APPLICATION_ID,ACTIVITY,ADMINISTERING_IC,APPLICATION_TYPE,ARRA_FUNDED,AWARD_NOTICE_DATE,BUDGET_START,BUDGET_END,CFDA_CODE,CORE_PROJECT_NUM,ED_INST_TYPE,FOA_NUMBER,FULL_PROJECT_NUM,FUNDING_ICs,FUNDING_MECHANISM,FY,IC_NAME,NIH_SPENDING_CATS,ORG_CITY,ORG_COUNTRY,ORG_DEPT,ORG_DISTRICT,ORG_DUNS,ORG_FIPS,ORG_IPF_CODE,ORG_NAME,ORG_STATE,ORG_ZIPCODE,PHR,PI_IDS,PI_NAMEs,PROGRAM_OFFICER_NAME,PROJECT_START,PROJECT_END,PROJECT_TERMS,PROJECT_TITLE,SERIAL_NUMBER,STUDY_SECTION,STUDY_SECTION_NAME,SUBPROJECT_ID,SUFFIX,SUPPORT_YEAR,DIRECT_COST_AMT,INDIRECT_COST_AMT,TOTAL_COST,TOTAL_COST_SUB_PROJECT
9321361,U19,AI,5,N,7/20/2017,8/1/2017,7/31/2018,,U19AI067773,,RFA-AI-14-055,5U19AI067773-13,NIAID:107745\,Non-SBIR/STTR RPGs,2017,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,13,621889815,US,1833205,COLUMBIA UNIVERSITY HEALTH SCIENCES,NY,100323702,,1925384; ,"BITTNER, MICHAEL L.;",,,,base; biodosimetry; Bioinformatics; Biological; Biological Assay; Biological Markers; biomarker discovery; Biometry; biophysical model; Biostatistics Core; Blood Volume; Cell Count; Cells; Classification; Common Core; Complex; Computer software; Data; Data Analyses; Data Set; Dependence; Development; Dose; Dose-Rate; experience; Experimental Designs; Genes; genomic biomarker; Genomics; Goals; high dimensionality; Imagery; improved; Individual; Informatics; Injury; innovation; insight; Joints; Link; Measurement; metabolomics; Methodology; Methods; minimally invasive; Mission; Modeling; Mus; Pathway Analysis; Pathway interactions; Pattern; Play; predictive marker; programs; Radiation; Research Personnel; response; Sample Size; Sampling; sharing data; software development; Software Tools; Statistical Data Interpretation; Statistical Models; Supervision; synergism; Techniques; Testing; Time; tool; transcriptomics; trend; Work; ,Informatics and Biostatistics Core,67773,ZAI1,Special Emphasis Panel ,6139,,13,145506,0,,107745
9333116,I21,VA,5,N,10/18/2017,10/1/2017,9/30/2018,999,I21RX002238,,RFA-RX-16-011,5I21RX002238-02,,RESEARCH CENTERS,2018,Veterans Affairs,,DECATUR,UNITED STATES,,4,824835805,US,481023,VETERANS HEALTH ADMINISTRATION,GA,300334004,"Our aging veteran population will substantially increase over the next 10 years, as the 24.9% of veterans who are currently between 55-64 years of age join the 38.5% who are already over age 65. The risk of stroke more than doubles each decade after age 55, which places our veterans at an ever-increasing risk of suffering stroke-related language impairment (i.e., aphasia). Difficulty retrieving words, which negatively impacts psychosocial well-being and quality of life, is the most common complaint in healthy aging and aphasia. Word retrieval interventions to maintain or restore communicative function are needed. Studies have shown that physical exercise can improve word learning in young adults. This study will investigate the effects of exercise on word learning in aging and aphasia. The results will help us understand how exercise may be used to optimize word retrieval interventions for our aging veterans.",10589221; ,"RODRIGUEZ, AMY ;",,10/1/2016,9/30/2018,Acute; Address; Adult; Aerobic Exercise; Age; Age-associated memory impairment; Age-Years; Aging; Analysis of Covariance; Analysis of Variance; Animals; Anticoagulants; Aphasia; base; Behavioral; Blood; Blood specimen; Brain; Brain-Derived Neurotrophic Factor; Cognitive; Crossover Design; disability; Disease; Dopamine; Elderly; emerging adult; Enzyme-Linked Immunosorbent Assay; Exercise; exercise intensity; Feedback; Future; Goals; healthy aging; Hippocampus (Brain); Human; Immediate Recalls; improved; Individual; Intervention; Investigation; Language; language impairment; Learning; Levodopa; Literature; long term memory; Lower Extremity; male; Measures; Mediating; Mediator of activation protein; Memory; Methods; Modeling; Names; neurophysiology; Neuropsychology; neuroregulation; novel; Outcome; Performance; Physical assessment; Physical Exercise; Plasma; Population; psychologic; psychosocial; Quality of life; Recruitment Activity; Research; Rest; Retrieval; Risk; Sampling; Serum; Short-Term Memory; Stretching; stroke; Testing; Time; Training; translational research program; Tube; Upper Extremity; Verbal Learning; Veterans; Whole Blood; word learning; young adult; ,Acute Exercise Effects on Word Learning in Aging and Stroke-induced Aphasia,2238,RRDS,Rehabilitation Research and Development SPiRE Program ,,,2,,,,
