI, DARREN D.",01/01/2013,12/31/2016,Animal Model;Animals;Antibiotic Resistance;Antibiotics;Attenuated;Bacteria;Bacterial Infections;base;Biochemical;Biochemical Genetics;Biological Models;Caenorhabditis elegans;Cleaved cell;commensal microbes;Complex;Development;Disease;Enteral;enteric pathogen;Enterococcus faecium;Environment;falls;Genetic;Genetic Screening;gut microbiota;Health;Host resistance;Human;human disease;Image;Immune system;Immunity;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammation;Inflammatory disease of the intestine;inhibitor/antagonist;Intestines;Invaded;Investigation;Mammals;Mediating;member;Metabolism;microbiome;Modeling;Modern Medicine;mouse model;Mus;mutant;Mutation Analysis;pathogen;Pathogenesis;Peptidoglycan;Population;prevent;Probiotics;public health relevance;Role;Salmonella;Salmonella enterica;Salmonella typhimurium;Signal Pathway;Study models;Symbiosis;System;Virulence,Elucidation of Commensal Bacteria Mechanisms Required for Host Protection,103593,ZGM1,Special Emphasis Panel,,,2,305100,
8606473,R01,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R01GM104071,ORGANIZED RESEARCH UNITS,PA-11-260,5R01GM104071-02,NIGMS:265050\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW BRUNSWICK,UNITED STATES,NONE,06,001912864,US,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,NJ,08901,"PUBLIC HEALTH RELEVANCE: Bacterial viruses, bacteriophages, and their bacterial hosts are locked in a never-ending arms race, the former evolving various strategies to overcome host defenses, the latter acquiring elaborate defense systems. The aim of this work is to study a newly discovered bacterial host defense system CRISPR that is distinct from all previously known defense systems and in many ways resembles gene silencing pathways of higher organisms. These studies will shed light on fascinating but presently unknown molecular mechanisms of CRISPR defense and will lead to better understanding of horizontal gene transfer, a phenomenon responsible, among other things, for the dangerous spread of antibiotic resistant-bacteria.            ",3052045;,"SEVERINOV, KONSTANTIN V;","REDDY, MICHAEL K.",02/01/2013,01/31/2017,Accounting;Address;Affect;Antibiotic Resistance;Appearance;Archaea;arm;Bacteria;Bacteriophage M13;Bacteriophages;base;Biochemical;Cessation of life;Cluster Analysis;Collaborations;Complex;crosslink;Development;Direct Repeats;Discrimination (Psychology);DNA;DNA Restriction Enzymes;DNA Restriction-Modification Enzymes;Engineered Gene;Enzymes;Epigenetic Process;Escherichia coli;Eubacterium;Evolution;fascinate;Gene Silencing;Gene Silencing Pathway;Genes;Genetic;Genetic Engineering;Horizontal Gene Transfer;Host Defense;Human;human BCAR1 protein;Immunity;In Vitro;in vivo;Infection;interest;Laboratories;Lead;Light;Lytic;mathematical model;Mediating;Methylation;Mobile Genetic Elements;Modeling;Modification;Molecular;Molecular Cloning;Molecular Genetics;Monitor;Mutation;novel;Organism;pathogen;Pathogenicity Island;Plasmids;Process;Prokaryotic Cells;protein complex;Proteins;public health relevance;Race;research study;response;RNA Binding;RNA Phages;Site;Small RNA;Staging;System;tool;Toxin;Viral;Viral Physiology;Virus;Work,The function of small RNA-based viral defense system in E. coli,104071,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,,2,265050,
8620670,R01,GM,5,N,02/05/2014,02/01/2014,01/31/2015,859,R01GM104530,SCHOOLS OF ARTS AND SCIENCES,PA-11-260,5R01GM104530-02,NIGMS:257119\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EVANSTON,UNITED STATES,PHYSICS,09,160079455,US,NORTHWESTERN UNIVERSITY,IL,602013149,"PUBLIC HEALTH RELEVANCE: We will develop methods for preparing cryogenic biological specimens, and for combining high resolution phase contrast imaging with x-ray fluorescence imaging of trace elements. We will develop these capabilities along with research into nanoparticle-based drugs and labeling agents, to realize the full potential of a new, first-of-its-kind instrument.                ",2422825;,"JACOBSEN, CHRIS JOHNSON;","SWAIN, AMY L",02/15/2013,01/31/2017,base;beamline;Biological;Biological Preservation;biological systems;Biomedical Research;blind;Breast;cancer therapy;Cell Culture Techniques;Cells;Cellular Structures;cryogenics;design;Development;Disease;DNA;Drug Formulations;Electron Microscope;Electrons;Elements;Fluorescence;fluorescence imaging;fluorescence microscope;Fluorescence Microscopy;follow-up;Freezing;Funding;Gadolinium;gadolinium oxide;Goals;Human;Image;imaging modality;instrument;Investments;Ions;Label;lens;Life;Light;Malignant Neoplasms;Measurement;member;Metals;Methods;Microscope;Microscopy;Microtomy;Mitochondria;Morphologic artifacts;N.I.H. Research Support;nanomaterials;nanoparticle;novel;operation;Optics;Organelles;Pharmaceutical Preparations;Phase;Photons;Preparation;programs;Proteins;Protocols documentation;public health relevance;Radiation;Research;research and development;Research Personnel;Research Project Grants;Resolution;Roentgen Rays;Role;Route;Sampling;Scanning;Source;Specimen;Synchrotrons;Thick;Time;Tissues;Titania;Titanium;Trace Elements;Trace metal;United States National Institutes of Health;Variant;Water;Work;Zinc Fingers,Cryo ptychography combined with x-ray fluorescence analysis of metals in cells,104530,EBIT,Enabling Bioanalytical and Imaging Technologies Study Section,,,2,257119,
8607045,R01,HD,5,N,02/04/2014,02/01/2014,01/31/2015,865,R01HD037109,SCHOOLS OF MEDICINE,PA-10-067,5R01HD037109-12,NICHD:283057\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,LUBBOCK,UNITED STATES,BIOCHEMISTRY,19,609980727,US,TEXAS TECH UNIVERSITY HEALTH SCIS CENTER,TX,794306271,"PUBLIC HEALTH RELEVANCE: The most heartbreaking of disorders can be infertility, when a couple fails to conceive after at least a year of attempts. We discovered a gene, CSTF2T, that can be a hidden cause of male infertility-hidden, because females missing this gene have normal fertility, while males have severe problems in sperm production. Using a variety of techniques, we want to learn the molecular causes of why sperm production fails in males missing the CSTF2T gene, to better understand how to assist these infertile couples.          ",1884548;,"MACDONALD, CLINTON C;","MOSS, STUART B.",09/27/1999,01/31/2016,Antibodies;base;Beryllium;Binding (Molecular Function);Binding Proteins;Biological Assay;C-terminal;Cell Culture Techniques;Cells;Chromosome Segregation;Chromosome Structures;Complement;Complementary DNA;Complex;Couples;crosslink;Cultured Cells;Data;Defect;Disease;DNA Transposable Elements;Elements;Essential Genes;Exons;Family;Female;Fertility;Fertilization;Gene Expression;Genes;Genetic;Genetic screening method;Genomics;Germ Cells;Grant;Hereditary Disease;Human;Human Genetics;Human Genome;Immunoprecipitation;in vivo;Individual;Infertility;Knockout Mice;Laboratory Study;Learning;Length;Luciferases;male;Male Infertility;Mediating;Meiosis;Messenger RNA;Metabolic;Metabolism;Molecular;mouse genome;mRNA Expression;mRNA Precursor;Mus;mutant;Names;Nuclear;paralogous gene;Patients;Phenotype;Physiological;Poly(A) Tail;Polyadenylation;Polyadenylation Pathway;Process;Production;Proteins;public health relevance;Reproduction;reproductive;Retroposon;Retrotransposition;Retrotransposon;RNA;RNA Recognition Motif;RNA-Binding Proteins;RNA-Directed DNA Polymerase;Role;Running;Signal Transduction;Site;Somatic Cell;sperm cell;Spermatids;Spermatogenesis;Techniques;Testing;Testis;Tissues;transcription factor;Transfection;Transgenic Mice;Transgenic Organisms;Variant;Wild Type Mouse,MRNA Processing in Reproduction and Fertilization,37109,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",,,12,283057,
8606225,R01,HD,5,N,02/04/2014,02/01/2014,01/31/2015,865,R01HD068290,SCHOOLS OF MEDICINE,PA-08-099,5R01HD068290-03,NICHD:439302\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,SAINT LOUIS,UNITED STATES,OTHER HEALTH PROFESSIONS,01,068552207,US,WASHINGTON UNIVERSITY,MO,631304862,"  Dose has emerged as a key factor promoting functional recovery after stroke. Currently, a lack of data on the dose-response relationship impedes progress in the field of stroke rehabilitation. This project will result in empirically-driven estimates indicating the dose of movement practice required to drive maximal improvements and how these estimates can be individually modified for people undergoing stroke rehabilitation. Our estimates will immediately impact translational and rehabilitation research as well as clinical practice.            ",2203689;,"LANG, CATHERINE E;","MICHEL, MARY E",02/01/2012,01/31/2016,Activities of Daily Living;Animal Model;Animals;base;Biological Assay;Biological Products;chronic stroke;clinical practice;Clinical Research;Data;design;Dose;Goals;Hemispatial Neglect;Human;Impairment;Individual;innovation;Intervention;Knowledge;Measurement;meetings;Mental Depression;Modeling;motor deficit;Movement;neuromechanism;Neurorehabilitation;Outcome;patient population;Pharmacologic Substance;Population;Positioning Attribute;Randomized;Recovery;Recovery of Function;Rehabilitation Research;Rehabilitation therapy;Research;response;Schedule;Severities;Stem cells;stroke;stroke rehabilitation;Testing;Training;Transcend;Translational Research;Translations;Upper Extremity;Work,Dose-Response of Movement Practice During Stroke Rehabilitation,68290,MRS,Musculoskeletal Rehabilitation Sciences Study Section,,,3,439302,
8605812,R01,HD,5,N,02/05/2014,02/01/2014,01/31/2015,865,R01HD069043,SCHOOLS OF MEDICINE,PA-10-067,5R01HD069043-03,NICHD:280563\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,KANSAS CITY,UNITED STATES,OBSTETRICS &GYNECOLOGY,03,016060860,US,UNIVERSITY OF KANSAS MEDICAL CENTER,KS,66160, Endometriosis is a significant disease in women of reproductive age. Understanding how the disease develops and identifying those factors which participate in the pathogenesis may allow for new treatments and diagnostic tools for this disease.         ,1964112;,"NOTHNICK, WARREN B;","PARROTT, ESTELLA C",03/06/2012,01/31/2017,Adverse effects;Affect;Age;autocrine;base;body system;bone health;Cell Proliferation;Cells;Chronic Disease;Clinical;Data;Development;Diagnosis;Diagnostic;Disease;Disease Marker;Disease model;Endometrial;endometriosis;Epithelial Cells;Event;Functional disorder;Gene Expression;Goals;Growth;High Prevalence;Implant;improved;Infertility;insight;Knowledge;Mediating;Menstrual cycle;MicroRNAs;MMP3 gene;Modeling;Molecular;Molecular Profiling;mouse model;Mus;novel;Outcome;Papio;paracrine;Pathogenesis;Pelvic Pain;Regulation;Regulator Genes;Replacement Therapy;Reporting;Repression;reproductive;Research;restoration;Role;Serum;Staging;Stromal Cells;Testing;Therapeutic;therapeutic target;Tissues;tool;Translations;Woman;Women's Health,The Role of miR-451 in Endometriosis Pathophysiology and Treatment,69043,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,,,3,280563,
8605462,R01,HD,5,N,02/04/2014,02/01/2014,01/31/2015,865,R01HD070647,,PA-10-067,5R01HD070647-03,NICHD:490616\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,PITTSBURGH,UNITED STATES,,14,119132785,US,MAGEE-WOMEN'S RES INST AND FOUNDATION,PA,152133180," Ovarian insufficiency adversely affects women's reproductive potential, psychosocial well being, bone mineralization, cardiovascular health and life span. We propose to determine genetic etiology of human ovarian failure through analyzing genomes of affected women and comparing them to appropriate controls. Identification of novel genetic markers for human ovarian insufficiency will help identify women at risk for increased medical morbidity and mortality as well as offer them interventions to preserve their reproductive options.           ",1929167;,"RAJKOVIC, ALEKSANDAR;","TAYMANS, SUSAN ",04/01/2012,01/31/2017,Accounting;Affect;Age;Animal Model;Animals;base;Basic Science;Biological Markers;Biological Preservation;body system;Cardiovascular Diseases;Cardiovascular system;Chromosomal translocation;Clinical;clinical practice;cohort;Counseling;Data;Development;Diagnosis;exome;exome sequencing;Fertility;FMR1;Follicle Stimulating Hormone Receptor;folliculogenesis;FOXO3A gene;Future;gene discovery;Genes;Genetic;Genetic Markers;Genetic Predisposition to Disease;Genetic screening method;Genome;genome database;genome wide association study;genome-wide;Genomics;Genotype;Gonadal structure;Guidelines;Health;Hospitals;Human;Infertility;interest;Intervention;Investigation;Karyotype;Knockout Mice;Laboratories;Longevity;Medical;Menopause;microdeletion;Morbidity - disease rate;Mortality Vital Statistics;Mutate;Mutation;mutation carrier;Mutation Detection;Mutation Spectra;novel;Oocytes;Osteoporosis;Ovarian;ovarian failure;Ovary;Pathologic;Pathology;Pathway interactions;Patients;Physiologic calcification;premature;Premature Ovarian Failure;Preservation Technique;Primordial Follicle;psychosocial;Recruitment Activity;reproductive;Resolution;Risk;Risk Assessment;Rodent;Secure;Technology;Testing;Transgenic Animals;Turner's Syndrome;Variant;Variation (Genetics);Woman;Work;X Chromosome,Genomic Basis of Premature Ovarian Insufficiency,70647,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,,,3,490616,
8605463,R01,HD,5,N,02/04/2014,02/01/2014,01/31/2015,865,R01HD072189,SCHOOLS OF MEDICINE,PA-10-067,5R01HD072189-03,NICHD:346612\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,PITTSBURGH,UNITED STATES,OBSTETRICS &GYNECOLOGY,14,004514360,US,UNIVERSITY OF PITTSBURGH,PA,15213," The understanding of the molecular bases underlying the decision of undifferentiated spermatogonia to proceed down the pathway of differentiation or to renew themselves is important because this is a key step in the process of spermatogenesis. To date, this step in the spermatogenic lineage has been investigated primarily to rodents, and studies of non-human primates are urgently needed.            ",6369035;,"PLANT, TONY M;","MOSS, STUART B.",04/06/2012,01/31/2017,Address;Adult;Animal Feed;base;Biology;Cell physiology;Cells;Cellular biology;Commit;comparative;Cues;Development;Diet;Endocrine;Environment;Experimental Models;Gene Expression;Gene Expression Profile;Genes;Germ;Germ Cells;Global Change;Goals;Gonadotropins;Human;human male;Immunohistochemistry;In Situ Hybridization;Infertility;insight;interest;Interruption;Knowledge;Lead;Macaca mulatta;male;Male Contraceptions;Male Contraceptive Agents;Microarray Analysis;Mitosis;Molecular;Molecular Biology;Monkeys;Mus;nonhuman primate;novel;Paracrine Communication;Pathway interactions;Primates;Process;Proliferating;Quantitative Reverse Transcriptase PCR;Research Personnel;Rodent;Role;self-renewal;sertoli cell;Signal Pathway;Signal Transduction;species difference;Spermatogenesis;Spermatogonia;Testis;tool;Transcript;transcriptome sequencing;Translating;Tretinoin;Undifferentiated;Vitamin A;Vitamin A Deficiency;Work,Molecular Bases Committing Primate Spermatogonia to a Pathway of Differentiation.,72189,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",,,3,346612,
8643816,R01,HD,5,N,02/04/2014,02/01/2014,01/31/2015,865,R01HD074560,SCHOOLS OF ARTS AND SCIENCES,PA-11-260,5R01HD074560-02,NICHD:496916\,Research Projects,2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,STORRS-MANSFIELD,UNITED STATES,PSYCHOLOGY,02,614209054,US,UNIVERSITY OF CONNECTICUT STORRS,CT,06269,"PUBLIC HEALTH RELEVANCE: Sexually transmitted infections are prevented when sex partners of infected patients are notified, diagnosed and treated. This intervention trial will tes a theory-driven risk reduction counseling intervention enhanced to improve partner notification. The results of this study will have direct implications for clinic-based HIV prevention.                 ",1891036;,"KALICHMAN, SETH C;","NEWCOMER, SUSAN ",04/01/2013,01/31/2018,Acquired Immunodeficiency Syndrome;Affect;Africa South of the Sahara;African;Age;AIDS prevention;AIDS/HIV problem;Area;arm;Attention;base;Behavioral;Blood Circulation;CD4 Positive T Lymphocytes;Cells;Cessation of life;Cities;Clinic;Clinic Visits;Communication;communication behavior;condoms;Contracts;Counseling;Diagnosis;Diagnostic;Educational aspects;Epidemic;Event;evidence base;Exercise;Exposure to;follow-up;Health;Health behavior change;Helper-Inducer T-Lymphocyte;high risk;HIV;HIV Infections;HIV risk;HIV Seropositivity;Home environment;Immune;improved;indexing;Infection;innovation;Intervention;intervention effect;Intervention Trial;Investigation;Laboratories;Life;macrophage;Measures;Mediating;Mediation;men;Modeling;Notification;Outcome;Participant;Partner Communications;Partner Notification;Patients;Population;post intervention;Prevalence;prevent;Preventive Intervention;primary outcome;protective behavior;Provider;public health relevance;Randomized;Randomized Clinical Trials;randomized trial;Recruitment Activity;Research;Research Design;Resources;Risk;Risk Reduction;secondary outcome;Services;sex risk;Sexual Partners;Sexually Transmitted Diseases;skills;skills training;social cognitive theory;South Africa;Southern Africa;Testing;theories;Time;transmission process;Woman,Enhanced STI/HIV Partner Notification in South Africa,74560,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,,2,496916,
8651508,R01,HG,5,N,02/07/2014,02/01/2014,01/31/2015,172,R01HG006851,BIOMED ENGR/COL ENGR/ENGR STA,PA-11-260,5R01HG006851-02,NHGRI:322234\,Research Projects,2014,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,MINNEAPOLIS,UNITED STATES,ENGINEERING (ALL TYPES),05,555917996,US,UNIVERSITY OF MINNESOTA,MN,554552070,"PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because it will improve the accuracy, analysis time, and cost of the devices required for large-scale analysis of human genomes and the genomes of pathogens, in particular those features that are not amenable to analysis by high throughput sequencing or microarrays. The proposed research is relevant to the mission of the NHGRI to develop and improve novel technologies for genome research.            ",7251811;,"DORFMAN, KEVIN D;","SCHLOSS, JEFFERY ",04/11/2013,01/31/2016,Address;Adopted;Attention;base;Behavior;Chromosome inversion;Collaborations;Communities;Complement;cost;Cost Analysis;Coupled;Coupling;Data;data acquisition;Detection;Development;Device Designs;Devices;DNA;DNA Sequence;DNA Sequence Rearrangement;Engineering;Equilibrium;Fluorescence;Fluorescence Microscopy;Generic Drugs;Genome;Genome Mappings;genome sequencing;Genomics;Goals;high throughput analysis;Human Genome;Immobilization;improved;Individual;Industry;innovation;Label;Laws;Lead;Length;Location;Malignant Neoplasms;Measurement;Measures;Methods;Mission;Modeling;nanochannel;nanofabrication;National Human Genome Research Institute;new technology;next generation;next generation sequencing;novel;pathogen;Population;predictive modeling;prevent;Protocols documentation;prototype;public health medicine (field);public health relevance;Reading;Research;research study;Resolution;Role;Sampling;Silicon Dioxide;Simulate;simulation;single molecule;Single Nucleotide Polymorphism;Speed (motion);Stretching;Surface;Techniques;Technology;Testing;theories;Time;tool;Variant;Video Microscopy;Width;Work,Dynamics of DNA Barcoding in Nanochannels,6851,ISD,Instrumentation and Systems Development Study Section,,,2,322234,
8643565,R01,HL,5,N,02/03/2014,01/01/2014,12/31/2014,837,R01HL016152,SCHOOLS OF MEDICINE,PA-07-070,5R01HL016152-38,NHLBI:298574\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,NONE,06,041387846,US,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,SC,29208,"PUBLIC HEALTH RELEVANCE: Human heart has great energetic needs because of its large workload (equivalent to pushing 1 ton the length of a football field per day);where the required energy supply is provided by mitochondria occupying ~30% of the cellular volume. Since cardiac contractility in normal and abnormal heart is mediated by cycling of Ca2+ in the cell, it is likely that Ca2+ signaling in the heart may also be the mechanism by which energy supply from the mitochondria is regulated. The nature of the signals that transmit information between the generation of energy supply per beat from the mitochondria and the Ca2+ released from the SR to meet the contractile needs of the myocyte is the subject of the proposed research in both healthy and diseased hearts.         ",1876628;,"MORAD, MARTIN;","KRULL, HOLLY ",09/01/1978,12/31/2014,"2,2,6,6-tetramethyl-4-piperidinol-N-oxyl;Abbreviations;Acidosis;Adult;Apoptosis;ATP phosphohydrolase;base;Caffeine;Carbonyl Cyanide m-Chlorophenyl Hydrazone;Cardiac;Cardiac Myocytes;Cardiomyopathies;Caveolins;Cells;Characteristics;Confocal Microscopy;Cytoskeletal Proteins;Dependence;Development;Dihydropyridine Receptors;Dyes;Dystrophin;Electrophysiology (science);Embryo;Energy Supply;extracellular;Family Felidae;Fluorescence;fluorescence imaging;Generations;Heart;Heart Atrium;Human;Hypoxia;Image;improved;Individual;infancy;inhibitor/antagonist;Inositol;Integrins;Isoproterenol;ITPR1 gene;Kinetics;Lactic Acidosis;Leigh Disease;Length;Liquid substance;Location;Manufactured football;Mechanics;Mediating;meetings;Membrane Potentials;Metabolic;Mitochondria;mitochondrial membrane;mitochondrial permeability transition pore;Molecular;Monitor;Mus;Muscle Cells;Myocardium;Myopathy;N-Methyl-D-Aspartate Receptors;Nature;Neonatal;Nitric Oxide;novel;Nuclear;Pathology;Peripheral;Physiologic pulse;Play;postnatal;pressure;Process;Production;Proteins;public health relevance;Rattus;Reactive Oxygen Species;receptor;Reducing Agents;Reperfusion Injury;Research;Resolution;response;rhod 2-AM;rhod-2;Role;Ryanodine Receptor Calcium Release Channel;Ryanodine Receptors;Sarcolemma;Sarcoplasmic Reticulum;sensor;Signal Pathway;Signal Transduction;Solutions;Source;Spatial Distribution;Staining method;Stains;Stimulus;Stress;Stretching;Structural Protein;Techniques;Testing;Time;tripolyphosphate;Ventricular;voltage clamp;Voltage-Dependent Anion Channel;Work;Workload",Electrophysiology of Neonatal and Adult Heart,16152,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,,38,298574,
8610340,R01,HL,5,N,02/03/2014,02/01/2014,01/31/2015,837,R01HL039006,SCHOOLS OF MEDICINE,PA-11-260,5R01HL039006-25,NHLBI:427451\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212,"PUBLIC HEALTH RELEVANCE: High blood pressure is an enormous health care burden in the United States, affecting one in three adults. It is a major cause of stroke, heart attack and kidne disease;however, the causes of hypertension remain poorly understood and treatment is not always successful. In our proposed studies, we will further define the inflammation that causes hypertension and develop new strategies to prevent this.            ",1862941;,"HARRISON, DAVID G;","REID, DIANE M.",08/01/1987,01/31/2018,adaptive immunity;adduct;Adoptive Transfer;Adult;Affect;Age-Years;Aldosterone;Angiotensin II;Animals;base;Blood Pressure;care burden;Catecholamines;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell physiology;Cells;Chronic;cytokine;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;Environment;Essential Hypertension;Etiology;Functional disorder;Funding;Healthcare;Human;human CYBA protein;Hypertension;Immune;Immune system;Immunity;immunogenicity;Inflammation;Inflammatory;Infusion procedures;insight;Interferon Type II;Interferons;Interleukin-17;Isoprostanes;ketoaldehyde;Kidney;kidney vascular structure;Laboratories;Lead;Lipid Peroxidation;Lysine;Mechanics;Methodology;mouse model;Mus;Myocardial Infarction;NADPH Oxidase;novel therapeutics;Organ;Pathway interactions;Peripheral;Phenotype;Play;Population;Positioning Attribute;prevent;Production;Proteins;public health relevance;Reactive Oxygen Species;Research;Research Personnel;research study;Role;Signal Transduction;Site;Sodium;Sodium Chloride;Stimulus;stroke;Superoxides;T-Cell Activation;T-Lymphocyte;Talents;Techniques;Testing;Tissues;United States;Vascular constriction (function);Work,"Immunity, Inflammation and Hypertension",39006,HM,Hypertension and Microcirculation Study Section,,,25,427451,
8617289,R01,HL,5,N,02/03/2014,02/01/2014,01/31/2015,837,R01HL052141,SCHOOLS OF MEDICINE,PA-11-260,5R01HL052141-17,NHLBI:369287\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,STANFORD,UNITED STATES,BIOLOGY,18,009214214,US,STANFORD UNIVERSITY,CA,943056203,PUBLIC HEALTH RELEVANCE:  This work will elucidate how the cellular organelles that generate energy to the heart contribute to cardiac injury after heart attack. Some of the pharmacological reagents that we will prepare may be useful also as drug leads for patients with heart attacks.            ,1878132;,"MOCHLY-ROSEN, DARIA;","WONG, RENEE P",04/05/1996,01/31/2017,Abbreviations;Address;Affect;aldehyde dehydrogenases;Aldehydes;Apoptosis;artery occlusion;Binding (Molecular Function);Calcium;Calsequestrin;Cardiac;Cardiac Myocytes;Cell Death;Cell physiology;Cellular biology;Clinical Trials;Cytoprotection;cytotoxic;design;Dynamin;Dynamin 2;Enzymes;Event;Excision;Family suidae;Funding;Glyceraldehyde-3-Phosphate Dehydrogenases;Grant;Health;Heart;Heart Diseases;heart metabolism;Hormones;Hour;Impairment;in vivo;inhibitor/antagonist;Injury;insight;Ischemia;Isoenzymes;Measures;Mediating;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;Molecular;Mus;Muscle Cells;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;Necrosis;novel;Organelles;Pathology;Patients;PDH kinase;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Phosphorylation;preconditioning;Preparation;prevent;Protein Kinase C;protein kinase C epsilon;Protein Kinase C Inhibitor;protein kinase C-delta;Proteins;public health relevance;Rattus;Reagent;Regulation;Reperfusion Injury;Reperfusion Therapy;Research;response;Role;Sarcoplasmic Reticulum;Site;Staging;Stream;Structure;Therapeutic Intervention;Work,Protein Kinase C Isozymes in Ischemic Heart,52141,MIM,Myocardial Ischemia and Metabolism Study Section,,,17,369287,
8605544,R01,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,R01HL095786,SCHOOLS OF MEDICINE,PA-07-070,5R01HL095786-05,NHLBI:326280\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLLEGE STATION,UNITED STATES,OTHER BASIC SCIENCES,17,835607441,US,TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR,TX,77845,"PUBLIC HEALTH RELEVANCE:  Chronic wounds elicit significant social and economic burdens;therefore, a complete understanding of these events is warranted. This proposal will significantly advance our understanding of how various physiological forces and biochemical signals initiate new blood vessel growth, which is a required step in wound healing. Such knowledge will ultimately aid to decrease the socio-economic burdens associated with aberrations or deficiencies in the process.         ",6840415;,"BAYLESS, KAYLA J;","REID, DIANE M.",02/01/2010,01/31/2015,Address;Adult;angiogenesis;Angiogenic Factor;Angiogenic Switch;base;Biochemical;Blood capillaries;Blood Vessels;Calpain;capillary;cell motility;Cells;Chronic;Cleaved cell;Communication;Cues;Dimensions;DNA Sequence Rearrangement;Economic Burden;Endothelial Cells;Environment;Equilibrium;Event;Exhibits;Future;Goals;Growth;Growth Factor;Human;human MMP14 protein;improved;In Vitro;in vivo;in vivo Model;Injury;innovation;insight;interdisciplinary approach;Intermediate Filament Proteins;Intermediate Filaments;intravital imaging;Invaded;Knowledge;Lipids;Mechanics;Membrane;Metalloproteases;MMP14 gene;Molecular;Monitor;Mus;novel;Organism;Peptide Hydrolases;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Population;Process;Production;Protein Isoforms;Proteins;Proteolysis;public health relevance;research study;response;shear stress;Signal Pathway;Signal Transduction;social;socioeconomics;Stimulus;Structure;System;three-dimensional modeling;Time;tissue regeneration;Tissues;Transgenic Mice;Vimentin;wound;Wound Healing;wound vascularization,Mechanisms of Angiogenic Switch Activation During Wound  Repair,95786,VCMB,Vascular Cell and Molecular Biology Study Section,,,5,326280,
8676898,R01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,837,R01HL098280,,PA-07-301,5R01HL098280-05,NHLBI:674769\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,07,073130411,US,MASSACHUSETTS GENERAL HOSPITAL,MA,02199," Given the mounting evidence in favor of early treatments for patients presenting with acute coronary syndromes, discovering sensitive and specific biomarkers that provide biochemical evidence of early myocardial injury could have a substantial positive impact on patient care. This project describes the application of a new metabolomics technology for biomarker discovery to address this clinical need.         ",1882933 (contact);6438352;,"GERSZTEN, ROBERT E (contact);SABATINE, MARC S;","APPLEBAUM-BOWDEN, DEBORAH ",03/15/2010,01/31/2015,Accident and Emergency department;acute coronary syndrome;Address;base;Biochemical;Biochemical Markers;Biochemistry;Biological;Biological Assay;Biological Markers;Biology;Blood;Cardiac;Cardiac Catheterization Procedures;Cardiovascular Diseases;Catheters;Chest Pain;Citric Acid Cycle;Clinical;clinical risk;Clinical Trials;cohort;Coronary Arteriosclerosis;Detection;Diagnosis;Diagnostic;Disease Management;Early treatment;Exercise stress test;experience;Goals;Heart Diseases;Human;human disease;Hypertrophic Cardiomyopathy;Image;improved;Injury;Intervention;Isotopes;Kinetics;Link;Liquid Chromatography;Mass Spectrum Analysis;Measurement;Metabolic;Metabolic Pathway;metabolomics;Monitor;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial perfusion;Nature;novel;nutrition;outcome forecast;Pathway interactions;Patient Care;Patients;Pentosephosphate Pathway;Phenotype;Physiology;Pilot Projects;Plasma;prognostic;Protocols documentation;purine metabolism;Research;Risk Factors;Sampling;Surveys;tandem mass spectrometry;Techniques;Technology;Testing;Time;Unstable angina;Validation;validation studies;Work,Metabolomic Biomarkers of Early Myocardial Injury,98280,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,,5,674769,
