APPLICATION_ID,ACTIVITY,ADMINISTERING_IC,APPLICATION_TYPE,ARRA_FUNDED,AWARD_NOTICE_DATE,BUDGET_START,BUDGET_END,CFDA_CODE,CORE_PROJECT_NUM,ED_INST_TYPE,FOA_NUMBER,FULL_PROJECT_NUM,FUNDING_ICs,FUNDING_MECHANISM,FY,IC_NAME,NIH_SPENDING_CATS,ORG_CITY,ORG_COUNTRY,ORG_DEPT,ORG_DISTRICT,ORG_DUNS,ORG_FIPS,ORG_NAME,ORG_STATE,ORG_ZIPCODE,PHR,PI_IDS,PI_NAMEs,PROGRAM_OFFICER_NAME,PROJECT_START,PROJECT_END,PROJECT_TERMS,PROJECT_TITLE,SERIAL_NUMBER,STUDY_SECTION,STUDY_SECTION_NAME,SUBPROJECT_ID,SUFFIX,SUPPORT_YEAR,TOTAL_COST,TOTAL_COST_SUB_PROJECT 8784490,F30,HD,1,N,09/01/2014,11/16/2014,11/15/2015,865,F30HD081865,SCHOOLS OF MEDICINE,PA-11-110,1F30HD081865-01,NICHD:32486\,"Training, Individual",2014,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,CHAPEL HILL,UNITED STATES,OTHER BASIC SCIENCES,04,,US,UNIV OF NORTH CAROLINA CHAPEL HILL,NC,275990001,"PUBLIC HEALTH RELEVANCE: Activation of apoptosis (programmed cell death) is critical for the development of the embryo, and failure to induce cell death leads to embryonic lethality with significant defects in the nervous system. In this research proposal I will investigate a novel apoptotic pathway engaged by embryonic stem cells and neural precursor cells, the actively dividing cells in the brain that give rise to new neurons. Because birth defects and neurodevelopmental disorders are serious threats to maternal and child health, these studies are essential in clarifying the mechanisms that underlie cell death during embryonic and fetal development. ",10981792;,"NAKAMURA, AYUMI;","HENKEN, DEBORAH B.",11/16/2014,11/15/2018,Animals;Apoptosis;Apoptotic;apoptotic protease-activating factor 1;Bax protein;BCL2 gene;Binding (Molecular Function);Brain;Brain region;Bypass;Caenorhabditis elegans;caspase;caspase-3;caspase-9;Cell Death;Cell Line;cell type;Cells;Cellular biology;Cessation of life;Complex;Congenital Abnormality;cranium;cytochrome c;Cytoplasm;Data;Defect;Development;developmental disease/disorder;Dorsal;Embryo;Embryonic and Fetal Development;Embryonic Development;embryonic stem cell;Event;Exencephalies;Exhibits;Failure (biologic function);Homeostasis;Homologous Gene;Hyperplasia;in vivo;inhibitor/antagonist;Invertebrates;Knockout Mice;Knowledge;Lead;Maintenance;Mammalian Cell;Mass Spectrum Analysis;Maternal and Child Health;Mediating;Mitochondria;Modeling;Mus;nerve stem cell;nervous system disorder;Nervous system structure;neural precursor cell;Neural Tube Closure;Neuraxis;Neurodevelopmental Disorder;Neurons;novel;Organ;Pathogenesis;Pathway interactions;Phenotype;postnatal;pro-apoptotic protein;Protein Isoforms;Proteins;public health relevance;recombinase;Research Proposals;Reverse Transcriptase Polymerase Chain Reaction;small hairpin RNA;Small Interfering RNA;small molecule;Telencephalon;Testing;Tissues;WD Repeat,Identification of a novel apoptotic pathway in the developing mammalian embryo,81865,ZRG1,Special Emphasis Panel,,,1,32486, 8716363,F31,CA,1,N,08/29/2014,09/02/2014,09/01/2015,398,F31CA186444,,PA-11-111,1F31CA186444-01,NCI:34996\,"Training, Individual",2014,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,07,,US,CHILDREN'S HOSPITAL CORPORATION,MA,021155737,"PUBLIC HEALTH RELEVANCE: This proposal will provide insights into the role of a protein called LIN28B in a childhood kidney cancer, Wilms'tumor. Activation of the gene that encodes LIN28B has been documented in a growing list of various cancers, especially those that are highly aggressive and carry the worst prognosis. It is my hope that discovery of Wilms'specific pathways or targets would add considerable depth to our understanding of the large variety of human tumors in which LIN28B has been implicated and may ultimately be important for defining therapeutic approaches. ",11103048;,"YERMALOVICH, ALENA;","SCHMIDT, MICHAEL K",09/02/2014,09/01/2017,Accounting;base;Case Study;Childhood;Childhood Renal Neoplasm;Chromosomal Rearrangement;Chromosomal translocation;Development;Diagnosis;Embryo;Epigenetic Process;Family;Frequencies (time pattern);fusion gene;Gene Activation;Gene Fusion;Genes;Genetic;Genomics;glucose metabolism;Goals;Human;In Vitro;in vivo;insight;Kidney;Laboratories;Lead;Light;Malignant Neoplasms;Maps;MicroRNAs;Molecular;mouse model;Mus;Mutation;Nephroblastoma;nephrogenesis;novel;Organ;outcome forecast;overexpression;Pathogenesis;Pathway interactions;Patients;Pattern;Play;precursor cell;Process;Proteins;public health relevance;Renal carcinoma;Renal Tissue;RNA-Binding Proteins;Role;Sampling;stem cell biology;Stem cells;Sum;Therapeutic;tumor;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation (Physiology);WT1 gene,THE ROLE OF LIN28B IN WILMS TUMOR,186444,ZRG1,Special Emphasis Panel,,,1,34996, 8719525,F31,CA,1,N,09/12/2014,09/15/2014,09/14/2015,398,F31CA186625,SCHOOLS OF MEDICINE,PA-11-112,1F31CA186625-01,NCI:42676\,"Training, Individual",2014,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,FAMILY MEDICINE,02,,US,DARTMOUTH COLLEGE,NH,037551404,"PUBLIC HEALTH RELEVANCE: We will develop and evaluate a novel data analysis algorithm in order to more accurately classify ovarian cancer tumor samples into subtypes. This more accurate classification will allow for better understanding of risk factors that are associated wit each subtype, and will move research in personalized treatment forward. ",11803689;,"RUDD, JAMES;","VALLEJO-ESTRADA, YOLANDA ",09/15/2014,09/14/2018,Address;African American;Algorithms;Automobile Driving;base;Bioinformatics;Biological;Biomedical Research;cancer epidemiology;Cancer Etiology;cancer health disparity;career;Caucasians;Caucasoid Race;Cessation of life;Characteristics;Classification;Consensus;Data;Data Analyses;Data Set;Decision Trees;Diagnosis;Epidemiology;experience;Experimental Designs;forest;Gene Expression;Gene Expression Profile;Genes;Genome;Glioblastoma;improved;Individual;Knowledge;knowledge base;Learning;Light;Malignant neoplasm of ovary;member;Methodology;Methods;Modeling;Molecular;multidisciplinary;Names;novel;ovarian neoplasm;Pathway interactions;Performance;Phenotype;Population;Population Heterogeneity;Positioning Attribute;Process;Protocols documentation;public health relevance;Publishing;Reporting;Research;Risk Factors;Sampling;Science;Serous;Simulate;simulation;skills;Testing;The Cancer Genome Atlas;Training;tumor;United States;Validation;Wit;Woman,Refining ovarian cancer subtype classifiers to incorporate biologic features,186625,ZRG1,Special Emphasis Panel,,,1,42676, 8837131,F31,CA,1,N,09/15/2014,09/30/2014,09/29/2015,398,F31CA192874,SCHOOLS OF MEDICINE,PA-14-148,1F31CA192874-01,NCI:33648\,"Training, Individual",2014,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,PEDIATRICS,11,,US,CASE WESTERN RESERVE UNIVERSITY,OH,441067015,PUBLIC HEALTH RELEVANCE: Metastatic tumors affect a wide variety of patient populations and are difficult to treat because of their immune modulating capabilities to induce immune tolerance. Tumor-infiltrating lymph node metastasis is a diagnostic tool used by oncologist to predict clinical outcomes. This project will incorporation the use of inflammatory chemokines in the tumor-infiltrating lymph node microenvironment and real-time dynamic in vivo cellular interaction measurement tools to study the ability of inflammatory chemokines to overcome immune tolerance against metastatic tumor and to provide a rationale for incorporating these chemokines to enhance immunotherapeutic efficacy against cancer. ,11363411;,"ALLEN, FREDERICK;","VALLEJO-ESTRADA, YOLANDA ",09/30/2014,09/29/2017,Adjuvant;Advanced Malignant Neoplasm;Affect;Antigens;Attention;B-Lymphocytes;base;Biological;cancer immunotherapy;CCL3 gene;CCL4 gene;CD8B1 gene;Cell Communication;Cell Maturation;Cells;chemokine;chemokine receptor;Clinical;Clinical Data;Colon Adenocarcinoma;Colonic Neoplasms;conditioning;Dendritic Cells;Development;Diagnostic;Environment;Event;Exhibits;Exposure to;Failure (biologic function);Fluorescence-Activated Cell Sorting;Generations;Histology;Homeostasis;Immune;immune activation;Immune response;Immune Tolerance;Immunocompetent;immunogenic;immunogenicity;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injection of therapeutic agent;Kinetics;Lead;Life;Link;lymph nodes;Lymphocyte;Macrophage Inflammatory Protein-1;Malignant Neoplasms;Measurement;Memory;Metastatic Neoplasm to Lymph Nodes;Metastatic to;Microscopy;migration;Modeling;Mus;Neoplasm Metastasis;neoplastic cell;novel;Oncologist;Outcome;patient population;Patients;Pilot Projects;Process;public health relevance;Reaction Time;receptor expression;Recruitment Activity;research study;response;Role;Sampling;Self-control as a personality trait;Specificity;stem;T cell response;T memory cell;T-Lymphocyte;Therapeutic;Therapeutic Uses;Time;Tissues;tool;Translating;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;two-photon;Vaccinated;Vaccines;Work,INFLAMMATORY CHEMOKINE CCL3 IN THE TUMOR MICROENVIRONMENT LEADS TO ENHANCED ANTITUMOR IMMUNE DEVELOPMENT IN THE DRAINING LYMPH NODE,192874,ZRG1,Special Emphasis Panel,,,1,33648, 8717256,F31,EB,1,N,09/26/2014,11/16/2014,11/15/2015,286,F31EB018720,BIOMED ENGR/COL ENGR/ENGR STA,PA-11-111,1F31EB018720-01,NIBIB:36276\,"Training, Individual",2014,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,NEW HAVEN,UNITED STATES,ENGINEERING (ALL TYPES),03,,US,YALE UNIVERSITY,CT,065103209,"PUBLIC HEALTH RELEVANCE: The proposed research aims to improve the clinical viability of kinetic parameter estimation from dynamic positron emission tomography (PET) images through the development of a novel 4- dimensional parametric image reconstruction algorithm to provide substantially less noisy parameter estimates than the current standard, without sacrificing accuracy. Such a reconstruction algorithm will allow lower radiation dose to patients, shorter imaging scan times, and higher image resolution, while still providing valuable quantitative information for a variety of clinical PET applications, specifically including the measurement of myocardial blood flow and coronary flow reserve from dynamic cardiac images. ",11900174;,"GERMINO, MARY;","ERIM, ZEYNEP ",11/16/2014,11/15/2016,Algorithms;base;Behavior;Blood;Blood flow;Brain imaging;Cardiac;Clinical;Clinical Research;clinically relevant;Coronary;Data;Development;disease diagnosis;Dose;Four-dimensional;Goals;Half-Life;Human;Hybrids;Image;Image Reconstructions;imaging modality;improved;Individual;interest;Kinetics;Lead;Left ventricular structure;Liver;Low Dose Radiation;Lung;Measurement;Measures;Metabolism;Methods;Modeling;Monitor;Myocardial;Myocardial tissue;Myocardium;Noise;novel;Patients;Pharmacology;Physiological;Physiological Processes;Population;Positron-Emission Tomography;pre-clinical;Protocols documentation;public health relevance;Radioactivity;Radiopharmaceuticals;receptor;reconstruction;Research;research study;Resolution;Right ventricular structure;Rubidium;Sampling;Scanning;Series;Signal Transduction;Simulate;simulation;Specific qualifier value;Testing;Time;Tissues;tool;Tracer;uptake;Vascular blood supply,Hybrid parametric/non-parametric direct reconstruction for dynamic PET,18720,ZRG1,Special Emphasis Panel,,,1,36276, 8838592,F31,EB,1,N,09/23/2014,11/16/2014,11/15/2015,286,F31EB019883,SCHOOLS OF MEDICINE,PA-14-148,1F31EB019883-01,NIBIB:40038\,"Training, Individual",2014,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,NEW YORK,UNITED STATES,ADMINISTRATION,,,US,WEILL MEDICAL COLL OF CORNELL UNIV,NY,100654805,"PUBLIC HEALTH RELEVANCE: A big barrier to effective cancer therapy using nanoparticles is the inability to confirm and quantify drug delivery at the target. This project will investigate th use of quantitative susceptibility mapping (QSM), a novel magnetic resonance imaging (MRI) technique, to map the whole body distribution of super paramagnetic iron oxide (SPIO) particles loaded with Paclitaxel in a mouse. ",12087116;,"DEH, KOFI;","ERIM, ZEYNEP ",11/16/2014,11/15/2016,Address;Algorithms;base;Biological Process;cancer therapy;Cancerous;Cells;Clinical;Contrast Media;Data;data acquisition;density;Diagnosis;Diagnostic;Disease;Dose;Drug Delivery Systems;Effectiveness;Elements;Event;extracellular;Fatty acid glycerol esters;Financial compensation;Gadolinium;gadolinium oxide;Gene Targeting;Geometry;Health;Image;Imagery;imaging modality;Imaging Techniques;in vivo;in vivo imaging;iron oxide;Lead;magnetic field;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Methods;Molecular;molecular imaging;Monitor;Motion;Mus;nanomedicine;nanoparticle;neglect;neoplastic cell;Noise;novel;novel strategies;optic imaging;Paclitaxel;particle;Pharmaceutical Preparations;Phase;Predisposition;Proteins;Relaxation;Reproducibility;Research;Signal Transduction;Site;Source;Techniques;Technology;Therapeutic;Therapeutic Agents;Tissues;tool;Water;water environment;Weight;Work,Imaged guided drug delivery,19883,ZRG1,Special Emphasis Panel,,,1,40038, 8783212,F31,GM,1,N,07/31/2014,09/01/2014,08/31/2015,859,F31GM112370,SCHOOLS OF MEDICINE,PA-11-112,1F31GM112370-01,NIGMS:34786\,"Training, Individual",2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,BIOLOGY,07,,US,HARVARD MEDICAL SCHOOL,MA,02115,"PUBLIC HEALTH RELEVANCE: The expression of our genes is a conserved process required for the development and growth of all organisms. The first major step at which gene expression is regulated is transcription, the process of copying genetic information from DNA to RNA. Misregulation of transcription can result in a broad range of diseases, including cancer and Alzheimer's disease;therefore, this proposal aims to understand how this process can go awry by studying the effects caused by defective factors involved in the regulation of transcription using yeast as a tractable tool. ",11651221;,"REIM RODRIGUEZ, NATALIA ISABEL;","GAILLARD, SHAWN R.",09/01/2014,08/31/2017,Address;Alzheimer's Disease;Animal Model;Binding (Molecular Function);Biochemical;Biological Assay;C-terminal;casein kinase;casein kinase II;Chromatin;Codependence;Complex;Consensus;Dependency (Psychology);Disease;DNA;Elongation Factor;Event;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Growth and Development function;Histone H3;histone modification;Human;In Vitro;in vivo;insight;Lead;Learning;Link;Malignant Neoplasms;Mammalian Cell;Maps;Measures;Mediating;member;Molecular;mutant;Nature;Organism;Phosphorylation;Play;Process;public health relevance;Regulation;research study;RNA;RNA Polymerase II;RNA polymerase II largest subunit;Role;Saccharomyces cerevisiae;Site;Staging;System;Testing;tool;Transcription Elongation;transcription factor;Transcription Process;Transcriptional Regulation;transcriptome sequencing;Yeasts,Functional analysis of the conserved transcription elongation factor Spn1,112370,ZRG1,Special Emphasis Panel,,,1,34786, 8784869,F31,MH,1,N,06/16/2014,09/05/2014,09/05/2015,242,F31MH105217,SCHOOLS OF MEDICINE,PA-11-111,1F31MH105217-01,NIMH:37121\,"Training, Individual",2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,NEUROSCIENCES,13,,US,ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI,NY,100296574,PUBLIC HEALTH RELEVANCE: Depression in a major health issue in the United States that lacks both sufficient therapeutic strategies and satisfactory understanding of neuropathology. This proposal will explore the role of microRNAs in regulating inflammation and depression-like behavior in a rodent repeated stress model. The proposed studies will provide a better understanding of the role of the peripheral immune system in depression and inform more effective therapeutic strategies. ,11081059;,"PFAU, MADELINE LEAH;","ROSEMOND, ERICA K",09/05/2014,09/04/2016,Affect;American;Animal Model;Asthma;B-Lymphocytes;base;Basic Science;Basophils;Behavior;Behavioral;Biological Assay;Bone Marrow;Bone Marrow Transplantation;cell type;Cells;Chronic;cytokine;Data;Depressed mood;Development;disability;Disease;Disease remission;Disease susceptibility;eosinophil;Etiology;Exhibits;expression vector;Family;Family member;Fluorescence-Activated Cell Sorting;Health;Hematopoietic;Hematopoietic stem cells;Human;Immune system;In Vitro;Inflammation;Inflammatory;Interleukin-6;Knowledge;Leukocytes;Luciferases;Major Depressive Disorder;Measures;Mediating;Mental Depression;Messenger RNA;MicroRNAs;Modeling;Molecular;Molecular Profiling;monocyte;Multiple Sclerosis;Mus;Neuraxis;Neuroblastoma;neuropathology;neutrophil;novel;novel therapeutics;overexpression;Patients;Pattern;Peripheral;peripheral blood;Post-Transcriptional Regulation;Predisposition;prevent;progenitor;public health relevance;Regulation;Relative (related person);Repression;research study;resilience;Resistance;response;Rodent;Role;Serum;social;social stress;Sorting - Cell Movement;Stem cells;Stress;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Tissues;Transplantation;United States;Wild Type Mouse,Role of leukocyte-derived microRNAs in stress-induced inflammation and depression,105217,ZRG1,Special Emphasis Panel,,,1,37121, 8830095,F31,MH,1,N,09/24/2014,11/16/2014,11/15/2015,242,F31MH106321,SCHOOLS OF MEDICINE,PA-14-147,1F31MH106321-01,NIMH:42676\,"Training, Individual",2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,07,,US,NORTHWESTERN UNIVERSITY AT CHICAGO,IL,606113152,"PUBLIC HEALTH RELEVANCE: Twelve-month prevalence rates indicate that 21-30 million Americans will require treatment for depression each year, needs that will never be able to be met with standard one-on-one intensive treatments. The proposed research takes an innovative approach to extending care capacity and informing design of future interventions though usability testing on existing mobile application (app) features and evaluating the comparative outcomes of two treatments for depression delivered via mobile apps. Knowledge gained from this project has immense potential to extend care capacity to millions of individuals with empirically supported treatment. ",11092058;,"STILES-SHIELDS, COLLEEN;","HILL, LAUREN D.",11/16/2014,11/15/2016,Address;Aftercare;American;arm;Australia;base;Behavior Therapy;Behavioral;behavioral health;Car Phone;care systems;Caucasians;Caucasoid Race;Characteristics;Cognitive;Cognitive Therapy;combat;comparative;comparative trial;cost;Data;Depressive disorder;depressive symptoms;design;disability;Elements;Employee Assistance Program (Health Care);engineering design;Epidemic;ethnic minority population;Feasibility Studies;follow-up;Future;Goals;handheld mobile device;Health;health application;Health Services Accessibility;Healthcare Systems;high risk;improved;Individual;Industry;innovation;Internet;Intervention;Knowledge;Literature;Long-Term Care;Measures;meetings;Mental Depression;Mental disorders;Mental Health;Methods;mHealth;mobile application;Modeling;Monitor;Moods;Morbidity - disease rate;Mortality Vital Statistics;Nature;Online Systems;Outcome;Participant;Patients;Prevalence;Process;Psyche structure;psychologic;Psychological Theory;Psychology;public health relevance;Randomized;randomized trial;Research;Research Personnel;Research Training;Staging;System;Technology;Telephone;Testing;theories;Time;tool;Translating;Translations;usability;Veterans;visual feedback;Work,Mobile Applications for Depression: Comparing Cognitive and Behavioral Approaches,106321,ZMH1,Special Emphasis Panel,,,1,42676, 8831817,F31,NS,1,N,09/21/2014,09/24/2014,09/23/2015,853,F31NS087716,SCHOOLS OF MEDICINE,PAR-13-127,1F31NS087716-01A1,NINDS:42676\,"Training, Individual",2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MILWAUKEE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,,US,MEDICAL COLLEGE OF WISCONSIN,WI,532263548,"PUBLIC HEALTH RELEVANCE: Sickle cell disease is a common genetic disorder that causes red blood cells to occlude blood vessels, resulting in very painful episodes. This proposal will study how an immune system mediator influences the pain-sensing pathways in patients with sickle cell disease. ",11042908;,"ZAPPIA, KATHERINE JAHNELLE HENDLEY;","PORTER, LINDA L",09/24/2014,09/23/2016,Acute;Acute Pain;Address;Adult;Affect;Afferent Neurons;Animal Model;base;Behavioral;Behavioral Assay;behavioral sensitization;Binding (Molecular Function);Blood Vessels;Calcium;CCL4 gene;cell body (neuron);chemokine;Chronic;chronic pain;Complex;Data;Development;Disease;Electrophysiology (science);Elements;Erythrocytes;Esthesia;Exhibits;experience;Extracellular Matrix Proteins;Fiber;Frequencies (time pattern);Generations;Glycoproteins;Goals;Hereditary Disease;Human;Hyperalgesia;Hypersensitivity;Hypoxia;Image;Immune system;in vivo;Inflammation Mediators;inflammatory neuropathic pain;insight;Ions;Isolectin;Ligands;Link;Maintenance;mechanical drive;Mechanics;Mediating;Mediator of activation protein;Mentors;Methods;Mission;monocyte chemoattractant protein 1 receptor;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Nerve Fibers;Neurologic;Neurons;novel therapeutics;Nursing Faculty;Pain;pain behavior;Pain Disorder;painful neuropathy;patch clamp;Patch-Clamp Techniques;Pathway interactions;Patients;Phenotype;Physicians;Population;prevent;public health relevance;receptor;Reporting;Research;Research Activity;Role;Scientist;Sensory;Severities;Sickle Cell;Sickle Cell Anemia;sickling;Signal Transduction;Spinal Ganglia;Stimulus;Syndrome;Techniques;Touch sensation;Training;Underserved Population;Vanilloid;Withdrawal,The Role of Chemokine Signaling in Sickle Cell Pain,87716,NST,Neurological Sciences Training Initial Review Group,,A1,1,42676, 8781306,F32,AI,1,N,07/15/2014,07/16/2014,07/15/2015,855,F32AI114029,SCHOOLS OF MEDICINE,PA-11-113,1F32AI114029-01,NIAID:49850\,"Training, Individual",2014,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,GENETICS,07,,US,UNIVERSITY OF WASHINGTON,WA,981959472,"PUBLIC HEALTH RELEVANCE: The Gram-negative bacterium Acinetobacter baumannii is one of the most frequent causes of hospital- acquired respiratory, blood, burn, and wound infections. This proposal uses genetic and biochemical techniques to identify and characterize genes involved in A. baumannii desiccation tolerance. This phenotype plays a major role in A. baumannii transmission via contaminated surfaces and healthcare workers'hands. The results from these studies will provide a basic understanding of this pathogen's environmental lifestyle and may lead to new strategies for preventing and containing infections. ",12037703;,"HUSE, HOLLY KRISTEN;","KORPELA, JUKKA K.",07/16/2014,07/15/2017,Acinetobacter baumannii;Afghanistan;Anabolism;Antibiotic Resistance;Biochemical;Biochemistry;Blood;Burn injury;Cells;Cellular Stress Response;Complex;Cyanobacterium;Desiccation;Disease Outbreaks;Economic Burden;Environment;Excision;Financial cost;Genes;Genetic;Genetic Determinism;Goals;Gram-Negative Bacteria;Hand;health care economics;Health Personnel;Hospitals;Infection;Iraq;Lead;Life Style;macromolecule;Mediating;Medical Device;Methods;Modeling;Molecular;Morbidity - disease rate;Mortality Vital Statistics;Mus;mutant;Nosocomial Infections;novel;Organism;pathogen;Pathway interactions;Patients;Phenotype;Play;Pneumonia;prevent;Prevention;Process;Production;public health relevance;respiratory;response;RNA Sequences;Role;Septicemia;Soldier;solute;Source;Surface;Techniques;Testing;trait;transcriptome sequencing;transmission process;United States;Up-Regulation (Physiology);Ventilator;Virulence;Water;wound;Wound Infection;Wounds and Injuries,Genetic determinants of Acinetobacter baumannii desiccation tolerance,114029,ZRG1,Special Emphasis Panel,,,1,49850, 8649551,F32,CA,1,N,07/29/2014,09/01/2014,08/31/2015,398,F32CA171911,SCHOOLS OF MEDICINE,PA-11-113,1F32CA171911-01A1,NCI:58946\,"Training, Individual",2014,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,BIOLOGY,02,,US,UNIVERSITY OF PENNSYLVANIA,PA,191046205,"PUBLIC HEALTH RELEVANCE: We have previously shown that oncogene expression leads to an increased reliance on the ATR-Chk1 pathway for maintenance of genome stability and cell viability. Oncogenes can lead to increased Aurora-Plk1 pathway hyperactivation. The studies proposed in this grant will determine both whether ATR suppression, alone or in combination with Aurora-Plk1 activation, will serve as a novel therapy for cancer and whether Aurora-Plk1 over stimulation will serve as a positive prognostic indicator of response to ATR inhibitor based therapies. ",10545897;,"RAGLAND, RYAN;","JAKOWLEW, SONIA B",09/01/2014,08/31/2015,adenoma;Affect;Animals;base;Biological;Biological Models;c-myc Genes;cancer therapy;Cell Communication;Cell Culture System;Cell Cycle Regulation;Cell Line;Cell Survival;Cells;Checkpoint kinase 1;Colon;Colon Carcinoma;Dependence;Detection;Development;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;Environment;Equilibrium;Event;Exhibits;Failure (biologic function);Genetic;Genome;Genome Stability;Grant;Health;HRAS gene;Human Cell Line;human PLK1 protein;human STK6 protein;in vivo;in vivo Model;inhibitor/antagonist;Intestines;Killings;Lead;Maintenance;Malignant