9397977,I01,VA,5,N,10/16/2017,10/1/2017,9/30/2018,999,I01RX001821,,RFA-RX-15-003,5I01RX001821-03,,Non-SBIR/STTR RPGs,2017,Veterans Affairs,,IOWA CITY,UNITED STATES,,2,28084333,US,481031,IOWA CITY VA MEDICAL CENTER,IA,522462209,"PUBLIC HEALTH RELEVANCE:     Testing the full visual field in a more accurate, precise and efficient way will lead to 1) earlier diagnosis and 2) earlier detection of visual field change allowing more timely intervention; 3) a more comprehensive evaluation of functional vision and 4) better correlation of change in optic nerve structural damage with visual field performance. In addition, with cases of moderate to severe visual loss, evaluation of the full visual field with an almost a doubling of the useful dynamic range will provide a larger area to monitor for changes in vision. This will make possible an improved and more comprehensive assessment of functional vision for veterans with glaucoma and other optic nerve diseases and improved outcome measures for VA rehabilitation research protocols.",9417387; ,"WALL, MICHAEL ;",,10/1/2015,9/30/2019,advanced disease; Agreement; Algorithms; Area; base; Blindness; central visual field; clinical practice; computerized; Coupled; Data; Defect; Disease; Disease Outcome; Early Diagnosis; Early Intervention; Environment; Evaluation; Evolution; Eye; field study; Frequencies; Glaucoma; Hour; improved; improved outcome; Intervention; Investigation; Kinetics; Knowledge; Location; Manuals; Methodology; Methods; Monitor; Octopus; Optic Nerve; optic nerve disorder; Optical Coherence Tomography; Outcome Measure; Papilledema; Patients; Pattern; Performance; Perimetry; Peripheral; Physiologic Intraocular Pressure; Positioning Attribute; Process; Protocols documentation; Pseudotumor Cerebri; public health relevance; Rehabilitation Research; Research; research clinical testing; retinal nerve fiber layer; Running; Scotoma; Site; Stimulus; Structure; Suspect Glaucomas; Techniques; Test Result; Testing; Time; United States National Institutes of Health; Veterans; Vision; Visual; Visual Fields; ,Testing of the Peripheral Visual Field - Obtaining the Full View,1821,RRD3,Sensory Systems/Communication Disorders ,,,3,,,,
9453509,F32,MH,1,N,9/13/2017,9/13/2017,9/12/2018,242,F32MH115419,SCHOOLS OF MEDICINE,RFA-MH-17-250,1F32MH115419-01,NINDS:62321\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF MENTAL HEALTH,,CLEVELAND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,11,135781701,US,10000858,CLEVELAND CLINIC LERNER COM-CWRU,OH,441950001,"PROJECT NARRATIVE As researchers investigate new clinical applications of implanted neurological devices, ongoing ethical oversight is needed to ensure human brain research is conducted according to the highest ethical standards. This project seeks to characterize ethical concerns arising when study participants exit or withdraw from clinical trials and face decisions about the surgical removal of implanted neurotechnology. This research will support the development of evidence- based ethical safeguards to ensure the public health benefits of neurotechnology research are consistent with the health and safety of human research participants.",14902722; ,"SANKARY, LAUREN ;","DESMOND, NANCY L",9/13/2017,9/12/2020,Address; BRAIN initiative; brain research; chronic pain; clinical application; Clinical Trials; Complex; Consent; Data; Deep Brain Stimulation; Development; Device Removal; Devices; Emotional; Empirical Research; Ensure; Ethical Analysis; Ethics; Evaluation; evidence base; evidence based guidelines; Excision; expectation; experience; Exposure to; Face; Funding; Goals; Guidelines; Health; Health Benefit; Human; Implant; implantable