8622211,R01,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,R01HL102074,SCHOOLS OF MEDICINE,PA-10-067,5R01HL102074-04,NHLBI:588124\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,OKLAHOMA CITY,UNITED STATES,PHYSIOLOGY,05,878648294,US,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,OK,731171213,"  Project Narrative  Cardiovascular disease is associated with aging. For instance, the prevalence of hypertension increases with age. The purpose of the proposed research is to determine the role of klotho, a recently-discovered anti-aging gene, in the regulation of blood pressure and in the pathogenesis of spontaneous hypertension. The results will provide novel information that klotho protects the cardiovascular system. Completion of the project may offer a new therapeutic approach for hypertension and related cardiovascular disorders. The finding will benefit the US population which has a high prevalence of hypertension.",2093941;,"SUN, ZHONGJIE;","OH, YOUNGSUK ",02/15/2011,01/31/2015,Abbreviations;Age;Age-Years;aged;Aging;aging gene;Aging-Related Process;anti aging;ATP phosphohydrolase;Attenuated;Blood Pressure;Blood Pressure Monitors;blood pressure regulation;Blood Vessels;Cadherins;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Cleaved cell;Data;Dependovirus;Development;Disintegrins;Distal convoluted renal tubule structure;Endothelial Cells;Environment;Epithelial Cells;Excretory function;Functional disorder;Gene Delivery;Gene Expression;Gene Mutation;Genes;Goals;High Prevalence;Human;human SLC12A3 protein;Hypertension;hypertension control;improved;in vivo;Inbred SHR Rats;insight;Kidney;klotho protein;Knock-out;knockout gene;Longevity;Maintenance;MicroRNAs;Mortality Vital Statistics;Mus;Mutation;Myocardial Infarction;Na(+)-K(+)-Exchanging ATPase;NADPH Oxidase;novel;novel strategies;novel therapeutic intervention;overexpression;Pathogenesis;Phenotype;Play;Population;pre-B-cell colony-enhancing factor protein;Premature aging syndrome;Prevalence;Prevention strategy;Promotor (Genetics);public health relevance;receptor;recombinase;Regulation;Research;Risk Factors;Role;Smooth Muscle Myocytes;Sodium Chloride;stroke;Suppressor Genes;Telemetry;Testing;Therapeutic;Time;Tissues;Transgenes;Up-Regulation (Physiology);vascular endothelial dysfunction;Work,Regulation of Blood Pressure by Klotho,102074,HM,Hypertension and Microcirculation Study Section,,,4,588124,
8633054,R01,HL,5,N,02/05/2014,01/01/2014,12/31/2014,837,R01HL103688,,PA-09-108,5R01HL103688-04,NHLBI:601825\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MENLO PARK,UNITED STATES,,18,009232752,US,SRI INTERNATIONAL,CA,940253493,"PUBLIC HEALTH RELEVANCE: Women who are symptomatic during the menopausal transition suffer from a range of debilitating symptoms that impact their physical and mental health and that lead to major societal costs in lost productivity and health care expenditure. Sleep disturbances are a ubiquitous and particularly disruptive feature of menopause. This study will assess the relationships between autonomic nervous system dsyregulation, sleep disturbance and the response to stress in women in the early menopausal transition.         ",8654941;,"BAKER, FIONA C;","TWERY, MICHAEL ",01/15/2011,12/31/2015,Acute;Affect;Age;Arousal;Autonomic nervous system;Behavior;Blood Pressure;cardiovascular risk factor;computerized;cost;Development;Economics;effective therapy;Equilibrium;experience;Exposure to;Frequencies (time pattern);Goals;Health Expenditures;Health Transition;Healthcare Systems;heart rate variability;Hot flushes;Intervention;Laboratory Study;Lead;Link;Literature;Luteal Phase;Measures;Menopausal Symptom;Menopause;Menstrual cycle;Mental Health;middle age;Moods;Morbidity - disease rate;Nervous system structure;Neurobehavioral Manifestations;novel strategies;Parasympathetic Nervous System;Pathway interactions;Patient Self-Report;Perception;Phase;physical conditioning;Productivity;proliferative phase Menstrual cycle;Psyche structure;psychologic;Psychological Stress;public health relevance;Quality of life;Regulation;Relative (related person);Reporting;reproductive;reproductive hormone;response;Sleep;Sleep disturbances;social;Stress;stressor;Structure;Symptoms;Testing;Variant;Woman,"Sleep, Reproductive Transitions, and Health in Women",103688,MESH,"Biobehavioral Mechanisms of Emotion, Stress and Health Study Section",,,4,601825,
8606491,R01,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,R01HL105731,SCHOOLS OF MEDICINE,PA-10-067,5R01HL105731-03,NHLBI:315900\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,SURGERY,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212,"Public Health Relevance/Narrative  The leading cause of graft failure for coronary artery bypass grafting, the most common  operation performed in the United States, is intimal hyperplasia which represents a  response to injury. This proposal will identify the specific injuries that occur to the vein  graft during harvest and preparation prior to implantation as an autologous  transplanted organ and identify modalities to reduce injury to the conduit. By  understanding how these injuries can be minimized, morbidity, mortality and costs  associated with vein graft failure can be reduced.",9812145;,"CHEUNG-FLYNN, JOYCE;","REID, DIANE M.",02/01/2012,01/31/2016,Apoptosis;Attention;Autologous;Biological;Biological Preservation;Blood Vessels;Bypass;Cessation of life;claudication;Consensus;Coronary Artery Bypass;cost;Cytolysis;Data;Deposition;Development;Dyes;Etiology;Exposure to;extracellular;Extracellular Matrix;Failure (biologic function);Family suidae;FDA approved;Food;graft failure;graft function;Harvest;Human;Hyperplasia;implantation;improved;in vivo;Incidence;Infarction;Injury;intravenous administration;Investigation;Label;Lead;Limb structure;Lower Extremity;Mechanics;Membrane;Methodology;Methods;migration;Modality;Modeling;Molecular;Morbidity - disease rate;Mortality Vital Statistics;Muscle function;Myocardium;Neurologic;operation;Operative Surgical Procedures;Organ Preservation;Organ Transplantation;Outcome;Patients;Peripheral;Preparation;Procedures;Process;public health relevance;Purinoceptor;Quality of life;Rattus;receptor;Receptor Activation;Recovery;Recurrence;Research;response;response to injury;Role;Saline;Saphenous Vein;Skin;Smooth muscle (tissue);Smooth Muscle Myocytes;Spinal cord injury;Stretching;Surgeon;Techniques;Testing;Therapeutic;Tissues;Transplantation;United States;Veins,Methods To Reduce Vein Harvest Injury,105731,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",,,3,315900,
8584313,R01,HL,5,N,02/06/2014,12/01/2013,11/30/2014,837,R01HL105772,SCHOOLS OF MEDICINE,PA-10-067,5R01HL105772-03,NHLBI:351000\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,INDIANAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,603007902,US,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,IN,462022915," Here we propose a new investigation of the efficacy of and mechanisms underlying the treatment with adipose stromal or stem cells to ameliorate emphysema induced by cigarette smoke in mice. We are uniquely qualified to conduct this study, since we have a combined experience in the research of cigarette smoke-induced lung injury, and basic and translational applications of adult adipose stem cells to other diseases that involve apoptosis of capillary vascular beds. In addition, by studying how adipose stem cells rescue the bone marrow from the deleterious effects of cigarette smoking, this work will study a potentially novel mechanism of cigarette-induced injury, involving the loss of bone marrow-derived progenitor cells. Our work is therefore expected to provide the rationale for a therapeutic strategy that involves the use of ethically acceptable and easily obtainable stem cells in patients with COPD, which may be extended to other diseases in which bone marrow progenitor cell participation is key.         ",1865058;2119106 (contact);,"MARCH, KEITH LEONARD;PETRACHE, IRINA  (contact);","PUNTURIERI, ANTONELLO ",12/15/2011,11/30/2015,Accounting;Acute;Address;Adipose tissue;Adult;Alveolar;Alveolar Cell;alveolar destruction;Anti-inflammatory;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Area;Autologous;Autophagocytosis;Biological Preservation;Blood capillaries;Blood Vessels;Bone Marrow;Bone Marrow Cells;Bone Marrow Stem Cell;capillary;Cardiovascular system;Cell Death;Cell Therapy;Cells;Cerebral Ischemia;Cerebrum;Cessation of life;Chronic;Chronic Obstructive Airway Disease;Cigarette;cigarette smoke-induced;Cigarette smoke-induced emphysema;cigarette smoking;Collaborations;cytokine;Data;Development;Disease;Distal;Effectiveness;experience;Functional disorder;Future;Genes;Goals;Growth;Growth Factor;Hematopoiesis;Human;Hypocellular Bone Marrow;Inflammation;Injury;Investigation;Label;Lead;Lung;Lung diseases;lung injury;Maintenance;Mediating;Modeling;multidisciplinary;Mus;Myocardial;novel;Organ;Oxidative Stress;paracrine;Patients;Peptide Hydrolases;Perfusion;Play;Predisposition;prevent;progenitor;programs;Property;Protease Inhibitor;protective effect;Proteins;Pulmonary Emphysema;Qualifying;regenerative;release factor;repaired;Research;Role;Signal Transduction;Skeletal muscle structure;Smoke;Smoking;Source;stem cell biology;stem cell therapy;Stem cells;Stromal Cells;Suction Lipectomy;Surface;Testing;Therapeutic;tissue repair;Tissues;TNF gene;Transgenic Mice;Transplantation;vascular bed;Vascular Endothelial Growth Factors;Work,Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in Emphysema,105772,ZRG1,Special Emphasis Panel,,,3,351000,
8605214,R01,HL,5,N,02/06/2014,12/01/2013,11/30/2014,310,R01HL106160,SCHOOLS OF NUTRITION,PA-09-243,5R01HL106160-04,NHLBI:457008\OD:264307\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,NUTRITION,07,039318308,US,TUFTS UNIVERSITY BOSTON,MA,02111, Vitamin D deficiency has been linked to the development of cardiovascular disease and it is estimated that six million children are currently vitamin D deficient. This research will help to determine what supplemental doses of vitamin D may be necessary to raise serum levels to optimal levels and how vitamin D supplementation and changes in vitamin D status impact cardiovascular risk factors in schoolchildren.         ,8777129;,"SACHECK, JENNIFER;","BOYINGTON, JOSEPHINE ",06/01/2011,11/30/2014,25-hydroxyvitamin D;Academy;Address;Adult;American;Blood Glucose;blood lipid;Cardiovascular Diseases;cardiovascular risk factor;Child;Childhood;Cholecalciferol;Communities;Consensus;Data;Development;Dietary intake;Disadvantaged;Dose;eighth grade;evidence based guidelines;Exhibits;Food;Glucose;Guidelines;Health;High Density Lipoproteins;Hyperglycemia;Hypertension;Hypertriglyceridemia;improved;Insulin Resistance;Intake;Life;Link;Measures;Minority Groups;Obesity;Outcome;Overweight;Pediatrics;Physical activity;Population;prevent;Randomized;Randomized Controlled Trials;Recommendation;Research;Risk;Risk Factors;Serum;Skin Pigmentation;socioeconomics;Sun Exposure;Supplementation;Time;Vitamin D;Vitamin D Deficiency;Vitamin Deficiency;Weight;Weight maintenance regimen;Work,Impact of vitamin D supplementation on cardiometabolic risk in schoolchildren,106160,KNOD,"Kidney, Nutrition, Obesity and Diabetes Study Section",,,4,721315,
8605215,R01,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,R01HL108249,SCHOOLS OF MEDICINE,PA-10-067,5R01HL108249-03,NHLBI:326250\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HONOLULU,UNITED STATES,ANATOMY/CELL BIOLOGY,01,965088057,US,UNIVERSITY OF HAWAII AT MANOA,HI,968222234," The overall goal of this proposal is to address the role of the ABCC6 gene in chronic and acute dystrophic calcification that affects cardiac and vascular tissues. To achieve the goals of this proposal, we will use mouse models to characterize the effects of ABCC6 mutations on the structure and function of the protein, determine the response of Abcc6-/- mice to acute cardiac ischemic injuries and determine the role of Abcc6 in the calcification of the atherosclerotic plaque.         ",1890285;7757182 (contact);,"BOISVERT, WILLIAM A;LE SAUX, OLIVIER  (contact);","REID, DIANE M.",02/24/2012,01/31/2016,Acute;Address;Affect;Aging;Arterial Fatty Streak;Atherosclerosis;Backcrossings;Binding (Molecular Function);Blood Circulation;Blood Vessels;calcification;calcification inhibitor;Cardiac;Cardiovascular system;Cell membrane;Cellular translocation;Chronic;Chronic Kidney Failure;Complement;Complex;Coronary artery;Data;Deposition;Dermal;Diabetes Mellitus;Digestion;Disease;disease-causing mutation;Distal;Dystrophic Calcification;Elderly;Gene Expression;Genes;Goals;Health;Healthcare;Hepatic;Hepatocyte;Hereditary Disease;Human;human disease;Hydrolysis;hypercholesterolemia;Hyperlipidemia;improved;In Vitro;in vivo;Inflammatory;Inherited;inhibitor/antagonist;Injection of therapeutic agent;Injury;Kidney Failure;Knock-out;Knockout Mice;Ligation;Link;Liver;Location;loss of function mutation;Mechanics;Mediating;Metabolic;mineralization;Minerals;Modification;Molecular;mouse model;Mouse Protein;Mus;mutant;Mutation;novel;Pathologic Processes;Pathology;Pathway interactions;Patients;Phenotype;Population;Predisposition;protein structure function;Proteins;Pseudoxanthoma Elasticum;Publishing;Regulation;response;restoration;Role;Tail;Testing;Thalassemia;Tissues;Trypsin;Vascular calcification;Veins;Wild Type Mouse;Work,The Role of ABCC6 In Chronic &Acute Cardiovascular Mineralization,108249,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,,3,326250,
8611963,R01,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,R01HL111724,SCHOOLS OF MEDICINE,PA-10-067,5R01HL111724-03,NHLBI:623257\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,PSYCHIATRY,12,121911077,US,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,NY,10016," Hypertension (HTN) is associated with impaired cerebral vasoreactivity (VR) and flow autoregulation, which may result in greater dependence of cerebral blood flow (CBF) on perfusion pressure. Verifying this hypothesis has important implications for targeting blood pressure (BP) to ensure adequate perfusion in subjects with HTN: Should it be demonstrated, excessive BP reduction may prove detrimental for brain and cognition. Using novel MRI techniques we will systematically examine relationships between BP, CBF, VR, brain measures and cognitive performance in different groups of hypertensive subjects. We plan to provide an evidence for an optimum BP that maximizes the probability of brain and cognition preservation.         ",9991001;,"GLODZIK, LIDIA;","REID, DIANE M.",03/06/2012,01/31/2017,Aging;base;Biological Preservation;Blood Pressure;Blood Vessels;Brain;Brain Injuries;Brain region;brain tissue;brain volume;Carbon Dioxide;Cerebrovascular Circulation;Cerebrum;Cognition;Cognitive;Conflict (Psychology);Data;Dependence;Elderly;Ensure;follow-up;Functional disorder;Goals;Health;hemodynamics;Homeostasis;Hour;Human;Hypertension;hypertension treatment;Hypotension;Image;Imaging Techniques;Impaired cognition;Impairment;improved;Individual;Lead;Lesion;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mediating;Metabolic;Metric;Monitor;Morphologic artifacts;N-acetylaspartate;Neurons;normotensive;novel;Outcome;Performance;Perfusion;Physicians;Predisposition;pressure;Probability;Pulse Pressure;Reading;Regulation;Research Personnel;Resistance;Sleep;Spin Labels;Techniques;Testing;Time;white matter,"Blood Pressure, Cerebral Perfusion &Cognitive Outcome In Hypertension.",111724,ANIE,Acute Neural Injury and Epilepsy Study Section,,,3,623257,
8605550,R01,HL,5,N,02/03/2014,02/01/2014,01/31/2015,837,R01HL113352,SCHOOLS OF MEDICINE,PA-11-260,5R01HL113352-02,NHLBI:641277\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,YALE UNIVERSITY,CT,065208047,"PUBLIC HEALTH RELEVANCE: Atrial fibrillation is the most common sustained arrhythmia in humans and is a major cause of stroke, cardiovascular morbidity and mortality. This project will develop a novel approach for the evaluation of atrial structural remodeling based on the non-invasive imaging of molecular mechanisms involved in inflammation and the remodeling process. The long-term goal of this work is to non-invasively identify the substrate that predisposes to atrial fibrillation before the development of irreversible damage in order to provide early preventative intervention.            ",6711661;1880702 (contact);,"AKAR, JOSEPH GABRIEL;SINUSAS, ALBERT J (contact);","DANTHI, NARASIMHAN ",02/01/2013,01/31/2017,"AGTR2 gene;Angiotensin II;Angiotensin Receptor;Angiotensins;Apoptosis;Arrhythmia;Atrial Fibrillation;Attenuated;base;Cardiovascular system;Cell Proliferation;Chronic;Cicatrix;Collagen;Detection;Development;Disease;Early identification;Early treatment;Epidemic;Evaluation;Evolution;Extracellular Matrix;Family suidae;Fibrosis;Functional disorder;Gadolinium;gadolinium oxide;Gelatinase A;Goals;Heart Atrium;Heart failure;Human;Hybrids;Image;imaging modality;in vivo;Incidence;Inflammation;Integrins;Intervention;Lead;Ligands;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Matrix Metalloproteinases;Measures;Mediating;Medical;Methods;MMP9 gene;Modality;Modeling;Molecular;molecular imaging;Morbidity - disease rate;Mortality Vital Statistics;Myocardial;Myocardial Infarction;novel strategies;Pathogenesis;Pathway interactions;Play;prevent;Process;public health relevance;receptor;Renin;Renin-Angiotensin System;Risk;Role;Serum;Signal Transduction;Slice;socioeconomics;spatiotemporal;stroke;Tissues;Tomography, Emission-Computed, Single-Photon;Treatment Efficacy;Ventricular Remodeling;voltage;Work",Molecular Imaging Predicts Atrial Remodeling and Fibrillation Vulnerability,113352,MEDI,Medical Imaging Study Section,,,2,641277,
8606242,R01,HL,5,N,02/07/2014,02/01/2014,01/31/2015,837,R01HL116472,SCHOOLS OF MEDICINE,PA-11-260,5R01HL116472-02,NHLBI:345094\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,UNIVERSITY OF PITTSBURGH,PA,15213,PUBLIC HEALTH RELEVANCE:   One clinical hallmark of patients with severe pneumonia or sepsis-induced lung injury is a robust acute inflammatory host response triggered by invading pathogens. This study identifies novel molecular mechanisms involving the TRAF family of adaptor molecules that control cytokine expression. Execution of these studies will serve as the basis for strategies directed at the development of highly selective novel small molecule inhibitors that lessen the severity of bacterial or sepsis-induced acute lung injury.        ,10515973;,"CHEN, BEIBEI;","HARABIN, ANDREA L",02/01/2013,01/31/2018,"Acute;Adrenal Cortex Hormones;Anti-inflammatory;Anti-Inflammatory Agents;Attenuated;Bacterial Infections;base;Behavior;Clinical;cytokine;Cytokine Signaling;Data;design;Development;Disease;Effector Cell;Epithelium;F-Box Proteins;Family;Foundations;Glycogen Synthase Kinases;Hydroxychloroquine;Immune;Immune response;Immune system;improved;In Vitro;Infection;Inflammation;Inflammation Mediators;Inflammatory;inhibitor/antagonist;Invaded;Link;link protein;Lung;lung injury;Lung Injury, Acute;macrophage;Mediating;Modeling;Molecular;molecular modeling;Molecular Models;monocyte;Mortality Vital Statistics;Mus;mutant;Mutation;Natural Immunity;NF-kappa B;novel;novel strategies;Organ failure;Orphan;pathogen;Patients;Phase III Clinical Trials;Pneumonia;Process;Production;protein degradation;Protein Family;Proteins;Pseudomonas aeruginosa;public health relevance;Pulmonary Edema;receptor;Regulation;response;Role;Sepsis;Severities;Shock;Signal Transduction;small molecule;Surface;System;T-Lymphocyte;Therapeutic Intervention;TNF receptor-associated factor 1;TNF Receptor-Associated Factors;toll-like receptor 4;Transcriptional Activation;ubiquitin-protein ligase;Ubiquitination;Work",Regulation of Innate Immunity by F-Box Proteins,116472,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,,2,345094,
8610352,R01,HL,5,N,02/01/2014,02/01/2014,01/31/2015,837,R01HL116854,,PA-11-260,5R01HL116854-02,NHLBI:589034\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,07,030811269,US,"BRIGHAM AND WOMEN'S HOSP., INC.",MA,02115,"PUBLIC HEALTH RELEVANCE:  This study is designed to identify novel genetic risk factors for venous thromboembolism (VTE), a common and potentially fatal disease of blood clotting, and to study the interaction between these genetic factors and several established environmental risk factors for VTE. To do this, we will perform the first exome wide association study (XWAS) of VTE in 2500 cases and 2500 matched controls from three large prospective cohort studies, as well as a validation of prior genome wide association study (GWAS) results and a systematic analysis of the interaction between genes and four environmental risk factors we identified in our prior work. This work will provide insight into the basic pathophysiology of VTE, improve our ability to assess the risk of these blood clots in an individual and help us design strategies to prevent VTE in the general population.                ",7901741;,"KABRHEL, CHRISTOPHER;","LINK, REBECCA P.",02/01/2013,01/31/2018,American;Attention;base;Biometry;Blood Clot;Blood coagulation;Body mass index;Build-it;Candidate Disease Gene;cardiovascular disorder epidemiology;Cardiovascular system;Case-Control Studies;Cessation of life;Clinic;clinical practice;Code;cohort;Cohort Studies;Collaborations;cost effective;Custom;Data;Data Collection;Deep Vein Thrombosis;design;Disease;Employee Strikes;Enrollment;Ensure;Environmental Exposure;Environmental Risk Factor;Epidemiologic Studies;Epidemiologist;Epidemiology;Estrogens;Etiology;exome;experience;Female;flexibility;follow-up;Follow-Up Studies;Frequencies (time pattern);Functional disorder;gene environment interaction;General Population;Genes;Genetic;Genetic Polymorphism;Genetic Risk;genetic risk assessment;genetic risk factor;genetic variant;genome wide association study;genome-wide;Genotype;Health Professional;Hormones;improved;Incidence;Individual;innovation;insight;Institutes;male health;Malignant Neoplasms;Molecular Genetics;Mortality Vital Statistics;multidisciplinary;novel;Nurses;Nurses'Health Study;Obesity;Paper;Peer Review;Population;Postmenopause;Prevalence;prevent;Prevention;prospective;public health medicine (field);public health relevance;Publishing;Pulmonary Embolism;Research;Research Personnel;Risk;Risk Factors;Sampling;Single Nucleotide Polymorphism;Smoking;Staging;Surgeon;Testing;Thromboembolism;To specify;United States;Universities;Validation;Variant;Venous;Work,Genetic and Environmental Risk Factors for Venous Thromboembolism,116854,GHD,Genetics of Health and Disease Study Section,,,2,589034,
8609062,R01,MH,5,N,02/03/2014,02/01/2014,01/31/2015,242,R01MH051234,SCHOOLS OF MEDICINE,PA-07-070,5R01MH051234-18,NIMH:438005\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,004514360,US,UNIVERSITY OF PITTSBURGH,PA,15213,"PUBLIC HEALTH RELEVANCE:  Advances in the ability to identify individuals at risk for schizophrenia has created an opportunity for developing novel, disease-modifying, early interventions. The proposed studies will define the developmental trajectories of key components of prefrontal cortical circuitry that are altered in schizophrenia. These studies will delineate sensitive periods during prefrontal cortical development when pharmacological interventions in individuals vulnerable for schizophrenia might have the greatest reward, or risk, potential.                ",3137910;,"LEWIS, DAVID A;","PANCHISION, DAVID M",09/30/1995,01/31/2015,Acute;Address;Adolescence;Adult;adverse outcome;Affect;Age;Animals;Appearance;Axon;base;Behavior;Brain;cell body (neuron);Cell Count;Childhood;Clinical;Cognitive deficits;Data;density;Development;Diagnosis;Disease;Drug Targeting;early adolescence;early childhood;Early Intervention;Exhibits;Figs - dietary;Frequencies (time pattern);Future;GABA transporter;GABA-A Receptor;gamma-Aminobutyric Acid;Glutamate Decarboxylase;gray matter;high risk;hippocampal pyramidal neuron;imaging modality;Imaging Techniques;immunocytochemistry;In Vitro;in vivo;indexing;Individual;innovation;Intervention;Kinetics;Knowledge;Label;Lasers;Macaca mulatta;Maps;Measures;Mediating;Membrane;Messenger RNA;Methods;Microdissection;Molecular;Molecular Profiling;Monkeys;Myoepithelial cell;National Institute of Mental Health (U.S.);neural circuit;Neurons;Neuropil;neurotransmission;novel;Parvalbumins;Performance;Physiological;postnatal;postsynaptic;Prefrontal Cortex;presynaptic;Presynaptic Terminals;Primates;Property;Proteins;Puberty;public health relevance;Pyramidal Cells;reconstruction;Relative (related person);Reverse Transcriptase Polymerase Chain Reaction;Rewards;Risk;Schizophrenia;Short-Term Memory;Slice;Speed (motion);Staging;Strategic Planning;Symptoms;Synapses;Techniques;Testing;Time;Tissues;Transcript;young adult,Developmental Trajectories in Prefrontal GABA Circuits,51234,DBD,Developmental Brain Disorders Study Section,,,18,438005,
8605218,R01,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,R01MH053032,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01MH053032-19,NIMH:391573\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,SEATTLE,UNITED STATES,PSYCHOLOGY,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472,"PUBLIC HEALTH RELEVANCE: Steroid hormones have potential for use as neuroprotective agents in the treatment of stroke and a variety of neurodegenerative and mental health disorders. They are also of increasing concern as drugs of abuse. This work will examine the fundamental mechanisms by which these potent hormones influence neuronal birth, death, and gene expression.         ",1897940;,"BRENOWITZ, ELIOT A;","GLANZMAN, DENNIS L.",04/01/1995,01/31/2016,Address;Adult;Affective;Afferent Neurons;Apoptosis;Behavior;Behavioral;bird song;Birds;Birth;Brain;Brain region;Brain-Derived Neurotrophic Factor;Breeding;Bromodeoxyuridine;Cell Death;Cell Nucleus;Cell physiology;Cessation of life;Chimeric Proteins;cohort;Comparative Study;Data;Dental crowns;Disease;drug of abuse;Electrophysiology (science);Employee Strikes;Endocrinology;Ensure;Equilibrium;Etiology;experience;follow-up;Functional RNA;Gene Expression;Gene Family;Genes;Genetic;Genomics;Goals;Gonadal Steroid Hormones;Growth;Hormone Receptor;Hormones;Human;innovation;interdisciplinary approach;Label;Learning;Life;Link;male;Measures;Mental Depression;Mental disorders;MicroRNAs;Modeling;Molecular;Molecular Biology;Names;Nerve Degeneration;neural circuit;neurogenesis;Neuronal Plasticity;Neurons;neurophysiology;neuroprotection;Neuroprotective Agents;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 3;Neurotrophin 3;Newborn Infant;newborn neuron;novel;Outcome;Physiological;Process;programs;Prosencephalon;Proteins;public health relevance;receptor;relating to nervous system;Research;research study;Role;Schizophrenia;Scientist;Signal Transduction;Slice;Sparrows;stereotypy;steroid hormone;Steroids;stroke;Study models;System;Testing;Testosterone;Thymidine;Variant;vocal control;Work,Comparative Studies of Vocal Control,53032,SMI,Sensorimotor Integration Study Section,,,19,391573,
8610354,R01,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,R01MH057368,,PA-11-260,5R01MH057368-16,NIMH:383738\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,LA JOLLA,UNITED STATES,,49,781613492,US,SCRIPPS RESEARCH INSTITUTE,CA,920371000,PUBLIC HEALTH RELEVANCE: This grant addresses the fundamental question of how the activity of nerve cells in the brain lead to the perception of the world and memory of past experience. Many psychiatric illnesses are characterized by a disruption of these functions. The information we get from these studies would help in our understanding of these disorders and in creating new animal models in which to test treatments.            ,1901471;,"MAYFORD, MARK R;","OSBORN, BETTINA D.",02/01/2013,01/31/2018,Address;Animal Model;Animals;Area;base;Behavior Control;behavior test;Behavioral;Brain;Cells;Complex;conditioned fear;Cues;Data;Disease;Doxycycline;Electric Stimulation;experience;Freezing;Frequencies (time pattern);Fright;Generations;Genetic;Goals;Grant;Hippocampus (Brain);insight;Label;Lead;Learning;Ligands;Light;Memory;memory recall;Mental disorders;Moods;Mus;Mutation;neural patterning;neural stimulation;neuromechanism;Neurons;Neurosciences;Neurosciences Research;novel;Output;Pattern;Perception;Production;Promotor (Genetics);public health relevance;receptor;Recruitment Activity;relating to nervous system;Relative (related person);Research Design;response;Role;Sensory;sensory stimulus;Specificity;Staging;Stimulus;Structure;Testing;Time;Training;Transgenes;Update;Variant,Regulated Genetics Studies of Memory Formation,57368,ZRG1,Special Emphasis Panel,,,16,383738,