Neoplasms;Measures;Mediating;Modeling;Monitor;Mus;Mutation;Nature;Neoplasm Transplantation;novel;Nude Mice;Null Lymphocytes;Oncogenes;Oncogenic;overexpression;oxidative DNA damage;Pathway interactions;PLK1 gene;premature;prevent;Procedures;Process;Prognostic Marker;Recovery;Refractory;Reliance;Repression;Research;research study;response;S Phase;Staging;Stress;System;Testing;Therapeutic;Transplantation;tumor;Tumor Cell Line;tumor initiation;tumor progression;tumorigenesis;Ubiquitination;Work,Sensitization of cancers to ATR inhibition via elevated Aurora A-PLK1 activity,171911,ZRG1,Special Emphasis Panel,,A1,1,58946, 8783438,F32,DK,1,N,05/20/2014,07/01/2014,06/30/2015,847,F32DK103453,,PA-11-113,1F32DK103453-01,NIDDK:55094\,"Training, Individual",2014,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,07,,US,DANA-FARBER CANCER INST,MA,022155450,"PUBLIC HEALTH RELEVANCE: Using genetic and bioinformatics tools, we propose to understand how the fast growing intestinal stem cells control gene expression through epigenetic mechanisms. Our study will lead to a detailed understanding of the chromatin basis for rapid growth, function and regeneration of the intestinal mucosa. This knowledge is highly relevant to developing new diagnostic strategies and drugs for effective treatment of colorectal cancer and inflammatory bowel diseases faced by more than 1.5 million Americans every year. ",12002747;,"JADHAV, UNMESH;","PODSKALNY, JUDITH M,",07/01/2014,06/30/2017,Adult;Affect;American;Apoptosis;Apoptotic;base;Bioinformatics;Biological Assay;Cancer cell line;Cell Differentiation process;Cell Maintenance;Cell physiology;cell type;Cells;Chip seq;Chromatin;chromatin modification;Colorectal Cancer;Complex;crypt cell;Data;Defect;Development;Disease;drug development;Drug Targeting;Ectopic Expression;effective therapy;Electron Microscopy;embryonic stem cell;Enhancer Elements (Genetics);Enzymes;Epigenetic Process;Epithelial Cells;EZH2 gene;Gene Components;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;genome wide association study;histone modification;Histones;Human;In Vitro;in vivo;Individual;Inflammatory Bowel Diseases;insight;intestinal crypt;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestinal Mucosa;intestinal villi;Intestines;Knockout Mice;Knowledge;Lead;Length;Maintenance;Malignant Neoplasms;Mammalian Cell;Maps;Mass Spectrum Analysis;Measures;Mediating;Modification;mouse model;Mus;mutant;Mutate;Natural regeneration;novel diagnostics;Null Lymphocytes;overexpression;Pattern;Pharmaceutical Preparations;Phenotype;Play;Polycomb;Population;Positioning Attribute;Process;progenitor;programs;Proliferating;Promotor (Genetics);protein complex;public health relevance;rapid growth;Role;self-renewal;Signal Pathway;Signaling Pathway Gene;stem;stem cell differentiation;Stem cells;Time;Tissue-Specific Gene Expression;Tissues;tool;transcriptome sequencing;Validation;Villus;Work,Role of histone H3K27me3 mark in intestinal homeostasis,103453,ZDK1,Special Emphasis Panel,,,1,55094, 8784091,F32,EY,1,N,09/12/2014,09/16/2014,09/15/2015,867,F32EY023906,,PA-11-113,1F32EY023906-01A1,NEI:53282\,"Training, Individual",2014,NATIONAL EYE INSTITUTE,,LA JOLLA,UNITED STATES,,49,,US,SALK INSTITUTE FOR BIOLOGICAL STUDIES,CA,920371002,"PUBLIC HEALTH RELEVANCE: Understanding the function of detailed connections between neurons is necessary to obtain an adequate understanding of the function of neural networks in the cerebral cortex. Many diseases, such as Parkinson's disease, neuromuscular disorders, paralysis, schizophrenia, depression, autism, and attention disorders, are caused by dysfunction of precise neural networks. Understanding how these networks work is therefore likely to provide much insight into these diseases. ",8877738;,"RICHLER, ESTHER;","AGARWAL, NEERAJ ",09/16/2014,09/15/2017,Address;Affect;Animals;Antibodies;area striata;Attention;Autistic Disorder;Autopsy;base;Biological Neural Networks;Brain;Calcium;cell type;Cells;Cerebral cortex;Characteristics;Complex;Data;design;Disease;Distant;DNA;Electroporation;excitatory neuron;Frequencies (time pattern);Functional disorder;Health;hippocampal pyramidal neuron;Image;In Vitro;in vivo;Infection;information processing;inhibitory neuron;insight;Interneurons;Label;Life;Light;Link;Location;Maps;Measures;Mental Depression;Methodology;Methods;Mus;Nervous System Physiology;Neuromuscular Diseases;Neurons;novel;orientation selectivity;Output;Paralysed;Parkinson Disease;Parvalbumins;Pattern;Photic Stimulation;Play;Population;Positioning Attribute;postsynaptic;preference;presynaptic;Process;Property;public health relevance;Publishing;Rabies;Rabies virus;receptive field;Research;research study;response;Rodent;Role;Schizophrenia;Sensory;Shapes;Somatostatin;Source;Staining method;Stains;Structure;Synapses;System;Testing;two-photon;Visual;Visual Cortex;visual information;visual stimulus;Work,Functional connectivity of isolated neuronal circuits in primary visual cortex,23906,ZRG1,Special Emphasis Panel,,A1,1,53282, 8710539,F32,GM,1,N,08/01/2014,08/01/2014,07/31/2015,859,F32GM108298,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,1F32GM108298-01A1,NIGMS:51530\,"Training, Individual",2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,CHEMISTRY,12,,US,UNIVERSITY OF MICHIGAN,MI,481091274,"PUBLIC HEALTH RELEVANCE: The acidic environment of the mammalian stomach poses a natural barrier of defense against invading microorganisms. As disease-causing enteric bacteria pass through the stomach, the chaperone HdeA is activated by the low pH environment and promotes bacterial survival by preventing acid-induced aggregation of other proteins. Our work will achieve an atomic-level description of how HdeA protects unfolded proteins during acid stress and releases them upon return to non-stress conditions. ",10524010;,"AHLSTROM, LOGAN S;","SAKALIAN, MICHAEL ",08/01/2014,07/31/2016,Accounting;acid stress;Acids;Address;base;Binding (Molecular Function);Biochemical;Biochemistry;Biological Assay;Biomolecular Nuclear Magnetic Resonance;Cell physiology;Cereals;Charge;Chemicals;Collaborations;Complex;conformer;Data;design;dimer;Disease;Dissociation;Enterobacteriaceae;Environment;Equilibrium;Event;Exhibits;Experimental Designs;flexibility;Fluorescence Resonance Energy Transfer;fly;gain of function;Goals;Health;Immunity;insight;Invaded;member;Methods;Michigan;microorganism;Modeling;models and simulation;Molecular;Molecular Chaperones;molecular dynamics;monomer;multi-scale modeling;mutant;Nature;novel;Nuclear Magnetic Resonance;Pathogenicity;Periplasmic Proteins;Play;prevent;Protein Dynamics;protein function;protein structure;Proteins;protonation;Relative (related person);Reporting;Research;research study;Residual state;Resistance;response;Role;Sampling;sensor;Simulate;simulation;Specialist;Stomach;Stress;Structure;Substrate Interaction;Testing;Time;Universities;Work,The Role of Conditional Disorder in the Acid Stress-Sensing Chaperone HdeA,108298,ZRG1,Special Emphasis Panel,,A1,1,51530, 8783145,F32,GM,1,N,07/15/2014,08/16/2014,08/15/2015,859,F32GM112284,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,1F32GM112284-01,NIGMS:51530\,"Training, Individual",2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAMPAIGN,UNITED STATES,CHEMISTRY,13,,US,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,IL,618207406,"PUBLIC HEALTH RELEVANCE: Protein-protein interactions can play important roles in human disease. However, disrupting specific protein-protein interactions with drug-like small molecules can be challenging. This proposal outlines a method to exploit naturally occurring biosynthetic machinery to evolve novel peptide-based molecules capable of binding specific proteins and disrupting their interactions. ",12042376;,"WALKER, MARK CHALFANT;","BARSKI, OLEG ",08/16/2014,08/15/2017,Affinity;Agglutinins;angiogenesis;Antineoplastic Agents;Apoptosis;Bacteria;Bacteriophages;base;Binding (Molecular Function);Biological Factors;Biological Process;Cell division;Cell Separation;Cell Wall;Cells;combinatorial;crosslink;Cysteine;Dehydration;design;Development;Dimerization;directed evolution;Disease;Disulfides;DNA Library;Endoplasmic Reticulum;Enzymes;ERBB2 gene;Evolution;flexibility;Fluorescence;Fluorescence-Activated Cell Sorting;Gene Library;Generations;Genes;Genome;Human;human disease;Human Genome;Hydrocarbons;In Vitro;Infection;Label;lacticin 481;lanthionine;Length;Libraries;Malignant Neoplasms;Marines;Methods;Names;Nature;novel;Parasites;Partner in relationship;Peptide Hydrolases;Peptide Library;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Play;Predisposition;Process;Prochlorococcus;Production;Protein Binding;protein protein interaction;Proteins;Proteolysis;Proteome;public health relevance;Randomized;Resistance;Ribosomes;Roche brand of trastuzumab;Role;Route;Saccharomyces cerevisiae;screening;Serine;Signal Transduction;small molecule;success;Sulfhydryl Compounds;Surface;System;Therapeutic;thioether;Threonine;tool;Yeasts,Targeting protein-protein interactions through directed evolution of lanthipeptid,112284,ZRG1,Special Emphasis Panel,,,1,51530, 8835598,F32,HG,1,N,11/14/2014,11/19/2014,,172,F32HG008330,SCHOOLS OF MEDICINE,PA-14-149,1F32HG008330-01,NHGRI:51530\,"Training, Individual",2015,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,STANFORD,UNITED STATES,GENETICS,18,,US,STANFORD UNIVERSITY,CA,943041222,"PUBLIC HEALTH RELEVANCE: Genome-scale sequencing technologies are increasingly enabling studies of genetic variation in large numbers of patients and other individuals. However, interpreting the clinical significance of the hundreds of thousands of genetic variants identified in these studies remains a critical challenge. This project will provide useful tools to improve automated prediction of the clinical significance of such genetic variants as well as their regulatory effects on gene expression. ",12034663;,"IOANNIDIS, NILAH MONNIER;","JUNKINS, HEATHER ",11/19/2014,,Address;Affect;Algorithms;Amino Acid Sequence;base;Biological;Biometry;Categories;Cell physiology;Characteristics;Clinical;clinically significant;Communities;Computer Simulation;Computing Methodologies;Consensus;Data Set;Databases;Development;Disease;Elements;Epidemiology;European;exome sequencing;Exons;follow-up;forest;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;Genome;genome sequencing;Genomics;Genotype;Goals;Histocompatibility Testing;Human;Human body;improved;Individual;insight;Joints;lymphoblastoid cell line;Machine Learning;Mentorship;Methods;Modeling;novel;Organized by Structure Protein;Patients;Performance;Phenotype;Population;Positioning Attribute;predictive modeling;Probability;professor;Prostate;Protein Isoforms;protein structure;public health medicine (field);public health relevance;Quantitative Trait Loci;Regulation;Relative (related person);Reporting;Research Personnel;RNA;RNA Splicing;Specificity;Spliced Genes;Staging;Technology;Testing;Tissues;tool;Training;Transcript;Transcription Initiation Site;Universities;Variant;Variation (Genetics),Inferring the effects of genetic variants on gene expression and splicing,8330,ZRG1,Special Emphasis Panel,,,1,51530, 8717259,F32,HL,1,N,05/07/2014,07/14/2014,07/13/2015,837,F32HL123267,SCHOOLS OF MEDICINE,PA-11-113,1F32HL123267-01,NHLBI:55094\,"Training, Individual",2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,,11763598;,"SUN, KAI-HUI;","COLOMBINI-HATCH, SANDRA ",07/14/2014,05/31/2016,Animal Model;Attenuated;Automobile Driving;base;Binding (Molecular Function);Biological Assay;Bleomycin;Blocking Antibodies;Carbon Tetrachloride;Cell Separation;cell type;Cells;Characteristics;Clinical;Collagen;cytokine;Data;Deposition;Development;Disease;Disease Progression;Epithelium;Event;Extracellular Matrix;Family;Fibroblasts;fibrogenesis;Fibrosis;Genetic;Goals;Healthcare;Hydroxyproline;In Vitro;in vivo;indium-bleomycin;inhibitor/antagonist;insight;Integrins;interest;Kidney;Laboratories;Literature;Liver Fibrosis;Lung;Lung Inflammation;lung injury;Mediating;Mediator of activation protein;Modeling;Mus;Myofibroblast;new therapeutic target;Organ;Organ failure;PDGFRB gene;Pericytes;Platelet-Derived Growth Factor Receptor;Population;Process;Production;progenitor;protective effect;public health relevance;Pulmonary Fibrosis;receptor;Reporter;Research;Research Infrastructure;research study;Role;Sirius Red F3B;small molecule;Solid;Staining method;Stains;stem;Structure of parenchyma of lung;System;Techniques;Therapeutic Agents;Tissues;tool;Transforming Growth Factors;Ureteral obstruction,The role of alpha-v integrins on activated fibroblasts in pulmonary fibrosis,123267,ZRG1,Special Emphasis Panel,,,1,55094, 8784640,F32,MH,1,N,07/14/2014,09/01/2014,08/31/2015,242,F32MH102009,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,1F32MH102009-01A1,NIMH:53282\,"Training, Individual",2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,PROVIDENCE,UNITED STATES,MISCELLANEOUS,01,,US,BROWN UNIVERSITY,RI,029129002,"PUBLIC HEALTH RELEVANCE: This project will examine how dopamine levels in prefrontal regions of the brain affect the influence of unexpected events on neural circuits and behavior. The results from this project are likely to change the way that we think about mental disorders such as ADHD and schizophrenia, which are thought to involve an imbalance of dopamine signaling and might even provide insights into how various symptoms of these disorders could be treated. ",9509668;,"NASSAR, MATTHEW;","DESMOND, NANCY L",09/01/2014,08/31/2017,abstracting;Accounting;Address;Affect;Animals;Anterior;Area;Attention deficit hyperactivity disorder;Automobile Driving;Basal Ganglia;base;Behavior;Behavioral;behavioral pharmacology;Biological;Biology;biophysical model;Brain;Brain region;cingulate cortex;Computer Simulation;Corpus striatum structure;Data;Disease;Dopamine;dopaminergic neuron;Dorsal;Electroencephalography;Elements;Employee Strikes;Environment;Event;expectation;experience;Failure (biologic function);Feedback;Future;Genotype;Glean;Goals;Human;human subject;improved;insight;Lead;learned behavior;Learning;Learning Module;Maintenance;Measurement;Measures;Medial;Mediating;Mental disorders;Modeling;N-Methylaspartate;network models;neural circuit;Neurons;Outcome;Pattern;Play;Prefrontal Cortex;Probability;Process;Protocols documentation;Psychological reinforcement;public health relevance;Recurrence;research study;response;Rewards;Role;Schizophrenia;Side;Signal Transduction;Simulate;Speed (motion);Statistical Models;Symptoms;System;Testing;tolcapone;tool;Training;Uncertainty;Update;Ventral Striatum;Work,Does prefrontal dopamine modulate error signals to optimally adjust learning?,102009,ZRG1,Special Emphasis Panel,,A1,1,53282, 8835874,F32,MH,1,N,09/03/2014,11/16/2014,11/15/2015,242,F32MH103960,SCHOOLS OF MEDICINE,PA-14-149,1F32MH103960-01A1,NIMH:53432\,"Training, Individual",2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,PHILADELPHIA,UNITED STATES,PSYCHIATRY,02,,US,UNIVERSITY OF PENNSYLVANIA,PA,191046205,"PUBLIC HEALTH RELEVANCE: This application proposes to examine the extent to which payers for publicly-funded community mental health employ different incentives to increase the use of evidence- based treatments (EBTs) and the barriers and facilitators to the use of these incentives. The knowledge gained from this proposal will inform future research on the effect of incentives on implementation efforts, with the ultimate goal of encouraging more rapid and effective implementation of EBTs in community mental health systems. ",9163626;,"STEWART, REBECCA E;","HILL, LAUREN D.",11/16/2014,11/15/2017,Academia;Address;Attitude;base;behavioral health;career;Characteristics;Climate;Clinical;Communities;Competitive Bidding;Complex;County;design;Development;Developmental Disabilities;Evidence based practice;Evidence based treatment;experience;Funding;Future;Goals;Health Personnel;Health system;Healthcare;implementation science;Improve Access;improved;Incentives;Individual;Intervention;Interview;Knowledge;Leadership;Learning;Literature;Medicaid;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;National Institute of Mental Health (U.S.);National Research Service Awards;Organizational Culture;Patients;Play;Policies;Positioning Attribute;programs;Provider;public health medicine (field);public health relevance;Public Sector;Publishing;Qualitative Methods;Research;Research Personnel;research study;Research Support;Resources;Role;skills;Strategic Planning;Structure;Surveys;trafficking;Training;Uncertainty;uptake,Investigating the Payer Role in the Implementation of EBP in the Public Sector,103960,ZMH1,Special Emphasis Panel,,A1,1,53432, 8821233,I01,VA,1,N,11/18/2014,10/01/2014,09/30/2015,999,I01BX001736,,RFA-BX-14-001,1I01BX001736-01A2,,Research Projects,2015,Veterans Affairs,,INDIANAPOLIS,UNITED STATES,,07,,US,RLR VA MEDICAL CENTER,IN,462022803,"PUBLIC HEALTH RELEVANCE: Acute kidney injury (AKI) is the most common renal disease requiring hospitalization and is associated with 50% mortality in the ICU. There remains no reliable treatment modality for acute kidney injury that has impacted the dismal survival statistics. Clearly new approaches are urgently required. In the setting of ischemia or hypoxic injury, early alterations in mitochondrial structure impair cellular energetics, activate cell death pathways, increase oxygen free radical generation and may influence renal hemodynamics. Different models of naturally or experimentally induced resistance to ischemic injury may help to identify biochemical, cellular and physiological events underlying the injury process and provide potential targets for therapeutic intervention. The confluence of data suggests that an enhanced regulation of stress related proteins or mitochondria regulated energetics may impart protection in animal models of resistance to AKI The overarching hypothesis of this application is that mitochondrial adaptation to hypoxia entrains mitochondria toward a biosynthetic activity and decreased ATP generative activity. This adaptation has common features in cells primed by ischemia preconditioning or background genetic traits that confer resistance to ischemia. In these studies, we will utilize two different models of resistance to AKI;1) a genetic model of the Brown Norway rat and Brown Norway derived consomic strains of rats, and 2) a model of experimentally induced ischemic preconditioning to determine proteins that confer ischemic protection. Studies in specific objective 1 will test the hypothesis that genetic and experimentally induced models of resistance to I/R (ischemia/reperfusion) have common biochemical properties at the level of the mitochondria. These experiments will utilize a proteomic approach of label- free-quantitative mass spectroscopy to identify biochemical similarities in different models of resistance. Studies in specific objective 2 will investigate the potential protective effect of proteins identified in resistant states. Mitochondrial targeted genes derived from specific aim 1 will be tested an in vitro model of proximal tubule cells and the preservation of mitochondrial function and cellular integrity in response to hypoxia evaluated. Studies in specific objective 3 will evaluate the effec of mitochondrial targeting on the short and long-term response to kidney injury in vivo. Specific objective 4 will study how mitochondria adapt in response to transgene expression, ischemia preconditioning or genetic modifications. These studies will investigate post-ischemic mitochondria respiratory capacity, mitochondrial polarization and the resulting influence on ROS generation and renal hemodynamics. Overall, the proposed studies will help provide an understanding of cytoprotective strategies and identify potential therapeutic targets to manage the severity of AKI. ",1944111;,"BACALLAO, ROBERT L;",,10/01/2014,09/30/2018,3-hydroxy-3-methylglutaryl-coenzyme A;Acute Kidney Failure;Acute Renal Failure with Renal Papillary Necrosis;Address;Admission activity;Aging;Amino Acids;Animal Model;Anions;Biochemical;Biological Preservation;Biology;Brain Hypoxia-Ischemia;Cell Culture Techniques;Cell Death;cell injury;Cell physiology;Cells;Cessation of life;Citrates;Citric Acid Cycle;Communities;Complex;Complication;Consomic Strain;cost;Data;Diabetes Mellitus;Dialysis procedure;Disease;Dose;drug discovery;Electrons;End stage renal failure;Event;Experimental Models;free radical oxygen;Gene Targeting;Generations;Genetic;Genetic Models;Glucose;Glutarates;Health;hemodynamics;Hospitalization;Hospitals;Hypertension;Hypoxia;improved;In Vitro;in vitro Model;in vivo;Injury;injury and repair;Injury to Kidney;Ischemia;Ischemic Preconditioning;isocitrate;Isocitrates;Kidney;Kidney Diseases;Knowledge;Label;Lead;Life;Lipids;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Minor;Mitochondria;Mitochondrial Proteins;Modality;Modeling;Modification;Molecular;Morbidity - disease rate;Mortality Vital Statistics;NADP;Norway;novel strategies;Organism;Oxidative Phosphorylation;Oxygen Consumption;Pathway interactions;Physiological;Population;preconditioning;prevent;Process;Production;Property;protective effect;protein expression;protein profiling;Proteins;Proteomics;Proximal Kidney Tubules;public health relevance;Rattus;Rattus norvegicus;Reaction;Reactive Oxygen Species;Regulation;Renal function;repaired;Reperfusion Injury;Reperfusion Therapy;Research Personnel;research study;Resistance;respiratory;response;Risk;screening;Sentinel;Severities;Signal Pathway;Site;Source;Speed (motion);statistics;Stress;Structure;Succinates;System;Testing;Therapeutic Intervention;therapeutic target;Tissues;trait;transgene expression;United States National Institutes of Health;Yeasts,Endogenous Mitochondria Resistance to Acute Kidney Injury,1736,NEPH,Nephrology,,A2,1,, 8730428,I01,VA,1,N,11/20/2014,10/01/2014,09/30/2015,999,I01BX002310,,RFA-BX-13-001,1I01BX002310-01A1,,Research Projects,2015,Veterans Affairs,,PALO ALTO,UNITED STATES,,,,US,VETERANS ADMIN PALO ALTO HEALTH CARE SYS,CA,943041207,"PUBLIC HEALTH RELEVANCE: Cardiovascular disease is the leading cause of death in Americans and in the Veteran population. In particular, coronary heart disease (CHD) is characterized by narrowing of the blood vessels that supply blood flow to the heart, leading to heart attack and ultimately heart failure. Understanding how to engineer biological replacement cardiac tissue is important for developing effective treatments for CHD in our Veterans. We believe that using scaffolds that guide the organization of cardiac cells will help to scale-up the size of engineered tissues, due to the ability of the scaffolds to maintain cell survival and promote cardiac health. Importantly, we will examine the biochemical processes that help improve cardiac cell survival and function within the cardiac patches. Together, these studies offer great hope to the development of therapies that for treating Veterans with CHD. ",9408579;,"HUANG, NGAN F.;",,10/01/2014,09/30/2018,Action Potentials;American;angiogenesis;Animals;Autologous;Automobile Driving;base;Biochemical Process;Biological;Biological Assay;bioluminescence imaging;Blood flow;Blood Vessels;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Communication;Cell Culture Techniques;Cell physiology;Cell Survival;Cell Therapy;Cell Transplants;Cells;Cellular Morphology;Cellular Structures;Chemicals;Cicatrix;Clinical;Clinical Trials;Coculture Techniques;Collagen;Coronary artery;Coronary heart disease;Coupling;Cues;Development;effective therapy;Endothelial Cells;Engineering;Epicardium;Extracellular Matrix;Foundations;functional improvement;Gap Junctions;Generations;Genetic;Goals;Health;Heart;Heart failure;Human;Implant;improved;induced pluripotent stem cell;Infarction;Injection of therapeutic agent;insight;Ischemia;Knowledge;Ligation;loss of function;Measurement;Measures;Mediating;Methods;Modeling;Molecular;Monitor;Morphology;Mortality Vital Statistics;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial tissue;Myocardium;nanopattern;Natural regeneration;Nitric Oxide;Phenotype;Physiological;Population;Production;public health relevance;Pump;Rattus;release factor;repaired;Research;Role;scaffold;scale up;Signal Transduction;Signaling Molecule;Source;Structure;Therapeutic;Therapeutic Effect;therapy development;Thick;Time;Tissue Engineering;tissue repair;Tissues;tool;Transplantation;Ventricular Ejection Fractions;Veterans,Vascularized Cardiac Patch with Physiological Orientation for Myocardial Repair,2310,SURG,Surgery,,A1,1,, 8733353,I01,VA,1,N,11/17/2014,10/01/2014,09/30/2015,999,I01CX000982,,RFA-CX-13-001,1I01CX000982-01A1,,Research Projects,2015,Veterans Affairs,,NASHVILLE,UNITED STATES,,05,,US,VETERANS HEALTH ADMINISTRATION,TN,372122637,"PUBLIC HEALTH RELEVANCE: Chronic kidney disease (CKD) is a major public health problem worldwide. Obesity, hypertension and diabetes are major risk factors for developing CKD. CKD patients suffer