device; Informed Consent; innovation; Interview; Investigation; Laws; Legal; Medicine; Mental Depression; Mental disorders; Methodology; Motivation; Nervous System Physiology; Neurologic; neurotechnology; novel; Obsessive-Compulsive Disorder; Participant; Policy Analysis; Procedures; Process; prospective; Protocols documentation; Public Health; Publishing; Qualitative Research; Recruitment Activity; Regulation; Research; Research Methodology; Research Personnel; Research Project Summaries; research study; Research Subjects; Risk; risk minimization; Safety; skills; Source; stroke treatment; Structure; systematic review; Training; Withdrawal; ,Ethical Safeguards for Exit and Withdrawal from Implanted Neurotechnology Research,115419,ZMH1,Special Emphasis Panel ,,,1,62321,,62321,
9468753,F32,GM,1,N,9/15/2017,9/26/2017,9/25/2018,859,F32GM126644,SCHOOLS OF ARTS AND SCIENCES,PA-16-307,1F32GM126644-01,NIGMS:56334\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PASADENA,UNITED STATES,NONE,29,9584210,US,1073501,CALIFORNIA INSTITUTE OF TECHNOLOGY,CA,911250001,"Project Narrative Achieving tunable, catalyst-controlled selectivity for C?H functionalization is a remaining grand challenge in the synthesis and diversification of bioactive molecules. Preliminary results from the Gray Laboratory show an earth- abundant water oxidation catalyst to be capable of oxidizing C?H bonds with switchably selectivity based on applied potential. We propose to collaboratively develop this chemistry into a broadly-useful method for tunably functionalizing C?H bonds, providing a means to streamline the synthesis of bioactive molecules and solving this longstanding problem in synthetic chemistry.",14947804; ,"WEST, JULIAN G;","LEES, ROBERT G",9/26/2017,9/25/2020,base; Biological; catalyst; Chemistry; Complex; Data; design; Development; Electrochemistry; Elements; Enzymes; Event; experience; flexibility; Fluorine; functional outcomes; Future; Glean; Gray unit of radiation dose; Health; Human; Hydrocarbons; Hydrogen; Hydrogen Bonding; improved; In Situ; Inorganic Chemistry; insight; interest; Investigation; Iron; Laboratories; Libraries; Methods; Nature; Nickel; Oxidases; oxidation; Oxides; Pharmacologic Substance; Planet Earth; Process; Property; Reaction; scaffold; Scheme; Shunt Device; Side; single molecule; Site; small molecule; Specificity; Spectrum Analysis; Synthesis Chemistry; System; Techniques; Training; Water; ,Selective C?H Functionalization of Bioactive Molecules Via Tunable Electrocatalysis,126644,ZRG1,Special Emphasis Panel ,,,1,56334,,56334,
9469872,F31,MH,1,N,9/15/2017,9/29/2017,9/28/2018,242,F31MH115656,SCHOOLS OF MEDICINE,PA-16-309,1F31MH115656-01,NIMH:42444\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,PSYCHIATRY,13,78861598,US,3839801,ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI,NY,100296574,"Project Narrative  Fragile X Syndrome (FXS) is the most common inherited monogenic cause of autism spectrum disorder (ASD) or intellectual disability (ID) with no pharmacological treatment currently available. This proposal will explore the role of Fragile X Mental Retardation Protein (FMRP), which is lost in FXS, in prefrontal cortex (PFC) neural activity and neuroanatomy underlying attentional functioning, which are impaired in FXS. The proposed studies will provide a better understanding of the mechanism underlying impaired attention in FXS and inform more effective therapeutic strategies for individuals with FXS. !",14315342; ,"GOLDEN, CARLA ;","VAN'T VEER, ASHLEE V",9/29/2017,9/28/2020,Address; Affect; Anatomy; Animal Model; Anterior; Attention; Attentional deficit; autism spectrum disorder; Behavior; Behavioral; behavioral impairment; Biological Models; Brain; career; Cellular Morphology; cingulate cortex; Clinical Trials; Cognition; Cognitive; Complex; Cytoskeleton; Data; Dendritic Spines; Diffusion Magnetic Resonance Imaging; Dose; Electroencephalography; Electrophysiology (science); executive function; Exhibits; Fellowship; Female; FMR1; Fragile X Syndrome; Functional disorder; Future; Goals; gray