8607594,R01,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,R01MH059852,SCHOOLS OF MEDICINE,PA-10-067,5R01MH059852-14,NIMH:580408\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,PHILADELPHIA,UNITED STATES,PSYCHIATRY,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"PUBLIC HEALTH RELEVANCE: Schizophrenia is a complex genetic disorder, with early developmental abnormalities in brain structure and function being important in determining vulnerability to illness. Among the different senses, olfaction is most closely associated with the brain regions implicated in the illness. Smell abnormalities may therefore be an early warning sign of disease onset. This study will examine changes in neural responses to odors in schizophrenia patients and adolescents who are at risk for the illness. The molecular causes of these abnormalities will be studied using both olfactory epithelial biopsies and post-mortem olfactory bulb tissue. This may provide important insights into the developmental causes of schizophrenia and facilitate early intervention or prevention.            ",1910405;1891048 (contact);,"HAHN, CHANG-GYU;TURETSKY, BRUCE I (contact);","MEINECKE, DOUGLAS L.",04/01/1999,01/31/2016,Adenylate Cyclase;Adolescence;Adolescent;Adult;Age;Anatomy;Attention;Autopsy;base;behavior measurement;Behavioral;Biopsy;Brain;Brain region;clinical risk;Complex;Control Groups;Cultured Cells;Cyclic AMP;cyclic-nucleotide gated ion channels;Deltastab;Dendritic Spines;density;Development;Disease;Early Intervention;Electrodes;Epithelial;Epithelium;Evoked Potentials;Exhibits;First Degree Relative;Functional disorder;Gene Expression Profiling;Genetic Risk;Glutamates;GTP-Binding Proteins;healthy volunteer;Hereditary Disease;Histologic;Histology;Human;In Vitro;in vivo;Individual;insight;Interneurons;Investigation;Life;Location;Measures;Mediating;Modality;Modeling;Molecular;Nasal cavity;Nasal Epithelium;Natural regeneration;Neurobiology;neurodevelopment;neurogenesis;Neuronal Differentiation;Neurons;neuropathology;neurophysiology;Odors;olfactory bulb;Olfactory Cortex;Olfactory Epithelium;Olfactory Receptor Neurons;olfactory stimulus;Onset of illness;Parvalbumins;Pathology;Patients;Peripheral;Physiological;postsynaptic;Prevalence;Prevention;Process;programs;protein activation;protein expression;public health relevance;Recruitment Activity;relating to nervous system;response;Risk;scaffold;Schizophrenia;Sensory;Sensory Process;Signal Pathway;Signal Transduction;Smell Perception;Source;Structure;Symptoms;Synapses;synaptogenesis;System;Testing;Tissues;tool;Youth,Olfactory Evoked Potentials and Developmental Neuropathology in Schizophrenia,59852,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,,14,580408,
8604747,R01,MH,5,N,02/04/2014,01/28/2014,11/30/2014,242,R01MH073676,SCHOOLS OF MEDICINE,PA-07-070,5R01MH073676-09,NIMH:382670\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212,PUBLIC HEALTH RELEVANCE: Studies in patients suffering from the schizophrenia suggest that drugs that selectively activate a specific receptor for the neurotransmitter acetylcholine may provide a novel approach for treatment of this debilitating brain disorder. We have discovered new drug like molecules that selectively activate with this neurotransmitter receptor. Studies are proposed to test the hypothesis that these novel molecules have actions that predict efficacy in treatment of schizophrenia.            ,1882538;,"CONN, JEFFREY P;","BRADY, LINDA S.",04/01/2005,11/30/2015,Acetylcholine;Address;Adverse effects;Agonist;Allosteric Site;Animal Behavior;Animal Model;Animals;Antipsychotic Agents;arrestin 2;Arrestins;Behavioral;Binding Sites;Brain;Brain Diseases;Cell Line;Cell membrane;Central Nervous System Diseases;cholinergic;Cholinergic Agents;Clinical;Cognition;Cognitive;cognitive function;Coupling;Data;Development;Drug Kinetics;flexibility;Funding;human CHRM1 protein;Impaired cognition;MAPK3 gene;Mediating;Memory;Modeling;Mus;Muscarinic Acetylcholine Receptor;Muscarinic M1 Receptor;Neurons;Neurotransmitter Receptor;novel;novel strategies;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Phospholipase C;Phosphorylation;Physiological;Preparation;Process;Property;Prosencephalon;Protein Kinase;Proteins;Psychotic Disorders;public health relevance;Rattus;receptor;Receptor Activation;receptor coupling;Regulation;release of sequestered calcium ion into cytoplasm;response;Rodent Model;Role;Schizophrenia;Series;Signal Pathway;Signal Transduction;small molecule;Specificity;Structure;Symptoms;System;Testing;Therapeutic;Therapeutic Effect;transmission process,Muscarinic receptor activators as antipsychotic agents,73676,PMDA,Pathophysiological Basis of Mental Disorders and Addictions Study Section,,,9,382670,
8596737,R01,MH,5,N,02/05/2014,12/01/2013,11/30/2014,242,R01MH074006,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01MH074006-09,NIMH:342794\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,AUSTIN,UNITED STATES,BIOLOGY,21,170230239,US,"UNIVERSITY OF TEXAS, AUSTIN",TX,787121532,"PUBLIC HEALTH RELEVANCE: These studies investigate the mechanisms in prefrontal cortex of working memory. Working memory deficits are known to be associated with attention disorders such as ADD and ADHD, and with forms of age-related senility including Alzheimer's disease. As such, understanding the normal operation of working memory mechanisms is as fundamental to the treatment and prevention of these disorders as understanding how a car works is to being a car mechanic.",1960889;,"MAUK, MICHAEL D;","OSBORN, BETTINA D.",04/15/2005,11/30/2015,Acetylcholine;Affect;age related;Alzheimer's Disease;Animals;Attention;Attention deficit hyperactivity disorder;basal forebrain;base;Behavior;behavior influence;Behavioral;Cell Nucleus;Cells;Cerebellum;classical conditioning;conditioning;Data;Dementia;Disease;disorder prevention;Extinction (Psychology);eyelid conditioning;Eyelid structure;Goals;Health;Infusion procedures;insight;Knowledge;Lateral;learned behavior;Learning;Lesion;Mechanics;Mediating;Memory impairment;nervous system disorder;neuromechanism;Neurons;operation;Oryctolagus cuniculus;Output;Pathway Analysis;Play;Pontine structure;Prefrontal Cortex;Prevention strategy;Primates;Property;Prosencephalon;response;Role;Savings;Senility;Short-Term Memory;Sorting - Cell Movement;Source;Specificity;Stimulus;System;Testing;Time;Training;Work,Forebrain-Cerebellum Interactions in Trace Conditioning,74006,LAM,Neurobiology of Learning and Memory Study Section,,,9,342794,
8634138,R01,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,R01MH080716,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01MH080716-07,NIMH:362250\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,HANOVER,UNITED STATES,PSYCHOLOGY,02,041027822,US,DARTMOUTH COLLEGE,NH,03755," Facial expressions are everywhere. Indeed, we use the expressions of others on a moment-to-moment basis to predict what will happen next in our social world. The experiments proposed here will increase our understanding of the brain mechanisms involved in this learning. With this information, we can then better understand what goes wrong in the brains of individuals with major depression and anxiety disorders.         ",2055494;,"WHALEN, PAUL J;","SIMMONS, JANINE M",02/01/2007,01/31/2017,Adolescent;Adult;Affective;Amygdaloid structure;Anger;Anxiety;Anxiety Disorders;Area;Attention;attenuation;Back;base;Behavioral;Brain;Child;Clinical;Cognitive;Collaborations;Complex;Cues;Data;Development;Diffuse;directed attention;Emotional;Emotional disorder;Empathy;experience;Face;Facial Expression;Failure (biologic function);Friends;Fright;Functional Magnetic Resonance Imaging;human subject;Individual;Individual Differences;Laboratories;Learning;Longitudinal Studies;Major Depressive Disorder;Masks;Measures;Mental Depression;neuroimaging;novel;Outcome;Pathway interactions;Patients;Pattern;Personality;Persons;Population;Prefrontal Cortex;Process;psychologic;Psychologist;Publishing;Regulation;relating to nervous system;Reporting;Research;research study;response;Rest;Risk Factors;Role;showing emotion;Signal Transduction;skills;social;Social Behavior;Stimulus;Structure;Symptoms;System;Techniques;Time;Translations;white matter;Work,Prefrontal-Amygdala Interactions in Social Learning,80716,SPIP,"Social Psychology, Personality and Interpersonal Processes Study Section",,,7,362250,
8609065,R01,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,R01MH085911,SCHOOLS OF MEDICINE,PA-07-070,5R01MH085911-05,NIMH:360229\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,STANFORD,UNITED STATES,NEUROSURGERY,18,009214214,US,STANFORD UNIVERSITY,CA,943056203,"PUBLIC HEALTH RELEVANCE: Neural repair and regeneration in the brain is one of the most difficult yet potentially rewarding goals in stem cell research. In this application we take advantage of an area of the brain that naturally produces new neurons to more precisely define the microenvironment that maintains stem cells and regenerative activity throughout life. This unique neurogenic niche utilizes a complex interaction of cells and signals to maintain and regulate neurogenesis and we have recently found that extracellular matrix proteins are integral and essential in this cellular and biochemical environment. Here we propose to 1) further refine our understanding of the molecular interactions that promote or inhibit the stem cells in the generation, survival and integration of new neurons;2) evaluate the intracellular signaling cascades that underlie the phenomenon behind the generation of new neurons;3) develop and demonstrate the role of these cellular and molecular components in regulating adult neurogenesis in transgenic animal models. We anticipate that the outcome of the proposed studies will significantly advance our understanding of natural regenerative processes and provide insights into improving the efficacy of future stem cell therapies for a variety of neurological injuries and diseases.",1912114;,"PALMER, THEO D;","PANCHISION, DAVID M",04/02/2010,01/31/2015,Adopted;Adult;adult neurogenesis;Animal Model;Animals;Area;Attention;Binding (Molecular Function);Biochemical;Brain;Cell Fraction;Cell membrane;Cell Nucleus;Cell physiology;Cell Proliferation;Cell Survival;Complex;Detection;EGF gene;Environment;Epidermal Growth Factor Receptor;Exercise;experience;Extracellular Matrix Proteins;FGFR1 gene;Fibroblast Growth Factor 2;Fibroblast Growth Factor Receptors;Future;Generations;Genetic;Goals;Health;Hippocampus (Brain);improved;In Vitro;in vivo;Injury;insight;Integrins;Lead;Learning;Life;Ligands;Location;Maintenance;MAP Kinase Gene;Mediating;Mediator of activation protein;Methods;milk fat globule;Mitogen Receptors;Mitogens;Molecular;Mus;mutant;Natural regeneration;Nerve Block;nerve stem cell;nervous system disorder;Nervous System Trauma;neuroblast;neurogenesis;Neuroglia;Neurons;Newborn Infant;newborn neuron;novel;Outcome;Output;Pathway interactions;Pattern;Phosphorylation;Physical activity;Physiological;Process;Production;Proteins;receptor;regenerative;relating to nervous system;repaired;response;Rewards;RGD (sequence);Role;Running;S-Phase Fraction;self-renewal;Signal Transduction;stem;stem cell biology;Stem Cell Research;stem cell therapy;Stem cells;Stimulation of Cell Proliferation;subventricular zone;Time;Transgenic Animals,Integrin/ECM gating of adult neural stem cell activity,85911,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,,5,360229,
8633059,R01,MH,5,N,02/05/2014,01/01/2014,12/31/2014,242,R01MH093535,SCHOOLS OF MEDICINE,PA-10-067,5R01MH093535-04,NIMH:311850\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,LOS ANGELES,UNITED STATES,PSYCHIATRY,33,092530369,US,UNIVERSITY OF CALIFORNIA LOS ANGELES,CA,900952000,PUBLIC HEALTH RELEVANCE: This study will characterize brain circuitry associated with perceptual distortions and emotional processing in these severe and disabling disorders of body image to establish the neural basis for their shared and distinct clinical features. This will assist in refining classification schemes based on an understanding of underlying brain mechanisms and not merely surface symptoms and behaviors. It will also lay the foundation for future development of novel therapeutics such as perceptual retraining and emotion regulation techniques.         ,8559484;,"FEUSNER, JAMIE;","CHAVEZ, MARK ",04/01/2011,12/31/2015,Adult;Affective;Age;Amygdaloid structure;Anorexia Nervosa;Anxiety;Appearance;base;Behavior;Body Dysmorphic Disorder;Body Image;Brain;Categories;Classification Scheme;Clinical;clinical phenotype;Corpus striatum structure;Data;Deltastab;depressive symptoms;Development;Diagnostic;Disease;Dorsal;early childhood;Eating Disorders;effective therapy;emotion regulation;Emotional;emotional stimulus;Emotions;Enrollment;Exhibits;Face;Facial Expression;follow-up;food restriction;Foundations;Frequencies (time pattern);Fright;Functional Magnetic Resonance Imaging;Future;Gender;Goals;high risk;Hippocampus (Brain);Housing;Hyperactive behavior;Image;Individual;Label;Left;Limbic System;Maps;Medial;Mediating;Mental disorders;Morbidity - disease rate;Mortality Vital Statistics;neural circuit;Neurobiology;Neurocognitive;neuroimaging;Neuropsychological Tests;novel therapeutics;Pattern;Perception;Perceptual distortions;Persons;Phenotype;Prefrontal Cortex;Process;psychologic;public health relevance;Regulation;relating to nervous system;Relative (related person);Research;research study;Self Perception;Severities;Side;Stimulus;Stream;Surface;Symptoms;System;Techniques;Testing;therapy development;trait;Visual;Visual Cortex;Visual Perception;visual process;visual processing;Visuospatial;Weight;Weight Gain,Common and Distinct Phenotypes of Body Dysmorphic Disorder and Anorexia Nervosa,93535,APDA,Adult Psychopathology and Disorders of Aging Study Section,,,4,311850,
8605928,R01,MH,5,N,02/03/2014,01/01/2014,12/31/2014,242,R01MH093807,SCHOOLS OF MEDICINE,PA-10-067,5R01MH093807-04,NIMH:513365\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,SEATTLE,UNITED STATES,PHYSIOLOGY,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472," Impaired memory is an important component of diseases such as temporal lobe epilepsy, depression, schizophrenia, and Alzheimer's disease that collectively affect over twenty million Americans. Our long-range goal is to contribute to a better understanding of the neural mechanisms that underlie memory processes, in order to bring us closer to developing new therapies for these disabled patients. The objective of this proposal is to identify neural mechanisms in the hippocampus that may underlie relational memory and to determine whether the hippocampus is necessary for relational memory as distinct from memory for individual items.         ",1899606;,"BUFFALO, ELIZABETH A;","OSBORN, BETTINA D.",03/06/2012,12/31/2016,Affect;Alzheimer's Disease;American;Area;base;Behavioral;Cues;Data;Disabled Persons;Disease;Electrodes;Elements;entorhinal cortex;Event;Frequencies (time pattern);Goals;Hippocampus (Brain);Human;human subject;Individual;Knowledge;Learning;Lesion;Life;Link;Literature;Macaca mulatta;Medial;Memory;memory encoding;memory process;Mental Depression;Monkeys;mRNA Differential Displays;Nature;neuromechanism;Neurons;neurophysiology;neurotoxic;Outcome;Patients;Performance;Primates;Process;relating to nervous system;relational memory;research study;Retrieval;Role;Schizophrenia;Signal Transduction;Structure;Temporal Lobe;Temporal Lobe Epilepsy;Testing;theories;Work,The Neural Basis of Relational Memory,93807,LAM,Neurobiology of Learning and Memory Study Section,,,4,513365,
8641424,R01,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,R01MH098023,SCH OF BUSINESS/PUBLIC ADMIN,PA-11-260,5R01MH098023-02,NIMH:271559\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,BERKELEY,UNITED STATES,NONE,13,124726725,US,UNIVERSITY OF CALIFORNIA BERKELEY,CA,947045940,"PUBLIC HEALTH RELEVANCE:  The current proposal aims to study neural mechanisms of social learning in healthy adults as a precursor to understanding the impact of mental illnesses on social functioning. Changes in social behavior are often the first symptoms of a striking array of neuropsychiatric disorders. We seek to provide a unifying account of goal- directed behavior in both social and non-social settings using a neuroeconomic framework, which has the potential to lead to development of new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures.            ",8822438;,"HSU, MING;","SIMMONS, JANINE M",04/01/2013,01/31/2018,Accounting;Adult;Affect;Basal Ganglia;base;Behavior;behavior measurement;behavior test;Behavioral;behavioral impairment;Belief;Biological Markers;Brain;brain behavior;Brain region;Cognitive;computer framework;Computer Simulation;cooperative study;Data;Decision Making;Development;Dimensions;Disease;Disease Marker;Dopamine;Economics;Emotional;Employee Strikes;Evolution;frontal lobe;Functional Magnetic Resonance Imaging;Game Theory;Goals;Health;Heart;Individual;Knowledge;Lead;Learning;Legal patent;Lesion;Literature;Measures;Medial;Memory;Mental disorders;Methodology;Modeling;motivational processes;Motor;multidisciplinary;Neurobiology;neuroeconomics;neuroimaging;neuromechanism;neuropsychiatry;novel;Patients;preference;Prefrontal Cortex;Process;Psychological reinforcement;public health relevance;Race;relating to nervous system;Research Personnel;research study;Rewards;Role;Signal Transduction;social;Social Behavior;Social Functioning;Source;Suggestion;Symptoms;System;Techniques;Testing;Weight;Work,Neurobiological Substrates of Social Behavior: A Neuroeconomic Framework,98023,ZRG1,Special Emphasis Panel,,,2,271559,
8650924,R01,MH,5,N,02/03/2014,02/01/2014,01/31/2015,242,R01MH098729,SCHOOLS OF MEDICINE,PA-11-275,5R01MH098729-02,NIMH:506465\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,MILWAUKEE,UNITED STATES,PSYCHIATRY,05,937639060,US,MEDICAL COLLEGE OF WISCONSIN,WI,532263548,"PUBLIC HEALTH RELEVANCE: Russia has an expanding HIV epidemic that is increasingly characterized by sexual transmission. Contemporary antiretroviral therapies are now available, accessible, and free in major cities, but uptake is very low and most PLH are not in care. So long as a high proportion of PLH are outside of care, their health is compromised and new paradigms of treatment-as-prevention cannot achieve their potential as a strategy for reducing infectivity and future HIV incidence. This research will determine the effects of a social network-level intervention designed to reach PLH in the community-including those presently out of care-and engage them in HIV medical care systems. The approach is innovative because it enlists PLH interconnected in their social networks with other PLH in the community to establish peer norms, motivations, and supports to increase medical care uptake and adherence. Very low treatment uptake and poor HAART adherence make Russia a setting scientifically ideal for testing this approach. If successful, trial results can inform the development of similar approaches for reducing HIV incidence in the United States.            ",8104125;1859617 (contact);,"AMIRKHANIAN, YURI A;KELLY, JEFFREY A. (contact);","GORDON, CHRISTOPHER M.",04/15/2013,01/31/2018,Acquired Immunodeficiency Syndrome;Address;Adherence (attribute);Africa South of the Sahara;AIDS/HIV problem;antiretroviral therapy;Appointment;Attention;Attitude;Awareness;base;Behavior Therapy;Build-it;care systems;Caring;CD4 Lymphocyte Count;Characteristics;Cities;Communities;coping;Counseling;Country;Data;Decision Making;Development;Diagnosis;disease transmission;Eastern Europe;Enrollment;Epidemic;Friends;Future;Generations;Health;Highly Active Antiretroviral Therapy;HIV;HIV Infections;improved;Incidence;indexing;Individual;Infection;Influentials;informant;innovation;interest;International;Intervention;intervention effect;Intervention Studies;Intervention Trial;Interview;Laboratories;Life;Maintenance;Measures;Mediating;Medical;medical appointment;member;Mental Health;Methods;Modality;Modeling;Mortality Vital Statistics;Motivation;motivational enhancement therapy;Needle Sharing;novel;novel strategies;Outcome;Participant;Patients;peer;Persons;Phase;Positioning Attribute;prevent;Prevention;primary outcome;Primary Prevention;Process;Provider;psychosocial;public health medicine (field);public health relevance;Randomized;Readiness;Recruitment Activity;Regimen;Research;Rest;Risk Behaviors;Russia;Schedule;secondary outcome;Seeds;Services;Sexual Partners;Sexual Transmission;skills;Social Network;Social support;Source;standard care;Structure;Testing;theories;therapy design;Training;transmission process;treatment adherence;treatment planning;Trust;United States;Unsafe Sex;uptake;USSR;Viral Load result;Work,Social Network Intervention to Engage Out-of-Care PLH Into Treatment,98729,BSCH,Behavioral and Social Consequences of HIV/AIDS Study Section,,,2,506465,
8610357,R01,NS,5,N,02/04/2014,02/01/2014,01/31/2015,853,R01NS033202,SCHOOLS OF MEDICINE,PA-07-070,5R01NS033202-19,NINDS:371723\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,NEUROLOGY,01,005421136,US,UNIVERSITY OF CHICAGO,IL,60637,"PUBLIC HEALTH RELEVANCE: By assessing the relative contribution of different enzymatic and signaling pathways to neuromuscular weakness and synaptic degeneration in vivo, our studies of an animal model of SCS may lead to a practical strategy for therapeutic intervention with long-term benefit in SCS. These studies will also help identify pathways for postsynaptic influence on presynaptic function that may be relevant for neuromuscular disease and synaptic plasticity.            ",1869776;,"GOMEZ, CHRISTOPHER MANUEL;","PORTER, JOHN D",04/01/1995,01/31/2015,Animal Model;Apoptosis;Axotomy;base;Bungarotoxins;Calpain;calpastatin;caspase;Caspase Inhibitor;channel blockers;Cholera Toxin Protomer B;cholinergic;Cholinergic Receptors;Color;Congenital Disorders;Cyclin-Dependent Kinase 5;Data;Defect;Disease;Disease Pathway;Disease Progression;Fluoxetine;Frequencies (time pattern);Functional disorder;Goals;Impairment;improved;In Vitro;in vivo;insight;ion channel blocker;Ions;Laboratories;Lead;Limb structure;Long-Term Effects;Measures;Mediating;Messenger RNA;Metabolic;Modeling;Mus;Muscle;Muscle Fibers;mutant;Mutation;Myasthenic Syndrome;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction;neuromuscular transmission;novel;Pathogenesis;Pathway interactions;Peptide Hydrolases;Phase;postsynaptic;presynaptic;Production;Proteins;public health relevance;Quinidine;receptor;receptor density;Receptor Gene;Recombinants;Recycling;Relative (related person);retrograde transport;Role;Sarcoplasm;screening;Serotonin Agents;Signal Pathway;Source;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Syndrome;Testing;Therapeutic;Therapeutic Intervention;Toxin;Transfection;Transgenic Mice;Transgenic Organisms;uptake;Vesicle,Acetylcholine Receptor Genes in Slow-Channel Syndrome,33202,ZRG1,Special Emphasis Panel,,,19,371723,
8606514,R01,NS,5,N,02/04/2014,02/01/2014,01/31/2015,853,R01NS041021,SCHOOLS OF MEDICINE,PA-12-270,5R01NS041021-13,NINDS:299250\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAINT LOUIS,UNITED STATES,NEUROSCIENCES,01,068552207,US,WASHINGTON UNIVERSITY,MO,631304862,"PUBLIC HEALTH RELEVANCE: Neuronal positioning represents a fundamental prerequisite step in the establishment of neural circuits in the brain. We propose to identify the key mechanisms and principles that govern neuronal positioning in brain development. Abnormalities of neuronal positioning contribute to the pathogenesis of mental retardation and epilepsy syndromes. Therefore, understanding the mechanisms that control neuronal positioning is not only essential for a better understanding of brain development but also for insights into a whole host of brain disorders.                ",2110180;,"BONNI, AZAD;","RIDDLE, ROBERT D.",02/03/2013,01/31/2018,Address;base;Binding Sites;Bioinformatics;Biological;Biological Assay;Brain;Brain Diseases;Cells;Cerebellar cortex structure;Cerebral cortex;Cognition;Complex;Cytoplasmic Granules;Data;Dendrites;Development;Disease;Epilepsy;Gene Targeting;Genes;Genetic Transcription;Goals;in vivo;In-Migration;Inherited;insight;Integral Membrane Protein;Knock-out;Lead;Light;Link;lissencephaly;Mediating;Mental Retardation;migration;Morphogenesis;Mus;neural circuit;Neurodevelopmental Disorder;neuron development;Neurons;novel;Pathogenesis;Pathway interactions;Phenocopy;Play;Positioning Attribute;postnatal;Promotor (Genetics);Protein Isoforms;Proteins;Proteomics;public health relevance;pup;Rattus;Regulation;Research;research study;RNA Interference;RNA Splicing;Role;Signal Transduction Pathway;Site;Slice;Syndrome;System;Tertiary Protein Structure;Testing;Time;transcription factor;Transcription Repressor/Corepressor;Transcriptional Regulation;ubiquitin-protein ligase,SIGNAL TRANSDUCTION PATHWAYS REGULATING NEURON DIFFERENTIATION,41021,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,,13,299250,
8616406,R01,NS,5,N,02/03/2014,02/01/2014,01/31/2015,853,R01NS041669,SCHOOLS OF MEDICINE,PA-10-067,5R01NS041669-13,NINDS:301908\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,GENETICS,05,066469933,US,EMORY UNIVERSITY,GA,30322,"PUBLIC HEALTH RELEVANCE:  Huntington disease (HD) is the most common form of polyglutamine diseases that are featured by abnormal gene expression caused by mutant proteins in the nucleus. In this application, we will use genetic mouse models of HD to investigate the mechanism by which the HD protein accumulates in neuronal nucleus. Elucidating this mechanism will help find therapeutic intervention to reduce HD neuropathology.         ",1878496;,"LI, XIAO-JIANG;","SUTHERLAND, MARGARET L",05/01/2001,01/31/2016,Accounting;Affect;Amino Acids;Antibodies;Brain;Brain region;Cell Nucleus;cell type;Cells;Corpus striatum structure;Disease;effective therapy;Family;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Transcription;human Huntingtin protein;Huntington Disease;Inherited;Investigation;Knock-in Mouse;Length;Mediating;mouse model;Mus;mutant;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurologic;Neurons;neuropathology;Nuclear;Nuclear Proteins;overexpression;Pathogenesis;Patients;Phenotype;Phosphorylation;polyglutamine;Protein Binding;Proteins;public health relevance;Research;Site;stem;Symptoms;System;Testing;Therapeutic;Therapeutic Intervention;therapy development;Toxic effect;transcription factor;Transgenic Mice,Nuclear Toxicity of Huntington Disease Protein,41669,CDIN,Cell Death and Injury in Neurodegeneration Study Section,,,13,301908,
8616407,R01,NS,5,N,02/07/2014,02/01/2014,01/31/2015,853,R01NS054022,SCHOOLS OF MEDICINE,PA-10-067,5R01NS054022-09,NINDS:309094\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DURHAM,UNITED STATES,PHARMACOLOGY,04,044387793,US,DUKE UNIVERSITY,NC,27705,"PUBLIC HEALTH RELEVANCE: The accumulation of toxic protein aggregates and impaired mitochondrial function has emerged as a common denominator in neurodegenerative diseases. By characterizing the mechanism and protein machinery that eliminate toxic protein aggregates and damaged mitochondria, we hope to identify new avenues for developing novel therapeutic approaches for treating neurodegenerative disease.            ",6190066;,"YAO, TSO-PANG;","SUTHERLAND, MARGARET L",01/04/2006,01/31/2015,Actins;Autophagocytosis;Autophagosome;base;Binding (Molecular Function);Biochemical;Cell physiology;Cells;Code;Complex;Deacetylase;Dependence;Disease;Disease model;Endocytic Vesicle;F-Actin;G Actin;HDAC6 gene;histone deacetylase 6;human FRAP1 protein;insight;Lesion;Lewy Bodies;Link;Lysosomes;Mediating;Mitochondria;Molecular;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;novel;novel therapeutic intervention;particle;Pathogenesis;Pathway interactions;Phosphotransferases;Play;Population;Process;Property;protein aggregate;Proteins;public health relevance;Quality Control;Raptors;Reading;Regulation;Regulatory Element;Role;Route;secretion process;Signal Pathway;Signaling Molecule;Sirolimus;Starvation;Testing;To specify;Toxic effect;transmission process;TSG101 gene;Ubiquitin;Ubiquitination;Viral;Work,Histone deacetylase 6 and aggresome-associated neurodegeneration,54022,CMND,Cellular and Molecular Biology of Neurodegeneration Study Section,,,9,309094,
8606258,R01,NS,5,N,02/05/2014,02/01/2014,01/31/2015,853,R01NS055829,SCHOOLS OF MEDICINE,PA-10-067,5R01NS055829-07,NINDS:327797\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,NEUROLOGY,03,043207562,US,YALE UNIVERSITY,CT,065208047," RELEVANCE: Impaired attention during and between absence seizures has a major negative impact on patient quality of life due to deficits in school performance, potential for injuries, and social stigma. By understanding the fundamental mechanisms and brain regions crucial for impaired attention in this patient population, new targeted therapies may be developed with the goal of blocking seizures and preserving attention. Understanding mechanisms of impaired attention in this form of epilepsy may have implications for treating other types of epilepsy as well.",1927448;,"BLUMENFELD, HAL;","FUREMAN, BRANDY E",08/02/2006,01/31/2017,Absence Epilepsy;Affect;Anterior;Area;Attention;base;Behavior;behavior test;Behavioral;Brain;Brain region;Characteristics;Child;Chronic;Complex;Data;data modeling;Disease;Electroencephalography;Electrophysiology (science);Epilepsy;Frequencies (time pattern);frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Generalized Epilepsy;Goals;Graph;hemodynamics;Impairment;improved;Injury;Insula of Reil;Investigation;Lead;Location;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medial;Methods;Nervous System Physiology;network dysfunction;neuroimaging;patient population;Patients;Pattern;Performance;prevent;Quality of life;relating to nervous system;research study;response;Rest;sample fixation;Schools;Seizures;Severities;Signal Transduction;social stigma;spatiotemporal;Task Performances;Thalamic structure;Time;vigilance;Work,Functional Neuroimaging in Childhood Absence Epilepsy,55829,ANIE,Acute Neural Injury and Epilepsy Study Section,,,7,327797,