from premature death because of cardiovascular disease. Obesity affects more than one-third of the US population, 35.5% of the VA population and about 50% of the CKD population. In this proposal, we focus on the consequences of the coexistence of obesity and CKD and their relative and combined contribution to the development of insulin resistance and cardiovascular disease in people with CKD. The first part of this proposal will study obesity-related hormones that accumulate when your kidneys are not working and what they can tell us about the metabolic problems seen in these circumstances including insulin resistance. The second part of the proposal wills study if certain medications that are known to improve metabolic disease in obese patients with normal kidney function will reverse these metabolic derangements in CKD, and reduce cardiovascular disease and death. ",8604104;,"HUNG, ADRIANA;",,10/01/2014,09/30/2018,adipokines;adiponectin;Adipose tissue;Affect;Anti-inflammatory;Anti-Inflammatory Agents;Antiatherogenic;Atherosclerosis;Biological Markers;Blood Vessels;burden of illness;Cardiovascular Diseases;Caring;Cessation of life;Chronic;Chronic Kidney Failure;Clinical;clinical practice;Data;Development;Diabetes Mellitus;Elements;End stage renal failure;Endocrine Glands;endothelial dysfunction;Epidemic;Euglycemic Clamping;Event;Fatty acid glycerol esters;Functional disorder;General Population;Generations;Glucose Clamp;glucose disposal;Gold;Growth;Health;health administration;Healthcare Systems;High Prevalence;high risk;Hormones;Hyperinsulinism;Hypertension;improved;indexing;Inflammation;Insulin;Insulin Resistance;Intervention;Kidney;kidney vascular structure;Knowledge;Lead;Leptin;Measures;Medicare;Metabolic;Metabolic acidosis;Metabolic Diseases;Metabolic Marker;Metabolic syndrome;Metformin;Mission;moderate obesity;Monitor;Morbidity - disease rate;Mortality Vital Statistics;Names;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;Output;Oxidative Stress;Pathogenesis;Patients;Pharmaceutical Preparations;Placebos;Play;Population;premature;Prevalence;prevent;primary outcome;Production;public health medicine (field);public health relevance;Relative (related person);Renal function;Research;Risk;Risk Factors;Role;Testing;Time;tool;Veterans;Work,Dysmetabolism of Chronic Kidney Disease and Vascular Health,982,ENDA,Endocriniology A,,A1,1,, 8397525,I01,VA,1,N,11/20/2014,04/01/2013,03/31/2014,999,I01RX000601,,RFA-RX-11-013,1I01RX000601-01A2,,Research Projects,2015,Veterans Affairs,,SAN FRANCISCO,UNITED STATES,,12,,US,VETERANS AFFAIRS MED CTR SAN FRANCISCO,CA,941211545,"Epidermal dysfunction and abnormal keratinocyte activities in aged skin often lead to severe clinical consequences such as delayed wound healing, inflammation and morbidity in elderly Veterans patients. At the present time, the cellular and molecular mechanisms causing epidermal dysfunction associated with skin aging are not well understood. However, studies now reveal abnormal hyaluronan (HA) metabolism may be involved in the changes associated with keratinocyte activities, permeability barrier homeostasis and wound healing during skin aging processes and disease progression. The new knowledge obtained from our proposed studies will allow us to delineate specific HA (small vs. large)-mediated signaling events (through the CD44 receptor) and subsequent keratinocyte activities, as well as to provide important information that will offer improved therapeutic options for Veterans patients suffering aging-related skin diseases such as chronic non-healing wounds, epidermal thinning (atrophy), barrier dysfunction, xerosis/xerotic eczema, and inflammation.",8241170;,"BOURGUIGNON, LILLY YW;",,04/01/2013,03/31/2017,Abnormal Keratinocyte;Accounting;Address;adducin;Affect;age related;aged;Aging;Aging-Related Process;alveolar lamellar body;Atrophic;base;Biochemical;Caring;CD44 Antigens;CD44 gene;Cell Survival;Chronic;Clinical;cytokine;Cytoskeleton;Defect;Dermal;Development;Disease Progression;Eczema;Elderly;Epidermis;Event;Extracellular Matrix;Fibroblasts;Functional disorder;Goals;Growth Factor;Homeostasis;Human;Hyaluronan;Impaired wound healing;improved;Inflammation;Inflammatory;keratinocyte;Knowledge;Lead;Lipids;Longevity;Mediating;MEKs;Metabolism;migration;Mission;mitogen-activated protein kinase p38;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;myosin phosphatase;novel;p65;Pathway interactions;Patient Care;Patients;Permeability;Phenotype;Physiological;Process;Production;programs;Proteins;public health relevance;receptor;Rehabilitation therapy;Research;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Skin;Skin Aging;skin disorder;Techniques;Testing;Therapeutic;Time;Topical application;Transcription Factor AP-1;Transcriptional Activation;Veterans;Wound Healing,Selective Hyaluronan Treatment to Overcome Age-related Epidermal Dysfunction,601,RRD6,Aging &Neurodegenerative Disease ,,A2,1,, 8396281,I01,VA,1,N,11/20/2014,03/01/2013,02/28/2014,999,I01RX000652,,RFA-RX-11-013,1I01RX000652-01A2,,Research Projects,2015,Veterans Affairs,,PITTSBURGH,UNITED STATES,,14,,US,VETERANS HEALTH ADMINISTRATION,PA,152061206,Refractory wound is a major clinical problem in diabetic patients that often leads to amputations. This study explores a novel microRNA molecule mir-27b and its effect on wound angiogenesis and repair in type 2 diabetes. The expectant outcome from this study may provide a mechanistic basis to facilitate the translation of this important new knowledge into clinical arena.,1858842;,"CHEN, ALEX F;",,03/01/2013,02/28/2017,Adaptor Signaling Protein;Affect;Amputation;angiogenesis;Angiogenesis Inhibitors;Angiogenic Proteins;Attenuated;Autologous;base;Base Pairing;Binding (Molecular Function);Blood flow;Cell physiology;Cell Therapy;Clinical;Clinical Protocols;Complication;Data;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Diabetic wound;diabetic wound healing;Disease;Endothelial Cells;fascinate;Foot Ulcer;Functional RNA;Funding;Gene Expression;Generations;Healed;healing;Hyperglycemia;improved;in vivo;Knowledge;Laboratories;Lead;Manganese Superoxide Dismutase;Mediating;MicroRNAs;Mitochondria;Modification;mouse ShcA protein;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Outcome Study;Oxidative Stress;p66(ShcA) protein;Patients;Play;pre-clinical;Proteins;public health relevance;Publishing;Reactive Oxygen Species;Refractory;Regulation;Regulator Genes;repaired;Reporting;response;restoration;Role;Stem cells;success;Testing;Therapeutic;thrombospondin 2;Time;Translating;Translations;Work;wound;Wound Healing,MicroRNA Regulation of Endothelial Progenitor Cell Function and Wound Healing,652,RRD0,Translational Rehab (Basic),,A2,1,, 8396812,I01,VA,1,N,11/20/2014,01/01/2013,12/31/2013,999,I01RX000880,,RFA-RX-11-016,1I01RX000880-01A1,,Research Projects,2015,Veterans Affairs,,CHICAGO,UNITED STATES,,07,,US,JESSE BROWN VA MEDICAL CENTER,IL,606123728,"Approximately, ~28,000 returning Service Members sustain TBI each year. Service Members who already have sustained TBI may again be deployed to the battlefield due to the uncertainty of TBI screening instrument (TBISI) and mixed/overlapping symptoms of TBI/PTSD. Sustaining second concussion before the previous one is resolved, puts these Service Members at a high risk of developing long-term neurodegeneration. Considerable cases of TBI may go undiagnosed and untreated until much later after actual injury. Current therapeutic strategies do help TBI Veterans to some degree, but there remains a compelling need for investigating therapeutic efficacy of candidate drugs as a late stage treatment to manage heterogenic chronic disability from TBI, that most Veterans are currently facing. This investigation is to evaluate post-acute effects of Simvastatin in a controlled cortical impact (CCI) model of TBI that will address an unmet need for treating Veterans who suffer chronic disability from TBI, and thus will address highest VA research priority.",3155624;,"CHAUHAN, NEELIMA B.;",,01/01/2013,12/31/2015,Acute;Address;Afghanistan;Aftercare;Anatomy;angiogenesis;Anti-inflammatory;Anti-Inflammatory Agents;Apoptosis;Appearance;astrogliosis;Axon;Behavioral;Biochemical;Brain Concussion;Brain Injuries;Brain-Derived Neurotrophic Factor;care seeking;Caring;Cholesterol;Chronic;Coenzyme A;Cognition;Cognitive;Cognitive deficits;combat;Complex;controlled cortical impact;Dendrites;disability;drug candidate;Epidemic;Etiology;Event;Exposure to;Functional disorder;functional outcomes;Growth;Heterogeneity;high risk;Hippocampus (Brain);improved;inhibitor/antagonist;Injury;instrument;interest;Investigation;Iraq;Learning;Life;member;Memory;Modeling;Molecular;Mono-S;mouse model;Multiple Trauma;Nature;Nerve Degeneration;Nerve Regeneration;neurogenesis;neuroinflammation;Neurons;Neuroprotective Agents;Neurotransmitters;neurotrophic factor;open wound;Orthopedics;Outcome;Oxidoreductase;Patients;Physiological;pleiotropism;Post-Traumatic Stress Disorders;Property;Provider;public health relevance;Rattus;Reporting;Research Priority;screening;Screening procedure;Services;Severities;Signal Pathway;Simvastatin;Sleeplessness;Soldier;Staging;Symptoms;Synapses;Testing;Therapeutic;therapeutic target;Time;Traumatic Brain Injury;treatment effect;Treatment Efficacy;Uncertainty;Up-Regulation (Physiology);Veterans;War,Neuroregenerative Effects of Simvastatin in TBI,880,RRD1,Brain Injury: TBI &Stroke ,,A1,1,, 8398367,I21,VA,1,N,11/20/2014,04/01/2013,03/31/2014,999,I21RX000353,,RFA-RX-11-014,1I21RX000353-01A2,,Research Centers,2015,Veterans Affairs,,OMAHA,UNITED STATES,,02,,US,OMAHA VA MEDICAL CENTER,NE,681051873,"Persons with a long history of chronic and excessive alcohol consumption (alcohol abusers) experience complications often leading to failure of fracture healing. Experimental studies show that alcohol causes cellular abnormalities in the early stage of fracture healing leading to this failure. In the proposed project we will evaluate the efficacy of the antioxidant n-acetylcysteine (NAC) to prevent the failure of fracture healing in alcohol abusers. In a recent study it was found that inhibition of new bone formation in closed femoral fractures created in rats following binge alcohol exposure could be prevented by administration of NAC during 2 weeks after fracture.The efficacy of NAC for clinical treatment of a large variety of conditions has been documented in a large number of clinical studies during the past two decades. It is well tolerated, has well-defined mechanisms of action and is acknowledged as a safe antidote for cysteine/glutathione deficiency .",2058383;,"CHAKKALAKAL, DENNIS ABRAHAM;",,04/01/2013,03/31/2015,20 year old;Abstinence;Acetylcysteine;Affect;Age;Age of Onset;Age-Months;alcohol abstinence;Alcohol abuse;Alcohol consumption;alcohol exposure;Alcoholism;Alcohols;Animal Model;Animals;Antidotes;Antioxidants;base;beta catenin;Binding (Molecular Function);binge drinking;bone healing;Bone Regeneration;Boxing;Cartilage;Cell physiology;Cells;Chronic;chronic alcohol ingestion;Cicatrix;Clinical;Clinical Research;Clinical Treatment;Cysteine;cytokine;Data;design;Diet;dietary antioxidant;dietary restriction;DNA Repair;Enhancers;Enzymes;Equilibrium;Ethanol;Ethanol Metabolism;experience;Experimental Models;Failure (biologic function);feeding;Femoral Fractures;Femur;fibrogenesis;Fracture;Fracture Healing;Free Radical Scavenging;Genetic Transcription;Glutathione;Healed;healing;Heavy Drinking;Host Defense;Human;Incidence;Infection;Inflammatory;Inflammatory Response;Injection of therapeutic agent;Injury;innovation;Intake;intramembranous bone formation;Knowledge;Lymphoid;Mature Bone;Mechanics;Mediating;Methods;Modeling;Molecular;Natural regeneration;non-compliance;nutrition;Operative Surgical Procedures;Orthopedics;Osteoblasts;Osteogenesis;Osteotomy;Outcome;Oxidants;Oxidative Stress;pathogen;Pathway interactions;Patients;Persons;Phase;Population;prevent;Prevention;problem drinker;Protocols documentation;public health relevance;Rattus;Reactive Oxygen Species;Recording of previous events;Recovery;Reducing diet;Research Design;research study;response;restoration;sample fixation;Signal Transduction;Site;skeletal;Staging;Subcutaneous Injections;TCF Transcription Factor;Testing;Time;tissue repair;Tissues;Translations;Veterans,Prevention of Fracture Healing Failure in Alcohol Abusers,353,RRD0,Translational Rehab (Basic),,A2,1,, 8396506,I21,VA,1,N,11/20/2014,04/01/2013,03/31/2014,999,I21RX000994,,RFA-RX-11-014,1I21RX000994-01,,Research Centers,2015,Veterans Affairs,,DECATUR,UNITED STATES,,04,,US,VETERANS HEALTH ADMINISTRATION,GA,300334004," Of nearly 22 million US veterans, 38.5% are over 65. With an additional 24.9% of veterans between the ages of 55 and 64, the number of veterans over age 65 will increase dramatically in the next decade. Word retrieval in older adults declines from the late 50's through the 90's in independently living, community dwelling adults. Our research indicates that both speed and accuracy of word retrieval are affected in older, community-dwelling adults compared to younger adults. Poor word retrieval affects the ability to communicate. Reduced communication effectiveness can impact quality of life and put older adults at risk for inaccurate diagnosis and poor health outcomes. Our study will determine whether greater right frontal activity in older compared to younger adults helps or hurts word finding. Eventually, this information can be used to develop interventions for poor word finding in older adults at risk for poor communication, impacting quality of life and health outcomes for millions of veterans. ",1896511;,"CROSSON, BRUCE A;",,04/01/2013,03/31/2015,16 year old;Adult;Affect;Age;Age-Years;Aging;aging brain;Aphasia;Area;base;Brain;Brain Injuries;Broca Aphasia;Broca's area;clinically relevant;cognitive system;Collaborations;Communication;Communities;community living;Data;Data Storage and Retrieval;Deterioration;Diagnosis;Effectiveness;Elderly;Financial compensation;Frequencies (time pattern);frontal lobe;Functional Magnetic Resonance Imaging;Generations;Goals;Hand;Health;Homologous Gene;improved;Intervention;Knowledge;Laboratories;Language;Lead;Left;Measures;Methods;Middle Inferior Frontal Convolution;Modeling;Motor;Motor Cortex;Movement;Names;Nature;Outcome;Patients;Performance;Production;public health relevance;Quality of life;Reaction Time;Relative (related person);repetitive transcranial magnetic stimulation;Research;response;Retrieval;Risk;Role;Short-Term Memory;Speed (motion);stroke;Study Section;Survivors;syntax;System;Testing;tool;Veterans;Work;young adult,Right Frontal Activity in Older Adults: Does It Help or Hurt Word Retrieval?,994,RRD3,Sensory Systems/Communication ,,,1,, 8398875,I21,VA,1,N,11/20/2014,04/01/2013,03/31/2014,999,I21RX001084,,RFA-RX-11-014,1I21RX001084-01,,Research Centers,2015,Veterans Affairs,,IOWA CITY,UNITED STATES,,02,,US,IOWA CITY VA MEDICAL CENTER,IA,522462209,"Diabetic complications are an important source of blindness and mortality among veterans. Their occurrence is unpredictable because of the highly variable effect of factors such as weight, diet and exercise. Improved prediction of diabetes complications has the potential to improve the care for veterans with diabetes, especially if this can be done without any extra effort for the veterans or their caretakers. All veterans with diabetes in VHA are required to undergo annual retinal photography to screen for current diabetic retinopathy. We have recently developed an automated, precise, fast, novel tool for measuring retinal vessels in these images. Manual measurement of retinal vessels has shown that these can predict future -not current- development of hypertension and also diabetic retinopathy. If we can confirm that our tool can flag those veterans at increased risk for developing these diabetes complications, this will allow earlier intervention and prevention. Because the tool only uses the images that are being taken anyway, there is no extra effort for either the veteran or VA staff.",8032534;,"ABRAMOFF, MICHAEL DAVID;",,04/01/2013,03/31/2015,Biological Markers;Blindness;Blood Pressure;Caliber;Caring;Clinical;Color;Complications of Diabetes Mellitus;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Diagnosis;diet and exercise;Early Intervention;Early treatment;Fundus;Future;Goals;high risk;Hypertension;Image;Image Analysis;improved;International;macular edema;Manuals;Measurement;Measures;Methods;Mortality Vital Statistics;novel;Patients;Photography;Pilot Projects;Population;Population Study;Prevention;programs;public health relevance;retina blood vessel structure;Retinal;Retinal Diseases;Risk;Risk Factors;screening;Screening procedure;Severities;Source;Time;tool;Venous;Veterans;Weight;Width,Retinal vessel measurements as clinically useful predictors in veterans,1084,RRD3,Sensory Systems/Communication ,,,1,, 8803666,K01,HL,1,N,11/15/2014,11/15/2014,10/31/2015,837,K01HL125504,SCHOOLS OF MEDICINE,RFA-HL-13-019,1K01HL125504-01,NHLBI:149778\,Other Research Related,2015,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HONOLULU,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,,US,UNIVERSITY OF HAWAII AT MANOA,HI,968222234,"HIV-positive individuals harbor monocytes that are hyper-responsive to inflammatory stimuli, which may contribute to their heightened risk for cardiovascular disease (CVD). Epigenomic analyses integrated with clinical and immunological indicators of CVD risk may reveal gene loci underlying this hyper-responsive phenotype. These data may enable improved risk stratification strategies for CVD.",7674310;,"MAUNAKEA, ALIKA K;","MEADOWS, TAWANNA ",11/15/2014,10/31/2018,abstracting;Address;Adult;Age;base;Bioinformatics;Biological Assay;Biological Markers;bisulfite;Blood;Blood specimen;Cardiovascular Diseases;cardiovascular disorder risk;CD14 gene;cell type;Clinical;Cohort Studies;Collaborations;Coronary heart disease;Data;Databases;Development;Dialysis patients;Disease;DNA;DNA Methylation;epigenetic marker;Epigenetic Process;epigenomics;Exhibits;FCGR3B gene;Future;Gene Expression;Gene Expression Profile;Genes;genome-wide;Hawaii;High Prevalence;high risk;HIV;HIV Infections;HIV Seropositivity;Human;Hyperlipidemia;IL6 gene;IL8 gene;immune activation;improved;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Response;Insulin Resistance;Interleukin-1;Interleukin-6;Link;Lipopolysaccharides;macrophage;Massive Parallel Sequencing;Measures;Mediating;Messenger RNA;Methods;methylome;Modification;Molecular Profiling;monocyte;Mortality Vital Statistics;mRNA Precursor;Myelogenous;novel;Organism;oxidized low density lipoprotein;Pathology;Patients;Pattern;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;Promoter Regions (Genetics);Protein Isoforms;Publishing;Research;response;Risk;Risk Factors;RNA;RNA Splicing;Role;Smoking;Stimulus;Stratification;Technology;Testing;transcriptome sequencing;transcriptomics;trend;Variant,Identifying epigenetic biomarkers of cardiovascular disease risk in humans,125504,ZHL1,Special Emphasis Panel,,,1,149778, 8822064,K99,HL,1,N,11/17/2014,11/17/2014,10/31/2015,837,K99HL122454,SCHOOLS OF MEDICINE,PA-14-042,1K99HL122454-01A1,NHLBI:86860\,Other Research Related,2015,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CINCINNATI,UNITED STATES,PSYCHIATRY,01,,US,UNIVERSITY OF CINCINNATI,OH,452210001,"Project Narrative Heart disease is the leading cause of death in the United States, and is frequently initiated or exacerbated by stress. In fact, heightened reactions to acute psychological stress and chronic stress exposure are both associated with increased cardiovascular mortality. The prefrontal cortex is a brain region implicated in stress appraisal, regulating behavioral and physiological responses to stress. The goal of this proposal is to determine how the prefrontal cortex regulates cardiovascular stress pathology. Specific aims will test the overarching hypothesis that the prefrontal cortex attenuates the acute stress hyper-reactivity and chronic stress-induced sympathovagal imbalance that promote cardiovascular disease.",10592948;,"MYERS, BRENT PHILIP;","WANG, WAYNE C.",11/17/2014,10/31/2016,"Acute;acute stress;Address;Adrenal Glands;Advisory Committees;Affect;Area;Arrhythmia;Attenuated;Automobile Driving;awake;Award;base;Behavioral;biological adaptation to stress;Biological Assay;Blood Pressure;Blood Vessels;Brain region;Cardiac;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular Physiology;Cardiovascular system;career;career development;Cause of Death;Chronic;Chronic stress;Clinical Research;Code;Critiques;Data;Data Aggregation;Development;Echocardiography;Educational workshop;Endocrine;Event;Exposure to;Functional disorder;Funding Mechanisms;Generations;Genes;Glucocorticoids;Glutamate Receptor;Glutamate Transporter;Glutamates;Goals;Grant;Health;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Heart Rate;Histology;Homeostasis;Hormones;Hypertension;hypertensive heart disease;Hypothalamic structure;Incidence;Inflammation Mediators;inflammatory marker;Ion Channel;K-Series Research Career Programs;Kidney;lentiviral-mediated;Link;Lipids;Maps;Measurement;Measures;Mediating;Mediator of activation protein;meetings;Mentors;Morbidity - disease rate;Mortality Vital Statistics;Nerve;neurobiological mechanism;Neurobiology;neurochemistry;neuromechanism;Neurons;Neurosciences;novel;Optics;optogenetics;Output;Pathology;Pathway interactions;Pharmacology;Phase;Physiological;Plasma;Positioning Attribute;Posterior Hypothalamus;Predisposing Factor;Prefrontal Cortex;pressure;presynaptic;prevent;programs;Promotor (Genetics);Psychological Stress;Psychosocial Stress;Rattus;Reaction;Regimen;Regulation;Research;research study;response;Risk Factors;Rodent;Role;Signal Transduction;Site;Small Interfering RNA;Stress;Stress Disorders, Traumatic, Acute;stress related disorder;Structure;Sympathetic Nervous System;Tachycardia;Testing;Therapeutic Intervention;Time;Training;United States;vector;Viral Packaging;Viral Vector;Writing",Prefrontal Cortical Circuitry Attenuates Cardiovascular Stress Reactivity,122454,ZHL1,Special Emphasis Panel,,A1,1,86860, 8825112,R01,ES,1,N,11/17/2014,11/17/2014,10/31/2015,113,R01ES023839,SCHOOLS OF PUBLIC HEALTH,PA-13-302,1R01ES023839-01A1,NIEHS:348921\,Research Projects,2015,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,ATLANTA,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,05,,US,EMORY UNIVERSITY,GA,303224250,"PUBLIC HEALTH RELEVANCE: Parkinson's disease (PD) afflicts over one millions U.S. citizens and is caused by a combination of environmental and genetic factors. This proposal will examine how persistent environmental chemicals disrupt key processes of dopamine function, which may contribute to the development of PD. The results of these studies may provide a foundation for new approaches to prevent or treat the disease. ",1862308;,"MILLER, GARY W;","LAWLER, CINDY P.",11/17/2014,10/31/2019,Address;aged;Aldehydes;alpha synuclein;Animals;Bacterial Artificial Chromosomes;base;Behavior;Brain;Corpus striatum structure;Data;Development;Disease;Dopamine;dopamine system;dopaminergic neuron;Electrochemistry;environmental chemical;Foundations;Functional disorder;Gene Mutation;Genetic;genetic manipulation;Glycoproteins;Gold;Histology;Human;improved functioning;in vivo;Individual;innovation;Knock-out;Laboratories;Literature;Measures;Mediating;Microdialysis;Modeling;Motor;motor deficit;Mus;Nerve Degeneration;neurochemistry;Neurons;neuropathology;neuroprotection;neurotoxicity;Neurotoxins;Neurotransmitters;novel;novel strategies;novel therapeutic intervention;optogenetics;overexpression;Parkinson Disease;pars compacta;Pathogenesis;Pathology;Play;Polychlorinated Biphenyls;prevent;Process;public health relevance;Resistance;Rotenone;Scanning;Signal Transduction;Slice;standard care;Substantia nigra structure;Synaptic Vesicles;System;Techniques;Testing;theories;Toxic effect;Transgenic Mice;uptake;Vesicle,Vesicular modulation of dopamine neuron toxicity,23839,NAL,Neurotoxicology and Alcohol Study Section,,A1,1,348921, 8817972,R01,HL,1,N,11/17/2014,11/17/2014,10/31/2015,837,R01HL119441,,PA-13-302,1R01HL119441-01A1,NHLBI:395958\,Research Projects,2015,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DENVER,UNITED STATES,,01,,US,NATIONAL JEWISH HEALTH,CO,802062761,"PUBLIC HEALTH RELEVANCE: Asthma is the most common chronic disease among youth, and despite medical advances in treatment and prevention efforts, asthma prevalence continues to rise. Thus there is a need to identify modifiable health behaviors, including sleep duration, that may reduce asthma exacerbations and improve asthma control. This study will use an established sleep manipulation protocol to examine the impact of deficient vs. healthy sleep duration on lung function and functional outcomes in adolescents with asthma, a population at-risk for chronic partial sleep