matter; Human; Image; Impaired cognition; Impairment; improved; in vivo; inattention; Individual; Inherited; insight; Intellectual functioning disability; Intervention; Knock-out; Knockout Mice; Lead; Learning; Link; Magnetic Resonance Imaging; male; Measures; Messenger RNA; Modeling; Morphology; mouse model; Mus; neural circuit; neural correlate; Neuroanatomy; Neurobiology; neuronal circuitry; Neurons; Outcome; Patients; Performance; Pharmacological Treatment; Pharmacology; Phenotype; Physiological; Play; Polyribosomes; postsynaptic; Prefrontal Cortex; Prevalence; Proteins; Rattus; Reaction Time; relating to nervous system; Research; Ribosomes; Role; sex; Sex Characteristics; sustained attention; Synapses; Testing; therapy development; Training; Treatment Efficacy; Visuospatial; white matter; ,Underlying neuronal circuitry of attention in both sexes of a rat model of Fragile X Syndrome,115656,ZRG1,Special Emphasis Panel ,,,1,42444,,42444,
9471727,I01,VA,5,N,10/17/2017,6/1/2017,5/31/2018,999,I01RX001334,,RFA-RX-13-001,5I01RX001334-04,,Non-SBIR/STTR RPGs,2018,Veterans Affairs,,CLEVELAND,UNITED STATES,,14,93016124,US,481118,LOUIS STOKES CLEVELAND VA MEDICAL CENTER,OH,441413204,"PUBLIC HEALTH RELEVANCE:            Upper limb amputation is a significant non-fatal co-morbidity of combat operations and one of the more prevalent disabilities among veterans. Unfortunately, available prosthetic options, especially for upper limb loss do not offer the veteran the quality of life they deserve after thei sacrifice in service for our country. Upper limb prostheses have undergone a significant revolution in their mechatronics over the past decade, but the inclusion of natural sensory feedback has lagged due to the limited availability of reliable neural interfaces. This project provides natural sensory feedback to veteran and general amputee limb loss patients and is highly relevant as it employs technologies that can be generally available within the next four to eight years.",1926275; ,"TYLER, DUSTIN J.;",,6/1/2014,5/31/2018,Address; Amputees; Attention; Beauty; Chronic; Clinic; Clinical; cognitive load; cohort; Collaborations; combat; Communities; Comorbidity; Complex; Conscious; Country; demographics; design; Development; Devices; disability; Electrodes; Elements; Environment; Esthesia; Eye; functional improvement; Funding; Future; Hand; Home environment; Implant; implantable device; improved; Institutional Review Boards; Investigation; Investments; limb amputation; Limb Prosthesis; Limb structure; Liquid substance; Location; Longitudinal Studies; Mechanics; Motion; Movement; Nerve; operation; Patients; Pattern; Perception; Performance; Peripheral; Peripheral Nerve Stimulation; Peripheral Nerves; Persons; Phantom Limb; Population; premature; pressure; Proprioception; Prosthesis; prosthesis control; prosthesis wearer; prototype; public health relevance; Quality of life; relating to nervous system; Research; Residual state; restoration; Sculpture; Sensory; sensory feedback; Services; Solid; Stimulus; System; Technology; Time; Upper Extremity; Variant; Veterans; vibration; Visual; Visual attention; Work; Wrist; ,Peripheral Interfaces in Amputees to Restore Sensation,1334,RRD5,Rehabilitation Engineering & Prosthetics/Orthotics  ,,,4,,,,
9550859,I21,VA,5,N,10/18/2017,10/1/2017,5/31/2018,999,I21RX001607,,RFA-RX-13-011,5I21RX001607-04,,RESEARCH CENTERS,2018,Veterans Affairs,,PALO ALTO,UNITED STATES,,18,46017455,US,481014,VETERANS ADMIN PALO ALTO HEALTH CARE SYS,CA,943041207,"PUBLIC HEALTH RELEVANCE:           This project is directly relevant to the health care needs of veterans with spinal cord injury. Complications of the neurogenic bladder and bowel are common and costly and greatly impair the quality of life of Veterans. Current management using medications, appliances and surgery does not prevent these complications adequately. The VA has invested in previous research into electrical stimulation with some success, although previous attempts to control the bladder electrically often required cutting of nerves. New