8605935,R01,NS,5,N,02/05/2014,02/01/2014,01/31/2015,853,R01NS062219,,PAS-08-048,5R01NS062219-05,NINDS:320643\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,07,030811269,US,"BRIGHAM AND WOMEN'S HOSP., INC.",MA,02115,"PUBLIC HEALTH RELEVANCE: The intracellular mechanisms regulating glioma invasion of the surrounding brain remain poorly understood. We have identified a novel intracellular pathway that regulates glioma migration and involves the cyclin-dependent kinase-associated phosphatase, KAP, Rho kinase and Cdc2 kinase. Dysregulation of this pathway defines a subpopulation of glioblastomas associated with poor patient outcome. This project will examine the downstream effector mechanisms of this KAP/ROCK/Cdc2 invasion pathway in human CD133+ glioblastoma-derived stem-like cells and in established glioma cell lines. The effect of Cdc2 kinase inhibition on glioblastoma dispersal and overall survival will also be determined using a mouse intracranial human glioma transplantation model.         ",1907208;,"JOHNSON, MARK D;","FOUNTAIN, JANE W.",02/01/2010,01/31/2015,Actins;Area;Biological Assay;Brain;caldesmon;Cancer stem cell;cell motility;Cells;Clinical Trials;Cyclin D1;Cyclin-Dependent Kinase Inhibitor 3;Cyclin-Dependent Kinases;Cytoskeletal Modeling;Dominant-Negative Mutation;Excision;Focal Adhesions;Genetic Transcription;Glioblastoma;Glioma;glioma cell line;Human;In Vitro;in vivo;inhibitor/antagonist;kinase inhibitor;Lesion;Life;Malignant Glioma;Mediating;Messenger RNA;Microtubules;migration;Modeling;Mus;Myosin Light Chain Kinase;Myosin Light Chains;novel;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;Patients;Peripheral;Phosphorylation;Phosphotransferases;Play;prevent;Proteins;PTK2 gene;public health relevance;Recurrence;research study;Rho-associated kinase;RNA Interference;RNA Splicing;Role;Small Interfering RNA;small molecule;stem;Therapeutic;therapy development;Transplantation;tumor;Tumor Suppressor Proteins,Preventing Glioma Cancer Stem Cell Dispersal Using Cdc2 Kinase Inhibitors,62219,DT,Developmental Therapeutics Study Section,,,5,320643,
8608011,R01,NS,5,N,02/04/2014,02/01/2014,01/31/2015,853,R01NS064583,SCHOOLS OF MEDICINE,PA-08-015,5R01NS064583-05,NINDS:327030\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,BIOLOGY,07,047006379,US,HARVARD UNIVERSITY (MEDICAL SCHOOL),MA,02115,"PUBLIC HEALTH RELEVANCE:  Understanding the interactions between vascular and nervous systems will advance the diagnosis, therapy, and prevention of several neurological diseases, including diabetic neuropathy and trigeminal neuralgia.  Moreover, emerging evidence shows some neurodegenerative diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), that once were thought to be caused primarily by intrinsic neuronal defects, actually may be related to vascular abnormalities. Finally, since mechanisms that control angiogenesis during development are likely to be essential for neovascularization in tumors, this study may have a direct impact on cancer treatment.        ",6269870;,"GU, CHENGHUA;","RIDDLE, ROBERT D.",02/01/2010,01/31/2015,Address;Adult;Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;angiogenesis;Axon;axon guidance;base;Blood capillaries;Blood Vessels;Brain;cancer therapy;capillary;cell motility;cell type;Cells;Complex;Coupled;Cues;Data;Defect;Dependency (Psychology);Development;Diabetic Neuropathies;Diagnosis;DNA Sequence Rearrangement;Endothelial Cells;Genetic;Genetically Engineered Mouse;genome wide association study;Growth Cones;GTPase-Activating Proteins;Heart Rate;Human;Image;improved;in vitro Assay;in vivo;insight;Knockout Mice;Ligands;Mediating;Modeling;Molecular;mouse model;Multiple Sclerosis;Mus;neovascularization;Nerve;nerve supply;nervous system disorder;Nervous system structure;neural circuit;Neuraxis;Neurodegenerative Disorders;neuron development;Neurons;novel;Nutrient;Oxygen;pathogen;Pathway interactions;Pattern;Peripheral;Peripheral Nervous System Diseases;Play;plexin;prevent;Prevention therapy;protein function;Protein-Serine-Threonine Kinases;public health relevance;receptor;Recruitment Activity;relating to nervous system;research study;response;RNA Interference;Role;Running;Semaphorins;Sensory;Signal Transduction;Signaling Molecule;Signaling Protein;somatosensory;Structure;System;Testing;Toxin;Trigeminal Neuralgia;Trigeminal System;tumor;Vascular System;Vibrissae,The Role of Semaphorins in Axon and Blood Vessel Guidance,64583,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,,5,327030,
8616408,R01,NS,5,N,02/07/2014,02/01/2014,01/31/2015,853,R01NS065874,SCHOOLS OF MEDICINE,PA-07-070,5R01NS065874-05,NINDS:298089\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LA JOLLA,UNITED STATES,PEDIATRICS,52,804355790,US,UNIVERSITY OF CALIFORNIA SAN DIEGO,CA,920930934,"PUBLIC HEALTH RELEVANCE: Studies of Huntington's disease (HD) and other related neurodegenerative disorders have highlighted the importance of mitochondrial function and bioenergetics in the maintenance of normal neural function. In this project, we will examine the exciting hypothesis that PPAR4 is involved in the maintenance of neuronal energy generation and that altered function of PPAR4 contributes to HD neurodegeneration. If PPAR4 is involved in this neurological disease, then tractable therapies to boost PPAR4 function would be tested, as highly selective and powerful pharmacological agonists for PPAR4 have been developed and are in use in humans, and PPAR4 mediates pro-survival signaling in response to retinoic acid.            ",1926731;,"LA SPADA, ALBERT R;","SUTHERLAND, MARGARET L",02/01/2010,01/31/2015,Affect;Agonist;base;Bioenergetics;Biological Assay;Brain;Brain region;Cataloging;Catalogs;Cell Death;Cell physiology;Cells;cellular retinoic acid binding protein;Co-Immunoprecipitations;Corpus striatum structure;Development;Disease;disease phenotype;Dominant-Negative Mutation;Energy Metabolism;FABP5 gene;Gene Expression;Gene Expression Profile;Gene Targeting;Generations;Genetic;Genetic Transcription;Health;Human;human Huntingtin protein;Huntington Disease;In Vitro;in vivo;Investigation;Knock-in Mouse;Laboratories;Lead;Ligands;Link;Maintenance;Mediating;Microarray Analysis;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;mutant;Nature;Nerve Degeneration;nervous system disorder;nestin protein;Neurodegenerative Disorders;neurodegenerative phenotype;Neurologic;Neurons;Neurophysiology - biologic function;neurotoxicity;Nuclear;Nuclear Receptors;Pathogenesis;Pathway interactions;Peroxisome Proliferator-Activated Receptors;Phenotype;Play;polyglutamine;PPAR delta;PPAR Pathway;protein expression;Proteins;public health relevance;Publishing;Regulation;relating to nervous system;research study;response;Retinol Binding Proteins;Role;Signal Transduction;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;Trans-Activation (Genetics);transcription factor;Transgenic Mice;Treatment Efficacy;Tretinoin;Work,The PPAR-delta pathway in neural function and Hungtington's disease neuropatholog,65874,ZRG1,Special Emphasis Panel,,,5,298089,
8608014,R01,NS,5,N,02/04/2014,02/01/2014,01/31/2015,853,R01NS075007,SCHOOLS OF ARTS AND SCIENCES,PA-10-067,5R01NS075007-03,NINDS:318527\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WALTHAM,UNITED STATES,BIOLOGY,05,616845814,US,BRANDEIS UNIVERSITY,MA,024549110," Project Narrative Neuronal cell types are the functional building blocks of the brain. We will create a Database of Mammalian Neuronal Cell-types. To enhance the usefulness of this effort we will generate new strains of mice that allow genetic targeting of specific cell types and will profile the gene expression patterns that make cell types different from one another. The great majority of brain diseases are diseases that primarily affect specific cell types, and therefore integrating and improving our understanding of cell types in the mammalian brain may help study of these diseases.",1863447;,"NELSON, SACHA B;","RIDDLE, ROBERT D.",02/01/2012,01/31/2017,abstracting;Affect;Atlases;Automobile Driving;base;Biology;Brain;Brain Diseases;Brain Mapping;Brain region;cell type;Cells;Classification;Collaborations;Communities;Complement;Data;Databases;Development;diencephalon;Disease;Enhancers;Family;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Transfer Techniques;Genes;Genetic;Genome;genome-wide;Genomics;Glutamates;imaging informatics;improved;Individual;insight;Knowledge;Label;Link;Location;member;Metric;Molecular;Molecular Profiling;Morphology;Mouse Strains;Mus;nervous system disorder;Neurons;novel;novel strategies;Ontology;open source;Phenotype;Physiology;Promotor (Genetics);Property;Prosencephalon;Protein Family;Reagent;recombinase;Recruitment Activity;Relative (related person);Reporter;Resources;Sampling;Scheme;sharing data;Specific qualifier value;Telencephalon;Tetanus Helper Peptide;tool;Trans-Activators;Transgenic Mice;Transgenic Organisms,A Database of Mammalian Neuronal Cell Types,75007,ZRG1,Special Emphasis Panel,,,3,318527,
8617878,R01,NS,5,N,02/04/2014,02/01/2014,01/31/2015,853,R01NS079374,SCHOOLS OF MEDICINE,PA-11-260,5R01NS079374-02,NINDS:371310\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MINNEAPOLIS,UNITED STATES,NEUROLOGY,05,555917996,US,UNIVERSITY OF MINNESOTA,MN,554552070,"Project Narrative  The central focus of this proposal explores how to fill a knowledge gap - the identification of  specific tau species disrupting neural and brain function. The identification of such molecular  entities will enable us to lay the biological foundation for discovering drugs that may block tau-  related neurotoxicity in Alzheimer's disease and other tauopathies. This project intends to  improve both our understanding of the processes that initiate AD and our ability to treat it in its  earliest stages, by determining whether specific forms of tau interfere memory function and  with neurotransmitter receptor trafficking in dendritic spines, the principal loci of synaptic  plasticity underlying learning and memory. Since this abnormal process occurs prior to the loss  of neurons, these pathogenic tau species could become a target for therapies aimed at  preventing tauopathies from developing into progressive, fatal dementias. If successful, the  work could benefit millions of people in America and the world.",1862196;,"ASHE, KAREN H;","CORRIVEAU, RODERICK A",02/15/2013,01/31/2017,Alzheimer's Disease;Americas;Aspartate;Binding Proteins;Biological;Biological Assay;Brain;brain tissue;caspase-2;Cleaved cell;Cognition;Cognitive;cognitive function;Data;Dementia;Dendritic Spines;Development;Drug Targeting;Foundations;Frontotemporal Dementia;Functional disorder;Glutamate Receptor;Goals;Impaired cognition;improved;Knowledge;Learning;Link;Measures;Mediating;Memory;Memory impairment;Microtubules;mild cognitive impairment;Modification;Molecular;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuron loss;Neurons;neurotoxicity;Neurotransmitter Receptor;novel;Patients;Pharmaceutical Preparations;Play;prevent;Process;Rattus;relating to nervous system;Resistance;Role;Science;Staging;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;tau mutation;tau Proteins;Tauopathies;Testing;trafficking;Transgenic Mice;Transgenic Organisms;Variant;Vertebral column;Work,Role of Tau Cleavage in Tauopathy,79374,CMND,Cellular and Molecular Biology of Neurodegeneration Study Section,,,2,371310,
8601419,R18,HS,5,N,02/04/2014,02/01/2014,12/31/2014,,R18HS021945,,RFA-HS-12-006,5R18HS021945-02,,Other Research Related,2014,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,COLUMBIA,UNITED STATES,,07,175185230,US,AMERICAN MEDICAL DIRECTORS ASSOCIATION,MD,21044,"PUBLIC HEALTH RELEVANCE: The development of an interactive, web-based educational program based on the American Medical Directors Association's evidence-based guidelines for management of nursing home residents with dementia will decrease the inappropriate use of atypical antipsychotic medications for nursing home residents with dementia, improving compliance with the Food and Drug Administration's black box warning issued in September 2006. This initiative is especially relevant at this time since the Centers for Medicare and Medicaid have recently launched the Initiative to Improve Behavioral Health and Reduce the Use of Antipsychotic Medications in Nursing Home Residents, with a goal of reducing the use of antipsychotic drugs in nursing home residents by 15% by the end of 2012;and will be posting individual nursing home data on antipsychotic drug use on the CMS Nursing Home Compare web site.            ",11373223;,"VOLICER, LADISLAV;","BARTMAN, BARBARA ",01/01/2013,12/31/2014,,Development and evaluation of online CME course for disseminating clinical guidel,21945,ZHS1,Special Emphasis Panel,,,2,,
8449204,R21,AR,5,N,04/12/2013,04/01/2013,03/31/2014,846,R21AR062826,,PA-10-069,5R21AR062826-02,NIAMS:173138\,Research Projects,2013,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BALTIMORE,UNITED STATES,,03,001910777,US,JOHNS HOPKINS UNIVERSITY,MD,21218, We seek to understand how non-neuronal skin cells help the nervous system detect and respond to painful environmental stimuli. A better understanding of this communication within the skin will aid the development of improved drugs to fight chronic pain that lack the unwanted side effects that limit the usefulness of currently available pain medications.                ,1892087;,"CATERINA, MICHAEL J;","TSENG, HUNG H",04/01/2012,03/31/2014,Acute;Address;Adverse effects;Affect;Afferent Neurons;Agonist;Analgesics;Apical;arm;base;Behavior;Behavioral;Biological Assay;Capsaicin;Cells;Chemicals;chronic pain;Communication;Cutaneous;Development;Dose-Limiting;Epidermis;Epithelial Cells;Event;Exhibits;fighting;FOS gene;Future;Generations;Grant;Histologic;improved;in vivo;information processing;insight;Intervention;Ion Channel;keratinocyte;Lead;Light;Mechanics;Mediator of activation protein;Monitor;Mus;Nervous system structure;Neurons;Nociception;Nociceptors;Outcome;Pain;Pain management;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Promotor (Genetics);public health medicine (field);receptor;Receptor Activation;receptor expression;Regulation;research study;Resolution;response;Role;selective expression;Signal Transduction;Skin;spatiotemporal;Specificity;Spinal Cord;Spinal cord posterior horn;Stimulus;success;Testing;Therapeutic;Therapeutic Agents;tool;transcription factor;Transgenic Mice;Transgenic Organisms;TRPV1 gene,Transgenic Regulation of Keratinocyte to Nociceptor Signaling,62826,SCS,Somatosensory and Chemosensory Systems Study Section,,,2,173138,
8606442,R21,CA,5,N,02/07/2014,01/01/2014,12/31/2014,393,R21CA165939,SCHOOLS OF MEDICINE,PAR-10-137,5R21CA165939-03,NCI:155622\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,PISCATAWAY,UNITED STATES,FAMILY MEDICINE,06,078795875,US,RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL,NJ,088548021,"PUBLIC HEALTH RELEVANCE: This feasibility study will pilot-test an educational intervention to decrease weight bias among health professionals in community health care settings. Minority women are disproportionately subjected to weight bias, which increases poor eating habits, refusal to diet, avoidance of exercise, and delays in cancer screenings. Improving health professionals'behaviors toward obese persons may have great potential impact in improving health care delivery for a high number of underserved minority women with obesity who are at risk for cancer disparities. .            ",7066103;,"FERRANTE, JEANNE M;","SMITH, ASHLEY ",01/18/2013,12/31/2014,Address;Adult;African American;Attitude;base;Baseline Surveys;Behavior;behavioral health;Belief;Body Weight decreased;cancer health disparity;Communities;Community Health Centers;Community Healthcare;Counseling;Data;Data Collection;Diet;Diet Habits;Discrimination (Psychology);Economics;Educational aspects;Educational Intervention;Effectiveness of Interventions;Emotional;Empathy;Environment;Equipment;Exercise;experience;Family Physicians;Feasibility Studies;follow-up;Food Policy;Future;Health;Health behavior;health care delivery;health disparity;Health Professional;Healthcare;High Prevalence;improved;Incidence;Individual;innovation;Intervention;Interview;Malignant Neoplasms;Mediator of activation protein;Medical;Medical Students;member;Methods;middle age;Minority;Mortality Vital Statistics;Motivation;motivational enhancement therapy;Obesity;obesity management;Outcome;Overweight;patient oriented;Patients;Persons;physical conditioning;Pilot Projects;population based;Prejudice;Prevalence;Preventive;Preventive screening;primary care setting;Primary Health Care;Procedures;public health relevance;Qualifying;Race;Randomized Clinical Trials;Randomized Controlled Trials;Reporting;Research;Research Personnel;Resources;Risk;Sampling;satisfaction;Screening for cancer;Self-Administered;social;social stigma;Source;Staff Attitudes;Stereotyping;Surveys;Testing;theories;Treatment outcome;Underrepresented Minority;Weight;Weight Perception;Woman;Work,Reducing Health Disparities by Decreasing Weight Bias in Community Healthcare Set,165939,HDEP,Health Disparities and Equity Promotion Study Section,,,3,155622,
8651509,R21,HG,5,N,02/01/2014,02/01/2014,01/31/2015,172,R21HG007200,,PA-11-261,5R21HG007200-02,NHGRI:132840\,Research Projects,2014,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,VILNIUS,LITHUANIA,,,565687043,LH,VILNIAUS UNIVERSITETAS,,,"PUBLIC HEALTH RELEVANCE:     Changes in cytosine modification patterns in the genome may predispose individuals to various human diseases, including cancer, schizophrenia, autism, asthma, and diabetes. Research into the epigenetic misregulation in human disease is hampered by the lack of high resolution and cost-effective techniques. Our new technologies for single-nucleotide analysis of cytosine modifications will be an indispensible addition to the tool box of comprehensive epigenomic studies.            ",11378909;,"KLIMASAUSKAS, SAULIUS;","PAZIN, MICHAEL J",04/12/2013,01/31/2015,Area;Asthma;Autistic Disorder;base;bisulfite;Boxing;Brain;Cells;Complex;cost effective;CpG dinucleotide;Cytosine;demethylation;Diabetes Mellitus;DNA;DNA biosynthesis;DNA Methylation;DNA Structure;DNA-Directed DNA Polymerase;Economics;embryonic stem cell;Epigenetic Process;epigenome;epigenomics;Generations;Genome;genome sequencing;genome-wide;genome-wide analysis;Genomics;human disease;human DNA;human tissue;Individual;Invaded;Malignant Neoplasms;mammalian genome;Mammals;Maps;Methods;Methyltransferase;Modification;Morphologic artifacts;Mus;Names;Neurons;new technology;Nucleotide Mapping;Nucleotides;Oxygenases;Pattern;Polymerase;Positioning Attribute;Process;Protocols documentation;public health relevance;Pyrimidine;Reaction;Regulation;Research;Resolution;Role;Sampling;Schizophrenia;Signal Transduction;single molecule;Site;Techniques;tool,Direct single nucleotide mapping of genomic CpG marks,7200,GCAT,"Genomics, Computational Biology and Technology Study Section",,,2,132840,
8653976,R21,HG,5,N,02/01/2014,02/01/2014,01/31/2015,172,R21HG007201,SCHOOLS OF MEDICINE,PA-11-261,5R21HG007201-02,NHGRI:193125\,Research Projects,2014,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,SEATTLE,UNITED STATES,GENETICS,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472,"PUBLIC HEALTH RELEVANCE:     Understanding gene-gene interactions will be key to interpreting human variation and its role in human disease. We propose to develop methods to investigate gene-gene interactions on a genome-wide scale in the nematode C. elegans, which would allow the first large-scale application of synthetic gene interactions in higher eukaryotes. Beyond providing a more complete understanding of gene function in C. elegans, our studies may provide a model for similar studies in more complicated organisms and will provide a framework for understanding gene-gene interaction in humans.              ",1882963;,"WATERSTON, ROBERT H;","PAZIN, MICHAEL J",04/18/2013,01/31/2015,Backcrossings;Biological Assay;Biology;Caenorhabditis elegans;Collection;Communities;Complex;cost effective;Custom;design;Development;dimer;Enhancers;Eukaryota;expectation;Family;Gene Deletion;gene function;gene interaction;Generations;Genes;Genetic;genetic analysis;Genetic Models;Genome;genome-wide;Growth;Human;human disease;Individual;insight;Investigation;Lead;Link;Literature;Measures;member;Methods;Modeling;Molecular;mutant;Mutation;Nature;Nematoda;next generation sequencing;Organism;Phenotype;Population;Population Genetics;Potassium Channel;Process;public health relevance;Relative (related person);Resources;RNA Interference;Role;Site;Staging;success;Synthetic Genes;System;Technology;Testing;Variant;Yeasts,High throughput methods for Synthetic Genetic Array Analysis in C. elegans,7201,GCAT,"Genomics, Computational Biology and Technology Study Section",,,2,193125,
8606240,R21,HL,5,N,02/07/2014,02/01/2014,01/31/2015,837,R21HL113809,SCHOOLS OF MEDICINE,PA-11-261,5R21HL113809-02,NHLBI:174141\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"PUBLIC HEALTH RELEVANCE: The Metabolic Syndrome (MS) is an independent risk factor for inflammatory diseases of the lung, and improved understanding of the mechanism by which MS contributes to lung inflammation offers hope for the development of new treatment strategies. Chronic, low grade systemic inflammation is a component of MS that may promote lung inflammation in part through the proinflammatory properties of uric acid (UA), which is increased in MS patients. This grant application will advance our knowledge of MS mediated inflammatory lung disease by characterizing the role of XOR and UA in novel robust mouse models of MS that will be validated by prospective analysis of MS associated inflammatory lung disease in humans. Data produced by this study may recommend UA as an important parameter for measurement in human clinical trials and may indicate its relevance as a therapeutic target in the management of MS associated lung inflammatory disorders        ",7354134;1887389 (contact);,"JOHNSON, RICHARD JOSEPH;WRIGHT, RICHARD M (contact);","HARABIN, ANDREA L",02/01/2013,01/31/2015,"Ablation;Acute;Adhesions;Adipocytes;adiponectin;Adult Respiratory Distress Syndrome;Affect;Animal Model;Applications Grants;Cardiovascular Diseases;CCL2 gene;Chronic;Chronic Obstructive Airway Disease;Clinical;Clinical Trials;Colorado;Comorbidity;Complex;cytokine;Data;Development;Disease;Enrollment;Enzymes;Exhibits;feeding;Fructose;Generations;Genetic;Genetic Models;Grant;Heel;Hepatocyte;Hospitals;Human;Hyperglycemia;Hypertension;Hyperuricemia;improved;in vivo;Inflammation;Inflammatory;inhibitor/antagonist;Insufflation;Insulin Resistance;knock-down;Knock-out;Knockout Mice;Knowledge;Leukocytes;Lung;Lung diseases;Lung Inflammation;Lung Injury, Acute;Measurement;Mediating;Mediator of activation protein;Metabolic syndrome;Modeling;Mononuclear;mouse model;Mouse Strains;Mus;Natural Immunity;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Patients;Phagocytes;Positioning Attribute;Process;Property;prospective;public health relevance;Publishing;recombinase;Reperfusion Injury;research study;Risk Factors;Rodent Model;Role;Serum;Signaling Molecule;small hairpin RNA;Source;System;therapeutic target;treatment strategy;Universities;Uric Acid;Work;Xanthine Dehydrogenase",PROINFLAMMATORY ROLE OF URIC ACID IN LUNG DISEASE: NOVEL MODELS AND CLINICAL VALI,113809,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,,2,174141,
8606517,R21,NS,5,N,02/06/2014,02/01/2014,01/31/2015,853,R21NS070202,SCH ALLIED HEALTH PROFESSIONS,PA-11-261,5R21NS070202-02,NINDS:174226\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,KENMORE,UNITED STATES,OTHER BASIC SCIENCES,01,055652309,US,BASTYR UNIVERSITY,WA,980284966,"PUBLIC HEALTH RELEVANCE: This study will investigate changes in iron homeostasis in serum and brain of idiopathic Parkinson's disease (PD) patients. The total number of participants who will undergo serum tests will be 442, and 50 of the participants will also undergo MRI scans. By testing blood iron and brain iron by MRI, we will test the hypothesis that low serum iron corresponds to higher levels of brain iron. If this hypothesis is true, it will provde important new insights into mechanisms of PD, since excessive iron deposition in the brain has been shown to be involved in neurodegeneration. Smoking has been known to protect from PD risk, but the mechanism for this epidemiological finding is still unknown: in this study we will alo test the novel hypothesis that smoking protects from PD by changing iron homeostasis: we will investigate if cigarette smoking causes an increase of serum iron levels and a decrease of brain iron. Finally, we will investigate the effect of a common polymorphism for haptoglobin (Hp), a protein that binds hemoglobin and regulates iron homeostasis. The results of this study will provide important information for potential future preventive measures and slowdown of PD progression by mimicking the changes in serum iron-binding proteins caused by tobacco smoking without the health hazards caused by smoking, because serum iron levels can be modified by dietary interventions.            ",2588742;,"COSTA-MALLEN, PAOLA;","SUTHERLAND, MARGARET L",02/01/2013,01/31/2015,Age;Anemia;Anemia due to Chronic Disorder;Binding Proteins;Blood - brain barrier anatomy;Blood Tests;Brain;case control;Characteristics;cigarette smoking;Deposition;Diagnosis;Dietary Intervention;Disease Progression;disorder risk;Epidemiology;Ethnicity aspects;Ferritin;Future;Gender;Genetic Polymorphism;Grant;Haptoglobins;Health Hazards;Hemoglobin;Hemoglobin concentration result;Homeostasis;imaging modality;insight;Iron;Iron deficiency anemia;Iron-Binding Proteins;Magnetic Resonance Imaging;Measurement;Measures;men;Methods;Nerve Degeneration;never smoker;novel;Parkinson Disease;Participant;Patients;Pattern;Phenotype;Predisposition;Preventive;Protein Binding;public health relevance;Red Blood Cell Count measurement;Relative (related person);Reproducibility;Research;Risk;Serum;Serum iron level result;Smoker;Smoking;smoking cessation;Smoking Status;Statistical Study;Substantia nigra structure;Testing;Time;Tobacco smoking;Transferrin;Transferrin Receptor;Weight;Woman,Haptoglobin Phenotype and Smoking: Effects on Iron Levels in Parkinson's Disease,70202,CNN,Clinical Neuroscience and Neurodegeneration Study Section,,,2,174226,
8617876,R21,NS,5,N,02/04/2014,02/01/2014,01/31/2015,853,R21NS079317,OVERALL MEDICAL,PA-11-261,5R21NS079317-02,NINDS:173250\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PORTLAND,UNITED STATES,NEUROSCIENCES,03,096997515,US,OREGON HEALTH &SCIENCE UNIVERSITY,OR,972393098,"PUBLIC HEALTH RELEVANCE: This project tests a novel approach for identifying microRNA:mRNA interactions. Characterizing direct targets of microRNAs may help elucidate the mechanisms underlying microRNA control of development, plasticity, and a variety of human neurological/psychiatric diseases.                        ",1883519;,"GOODMAN, RICHARD H.;","RIDDLE, ROBERT D.",02/15/2013,01/31/2015,Address;Aftercare;Algorithms;Attention;Bioinformatics;Biological Assay;Biological Models;Biology;Brain;cell type;Cells;Complex;Data;Data Set;Development;Dominant-Negative Mutation;Epitopes;genome-wide;Hippocampus (Brain);Human;Individual;interest;Laboratories;Link;Luciferases;Mediating;Mental disorders;Messenger RNA;Methods;MicroRNAs;mRNA tagging;mRNA Transcript Degradation;nervous system disorder;Neuroblastoma;neuroblastoma cell;Neuroglia;Neurologic;Neurons;novel;novel strategies;Population;Process;public health relevance;Regulation;relating to nervous system;Reporter;Reporting;Repression;RNA-Binding Proteins;RNA-Induced Silencing Complex;Signal Transduction;Subfamily lentivirinae;System;Testing;Transcript;Western Blotting,A novel method for identifying microRNA targets,79317,MNG,Molecular Neurogenetics Study Section,,,2,173250,