restriction. ",8149037;,"MELTZER, LISA J;","LAPOSKY, AARON D.",11/17/2014,10/31/2018,"Accounting;actigraphy;Address;Adolescent;Affect;Age;Asthma;base;Beds;Behavior Therapy;Biological;Biological Markers;Bronchoconstriction;Childhood;Childhood Asthma;Chronic;Chronic Disease;Circadian Rhythms;clinical care;Clinical Management;cost;cytokine;Data;design;Developed Countries;Development;diaries;Disease;Disease Outcome;Electronics;Enrollment;Exhalation;experience;Financial cost;Frequencies (time pattern);functional outcomes;Funding;Goals;Health;Health behavior;health related quality of life;Healthy People 2020;Hour;Human;Immunology;improved;Inflammation;Inflammatory;Interleukin-1;Interleukin-6;Intervention;Intervention Studies;Link;Measures;Medical;Morbidity - disease rate;multidisciplinary;National Heart, Lung, and Blood Institute;Nitric Oxide;novel;Outcome;Outcome Measure;Pathway interactions;Patient Self-Report;Peak Expiratory Flow;Peak Expiratory Flow Rate;Pharmaceutical Preparations;Pilot Projects;Populations at Risk;Practice Guidelines;Prevalence;Prevention;Productivity;Protocols documentation;public health relevance;pulmonary function;Randomized;Reporting;Research;Research Personnel;Respiratory physiology;Rest;Role;Sampling;Schools;Serum;Severities;Sleep;Sleep Deprivation;Societies;Spirometry;Symptoms;Testing;Time;TNF gene;United States National Institutes of Health;Vulnerable Populations;Youth","Deficient Sleep Lung Function, and Functional Outcomes in Adolescents with Asthma",119441,MESH,"Biobehavioral Mechanisms of Emotion, Stress and Health Study Section",,A1,1,395958, 8816671,R01,HL,1,N,11/17/2014,11/18/2014,10/31/2015,837,R01HL122560,SCHOOLS OF MEDICINE,PA-13-302,1R01HL122560-01A1,NHLBI:416250\,Research Projects,2015,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,,US,YALE UNIVERSITY,CT,065103209,"PUBLIC HEALTH RELEVANCE: Some arrhythmias are due to scar in the heart chambers, which interacts with the electrical system of the heart. MRI has the possibility of detecting the development of this scar, due to increased stretch and linking it to scar. Development of these capabilities will improve patient care by improving our understanding about why scar-- which causes arrhythmia-develops. ",7936584;,"PETERS, DANA C;","BOINEAU, ROBIN ",11/18/2014,10/31/2018,Acute myocardial infarction;Age;Animal Model;Animals;Arrhythmia;Atrial Fibrillation;base;Blood;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cicatrix;Collagen;Congestive;Congestive Heart Failure;design;Detection;Development;Diffuse;Disease;Early treatment;Etiology;extracellular;Family suidae;Fatty acid glycerol esters;Fibrosis;Gadolinium;gadolinium oxide;Geometry;Goals;Health Benefit;Heart;Heart Atrium;Heart Diseases;Heart Transplantation;Histology;Image;improved;in vivo;Infarction;Inflammation;innovation;interstitial;Intervention;Ischemia;Lead;Link;Liquid substance;Location;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Maps;Measurement;Measures;Mediating;Methodology;Methods;Metric;Mitral Valve;Mitral Valve Insufficiency;Modeling;Morphologic artifacts;Mortality Vital Statistics;Myocardial;Myocardial Infarction;novel;novel strategies;Patient Care;Patient Selection;Patients;Pharmaceutical Preparations;Physiologic pulse;Preparation;pressure;prevent;Prevention;Process;Prophylactic treatment;public health relevance;Refractory;Relative Risks;Resolution;response;Risk;Risk Factors;Shapes;Stress;Stretching;stroke;System;Techniques;Testing;therapeutic target;Time;Transplant Recipients;Validation;Ventricular Dysfunction;Work,Detection of Atrial Remodeling by MRI: Validation and Emerging Significance,122560,ZRG1,Special Emphasis Panel,,A1,1,416250, 8818759,R01,HL,1,N,11/19/2014,11/19/2014,10/31/2015,837,R01HL122822,SCHOOLS OF MEDICINE,PA-13-302,1R01HL122822-01A1,NHLBI:544492\,Research Projects,2015,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,,US,YALE UNIVERSITY,CT,065103209,"PUBLIC HEALTH RELEVANCE: Hyperlipidemia is a major risk factor for coronary artery disease. We recently identified a mutation in a gene called LRP6, which causes early blockages of heart arteries, and hyperlipidemia. The current proposal studies the mechanism of hyperlipidemia in a mouse model of this mutation in order to identify novel drug targets. ",6798779;,"MANI, ARYA;","LIU, LIJUAN ",11/19/2014,10/31/2018,Accounting;Address;Animal Model;Apolipoproteins B;Atherosclerosis;biological systems;Cardiovascular Diseases;Cells;Cholesterol;Clinical Research;Combined Modality Therapy;Coronary Arteriosclerosis;Coronary artery;Crossbreeding;Development;Diabetes Mellitus;Diet;Disease;Disease Pathway;Drug Targeting;early onset;Exhibits;Familial Combined Hyperlipidemia;Fatty Liver;Functional disorder;General Population;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Hepatic;Hepatocyte;Heterozygote;Homeostasis;Homozygote;Human;human disease;human FRAP1 protein;Hyperlipidemia;IGF1 gene;IGF1R gene;Individual;Insulin;insulin signaling;Investigation;Knock-out;Knockout Mice;LDL Cholesterol Lipoproteins;Link;lipid biosynthesis;lipid disorder;Lipids;Lipoproteins;Liver;Liver diseases;loss of function mutation;low density lipoprotein triglyceride;Low-Density Lipoproteins;Mediator of activation protein;Metabolic;Metabolic syndrome;Modeling;Molecular;mouse model;Mus;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Online Mendelian Inheritance In Man;overexpression;Pathway interactions;Phenotype;Phosphorylation;Plasma;Point Mutation;prevent;Proteins;Proto-Oncogene Proteins c-akt;public health relevance;Regulation;Risk;Risk Factors;Role;Science;Signal Transduction;TCF7L2 gene;Therapeutic Agents;therapeutic development;transcription factor;Triglycerides;Variant;Very low density lipoprotein;Wnt proteins,Hepatic Wnt/LRP6 Regulation of Plasma Lipids,122822,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,A1,1,544492, 8813086,R01,HL,1,N,11/15/2014,11/15/2014,10/31/2015,837,R01HL123160,,PAR-13-137,1R01HL123160-01A1,NHLBI:746311\,Research Projects,2015,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ROCHESTER,UNITED STATES,,01,,US,MAYO CLINIC ROCHESTER,MN,559050001,"PUBLIC HEALTH RELEVANCE: Adequate strategies to attenuate remodeling and loss of microvessels distal to an arterial obstruction are yet to be identified and remain in dire need. Non-invasive low-energy extracorporeal shock wave treatment (SWT) is a novel experimental strategy, which can promote neovascularization, suppresses inflammation, and improves function, but is yet to be attempted in microvascular disease associated with renovascular hypertension. The proposed studies may establish this novel, clinically feasible therapeutic strategy and will likely contribute significantly towards management of patients with this disease. ",1915713;,"LERMAN, LILACH O;","OH, YOUNGSUK ",11/15/2014,10/31/2018,Adoption;aging population;Angioplasty;artery occlusion;Attenuated;Autologous;Basic Science;Biochemical;Biological;Biological Sciences;Biomedical Engineering;Blood Circulation;Bone Regeneration;cardiovascular risk factor;Cardiovascular system;Cell membrane;Chronic;Clinical;Clinical Medicine;Clinical Sciences;Collaborations;Data;density;detector;Development;Disease;Disease Management;Distal;Failure (biologic function);Family suidae;Focal Adhesion Kinase 1;Functional disorder;functional restoration;hemodynamics;Human;Hypertension;Imaging Techniques;improved;improved functioning;In Situ;Inflammation;injured;Injury;Injury to Kidney;innovation;Integrins;Interdisciplinary Study;Intervention;Ischemia;Kidney;kidney vascular structure;Limb structure;Link;Magnetic Resonance Imaging;Mechanics;Mechanoreceptors;Mediating;Medicine;Membrane;Metabolic syndrome;Microcirculation;Microvascular Dysfunction;Modeling;multidisciplinary;Myocardial Ischemia;Natural regeneration;neovascularization;novel;novel strategies;novel therapeutics;Outcome;Oxidative Stress;Pathogenesis;Patients;Peripheral Vascular Diseases;Permeability;physical science;Physiology;Process;public health relevance;receptor;Recovery;renal artery;Renal function;Renovascular Hypertension;Research;Research Project Grants;response;Rodent Model;Shock;Signal Transduction;Site;Stem cells;Stenosis;Stress;Structure;Techniques;Tendon structure;Testing;Therapeutic;therapeutic target;tool;Translating;Translational Research;translational study;Tubular formation;Ultrasonography;Vascular Diseases;Western World;Work,Ultrasound shockwave therapy for post-stenotic microvascular remodeling,123160,ZRG1,Special Emphasis Panel,,A1,1,746311, 8801085,R01,HL,1,N,11/21/2014,11/21/2014,10/31/2015,837,R01HL125649,SCHOOLS OF MEDICINE,PA-13-302,1R01HL125649-01,NHLBI:400000\,Research Projects,2015,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,PATHOLOGY,13,,US,COLUMBIA UNIVERSITY HEALTH SCIENCES,NY,100323702,"PUBLIC HEALTH RELEVANCE: Diabetes and the metabolic syndrome are major risk factors for cardiovascular disease, which is the leading cause of death in the United States. Impairments in HDL functions such as reverse cholesterol transport or vasoprotection may link these disorders, but the mechanisms remain unclear. Identifying the key players in the relationships between insulin resistance, reverse cholesterol transport, and HDL function will improve our ability to treat patients more effectively. ",10098932;,"HAEUSLER, REBECCA ANNE;","LIU, LIJUAN ",11/21/2014,10/31/2019,Affect;Apolipoproteins;Arteries;atheroprotective;Atherosclerosis;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Catabolism;Cause of Death;Cholesterol;Cholesterol Esters;Clinical Trials;Data;Defect;Diabetes Mellitus;Diet;Disease;Dyes;endothelial dysfunction;Enzymes;Evans blue stain;Excretory function;Expenditure;Feces;feeding;Functional disorder;Gene Expression;Genes;Glucose;Health;Healthcare;Hepatic;hepatic lipase;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;human NOS3 protein;Impairment;improved;Individual;insight;Insulin;Insulin Resistance;insulin signaling;Intervention;Investigation;Knock-out;Knockout Mice;Light;Link;Lipids;Lipoproteins;Liver;macrophage;Measures;Mediating;Mediator of activation protein;Metabolic syndrome;Metabolism;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;particle;Pathway interactions;Patients;Phenotype;Physiology;Population;Process;Proteins;public health relevance;Radiolabeled;radiotracer;Regulation;reverse cholesterol transport;Risk Factors;Role;Serum;sphingosine 1-phosphate;SR-BI receptor;Testing;Therapeutic Intervention;tool;Tracer;transcription factor;Transgenic Mice;Triglycerides;United States;uptake;Work,"Insulin action, reverse cholesterol transport, and HDL function",125649,INMP,Integrative Nutrition and Metabolic Processes Study Section,,,1,400000, 8800479,R01,HL,1,N,11/17/2014,11/17/2014,10/31/2015,837,R01HL125815,SCHOOLS OF MEDICINE,PA-13-302,1R01HL125815-01,NHLBI:416250\,Research Projects,2015,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,,US,YALE UNIVERSITY,CT,065103209,"PUBLIC HEALTH RELEVANCE: Many devastating human diseases of the arteries are characterized by excessive smooth muscle which effectively decreases the artery diameter, thereby resulting in inadequate blood flow beyond the narrowing. Herein, we use a genetic mouse model of one such human disease (i.e., supravalvular aortic stenosis) to identify the cellular origins of the excess smooth muscle cells and novel mechanisms underlying their accumulation. These studies promise to identify novel therapeutic strategies to combat human arterial disease. ",8852846;,"GREIF, DANIEL;","OLIVE, MICHELLE ",11/17/2014,10/31/2018,Actins;Adhesions;Aorta;Aortic Valve Stenosis;Arterial Disorder;Arterial Medias;Arteries;arteriole;Atherosclerosis;Attenuated;Blood flow;Blood Vessels;Caliber;Cardiovascular Diseases;Cell Differentiation process;cell motility;Cell Proliferation;Cells;combat;Cytoskeleton;Disease;Distal;dosage;Down-Regulation;effective therapy;Elastin;Embryo;Endothelial Cells;Extracellular Matrix;Gene Dosage;Genes;Genetic;Goals;Growth;Health;Homeobox;Human;human disease;in vivo;induced pluripotent stem cell;injured;Integrins;Intervention;Knockout Mice;Link;Longevity;loss of function mutation;Lung;Maps;Mediating;migration;Mitogens;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;novel;novel therapeutics;null mutation;Operative Surgical Procedures;overexpression;Pathogenesis;Pathology;Pericytes;Phenotype;Plague;Population;postnatal;prevent;public health relevance;Pulmonary Hypertension;pup;receptor;Regulation;response;restenosis;Role;Series;Signal Transduction;Smooth muscle (tissue);Smooth Muscle Myocytes;Source;Stenosis;Stimulus;Sum;Supravalvular aortic stenosis;Testing;Tissues;transcription factor;Transgenic Organisms;Tunica Media;Up-Regulation (Physiology);Vascular Diseases;Work,Pathological arterial muscularization and the role of integrins,125815,VCMB,Vascular Cell and Molecular Biology Study Section,,,1,416250, 8800500,R01,MH,1,N,11/14/2014,11/19/2014,10/31/2015,242,R01MH105416,SCHOOLS OF MEDICINE,PA-13-302,1R01MH105416-01,NIMH:394166\,Research Projects,2015,NATIONAL INSTITUTE OF MENTAL HEALTH,,DURHAM,UNITED STATES,ANATOMY/CELL BIOLOGY,01,,US,DUKE UNIVERSITY,NC,277054673,"PUBLIC HEALTH RELEVANCE: Neuropsychiatric diseases represent a significant health burden, but modern medicine has few curative options for patients suffering from conditions such as schizophrenia and depression. It has become increasingly clear in recent years that neurodevelopmental abnormalities underlie many forms of neuropsychiatric diseases. Both neural progenitor mis-differentiation and functional defects in cholinergic circuit development have been implicated as potential mechanisms for disease, though the connections between these two processes in the brain are poorly understood. Our proposal examines a novel hypothesis that a previously unknown population of cholinergic neurons, in an activity-dependent fashion secreting acetylcholine, can directly control GABAergic interneuron production from neural stem cells in the postnatal subventricular zone (SVZ) niche. Our results from these studies should have a direct impact by unlocking an important gateway connecting neurodevelopmental processes and cholinergic circuit function in health and disease. ",8910612;,"KUO, CHAY TITUS;","PANCHISION, DAVID M",11/19/2014,10/31/2019,Acetylcholine;Acute;Astrocytes;Automobile Driving;base;Behavioral;Behavioral Paradigm;Birth;Brain;Brain region;Cell Communication;Cell Culture Techniques;Cell Proliferation;Cells;Cellular Structures;Cerebral Ventricles;cholinergic;cholinergic neuron;Collaborations;Corpus striatum structure;Cues;Defect;Development;Disease;effective therapy;Electron Microscopy;Environment;Etiology;extracellular;Fibroblast Growth Factor;Frequencies (time pattern);Functional disorder;Glial Fibrillary Acidic Protein;Growth Factor;Health;Housing;Human;human FRAP1 protein;Image;in vivo;Interneurons;Laboratories;Lateral;Life;Light;Measurable;Measures;Mental Depression;Methods;Modeling;Modern Medicine;Molecular;Mono-S;Morphology;mouse model;Mus;Muscarinic Acetylcholine Receptor;nerve stem cell;neural circuit;neuroblast;neurogenesis;Neurons;neuropsychiatry;neurotransmitter release;Neurotransmitters;novel;optogenetics;Pathway interactions;Patients;Pattern;Population;postnatal;presynaptic;Process;Production;public health relevance;Reagent;Regulation;Research;research study;Rodent;Role;Schizophrenia;Science;Signal Transduction;Site;Slice;Source;Specificity;stem cell division;subventricular zone;Synapses;Synaptic Transmission;Testing;Traction;Whole-Cell Recordings,Control of Postnatal SVZ Neurogenesis via Cholinergic Circuit Activity,105416,NCF,Neurogenesis and Cell Fate Study Section,,,1,394166, 8802780,R01,MH,1,N,11/15/2014,11/17/2014,08/31/2015,242,R01MH105513,SCHOOLS OF ARTS AND SCIENCES,PAR-13-055,1R01MH105513-01,NIMH:823705\,Research Projects,2015,NATIONAL INSTITUTE OF MENTAL HEALTH,,BERKELEY,UNITED STATES,PSYCHOLOGY,13,,US,UNIVERSITY OF CALIFORNIA BERKELEY,CA,947045940,"PUBLIC HEALTH RELEVANCE: Mental illness is often severe, chronic and difficult to treat. The sleep disturbance commonly experienced by individuals with a severe mental illness reduces their capacity to function and contributes to key symptoms. This study seeks to determine if an intervention to improve sleep can improve functioning and reduce symptoms and impairment. We will conduct this study in community mental health centers to ensure that the results contribute to closing the worrisome gap between research and practice and ensure that the findings are generalizable to the real world. ",8365495;,"HARVEY, ALLISON G;","RUDORFER, MATTHEW V.",11/17/2014,08/31/2018,Address;Adult;Affect;Aftercare;Area;Arousal;Award;base;Basic Science;behavioral health;Biological Rhythm;Centers for Disease Control and Prevention (U.S.);Chronic;Chronotherapy;Circadian Rhythms;cognitive function;Cognitive Therapy;Communities;Community Mental Health Centers;community setting;Comorbid Insomnia;Comorbidity;County;demographics;Diagnosis;Diagnostic;Diagnostic and Statistical Manual of Mental Disorders;diaries;disability;Disease;efficacy testing;Elements;Ensure;evidence base;Evidence based treatment;Exhibits;experience;follow-up;Foundations;functional disability;Functional disorder;Genetic Complementation Test;Goals;Grant;Health Services;Impairment;improved;improved functioning;Individual;Intervention;intervention effect;Life;Major Depressive Disorder;Measures;Mediating;Mediation;Medical;Mental Depression;Mental disorders;Modeling;motivational enhancement therapy;National Institute of Mental Health (U.S.);novel strategies;Outcome;Outcome Measure;Participant;Patient Self-Report;Patients;performance site;Pharmaceutical Preparations;Phase;physical conditioning;Prevalence;primary outcome;Process;programs;prospective;Protocols documentation;Provider;Psychiatric Diagnosis;public health relevance;Randomized;Randomized Controlled Trials;Recruitment Activity;Regulation;Reporting;Research;Risk Factors;Schedule;Seasons;Services;severe mental illness;Severities;Site;Sleep;Sleep Disorders;Sleep disturbances;Sleeplessness;social;Staging;Symptoms;System;Testing;therapy development;treatment as usual;Treatment Efficacy;United States National Institutes of Health;World Health Organization Disability Assessment Schedule,A transdiagnostic sleep and circadian treatment to improve community SMI outcomes,105513,NRCS,Nursing and Related Clinical Sciences Study Section,,,1,823705, 8806844,R21,MH,1,N,11/18/2014,11/18/2014,10/31/2015,242,R21MH105734,SCHOOLS OF MEDICINE,PA-13-303,1R21MH105734-01,NIMH:233500\,Research Projects,2015,NATIONAL INSTITUTE OF MENTAL HEALTH,,DAVIS,UNITED STATES,PSYCHIATRY,03,,US,UNIVERSITY OF CALIFORNIA AT DAVIS,CA,956186153,"PUBLIC HEALTH RELEVANCE: Antibodies directed at one's own body cause a variety of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. During pregnancy, autoimmune disease can affect the fetus in syndromes such as Graves disease and myasthenia gravis. This application is for funding to study if, and when, antibodies in pregnant rhesus monkeys cross the placenta and ultimately enter the fetal brain. The outcome of this research will have important implications for our proposal that anti-brain antibodies may be one cause of psychiatric illnesses such as autism spectrum disorder. ",1857963;,"AMARAL, DAVID G;","DESMOND, NANCY L",11/18/2014,10/31/2016,Acute;Address;Affect;Age;Animal Model;Animals;Antibodies;autism spectrum disorder;Autoimmune Diseases;Behavior;Behavioral;Binding (Molecular Function);Birth;Blood;Blood Circulation;Brain;Brain Pathology;brain tissue;Child;Collection;Development;Diamond;Disease;Dissection;Dose;Drug Kinetics;Evaluation;Exposure to;fetal;fetal blood;Fetal development of the mammalian embryo or fetus;Fetal Tissues;Fetus;Funding;Gamma counter;Gene Proteins;Glycoproteins;Goals;Growth;Growth and Development function;Human;human subject;Image;Immune response;Immunoglobulin G;Immunology;Individual;Injection of therapeutic agent;interest;intravenous injection;Label;Life;longitudinal positron emission tomography;Macaca mulatta;Maternal antibody;meetings;Membrane;Membrane Proteins;Memory impairment;Mental disorders;Modeling;Monitor;Monkeys;Monoclonal Antibodies;Mothers;Multiple Sclerosis;Myasthenia Gravis;nervous system disorder;Neuraxis;Neurons;Neurosciences;nonhuman primate;offspring;Outcomes Research;Paper;Patient currently pregnant;Phase;Placenta;Positron-Emission Tomography;Pregnancy;pregnant;Protein Databases;Proteins;Protocols documentation;public health relevance;Publications;Radioactivity;Recruitment Activity;Research Personnel;research study;Rheumatoid Arthritis;Second Pregnancy Trimester;Staging;Surface;Syndrome;Systemic Lupus Erythematosus;Testing;Third Pregnancy Trimester;Time;Tissue Harvesting;Tissues,DETECTING THE TRANSFER OF MATERNAL ANTIBODIES INTO THE FETAL RHESUS MONKEY BRAIN,105734,DBD,Developmental Brain Disorders Study Section,,,1,233500, 8823168,R34,MH,1,N,11/18/2014,11/21/2014,10/31/2015,242,R34MH103570,SCHOOLS OF MEDICINE,PAR-12-279,1R34MH103570-01A1,NIMH:254453\,Research Projects,2015,NATIONAL INSTITUTE OF MENTAL HEALTH,,PROVIDENCE,UNITED STATES,PSYCHIATRY,01,,US,BROWN UNIVERSITY,RI,029129002,"PUBLIC HEALTH RELEVANCE: Pregnant and postpartum women with bipolar disorder are at risk for numerous adverse consequences, both for themselves and their developing infants. Treatment is critical during this time, however many perinatal women with BD discontinue treatment during pregnancy. This study will examine the reasons why some pregnant women with BD discontinue their treatment, and others do not. Results of this study will lay the groundwork for developing interventions to help women with BD actively engage in BD treatment during the perinatal period. ",6700492;6772971 (contact);,"BATTLE, CYNTHIA L.;WEINSTOCK, LAUREN M (contact);","AZRIN, SUSAN ",11/21/2014,10/31/2017,Accounting;Address;adverse outcome;Attitude;Belief;Bipolar Disorder;Birth;Caring;Characteristics;Clinical;Cognition;Complex;Counseling;Data;Decision Making;Development;Disease;disorder risk;disturbance in affect;Dose;effective therapy;Empirical Research;Equilibrium;Evaluation;experience;Eye;Fetus;Future;General Population;Impairment;Infant;innovation;Intervention;Interview;Investigation;Lead;Learning;Light;Literature;Manic;Measures;Methods;Microcephaly;Modeling;Moods;Morbidity - disease rate;Mothers;Outcome;Perinatal;Pharmaceutical Preparations;Pharmacotherapy;Phase;Postpartum Period;Postpartum Women;Predisposition;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prenatal;Process;prophylactic;Prospective Studies;Provider;Psychiatric Diagnosis;psychosocial;Psychotic Disorders;public health medicine (field);public health relevance;Publications;Publishing;Qualitative Methods;Recommendation;Recording of previous events;Recruitment Activity;Recurrence;Relative (related person);Research;Research Personnel;Risk;Safety;Sampling;service intervention;severe mental illness;Severities;Shapes;Small for Gestational Age Infant;social stigma;suicidal risk;Symptoms;Testing;Time;Woman,Treatment Decisions for Perinatal Bipolar Disorder,103570,ZMH1,Special Emphasis Panel,,A1,1,254453, 8905355,U58,DP,1,N,09/22/2014,09/30/2014,09/29/2015,541,U58DP005819,,RFA-DP1-4-1419,1U58DP005819-01,NCCDPHP:500000\,Unknown,2014,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,WASHINGTON,UNITED STATES,,98,,US,GEORGE WASHINGTON UNIVERSITY,DC,200520001,,1872990;,"EDBERG, MARK;",,09/30/2014,09/29/2017,,"Avance Center for the Advancement of Immigrant/Refugee Health REACH Project to Address Inadequate Nutrition Among Latinos in Langley Park, MD",5819,ZDP1,Special Emphasis Panel,,,1,500000, 8915935,U58,DP,1,N,09/17/2014,09/30/2014,09/29/2015,,U58DP005957,,RFA-DP1-4-1417,1U58DP005957-01,NCCDPHP:3353274\,Unknown,2014,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,TALLAHASSEE,UNITED STATES,,02,,US,FLORIDA STATE DEPARTMENT OF HEALTH,FL,323997017,,12393963;,"WELLER, ANN-KAREN;",,09/30/2014,09/29/2017,,PARTNERSHIP TO IMPROVE COMMUNITY HEALTH,5957,ZDP1,Special Emphasis Panel,,,1,3353274, 8479814,U79,SM,1,N,07/23/2012,08/01/2012,07/31/2013,,U79SM060465,,RFA-SM-11-002,1U79SM060465-01,,Unknown,2012,Center for Mental Health Services,,MILWAUKEE,UNITED STATES,,04,,US,UNIVERSITY OF WISCONSIN MILWAUKEE,WI,532010340,,11898616;,"KLEIN-TASMAN, BONITA;","BLOGIER, ROSALYN ",08/01/2012,07/31/2015,,UWM Suicide Prevention Project,60465,ZOA1,Special Emphasis Panel,,,1,, 8788906,R01,DA,2,N,06/10/2014,06/15/2014,05/31/2015,279,R01DA007304,SCHOOLS OF MEDICINE,PA-12-293,2R01DA007304-23A1,NIDA:380000\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,MINNEAPOLIS,UNITED STATES,PHARMACOLOGY,05,,US,UNIVERSITY OF MINNESOTA,MN,554552070,"PUBLIC HEALTH RELEVANCE: The neurological impairment associated with HIV infection is due in part to the loss of synaptic connections between neurons. HIV-1-induced synaptic changes may result from a maladaptive response that can be influenced by drugs. This