discoveries based on animal research in the VA Functional Electrical Stimulation Center that promise to make such cutting of nerves unnecessary are now poised to be translated into human application and have the potential not only to improve health and quality of life but also to reduce costs of care to the Department of Veterans Affairs.",9751665; ,"CREASEY, GRAHAM ;",,10/1/2014,5/31/2018,Address; Animal Experimentation; Animal Experiments; Animals; Ataxia; base; Basic Science; Biomedical Engineering; Bladder; Bladder Control; Cannulas; care systems; Caring; Chronic; Clinical; clinical care; clinical practice; Clinical Research; cost; Decubitus ulcer; design; Development; Disease; Documentation; economic cost; Electric Stimulation; Electrodes; Environment; Evaluation; experience; Feasibility Studies; Frequencies; Goals; Health; Healthcare; Healthcare Systems; Human; human subject; Impaired health; Impairment; Implant; implantation; improved; Incontinence; Indwelling Catheter; Injection of therapeutic agent; innovation; Inpatients; Intestines; Kidney; Knowledge; Laboratories; Left; Life; Measurement; Measures; Metals; minimally invasive; Muscle; muscle form; Muscle Spasticity; Needles; Nerve; Nerve Block; Neurogenic Bladder; Operative Surgical Procedures; Outcome Study; Outpatients; Patients; Pharmaceutical Preparations; Physiologic pulse; Pilot Projects; Preparation; prevent; Probability; public health relevance; Quality of life; Recording of previous events; Recurrence; Research; Research Personnel; Risk; Sphincter; Spinal cord injury; Stents; success; System; Techniques; Testing; Time; Toxin; Training; Translating; Urethra; Urethral sphincter; Urinary tract infection; Urine; Veterans; Work; ,Evaluation of Pudendal Nerve Block for Voiding after Spinal Cord Injury,1607,RRDS,Rehabilitation Research and Development SPiRE Program ,,,4,,,,
9560619,I21,VA,5,N,10/17/2017,6/1/2017,2/28/2018,999,I21RX001925,,RFA-RX-14-009,5I21RX001925-03,,RESEARCH CENTERS,2018,Veterans Affairs,,BRONX,UNITED STATES,,13,40077133,US,481060,JAMES J PETERS VA  MEDICAL CENTER,NY,104683904,"PUBLIC HEALTH RELEVANCE:      Cardiovascular disease-related morbidity in persons with spinal cord injury (SCI) occurs earlier in life, at a greater prevalence than that of the general population, and is the primary cause of death after the first year of injury. During the chronic phase of SCI, a characteristic dyslipidemi emerges, which is characterized by low serum high density lipoprotein cholesterol (HDL-C) concentrations, with values often qualifying to be an independent risk factor for coronary artery disease, and elevations in serum triglycerides (TG). Serum low density lipoprotein cholesterol concentrations in those with SCI are usually similar to those of the general population. The current proposal in persons with SCI aims to determine the safety and efficacy of short-term fenofibrate treatment, an anti-lipid medication whose primary action lowers serum TG and raises serum HDL-C levels.",9724477; ,"LAFOUNTAINE, MICHAEL F;",,6/1/2015,2/28/2018,abdominal fat; Acids; Adverse event; Behavior Therapy; Biological Markers; Blood; Carbohydrates; Cardiac; cardiorespiratory fitness; Cardiovascular Diseases; Caring; Cause of Death; Characteristics; Chronic Phase; Climacteric; Clinical; Clinical Markers; clinical practice; Clinical Practice Guideline; Clinical Trials; cohort; Control Groups; Coronary Arteriosclerosis; Disease; Documentation; drug efficacy; Dyslipidemias; efficacy testing; efficacy trial; epidemiology study; Event; Fenofibrate; Functional disorder; General Population; High Density Lipoprotein Cholesterol; High Density Lipoproteins; Immobilization; improved; Incidence; Individual; Injury; insight; Institutes; Insulin Resistance; Intervention; Investigation; LDL Cholesterol Lipoproteins; Life; Lipids; lipoprotein lipase; Lipoproteins; Low-Density Lipoproteins; meetings; Metabolic; modifiable risk; Monitor; Morbidity - disease rate; mortality; Nature; NMR Spectroscopy; Normal Range; open label; Paralysed; particle; Particle Size; Perceived quality of life; Persons; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacotherapy; Physical activity; Physically Handicapped; Placebos; Plasma; population based; PPAR alpha; Prevalence; public health relevance; Qualifying; Reporting; response; Risk; Risk Factors; Safety; Serum; Spinal cord injury; Therapeutic Effect; TimeLine; treatment duration; Treatment Efficacy; treatment response; Triglycerides; Very low density lipoprotein; Visceral; ,An Open Label Safety and Efficacy Trial of Fenofibrate in Persons with SCI,1925,RRDS,Rehabilitation Research and Development SPiRE Program ,,,3,,,,