8617881,R21,NS,5,N,02/04/2014,02/01/2014,01/31/2015,853,R21NS082922,SCHOOLS OF ARTS AND SCIENCES,PA-11-261,5R21NS082922-02,NINDS:162000\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOZEMAN,UNITED STATES,ANATOMY/CELL BIOLOGY,00,625447982,US,MONTANA STATE UNIVERSITY - BOZEMAN,MT,59717,"PUBLIC HEALTH RELEVANCE: Adaptation to the fruit fly of a recently developed technique for identifying synaptic contact sites in the mouse will significantly enhance the ability to map neural circuits in the well-established fruit fly model system. This will facilitate our understandng of how the nervous system processes information and will have implications for numerous fly models of both normal nervous system function and human neurological conditions that involve neural circuits including sensory information processing, neurodegenerative disease, addiction, and sleep disorders.                ",1875318;,"STOWERS, RONALD STEVEN;","RIDDLE, ROBERT D.",02/15/2013,01/31/2015,addiction;Behavior;Behavioral;Biological Assay;Biological Models;Chemicals;Cloning;computerized data processing;Drosophila genus;Environment;Exhibits;expression vector;Fluorescence;fly;Generations;Genetic Recombination;Genetic Transcription;Goals;Homologous Gene;Human;improved;Individual;information processing;interest;Knowledge;Maps;Mediating;Medical;Methodology;Methods;Modeling;Modification;Molecular Genetics;Mus;Nerve;Nervous System Physiology;Nervous system structure;neural circuit;Neurobiology;Neurodegenerative Disorders;Neurologic;neuron component;Neurosciences;Organism;Proteins;public health relevance;recombinase;reconstitution;Research;response;Sensory;Signal Transduction;Site;Sleep;Sleep Disorders;Specificity;Synapses;Synaptic Vesicles;System;Techniques;Testing;Translating,Adaptation of a synapse-specific version of GFP Reconstitution Across Synaptic Pa,82922,MNG,Molecular Neurogenetics Study Section,,,2,162000,
8657497,R21,OD,5,N,02/01/2014,02/01/2014,01/31/2015,351,R21OD016562,SCHOOLS OF MEDICINE,PA-10-138,5R21OD016562-02,OD:159947\,Research Projects,2014,"OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH",,SALT LAKE CITY,UNITED STATES,GENETICS,02,009095365,US,UNIVERSITY OF UTAH,UT,84112,"PUBLIC HEALTH RELEVANCE: Glia strongly affect nervous system performance and health, contributing to a wide range of illnesses including Rett syndrome, Alzheimer's disease, Parkinson's disease, epilepsy and OCD. Genetic tools generated in this project will allow investigators studying any of these and other disorders to manipulate and monitor glial activity. This will provide a framework for the development and testing of new therapeutic approaches to disorders involving astrocytes and microglia.            ",9215748;,"TVRDIK, PETR;","MIROCHNITCHENKO, OLEG ",05/01/2013,01/31/2015,Acute;Address;Affect;Alzheimer's Disease;Animal Model;animal model development;Astrocytes;axonal pathfinding;base;Behavior;Binding Sites;Biocompatible Materials;Biological Neural Networks;Brain;Breeding;Calcium;calcium indicator;cell type;Cells;cofactor;combinatorial;Complement;cytokine;design;Detection;Development;Disease;DNA;drug development;drug testing;Dyes;Emerging Technologies;Environment;Enzymes;Epilepsy;Epileptogenesis;Fluorescence Resonance Energy Transfer;Fostering;Fragile X Syndrome;Funding Opportunities;Future;Gated Ion Channel;Generations;Genes;Genetic;Genetic Recombination;Glial Fibrillary Acidic Protein;Glues;Goals;Health;homologous recombination;Human;Image;Imaging technology;in vivo;Individual;Inflammatory;Injection of therapeutic agent;Institutes;Interdisciplinary Study;Internal Ribosome Entry Site;Investigation;Knock-in Mouse;Label;Life;Measurable;Mental Retardation;Microglia;Mission;Modeling;Monitor;mouse genome;mouse model;Multiple Sclerosis;Mus;mutant;National Institute of Drug Abuse;National Institute of Mental Health (U.S.);National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;nervous system disorder;Nervous system structure;neural stimulation;Neuroglia;Neurons;neuropathology;Neurosciences;Neurotransmitter Receptor;novel strategies;novel therapeutic intervention;Obsessive-Compulsive Disorder;Optics;optogenetics;Other Genetics;Outcome;Parkinson Disease;Performance;Physiology;Play;Population;Preparation;Procedures;Proteins;Psyche structure;public health relevance;recombinase;relating to nervous system;Reporter;Research;Research Personnel;research study;response;Rett Syndrome;Rhodopsin;Role;Scanning;Schizophrenia;Seizures;sensor;Series;Signal Transduction;Site;Slice;Specificity;Stimulus;synaptogenesis;System;Tamoxifen;Techniques;Technology;Temporal Lobe Epilepsy;Testing;tool;Transgenic Organisms;transmission process;two-photon;Tyrosine;United States National Institutes of Health;Universities;Utah;Viral;voltage;Work,"Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations",16562,CMBG,Cellular and Molecular Biology of Glia Study Section,,,2,159947,
8603827,R24,AA,5,N,02/01/2014,02/01/2014,01/31/2015,273,R24AA022057,SCHOOLS OF PHARMACY,PAR-09-128,5R24AA022057-02,NIAAA:269543\,Other Research Related,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,AURORA,UNITED STATES,PHARMACOLOGY,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,,1865415;,"VASILIOU, VASILIS;","MURRAY, GARY ",02/01/2013,01/31/2018,4 hydroxynonenal;Abbreviations;Acute;adduct;Affect;Alcohol abuse;Alcohol consumption;Alcohol dehydrogenase;Alcohol dependence;alcohol effect;alcohol research;Alcohols;aldehyde dehydrogenases;Aldehydes;Animal Model;Antioxidants;Biological Process;Breeding;Capital;catalase;Catalytic Domain;chronic alcohol ingestion;Communities;CYP2E1 gene;Cytochrome P450;Development;Disease;DNA;effective therapy;Enzyme Gene;Enzymes;Ethanol;Ethanol Metabolism;Felis catus;Free Radicals;Functional disorder;GCLC gene;Genes;Genetic Polymorphism;Glutamate-Cysteine Ligase;Glutathione;Goals;Hepatocyte;Injury;Intention;Investigation;Knock-out;knockout animal;knockout gene;Knockout Mice;Knowledge;Laboratories;Letters;Mammals;Mediating;Messenger RNA;Mitochondria;Modeling;Molecular;mouse model;Mus;Mutation;Organ;Oxidative Stress;Pathogenesis;Population;Principal Investigator;Proteins;Reactive Nitrogen Species;Reactive Oxygen Species;Reduced Glutathione;Research;Research Personnel;Role;System;Tissues;tool;Toxic effect;Transgenic Animals;Transgenic Mice;Transgenic Organisms,Mouse Models for Alcohol Metabolism and Tissue Injury,22057,ZAA1,Special Emphasis Panel,,,2,269543,
8687737,R24,MD,5,N,02/07/2014,02/01/2014,01/31/2015,375,R24MD001626,ORGANIZED RESEARCH UNITS,RFA-MD-13-001,5R24MD001626-10,NCMHD:465124\,Other Research Related,2014,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,FAIRBANKS,UNITED STATES,NONE,00,615245164,US,UNIVERSITY OF ALASKA FAIRBANKS,AK,997757880,"PUBLIC HEALTH RELEVANCE: Alcohol use disorders and suicide constitute a source of immense health disparity in American Indian/AN communities, where suicide and unintentional injury are the leading cause of death for AN people ages 10 to 39, and alcohol is implicated in a large proportion of these events. This project will provide knowledge on effective and innovative methods for CBPR intervention dissemination and implementation with other culturally distinct ethnic minority, underserved, lower socioeconomic, and rural populations.                 ",11274203;,"RASMUS, STACY M;","DANKWA-MULLAN, IRENE ",09/30/2005,01/31/2016,Accidental Injury;Acculturation;Address;Advocacy;Age;Alaska;Alaska Native;Alcohol abuse;alcohol use disorder;Alcohols;American Indian and Alaska Native;Area;arm;Awareness;Back;base;Boxing;Cause of Death;Clinical Trials Design;Collaborations;Communities;Community Health;community intervention;Development;Educational Curriculum;Effectiveness;efficacy testing;Eskimo Population;ethnic minority population;Evaluation;Event;evidence base;experience;flexibility;Funding;Health;health disparity;Health Priorities;Housing;Human Rights;Incidence;Income;Indigenous;Information Technology;innovation;interest;Intervention;Intervention Studies;Knowledge;knowledge base;Leadership;Life;Logic;member;Metaphor;Methods;Modeling;native youth;Native-Born;Pathway interactions;Personal Satisfaction;Prevention;Principal Investigator;Process;public health relevance;Randomized;Recording of previous events;Reporting;Request for Proposals;Research;Research Personnel;Research Project Grants;Resources;response;Rural Population;skills;sobriety;socioeconomics;Source;staff intervention;Structure;suicidal risk;Suicide;Testing;theories;therapy development;Time;tool;Training;Translations;tribal community;Trust;underage drinking;United States;Universities;Waiting Lists;Work;Writing;Youth;Yup'ik,Qasgiq: Dissemination Using Yup'k Indigenous Implementation Strategies,1626,ZMD1,Special Emphasis Panel,,,10,465124,
8601686,R25,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,R25AA020818,SCHOOLS OF MEDICINE,PAR-11-050,5R25AA020818-03,NIAAA:40460\,Other Research Related,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,OMAHA,UNITED STATES,ADMINISTRATION,02,168559177,US,UNIVERSITY OF NEBRASKA MEDICAL CENTER,NE,681987835," This application will support a ten-week summer research program for seven undergraduate students to work with investigators at the University of Nebraska Medical Center in a program that includes hands-on biomedical research experience and educational programming. Students will work with a group of committed faculty mentors whose research foci are related to alcohol and its effect on human health. The goal of the program is to encourage students, including underrepresented minority and disadvantaged students, to pursue careers in biomedical research.            ",1859186 (contact);8121236;,"KLASSEN, LYNELL W. (contact);ROMBERGER, DEBRA;","JUNG, KATHY ",02/05/2012,01/31/2017,Alcohol abuse;alcohol abuse therapy;alcohol research;Alcohols;Area;base;Biomedical Research;career;Cell physiology;Clinical;Commit;Disadvantaged;Evaluation;experience;Faculty;Funding;Future;Goals;Health;Human;improved;In Vitro;in vivo;interest;Interest Group;Internal Medicine;Journals;Laboratories;Learning;Medical center;member;Mentors;Mind;Minority;National Institute on Alcohol Abuse and Alcoholism;Native Americans;Nebraska;next generation;Organ;Outcome;Participant;Perception;Problem Solving;Process;Program Evaluation;programs;public health medicine (field);Qualifying;Recording of previous events;Recruitment Activity;Research;Research Personnel;Rest;Rural;Science;Series;Students;System;Talents;Training;undergraduate research;undergraduate student;Underrepresented Minority;Universities;Vertebral column;Work,UNMC Summer Undergraduate Alcohol Research Program,20818,AA,Biomedical Research Review Subcommittee,,,3,40460,
8619637,R25,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R25GM066534,EARTH SCIENCES/RESOURCES,PAR-12-056,5R25GM066534-11,NIGMS:340804\,Other Research Related,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BLACKSBURG,UNITED STATES,VETERINARY SCIENCES,09,003137015,US,VIRGINIA POLYTECHNIC INST AND ST UNIV,VA,24061,PUBLIC HEALTH RELEVANCE: The Virginia Tech Post-baccalaureate Research and Education Program (VT-PREP) will train underrepresented students in the biomedical and behavioral sciences so that they become competitive for admission into highly regarded doctoral research programs.                    ,2072581;1922434 (contact);,"SMITH, EDWARD J;WONG, ERIC A (contact);","BENDER, MICHAEL T.",09/01/2002,01/31/2017,Admission activity;Advisory Committees;Authorship;Awareness;Behavioral;Behavioral Sciences;Biological Sciences;Biomedical Research;career;Chicago;Climate;cohort;college;Committee Members;Communities;Development;Development Plans;Discipline;Doctor of Philosophy;Educational aspects;Educational process of instructing;Educational workshop;Enrollment;Ensure;Environment;Event;experience;Faculty;Fellowship;Funding;Goals;Graduate Education;graduate student;improved;Individual;Institution;International;Interview;Manuscripts;meetings;member;Mentors;Minority;Outcome;outreach;peer;Peer Review;Postdoctoral Fellow;Predoctoral Individual National Research Service Award;programs;public health relevance;Publishing;Records;Recruitment Activity;Research;Research Activity;Research Project Grants;Schools;Science;Scientist;social;Students;success;Supervision;symposium;Time;Training;Training Programs;Underrepresented Minority;Universities;Virginia,Virginia Tech Post-baccalaureate Research and Education Program (VT-PREP),66534,BRT,National Institute of General Medical Sciences Initial Review Group,,,11,340804,
8607962,R25,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R25GM078441,SCHOOLS OF ARTS AND SCIENCES,PAR-07-432,5R25GM078441-08,NIGMS:321285\,Other Research Related,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LAWRENCE,UNITED STATES,BIOLOGY,02,076248616,US,UNIVERSITY OF KANSAS LAWRENCE,KS,660457568,"NARRATIVE / RELEVANCE  The proposed project will increase the diversity of the scientific community by preparing American Indians and other underrepresented students for graduate study and eventual careers in biomedical research. The project will increase the size and diversity of the scientific workforce and increase interest in research regarding  diseases with a high incidence in minority populations, improving both health care and disease prevention in this country.",9754774;6078595 (contact);,"GAVOSTO, ESTELA A.;ORR, JAMES A. (contact);","BENDER, MICHAEL T.",09/30/2006,01/31/2015,"Address;Admission activity;American Indians;Area;Bachelor's Degree;base;Behavior;Biomedical Research;career;Communities;Competence;Comprehension;Contracts;Country;Critiques;design;Development;Development Plans;Discipline;Disease;disorder prevention;Doctor of Philosophy;Educational aspects;Educational workshop;Elements;Enrollment;Equilibrium;Evaluation;expectation;experience;Faculty;falls;Fellowship;Focus Groups;Funding;Goals;graduate student;health disparity;Healthcare;Human Resources;Immersion Investigative Technique;improved;Incidence;Individual;innovation;Institution;interest;Kansas;Knowledge;Laboratories;Laboratory Research;Leadership;Life;Mathematics;Measurable;Measures;meetings;Mentors;Minority;Modification;NCI Scholars Program;Outcome;Paper;Performance;Population;Preparation;Program Evaluation;programs;Publications;Questionnaires;Reading;Recruitment Activity;Reporting;Research;Research Personnel;Research Project Grants;Research Training;response;responsible research conduct;Sampling;Schools;Science;Scientist;Secure;Series;skills;Specialist;Specific qualifier value;Students;success;symposium;Testing;Thinking, function;Time;Training;tribal college;Underrepresented Minority;United States National Institutes of Health;Universities;Work;Writing",KU Post-Baccalaureate Research Education Program (PREP),78441,MPRC,Minority Programs Review Subcommittee B,,,8,321285,
8610322,R25,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R25GM086304,SCHOOLS OF ARTS AND SCIENCES,PAR-07-432,5R25GM086304-04,NIGMS:305545\,Other Research Related,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,CHEMISTRY,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472," The goal of the UW PREP is to annually recruit eight students from an underrepresented background to a post- baccalaurate program that will prepare them for success in graduate school in the biomedical sciences. The trainees will engage in a one-year intensive research project in a field of interest, under the supervision of two faculty mentors with complementary expertise. The students will also receive training in scientific writing and communication. We anticipate that all of the trainees will apply for admission into graduate school, during their tenure in the program and at least 75% of them will be accepted. A rigorous set of indicators will be employed to evaluate the long-term success of the program.",6796033;,"VARANI, GABRIELE;","BENDER, MICHAEL T.",02/14/2011,01/31/2015,Address;Admission activity;Bachelor's Degree;Behavioral;Biological Sciences;Biomedical Research;career;Clinical;college;Commit;Communication;Complex;Development;Disabled Persons;Doctor of Medicine;Doctor of Philosophy;doctoral student;Economically Deprived Population;Educational aspects;Enrollment;Ensure;Evaluation;Evaluation Research;experience;Faculty;Failure (biologic function);Fostering;Foundations;Fred Hutchinson Cancer Research Center;Funding;Goals;health disparity;Institution;instrument;interdisciplinary approach;interest;Journals;Laboratories;Laboratory Research;Literature;Measures;meetings;Mentors;Mentorship;Minority;Minority Groups;Modification;Monitor;Oral;Paper;Population;Postdoctoral Fellow;posters;Preparation;Program Effectiveness;programs;public health relevance;Qualifying;Recruitment Activity;Research;Research Personnel;Research Project Grants;Resolution;Schools;Science;Scientist;skills;social;Students;success;Supervision;Training;Training Programs;Underrepresented Minority;United States;Universities;Washington;Writing,UW Post-Baccalaureate Research Education Program (PREP),86304,MPRC,Minority Programs Review Subcommittee B,,,4,305545,
8643269,R25,GM,5,N,02/06/2014,02/01/2014,01/31/2015,859,R25GM105608,,PA-11-351,5R25GM105608-02,NIGMS:154095\,Other Research Related,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ALAMOS,UNITED STATES,,03,801181467,US,"NEW MEXICO CONSORTIUM, INC.",NM,87544,"PUBLIC HEALTH RELEVANCE: Many future biomedical and biotechnological advances in synthetic and systems biology will require investigators who have the ability to carefully integrate quantitative experimentation with mathematical, statistical and computational modeling. The goal of the q-bio Summer School is to prepare a new generation of quantitative biologists who are adept at modeling and/or working with modelers to advance our predictive understanding of cellular regulatory systems. The complexity and importance of these systems, which govern cellular activities and fates, provides motivation for developing a scientific and engineering workforce equipped to deal with the complexity.            ",7622867;11414861;11414849 (contact);9749522;,"HASTY, JEFF M;HLAVACEK, WILLIAM;MUNSKY, BRIAN  (contact);TSIMRING, LEV S;","LYSTER, PETER ",04/01/2013,01/31/2017,Behavior;biochemical model;Bioinformatics;Biological;biological research;Biology;career;Career Choice;career development;Cell model;Cell physiology;Cells;Chemistry;Communication;Communities;Complex;computational neuroscience;Computational Technique;Computer Simulation;Computer software;computerized tools;Computers;Computing Methodologies;Cues;Data;demographics;Educational aspects;Educational Background;Educational Curriculum;Educational workshop;Engineering;Ethnicity aspects;Event;Exposure to;Financial Support;Funding;Future;Gender;Gene Expression Regulation;Generations;Goals;graduate student;Heterogeneity;Immune system;improved;Individual;Institution;interest;International;Internet;lecture notes;lecturer;lectures;Machine Learning;mathematical model;Mathematics;member;Mentors;Minority-Serving Institution;model design;Modeling;Molecular;Motivation;multidisciplinary;National Institute of General Medical Sciences;Neurons;Occupations;Participant;peer;physical science;Physics;Population;Postdoctoral Fellow;posters;predictive modeling;programs;public health relevance;Qualifying;Race;Reporting;Research;Research Personnel;research study;Resources;response;Schools;Scientist;Series;Signal Transduction;simulation;skills;Social Network;Statistical Data Interpretation;Statistical Models;statistics;Students;symposium;synthetic biology;Synthetic Genes;System;Systems Biology;Techniques;Time;tool;Training;United States National Institutes of Health;Viral;Woman;Work,The q-bio Summer School,105608,MABS,Modeling and Analysis of Biological Systems Study Section,,,2,154095,
8605904,R25,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,R25HL084665,SCHOOLS OF MEDICINE,RFA-HL-10-013,5R25HL084665-09,NHLBI:102716\,Other Research Related,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"The NHLBI Short-Term Research Education Program to Increase Diversity in Health- Related Research at the University of Pennsylvania School of Medicine provides undergraduate students and research-oriented medical students from diverse, underrepresented backgrounds with a short-term, intensive summer research experience with the goal of increasing the pool of underrepresented students committed to careers in cardiovascular, pulmonary, and hematologic research.",1887533 (contact);1898979;,"DELISSER, HORACE M (contact);SULLIVAN, KATHLEEN E;","CHANG, HENRY ",05/01/2006,01/30/2016,"Adopted;Affect;Area;base;biobehavior;Biochemistry;Biological;Biological Process;biological systems;Biophysics;Blood;Cancer Education Grant Program;Cardiovascular Diseases;Cardiovascular system;career;career development;Clinical;college;Commit;Communicable Diseases;Data;Disabled Persons;Disadvantaged;Discipline;Disease;Educational aspects;Educational workshop;experience;Experimental Designs;Faculty;Funding;Genetic;Goals;Grant;Health;Heart;Hematopoiesis;Hemoglobinopathies;Hemostatic function;Immune System Diseases;Immunology;Individual;interest;Investigation;Journals;Laboratories;Laboratory Research;Lung;Lung diseases;medical schools;Medical Students;meetings;Mentors;Microbiology;Molecular;Molecular and Cellular Biology;National Heart, Lung, and Blood Institute;Neurosciences;Organ;Participant;peer;Pennsylvania;Physiology;Problem Formulations;Process;programs;prospective;Qualifying;Reading;Research;Research Training;responsible research conduct;Schools;Science;Series;Sickle Cell Anemia;skills;structural biology;Structure;Students;Testing;Thrombosis;Time;Training;undergraduate research;undergraduate student;Underrepresented Minority;Universities;university student;virology;Work",ST Research Education Program to Increase Diversity in Health Related Research,84665,ZHL1,Special Emphasis Panel,,,9,102716,
8607592,R25,HL,5,N,02/06/2014,02/01/2014,01/31/2015,837,R25HL115473,,RFA-HL-12-031,5R25HL115473-03,NHLBI:153576\,Other Research Related,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BETHESDA,UNITED STATES,,08,064856685,US,AMERICAN PHYSIOLOGICAL SOCIETY,MD,20814,"  Project Narrative  APS STRIDE: Promoting Diversity Through Research Experiences and Professional Socialization With the urgent need for research on diseases such as cardiovascular, pulmonary, hematologic, and sleep disorders research, the need to attract and retain future biomedical researchers is acute. Toward that end, building career interest and research skills among students from groups traditionally underrepresented in biomedicine (e.g., from disadvantaged backgrounds and certain racial and ethnic groups and individuals with disabilities) is critical to the future of US health. The APS STRIDE project will help undergraduate students from groups underrepresented in biomedicine to 1) increase their understanding of and exposure to careers in biomedical research, 2) experience biomedical research in an NHLBI-related area, 3) develop their research and presentation skills, and 4) become part of the professional research community (professional socialization). Research experiences are pivotal in the development of future scientists and the STRIDE program will facilitate the career development of a new generation of biomedical researchers.  ",9813796;9813799;1903431 (contact);,"BRUTHERS, CHERYL BROOKE;LOWY, MELINDA E.;MATYAS, MARSHA LAKES (contact);","CARLSON, DREW E",08/21/2012,01/31/2017,"abstracting;Acute;Advocate;aluminum sulfate;Archives;Area;Biomedical Research;Cardiovascular system;career;career development;Collaborations;Collection;Committee Members;Communities;Data;Data Reporting;Development;Digital Libraries;disability;Disadvantaged;Disease;Educational aspects;Educational process of instructing;Ethical Issues;Ethnic group;experience;Exposure to;Fellowship;Female;Funding;Future;Generations;Goals;Graduate Education;Health;Individual;Institution;interest;Laboratories;Learning;Learning Disabilities;Lung;male;Manuscripts;Measurable;meeting abstracts;Mentors;Mission;National Heart, Lung, and Blood Institute;posters;programs;Publications;Race;Recruitment Activity;Reporting;Research;Research Personnel;research study;Research Training;Resources;responsible research conduct;Scientist;skills;Sleep Disorders;Socialization;Societies;Structure;Students;Surveys;Training;undergraduate student;Woman;Work;Writing",APS Short-Term Research Education Program to Increase Diversity in Health-Related,115473,ZHL1,Special Emphasis Panel,,,3,153576,
8656429,R25,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,R25HL118679,SCHOOLS OF MEDICINE,RFA-HL-13-020,5R25HL118679-02,NHLBI:65739\,Other Research Related,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212," Narrative: This program is dedicated to an important societal goal, namely increasing the number of UR undergraduate students who will enter graduate programs in the biomedical sciences, medical or dental schools, or other health related programs such as public health. This program will prepare them for graduate work with an extensive, creative, and carefully mentored summer research and training program. The result will be to increase the number of these individuals entering into all areas of graduate and professional schools and thus increasing their presence in all areas of the biomedical workforce.",8014766;,"PATTON, JAMES G.;","CARLSON, DREW E",04/26/2013,01/31/2018,abstracting;Area;Biomedical Research;Cardiovascular system;career;Clinic Visits;Dental;Dental Schools;design;Diabetes Mellitus;Disease;Educational aspects;experience;Goals;graduate student;Health;Healthcare;Hypertension;Individual;interest;Lung;Medical;medical schools;meetings;Mentors;Minority;minority health;Obesity;Physicians;programs;public health medicine (field);Qualifying;Research;Research Training;Schools;Science;Training Programs;undergraduate student;Work,Short-Term Training Program to Increase Diversity in Health-Related Research,118679,ZHL1,Special Emphasis Panel,,,2,65739,
8723877,R25,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,R25HL118693,SCHOOLS OF MEDICINE,RFA-HL-13-020,5R25HL118693-02,NHLBI:139289\,Other Research Related,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,604483045,US,BOSTON UNIVERSITY MEDICAL CAMPUS,MA,021182340, Summer Research and Educational Program (SREP) is a program designed to provide a summer research experience for underrepresented minority students who are currently in the EMSSP program at BUSM or undergraduate students from various national and international colleges and universities. The program is comprised of both a research component as well as an educational component. The students will be mentored by a team approach and the program evaluated annually with feedback from all student and faculty participants.,1872773;,"CRUIKSHANK, WILLIAM W;","CARLSON, DREW E",08/20/2013,01/31/2018,abstracting;Address;Area;Asthma;base;Blood;Blood Vessels;Boston;Cardiology;career;Clinical Sciences;college;Data;design;Development;Diabetes Mellitus;disability;Disadvantaged;Disease;Doctor of Philosophy;Economics;Environment;environmental enrichment for laboratory animals;Evaluation Research;experience;Exposure to;Faculty;Feedback;Fostering;Foundations;Future;Goals;Growth;Heart;Hypertension;Individual;Institutes;Institution;International;Journals;Laboratories;Lung;medical schools;meetings;Mentors;Oral;Participant;Pneumonia;Positioning Attribute;posters;Program Evaluation;programs;Qualifying;Reading;Recruitment Activity;Research;role model;Schools;Science;Scientist;social;Students;success;symposium;Training;Training Programs;translational approach;Translational Research;undergraduate research;undergraduate student;Underrepresented Minority;Universities;web site,Summer Research and Educational Program,118693,ZHL1,Special Emphasis Panel,,,2,139289,
8610883,R37,AR,5,N,02/06/2014,02/01/2014,01/31/2015,846,R37AR055099,SCHOOLS OF MEDICINE,PA-10-067,5R37AR055099-30,NIAMS:354797\,Research Projects,2014,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BALTIMORE,UNITED STATES,BIOCHEMISTRY,07,188435911,US,UNIVERSITY OF MARYLAND BALTIMORE,MD,212011508," Release of calcium ions from their intracellular storage location in skeletal muscle due to muscle fiber depolarization is a prerequisite for all skeletal muscle activity, including that involved in locomotion and breathing. Here we identify and study a previously unsuspected drastic suppression of muscle calcium release during depolarization of muscle fibers from a mouse genetically engineered to have one of the mutations responsible for hypokealemic periodic paralysis in humans. We also identify a previously unrecognized interaction of 2 proteins, calmodulin and S100A1, in modulation of both calcium release and L-type calcium channels that could influence muscle activation in both generalized or muscle-specific disease states, or in aging muscle.         ",1857644;,"SCHNEIDER, MARTIN F;","BOYCE, AMANDA T.",07/01/1985,01/31/2017,Action Potentials;Adult;Affinity;Aging;Binding (Molecular Function);Binding Proteins;Binding Sites;Breathing;C-terminal;Calcium;Calcium ion;Calmodulin;Cells;Charge;Collaborations;combat;Competitive Binding;Coupled;Coupling;Culture Techniques;Defect;Deterioration;Dihydropyridine Receptors;Discipline;Disease;Egtazic Acid;electric field;Exhibits;Fiber;Fluo 4;Genetically Engineered Mouse;Goals;Grant;Health;Human;Hypokalemic periodic paralysis;Image;Impairment;innovation;Investigation;L-Type Calcium Channels;Ligands;Link;Location;Locomotion;Measurement;Mediating;Membrane;Molecular;Monitor;mouse model;Movement;Mus;Muscle;muscle aging;Muscle Fibers;Muscle function;Mutate;Mutation;Myopathy;novel;Optics;Paralysed;Pathologic;peptide structure;Peptides;Preparation;Process;protein expression;protein structure;Proteins;Reagent;Respiration;Role;Ryanodine Receptor Calcium Release Channel;RyR1;Sarcoplasmic Reticulum;Scanning;sensor;Signal Transduction;Site;Skeletal muscle structure;small hairpin RNA;small molecule;Solutions;Speed (motion);Structure;Tail;Techniques;Testing;Training;Transgenic Animals;Transgenic Mice;voltage;voltage clamp,"Roles of voltage sensor, S100A1 and calmodulin in skeletal muscle Ca2+ signaling",55099,SMEP,Skeletal Muscle Biology and Exercise Physiology Study Section,,,30,354797,