proposal describes experiments to determine how HIV-1 proteins and cannabinoids, drugs given to AIDS patients clinically and widely used illicitly, affect synaptic connections. ",1877469;,"THAYER, STANLEY A;","SORENSEN, ROGER ",03/15/1992,05/31/2019,Acquired Immunodeficiency Syndrome;Affect;Animal Model;base;Behavioral;Biological Assay;Biological Neural Networks;Brain;Cannabinoids;Cell Death Process;Cell Survival;Cells;cognitive function;coping;cytokine;Data;Disease;drug development;drug of abuse;Endocannabinoids;Equilibrium;Excitatory Synapse;Exposure to;Foundations;Funding;Genetic;Hippocampus (Brain);HIV Envelope Protein gp120;HIV Infections;HIV-1;ifenprodil;Image;Impaired cognition;Impairment;improved;improved functioning;In Vitro;Inflammatory;Inhibitory Synapse;insight;Learning;Marijuana Smoking;Measures;Memory;Metabolism;Neurocognitive;Neurodegenerative Disorders;Neurologic;Neurons;neurotoxicity;Neurotoxins;Nitric Oxide;novel;Outcome;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pharmacology;Physiological;Production;Proteins;public health relevance;receptor sensitivity;Recovery;Recovery of Function;release factor;research study;response;Rho-associated kinase;Role;Signal Pathway;Signal Transduction;Site;Synapses;System;tat Protein;Testing;Transgenic Animals;Translating,HIV-1 Neurotoxicity: Mechanism &Modulation by Cannabinoids,7304,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,A1,23,380000, 8182464,R01,EY,2,N,08/04/2011,09/01/2011,01/31/2013,867,R01EY012978,SCHOOLS OF MEDICINE,PA-10-067,2R01EY012978-11,NEI:400802\,Research Projects,2011,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,PHYSIOLOGY,,,US,WEILL MEDICAL COLL OF CORNELL UNIV,NY,100654805,"These studies will provide fundamental information about the strategies the nervous system uses to represent and process information. Since a substantial portion of the work involves mapping the input/output relationship of the retina, this research will also contribute to the development of algorithms for retinal prosthetics.",1905392;,"NIRENBERG, SHEILA A;","GREENWELL, THOMAS ",04/01/2000,01/31/2013,Address;Algorithms;Animals;Applied Research;Back;Basic Science;Behavior;Behavioral Assay;Biological Models;blind;Blindness;Cell model;cell type;Cells;clinically relevant;Code;Complex;Data;Degenerative Disorder;Detection;Development;Devices;Electrodes;Electrophysiology (science);Face;ganglion cell;Gene Transfer;Goals;Grant;Image;improved;information processing;Maps;Measures;Methods;Modeling;Mus;Nervous system structure;Noise;Output;Perception;Performance;Pharmaceutical Preparations;Population;Prosthesis;Research;research study;Resolution;response;Response to stimulus physiology;Retina;Retinal;Retinal Degeneration;Role;Screening procedure;Series;Signal Transduction;Spottings;statistics;Stimulus;System;Testing;tool;Transducers;virtual;Vision;Vision research;Visual;visual process;visual processing;visual stimulus;Work,Population Coding in the Retina,12978,CVP,Central Visual Processing Study Section,,,11,400802, 8786466,R01,NS,2,N,06/12/2014,07/01/2014,06/30/2015,853,R01NS050895,,PA-13-302,2R01NS050895-11,NINDS:646763\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HUNTINGTON BEACH,UNITED STATES,,48,,US,INSTITUTE FOR MOLECULAR MEDICINE,CA,926473652,,1870529 (contact);2061103;,"AGADJANYAN, MICHAEL G (contact);CRIBBS, DAVID HASTINGS;","CORRIVEAU, RODERICK A",09/25/2004,06/30/2019,Affect;aged;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Amyloid deposition;Animals;Antibodies;B-Lymphocyte Epitopes;base;behavior test;Behavioral;Biological Markers;Brain;Brain region;Cells;Cessation of life;Clinic;Clinical;Clinical Research;Cognitive;cognitive function;Combined Vaccines;Consensus;Cyclic GMP;Cytoskeletal Proteins;Data;Data Reporting;Dementia;Development;Diagnosis;Disease;Disease Progression;DNA;DNA Recombinant Proteins;DNA Vaccines;efficacy testing;Elderly;Epitopes;Etiology;Europe;extracellular;Goals;Histocompatibility Antigens Class II;Human;Immunization;immunogenic;immunogenicity;Immunologist;Immunotherapeutic agent;Impaired cognition;improved;Incidence;inhibiting antibody;Lead;Legal patent;Measures;meetings;Molecular;Monkeys;multidisciplinary;Mus;Natural Immunity;Neurofibrillary Tangles;neuron loss;Oryctolagus cuniculus;Pathology;Patients;Peptides;Pharmacologic Substance;Phase I Clinical Trials;prevent;Prevention;prophylactic;public health relevance;Publishing;Recombinant Proteins;Regimen;Reporting;Research Personnel;research study;Role;Safety;Scientist;Series;Symptoms;tau aggregation;tau Proteins;Testing;Tg2576;theories;Therapeutic;therapeutic vaccine;Translating;Treatment Efficacy;Vaccinated;Vaccination;Vaccines;Wild Type Mouse,Combining AD Epitope Vaccine with Innate Immunity,50895,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,,11,646763, 8836863,R13,HD,2,N,11/17/2014,11/20/2014,10/31/2015,865,R13HD036244,SCHOOLS OF MEDICINE,PA-13-347,2R13HD036244-17,NICHD:6000\,Other Research Related,2015,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,MADISON,UNITED STATES,OBSTETRICS &GYNECOLOGY,02,,US,UNIVERSITY OF WISCONSIN-MADISON,WI,537151218,"PUBLIC HEALTH RELEVANCE: The Perinatal Research Society (PRS) membership consists of pediatricians, obstetricians, and basic scientists who are actively engaged in perinatal research. The overall purpose of PRS is two-fold, 1) to provide productive interchange between scientists of different disciplines sharing a common research interest in perinatal biology, and 2) to encourage development and collaboration opportunities for Young Investigators (YI's) to build careers in perinatal research. The annual meeting of the Perinatal Research Society (PRS) establishes a forum in which research at the cutting edge of perinatal medicine and developmental biology can be shared by leading investigators in the three disciplines. Each year the PRS YI Program also invites YI's (those trainees who are transitioning to independent careers, such as Postdoctoral Fellows through Junior Faculty) to join these national leaders in the field. As they consciously learn of new developments they also are given the opportunity to formally and informally discuss their own ideas. These combined activities provide a unique learning experience that would likely not be found at any other scientific function. We seek funding to continue to support a lectureship as part of aim 1 but mostly to support YI attendance and participation in the annual meeting of the Perinatal Research Society (PRS). In this way we can create collaborations and mentoring relationships that can become ongoing and are critical to YI's future research career success. ",1876068;,"BIRD, IAN M;","HIGGINS, ROSEMARY ",04/01/1998,10/31/2019,Award;Biology;career;Career Choice;career development;Child;Child health care;Collaborations;Commit;Critiques;design;Development;Developmental Biology;Discipline;Educational process of instructing;Educational workshop;Electronic Mail;experience;Faculty;falls;Fees;follow-up;Fostering;Foundations;Funding;Future;Goals;Grant;Health Services Research;Hearing;Human Development;Individual;Institutes;interest;Learning;Life;Medicine;meetings;member;Mentors;Mentorship;Monitor;National Institute of Child Health and Human Development;Oral;Outcome;pediatrician;Perception;Performance;Perinatal;Postdoctoral Fellow;Preparation;prevent;Process;programs;Progress Reports;public health relevance;Reporting;Research;Research Personnel;Research Project Grants;Scientist;Social Interaction;Societies;Specialist;success;teacher;Time;United States National Institutes of Health;web site;Writing,Perinatal Research Society Annual Meeting,36244,CHHD,Developmental Biology Subcommittee,,,17,6000, 8960556,R01,AI,3,N,11/19/2014,11/19/2014,02/28/2015,855,R01AI098713,SCHOOLS OF MEDICINE,PA-14-077,3R01AI098713-04S1,NIAID:223021\,Research Projects,2015,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEWARK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,10,,US,RBHS-NEW JERSEY MEDICAL SCHOOL,NJ,071032757, This project will develop blood tests that can detect infections caused by a bioterrorism attack quickly enough to enable life-saving treatment. The tests will be easy to use and they will be designed so that they can be quickly manufactured if a bioterrorism attack should occur. ,1941013;,"ALLAND, DAVID;","RITCHIE, ALEC ",03/07/2012,02/28/2017,Address;assay development;Authorization documentation;Bacteremia;Bacteria;base;Beauty;Biological Assay;Bioterrorism;Blood;Blood Tests;Body Fluids;Buffers;Categories;Characteristics;Clinical;Clinical Sensitivity;Collaborations;Communicable Diseases;Complex;cost;cost effective;Coupled;design;Detection;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostics Research;Disease;DNA;Early treatment;Emergency Situation;Ensure;flexibility;Goals;Hour;Indium;Infection;Influenza;inhibitor/antagonist;innovation;instrument;Laboratories;Licensing;Life;Marketing;Methods;Molecular;Morbidity - disease rate;Mortality Vital Statistics;Nested PCR;New Agents;pathogen;Patients;Plastics;point of care;Polymerase Chain Reaction;Preparation;prevent;Process;Protocols documentation;rapid detection;reagent testing;Recording of previous events;Risk;Sampling;Science;Shipping;Ships;Simulate;Specificity;Specimen;ST14 gene;Staging;Staphylococcus aureus;Stream;Symptoms;Syndrome;System;Techniques;Testing;Virulence;Work,Supplement request for Ebola diagnostic assay development,98713,ZAI1,Special Emphasis Panel,,S1,4,223021, 8970734,R01,GM,3,N,11/19/2014,09/15/2014,08/31/2015,859,R01GM042561,SCHOOLS OF ARTS AND SCIENCES,PA-13-302,3R01GM042561-26S1,NIGMS:94426\,Research Projects,2015,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BALTIMORE,UNITED STATES,CHEMISTRY,07,,US,UNIVERSITY OF MARYLAND BALT CO CAMPUS,MD,212500001,"PUBLIC HEALTH RELEVANCE: The human immunodeficiency virus (HIV) selectively packages two copies of its full-length RNA genome as the virus assembles in infected cells -- a requirement for viral infectivity. Understanding the molecular structures and mechanisms responsible for genome packaging will lead not only to a more detailed understanding of how HIV replicates, but also to the development of new approaches for the treatment of AIDS, cancers, and other virally-induced human diseases. New NMR and hybrid NMR/cryo-EM methodologies developed in the course of these studies should be broadly applicable to the rapidly growing field of RNA biology.",8058334;,"SUMMERS, MICHAEL FINLEY;","SAKALIAN, MICHAEL ",07/01/1989,08/31/2018,Acquired Immunodeficiency Syndrome;Adenosine;Adopted;Affinity;Architecture;base;Base Pairing;Binding (Molecular Function);Binding Sites;Biological Assay;Biology;biophysical techniques;Capsid;Cell membrane;Cells;Chemicals;Complex;Computing Methodologies;Cryoelectron Microscopy;database structure;Detection;Development;dimer;Dimerization;Distant;DNA Sequence Rearrangement;electron tomography;Elements;Engineering;Exhibits;Funding;gag Gene Products;Gagging;Genetic Transcription;Genome;Goals;Health;HIV;HIV-1;HIV-2;human disease;Hybrids;Imagery;in vitro testing;in vivo;Infection;Initiator Codon;insight;Label;Lead;Length;leukemia;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Methodology;Methods;Modeling;Molecular Structure;Moloney Leukemia Virus;monomer;Mus;Mutagenesis;mutant;novel;novel strategies;Nuclear Magnetic Resonance;nucleic acid binding protein;Nucleocapsid;Nucleotides;particle;Physiologic pulse;Property;Protein Fragment;Relative (related person);Relaxation;Reporting;research study;Retroviridae;Ribonucleoproteins;RNA;RNA Splicing;RNA-Protein Interaction;Signal Transduction;Site-Directed Mutagenesis;SIV;stem;stoichiometry;Structure;System;Testing;three dimensional structure;tomography;tool;trafficking;Transfection;Translations;United States National Institutes of Health;Validation;vector;Viral;Virus;Virus Assembly;virus core;Virus Replication;X-Ray Crystallography,NMR Studies of Retroviral Nucleic Acid Binding Proteins,42561,AMCB,AIDS Molecular and Cellular Biology Study Section,,S1,26,94426, 8909864,R01,GM,3,N,11/17/2014,07/01/2014,06/30/2015,859,R01GM057720,SCHOOLS OF MEDICINE,PA-12-149,3R01GM057720-45S1,NIGMS:40063\,Research Projects,2015,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEWARK,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,10,,US,RBHS-NEW JERSEY MEDICAL SCHOOL,NJ,071032757,"PUBLIC HEALTH RELEVANCE: The proposed work will investigate fundamental regulatory mechanisms using the model bacterium Bacillus subtilis, including the process that enables the transfer of virulence and antibiotic resistance genes between bacteria, the formation of biofilms, which in many bacteria is essential for pathogenicity and the formation of resistant spores.",1863237;,"DUBNAU, DAVID A;","GAILLARD, SHAWN R.",06/01/1977,06/30/2018,Acetylation;Animal Model;Anthrax disease;Antibiotic Resistance;Attention;Bacillus subtilis;Bacteria;Binding (Molecular Function);Biochemical;Biological;Biology;cell type;Cells;Clostridium;Communicable Diseases;Communities;Competence;Complex;Decision Making;Development;Developmental Process;DNA;DNA Binding;Environment;Event;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genomics;Grant;Health;Helix-Turn-Helix Motifs;Heterogeneity;Human body;Image;Indwelling Catheter;interest;Investigation;Laboratories;Life Cycle Stages;Logic;Lysine;Mediating;Medical;Methods;Microbial Biofilms;Modeling;Octodon;OmpR protein;Organism;pathogen;Pathogenicity;Phosphorylation;Play;Post-Translational Protein Processing;Probability;Process;programs;Protein Acetylation;protein degradation;protein-histidine kinase;Proteins;public health medicine (field);Regulation;Reproduction spores;Resistance;respiratory;response;Role;Signal Transduction;Signal Transduction Pathway;Stochastic Processes;Stress;System;Tetanus;Time;transcription factor;Virulence;Work,Regulation of genetic competence in Bacillus subtilis,57720,,,,S1,45,40063, 8909608,R01,GM,3,N,11/17/2014,05/01/2014,02/28/2015,859,R01GM096000,SCHOOLS OF MEDICINE,PA-12-149,3R01GM096000-03A1S1,NIGMS:18213\,Research Projects,2015,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CLEVELAND,UNITED STATES,BIOCHEMISTRY,11,,US,CASE WESTERN RESERVE UNIVERSITY,OH,441067015,"PUBLIC HEALTH RELEVANCE: Cell function depends on enzymes to dramatically increase of the rates of biochemical reactions and they are the target of numerous diagnostics, drugs and clinical therapy. The research will for the first time test directly how enzymes that are important for human health and pathogenesis increase rates of reactions involving the formation and breakage of RNA and DNA chains. ",1886222;,"HARRIS, MICHAEL E.;","BARSKI, OLEG ",09/15/2011,02/28/2018,Acids;Active Sites;Address;Amino Acid Substitution;base;Benchmarking;Biochemical Reaction;Biological;Catalysis;catalyst;Catalytic RNA;Cell physiology;Characteristics;Charge;Chemicals;Chemistry;Chicago;Cleaved cell;Clinical;cofactor;Collaborations;computational chemistry;Data;design;Development;Diagnostic;DNA;drug development;Electrostatics;Environment;Enzymatic Biochemistry;Enzyme Inhibitor Drugs;Enzyme Inhibitors;enzyme mechanism;Enzymes;Geometry;Goals;Health;Human;Individual;inhibitor/antagonist;insight;Investigation;Ions;Isoenzymes;Isotopes;Kinetics;Left;Light;Measures;Mechanics;Metals;Methods;Modeling;Molecular;Mutation;novel;nucleobase;Nucleotides;Oligonucleotides;Pancreatic ribonuclease;Pathogenesis;Pharmaceutical Preparations;Proteins;protonation;Protons;public health relevance;quantum;Reaction;reaction rate;Research;research study;RNA;simulation;Solutions;Solvents;Structure;Study models;System;Technical Expertise;Testing;theories;Therapeutic;therapeutic target;Time;Transferase,Mechanistic Enzymology of Phosphoryl Transfer Enzymes,96000,,,,A1S1,3,18213, 8969037,R13,AR,3,N,11/18/2014,09/01/2014,08/31/2015,350,R13AR067088,,PA-13-347,3R13AR067088-01S1,NCATS:10000\,Other Research Related,2015,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SAN RAFAEL,UNITED STATES,,02,,US,NATIONAL ALOPECIA AREATA FOUNDATION,CA,949150760,"PUBLIC HEALTH RELEVANCE: If this research summit achieves the long-term goal of leading to a safe, affordable treatment or cure for alopecia areata, the public health burden for the 6.5 Million Americans living with this disease will be reduced or eliminated.",1879630;,"NORRIS, DAVID A.;","CIBOTTI, RICARDO ",09/01/2014,08/31/2015,Address;Affect;Age;Alopecia Areata;American;Animal Model;Autoimmune Diseases;Autoimmune Process;base;Biological Products;career;Clinical Research;Clinical Trials;Collaborations;Comorbidity;Dermatology;Development;Disabled Persons;Discipline;Disease;disease natural history;Ensure;Equilibrium;Ethnicity aspects;Family member;Fostering;Foundations;Funding;Future;Genetic;Genomics;Goals;Government Agencies;Grant;Hair;Health;Hearing;Heredity;Immune Targeting;Immunology;improved;innovation;Insulin-Dependent Diabetes Mellitus;Knowledge;Lead;Learning;Life;medical specialties;meetings;Methods;Minority;Mission;Monitor;Nonprofit Organizations;Participant;Patients;Phototherapy;posters;Process;psychologic;public health medicine (field);Published Comment;Publishing;Race;Registries;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Research Support;Risk;Seasons;Series;social;Talents;Testing;Time;United States National Institutes of Health;Voice;Woman,Accelerating Autoimmune Treatments through Alopecia Areata Research,67088,AMS,Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee,,S1,1,10000, 8971106,U2G,GH,3,N,11/20/2014,09/30/2014,03/31/2015,,U2GGH001116,,RFA-GH1-3-1366,3U2GGH001116-01S1,COGH:112950\,Unknown,2015,COORDINATING OFFICE OF GLOBAL HEALTH,,WASHINGTON,UNITED STATES,,98,,US,AMERICAN SOCIETY FOR MICROBIOLOGY,DC,200362904,,11762916;,"SPECTER, STEVEN;",,09/30/2014,03/31/2019,,"GH13-1366, HQ, AMERICAN SOCIETY FOR MICROBIOLOGY",1116,ZGH1,Special Emphasis Panel,,S1,1,112950, 8961105,U50,CC,3,N,11/18/2014,09/01/2014,08/31/2015,,U50CK000431,,RFA-CK1-4-1402,3U50CK000431-01S1,COGH:190000\,Other Research Related,2015,CENTERS FOR DISEASE CONTROL AND PREVENTION,,GENEVA,SWITZERLAND,,,,SZ,WORLD HEALTH ORGANIZATION,,1211,,12286780;,"ISABELLE, NUTTALL;",,09/01/2014,08/31/2019,,ADDRESSING EMERGING INFECTIOUS DISEASES AND THE INTERNATIONAL HEALTH REGULATIONS,431,ZCK1,Special Emphasis Panel,,S1,1,190000, 8769148,F30,CA,5,N,11/14/2014,11/16/2014,11/15/2015,398,F30CA168323,SCHOOLS OF ARTS AND SCIENCES,PA-11-110,5F30CA168323-03,NCI:47676\,"Training, Individual",2015,NATIONAL CANCER INSTITUTE,,CHAMPAIGN,UNITED STATES,CHEMISTRY,13,,US,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,IL,618207406,"The proposed research supports the NIH and NCI's core missions to advance knowledge and improve public health through the development of novel anti-cancer therapeutics. Through the biological development of these N-hydroxyindole class lactate dehydrogenase A (LDH-A) inhibitors, this project will help push a promising, targeted and selective anti-cancer agent into the clinics.",10425943;,"CALVARESI, EMILIA;","DAMICO, MARK W",11/16/2012,11/15/2017,Address;Advanced Development;Adverse effects;Animals;anti-cancer therapeutic;Antineoplastic Agents;base;Binding (Molecular Function);Biological;Biological Assay;Cancer Biology;cancer cell;Cancer cell line;Cancerous;Carboxylic Acids;Cell Culture Techniques;Cell Line;Cells;Cleaved cell;Clinic;Clinical Trials;Data;design;Development;Dose;drug candidate;Enzymes;Equipment;Esters;Glucose;glucosidase;Glutamine;Glycolysis;Goals;Human;hydroxyindole;Hypoxia;Immune response;improved;In Vitro;inhibitor/antagonist;Institution;interest;Knowledge;Label;lactate dehydrogenase A;liquid chromatography mass spectrometry;Malignant Neoplasms;Mammals;Metabolism;Methods;Mission;N.I.H. Research Support;NMR Spectroscopy;novel;outcome forecast;overexpression;Pharmaceutical Preparations;Prodrugs;Production;Property;public health medicine (field);Pyruvate;Reporting;Research;Research Project Grants;research study;Research Training;Resources;SLC2A1 gene;Surface Plasmon Resonance;Techniques;Testing;Therapeutic;Time;Tissues;Toxic effect;Training;tumor metabolism;tumor microenvironment;Warburg Effect,Biological characterization of a novel class of lactate dehydrogenase A (LDH-A) i,168323,ZRG1,Special Emphasis Panel,,,3,47676, 8753071,F31,CA,5,N,11/21/2014,11/16/2014,11/15/2015,398,F31CA183499,HOSPITALS,PA-11-112,5F31CA183499-02,NCI:34607\,"Training, Individual",2015,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,BIOCHEMISTRY,09,,US,UNIVERSITY OF TX MD ANDERSON CAN CTR,TX,770304009,"PUBLIC HEALTH RELEVANCE: This proposal utilizes the well-established Mus musculus model to uncover the necessity of a multifunctional transcription factor in normal mammary gland development and tumorigenesis. While we have evidence that TRIM24 over-expression levels in breast cancer is correlated with poor patient prognosis, we do not know if this is a causative relationship. This work will illuminate the function of TRIM24 in normal breast biology as well as breast cancer malignancy which can lead to the use of TRIM24 as a predictive measure in breast cancer malignancy or redundancy, potentially leading to the development of targeted drugs. ",11169610;,"DUNCAN, AUNDRIETTA DE VAN;","VALLEJO-ESTRADA, YOLANDA ",11/16/2013,11/15/2015,Address;Affect;Aging;aluminum sulfate;American;American Cancer Society;Binding (Molecular Function);Biological Assay;Biology;Breast;Breast Cancer Cell;Breast Epithelial Cells;Bromodomain;Carmine;Cell Death;Cells;Chromatin;Clinic;cohort;Complex;Data;Development;Diagnosis;Diagnostic;Disease;Drug Targeting;Ectopic Expression;embryonic stem cell;Epithelium;Epitopes;ERBB2 gene;Estrogen Receptors;Gene Amplification;Genes;genetic profiling;Goals;Hematoxylin and Eosin Staining Method;Histones;Hormones;House mice;Human;In Vitro;in vivo;Individual;Knowledge;Lactation;Lead;Location;Maintenance;malignant breast neoplasm;Malignant Neoplasms;mammary epithelium;Mammary gland;mammary gland development;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Oncogenes;Oncogenic;outcome forecast;Patients;Pattern;Phenotype;Play;Pregnancy;Proteins;Proto-Oncogenes;public health relevance;Reader;receptor function;reconstruction;Recruitment Activity;Research Personnel;research study;Role;Signal Transduction;Staging;Staining method;Stains;The Cancer Genome Atlas;therapeutic target;Time;Tissues;transcription factor;Transgenic Mice;Translations;Treatment Efficacy;TRIM Gene;TRIM Motif;tumor;Tumor Suppressor Proteins;tumorigenesis;ubiquitin-protein ligase;Western Blotting;Woman;Work,Understanding the Function of TRIM 24 in Mammary Epithelial Cells,183499,ZRG1,Special Emphasis Panel,,,2,34607, 8765623,F31,GM,5,N,11/14/2014,11/16/2014,11/15/2015,859,F31GM106731,SCHOOLS OF MEDICINE,PA-11-112,5F31GM106731-02,NIGMS:28318\,"Training, Individual",2015,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,BIOCHEMISTRY,02,,US,TEMPLE UNIV OF THE COMMONWEALTH,PA,191226027,"PUBLIC HEALTH RELEVANCE: Control of STIM Expression and Function by Interplay between EGR Family Members Store Operated Calcium entry, a major pathway of Ca2+ entry in non-excitable cells, plays a critical role in T cell survival and activation. Here we propose tht regulation of STIM1 and other Ca2+ homeostatic proteins by EGR family members is crucial for Ca2+ dependent immunological activity. Deregulated activity in T cells leads to multiple pathophysiological outcomes including Severe Combined Immunodeficiency (SCID) and autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis.",11489991;,"SAMAKAI, ELSIE;","GAILLARD, SHAWN R.",11/16/2013,11/15/2016,Affect;Antibodies;Antigen Presentation;Apoptosis;Autoimmune Diseases;base;Binding (Molecular Function);Biological Assay;Biological Models;Ca(2+)-Transporting ATPase;Calcineurin;Calcium;Calmodulin;CD28 gene;CD3 Antigens;Cell membrane;Cell model;Cell Nucleus;Cell physiology;Cell Survival;cell type;Cells;chromatin immunoprecipitation;Complex;crosslink;cytokine;defined contribution;Dependence;Electrophoretic Mobility Shift Assay;Embryo;EMSA;Ensure;Enzyme-Linked Immunosorbent Assay;Event;Family member;Fibroblasts;Fluorescence;Generations;Genetic Transcription;Growth;Health;Homeostasis;Hour;Inflammatory Bowel Diseases;Investigation;Knock-out;Luciferases;Measures;Mediating;Membrane;Metabolic Clearance Rate;Multiple Sclerosis;Mus;novel;nuclear factors of activated T-cells;Outcome;Pathway interactions;Phosphoric Monoester Hydrolases;Physiological;Play;Process;Promotor (Genetics);Proteins;receptor;Receptor Activation;receptor expression;receptor-mediated signaling;Regulation;Relative (related person);research study;response;Response Elements;Rheumatoid Arthritis;Role;Series;Severe Combined Immunodeficiency;Signal Transduction;Signaling Molecule;Small Interfering RNA;STIM1 gene;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Time;Tissues;transcription factor;Transcriptional Regulation;Transfection;vector;Zinc Fingers,Control of STIM Expression and Function