9331063,F31,AI,1,N,8/23/2017,9/16/2017,9/15/2018,855,F31AI131595,SCHOOLS OF PUBLIC HEALTH,PA-16-308,1F31AI131595-01,NIAID:42902\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,7,605799469,US,9087701,UNIVERSITY OF WASHINGTON,WA,981959472,"PROJECT NARRATIVE The human microbiome, or the collection of microorganisms that inhabits the human body, has been implicated in a vast range of diseases, and studying the microbiome across time could provide new insights into disease associations. Since statistical methods for longitudinal (time series) microbiome studies are lacking, we will develop new methods to analyze the interrelationship between changing microbial communities and changes in disease state or severity. We will apply these advances to clarify the role of the microbiome in graft-versus- host disease and identify possible therapeutic strategies. !",12115464; ,"PLANTINGA, ANNA ;","ADGER-JOHNSON, DIANE S",9/16/2017,9/15/2019,Address; Aftercare; Area; Automobile Driving; base; Cations; Characteristics; Childhood Asthma; Chronic Obstructive Airway Disease; Collection; Communities; Computing Methodologies; Data; data structure; Detection; Diabetes Mellitus; Disease; Equation; Genes; Graft-vs-Host Disease; Grouping; gut microbiota; Health; Human; Human body; Human Microbiome; Individual; Inflammatory Bowel Diseases; insight; interest; Intuition; longitudinal analysis; Longitudinal Studies; Measurement; Measures; Methodology; Methods; microbial community; microbiome; microorganism; Modeling; Nature; next generation sequencing; novel; Onset of illness; Outcome; Outcome Measure; Phylogenetic Analysis; Play; Population; Psoriasis; Research; Role; Series; Severities; Statistical Methods; Structure; Symptoms; Taxon; Techniques; Technology; Testing; Therapeutic; Time; tool; Transplant Recipients; Work; ,Statistical Methods for Analysis of Longitudinal Microbiome Data,131595,ZRG1,Special Emphasis Panel ,,,1,42902,,42902,
9395961,F31,AA,1,N,9/6/2017,9/15/2017,9/14/2018,273,F31AA025521,SCHOOLS OF ARTS AND SCIENCES,PA-16-309,1F31AA025521-01A1,NIAAA:30367\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,AMHERST,UNITED STATES,PSYCHOLOGY,26,38633251,US,5992614,STATE UNIVERSITY OF NEW YORK AT BUFFALO,NY,14228,"8. PROJECT NARRATIVE  The proposed longitudinal study will enhance our understanding of how social goals and parenting jointly influence adolescent transactions with their peer environment, and facilitate meeting important developmental milestones while also protecting youth from engagement in underage drinking. Identifying how adolescent social goals and parenting styles come together to mitigate risk for alcohol use will help inform intervention efforts that aim to curtail peer influences on adolescent drinking.",14276148; ,"MEISEL, SAMUEL NOAH;","SCOTT, MARCIA S",9/15/2017,9/14/2019,Acute; Address; Adolescence; Adolescent; Affect; affection; Age; Alcohol abuse; Alcohol consumption; alcohol risk; alcohol use disorder; Back; Behavior; Caregivers; Cessation of life; Characteristics; Child; Child Rearing; commune; Communities; Development; DSM-V; Environment; Equilibrium; Etiology; Evolution; Failure; Family; Fostering; Friendships; Goals; Growth; high risk sexual behavior; high standard; illicit drug use; interest; Interpersonal Relations; Intervention; intimate behavior; Joints; Learning; Life; Literature; Longitudinal Studies; Measures; meetings; model development; Modeling; Outcome; Parents; Pattern; peer; peer influence; Personality Character; Play; Prevention; Preventive Intervention; Process; prospective; Public Health; Risk; Risk Behaviors; Role; Sampling; Shapes; social; Social Development; social engagement; Social Environment; Symptoms; Testing; theories; Transact; underage drinking; Work; Youth; ,An Examination of the Joint Effects of Adolescent Social Goals and Parenting Styles on Underage Drinking,25521,ZAA1,Special Emphasis Panel ,,A1,1,30367,,30367,