8613317,R37,EB,5,N,02/07/2014,02/01/2014,01/31/2015,286,R37EB002784,SCHOOLS OF ARTS AND SCIENCES,,5R37EB002784-39,NIBIB:179956\,Research Projects,2014,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,STANFORD,UNITED STATES,BIOSTATISTICS &OTHER MATH SCI,18,009214214,US,STANFORD UNIVERSITY,CA,943056203,,1968853;,"EFRON, BRADLEY;","PENG, GRACE ",01/15/1993,01/31/2015,Age;Age of Onset;Algorithms;aptamer;Area;Award;Biomedical Research;cancer microarray;Chromosomes;Complex;Computer Assisted;Data;Data Set;Development;Devices;Diagnostic Procedure;Emerging Technologies;Equipment;Exons;Gender;Genes;Goals;Hypertension;Imaging Device;Individual;insight;Laws;Literature;Medical;Medicine;Methodology;Methods;Methylation;Modems;Nature;Paper;Probability;Progress Reports;Research Project Grants;Sample Size;Scientist;sound;Spottings;Statistical Methods;Taxes;Techniques;Testing;theories;Trees;Ursidae Family;Work,Adaptation of New Statistical Ideas for Medicine,2784,NSS,No Study Section (in-house review),,,39,179956,
8606854,R37,GM,5,N,02/03/2014,02/01/2014,01/31/2015,859,R37GM046255,SCHOOLS OF ARTS AND SCIENCES,,5R37GM046255-23,NIGMS:340178\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,BIOSTATISTICS &OTHER MATH SCI,07,605799469,US,UNIVERSITY OF WASHINGTON,WA,981959472,"Complex traits including cardiovascular, neurological and behavioral phenotypes are related to human health  disorders which carry a significant public health burden. Identification of genes contributing to increased  disease risk has been limited by trait complexity. Development of methods for genetic analysis offers the  potential for finding the genes contributing to risk, and for resolving the interaction of genes and environment.",1876807;,"THOMPSON, ELIZABETH ALISON;","KRASNEWICH, DONNA M",09/01/1991,01/31/2018,Area;base;Behavior Disorders;Behavioral;Cardiovascular Diseases;Cardiovascular system;Complex;Complex Genetic Trait;Computer software;Computing Methodologies;Data;data modeling;Data Set;Detection;Development;Disease;disorder risk;DNA Sequence;Documentation;gene environment interaction;Gene Frequency;Genes;Genetic;genetic analysis;genetic epidemiology;genetic linkage analysis;Genetic Markers;genetic pedigree;Genome;genome-wide;Genomics;Genotype;Haplotypes;Health;Human;improved;Individual;Joints;Linkage Disequilibrium;Location;Markov Chains;Measures;method development;Methodology;Methods;Modeling;Monte Carlo Method;Neurologic;next generation sequencing;novel strategies;Pattern;Phenotype;public health medicine (field);Research;Resolution;Risk;Sampling;segregation;Simulate;simulation;Statistical Methods;Structure;technique development;Techniques;trait;Uncertainty;Variant,Methods for the Genetic Epidemiology of Complex Traits,46255,NSS,No Study Section (in-house review),,,23,340178,
8613507,R37,MH,5,N,02/04/2014,02/01/2014,01/31/2015,242,R37MH087027,SCHOOLS OF ARTS AND SCIENCES,PA-07-070,5R37MH087027-05,NIMH:370810\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,CAMBRIDGE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001425594,US,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,MA,02139,"PUBLIC HEALTH RELEVANCE: We will use multiple-electrode technology to record from multiple areas of the cortex while monkeys attend to make decisions about, different stimulus features. Testing these hypotheses is critical step to addressing neuropsychiatric disorders. There is increasing evidence that many disorders may be due to dysfunction in connections and interactions between brain areas. This study would be the first large scale test of how interactions between cortical areas support two basic and critical cognitive functions.         ",1908959;,"MILLER, EARL K;","ROSSI, ANDREW ",03/11/2010,01/31/2015,Acute;Address;Area;area V4;Attention;Attention deficit hyperactivity disorder;Brain;Cognition;Cognitive;cognitive function;Color;Data;Decision Making;design;Dimensions;Disease;Electrodes;Failure (biologic function);feeding;frontal lobe;Functional disorder;Implant;implantation;Individual;Inferior;insight;Investigation;Judgment;lateral intraparietal area;Learning;Monkeys;Motion;Motor;Nature;Neurons;neurophysiology;neuropsychiatry;Parietal Lobe;Pattern;Perception;Play;Prefrontal Cortex;public health relevance;relating to nervous system;Role;Schizophrenia;Sensory;sensory cortex;Signal Transduction;Source;Stimulus;Technology;Temporal Lobe;Testing;theories;Time;Training;Visual;Visual Cortex;Visual Motion;Work,Cortical Circuits for Attention and Decisions,87027,ZRG1,Special Emphasis Panel,,,5,370810,
8644806,R44,GM,5,N,02/06/2014,02/01/2014,01/31/2015,859,R44GM103389,,PA-07-451,5R44GM103389-05,NIGMS:372453\,SBIR-STTR,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NORTH POTOMAC,UNITED STATES,,06,193771347,US,"POTOMAC AFFINITY PROTEINS, LLC",MD,20878," PROJECT NARRATIVE The complex and dynamic nature of proteomes make them rich with useful information but difficult to characterize. Our long-range objective is to develop a sophisticated set of protease tools to facilitate proteomic analysis in the way restriction endonucleases have facilitated genomic analysis. Better proteomic tools will lead to earlier detection of disease states, better treatments, better predictability of the effects of various treatments, and the development of individualized therapies.",8384872;,"RUAN, BIAO;","SOMERS, SCOTT D.",05/01/2009,01/31/2015,Affinity;Bacillus (bacterium);base;Chimeric Proteins;commercial application;Complex;Consensus;Dimensions;directed evolution;Disease;DNA Restriction Enzymes;Early Diagnosis;Engineering;Escherichia coli Proteins;Frequencies (time pattern);Funding;Generations;Genetic;Genomics;Grant;handbook;innovation;Lead;Marketing;Methodology;Methods;Nature;novel;Peptide Hydrolases;Phage Display;Phase;Proteins;Proteome;Proteomics;prototype;public health relevance;Random Allocation;Resolution;Resources;Sampling;Site;Slice;Small Business Innovation Research Grant;Specificity;Subtilisins;System;technological innovation;Technology;Testing;therapy development;tool;United States National Institutes of Health;Urea;Work,Engineered proteases for proteomics,103389,ZRG1,Special Emphasis Panel,,,5,372453,
8625842,R44,TR,5,N,02/05/2014,02/01/2014,01/31/2015,350,R44TR000030,,PA-11-096,5R44TR000030-03,NCATS:383615\,SBIR-STTR,2014,NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES,,Smithfield,UNITED STATES,,01,011787640,US,"MJ DATA CORPORATION, LTD",RI,02917," The Data Expediter Syntax Generator software application offers health, social, and education researchers a practical, cost-effective solution for managing, rapidly processing and documenting study data utilizing technology that makes these high-value activities readily transparent. The product has the potential to decrease data and reporting errors, increase data quality, improve research study efficiency, and enhance data sharing.            ",8466676;,"MINUGH, P ALLISON;","SAWCZUK, ANDREA ",08/15/2012,01/31/2015,Accountability;Address;Administrator;Affect;Algorithms;Archives;Automation;Businesses;Computer software;Computerized Patient Records;Contractor;cost effective;Data;Data Analyses;Data Collection;Data Files;data management;Data Quality;Data Reporting;Data Set;Databases;Decision Making;design;Development;Documentation;Educational aspects;Electronics;Ensure;Focus Groups;Generations;Government;Health;Housing;improved;innovation;Marketing;Metadata;Mind;Modeling;Monitor;Occupations;Outcome;Phase;Practice Guidelines;pressure;Procedures;Process;Production;prototype;Publications;Publishing;Quality Control;Reporting;Research;Research Personnel;research study;Science;sharing data;social;Solutions;sound;Sum;syntax;System;Technology;Testing;Time;tool;Training;Universities;usability;user-friendly;Walking;Work,"Expediting the Production of High Value, Standardized, and Transparent Data",30,ZRG1,Special Emphasis Panel,,,3,383615,
8610325,SC3,GM,5,N,02/01/2014,02/01/2014,01/31/2015,859,SC3GM099632,SCHOOLS OF ARTS AND SCIENCES,PAR-08-028,5SC3GM099632-03,NIGMS:97875\,Other Research Related,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,BIOLOGY,02,108109182,US,CHICAGO STATE UNIVERSITY,IL,606281598," Grant Title: Gut Circadian Clock and Melatonin Dynamics Following Major Thermal Injury Narrative: This project uses an established animal model for major burn injury to investigate the dynamics of postburn intestinal sepsis pathogenesis using cellular and molecular tools. It makes use of recent findings on the effects of melatonin and chronic irregular sleep or jetlag on gut inflammation and leakiness. Because sepsis is intimately linked to systemic inflammatory response syndrome, this project is of great significance to many inflammation-based human disorders, such as inflammatory bowel disease (IBD).            ",2109329;,"AL GHOUL, WALID M;","KRASNEWICH, DONNA M",02/22/2012,01/31/2016,abstracting;Academic Medical Centers;Address;Affect;Alcohols;Animal Model;Anti-inflammatory;Anti-Inflammatory Agents;Area;Bacteria;Bacterial Toxins;base;Burn injury;Burn Trauma;career;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chicago;Chronic;circadian pacemaker;Circadian Rhythms;Collaborations;combat;cost;Critical Care;Data;Development;Disease;Distal part of ileum;Educational process of instructing;Environment;Enzymes;Evaluation;falls;Functional disorder;Funding;Future;Gastroenterology;gastrointestinal epithelium;Goals;Grant;Health Services Research;heat injury;Human;Immunohistochemistry;improved;In Situ;In Situ Hybridization;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory disease of the intestine;Inflammatory Response;Injury;innovation;Institution;Intensive Care Units;Intestines;Jet Lag Syndrome;Light;Link;Literature;Lymph;Mainstreaming (Education);Measurement;Medical;Melatonin;Mentors;Metabolic;Minority;Modeling;Molecular;molecular dynamics;molecular marker;Mucous Membrane;Multiple Organ Failure;novel;Paper;Pathogenesis;Patients;Performance;Peripheral;Pharmaceutical Preparations;Principal Investigator;Production;Publications;Publishing;Regimen;Reporting;Research;Scholarship;Sepsis;Sepsis Syndrome;Septicemia;Site;Sleep;Sleep Deprivation;Source;spatiotemporal;Testing;Time;Tissues;tool;United States;Universities;Vital Statistics;Work,Gut Circadian Clock and Melatonin Dynamics Following Major Thermal Injury,99632,ZGM1,Special Emphasis Panel,,,3,97875,
8661188,T32,EY,5,N,02/05/2014,02/01/2014,01/31/2015,867,T32EY021453,SCHOOLS OF MEDICINE,RFA-EY-10-001,5T32EY021453-04,NEI:135784\,"Training, Institutional",2014,NATIONAL EYE INSTITUTE,,NASHVILLE,UNITED STATES,PHYSIOLOGY,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212, This training program will provide training into statistical genetics and genome bioinformatics for both pre-doctoral and post-doctoral fellows. They will have an integrated training environment providing specific training in both the clinical and genomic aspects of quantitative ocular phenotypes.,8017255;,"BRANTLEY, MILAM A.;","AGARWAL, NEERAJ ",02/01/2011,01/31/2016,Genomics;Training Programs,Training Program in Quantitative Ocular Genomics,21453,ZEY1,Special Emphasis Panel,,,4,135784,
8601673,U01,AA,5,N,02/01/2014,02/01/2014,01/31/2015,273,U01AA013499,SCHOOLS OF MEDICINE,RFA-AA-11-006,5U01AA013499-13,NIAAA:209066\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,MEMPHIS,UNITED STATES,ANATOMY/CELL BIOLOGY,09,941884009,US,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,TN,38163," RELEVANCE (See instructions): This U01 project of INIAStress will be of high significance in understanding at least two critical features of alcoholism: (1) the underlying genetics and neurogenetics of susceptibility to stress and alcohol, and (2) the imprints of allostatic load on gene expression (including alternative isoform usage and production of noncoding RNAs) in different CNS regions and in strains with markedly different responses to alcohol and stress.         ",1863522;,"WILLIAMS, ROBERT W.;","REILLY, MATTHEW ",02/01/2002,01/31/2017,Air;Alcohol consumption;alcohol effect;alcohol exposure;alcohol response;Alcoholism;Alcohols;Alleles;allostasis;allostatic load;Animal Model;Bayesian Analysis;Behavior;binge drinking;Bioinformatics;Brain;Brain region;Breeding;Candidate Disease Gene;cell type;Chronic;cohort;Collaborations;Complex;Consumption;Coupling;Data;Data Set;DNA Sequence;endophenotype;Ethanol;Event;Exons;Exposure to;Family;Family member;Foundations;Functional RNA;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic screening method;Genomics;Grant;Human;human data;Human Genetics;imprint;improved;Inbred Strains Mice;Individual Differences;Instruction;Joints;Knock-out;Left;Link;Mediating;member;Messenger RNA;Methods;Modeling;Modification;Molecular;Molecular Genetics;Molecular Profiling;Molecular Target;Mouse Strains;Mus;neural circuit;Neurobiology;neurogenetics;neurophysiology;Neurotransmitters;nonhuman primate;Organ;Orthologous Gene;Pathway Analysis;Pharmacology;Physiology;Population;Predisposition;Production;protein expression;Protein Isoforms;Proteins;Relapse;response;RNA Sequences;RNA Splicing;Spliced Genes;Stress;Stress Tests;System;Technology;Testing;Tissues;tool;Transcript;transcriptome sequencing;Translating;translational approach;translational study;Untranslated RNA;Variant;Weight,Systems Genetics of Alcohol Response and Stress Effects in CNS,13499,ZAA1,Special Emphasis Panel,,,13,209066,
8606715,U01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,U01AA013510,SCHOOLS OF MEDICINE,RFA-AA-11-006,5U01AA013510-14,NIAAA:439607\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PORTLAND,UNITED STATES,OTHER BASIC SCIENCES,03,096997515,US,OREGON HEALTH &SCIENCE UNIVERSITY,OR,972393098," Alcoholism is the third leading preventable cause of death in the U.S.A. At present, the role of stress in prompting some individuals to drink alcohol excessively is not known. Because monkeys, like humans, voluntarily drink to dependence and share 95% of our genetic makeup, they are excellent human surrogates to discover how stress regulates alcoholic drinking and thereby find more effective treatments for alcoholism.         ",1895150;,"GRANT, KATHLEEN A;","GRANDISON, LINDSEY ",02/15/2002,01/31/2017,Abstinence;Address;Age;alcohol abstinence;alcohol availability;Alcohol consumption;Alcoholism;Alcohols;allostasis;Anxiety;base;Behavior;Behavioral;biological adaptation to stress;Brain;brain metabolism;Cause of Death;Characteristics;Chronic;Chronic Alcoholic Intoxication;Chronic stress;Collaborations;Consumption;Data;Data Set;Dependence;Disease;Dose;drinking;effective therapy;Electrophysiology (science);Endocrine;Environment;Epigenetic Process;Ethanol;Female;flexibility;Funding;Genes;Genetic;genetic pedigree;Heavy Drinking;Homeostasis;Human;human subject;Individual;Intake;Intoxication;Link;Macaca;Macaca fascicularis;Macaca mulatta;Magnetic Resonance Imaging;male;Measures;Metabolic;Modeling;Monkeys;Network-based;neural circuit;neurochemistry;neurogenetics;neurophysiology;Neurosciences;Neurosecretory Systems;neurosteroids;Neurotransmitters;nonhuman primate;novel;Oregon;Organism;Pattern;Peptides;Physiological;Physiology;Population;Population Study;Primates;problem drinker;Productivity;Recovery;Recruitment Activity;Regulation;Relapse;relating to nervous system;Research;Research Design;response;Risk;Rodent;Role;Schedule;Self Administration;Self-Administered;sex;Spectrum Analysis;Stress;Study Subject;Synapses;System;Tissues,INIA:  Stress and Ethanol Self-Administration in Monkeys,13510,ZAA1,Special Emphasis Panel,,,14,439607,
8602759,U01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,U01AA013514,SCHOOLS OF MEDICINE,RFA-AA-11-006,5U01AA013514-13,NIAAA:224300\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,NASHVILLE,UNITED STATES,ANESTHESIOLOGY,05,004413456,US,VANDERBILT UNIVERSITY MED CTR,TN,37212," The Gene-Targeted Mouse Core creates novel inducible-knockout mouse models for INIA-stress investigators and ultimately for the larger research community. The targets, selected by the INIA-stress consortium are receptors or their ligands that play key roles in modulating biological attributes such as anxiety, reward, and emotional behavior. The use of targeted gene disruption allows the dissection of individual pathways in relationship to alcohol consumption and alcoholism.         ",1857949;,"DELPIRE, ERIC J;","REILLY, MATTHEW ",01/01/2002,01/31/2017,Affect;Alcohol abuse;Alcohol consumption;Alcohol Phenotype;Alcoholism;Alleles;Animal Model;Anxiety;base;Behavior;Biological;Birth;blastocyst;Brain;Breeding;Bypass;Chronic;Communities;Development;Dissection;Doxycycline;Embryo;embryonic stem cell;Emotional;Engineering;Enterobacteria phage P1 Cre recombinase;ES Cell Line;Ethanol;European;Exons;feeding;Gene Targeting;Genes;Genetic Recombination;Genotype;Goals;Heavy Drinking;Individual;Injection of therapeutic agent;Knock-out;Knockout Mice;Ligands;mouse model;Mus;Neuroanatomy;novel;Partner in relationship;Pathway interactions;Phenotype;Play;Promotor (Genetics);Prosencephalon;Psychological reinforcement;Quality Control;Reagent;receptor;recombinase;Research;Research Personnel;Rewards;Services;Shipping;Ships;Site;sperm cell;Stress;Tail;Techniques;Technology;Transgenes;Transgenic Mice;vector,Gene-Targeted Mouse Core,13514,ZAA1,Special Emphasis Panel,,,13,224300,
8606716,U01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,U01AA013641,SCHOOLS OF MEDICINE,RFA-AA-11-006,5U01AA013641-14,NIAAA:492666\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PORTLAND,UNITED STATES,OTHER BASIC SCIENCES,03,096997515,US,OREGON HEALTH &SCIENCE UNIVERSITY,OR,972393098," Stress and anxiety have long been implicated in the development of harmful drinking, its escalation to alcoholism and relapse to drinking following a period of abstinence. The INIAstress consortium uses a state-of-the-art translational approach (mice, monkeys and humans) to understand the complex interaction of stress and excessive drinking and identify novel, effective and tailored treatment strategies for alcoholism.         ",1895150;,"GRANT, KATHLEEN A;","NORONHA, ANTONIO ",02/01/2002,01/31/2017,Abstinence;Alcohol consumption;alcohol effect;alcohol exposure;Alcoholism;Alcohols;allostasis;Amygdaloid structure;Animal Model;Anxiety;Area;Beds;Behavioral;biological adaptation to stress;Brain;Cell Nucleus;Chronic;Complex;Corpus striatum structure;Data;Development;Dorsal;drinking;Endocrine;Ethanol;Exposure to;forging;Genetic;Genomics;Goals;Grant;Heavy Drinking;Homeostasis;Human;Individual;Individual Differences;interest;Leadership;Link;Mediating;Monkeys;Motor;multidisciplinary;Mus;neurochemistry;Neurosciences;Neurosecretory Systems;neurosteroids;novel;Nucleus Accumbens;Physiological;Physiological Adaptation;Pilot Projects;Play;Prefrontal Cortex;Process;Recruitment Activity;Regulation;Relapse;relating to nervous system;Research;Research Activity;Research Personnel;response;Risk;Role;Stress;stressor;stria terminalis;Structure;Synapses;System;TNFRSF5 gene;translational approach;treatment strategy;Variation (Genetics),"INIA:  Stress, Anxiety and Excessive Alcohol Drinking (Administrative Core)",13641,ZAA1,Special Emphasis Panel,,,14,492666,
8607102,U01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,U01AA014095,SCHOOLS OF MEDICINE,RFA-AA-11-006,5U01AA014095-12,NIAAA:264178\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,PSYCHIATRY,06,183710748,US,MEDICAL UNIVERSITY OF SOUTH CAROLINA,SC,29425," Alcoholism is a major health concern as well as a significant social and economic burden on society in the U.S., and stress is known to contribute to the problem. This research project aims to enhance our understanding about mechanisms by which stress associated with alcohol dependence promotes excessive drinking. The goal is to facilitate development of new and more effective treatment strategies for alcohol abuse and alcoholism.            ",1955485;,"BECKER, HOWARD C.;","GRANDISON, LINDSEY ",03/01/2003,01/31/2017,Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol relapse;Alcohol withdrawal syndrome;Alcoholism;allostasis;Behavior;Behavior Control;Behavioral;Brain;Brain region;Chronic;Chronic Alcoholic Intoxication;Complement;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;CRF receptor type 1;Dependence;Development;drinking;drinking behavior;Economic Burden;effective therapy;Ethanol;Ethanol dependence;experience;Exposure to;Funding;Goals;Health;Heavy Drinking;Homeostasis;Hypothalamic structure;Intoxication;Knockout Mice;Laboratories;Literature;Maintenance;Mediating;Messenger RNA;Modeling;Molecular;motivational processes;mouse model;Mus;neurochemistry;Neuropeptides;Neurosecretory Systems;Organism;Pathway interactions;Physiological;Pituitary Gland;Play;Process;receptor;relating to nervous system;Research;Research Project Grants;response;Rewards;Role;Self Administration;social;Societies;Stress;Stressful Event;stressor;Structure;Swimming;System;Taxes;Testing;tool;treatment strategy;Work,Ethanol Dependence and Stress Effects on Ethanol Drinking: Role of CRF,14095,ZAA1,Special Emphasis Panel,,,12,264178,
8607103,U01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,U01AA020928,SCHOOLS OF MEDICINE,RFA-AA-11-006,5U01AA020928-03,NIAAA:236250\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PORTLAND,UNITED STATES,GENETICS,03,096997515,US,OREGON HEALTH &SCIENCE UNIVERSITY,OR,972393098," This study will investigate the effect of chronic alcohol use on DNA and gene expression. These studies will determine whether DNA modifications are detected in the blood and brain, and if the changes in the two tissues are similar. These studies represent a novel approach to understanding the epigenetic consequences of alcohol use, and could indicate new directions for the treatment of alcoholism.         ",1951896;,"FERGUSON, BETSY M;","REILLY, MATTHEW ",02/15/2012,01/13/2017,addiction;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol risk;alcohol use disorder;Alcoholism;alcoholism therapy;Alcohols;Alleles;allostasis;Animal Model;Animals;base;biological adaptation to stress;bisulfite;Blood;Brain;brain tissue;Candidate Disease Gene;Chronic;chronic alcohol ingestion;cohort;Corticotropin;Dexamethasone;DNA;DNA Methylation;DNA Modification Process;Dopamine;Endocrine;Environmental Risk Factor;Epigenetic Process;Ethanol;Exons;Functional disorder;Future;Gene Expression;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genome;Genomics;Genotype;Grant;Haplotypes;Heavy Drinking;Human;Hydrocortisone;Hypermethylation;hypothalamic-pituitary-adrenal axis;Immunoprecipitation;Individual;Life Stress;Link;Longitudinal Studies;Macaca mulatta;Measures;Methods;Methylation;Modeling;Modification;Monitor;Monkeys;monoamine;Neurosecretory Systems;Neurotransmitters;next generation sequencing;nonhuman primate;novel;novel strategies;Opioid;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Population;Prefrontal Cortex;Primates;problem drinker;Recording of previous events;Regulation;Reporting;Research;Research Design;response;Risk;Self Administration;Serotonin;Signal Pathway;Stressful Event;Technology;Testing;Tissue Sample;Tissues;Translating;Variant;Variation (Genetics),Genetic and Epigenetic Analysis of Alcohol Self-Administration in Monkeys,20928,ZAA1,Special Emphasis Panel,,,3,236250,
8607104,U01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,U01AA020929,SCHOOLS OF MEDICINE,RFA-AA-11-006,5U01AA020929-03,NIAAA:357288\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,PSYCHIATRY,06,183710748,US,MEDICAL UNIVERSITY OF SOUTH CAROLINA,SC,29425," Excessive alcohol consumption and alcoholism are major public health concerns. This Research Core serves a central function in the INAstress Consortium by providing valuable information and resources regarding stress-ethanol interactions that will not only inform and guide other research projects in the Consortium, but also provide the general field with novel and unique information that will advance our understanding about factors and mechanisms that promote excessive drinking. This is critical for development of new and more effective treatments for alcohol abuse and alcoholism.         ",8764141;,"LOPEZ, MARCELO F.;","BECHTHOLT-GOMPF, ANITA ",02/10/2012,01/31/2017,Acute;Address;Adrenal Glands;Alcohol abuse;Alcohol consumption;alcohol exposure;Alcohol withdrawal syndrome;Alcoholism;allostasis;Animal Model;Animals;Automobile Driving;Behavioral;Brain;C57BL/6 Mouse;Chronic;Chronic stress;Collection;Data;data integration;Dependence;Development;drinking;drinking behavior;effective therapy;Endocrine;Ensure;Ethanol;Ethanol dependence;Evaluation;experience;Exposure to;Fostering;Gene Deletion;Gene Targeting;Genetic;Genomics;Genotype;Goals;Heavy Drinking;Homeostasis;Knockout Mice;Laboratories;Literature;Mediating;Modeling;Molecular;mouse model;Mus;neuroadaptation;neurochemistry;neurophysiology;novel;Organ;Organism;Outcome Study;Physiological;Plasma;Play;preference;prevent;Procedures;public health medicine (field);Regulation;relating to nervous system;Reliability of Results;Research;Research Personnel;Research Project Grants;Resources;Rewards;Role;Standardization;Stress;stressor;System;Taxes;time use;Tissue Sample,Mouse Chronic Intermittent Ethanol (CIE) Core,20929,ZAA1,Special Emphasis Panel,,,3,357288,
8607105,U01,AA,5,N,02/03/2014,02/01/2014,01/31/2015,273,U01AA020930,SCHOOLS OF MEDICINE,RFA-AA-11-006,5U01AA020930-03,NIAAA:165312\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,NEUROSCIENCES,06,183710748,US,MEDICAL UNIVERSITY OF SOUTH CAROLINA,SC,29425,"The results from these studies will provide insight into changes in key brain regions involved in alcohol abuse and dependence. In addition, these studies may identify a novel therapeutic target for the treatment of alcoholism.",8549555;,"MULHOLLAND, PATRICK J;","CUI, CHANGHAI ",02/10/2012,01/31/2017,Action Potentials;Adrenal Glands;Affect;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol seeking behavior;alcoholism therapy;Alcohols;Apamin;Biochemical;Brain;Brain region;Calcium;Chronic;Chronic stress;Cognitive;Complement;Consumption;Data;density;Dependence;Down-Regulation;drinking;drinking behavior;drug seeking behavior;Ethanol;Ethanol dependence;Exposure to;Feedback;Functional disorder;Glutamates;Heavy Drinking;hippocampal pyramidal neuron;Hippocampus (Brain);Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Image;innovation;insight;Laboratories;Lead;Link;Medial;Mediating;Mediator of activation protein;Microinjections;Molecular;Mus;N-Methyl-D-Aspartate Receptors;neuroadaptation;neurochemistry;Neurons;new therapeutic target;novel;Nucleus Accumbens;Pacemakers;Pathway interactions;Pattern;Pharmaceutical Preparations;Pituitary Gland;postsynaptic;Prefrontal Cortex;Protocols documentation;Relapse;response;Role;Signal Transduction;SK potassium channel;Stress;Structure;Synapses;synaptic function;Synaptic plasticity;Techniques;Testing;Vertebral column;Water consumption;Withdrawal,Stress and Ethanol Dependence: SK Channels and Glutamate,20930,ZAA1,Special Emphasis Panel,,,3,165312,
8588996,U10,HL,5,N,02/06/2014,01/01/2014,12/31/2014,837,U10HL110337,,RFA-HL-12-001,5U10HL110337-03,NHLBI:442741\,Other Research Related,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,07,073130411,US,MASSACHUSETTS GENERAL HOSPITAL,MA,02199,,1890133;1916310 (contact);,"GIVERTZ, MICHAEL M;SEMIGRAN, MARC J (contact);","SHAH, MONICA R",01/01/2012,12/31/2018,"Address;Admission activity;Ancillary Study;arm;Basic Science;Cardiac;Cardiopulmonary;Caring;Cessation of life;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;comparative effectiveness;Consensus;cytokine;Data;Databases;design;Development;Dilated Cardiomyopathy;Educational Curriculum;Enrollment;ethnic minority population;Exercise;experience;Functional disorder;Funding;Future;General Hospitals;Genes;Hand;Health;Heart failure;Hemoglobin;hepcidin;Hospitalization;Hospitals;improved;indexing;Individual;Instruction;Intravenous;Investigation;Iron;iron deficiency;Iron-Regulatory Proteins;Kidney;Laboratories;Leadership;Left Ventricular Ejection Fraction;Life;Link;Massachusetts;Measures;Medical center;member;Mentors;metabolomics;Mission;Mutation;National Heart, Lung, and Blood Institute;next generation;novel;Oral;Outcome;Oxygen;Oxygen Consumption;Pathologic;Patient Recruitments;Patients;Pattern;Performance;Physiological;Placebos;Plasma;Population;Population Heterogeneity;prevent;Principal Investigator;programs;Protocols documentation;Quality of life;randomized trial;rapid growth;Research;Research Design;Research Personnel;response;Role;Science;Site;Skeletal muscle structure;skills;System;Techniques;Testing;Therapeutic;Time;Training;Training Support;Translating;treatment strategy;uptake;Ventricular Function;Woman;Work",Harvard Regional Clinical Center of the NHLBI Heart Failure Network,110337,ZHL1,Special Emphasis Panel,,,3,442741,