by Interplay Between EGR Family Members,106731,ZRG1,Special Emphasis Panel,,,2,28318, 8760211,F31,NR,5,N,10/30/2014,11/16/2014,02/15/2015,361,F31NR013821,SCHOOLS OF ARTS AND SCIENCES,PAR-11-117,5F31NR013821-02,NINR:8236\,"Training, Individual",2015,NATIONAL INSTITUTE OF NURSING RESEARCH,,AURORA,UNITED STATES,OTHER HEALTH PROFESSIONS,06,,US,UNIVERSITY OF COLORADO DENVER,CO,800452570,PUBLIC HEALTH RELEVANCE: Mexican-origin adolescent females in the U.S. are at higher risk for childbirth than their white peers. This mixed methods project will contribute to a more thorough understanding of how cultural constructions of gender and sexuality mediate the relationship between structural factors and reproductive health behaviors of Mexican- origin adolescent females. The findings will be used to design interventions to reduce reproductive health disparities and improve the quality of life of Mexican-origin adolescent females. ,11176511;,"COLEMAN MINAHAN, KATE T.;","BANKS, DAVID ",11/16/2013,02/15/2015,Acculturation;Address;Adolescent;Age;aged;Attitude;base;Behavior;behavior change;behavior influence;Behavioral;Biological;Birth;Birth Rate;Categories;child bearing;Childbirth;Clinical;Colorado;Commit;Communities;Complex;Contraceptive methods;Contraceptive Usage;Country;Coupled;Data;Data Analyses;Disadvantaged;Discipline of Nursing;Economics;Ethnic group;experience;Female Adolescents;First Births;Focus Groups;Gender;Generations;Goals;Grant;Health;Health behavior;health disparity;health economics;health equity;Heterogeneity;high risk;Hispanics;HIV;Immigrant;improved;Incentives;Individual;Intervention;Interview;Investigation;Latina;Latino;life history;Literature;Longevity;Longitudinal Studies;Mediating;meetings;Methods;Mexican;Mexico;Minority;National Institute of Nursing Research;National Research Service Awards;Nurses;Nursing Research;Pattern;peer;Persons;Population;population health;Poverty;public health relevance;Quality of life;Race;rapid growth;Reproductive Health;Research;Research Project Grants;Research Training;Risk;Risk Factors;Role;Science;Scientist;segregation;sex;Sexuality;skills;Strategic Planning;Structure;Surveys;teenage mother;therapy design;Time;Training;United States,Acculturation and Reproductive Health Disparities in Mexican-Origin Adolescents,13821,NRRC,Nursing Science Review Committee,,,2,8236, 8762403,F32,AI,5,N,10/30/2014,11/16/2014,11/15/2015,855,F32AI104380,,PA-11-113,5F32AI104380-03,NIAID:55094\,"Training, Individual",2015,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,,12,,US,J. DAVID GLADSTONE INSTITUTES,CA,941582261,"PUBLIC HEALTH RELEVANCE: The discovery of a cure for HIV is currently out of reach, hindered by the virus's ability to lay silent in a dormant state within the DNA of a human cell. This inactive or latent state reactivates at a later time, causing elevated levels of HIV, AIDS, an ultimately the death of an infected individual. By building on evidence that latency is heavily influenced by HIV-1 gene expression, this project aims to mechanistically understand how altering viral gene expression affects HIV latent stability using diverse biochemical approaches that modulate its expression and latent reactivation resulting in research of interests to the HIV and systems biology communities.",11138772;,"DAR, ROY DAVID;","STANSELL, ELIZABETH H.",11/16/2012,11/15/2015,Acquired Immunodeficiency Syndrome;Affect;Anti-Retroviral Agents;base;Biochemical;Bioinformatics;Biological Assay;Cells;Cessation of life;Classification;clinically relevant;Communities;Data;Data Set;DNA;Drug Combinations;drug mechanism;Elements;Flow Cytometry;Frequencies (time pattern);Gene Activation;Gene Expression;Genetic;Genetic Transcription;Goals;Health;Hexamethylene Bisacetamide;high standard;HIV;HIV-1;Human;Individual;interest;Interruption;Life;Machine Learning;Maintenance;mathematical model;Measurement;Measures;Modeling;multidisciplinary;Mutate;Mutation;Noise;novel;novel strategies;Outcomes Research;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phenotype;Physiologic pulse;Preclinical Drug Evaluation;Probability;Promotor (Genetics);purge;reactivation from latency;Regulation;Regulatory Element;Relative (related person);Research;Role;Science;System;Systems Biology;Technology;Testing;Time;tool;Variant;Viral;Viral Genes;Virus;Vorinostat,The Role of Transcriptional Noise in the Establishment of HIV-1 Latency,104380,ZRG1,Special Emphasis Panel,,,3,55094, 8771426,F32,AR,5,N,11/14/2014,11/16/2014,11/15/2015,846,F32AR063508,SCHOOLS OF MEDICINE,PA-11-113,5F32AR063508-03,NIAMS:59432\,"Training, Individual",2015,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,STANFORD,UNITED STATES,DERMATOLOGY,18,,US,STANFORD UNIVERSITY,CA,943041222,"This proposal aims to further characterize the role of long, non-coding RNAs in epidermal homeostasis and differentiation. Defects in epidermal differentiation are a hallmark of several skin diseases, and improving our understanding of the molecular regulators of skin differentiation can provide insight into the cause and potential treatment for these conditions.",10746017;,"SUN, BRYAN;","BAKER, CARL ",11/16/2012,11/15/2015,alveolar lamellar body;base;Beryllium;Binding (Molecular Function);Biological Assay;Biology;Cell Cycle Regulation;Cell physiology;Complex;Cytoplasmic Granules;Data;Defect;Down-Regulation;Elements;Epithelial;filaggrin;Foundations;Functional RNA;Future;Genes;Genetic;Genetic Epistasis;Genomics;Goals;Homeostasis;Human Genome;Immune;improved;Individual;insight;Keratin;keratinocyte differentiation;Knowledge;Laboratories;Literature;loricrin;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;Molecular;Molecular Mechanisms of Action;molecular modeling;Molecular Models;mRNA Transcript Degradation;mutant;Names;National Research Service Awards;novel;Phenocopy;pluripotency;Process;programs;Protein Microchips;Proteins;Regulation;research study;RNA;RNA Binding;RNA Interference;RNA-Binding Proteins;RNA-Protein Interaction;Role;Series;Skin;skin disorder;Specificity;Stem cells;Surveys;Testing;Tissue Model;Tissues;trafficking;Transcript;Untranslated RNA;Work,Role of Noncoding RNAs in Epidermal Differentiation,63508,ZRG1,Special Emphasis Panel,,,3,59432, 8769153,F32,GM,5,N,11/20/2014,11/16/2014,11/15/2015,859,F32GM103238,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,5F32GM103238-03,NIGMS:53282\,"Training, Individual",2015,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,CHEMISTRY,13,,US,UNIVERSITY OF CALIFORNIA BERKELEY,CA,947045940,"PUBLIC HEALTH RELEVANCE: Synthetically-challenging nitrogen-containing rings are found in countless medicinally-active molecules. In this proposal, a novel nickel-catalyzed reaction will be developed to allow the fast, convenient construction of these functionalities from readily available starting material. This approach uses cheap, abundant catalysts and precursor, and may potentially be amenable to the large-scale production of pharmaceuticals in industry.",11031288;,"WINSTON, MATTHEW STEVEN;","BARSKI, OLEG ",11/16/2012,11/15/2015,Alkenes;Amino Alcohols;antineoplastic antibiotics;Aziridines;Biological Factors;carbene;Carbon Dioxide;Carbon Monoxide;Catalysis;catalyst;combinatorial;Complex;Decarboxylation;Development;discount;drug discovery;Electron Spin Resonance Spectroscopy;Evaluation;Exhibits;Health;Industry;insight;Lactams;large scale production;Libraries;Ligands;Magnetic Resonance;Mediating;Methods;Modeling;molecular recognition;Nickel;Nitrogen;novel;Nuclear;Oxazolidinones;Pathway interactions;Pharmacologic Substance;pharmacophore;Phase;planetary Atmosphere;Property;pyrrolidine;Pyrrolidines;pyrroline;Reaction;research study;screening;Solvents;synthetic drug;Therapeutic;Transition Elements;Work,"Effecting C-O activation of oxazolidinones by Ni to construct small, chiral heter",103238,ZRG1,Special Emphasis Panel,,,3,53282, 8769107,F32,GM,5,N,11/14/2014,11/18/2014,11/17/2015,859,F32GM106690,SCHOOLS OF ARTS AND SCIENCES,PA-11-113,5F32GM106690-02,NIGMS:55094\,"Training, Individual",2015,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DURHAM,UNITED STATES,BIOLOGY,01,,US,DUKE UNIVERSITY,NC,277054673,"PUBLIC HEALTH RELEVANCE: The sequencing revolution has revealed that many human diseases cannot be linked to single genes, but instead are complex and multigenic. Thus, understanding how genes interact is critical for public health. Insights gained from understanding gene networks in Arabidopsis may be generally applicable to all organisms, including humans. ",11167599;,"WINTER, CARA;","REDDY, MICHAEL K.",11/18/2013,11/17/2015,Arabidopsis;Behavior;Biology;Cell division;cell fate specification;Cell Lineage;Cells;Complex;Data;daughter cell;Development;Differential Equation;Event;Fluorescence;Foundations;Future;Genes;Genetic Research;Goals;Human;human disease;Image;Imaging Techniques;Individual;insight;Kinetics;Knowledge;Laboratory Organism;Laser Scanning Confocal Microscopy;Life;Light;Link;mathematical model;Measures;Methods;Microscopy;Modeling;network architecture;Organism;Output;Pattern;Plant Roots;Plants;Production;Property;protein expression;Proteins;public health medicine (field);public health relevance;Regulator Genes;Research;research study;response;Solid;Spectrum Analysis;Stem cells;stoichiometry;Study models;Techniques;Time;Tissues;tool;transcription factor;two-photon;Work,Dynamics of the SHR-SCR Network Controlling Asymmetric Cell Division,106690,ZRG1,Special Emphasis Panel,,,2,55094, 8762231,I01,VA,5,N,11/21/2014,10/01/2014,09/30/2015,999,I01BX000502,,RFA-BX-12-001,5I01BX000502-06,,Research Projects,2015,Veterans Affairs,,HOUSTON,UNITED STATES,,09,,US,MICHAEL E DEBAKEY VA MEDICAL CENTER,TX,770304211,"PUBLIC HEALTH RELEVANCE: Project Narrative Platelet microparticles are submicron size, membrane enclosed fragments, released from platelets upon activation. We propose that microparticles deliver microRNA to endothelium. Understanding the consequences this phenomenon will unravel new mechanisms of cell communication and provide new diagnostic, therapeutic or prognostic tools. ",1884407;,"THIAGARAJAN, PERUMAL;",,10/01/2009,09/30/2017,acute coronary syndrome;Adhesives;angiogenesis;Antiphospholipid Syndrome;Apoptosis;Atherosclerosis;Biological Markers;Blood;Blood flow;Blood Platelets;Cell Adhesion Molecules;Cell Communication;cell motility;Cell physiology;Cell surface;Cells;Cirrhosis;Coagulation Process;Coenzymes;Complex;cytokine;Deep Vein Thrombosis;Defect;Development;Diabetes Mellitus;Disease;Endothelial Cells;Endothelium;Extravasation;Fibroblasts;Gene Expression;Glycoproteins;Hematopoietic;Hemorrhage;Hemostatic function;Heparin;HIV Infections;In Vitro;in vivo;Inherited;intercellular communication;Ischemic Stroke;Malignant Neoplasms;Mediating;Mediator of activation protein;Membrane;MicroRNAs;neoplastic cell;novel;novel diagnostics;Permeability;Phosphatidylserines;Phospholipids;Physiological;Plasma;Platelet Activation;Platelet-Derived Growth Factor;Play;prognostic;Property;public health relevance;receptor;response;Role;Rupture;Scott syndrome;Sepsis;submicron;Surface;Therapeutic;Thrombocytopenia;Thrombotic Thrombocytopenic Purpura;Time;tool;uptake;Vascular Diseases;Vesicle,Platelet Microvesicles,502,HEMA,Hematology,,,6,, 8764689,I01,VA,5,N,11/17/2014,10/01/2014,09/30/2015,999,I01BX001266,,RFA-BX-10-006,5I01BX001266-04,,Research Projects,2015,Veterans Affairs,,PALO ALTO,UNITED STATES,,,,US,VETERANS ADMIN PALO ALTO HEALTH CARE SYS,CA,943041207,"The identification of Cancer Stem Cells (CSCs) will establish previously unidentified cellular target(s) for more effective diagnostics and therapies in deadly cancers affecting Veterans such as malignant gliomas (MGs). Since there are hundreds of possible CSC cell surface markers that could identify CSCs, it is critical to develop a powerful screening technology to identify candidate markers before initiating time-consuming and costly validation assays. We have thus begun development on a novel live cell microarray, called the Colony- Forming Antibody Cell Array (CFACA), which can separate living MG cells into thousands of cell subpopulations based on cell surface marker expression and assess which one(s) are enriched for CSC behavior while growing on the actual CFACA. We propose to further develop and validate this novel technology in order to identify CSCs in the MG cells taken directly from surgical specimens. While the focus of this work is to study MGs, the CFACA can be applied to identify CSCs in any cancer affecting Veteran patients.",1905211;,"SKIRBOLL, STEPHEN L;",,10/01/2011,09/30/2015,Advanced Development;Affect;Agar;Antibodies;base;Basic Science;Binding (Molecular Function);Biological Assay;Brain Neoplasms;Cancer Biology;cancer cell;Cancer stem cell;candidate marker;cell behavior;Cell Cycle;Cell Line;Cell surface;Cells;cellular targeting;Characteristics;clinically relevant;Colon Carcinoma;Color;combinatorial;Complex;Development;Diagnostic;glioma cell line;Heterogeneity;Histology;Human;human tissue;Immunodeficient Mouse;implantation;In Vitro;in vivo;insight;leukemia;Life;malignant breast neoplasm;Malignant Glioma;Malignant Neoplasms;Methylation;MGMT gene;Molecular Profiling;Mus;neoplastic cell;new technology;novel;Operative Surgical Procedures;Pathogenesis;Patients;Phenotype;Population;Printing;Proliferating;Promotor (Genetics);Property;Proteins;Regimen;screening;self-renewal;Sensitivity and Specificity;Sorting - Cell Movement;Specimen;Spottings;Staining method;Stains;Stem cells;Surgical Replantation;Techniques;Technology;Testing;Time;time use;tool;Translational Research;Transplantation;tumor;tumor growth;Validation;Veterans;Work;Xenograft procedure,A Novel Colony-Forming Antibody Cell Array to Identify Human Cancer Stem Cells,1266,ONCA,Oncology A,,,4,, 8795688,I01,VA,5,N,11/18/2014,04/01/2014,03/31/2015,999,I01BX001473,,RFA-BX-11-001,5I01BX001473-03,,Research Projects,2015,Veterans Affairs,,LOS ANGELES,UNITED STATES,,33,,US,VA GREATER LOS ANGELS HEALTHCARE SYSTEM,CA,900731003,"The mechanistic studies proposed in this application on the function of the extracellular calcium-sensing receptor (CaSR) using genetically modified mice and human colon- derived cells in culture are of importance to define the role of the CaSR in the regulation of intestinal epithelial cell proliferation and consequently, are of high significance for Colorectal Cancer (CRC) and Inflammatory Bowel Disease (IBD). The completion of the proposed studies will provide a robust intellectual framework for targeting the colonic CaSR in the chemoprevention of CRC in US veterans as well as in the US population at large.",6774619;,"ROZENGURT, JUAN ENRIQUE;",,04/01/2012,03/31/2016,Ablation;Adult;Amino Acids;Architecture;Aromatic Amino Acids;base;beta catenin;Calcium-Sensing Receptors;Cell membrane;Cell Nucleus;Cell physiology;Cell Proliferation;cell type;Cells;Cessation of life;Chemoprevention;Chief Cell;Colon;colonic crypt;Colorectal Cancer;crypt cell;Diet;Down-Regulation;Employee Strikes;Epithelial Cell Proliferation;Epithelial Cells;extracellular;Family;G-Protein-Coupled Receptors;gastrointestinal system;Gastrointestinal tract structure;General Population;Genetic;Genetic Transcription;GTP Binding;Homeostasis;Hormones;Human;human disease;in vivo;Inflammation;Inflammatory Bowel Diseases;intestinal homeostasis;Intestines;Ions;Knockout Mice;Life;Maintenance;Malignant Neoplasms;Mediating;member;migration;mouse model;Mucous Membrane;Mus;novel;Nutrient;Organ;Organism;Parathyroid gland;Pathogenesis;Peptides;phospholipase C beta;Phosphorylation;Play;Population;prevent;Process;protective effect;Protein Dephosphorylation;Publishing;Receptor Activation;Receptor Signaling;Regulation;response;restoration;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Stimulus;Stratum Basale;Time;Tissues;Veterans;Wound Healing,Calcium-sensing receptor signaling in the regulation of colonic epithelial cells,1473,GAST,Gastroenterology,,,3,, 8762439,I01,VA,5,N,11/18/2014,10/01/2014,09/30/2015,999,I01BX001726,,RFA-BX-12-001,5I01BX001726-03,,Research Projects,2015,Veterans Affairs,,BOISE,UNITED STATES,,02,,US,BOISE VA MEDICAL CENTER,ID,837024501,"PUBLIC HEALTH RELEVANCE: Severe group A streptococcal soft tissue infections have been described in civilians of all ages and in veterans in VA hospitals and nursing homes. Mortality and morbidity of this infection remain high, especially in elderly individuals, despite appropriate antibiotic treatment and intensive care measures. Survivors frequently require several months of acute care hospitalization and rehabilitation due to consequences of shock and cardiac failure and to the loss of muscle groups or entire extremities as a result of life-saving surgical debridement. This proposal will investigate the mechanisms underlying the cardiomyopathy associated with StrepTSS. Results of these studies will define a series of potential interventions to treat, preven and attenuate the severity of illness at distinct molecular levels. Consequently, these experimental results could be translated into novel therapeutic strategies to improve the management of patients with StrepTSS, thereby shortening hospital stay, reducing morbidity and improving outcome.",2406252;,"STEVENS, DENNIS L;",,10/01/2012,09/30/2016,Acute;Affect;Age;Animals;Antibiotic Therapy;Attenuated;Bacteremia;base;Binding (Molecular Function);Blindness;Calcium;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiomyopathies;Cardiovascular Abnormalities;Caring;Cells;Chronic Disease;Clinical;Collagen;collagenase 3;Congestive;Contracts;cooperative study;Coronary Vessels;cytokine;Cytoplasm;Debridement;demographics;design;Deterioration;Development;Digit structure;Dilated Cardiomyopathy;Double-Blind Method;Echocardiography;Elderly;Environment;Enzyme-Linked Immunosorbent Assay;Enzymes;Exposure to;extracellular;Family;Fibroblasts;follow-up;Functional disorder;Gangrene;Gene Expression;Goals;Health;Heart;Heart failure;heart function;hemodynamics;Histocompatibility Testing;Histopathology;Hospitalization;Hospitals;Hypertension;Hypokinesia;Hypotension;Impaired cognition;Impairment;improved;In Vitro;in vivo Model;Individual;Infection;Infiltration;Inflammatory;Inflammatory Infiltrate;Intensive Care;Intervention;Laboratories;Length of Stay;Life;limb amputation;Limb structure;Matrix Metalloproteinases;Measures;Mechanics;Medical;Molecular;Morbidity - disease rate;Mortality Vital Statistics;Multi-Institutional Clinical Trial;Mus;Muscle;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardium;Myofibrils;Necrosis;novel;novel therapeutics;Nursing Homes;Operative Surgical Procedures;Organ;Organ failure;Organism;Outcome;Pathway interactions;Patients;Peripheral;Phase;prevent;Production;Proteins;Rehabilitation therapy;response;reuptake;Role;scaffold;septic;Septic Shock;Series;Severities;Severity of illness;Shock;Soft Tissue Infections;Stimulus;Streptococcus pyogenes;streptolysin O;Stress;Structural Protein;Structure;Survivors;Swelling;System;Thrombosis;Tissues;Toxic Shock Syndrome;Toxin;Translating;Up-Regulation (Physiology);Vascular constriction (function);Vasoconstrictor Agents;Veterans;Virulence Factors;Wild Type Mouse;Work;Zinc,Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs,1726,INFB,Infectious Diseases B,,,3,, 8764627,I01,VA,5,N,11/20/2014,10/01/2014,09/30/2015,999,I01BX001784,,RFA-BX-12-001,5I01BX001784-02,,Research Projects,2015,Veterans Affairs,,MATHER,UNITED STATES,,07,,US,VA NORTHERN CALIFORNIA HEALTH CARE SYS,CA,956554200, This project aims to develop a multi-functional nanomicelle drug delivery system that can specifically deliver the chemotherapeutic drug paclitaxel to bladder cancer. The nanomicelle system can possibly improve treatment efficacy and lower therapy-associated toxicity. ,8570062;,"PAN, CHONG-XIAN;",,10/01/2013,09/30/2017,Binding (Molecular Function);Biocompatible;Bladder;Blood Cells;Calmette-Guerin Bacillus;cancer cell;Cancer cell line;Cancer Control;Canis familiaris;Cells;Chronic Cystitis;Clinical;Companions;Data;density;Detection;Development;Doctor of Medicine;Doctor of Philosophy;Drug Delivery Systems;drug distribution;drug efficacy;Drug Formulations;Drug Kinetics;Fibroblasts;Funding;Goals;Homing;Human;Image;Immunocompromised Host;improved;in vivo;intravenous injection;K-Series Research Career Programs;Knowledge;Ligands;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mentors;Monitor;Mus;Names;nanotherapeutic;novel;Organ;outcome forecast;Paclitaxel;Patients;peptide analog;Peptides;Pharmaceutical Preparations;Pharmacology and Toxicology;Pilot Projects;preclinical study;public health relevance;Site;Specimen;Structure;Surface;System;targeted delivery;Therapeutic;Therapeutic Effect;Time;Toxic effect;Treatment Efficacy;Treatment outcome;tumor xenograft;Urothelial Cell;Vascular Endothelial Cell;Work;Xenograft procedure,Development of targeting nanotherapeutics against bladder cancer,1784,ONCA,Oncology A,,,2,, 8762445,I01,VA,5,N,11/19/2014,10/01/2014,09/30/2015,999,I01BX001923,,RFA-BX-12-001,5I01BX001923-03,,Research Projects,2015,Veterans Affairs,,PALO ALTO,UNITED STATES,,,,US,VETERANS ADMIN PALO ALTO HEALTH CARE SYS,CA,943041207,"PUBLIC HEALTH RELEVANCE: Steroid hormones are produced by the adrenal gland and gonads. They influence carbohydrate, lipid and protein metabolism, and salt and water balance, as well as immunity and blood pressure, whereas gonadal steroids are critical for secondary sex characteristics, fertility and muscle and bone growth. It is well established that aging in Veterans, like the general population, leads to a decline in testosterone production in men and alteration in adrenal steroid production in both sexes. The goal of this project is to establish the causal role of excessive oxidative stress in age-related decline in steroid hormone production in animal models. Successful completion of these studies may identify potential molecular targets that can be exploited in the development of new therapies to treat aging-induced testosterone deficiency in men and adrenal steroid- related diseases. These studies should also help in understanding the pathogenesis of diabetes, neurodegenerative diseases, and heart disease, where oxidative stress is believed to play an important role.",1865125;,"AZHAR, SALMAN;",,10/01/2012,09/30/2016,"2,2,6,6-tetramethyl-4-piperidinol-N-oxyl;Acetylcysteine;Address;age related;Aging;Animal Genetics;Animal Model;Animals;Antioxidants;Attenuated;attenuation;Biochemical;Blood Pressure;Bone Growth;carbohydrate metabolism;Carrier Proteins;cell age;Cell Aging;Cells;Cellular biology;Cholesterol;Defect;Development;Diabetes Mellitus;Disease;Down-Regulation;ebselen;Elderly;Enzymes;Equilibrium;EUK-189;Excision;Fertility;Free Radical Formation;General Population;Gland;Goals;Gonadal Steroid Hormones;Gonadal structure;Health;Heart Diseases;hormone regulation;Hormones;Human;Immunity;In Vitro;Inner mitochondrial membrane;Intervention;Kinetics;Laboratories;leydig interstitial cell;Life;Link;lipid metabolism;Manganese Superoxide Dismutase;MAP Kinase Gene;MAPK14 gene;Measures;Mediating;men;mimetics;Mitochondria;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;Molecular Biology Techniques;Molecular Target;Molecular Weight;Monitor;mouse model;mRNA Expression;Mus;Muscle;Neurodegenerative Disorders;Oxidants;oxidative damage;Oxidative Stress;Pathogenesis;Play;Pregnenolone;prevent;Process;Production;protein expression;protein metabolism;Proteins;Rattus;Resistance;response;Role;senescence;sex;Sex Characteristics;Side;Signal Transduction;Site;Sodium Chloride;Steroid biosynthesis;steroid hormone;steroidogenic acute regulatory protein;Steroids;Sterols;Testing;Testosterone;Tissue Model;treatment effect;Veterans;Water",Role of Cholesterol in Age-related Decline in Steroidogenesis,1923,ENDA,Endocriniology A,,,3,, 8811007,I01,VA,5,N,11/20/2014,10/01/2014,09/30/2015,999,I01BX002324,,RFA-BX-13-001,5I01BX002324-02,,Research Projects,2015,Veterans Affairs,,PALO ALTO,UNITED STATES,,,,US,VETERANS ADMIN PALO ALTO HEALTH CARE SYS,CA,943041207,"PUBLIC HEALTH RELEVANCE: The major focus of our work is to understand the cellular and molecular mechanisms that lead to fibrosis of muscle in the setting of injury, diseases, and aging. Fibrosis is associated with th kind of scarring that leads to changes in muscle that reduces muscle strength and increases muscle stiffness. A population of stem cells known as fibroadipogenic progenitors, or FAPs, exists within skeletal muscle, and it has been suggested that these cells may be responsible for some or even most of the degenerative changes that occur when muscle regeneration is impaired. The goal of our studies is to understand what mechanisms control the fate and function of these FAPS and to determine the extent to which we can modulate the behavior of these cells in order to reduce the amount of fibrosis that develops in muscle, whether in injury, degenerative diseases, or aging. Our long-term goals are to develop therapies for