8601755,U10,NS,5,N,02/06/2014,12/01/2013,11/30/2014,853,U10NS044446,SCHOOLS OF MEDICINE,RFA-NS-13-002,5U10NS044446-12,NINDS:49975\,Other Research Related,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,NEUROLOGY,07,188435911,US,UNIVERSITY OF MARYLAND BALTIMORE,MD,212011508,"PUBLIC HEALTH RELEVANCE: For people with Parkinson's disease, there is no greater priority than to find new approaches that will delay disease progression. The NET-PD project has been a special and unique source of encouragement to people with PD since it is dedicated to the discovery of strategies for disease modification and employs novel approaches to identify promising agents and to investigate their potential.        Disclaimer:  Please note that the following critiques were prepared by the reviewers prior to the Study Section meeting and are provided in an essentially unedited form.  While there is opportunity for the reviewers to update or revise their written evaluation, based upon the group's discussion, there is no guarantee that individual critiques have been updated subsequent to the discussion at the meeting.  Therefore, the critiques may not fully reflect the final opinions of th individual reviewers at the close of group discussion or the final majority opinion of the group. Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting.                ",7003783;,"SHULMAN, LISA M.;","MOY, CLAUDIA S",09/30/2002,11/30/2014,Activities of Daily Living;base;Caring;Clinical;Clinical Trials;cognitive function;Commit;Creatine;Critiques;design;Digit structure;disability;Disease;Disease Progression;Dose;Double-Blind Method;England;Enrollment;Evaluation;follow-up;Futility;Health Services;Individual;innovation;Levodopa;Maryland;Measures;meetings;Mental Depression;Methods;Modality;Modification;National Institute of Neurological Disorders and Stroke;Neurodegenerative Disorders;neuroprotection;novel strategies;Nursing Homes;Occupations;Outcome Measure;Parkinson Disease;Participant;Patients;Phase III Clinical Trials;Placebos;primary outcome;public health relevance;Quality of life;Randomized;Research;Safety;Sampling;Site;Source;Study Section;success;Testing;Therapeutic Equivalency;Toxic effect;treatment effect;Universities;Update;Visit;Work;Writing,A Simple Neuroprotection Trial in Parkinson's Disease,44446,ZNS1,Special Emphasis Panel,,,12,49975,
8554393,U18,NS,5,N,02/05/2014,01/01/2014,12/31/2014,853,U18NS082132,SCHOOLS OF MEDICINE,RFA-NS-12-010,5U18NS082132-02,NINDS:263700\,Other Research Related,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BIRMINGHAM,UNITED STATES,NEUROLOGY,07,063690705,US,UNIVERSITY OF ALABAMA AT BIRMINGHAM,AL,35294,"PUBLIC HEALTH RELEVANCE: Over one-million Americans may be affected with Parkinson's disease, a devastating neurodegenerative disorder for which there is no cure. This proposal will seek out new markers to aid in disease diagnosis and tracking of disease progression, which may directly benefit patients affected with Parkinson's disease and help power future clinical trials for the discovery of new therapeutics.                ",6986098;,"WEST, ANDREW B;","BABCOCK, DEBRA J.",09/30/2012,12/31/2015,Address;Affect;Age;American;Animal Model;Biochemical Pathway;Biological Assay;Biological Markers;Bladder Control;Cancer Patient;case control;cell motility;Clinic;Clinical;Clinical Trials;cohort;Data;Disease;disease diagnosis;Disease Progression;Disease susceptibility;Future;Gender;Genetic;Golgi Apparatus;Heterogeneity;high risk;Human;Individual;inhibitor/antagonist;innovation;insight;interest;kinase inhibitor;leucine-rich repeat kinase 2;Link;link protein;LRRK2 gene;Mass Spectrum Analysis;Measurement;Measures;Meta-Analysis;Monitor;multicatalytic endopeptidase complex;Nerve Degeneration;nervous system disorder;Neurodegenerative Disorders;novel;novel marker;novel therapeutics;Paper;Parkinson Disease;Parkinsonian Disorders;Pathway Analysis;Pathway interactions;Patients;Phosphorylation;Population;Power Sources;Predisposition;protein degradation;Proteins;Proteome;Proteomics;Protocols documentation;public health relevance;Reproducibility;Running;Sample Size;Sampling;screening;Series;Specimen;Staging;Technology;Therapeutic;Time;Tissues;trafficking;urinary;Urine;Western Blotting,LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease,82132,ZNS1,Special Emphasis Panel,,,2,263700,
8610189,U24,NS,5,N,02/05/2014,02/01/2014,01/31/2015,853,U24NS063930,SCHOOLS OF MEDICINE,,5U24NS063930-05,NINDS:1021053\,Other Research Related,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,NEUROLOGY,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"Public Health Relevance:  This project will make expensive, difficult-to-acquire, high quality data collected from electrodes implanted in patients during clinical care available to researchers world-wide who work on epilepsy. It will allow them to develop new sensors, devices and treatments for epilepsy. It will also help them understand how seizures and epilepsy begin, so that they can develop new treatments to prevent or cure them.          ",7838057;,"LITT, BRIAN;","STEWART, RANDALL R",02/15/2010,01/31/2015,Algorithms;American;animal data;Animal Model;Animals;Area;Basic Science;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Data;Data Collection;data format;data management;Data Quality;Data Set;Databases;Detection;detector;Development;Devices;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;Equilibrium;European;Evaluation;Event;Fees and Charges;Funding;Generalized Epilepsy;Generations;Goals;Grant;High Frequency Oscillation;Human;human data;Implant;Implanted Electrodes;improved;Industry;International;Laboratories;Length;Link;Lobe;meetings;Microelectrodes;Morphologic artifacts;neocortical;open source;Operative Surgical Procedures;Patients;Pennsylvania;prevent;Principal Investigator;Process;programs;prototype;public health relevance;Qualifying;Refractory;Research;Research Personnel;Sampling;Scientist;Seizures;sensor;Shipping;Ships;Societies;Software Tools;Thalamic structure;Therapeutic;tool;United States National Institutes of Health;Universities;Waxes;wiki;Work,The International epilepsy electrophysiology database,63930,ZNS1,Special Emphasis Panel,,,5,1021053,
8583329,U54,HG,5,N,02/05/2014,11/01/2013,10/31/2014,172,U54HG003079,SCHOOLS OF MEDICINE,RFA-HG-10-015,5U54HG003079-11,NHGRI:6397342\,Research Centers,2014,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,SAINT LOUIS,UNITED STATES,GENETICS,01,068552207,US,WASHINGTON UNIVERSITY,MO,631304862,"The potential for DNA sequencing to transform medical practice and change our understanding of disease has never been higher. Our group combines years of experience in DNA sequencing with key clinical researchers to address important questions in patient care and outcome. These early efforts will translate to a revolution in medicine, centered around DNA-based diagnostics including whole genome sequencing.",2078516;,"WILSON, RICHARD K.;","FELSENFELD, ADAM ",11/10/2003,10/31/2015,Address;Adoption;Area;base;Biological;Biomedical Research;cancer genomics;Chromosomes;Clinical;Clinical Medicine;cohort;Collaborations;Complex;cost effective;Coupled;Data;Data Analyses;Detection;Development;Diagnosis;Diagnostic;Disease;DNA;DNA Sequence;DNA Sequence Analysis;exome;experience;Explosion;flexibility;Funding;Future;Generations;Genome;genome analysis;genome sequencing;genome-wide;Genomics;global health;Goals;Grant;Health;Human;Human Genome;Human Microbiome;improved;innovation;instrumentation;Intake;interdisciplinary approach;interest;International;Large-Scale Sequencing;Leadership;Malignant Neoplasms;Medical;medical schools;Medicine;Metagenomics;Methylation;microbial;microbial disease;Mission;Modeling;National Human Genome Research Institute;new technology;next generation sequencing;Outcome;outreach;pathogen;Patient Care;Positioning Attribute;Procedures;Process;Production;protocol development;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Sampling;Scientist;Sequence Analysis;Staging;success;System;Technology;technology development;transcriptome sequencing;Translating;United States National Institutes of Health;Variant;Vision;Work,A Platform for Large-Scale Genomic Discovery,3079,ZHG1,Special Emphasis Panel,,,11,6397342,
8544883,U79,SM,5,N,07/12/2013,09/30/2013,09/29/2014,,U79SM061192,,RFA-SM-12-007,5U79SM061192-02,,Unknown,2013,Center for Mental Health Services,,ANN ARBOR,UNITED STATES,,12,073133571,US,UNIVERSITY OF MICHIGAN,MI,481091274,,11553710;,"KAPLOW, JULIE;","CURL, KENNETH ",09/30/2012,09/29/2016,,The Trauma and Grief Clinic for Youth: Promoting Community-Wide Best Practices,61192,ZOA1,Special Emphasis Panel,,,2,,
8701341,UM1,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,UM1HL088957,SCHOOLS OF MEDICINE,RFA-HL-13-017,5UM1HL088957-07,NHLBI:360000\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,SURGERY,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"PUBLIC HEALTH RELEVANCE: The cardiac surgical trials and registries developed in the NHLBI CTSNetwork are essential for the development of novel biologies and devices, as well as evidence based cardiac surgical decision making in order to improve the health and welfare of patients with cardiovascular disease undergoing cardiac surgery.",2073324;,"ACKER, MICHAEL ANDREW;","MILLER, MARISSA A.",09/30/2007,01/31/2018,"Adult;Awareness;Biology;Cardiac;Cardiac Surgery procedures;Cardiology;Cardiovascular Diseases;Cardiovascular system;Center for Translational Science Activities;Chairperson;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Commit;Community Outreach;Decision Making;Development;Devices;Enrollment;Ensure;Event;evidence base;experience;Faculty;Health;Hospitals;improved;Infection;innovation;Learning;medical schools;Medicine;meetings;member;Mission;multidisciplinary;National Heart, Lung, and Blood Institute;Nature;Neurologist;novel;Nurses;Operative Surgical Procedures;Participant;Patients;Pennsylvania;Philadelphia;randomized trial;Recruitment Activity;Registries;Research;Research Infrastructure;Resolution;Resources;Site;Social Welfare;success;Techniques;Universities;Update;Ventricular",Cardiac Surgical Techniques to Treat Ventricular and Aortic Remodeling,88957,ZHL1,Special Emphasis Panel,,,7,360000,
8701392,UM1,HL,5,N,02/06/2014,02/01/2014,01/31/2015,837,UM1HL117924,SCHOOLS OF MEDICINE,RFA-HL-13-017,5UM1HL117924-02,NHLBI:354303\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOS ANGELES,UNITED STATES,SURGERY,37,072933393,US,UNIVERSITY OF SOUTHERN CALIFORNIA,CA,900899235,RELEVANCE: Cardiovascular disease constitutes a large morbidity and mortality burden in the United States and consumes a large portion of the health care bill. We propose to join the Cardiothoracic Surgical Trials Network as a Core Clinical Center to conduct multiple collaborative trials to improve the treatment of cardiovascular conditions in adults.,11323171;,"BOWDISH, MICHAEL EUGENE;","MILLER, MARISSA A.",07/15/2013,01/31/2018,Address;Adult;Ally;Anesthesiology;Aortic Aneurysm;Bioinformatics;Biometry;California;Cardiac Surgery procedures;Cardiology;Cardiovascular Diseases;Cardiovascular system;Caring;Cessation of life;Chest;Clinical;Clinical Research;Clinical Sciences;Clinical Trials Design;collaborative trial;Commit;Coronary Artery Bypass;cost;Critical Care;data management;Death Rate;Disease;Dissection;Economics;Educational aspects;Enrollment;Ethnicity aspects;evidence base;Expenditure;experience;Goals;Health Policy;Healthcare;Hispanics;improved;innovation;Institutes;Intervention;Location;Los Angeles;Medical;medical schools;medical specialties;Morbidity - disease rate;Mortality Vital Statistics;Nafion;Nature;Neurology;Operative Surgical Procedures;Outcome;Patient Care;patient population;Patients;Pharmacy Schools;Population Heterogeneity;Positioning Attribute;Price;Principal Investigator;programs;protocol development;Public Policy;quality assurance;Race;Randomized;Randomized Clinical Trials;Recording of previous events;Recruitment Activity;Registries;repaired;Research;Research Personnel;Research Proposals;Resources;Schools;Site;Socioeconomic Status;socioeconomics;success;Surgeon;Surgical Management;Therapeutic;tool;Translational Research;United States;Universities;ventricular assist device,USC Cardiothoracic Surgical Trials Network Core Clinical Center,117924,ZHL1,Special Emphasis Panel,,,2,354303,
8703177,UM1,HL,5,N,02/04/2014,02/01/2014,01/31/2015,837,UM1HL118007,,RFA-HL-13-017,5UM1HL118007-02,NHLBI:227850\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,,CANADA,,,208704593,CA,LAVAL UNIVERSITY,PQ,,RELEVANCE: The CTSN network elaborates trials on important questions in the field of Cardiac Surgery. Findings will allow a better treatment selection in patients suffering from cardiac diseases and ultimately enhanced patient quality of life and survival.,11434094;,"VOISINE, PIERRE;","MILLER, MARISSA A.",07/17/2013,01/31/2018,base;Budgets;Cardiac Surgery procedures;Cardiovascular Diseases;Clinical;Clinical Research;Clinical Treatment;Enrollment;experience;Funding Opportunities;Grant;Heart Diseases;Immune;innovation;Nature;Operative Surgical Procedures;Patient Recruitments;Patients;Quality of life;Randomized;Randomized Controlled Trials;Recruitment Activity;Resources;Selection for Treatments;success;treatment strategy,IUCPQ application for Core Clinical Center for CTSN Network,118007,ZHL1,Special Emphasis Panel,,,2,227850,
8734786,DP2,OD,6,N,02/05/2014,07/01/2013,06/30/2015,855,DP2OD007423,SCHOOLS OF MEDICINE,RFA-RM-09-011,6DP2OD007423-02,NIAID:1263754\,Research Projects,2010,"OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH",,NEWARK,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,10,078795851,US,RBHS-NEW JERSEY MEDICAL SCHOOL,NJ,071032757,,8365249;,"ZHAO, XILIN;","BASAVAPPA, RAVI ",09/30/2010,06/30/2015,,Anaerobic shock as a novel treatment for tuberculosis,7423,ZGM1,Special Emphasis Panel,,,2,1263754,
8763975,DP2,OD,7,N,02/05/2014,07/01/2013,06/30/2014,310,DP2OD006478,SCHOOLS OF MEDICINE,RFA-RM-09-003,7DP2OD006478-02,OD:535096\,Research Projects,2009,"OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH",,PISCATAWAY,UNITED STATES,BIOCHEMISTRY,06,078795875,US,RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL,NJ,088548021,,8576183;,"NANDA, VIKAS;","BASAVAPPA, RAVI ",09/30/2009,06/30/2014,,Computational Design of a Synthetic Extracellular Matrix,6478,ZGM1,Special Emphasis Panel,,,2,535096,
8757830,F32,GM,7,N,02/07/2014,07/01/2013,02/14/2014,859,F32GM105104,,PA-11-113,7F32GM105104-02,NIGMS:30682\,"Training, Individual",2013,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,,01,005421136,US,UNIVERSITY OF CHICAGO,IL,60637,"PUBLIC HEALTH RELEVANCE: Investigating the mechanisms of protein folding is the initial step towards determining the molecular origins of neurodegenerative disorders such as Parkinson, Huntington and Alzheimer's diseases as well as understanding protein-drug interactions from a dynamical standpoint. The goal of this project is to develop a general technique-based on a combination of ultrafast infrared spectroscopy, frequency maps, and cutting-edge molecular dynamics simulations-to extract biomolecular structure and dynamics, including protein denaturation, folding, and aggregation pathways by measuring the correlated motions between residues as the proteins undergo conformational changes.            ",10714164;,"BAIZ, CARLOS RAUL;","FLICKER, PAULA F.",02/15/2013,02/14/2015,Address;aggregation pathway;Alzheimer's Disease;Amides;base;Biological Models;Biological Process;Biophysics;Cereals;cluster computing;Data;Development;DNA Sequence Rearrangement;Drug Interactions;Environment;Event;flexibility;Free Energy;Frequencies (time pattern);Genetic;globular protein;Goals;Heterogeneity;Huntington Disease;Hydrogen Bonding;infrared spectroscopy;Kinetics;Lasers;Lead;Link;Maps;Measures;Methods;millisecond;Modeling;Molecular;molecular dynamics;Molecular Structure;Motion;nanosecond;network models;Neurodegenerative Disorders;Parkinson Disease;Pathway interactions;Process;protein aggregation;Protein Denaturation;protein folding;protein structure;Proteins;public health relevance;research study;Resolution;response;Sampling;Side;Simulate;simulation;Solutions;Solvents;Spectrum Analysis;Speed (motion);Stretching;Structure;Techniques;temperature jump;Theoretical Studies;Thermodynamics;Time;tool;two-dimensional;Vertebral column;vibration,Developing a spectroscopic toolkit for probing protein structure and folding,105104,ZRG1,Special Emphasis Panel,,,2,30682,
8787557,K01,AR,7,N,02/06/2014,02/06/2014,03/31/2014,846,K01AR064351,SCHOOLS OF MEDICINE,PA-11-190,7K01AR064351-02,NIAMS:83181\,Other Research Related,2013,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,WORCESTER,UNITED STATES,ORTHOPEDICS,02,603847393,US,UNIV OF MASSACHUSETTS MED SCH WORCESTER,MA,016550002,"PUBLIC HEALTH RELEVANCE: The burden of arthritis involves not only the morbidity from arthritis, but also its associated sequelae and premature mortality. Our ability to prevent the debilitating sequelae and costly outcomes of rheumatic conditions depends on relevant knowledge of the risks of these events, and particularly on an accurate understanding of modifiable risk factors for the development of these sequelae. Our aims would help move the field forward in several major ways: 1) evidence obtained from this project regarding the true impact of these key factors will directly inform practice recommendations to prevent and manage these major outcomes;2) the approach and results from the proposed research could help shift the paradigms in the field of rheumatic disease outcomes research;3) the application of methods from this research could also be relevant to research on many non-rheumatic diseases including studies on risk factors for recurrent cardiovascular outcomes among people with heart attacks.            ",11327168;,"NGUYEN, UYEN-SA DUC TRAN;","SERRATE-SZTEIN, SUSANA ",04/01/2013,03/31/2018,,Collider Bias and the Risk Factor Paradoxes in Rheumatic Disease Research,64351,AMS,Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee,,,2,83181,
8791378,K08,HS,7,N,02/06/2014,11/01/2013,07/31/2014,226,K08HS018341,SCHOOLS OF MEDICINE,PAR-09-085,7K08HS018341-06,,Other Research Related,2013,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,AURORA,UNITED STATES,DERMATOLOGY,06,041096314,US,UNIVERSITY OF COLORADO DENVER,CO,800452571,"Project Narrative The proposed research to study the effectiveness of a patient-centered online model for delivering follow-up specialist care is relevant to public health in several important aspects. This online model will empower patients to be active participants in their health care by enabling them to monitor, document, and communicate their clinical progress with their specialists directly. Patients living in remote areas will have improved access to specialists for follow-up care and save valuable time and costs associated with an office visit. Furthermore, the incorporation of this type of online model into an existing face-to-face practice may help shorten wait times for new patients and patients requesting urgent visits. This research study will yield important findings on clinical outcomes, quality of life measures, and patient satisfaction of this online model compared with the gold standard of traditional, face-to-face visits. If the online model for delivering follow- up specialist care is shown to be effective, this patient-centered model has the potential to increase patient access to specialists and improve quality of care for many Americans.",9747658;,"ARMSTRONG, APRIL W.;","ANDERSON, KAY ",09/30/2009,07/31/2014,,Patient-Centered Online Care Model for Follow-Up Management of Atopic Dermatitis,18341,HCRT,HSR Health Care Research Training SS,,,6,,
8608576,P01,HL,7,N,02/07/2014,02/01/2014,01/31/2015,837,P01HL081588,,PAR-10-285,7P01HL081588-08,NHLBI:1830260\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,,04,057163172,US,"BLOODCENTER OF WISCONSIN, INC.",WI,53233,"RELEVANCE: This PPG is tightly focused on von Willebrand Disease that is a very common clinical bleeding disorder. In some studies its prevalence may be as high as 1-2% of the general population. Based on the NHLBI Guidelines (2006), the importance of under-diagnosis and over-diagnosis are major Public Health issues. This PPG and its three tightly interactive projects is focused on addressing these issues at a clinical, diagnostic and a molecular level. (End of Abstract)",1893584;,"MONTGOMERY, ROBERT R;","LINK, REBECCA P.",08/01/2005,01/31/2017,"abstracting;Address;African American;base;Biology;Canada;Clinical;clinical phenotype;Code;cohort;Cohort Studies;Collaborations;Country;Diagnosis;diagnosis evaluation;Diagnostic;Disease;disease diagnosis;Dominant-Negative Mutation;European Union;Foundations;Functional disorder;Funding;Future;General Population;Genetic Polymorphism;genome wide association study;Guidelines;Hemophilia A;Hemorrhage;improved;In Vitro;in vivo;Individual;interest;International;Laboratories;Menorrhagia;Molecular;Molecular Biology;multidisciplinary;Mus;Mutation;Names;National Heart, Lung, and Blood Institute;next generation sequencing;Other Genetics;Participant;Pathologic;Pathway interactions;Patients;Phenotype;Pilot Projects;Plasma;Prevalence;Program Research Project Grants;programs;public health medicine (field);Quality of life;Recording of previous events;Research;Research Personnel;Staging;Symptoms;Testing;Time;treatment center;United Kingdom;United States;United States National Institutes of Health;Variant;von Willebrand Disease;von Willebrand Factor;VWF gene",Zimmerman Program for the Molecular and Clinical Biology of VWD,81588,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,,8,1830260,
8608577,P01,HL,7,N,02/07/2014,02/01/2014,01/31/2015,,P01HL081588,,PAR-10-285,7P01HL081588-08,NHLBI:263168\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,,04,057163172,US,"BLOODCENTER OF WISCONSIN, INC.",WI,53233,"This project addresses critical issues around the fidelity of the diagnosis of von Willebrand Disease in the  United States. The diagnosis of this genetically acquired disorder may not be confirmed by subsequent  retesting. Diagnostic category requires a careful evaluation and correlation of clinical laboratory testing,  clinical phenotyping, and molecular genotyping on a world-wide basis.",1893584;,"MONTGOMERY, ROBERT R;",,,,"Abbreviations;Abnormal Laboratory Test Result;Address;Adult;Affect;African American;Antibiotics;Asian Americans;base;Binding (Molecular Function);Biological Assay;Biology;Blood Platelets;Categories;Clinical;clinical phenotype;clinically relevant;cohort;comparative;Data;Diagnosis;Diagnostic;Disease;Dose;Enrollment;Enzyme-Linked Immunosorbent Assay;Ethnicity aspects;European Union;Evaluation;Family;Female;Funding;Gene-Modified;Genetic Polymorphism;Genotype;Guidelines;Hemophilia A;Hemorrhage;Hispanic Americans;improved;In Vitro;in vivo;indexing;Indiana;Individual;Label;Laboratories;meetings;Menorrhagia;Molecular;Mutation;National Heart, Lung, and Blood Institute;New York;Pathway interactions;Patients;Pattern;Phenotype;Pilot Projects;Population;Population Study;programs;public health medicine (field);Quality of life;Race;Reagent;Recording of previous events;Recruitment Activity;Research;Research Design;Risk;Ristocetin;Scientist;Sensitivity and Specificity;Symptoms;System;Test Result;Testing;Thrombocytopenia;Time;time use;treatment center;United States;United States National Institutes of Health;Variant;von Willebrand Disease;Woman;Women's Health",Molecular Impact of VWF on Clinical VWD,81588,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7292,,8,,263168
8608578,P01,HL,7,N,02/07/2014,02/01/2014,01/31/2015,,P01HL081588,,PAR-10-285,7P01HL081588-08,NHLBI:275711\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,,04,057163172,US,"BLOODCENTER OF WISCONSIN, INC.",WI,53233,"RELEVANCE (See instructions):  This project studies the role of von Willebrand factor (VWF) in von Willebrand disease (VWD). This project will explore the mechanisms causing type 1 VWD, specifically the effect of mutations identified in these patients on VWF production, degradation and clearance. These studies will increase our understanding of mechanisms causing VWD, and will lead to the development of more effective treatment strategies.",1893584;,"MONTGOMERY, ROBERT R;",,,,ADAMTS;Address;Amino Acid Sequence;base;Binding (Molecular Function);Biology;Blood Circulation;Blood groups;Blood Platelets;Blood typing procedure;Blood Vessels;Carbohydrates;Carrier Proteins;Cells;Characteristics;Clinical;Code;Complex;Data Analyses;DDAVP;Defect;Development;Disease;disease phenotype;effective therapy;Elements;extracellular;Factor VIII;Genotype;Goals;Grant;Half-Life;Hemorrhage;Hemostatic function;Human;In Vitro;in vivo;Individual;Inherited;Injury;Instruction;Knowledge;Lead;Mediating;Modeling;Modification;Molecular;Mus;mutant;Mutation;novel;Organ;Pathogenesis;Patients;Phenotype;Plasma;Play;Predisposition;Process;Production;programs;Proteins;Proteolysis;Recombinants;Reporting;residence;Role;Site;System;Testing;Time Factors;Tissues;treatment strategy;Variant;von Willebrand Disease;von Willebrand Factor,Molecular Mechanisms of VWF Alteration in Vitro/Vivo,81588,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7293,,8,,275711
8608580,P01,HL,7,N,02/07/2014,02/01/2014,01/31/2015,,P01HL081588,,PAR-10-285,7P01HL081588-08,NHLBI:330137\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,,04,057163172,US,"BLOODCENTER OF WISCONSIN, INC.",WI,53233,"RELEVANCE (See instructions):  This research project addresses the genetic background of two inherited bleeding disorders, one, type 1 von Willebrand disease, that is the most common bleeding problem encountered in the general population, and the second, type 3 von Willebrand disease, a rare variant form of the condition. Both diseases result in chronic morbidities due to recurrent excessive mucocutaneous bleeding.",1893584;,"MONTGOMERY, ROBERT R;",,,,Address;Affect;Anabolism;autosomal dominant trait;base;Binding (Molecular Function);Binding Proteins;Biology;Blood Platelets;C-Type Lectins;Canada;Cells;Cellular biology;Chronic;Classification;Clinical;cohort;Complex;Copy Number Polymorphism;Data;Defect;Diagnostic;Disease;disease phenotype;Exons;experience;Factor VIII;Family;gastrointestinal;General Population;Genes;Genetic;genetic association;Genetic Determinism;genetic linkage;Genetic Predisposition to Disease;genetic variant;genome wide association study;Hemorrhage;Heterogeneity;Human;Incidence;indexing;Inherited;insight;Instruction;Investigation;Knowledge;Maps;member;Menorrhagia;Meta-Analysis;Mind;Molecular;Morbidity - disease rate;Musculoskeletal;Mutation;novel;Nucleic Acid Regulatory Sequences;Other Genetics;Pathogenesis;Pathology;Patients;Penetrance;Phenotype;Plasma;Play;Population;Prevalence;prevent;Program Research Project Grants;programs;Promotor (Genetics);prophylactic;Proteins;Publishing;receptor;Recurrence;Reporting;reproductive;Research Project Grants;Research Proposals;RNA Splicing;Role;scavenger receptor;Signal Transduction;Site;Symptoms;syntaxin;syntaxin-2;System;Time;trait;Variant;von Willebrand Disease;von Willebrand Factor;von Willebrand factor receptor;Woman,Genetic Determinants of Quantitative Variants of von Willebrand Disease,81588,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7294,,8,,330137
8608581,P01,HL,7,N,02/07/2014,02/01/2014,01/31/2015,,P01HL081588,,PAR-10-285,7P01HL081588-08,NHLBI:550342\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,,04,057163172,US,"BLOODCENTER OF WISCONSIN, INC.",WI,53233,,1893584;,"MONTGOMERY, ROBERT R;",,,,Administrative Coordination;Advisory Committees;Agreement;American Society of Hematology;arm;base;Biology;Blood;Childhood;Clinical;Data;Databases;Diagnostic;Disease;Faculty;Floods;Funding;Gills;Hematology;Hemorrhage;Hemostatic function;Institution;Laboratories;Laboratory Research;Leadership;Location;meetings;member;Molecular;Patients;pediatric department;Phenotype;programs;Quality Control;Research;Research Institute;Research Personnel;Sampling;Schedule;Scientist;Site;Study Subject;symposium;System;Validation;Wisconsin,Administrative and Clinical Acquisition Core,81588,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7295,,8,,550342
8608582,P01,HL,7,N,02/07/2014,02/01/2014,01/31/2015,,P01HL081588,,PAR-10-285,7P01HL081588-08,NHLBI:410902\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,,04,057163172,US,"BLOODCENTER OF WISCONSIN, INC.",WI,53233,RELEVANCE (See instructions):  This Core assures comparable quality of the VWF laboratory phenotyping and assures identical handling of all samples by the Central Lab.,1893584;,"MONTGOMERY, ROBERT R;",,,,Aliquot;Antigens;Base Sequence;Binding (Molecular Function);Biological Assay;Biology;Blood;Blood capillaries;Blood groups;Blood typing procedure;Boston;capillary;Clinical;Coagulants;Code;Collagen;cost;Country;Data;Databases;design;Devices;Diagnostic;DNA Sequence;DNA Sequence Analysis;Doctor of Philosophy;Equipment;Evaluation;Factor VIII;Gel;Hemostatic function;Immunoassay;Individual;Instruction;Label;Laboratories;Latex;Left;medical schools;Molecular;Molecular Analysis;North America;Output;Patients;Phenotype;Physiological;Plasma;Process;programs;Role;Sampling;screening;Site;System;Techniques;Testing;Universities;von Willebrand Factor;VWF gene;Wisconsin,VWF Phenotyping and Molecular Analysis Core,81588,HLBP,"Heart, Lung, and Blood Program Project Review Committee",7296,,8,,410902
8663111,R01,AA,7,N,02/05/2014,07/01/2013,03/31/2014,273,R01AA013438,SCHOOLS OF MEDICINE,PA-12-270,7R01AA013438-11,NIAAA:251498\,Research Projects,2012,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,SAN FRANCISCO,UNITED STATES,NEUROLOGY,12,094878337,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"PUBLIC HEALTH RELEVANCE: Alcoholism is a devastating disease that affects approximately 14 million people per year in the USA alone. Unfortunately, only limited numbers of drugs are currently approved by the FDA to treat adverse phenotypes associated with the disease. Therefore, there is a great need to identify novel targets for medication development. The ion channel NMDAR has attracted great interest as a potential drug target to treat alcoholism and other neurological diseases. Results generated from these studies may enable us to develop agents that modulate the activity of a subset population of the channel in specific areas of the brain, and therefore may lead to the development of novel, selective targets to treat alcohol abuse.",6807030;,"RON, DORIT;","CUI, CHANGHAI ",07/01/2013,03/31/2014,,Phosphorylation and the CNS Actions of Ethanol,13438,ZRG1,Special Emphasis Panel,,,11,251498,
8618864,R01,AR,7,N,02/01/2014,02/01/2014,01/31/2015,846,R01AR048155,,PA-11-260,7R01AR048155-10,NIAMS:321300\,Research Projects,2014,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,PHILADELPHIA,UNITED STATES,,02,073757627,US,CHILDREN'S HOSP OF PHILADELPHIA,PA,191044318,"PUBLIC HEALTH RELEVANCE: Within melanosomes - subcellular organelles of pigment cells of the eye and skin - melanin pigments deposit on fibrils that resemble amyloid, a protein fold normally associated with neurodegeneration (as in Alzheimer and Parkinson Diseases). However, the melanosome fibrils are functional and not pathological. The goal of this proposal is to understand how functional PMEL amyloid forms and whether genetic alterations in its formation generate toxic amyloid. If successful, our results might explain novel forms of pigment loss and lead to novel approaches to detoxify pathological amyloid formation in neurodegenerative diseases and other amyloidoses.            ",1867042;,"MARKS, MICHAEL S;","TSENG, HUNG H",09/01/2001,01/31/2018,Adverse effects;Albinism;Alzheimer's Disease;Amyloid;Amyloid Fibrils;amyloid formation;Amyloidosis;Animal Model;Binding (Molecular Function);Biochemical;Biogenesis;Cell Survival;Cells;Chickens;Cues;Cultured Cells;Cysteine;Data;Defect;Deposition;Dermal;Disease;disulfide bond;Endosomes;Engineering;Equus caballus;Eye;Fiber;Funding;Generations;Genes;Genetic;Goals;Golgi Apparatus;Hair;Health;Human;human PHEMX protein;In Vitro;in vivo;insight;Lead;Lipid Bilayers;Lipids;Liposomes;Melanins;melanocyte;Melanogenesis;Melanosomes;Membrane;Molecular;Mus;Mutagenesis;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;novel;novel strategies;Organelles;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Physiological;Pigment Epithelium of Eye;Pigmentation physiologic function;Pigments;polymerization;polypeptide;Process;Property;protein folding;Proteins;public health relevance;Publishing;Research;research study;Role;Seeds;Shapes;Skin;Skin Pigmentation;Solutions;Sorting - Cell Movement;synuclein;Testing;therapeutic development;Time;Toxic effect;trafficking;Transgenic Mice;Vesicle;Work,Functional Amyloid in Melansome Biogenesis,48155,ACTS,"Arthritis, Connective Tissue and Skin Study Section",,,10,321300,
8728438,R01,CA,7,N,02/06/2014,02/01/2014,01/31/2015,396,R01CA141144,SCHOOLS OF VETERINARY MEDICINE,PA-07-070,7R01CA141144-05,NCI:276286\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,VETERINARY SCIENCES,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104," Project Narrative As the second leading cause of death, cancer presents a major public health problem. Lung cancer is the second most common cancer and the leading cause of cancer deaths. Therefore, there is an urgent need to develop new treatments for lung cancer. We now know that the tumor microenvironment plays a critical role in driving neoplastic transformation and tumor progression. We have obtained evidence that targeting a protease restricted to mesenchymal derived stromal cells, which are prevalent in a wide variety of solid tumors, inhibits tumor growth. The proposed experiments will define the mechanisms that lead to the expression of this protease in tumors and the mechanisms by which it promotes tumor growth. These studies are likely to lead to the clinical development of new anti-tumor therapies that target stromal cells.",1864184;,"PURE', ELLEN PURE';","MOHLA, SURESH ",04/01/2010,01/31/2015,angiogenesis;Automobile Driving;base;Blood Vessels;cancer cell;Cancer Etiology;cancer genetics;Cancer Model;Catalytic Domain;Cause of Death;Cell Proliferation;Cells;Cessation of life;cis acting element;Clinical;Collagen;Common Neoplasm;Data;Development;Dipeptidyl Peptidases;Endopeptidases;Endothelial Cells;Epithelial;Extracellular Matrix;fibroblast-activating factor;Fibroblasts;Fibrosis;Gene Expression Profile;Generations;Goals;Growth;Homeostasis;Human;Immune;In Vitro;in vivo;Inflammatory;Inflammatory Infiltrate;inhibitor/antagonist;Integrins;Kinetics;Knock-in Mouse;Lead;Lung;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;man;Mediating;Mediator of activation protein;Mesenchymal;Modeling;mouse model;Mus;mutant;Mutation;Myofibroblast;Neoplasm Metastasis;neoplastic cell;Neoplastic Cell Transformation;novel;novel therapeutic intervention;Operative Surgical Procedures;Peptide Hydrolases;Pericytes;Play;Population;Process;Promotor (Genetics);protein expression;public health medicine (field);Reporter;research study;Role;Series;Signal Transduction;Smooth Muscle Actin Staining Method;Solid Neoplasm;Specimen;Stromal Cells;Structure;System;Testing;Tissues;Trans-Activators;Transplantation;tumor;tumor growth;tumor initiation;Tumor Markers;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Derived;tumorigenesis;Vascularization;Wound Healing;Xenograft procedure,Fibroblast Activation Protein in the Tumor Microenvironment in Lung Cancer,141144,TME,Tumor Microenvironment Study Section,,,5,276286,
8791355,R01,DC,7,N,02/07/2014,12/01/2013,03/31/2014,173,R01DC002148,SCHOOLS OF MEDICINE,PA-11-260,7R01DC002148-18,NIDCD:548173\,Research Projects,2013,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PHILADELPHIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,002604817,US,DREXEL UNIVERSITY,PA,19104,,1897367;,"EHRLICH, GARTH D.;","WATSON, BRACIE ",12/01/1993,03/31/2018,,Molecular Analysis of Pathogens in Otitis Media by PCR,2148,CRFS,Clinical Research and Field Studies of Infectious Diseases Study Section,,,18,548173,
8754822,R01,DC,7,N,02/07/2014,10/01/2013,06/30/2014,173,R01DC010146,SCHOOLS OF MEDICINE,PA-07-070,7R01DC010146-06,NIDCD:276612\,Research Projects,2013,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,LOS ANGELES,UNITED STATES,SURGERY,33,092530369,US,UNIVERSITY OF CALIFORNIA LOS ANGELES,CA,900952000," Narrative Structural and/or functional damage of the organ of Corti is the major cause of sensori- neural hearing loss afflicting millions of people around the world. The exquisite architecture of the organ of Corti is uniquely adapted to support an enormous range of input sound pressures, and outer hair cells (OHCs) are unique in having their body length directly influencing important aspects of the micromechanics of this organ. For example, minute changes in OHC length can dynamically adjust the operating point of the mechano-sensory apparatus hosted in the cell stereocilia and/or the local resonance of the basilar membrane. Changes in OHC length, known as OHC motility, are thought to be essential for cochlear amplification. Despite their importance, many gaps exist in our knowledge of the structure and function of OHCs. Filling these gaps would be an important step towards a better understanding of cochlear function, malfunctions that involve changes in OHC shape, and protective mechanisms activated in response to overstimulation. We are confident that accomplishing the aims of the present proposal will provide essential information about the structure of OHCs and the role of the cytoskeleton in the regulation of OHC length and motility, as well as critical insights into the basic mechanisms of both normal human hearing and deafness.",2132418;,"KALINEC, FEDERICO;","FREEMAN, NANCY ",07/01/2009,06/30/2014,abstracting;Actins;Address;adducin;Affinity;Architecture;base;Basilar Membrane;Binding (Molecular Function);Cell membrane;cell motility;Cell physiology;Cell Shape;Cells;Cellular Structures;cofilin;Complement;Confocal Microscopy;crosslink;Cytoplasmic Protein;Cytoskeletal Modeling;Cytoskeleton;Data;Deafness;depolymerization;driving force;Electron Microscopy;Family suidae;GLUT-5 protein;Goals;Hearing;hearing impairment;Human;Immunoprecipitation;In Vitro;in vivo;insight;Integral Membrane Protein;Knowledge;Label;Lateral;Length;Light;LIMK1 gene;Link;Mass Spectrum Analysis;Mediating;Methods;Microfilaments;Microscopy;Modification;Molecular;monomer;mouse model;Mus;Nature;Organ;Organ of Corti structure;Outer Hair Cells;Pathway interactions;Phosphorylation;polymerization;pressure;profilin;Proteins;rat Pres protein;Recruitment Activity;Regulation;relating to nervous system;response;Role;Sensory;Signal Transduction;sound;Spectrin;Speed (motion);Stereocilium;Structure;Techniques;Testing;two-dimensional;Video Microscopy;Work,Structural Basis of Outer Hair Cell Function,10146,AUD,Auditory System Study Section,,,6,276612,
8754804,R01,DC,7,N,02/03/2014,10/01/2013,11/30/2013,173,R01DC010397,SCHOOLS OF MEDICINE,PA-07-070,7R01DC010397-05,NIDCD:125034\,Research Projects,2013,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,LOS ANGELES,UNITED STATES,SURGERY,33,092530369,US,UNIVERSITY OF CALIFORNIA LOS ANGELES,CA,900952000," ) ) Narrative Inflammatory responses in the cochlea, triggered by virus, noise, or ototoxic agents, can result in mild to profound hearing loss. The current gold standard clinical strategy to protect the auditory organ against inflammatory damage is the local delivery of glucocorticoids. However, the mechanism by which glucocorticoids confer this protection is still unknown. We are confident that by accomplishing the aims of the present proposal we will be able to provide critical insights about the mechanisms associated with inflammatory and anti-inflammatory responses in the cochlea, as well as identify new molecular targets for prevention and treatment of sudden sensorineural hearing loss.",2132418;,"KALINEC, FEDERICO;","WATSON, BRACIE ",12/01/2009,11/30/2014,Address;Annexin A1;Annexins;Anti-inflammatory;Anti-Inflammatory Agents;Antibodies;Apical;Apoptosis;ATP-Binding Cassette Transporters;Auditory;Cavia;Cell Line;Cells;Clinical;Cochlear duct;Cochlear structure;cofilin;Confocal Microscopy;Cytoplasm;Deafness;Electron Microscopy;extracellular;Freeze Fracturing;Glucocorticoids;Goals;Gold;hearing impairment;Immune response;Immune system;In Vitro;in vitro Model;in vivo Model;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor/antagonist;Injury;insight;Intention;interest;Intracellular Transport;knock-down;Knowledge;Label;Leukocytes;Lipids;lysophosphatidic acid;Lysophospholipids;Mediating;migration;Migration Assay;Molecular Target;Myosin ATPase;Myosin Type II;Noise;non-muscle myosin;Nonmuscle Myosin Type IIA;Organ;Organ of Corti structure;Outer Hair Cells;Pathway interactions;Phase;Play;Predisposition;prevent;Prevention;Proteins;Proteomics;Regulation;Resolution;restoration;Role;Sensorineural Hearing Loss;Site;Small Interfering RNA;Structure;Surface;Techniques;Technology;Testing;Tight Junctions;Tissues;Virus,Regulation of Inflammatory Responses in the Cochlea,10397,AUD,Auditory System Study Section,,,5,125034,
8788745,R01,DE,7,N,02/05/2014,12/23/2013,06/30/2014,121,R01DE018023,SCHOOLS OF DENTISTRY/ORAL HYGN,PA-07-070,7R01DE018023-06,NIDCR:20279\,Research Projects,2012,NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH,,PHILADELPHIA,UNITED STATES,DENTISTRY,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"Project Narrative: This project proposes a novel therapeutic approach to prevent dental caries, the single most prevalent and costly oral infectious diseases in the United States. Our approach uses natural compounds, is highly effective without suppressing the resident oral flora (non-microbiocidal) and may decrease exposure to fluoride.",7534785;,"KOO, HYUN;","LUNSFORD, DWAYNE ",02/19/2008,06/30/2014,,Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutans,18023,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,,6,20279,
8784251,R01,DE,7,N,02/04/2014,11/25/2013,07/31/2014,121,R01DE019226,,PA-07-070,7R01DE019226-07,NIDCR:239341\,Research Projects,2012,NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH,,BOSTON,UNITED STATES,,07,073130411,US,MASSACHUSETTS GENERAL HOSPITAL,MA,02199,"PUBLIC HEALTH RELEVANCE:  This project aims at understanding the molecular mechanism by which Msx1 functions, using the developing tooth, as a model system. To accomplish this purpose, techniques of contemporary molecular biology will be employed to test the proposed hypothesis that the molecular function of Msx1 transcription factor during early tooth development depends on the combinatorial action of a context dependent, tooth-specific transcription factor network and posttranslational modifications.",6061787;,"BEI, MARIANNA;","SCHOLNICK, STEVEN ",08/01/2008,07/31/2014,,Molecular mechanisms of early tooth development,19226,ZRG1,Special Emphasis Panel,,,7,239341,
8796384,R01,ES,7,N,02/07/2014,10/01/2013,02/28/2014,113,R01ES011740,SCHOOLS OF MEDICINE,PA-07-070,7R01ES011740-11,NIEHS:74203\,Research Projects,2012,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,DUKE UNIVERSITY,NC,27705,,1891484;,"WEI, QINGYI;","MCALLISTER, KIMBERLY A.",03/01/2008,02/28/2014,,Molecular Epidemiology of DNA Repair in Head and Neck Cancer,11740,EPIC,Epidemiology of Cancer Study Section,,,11,74203,
8790838,R01,GM,7,N,02/07/2014,12/10/2013,11/30/2014,859,R01GM060293,SCHOOLS OF MEDICINE,PA-10-067,7R01GM060293-15,NIGMS:301244\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,BIOCHEMISTRY,02,042250712,US,UNIVERSITY OF PENNSYLVANIA,PA,19104,"PUBLIC HEALTH RELEVANCE:  Protein Acetyltransferase (PAT) enzymes play key roles in regulating many biological processes and aberrant PAT function has been correlated with several human diseases, including leukemic translocations, solid tumors and metabolic disorders. The overall goal of this project is to elucidate the molecular basis for how PAT enzymes recognize and acetylate their cognate protein substrates and how this process is modulated by protein cofactors and posttranslational modification. The yeast Rtt109 histone acetyltransferase, the human N- amino acetyltransferase complex NATA and the alpha -tubulin acetyltransferase alpha-TAT/MEC-17 will be used as model systems. These studies will provide information to aid in the design small molecule drugs to treat PAT- associated diseases.",1866999;,"MARMORSTEIN, RONEN;","PREUSCH, PETER C.",01/01/2000,11/30/2016,Acetylation;Acetyltransferase;Adopted;alpha Tubulin;base;Binding (Molecular Function);Biochemical;Biological;Biological Models;Biological Process;Biology;Catalysis;Catalytic Domain;Cell Cycle Progression;Chemistry;Coenzyme A;cofactor;Complex;design;Development;Disease;Dosage Compensation (Genetics);Enzymes;EP300 gene;falls;Family;Funding;Genetic Transcription;Genome Stability;Goals;Health;histone acetyltransferase;Histone H3;Histones;Hormones;Human;human disease;human NAT2 protein;Hybrids;inhibitor/antagonist;Laboratories;Mediating;meetings;Metabolic Diseases;Metabolism;Methionine;Microtubules;Modification;Molecular;Molecular Chaperones;N-terminal;Neurons;Nuclear;Nucleosomes;PCAF gene;Peptides;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Play;Post-Translational Protein Processing;Process;Property;Protein Acetylation;protein degradation;protein folding;protein function;Protein Kinase;protein structure function;Proteins;Reporting;Ribosomes;RNA Processing;Roentgen Rays;Side;Signal Transduction;small molecule;Solid Neoplasm;Structure;Substrate Specificity;Therapeutic;therapeutic target;trafficking;Translating;Tubulin;Yeasts,Structure and Function of Protein Acetyltransferases,60293,MSFC,Macromolecular Structure and Function C Study Section,,,15,301244,
8788470,R01,GM,7,N,02/01/2014,09/21/2013,03/31/2014,859,R01GM085309,,PA-07-070,7R01GM085309-05,NIGMS:90743\,Research Projects,2013,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLLEGE STATION,UNITED STATES,,17,835607441,US,TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR,TX,77845,"Narrative Ras is the most commonly mutated oncogene in cancer, and an important Ras effector, RalGEF, functions to activate the Ral small GTPase to promote oncogenesis and metastasis. However, little is known about how RalGEF-Ral signaling promotes tumorigenesis, or even what functions are performed by RalGEF-Ral in an animal. Our studies will address the in vivo function of RalGEF-Ral and its interactions with Ras in one of the best known cell fate induction systems. These studies will provide insights into the previously uncharacterized developmental and molecular mechanisms of RalGEF-Ral signaling, a potential pharmaceutical target.",9241027;,"REINER, DAVID JOHN;","HOODBHOY, TANYA ",04/01/2010,03/31/2015,,The Ral small GTPase in C. elegans development,85309,DEV1,Development - 1 Study Section,,,5,90743,
8775363,R01,GM,7,N,02/03/2014,10/01/2013,06/30/2014,859,R01GM101192,SCHOOLS OF MEDICINE,PA-11-260,7R01GM101192-02,NIGMS:281240\,Research Projects,2013,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHARLOTTESVILLE,UNITED STATES,BIOCHEMISTRY,05,065391526,US,UNIVERSITY OF VIRGINIA,VA,229044195,"DNA fragility generated by alternative secondary structures is a known cause of many human diseases, and can be affected by nucleotide sequences, cellular activities, and environmental exposures. We propose to create a genome-wide DNA secondary structure database for compiling a panel of gene regions with a high potential to form stable secondary structures, and to examine these regions for the effect of both cellular activities and environmental exposures on fragility. This aspires toward future applications of measuring DNA fragility in a personalized approach to diagnostics and treatment.",2214949;,"WANG, YUH-HWA;","KRASNEWICH, DONNA M",07/01/2013,06/30/2017,,Genome-wide DNA Secondary Structure Analysis to Investigate DNA Fragility,101192,GCAT,"Genomics, Computational Biology and Technology Study Section",,,2,281240,
8792335,R01,HL,7,N,02/04/2014,02/01/2014,07/31/2014,837,R01HL093052,SCHOOLS OF MEDICINE,PA-12-270,7R01HL093052-06,NHLBI:51856\,Research Projects,2012,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,VALHALLA,UNITED STATES,PHARMACOLOGY,17,041907486,US,NEW YORK MEDICAL COLLEGE,NY,10595,"PUBLIC HEALTH RELEVANCE: Metabolic syndrome (type II diabetes, obesity and hypertension) patients are at high risk fatal myocardial infarction, in part because they fail to grow collateral vessels in response to transient ischemia (angina pectoris). The first goal of this proposal is to understand the molecular basis of impaired coronary collateral growth in an animal model, which mimics the pathology of the human metabolic syndrome. Since most patients suffering from the metabolic syndrome are on angiotensin type 1 receptor (AT1R) blockers for clinical management of hypertension, heart and/or renal failure, the second goal of this proposal is to understand the interaction between AT1R signaling and the metabolic syndrome phenotype, on a molecular level (signal transduction and oxidative stress) as it relates to coronary collateral growth. The final goal of this proposal is to construct specific therapies aimed at restoration of coronary collateral growth, relevant to the clinical management of metabolic syndrome patients on AT1R blockers.",8338677;,"ROCIC, PETRA;","HASAN, AHMED A.K.",02/01/2014,07/31/2014,,Regulation of Coronary Collateral Growth in the Metabolic Syndrome,93052,MIM,Myocardial Ischemia and Metabolism Study Section,,,6,51856,
8792926,R01,HL,7,N,02/07/2014,02/08/2014,01/31/2015,837,R01HL108962,SCHOOLS OF EDUCATION,PA-10-067,7R01HL108962-04,NHLBI:479199\,Research Projects,2013,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MINNEAPOLIS,UNITED STATES,MISCELLANEOUS,05,555917996,US,UNIVERSITY OF MINNESOTA,MN,554552070,"The proposed research is relevant to public health because complications from heart failure (HF), including symptoms of pulmonary edema, are the number one reason for hospital admissions in the United States. Understanding the genetic influence to this susceptibility is key for therapeutic progress in HF. Thus, the proposed research is relevant to the NIH mission in that it will translate clinical research obtained in a laboratory setting in HF patients to clinical practice.",8084984;,"SNYDER, ERIC M;","HARABIN, ANDREA L",07/01/2011,01/31/2017,,Gene-by-Gene Interactions and Lung Fluid Balance in Patients with Heart Failure,108962,RIBT,Respiratory Integrative Biology and Translational Research Study Section,,,4,479199,
8793824,R01,MH,7,N,02/05/2014,07/01/2013,03/31/2014,242,R01MH096625,SCHOOLS OF MEDICINE,PA-11-260,7R01MH096625-03,NIMH:223570\,Research Projects,2013,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEWARK,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,10,078795851,US,RBHS-NEW JERSEY MEDICAL SCHOOL,NJ,071032757,"As individuals with HIV are living longer due to the success of antiretroviral therapies, the prevalence of cognitive and motor deficits in this infected population is increasing. Astrocytes play a key role in maintaining CNS functions. However, their role in the pathogenesis of NeuroAIDS has not been well characterized, mainly due to the lack of specific molecular tools to examine HIV infection of astrocytes. We and others developed techniques to examine HIV infection of astrocytes in vivo and in vitro and their consequences in brain physiology using gap junction and hemichannels. Our studies already demonstrated that gap junction and hemichannels of Connexin43 (Cx43) are critical to spread damage to neighboring cells despite the few numbers of HIV infected cells and low viral replication. We propose to expand these studies to characterize bystander dysregulation of uninfected astrocytes, neurons and brain endothelial cells. In addition, we will study the molecular mechanism by which gap junction and hemichannels transmit and amplify toxic signals to neighboring cells by examining their activation and regulation. Lastly, we will expand our preliminary data obtained in vivo by using a novel animal model of bystander toxicity mediated by microinjection of few human HIV infected human astrocytes into the brain of animals with astrocytes genetically deleted for Cx43 and to evaluate apoptosis, astrocyte proliferation and BBB disruption in neighboring cells around the microinjected HIV infected astrocytes. The results of these studies may provide information for the development of therapies to treat the neurologic dysfunctions in HIV infected individuals",8319909;,"EUGENIN, ELISEO A;","JOSEPH, JEYMOHAN ",05/07/2012,03/31/2017,,Astrocyte connexin43 containing channels amplify CNS dysfunction in NeuroAIDS,96625,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,,3,223570,
8791989,R01,NS,7,N,02/05/2014,08/17/2013,06/30/2014,853,R01NS052770,SCHOOLS OF ARTS AND SCIENCES,PA-07-070,7R01NS052770-06,NINDS:155942\,Research Projects,2012,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,FORT COLLINS,UNITED STATES,BIOLOGY,04,785979618,US,COLORADO STATE UNIVERSITY,CO,80523,"PUBLIC HEALTH RELEVANCE: When nerve cells and other types of cells are subjected to severe stresses, it can trigger a special pathway that ends up killing the cells. This proposal seeks to better understand how that stress pathway works, so that we might be able to control it in the future. If we could control that pathway, nerve cells might be prevented from dying after some types of injuries or in some degenerative diseases.",1921772;,"KASSENBROCK, CHARLES KENNETH;","MORRIS, JILL A",08/17/2013,06/30/2014,,Regulation of Cellular Signaling Pathways by POSH,52770,NOMD,Neural Oxidative Metabolism and Death Study Section,,,6,155942,
8796332,R21,AI,7,N,02/03/2014,02/03/2013,01/31/2014,855,R21AI101291,,PA-11-149,7R21AI101291-02,NIAID:259199\,Research Projects,2013,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CAMBRIDGE,UNITED STATES,,05,082359691,US,HARVARD UNIVERSITY,MA,02138,"Viral infections have a major impact on public health both domestically and worldwide;however, it is likely that virus's cause many diseases of unknown etiology, and that new viral pathogens are constantly emerging. The ability to detect and identify novel human viruses is a major roadblock to understanding and impacting diseases associated with these agents. We have developed a collaborative approach that combines the power of viral metagenomics with advances in microfluidics to allow the detection and isolation of individual viruses from complex biological samples, and ultimately to develop a platform that will greatly enhance the ability to detect, isolate and thus rapidly characterize novel pathogens.",7643261;,"WEITZ, DAVID A;","DUGAN, VIVIEN GRACE",02/01/2013,01/31/2015,,Merging Microfludics and Metagenomics for Novel High - throughout Virus Discovery,101291,ISD,Instrumentation and Systems Development Study Section,,,2,259199,
8793360,R21,GM,7,N,02/07/2014,01/01/2014,07/31/2014,859,R21GM100224,SCHOOLS OF MEDICINE,PAR-09-219,7R21GM100224-03,NIGMS:179885\,Research Projects,2013,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"This study, in part, is to determine how osteoclasts acidify the extracellular compartment to degrade bone. Our results will impact our understanding of osteoclast dysfunction, which is the cause of most adult skeletal diseases. Our studies will also help identify new drug targets for the treatment of osteoporosis. 1",8893130;,"GRABE, MICHAEL;","LYSTER, PETER ",09/01/2012,07/31/2014,,Computer simulations of lysosomal and osteoclast microphysiology,100224,MABS,Modeling and Analysis of Biological Systems Study Section,,,3,179885,
8724710,R24,OD,7,N,02/06/2014,02/07/2014,01/31/2015,351,R24OD010928,SCHOOLS OF VETERINARY MEDICINE,,7R24OD010928-11,OD:169419\,Other Research Related,2013,"OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH",,COLUMBIA,UNITED STATES,VETERINARY SCIENCES,09,153890272,US,UNIVERSITY OF MISSOURI-COLUMBIA,MO,65211,,6998020;,"LYONS, LESLIE A;","O'NEILL, RAYMOND R.",04/01/2001,01/31/2015,Age;animal breeding;Animal Genetics;Animal Hospitals;Animal Model;animal model development;Animals;Applications Grants;Area;Asthma;Atrophic;base;Behavior;Behavior Disorders;Biological;Biological Preservation;Biological Process;Biology;Breeding;Canis familiaris;Case-Control Studies;Cat Diseases;cat genome;Chromosome Mapping;Chromosomes;Chronic;Client;Clinical;clinical Diagnosis;Collection;Color;Communicable Diseases;Communities;companion animal;Complex;Consent Forms;Data;Databases;Development;Diabetes Mellitus;Diagnostic;Diagnostic Services;Disease;Disease model;disease phenotype;Disease susceptibility;DNA;DNA Library;DNA Markers;Educational process of instructing;Electronics;Emerging Technologies;Epilepsy;Evaluation;Family;Family Felidae;Felis catus;follow-up;Funding;Funding Agency;Funding Mechanisms;Future;Genes;Genetic;Genetic Heterogeneity;genetic linkage;Genetic Models;Genetic Polymorphism;Genetic Recombination;genetic resource;Genetic screening method;Genome;Genome Scan;genome wide association study;Genomics;Genotype;Germ Cells;Goals;Health;Heart Diseases;Hereditary Disease;Household;Human;human disease;Hypertrophic Cardiomyopathy;improved;Inbreeding;Incidence;Inherited;insight;Institutes;Instruction;interest;Investigation;Kidney Diseases;Knowledge;Laboratories;laboratory cat;Life Style;Linkage Disequilibrium;Linkage Disequilibrium Mapping;Maintenance;Malignant Neoplasms;man;Maps;Methods;Microsatellite Repeats;model development;Modeling;mouse model;Mus;Mutation;National Center for Research Resources;Obesity;Online Systems;Ownership;Pathogenesis;Patient Care;Patients;Pennsylvania;physical mapping;Pituitary Dwarfism;Plague;Polymorphic Microsatellite Marker;Population;prevent;Principal Investigator;Private Practice;programs;Radiation Hybrid Map;Radiation Hybrid Mapping;Records;Registries;Renal carcinoma;Research;research clinical testing;Research Personnel;Research Support;Residencies;Resource Development;Resources;Retinal;Sample Size;Sampling;Scanning;screening;sedentary;Services;Shelter facility;Single Nucleotide Polymorphism;Teaching Hospitals;Technology;Test Result;Testing;tool;Training;Training Programs;trait;Translations;United States;United States National Institutes of Health;Universities;Veterinarians;Veterinary Medicine;Veterinary Schools;Visit;web site;Work,Genetic Mapping Resources for Common Mammalian Diseases,10928,RIRG,Comparative Medicine Review Committee,,,11,169419,