enhancing muscle regeneration and function in order to improve the health and quality of life of Veterans with muscle injuries and muscle dysfunction. ",1878892;,"RANDO, THOMAS A.;",,10/01/2013,09/30/2017,3'Untranslated Regions;Activities of Daily Living;Acute;Adult;Affect;Age;age related;aged;Aging;base;cell behavior;Cell Culture Techniques;Cell Therapy;Cells;Cicatrix;Clinical;Collagen;combat;Connective Tissue;Data;Degenerative Disorder;Deposition;Development;Disease;Effectiveness;Exhibits;experience;Fatty acid glycerol esters;Fibrosis;Functional disorder;Genes;Goals;Health;improved;In Vitro;in vivo;indexing;Infiltration;inhibitor/antagonist;Injury;insight;Introns;Investigation;Lead;Ligands;Link;Mission;Molecular;Muscle;muscle aging;Muscle Contraction;Muscle function;muscle regeneration;Muscle satellite cell;muscle strength;Natural regeneration;Pancreas;Pathology;Pathway interactions;Pattern;PDGFRB gene;Phosphorylation;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor alpha Receptor;Polyadenylation;Population;Population Study;Post-Transcriptional Regulation;prevent;Production;progenitor;Proteins;public health relevance;Quality of life;Recovery;regenerative;Regulation;response;response to injury;RNA Sequences;Role;Signal Pathway;Signal Transduction;Site;skeletal;Skeletal muscle injury;Skeletal muscle structure;Skin;Specificity;stem cell biology;stem cell population;Testing;Therapeutic;therapeutic development;therapy development;tissue repair;tool;Transcript;Transplantation;Trauma;Untranslated Regions;Variant;Veterans;Work,Regulation of Muscle Fibrosis in Response to Injury and Aging,2324,CAMM,Cellular and Molecular Medicine,,,2,, 8768459,I01,VA,5,N,11/17/2014,10/01/2014,09/30/2015,999,I01CX000584,,RFA-CX-11-001,5I01CX000584-03,,Research Projects,2015,Veterans Affairs,,PALO ALTO,UNITED STATES,,,,US,VETERANS ADMIN PALO ALTO HEALTH CARE SYS,CA,943041207,"PUBLIC HEALTH RELEVANCE: Each year, over 350,000 veterans within the VA are diagnosed with Alcohol Abuse or Dependence (AUD) and approximately 2/3 of these veterans are between 40 and 60 years of age. Clearly, increased knowledge of mid-to-later life alcoholism is essential for the development of more efficient and effective interventions tailored to this population. The current project will contribute to this knowledge base by identifying predictors of successful remission, differentiating those with AUD in terms of differences in the developmental course of the disorder, and identifying barriers to treatment and alternative treatment interventions that are more likely to engage the large number of veterans with AUD who do not seek out conventional treatment.",1861279;,"JACOB, THEODORE;",,10/01/2012,09/30/2016,Accidents;Address;Age;age group;Age-Years;Aging;Alcohol abuse;Alcohol dependence;alcohol use disorder;Alcoholism;Alcohols;alternative treatment;Attention;Automobile Driving;base;Characteristics;Chronic;Clinical;clinically relevant;Consumption;conventional therapy;coping;Country;Data;data registry;Data Set;Development;Diagnosis;Disease;Disease remission;drinking;drinking onset;effective intervention;Elderly;Event;Evidence based treatment;falls;Family;Foundations;Future;Generations;Genetic;Goals;Grant;Health;health administration;Health Personnel;Healthcare Systems;Individual;Intervention;Knowledge;knowledge base;Life Cycle Stages;Measures;Medical;medical specialties;Mental disorders;middle age;Occupational;Outcome;Patients;Pattern;Personality;Phase;Planning Techniques;Population;Primary Health Care;Principal Investigator;Procedures;Progress Reports;prospective;Recording of previous events;Registries;Relapse;Reporting;Research;Sampling;Severities;social;socioeconomics;Time;Twin Multiple Birth;Twin Studies;Veterans;Vietnam;Work;young adult,Alcoholism Course From Drinking Onset to Late Life,584,EPID,Epidemiology,,,3,, 8768467,I01,VA,5,N,11/17/2014,10/01/2014,09/30/2015,999,I01CX000792,,RFA-RX-11-013,5I01CX000792-03,,Research Projects,2015,Veterans Affairs,,PALO ALTO,UNITED STATES,,,,US,VETERANS ADMIN PALO ALTO HEALTH CARE SYS,CA,943041207,"PUBLIC HEALTH RELEVANCE: This project will study 206 Gulf War 1 (GW1) veterans identified with symptoms understood to characterize Gulf War Illness, including a primary ICD-9 diagnosis fibromyalgia type pain. Following screening and informed consent, veterans will be randomly assigned to treatment with repetitive transcranial magnetic stimulation (rTMS) or sham rTMS (placebo). Additional examinations will compare brain imaging (PET-FDG) across participants. Although the VA population is similar to the general population in many respects, there are important differences. It also differs significantly from the populations that have been included in prior trials of rTMS or many conditions such as Depression, chronic pain and fibromyalgia. Most notably, the veteran population exhibits a 9.6% prevalence rate of fibromyalgia type pain in non-GW1 veterans and a 19.2% prevalence rate of these symptoms in GW1 veterans - compared to a prevalence rate of 2.0% in the general population (Iowa Persian gulf Study Group, 1997;Wolf, Ross, Anderson, Russell and Hebert, 1995).",9009758;,"ASHFORD, JOHN WESSON;",,10/01/2012,09/30/2016,Accounting;Affect;Aftercare;Age;Anxiety;Anxiety Disorders;Area;Brain imaging;Caring;Chronic;chronic pain;Cognitive;cognitive function;Comorbidity;cost;cost effectiveness;Data;depressive symptoms;Dermatologic;Diagnosis;Disease remission;Eligibility Determination;Exhibits;Fatigue;FDA approved;Fibromyalgia;follow-up;gastrointestinal;General Population;Genes;Genetic;Genetic Markers;Gulf War;Health;health related quality of life;Healthcare Systems;ICD-9;Impaired cognition;improved;Individual;Informed Consent;Iowa;Measures;Mental Depression;Metabolic;Motor Cortex;Pain;Participant;Patients;Persian Gulf;Placebos;Population;Positron-Emission Tomography;Post-Traumatic Stress Disorders;Prevalence;Quality of life;Randomized;Recovery;Rehabilitation therapy;repetitive transcranial magnetic stimulation;Research;Resistance;respiratory;response;Safety;screening;Series;Severities;Substance abuse problem;Symptoms;treatment response;Veterans;Wolves,rTMS for the Treatment of Chronic Pain in GW1 Veterans,792,RRD4,Psychological Health &Social Reintegration ,,,3,, 8959897,I01,VA,5,N,11/21/2014,07/01/2013,06/30/2014,999,I01RX000288,,RFA-RX-11-013,5I01RX000288-02,,Research Projects,2015,Veterans Affairs,,TEMPLE,UNITED STATES,,31,,US,OLIN TEAGUE VETERANS CENTER,TX,765047451,"Families of veterans returning from the current Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF) and Operation New Dawn (OND) conflicts are at increased risk for consequences of Substance Abuse Disorder (SUD) including familial alcohol misuse. Whereas several effective treatment programs have been developed and are readily accessible to these individuals, returning OEF/OIF/OND veterans are often particularly reluctant to seek treatment. Within civilian populations, the Community Reinforcement and Family Training (CRAFT) intervention has been proven to be effective at increasing the success of concerned significant others in motivating SUD partners to treatment. The goal of the current study is to determine whether this treatment can be applied to the concerned significant other partners of OEF/OIF/OND veterans in order to improve treatment seeking. This objective is consistent with the VHA Uniform Mental Health Services Codes.",1878934;,"GULLIVER, SUZY B;",,07/01/2012,06/30/2016,Address;Aftercare;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol misuse;Alcohol or Other Drugs use;Alcohols;arm;Attenuated;base;Behavior;Caring;Child;Clinical Trials Design;Code;Communities;Conflict (Psychology);coping;Data;Disease;drinking;Educational Intervention;Educational process of instructing;effective therapy;efficacy testing;Emotional;Enrollment;Evidence based treatment;Exposure to;Family;Family member;Freedom;Frequencies (time pattern);Generations;Goals;Guidelines;Health;Health Services;Health Services Accessibility;Healthcare Systems;improved;Individual;innovation;Intervention;intervention program;knowledge base;Laws;Learning;Legal;Length;Life Experience;Mental Health;Mental Health Services;Methods;Military Personnel;operation;Outcome;Outcome Measure;Outpatients;Parents;Participant;Patients;peer;Phase;physical conditioning;Population;Post-Traumatic Stress Disorders;primary outcome;Psychological reinforcement;Psychopathology;public health relevance;Randomized;Randomized Clinical Trials;reduced substance abuse;Reporting;Research;research study;Resistance;Risk;Sampling;secondary outcome;Spouses;Stress;stress related disorder;Substance abuse problem;substance abuse treatment;Substance Use Disorder;success;successful intervention;Symptoms;Testing;therapy design;therapy development;Training;Translating;Treatment Efficacy;treatment program;Veterans;willingness,"Motivating Substance Abusing Veterans, via Family to Seek Treatment",288,RRD4,Psychological Health &Social Reintegration ,,,2,, 8959937,I01,VA,5,N,11/21/2014,08/01/2014,07/31/2015,999,I01RX000505,,RFA-RX-11-013,5I01RX000505-03,,Research Projects,2015,Veterans Affairs,,DECATUR,UNITED STATES,,04,,US,VETERANS HEALTH ADMINISTRATION,GA,300334004,"Relevance of Proposed Research to VA Patient Care Mission: This research directly addresses the mission of the VA by attending to quality-of-life mandates. The number of Veterans age 85 years and older has tripled this decade (VetData, 2010). Older Veterans, particularly those over 85, are among the most vulnerable of the veteran population and are at highest risk for suffering fall-related injuries. An estimate of outpatient costs to the VA in 2001 for fall-related injuries as nearly $3.3 million for the initial visit alone (Luther, 2005). The potential for large economic savings by reducing falls incidence, thus fall-related injuries, is evident. Given the increased incidence of falls with age and the morbidity associated with falls, the results of this study willbe relevant to a substantial number of veterans. The proposed study has the potential to develop novel rehabilitation approaches to reduce the risk of falls in older veterans with dizziness. This project will contribute to improved quality of life and containment of health care costs in the elderly.",1952795;,"HALL, COURTNEY;",,08/01/2012,07/31/2015,Address;Age;age related;analog;Balance training;conditioning;Containment;cost;Data;design;Diagnosis;Diagnostic;disability;Disease;Dizziness;Economics;Elderly;Elements;equilibration disorder;Equilibrium;Esthesia;Evaluation;Exercise;Eye Movements;fall risk;falls;Functional disorder;Gait;gaze;Goals;Head Movements;Health Care Costs;high risk;Home environment;human very old age (85+);Impairment;improved;Incidence;indexing;Individual;Injury;Intervention;Lightheadedness;Measures;Medical;Mission;Morbidity - disease rate;Motion;Movement;novel;older patient;otoconia;Outcome Measure;Outpatients;Participant;Pathology;Patient Care;Patients;Physical therapy;Pilot Projects;Placebos;Population;programs;Quality of life;Randomized;Recovery;Regression Analysis;Rehabilitation Outcome;Rehabilitation therapy;Research;Risk Factors;Risk Reduction;Savings;Semicircular canal structure;Sensory;Sonal;Speed (motion);Symptoms;Testing;Time;Vestibular Diseases;Vestibular loss;Veterans;Visit;Visual;Visual Acuity,Vestibular rehabilitation and dizziness in geriatric patients,505,RRD3,Sensory Systems/Communication ,,,3,, 8959938,I01,VA,5,N,11/21/2014,10/01/2014,09/30/2015,999,I01RX000523,,RFA-RX-11-013,5I01RX000523-03,,Research Projects,2015,Veterans Affairs,,PORTLAND,UNITED STATES,,03,,US,PORTLAND VA MEDICAL CENTER,OR,972392964,"Multiple sclerosis (MS) affects approximately 2.5 million people worldwide and approximately 400,000 Americans. Fatigue occurs in 75-95% of people with MS and is often their most disabling symptom. There are over 6,000 Veterans who are service connected for MS and approximately 20,000 Veterans with MS receive care through Veterans Health Administration (VHA) in any one year. Currently the VHA spends $274 million treating Veterans with MS at an average cost per patient per year of $19,875. Fatigue limits day to day function, participation in family and community and health related quality of life. With few symptomatic therapies, demonstrating that any new treatment for fatigue in MS is effective would be a significant innovation to improve care. Should we demonstrate in this randomized well-powered trial with appropriate controls that Fatigue: Take Control (FTC) is effective, there will be an educational program with proven efficacy to offer Veterans with MS. FTC is available at all NMSS chapters and all VAMC for cost-effective implementation.",6441880;,"BOURDETTE, DENNIS NEIL;",,10/01/2012,09/30/2016,Address;Affect;American;arm;Baltimore;base;blind;Budgets;Caring;Clinic;clinical practice;Clinical Practice Guideline;Clinical Trials Design;Communities;Community Health;Consult;cost;cost effective;Country;Data;diaries;disabling disease;Educational aspects;Effectiveness;Enrollment;Ensure;Evaluation;Evidence based treatment;Exercise;Family;Fatigue;follow-up;Goals;Guidelines;health administration;health related quality of life;Hour;improved;Individual;Information Management;innovation;Intervention;Language;Least-Squares Analysis;Life;Location;Maintenance;Measures;medical schools;Minority;Modeling;Monitor;Multiple Sclerosis;Nature;Neuraxis;novel;Nurses;Occupational Therapist;Outcome Measure;Participant;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Physical activity;Pilot Projects;pilot trial;Practice Guidelines;primary outcome;programs;Publishing;Quality of life;Randomized;Randomized Clinical Trials;randomized trial;Recommendation;Recruitment Activity;Regression Analysis;Reporting;Research;Research Personnel;Research Project Grants;response;Self Efficacy;Series;Services;SF-36;Side;Site;social;Socialization;Societies;Structure;Symptoms;Testing;Time;Training;Travel;treatment trial;Variant;Veterans;Wages;Woman,A randomized trial of a formal group program for fatigue in multiple sclerosis,523,RRD6,Aging &Neurodegenerative Disease ,,,3,, 8499097,IK1,VA,5,N,11/20/2014,07/01/2013,06/30/2014,999,IK1RX000805,,RFA-RX-11-019,5IK1RX000805-02,,Other,2015,Veterans Affairs,,BALTIMORE,UNITED STATES,,07,,US,BALTIMORE VA MEDICAL CENTER,MD,212011524,"Type two diabetes is a growing problem among all older adults, particularly Veterans. The majority of Veterans with diabetes are in poor physical health and they are significantly more impaired, with functional limitations, if they have neuropathy. An intervention with sustained, long-term benefits on two of the common disabilities associated with diabetes;mobility and neuropathy will potentially have major effects on health outcomes that are important to all older Veteran with diabetes. These outcomes include prevention of catastrophic diabetic complications, maintenance of personal independence, improved quality of life, and decreased costs for medical and personal care over time. If the proposed research determines that a lifestyle intervention has long term, sustained benefits on mobility and neuropathy progression as well as on levels of physical activity this intervention will be replicable and able to reach th large number of older Veterans with diabetes within the integrated VA Health System.",10513208;,"ZILLIOX, LINDSAY;",,07/01/2012,06/30/2014,aging population;Baltimore;base;Biopsy;blood glucose regulation;Clinical;clinical effect;Clinical Research;Clinical Trials;Complications of Diabetes Mellitus;cost;Counseling;Data;density;Diabetes Mellitus;Diabetic Neuropathies;Diet;diet and exercise;disability;Dropout;effective therapy;Elderly;Exercise;experience;Fellowship;follow-up;Follow-Up Studies;Funding;Healed;healing;Health;Health system;Home environment;improved;improving mobility;instrument;interest;Intervention;journal article;lifestyle intervention;Long-Term Effects;Maintenance;Maryland;Master of Science;Measurement;Measures;Medical;Mentors;Mentorship;Monitor;Nerve Fibers;Nerve Regeneration;Neurology;Neuropathy;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Participant;Patients;Peer Review;Performance;Peripheral Nervous System Diseases;Physical activity;physical conditioning;prevent;Prevention;professor;programs;Publishing;Quality of life;Questionnaires;Rehabilitation therapy;Research;research and development;Research Personnel;research study;Research Training;Self Care;Series;Skin;Surveys;Symptoms;Testing;Time;time interval;Training;Universities;Utah;Veterans;Walking;Work,Long Term Effects of Diet and Exercise on Early Diabetic Neuropathy,805,RRD9,Blank,,,2,, 8960298,IK2,VA,5,N,11/21/2014,09/01/2013,08/31/2014,999,IK2RX000748,,RFA-RX-11-020,5IK2RX000748-02,,Other,2015,Veterans Affairs,,MOUNTAIN HOME,UNITED STATES,,01,,US,JAMES H QUILLEN VA MEDICAL CENTER,TN,376840000,"High-frequency sensorineural hearing loss (HFL) affects up to 93% of males in the United States aged 60-69 years and 57% of men aged 40-49 years. Veterans with hearing loss typically have more noise exposure and are older than the general population;these circumstances both contribute to HFL. Between 2008 and 2009 compensable claims for impaired hearing grew 12.4%, which was more than any other body system impairment and middle-aged adults (35-54 years) accounted for 30% of those Veterans (Annual Benefits Report FY2009, p. 9-10). Currently, it is not understood in what way early aging and HFL contribute to reduced temporal processing and speech understanding. The knowledge gained by this research will provide direct benefit to Veterans suffering from HFL by better rehabilitative strategies (e.g., auditory training) or devices (e.g., processors for hearing aids).",10217145;,"LEIGH-PAFFENROTH, ELIZABETH D.;",,09/01/2012,08/31/2015,Accounting;Acoustics;Address;Adult;Affect;Age;age effect;age related;aged;Aging;Audiology;Audiometry;Auditory;Auditory Evoked Potentials;Auditory system;base;Basic Science;Behavioral;body system;Clinic;Clinical;Code;Complex;Computer software;Detection;Development;Devices;Diagnostic;Discrimination (Psychology);Electrophysiology (science);Equipment;experience;Experimental Designs;FarGo;Florida;Frequencies (time pattern);General Population;Goals;Hearing;Hearing Aids;hearing impairment;High-Frequency Hearing Loss;Home environment;Impairment;improved;Individual;insight;Instruction;Knowledge;Laboratories;Literature;male;Masks;Measurement;Measures;men;Mentors;Methods;middle age;Noise;Participant;Patients;Perception;Performance;Physiological;Play;Process;Psychophysics;public health relevance;Recovery;Recruitment Activity;Rehabilitation therapy;relating to nervous system;Reporting;Research;Research Personnel;research study;response;Sensorineural Hearing Loss;Series;Short-Term Memory;signal processing;Signal Transduction;skills;Speech;Speech Perception;speech processing;Stimulus;Techniques;Technology;Testing;Time;Training;Translating;United States;Universities;Veterans;Wisconsin;young adult,High-Frequency Hearing Loss and Early Aging Effects on Auditory Temporal Coding,748,RRD8,Blank,,,2,, 8959942,IK2,VA,5,N,11/21/2014,09/01/2014,08/31/2015,999,IK2RX000755,,RFA-RX-11-020,5IK2RX000755-03,,Other,2015,Veterans Affairs,,TAMPA,UNITED STATES,,14,,US,JAMES A. HALEY VA MEDICAL CENTER,FL,336124745,"This proposed research will advance rehabilitation science by investigating outcomes (physical function, seating interface pressures, Health Care Acquired Pneumonia) of CLC Veterans. The proposed research will provide descriptive data for a provisional conceptual model that fits the Geriatric and Extended Care (GEC) Strategic Plan: a conceptual ... rehabilitative model ... of healthy aging, acute illness and injury in advanced age... A novel wheelchair positioning intervention will provide needed supports for posture that confers greater health to older Veterans and is Veteran-centric. The intervention will be developed with staff caregivers who will provide it in the future. It will fulfill the goal to Modify and promote evidence-based preventive services by: (a) adding to the evidence base for GEC Veterans, (b) adding to preventive services for GEC veterans by preventing complications of immobility, and (c) reducing dependency.",10350908;,"BARKS, LELIA SAUNDERS;",,09/01/2012,08/31/2017,Acute;Adult;Amputees;Back;Caregivers;CLC Gene;Clinical;clinical practice;Code;Cognitive;cost effective;Costs and Benefits;Data;Data Collection;Decubitus ulcer;Dependency (Psychology);design;Device or Instrument Development;Elderly;Elements;Environment;Ethnicity aspects;evidence base;Frequencies (time pattern);Future;Gender;Goals;Growth;Health;Healthcare;healthy aging;Hip region structure;Hour;Incidence;indexing;Injury;Instruction;instrument;Intervention;Interview;Lateral;Length;Location;Long-Term Care;Manual wheelchair;Measures;Methods;Minority;Modeling;Musculoskeletal Equilibrium;novel;Nursing Staff;Observational Study;Outcome;Outcome Measure;Phase;Physical Function;Pilot Projects;Pneumonia;Policies;Positioning Attribute;Posture;Powered wheelchair;pressure;Prevalence;prevent;Preventive;Psychometrics;Race;Randomized Controlled Trials;rehabilitation science;Rehabilitation therapy;Research;Sample Size;Sampling;Series;Services;Skin;Specific qualifier value;Spinal cord injury;Strategic Planning;Surface;System;Technology;Testing;therapy development;Thigh structure;Time;Training;Veterans;Wheelchairs;Woman,Wheelchair Seated Posture and Health Outcomes for CLC Residents,755,RRD9,Blank,,,3,, 8760312,R01,ES,5,N,11/19/2014,11/01/2014,10/31/2015,113,R01ES021534,SCHOOL OF MEDICINE &DENTISTRY,PA-11-260,5R01ES021534-03,NIEHS:484964\,Research Projects,2015,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,ROCHESTER,UNITED STATES,PUBLIC HEALTH &PREV MEDICINE,25,,US,UNIVERSITY OF ROCHESTER,NY,14627,"PUBLIC HEALTH RELEVANCE: By examining epigenetic changes in brain coupled with brain neurotransmitters and stress hormones, these studies will determine how positive vs. negative behavioral experience after birth could either reverse/alleviate or even further worsen the epigentic as well as behavioral, neurotransmitter and stress-related effects of developmental exposures to low levels of lead or prenatal stress alone or in combination. ",7355758 (contact);1887119;,"CORY-SLECHTA, DEBORAH A (contact);SCHNEIDER, JAY S;","HOLLANDER, JONATHAN ",12/01/2012,10/31/2017,Adrenal Glands;Adult;Age;base;Behavior;Behavior Therapy;Behavioral;Biological;Birth;Blood;blood lead;boys;Brain;brain behavior;Child;Cognitive deficits;cohort;Communities;Control Groups;Corticosterone;Coupled;Data;Development;Disease;Disease model;DNA;DNA Methylation;DNA Sequence;Elderly;Epigenetic Process;epigenome;epigenomics;Evaluation;executive function;experience;Exposure to;Female;fetal;Foundations;frontal lobe;Functional disorder;Gender;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Hippocampus (Brain);Histone Acetylation;Homeostasis;Hormones;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impaired cognition;Intervention;Lead;lead exposure;low socioeconomic status;male;Mediating;Mediation;Methylation;monoamine;mRNA Expression;Mus;Nature;Neurotransmitters;NR3C1 gene;Nucleus Accumbens;Pathology;Physiological;Pituitary Gland;Plastics;postnatal;Predisposition;prenatal stress;public health relevance;Receptor Gene;Reporting;resilience;response;restoration;Risk;Risk Factors;Rodent;Sampling;sex;Stress;System;Testing;Toxic effect,CNS Glucocorticoid Epigenetic Changes of Pb Stress Effects,21534,NAL,Neurotoxicology and Alcohol Study Section,,,3,484964, 8774548,R01,HD,5,N,11/18/2014,11/01/2014,10/31/2015,865,R01HD054681,ORGANIZED RESEARCH UNITS,PA-11-260,5R01HD054681-12,NICHD:289462\,Research Projects,2015,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT,,NEW BRUNSWICK,UNITED STATES,NONE,06,,US,"RUTGERS, THE STATE UNIV OF N.J.",NJ,089018559,"PUBLIC HEALTH RELEVANCE: Although the events of fertilization are fairly well described for a number of species, the molecular underpinnings of the process are not well understood. We are identifying the molecules and molecular mechanisms of fertilization in the model system Caenorhabditis elegans. This work will complement studies of fertilization in other species and could eventually lead to a better understanding of the causes of infertility, the diversity of reproductive strategies and the design of new contraceptives. ",1970984;,"SINGSON, ANDREW W;","MOSS, STUART B.",05/01/2001,10/31/2018,Address;Affect;Area;Biochemical;Biological;Biological Models;Biological Process;Biology;Caenorhabditis elegans;Cell Communication;Cells;Collection;Complement;Contraceptive Agents;design;economic implication;egg;Equipment and supply inventories;Event;Fertility Study;Fertilization;gene function;Genes;Genetic;genetic analysis;Genetic Screening;genome sequencing;Germ Cells;Goals;Health;Human;Infertility;innovation;insight;Lead;Medical;Methods;Modeling;Molecular;Molecular Analysis;Molecular Genetics;molecular modeling;Molecular Models;Mutagenesis;mutant;Mutation;Nature;Nematoda;Oocytes;Organism;Pathway interactions;Phenotype;positional cloning;Process;reproductive;reproductive success;Research;Role;social implication;Solid;sperm cell;sperm function;Sperm-Ovum Interactions;Sterility;tool;Work,Gamete Interactions in Caenorhabditis elegans,54681,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",,,12,289462, 8515835,U79,SM,5,N,07/11/2013,08/01/2013,07/31/2014,,U79SM060465,,RFA-SM-11-002,5U79SM060465-02,,Unknown,2013,Center for Mental Health Services,,MILWAUKEE,UNITED STATES,,04,,US,UNIVERSITY OF WISCONSIN MILWAUKEE,WI,532010340,,11896445;,"KLEIN-TASMAN, BONNIE;","BLOGIER, ROSALYN ",08/01/2012,07/31/2015,,UWM Suicide Prevention Project,60465,ZOA1,Special Emphasis Panel,,,2,, 8959965,F32,GM,7,N,11/17/2014,08/01/2014,01/31/2015,859,F32GM105266,,PA-11-113,7F32GM105266-03,NIGMS:26641\,"Training, Individual",2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WORCESTER,UNITED STATES,,02,,US,UNIV OF MASSACHUSETTS MED SCH WORCESTER,MA,016550002,"PUBLIC HEALTH RELEVANCE: Several major disease-causing bacteria contain in their arsenal pore-forming toxins - secreted proteins that form dangerous holes in the surfaces of our cells - but cells have evolved methods to defend themselves against these attacks and other forms of membrane damage. Because many of the genes required for these defensive cellular responses against pore-forming toxins are also involved in cancer and other diseases, our research, aimed at providing a deeper understanding of the mechanism of defense against pore-forming toxins, will lead to greater insight into and potentially greater therapies for treatig bacterial infection and other human diseases.",9948308;,"SITARAM, ANAND;","SAKALIAN, MICHAEL ",02/01/2013,01/31/2015,Actins;Animals;Bacillus anthracis;Bacteria;Bacterial Infections;base;Biological Assay;Caenorhabditis elegans;Candidate Disease Gene;Cell membrane;Cell physiology;Cells;cellular microvillus;Complex;Cytoskeleton;Defense Mechanisms;Destinations;Disease;disorder control;Endocytosis;Epithelial Cells;Event;Family member;feeding;Genes;genome-wide;Health;Homologous Gene;Human;human disease;Image;Individual;Infection Control;insight;Intestines;knock-down;Lead;Life;Light;Link;Malignant Neoplasms;Mammalian Cell;Mammals;MAPK14 gene;Mediating;Mediator of activation protein;Membrane;Membrane Protein Traffic;Membrane Proteins;Methods;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Monomeric GTP-Binding Proteins;mutant;Nematoda;pathogen;Pathogenesis;Pathway interactions;Pattern;Play;Polycystic Kidney Diseases;Process;programs;Protein Family;Proteins;Publishing;Regulation;Reporter;Research;response;RNA Interference;Role;Signal Induction;Signal Transduction;Signal Transduction Pathway;Staphylococcus aureus;stress-activated protein kinase 1;Surface;System;Testing;Toxin;trafficking;Vesicle;Vibrio cholerae;Virulence Factors;Wiskott-Aldrich Syndrome;Yeasts,Cellular responses to pore-forming toxins and regulation/function of the exocyst,105266,ZRG1,Special Emphasis Panel,,,3,26641, 8960377,K01,HS,7,N,11/21/2014,09/06/2014,04/30/2015,226,K01HS018546,SCHOOLS OF MEDICINE,PAR-09-087,7K01HS018546-06,,Other Research Related,2014,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,ANN ARBOR,UNITED STATES,NONE,12,,US,UNIVERSITY OF MICHIGAN,MI,481091274,PUBLIC HEALTH RELEVANCE: The proposed project has the potential to positively impact public health by creating more accurate estimators of healthcare provider outcome quality and cost and by contributing to the understanding of the effect of hospital-based pay-for-performance. This research can be used to design payment policy that creates stronger incentives for value and quality improvement in healthcare.,10189951;,"RYAN, ANDREW M;","ANDERSON, KAY ",07/01/2010,04/30/2015,,Estimating Hospital Outcome Quality: Applications to Pay-for-Performance,18546,HCRT,HSR Health Care Research Training SS,,,6,, 8926208,R01,AA,7,N,11/17/2014,11/17/2014,05/31/2015,273,R01AA022583,SCHOOLS OF MEDICINE,PA-14-078,7R01AA022583-03,NIAAA:306520\,Research Projects,2014,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,SAN FRANCISCO,UNITED STATES,NEUROLOGY,12,,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"PUBLIC HEALTH RELEVANCE: Neuroactive drugs are among our most powerful tools for understanding the nervous system and treating psychiatric disease. Behavior-modifying compounds have revolutionized neuroscience research and the treatment of anxiety disorders. Most neuroactive drugs were discovered via unexpected behavioral phenotypes. However, technologies for systematic behavior based screening for chemical modifiers of startle and anxiety- related behaviors have not been possible. Here, we combine high-throughput chemical screening strategies with complex behavioral phenotyping to identify novel startle modifying compounds. These efforts may improve our understanding of the brain and accelerate the pace of neuroactive drug discovery.",10227806;,"KOKEL, DAVID;","EGLI, MARK ",09/01/2013,05/31/2018,Adult;Affect;Agitation;American;analog;Animal Model;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;Area;Awareness;base;Behavior;Behavioral;Behavioral Model;Benzodiazepines;Biochemical;Biological Assay;Biological Models;Biology;Brain;cellular targeting;Chemical Modifier;Chemicals;Complex;cost effective;desensitization;drug discovery;gamma-Aminobutyric Acid;Gene-Modified;Generalized Anxiety Disorder;Genes;Genetic;genetic profiling;Genome;genome-wide;Genotype;Goals;Health;high throughput screening;Human;Hypesthesia;improved;In Vitro;in vitro Assay;in vivo;Individual;Life;Ligands;Mammals;Medicine;meetings;Mental Depression;Mental disorders;Modeling;Molecular;Molecular Target;Moods;Mus;nervous system disorder;Nervous system structure;Neurons;Neurosciences;Neurosciences Research;novel;novel strategies;novel therapeutics;Panic Disorder;Pathway interactions;Pharmaceutical Preparations;Pharmacogenetics;Pharmacology;Phenotype;Post-Traumatic Stress Disorders;prototype;Research;response;screening;Side;Signal Pathway;Signal Transduction;small molecule;small molecule libraries;success;Swimming;Systems Biology;Technology;Therapeutic;tool;Vertebrates;Work;Zebrafish,Behavior-based chemical screening for GABAergic and startle modifying drugs,22583,ZRG1,Special Emphasis Panel,,,3,306520, 8924732,R01,AR,7,N,11/20/2014,10/01/2014,04/30/2015,846,R01AR065083,,PA-14-078,7R01AR065083-02,NIAMS:332344\,Research Projects,2014,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,LA JOLLA,UNITED STATES,,49,,US,SANFORD-BURNHAM MEDICAL RESEARCH INSTIT,CA,920371005,"PUBLIC HEALTH RELEVANCE: Muscle maintenance and regeneration requires the proper activation, proliferation and differentiation (myogenesis) of muscle stem cells known as satellite cells. A decrease in the number and myogenic activity of satellite cells contributes to the development of several muscle dystrophies and is associated with the gradual loss of skeletal muscle mass associated with aging (sarcopenia). Our objective is to establish the molecular mechanisms through which the nucleoporin Nup210 regulates myogenesis and define its function in muscle formation and maintenance, with the ultimate goal of uncovering its role in muscle regeneration. Our findings may enable the design of novel therapeutic strategies for the treatment of muscle injury and myopathies.",10421489;,"D'ANGELO, MAXIMILIANO A.;","BOYCE, AMANDA T.",10/01/2014,04/30/2019,,Mechanisms of Nup210 Regulation of Muscle Development and Regeneration,65083,NCSD,Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section,,,2,332344, 8915298,R01,CA,7,N,11/21/2014,05/31/2014,04/30/2015,396,R01CA149258,SCHOOLS OF MEDICINE,PAS-08-048,7R01CA149258-06,NCI:301150\,Research Projects,2014,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,NEUROLOGY,03,,US,YALE UNIVERSITY,CT,065103209,"Prospects for better efficacy of glioma treatment protocols hinge on the successful unraveling of molecular pathways that control the aberrant invasion and recurrence of glioma tumors. Our experiments are designed to identity a novel molecular element that aids glioma invasion and growth, and understand the molecular basis of its function. Successful completion of this study will establish the proof-of-concept for rational therapeutic targeting of a novel, pharmacologically tractable, drug discovery target to specifically counter glioma tumor spread and growth.",9825696;,"GHOSH, SOURAV;","WOODHOUSE, ELIZABETH ",07/01/2010,04/30/2015,Adjuvant;Apical;base;Biological Assay;Brain;Brain Neoplasms;brain tissue;cell growth;cell motility;Cell Proliferation;Cell Separation;Cell-Cell Adhesion;Cells;Cessation of life;Characteristics;chemotherapy;Child;Clinical;Clinical Management;Clinical Treatment;Complement;Data;Defect;design;Development;Diagnosis;Disease;Drug Design;drug discovery;Elements;Embryo;Epidermal Growth Factor Receptor;Excision;Exhibits;Genes;Glioblastoma;Glioma;glioma cell line;Gliomagenesis;Goals;Growth;Hour;Immunocompromised Host;implantation;improved;In Vitro;in vivo;Indium;innovation;Invaded;Lateral;Lead;Light;Malignant Childhood Neoplasm;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;migration;Mitosis;Modeling;Molecular;Molecular Target;Mortality Vital Statistics;Mus;Nature;neoplastic cell;nerve stem cell;Neuraxis;NIH Program Announcements;novel;novel strategies;novel therapeutics;Oncogenic;Operative Surgical Procedures;Outcome;outcome forecast;Pathology;Pathway interactions;Patients;Play;pre-clinical;prevent;Primary Neoplasm;Property;Radiation therapy;Recurrence;Regimen;Relapse;research study;Resistance;Role;Seeds;self-renewal;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Slice;Solid Neoplasm;stem;stem cell population;Stem cells;subcutaneous;Survival Rate;System;Testing;Therapeutic;therapeutic target;Treatment Protocols;tumor;Tumor Cell Invasion;tumor growth;Tumor-Derived;Undifferentiated;United States;Vertebral column;white matter;Xenograft Model;Xenograft procedure,Apical-basal polarity signaling in glioblastoma,149258,TPM,Tumor Progression and Metastasis Study Section,,,6,301150, 8956769,R01,GM,7,N,11/20/2014,06/01/2014,01/31/2015,859,R01GM071630,SCHOOLS OF PHARMACY,PA-10-067,7R01GM071630-12,NIGMS:224099\,Research Projects,2014,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,PHARMACOLOGY,12,,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"The physical chemistry of drugs greatly influences their biology. A largely unexplored aspect of this is the propensity of many drugs and reagents to form colloids at relevant concentrations, which wholly changes their properties. Here we explore the impact of their colloids on the behavior of drugs in biological environments, including in vivo This could have a profound effect on drug discovery.",2081368;,"SHOICHET, BRIAN K.;","FABIAN, MILES ",08/01/2004,01/31/2016,Address;Adsorption;Affect;analog;Animals;aqueous;Attention;Automobile Driving;base;Behavior;Biochemical;Biological;Biological Assay;Biology;Buffers;Cell Culture Techniques;Cells;Characteristics;Chemicals;Collaborations;Colloids;driving force;drug discovery;Drug Kinetics;Environment;Enzymes;Fulvestrant;G Protein-Coupled Receptor Signaling;Goals;in vivo;inhibitor/antagonist;Intestines;Investigation;Kinetics;Lead;Left;Liquid substance;Membrane;Modeling;Morphologic artifacts;neoplastic;Online Systems;Oral;Penetration;Pharmaceutical Preparations;Physical Chemistry;Play;Property;Proteins;Radial;Rattus;Reagent;receptor;receptor binding;Role;rottlerin;Route;screening;Serum;Simulate;small molecule;Solutions;Specificity;Structure;sup35;Surface;targeted delivery;Techniques;Thermodynamics;Time;tissue/cell culture;Tissues;tool;tool development;tumor;Vascular Permeabilities;Work;Yeasts,A Specific Mechanism for Non-Specific Inhibition,71630,SBCA,Synthetic and Biological Chemistry A Study Section,,,12,224099, 8939154,R01,HL,7,N,11/17/2014,11/18/2014,05/31/2015,837,R01HL094499,SCHOOLS OF MEDICINE,PA-07-070,7R01HL094499-06,NHLBI:139532\,Research Projects,2014,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,,US,UNIVERSITY OF PENNSYLVANIA,PA,191046205,"PUBLIC HEALTH RELEVANCE: Occlusion of blood vessels in the heart, brain, or limbs is a leading cause of death worldwide. The creation of new blood vessels in response to such events can be critical to tissue function and survival. We have uncovered a novel pathway that regulates the formation of new blood vessels. We propose here to examine this new pathway in close detail. These investigations may set the stage for the development of new classes of therapeutic drugs for ischemic diseases, as well as other diseases in which the formation of new blood vessels can be critical.",1892461;,"ARANY, ZOLTAN P;","GAO, YUNLING ",06/01/2010,05/31/2015,adenylate kinase;Adult;Alleles;angiogenesis;Animals;Blood flow;blood vessel occlusion;Blood Vessels;Brain;Cause of Death;Cell Culture Techniques;Cell model;Cell Respiration;Cells;Cessation of life;Consumption;Data;density;deprivation;Development;Disease;Elements;Employee Strikes;Endothelial Cells;Endothelium;Event;Failure (biologic function);femoral artery;Gene Transfer Techniques;Genetic;Goals;Health;Heart;Hindlimb;Homeostasis;in vivo;Injury;Investigation;Ischemia;kinase inhibitor;Ligation;Limb structure;Link;MAP Kinase Gene;Mediating;Mediator of activation protein;Metabolic;Metabolism;Mitochondria;mitogen-activated protein kinase p38;Modeling;Molecular;Molecular Genetics;Morbidity - disease rate;Mortality Vital Statistics;mouse model;Mus;Muscle;Muscle Fibers;Myocardial Ischemia;neovascularization;new therapeutic target;novel;Nuclear Orphan Receptor;Nutrient;Organ;Oxygen;Pathway interactions;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;prevent;programs;Promotor (Genetics);Proteins;reconstitution;Recovery;Relative (related person);response;Role;Signal Transduction;Skeletal muscle structure;Staging;Testing;Therapeutic;Tissues;Transcription Coactivator;transcription factor;Vascular Endothelial Growth Factor Receptor;Vascular Endothelial Growth Factors;Withdrawal,PGC-1 Coactivators in Muscle Angiogenesis Ischemia,94499,VCMB,Vascular Cell and Molecular Biology Study Section,,,6,139532, 8921501,R01,MH,7,N,11/19/2014,09/05/2014,04/30/2015,242,R01MH094241,,PA-14-078,7R01MH094241-04,NIMH:341894\,Research Projects,2014,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHAMPAIGN,UNITED STATES,,13,,US,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,IL,618207406,"When current interventions are designed without an understanding of how to optimally mesh behavior recommendations, a theory and evidence-based-intervention principles are likely to catalyze a transformation. Specifically, researching this strikingly uncharted territory has the promise to revolutionize behavioral treatment of HIV as well as other diseases from cancer to cardiovascular disease to diabetes.",2097462;,"ALBARRACIN, DOLORES;","GORDON, CHRISTOPHER M.",07/10/2012,04/30/2017,Accounting;Acquired Immunodeficiency Syndrome;Address;Adherence (attribute);AIDS prevention;Alcohol abuse;alcohol behavior;Alcohol consumption;Alcohols;Anti-Retroviral Agents;Area;base;Behavior;behavior change;behavior influence;Behavior Therapy;Behavioral;behavioral health;biobehavior;Body Weight decreased;cancer risk;Cardiovascular Diseases;Clinical;Code;combinatorial;comparative effectiveness;comparative efficacy;Complex;condoms;cost;Data;Decision Trees;design;Developed Countries;Developing Countries;Diabetes Mellitus;Diet;diet and exercise;Diet Habits;Disease;disorder risk;Drug usage;economic outcome;Effectiveness;effectiveness research;Ethnicity aspects;Evidence based intervention;Exercise;Fatty acid glycerol esters;Funding;Future;Gender;Genetic Predisposition to Disease;Geographic Locations;good diet;Government Agencies;Health;Health behavior;Health Promotion;Healthcare;HIV;Human;improved;infancy;Infection;Injection of therapeutic agent;innovation;Intake;Intervention;Investments;Knowledge;Life;Life Style;lifestyle intervention;Literature;Malignant Neoplasms;Medical;medication compliance;Mental disorders;Meta-Analysis;Methadone;Methods;Modeling;Morbidity - disease rate;Mortality Vital Statistics;Outcome;Paper;Pattern;Persons;Pharmaceutical Preparations;Population;Population Study;Prevalence;Prevention;psychologic;Publishing;Race;Randomized Controlled Trials;Recommendation;reduced alcohol use;Regimen;Reporting;Request for Applications;Research;Research Personnel;Risk Behaviors;Risk Factors;Science;Scientific Societies;Series;sex;Sexually Transmitted Diseases;Smoking;Specific qualifier value;Statistical Methods;stem;Structure;success;Suggestion;symposium;System;Techniques;Technology;Testing;theories;therapy design;Time;web site,Efficacy and Effectiveness of Multi-Behavior Interventions Relevant to HIV,94241,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,,4,341894, 8956637,R01,NS,7,N,11/19/2014,07/01/2014,01/31/2015,853,R01NS055140,SCHOOLS OF MEDICINE,PA-10-067,7R01NS055140-08,NINDS:201687\,Research Projects,2014,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,NEUROSURGERY,12,,US,"UNIVERSITY OF CALIFORNIA, SAN FRANCISCO",CA,941430962,"PUBLIC HEALTH RELEVANCE: Our long term goal is to develop effective immunotherapy strategies for brain tumors. We have translated our past preclinical findings into early clinical trials that demonstrated safety and immunological activities. The currently proposed preclinical study will evaluate an entirely novel immunotherapy approach with engineering of microRNAs in anti-tumor T cells, which we hope to translate into clinical trials in near future.",6660951;,"OKADA, HIDEHO;","FOUNTAIN, JANE W.",04/01/2006,01/31/2016,Address;Adoptive Cell Transfers;Adoptive Transfer;Autoimmunity;Brain Neoplasms;cancer immunotherapy;Cell Death;Cell physiology;Cell Proliferation;Cell Survival;Cells;cellular engineering;Central Nervous System Neoplasms;chemokine;chemotherapy;Clinical Trials;CXCL10 gene;cytotoxic;Cytotoxic T-Lymphocytes;Data;Development;Dose;Down-Regulation;Engineering;Funding;Future;Genetic Engineering;Glioma;Goals;Health;Immune response;Immunity;immunogenicity;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Integrins;Interferons;Interleukin-4;Intravenous;Lymphocyte Function;Lymphoproliferative Disorders;Malignant Neoplasms;Mediating;MicroRNAs;Mus;novel;Oncogenic;overexpression;Pathway interactions;Patients;Phase;Phenotype;pre-clinical;preclinical study;Production;receptor;Resistance;response;Safety;Signal Transduction;Site;STAT6 Transcription Factor;stem;T cell response;T memory cell;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Transforming Growth Factors;Transgenes;Transgenic Mice;Transgenic Organisms;Translating;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-Derived;Vaccination;Wild Type Mouse;Work,Novel Immunotherapy of Glioma using miR-17-92 Transfected T Cells,55140,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,,8,201687, 8954412,R01,NS,7,N,11/17/2014,06/17/2014,01/31/2015,853,R01NS081141,SCHOOLS OF MEDICINE,PAR-13-048,7R01NS081141-02,NINDS:315420\,Research Projects,2015,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,RIVERSIDE,UNITED STATES,NONE,41,,US,UNIVERSITY OF CALIFORNIA RIVERSIDE,CA,925210001,"PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because we are identifying and assessing the mechanism of action of a putative therapeutic agent that stimulates endogenous myelination resulting in sparing of axons and clinical protection during demyelinating diseases. The proposed research is relevant to the part of NIH's mission that pertains to the conceptualization, discovery, and preclinical evaluation of innovative therapeutics for nervous system disorders, with the goal of accelerating the development of new treatments for these diseases that will help to reduce the burdens of human disability.",1874654;,"TIWARI-WOODRUFF, SEEMA K.;","UTZ, URSULA ",02/01/2014,01/31/2018,Adverse effects;Affect;Affinity;Anti-Inflammatory Agents;antibody conjugate;Axon;axonal degeneration;base;Behavioral;Cell Differentiation process;Cells;Clinical;Collaborations;Corpus Callosum;Cuprizone;cytokine;Data;Demyelinating Diseases;Demyelinations;Development;diarylpropionitrile;Diet;disability;Disease;Disease Progression;Dose;Electron Microscopy;Electrophysiology (science);enhanced green fluorescent protein;Estradiol;Estrogen Receptor beta;Estrogen Receptor Modulators;Estrogen Receptors;Experimental Autoimmune Encephalomyelitis;Failure (biologic function);Fluorescence;Gene Proteins;Generic Drugs;Goals;Growth Factor Receptors;Health;Human;Hydrophobicity;Immunohistochemistry;improved;in vivo;Indazoles;Inflammation;innovation;insight;Insulin;Knockout Mice;Lesion;Ligands;material transfer agreement;Microspheres;Mission;Modeling;mouse model;mTOR Signaling Pathway;Multiple Sclerosis;Mus;Myelin;myelination;Nature;Nerve Degeneration;nervous system disorder;neuroprotection;Neuroprotective Agents;Oligodendroglia;Pathogenesis;Patients;Pharmaceutical Preparations;Phase;preclinical evaluation;prevent;Protein Analysis;Proteolipids;public health medicine (field);Publishing;Recovery of Function;remyelination;Research;research study;Risk;Role;Safety;screening;Signal Pathway;Signal Transduction Pathway;Signaling Molecule;Simulate;Sorting - Cell Movement;Specificity;Staging;Stem cells;Symptoms;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Transgenic Organisms,Stimulating oligodendrocyte progenitor cell differentiation and remyelination,81141,DDNS,,,,2,315420, 8960423,R03,DA,7,N,11/18/2014,09/01/2014,05/31/2015,279,R03DA036683,,PA-12-129,7R03DA036683-02,NIDA:77031\,Research Projects,2014,NATIONAL INSTITUTE ON DRUG ABUSE,,BOSTON,UNITED STATES,,07,,US,TUFTS MEDICAL CENTER,MA,021111526,"PUBLIC HEALTH RELEVANCE: The proposed research will provide a proof of principle for computer-based versions of the SOAPP-R, a screener that predicts risk of opioid abuse. The computer-based versions use information from a respondent's answers to customize the screener to the individual taking it. Computer-based instruments have the potential to reduce respondent burden, thereby making the screener more accessible to compromised populations and aiding clinicians in their decision of whether to prescribe opioids. ",9713032;,"FINKELMAN, MATTHEW;","DUFFY, SARAH Q",06/16/2014,05/31/2016,base;Behavior;Chronic;Classification;clinically significant;Computer Assisted;computer code;Computer Programs and Programming;Computer software;Computers;Data;Data Set;Decision Trees;design;Development;Evaluation;Exhibits;follow-up;Goals;Gold;Health;improved;indexing;Individual;instrument;Interview;Length;Measurement;Measures;Methods;non-cancer pain;Opioid;opioid abuse;Pain;Paper;Patient Self-Report;Patients;Pharmaceutical Preparations;Phase;physical conditioning;Physicians;Population;Predictive Value;Procedures;programs;prototype;Provider;public health relevance;Questionnaire Designs;Questionnaires;reading comprehension;reading difficulties;Recommendation;Relative (related person);Reporting;Research;Research Infrastructure;Respondent;response;Risk;Risk Assessment;Sampling;Sensitivity and Specificity;standard measure;statistics;Structure;Testing;Time;Toxicology;Training;Urine;Work;Writing,Shortening the SOAPP-R: Computer-based opioid risk assessment,36683,HSOD,Health Services Organization and Delivery Study Section,,,2,77031, 8877979,R15,GM,7,N,11/19/2014,08/01/2014,05/31/2015,859,R15GM090167,,PA-14-078,7R15GM090167-02,NIGMS:28865\,Research Projects,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WORCESTER,UNITED STATES,,02,,US,"CLARK UNIVERSITY (WORCESTER, MA)",MA,016101400,"Project Narrative The issue of gene regulation is at the heart of our understanding of development and disease. Carefully timed and spatially controlled expression of key developmental genes, many of which are transcription factors that regulate the expression of downstream genes, serves as the critical basis for normal development. The early patterns of Hox gene expression in the embryo initiate a cascade of regulatory events at the molecular level that has profound consequences for later development. Currently our understanding of the mechanisms of cis-regulation for the Hox genes is still very superficial. Our preliminary studies have led us to investigate the function of cis-regulatory modules and how transcription factors act at the regulatory sequence level to control the expression of Hox genes at the Drosophila bithorax complex. The conservation of many of these key developmental genes and mechanisms of gene regulation across all animals promises that these studies will be informative for studies in organisms beyond Drosophila.",8246258;,"DREWELL, ROBERT A;","HOODBHOY, TANYA ",06/01/2010,05/31/2015,,Molecular Dissection of Drosophila Hox Gene Cis-Regulatory Modules,90167,DEV1,Development - 1 Study Section,,,2,28865,