9470061,F31,GM,1,N,9/7/2017,9/16/2017,9/15/2018,859,F31GM126741,GRADUATE SCHOOLS,PA-16-309,1F31GM126741-01,NIGMS:44044\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,13,49179401,US,1833202,COLUMBIA UNIV NEW YORK MORNINGSIDE,NY,100277922,Multipotent and non-dividing (quiescent) stem cells are critical for normal development but can be very dangerous in cancer. Many cancer therapeutics target actively dividing cells and so identifying therapeutic targets for non-dividing cancer stem cells is critical for more effective anti-cancer therapies. This project investigates pathways involved in the maintenance of long term quiescence.,14964900; ,"O'KEEFFE, CATHERINE ANN;","SLEDJESKI, DARREN D",9/16/2017,9/15/2019,adult stem cell; Alpha Cell; Animals; biological adaptation to stress; Biological Assay; Biosensor; Caenorhabditis elegans; cancer cell; cancer stem cell; cancer therapy; Candidate Disease Gene; Cell Culture Techniques; Cell Cycle; Cell Differentiation process; Cell division; cell type; Cells; chemotherapy; Clinical; Dangerousness; Data; Development; EGF gene; Embryonic Development; Ensure; Epidermal Growth Factor Receptor; Event; experimental study; Feedback; Genetic Screening; Hormones; Human; improved; in vivo; Individual; Insulin; insulin signaling; interest; Interruption; Knowledge; Laboratories; Larva; Learning; Longevity; Maintenance; Malignant Neoplasms; Measures; Mediator of activation protein; MEKKs; Modeling; multipotent cell; mutant; Nematoda; new therapeutic target; notch protein; novel; Nuclear; Organism; Pathway interactions; Phosphorylation; Phosphotransferases; precursor cell; Ras/Raf; Receptor Signaling; Recurrence; Regulation; Reporter; RNA Interference; Signal Pathway; Signal Transduction; Signal Transduction Pathway; stem cell biology; Stem cells; Stereotyping; Study models; System; targeted agent; therapeutic target; Time; Tissues; To specify; Transforming Growth Factor beta; Transgenic Organisms; tumor; Vulva; Work; ,A C. elegans model for studying blocks to EGFR signal transduction in quiescent cells,126741,ZRG1,Special Emphasis Panel ,,,1,44044,,44044,
9395026,F30,AI,1,N,8/17/2017,8/17/2017,8/16/2018,855,F30AI120510,SCHOOLS OF MEDICINE,PA-16-305,1F30AI120510-01A1,NIAID:37544\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,STANFORD,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,18,9214214,US,8046501,STANFORD UNIVERSITY,CA,943041222,"Project narrative The prevalence of autoimmune and allergic diseases is steadily rising. In this proposal, we will characterize a novel class of potential therapeutic agents that may prove more potent than existing allergy therapies, and use this knowledge to design next generation anti-allergy agents.",11771409; ,"PENNINGTON, LUKE FRANKLIN;","GONDRE-LEWIS, TIMOTHY A",8/17/2017,8/16/2020,Acute; Affinity; Allergic; Allergic Disease; allergic response; Anaphylaxis; Ankyrin Repeat; anti-IgE; Antibodies; antibody libraries; Antigens; Autoimmune Diseases; base; Basophils; Binding; Binding Sites; Biological Assay; Cells; Cessation of life; Clinical; Complex; Conflict (Psychology); Country; Crystallization; design; Disease; Dissociation; Dose; Effector Cell; experimental study; Fc Receptor; glycosylation; Goals; Human; human disease; Hypersensitivity; IgE; IgE Receptors; in vivo; Incidence; inhibitor/antagonist; Knowledge; Ligands; mast cell; Mediating; Monoclonal Antibodies; mutant; Names; next generation; novel; novel therapeutics; omalizumab; Outcome; Passive Cutaneous Anaphylaxis; Pathogenesis; Pharmaceutical Preparations; Play; Prevalence; prevent; Process; protein complex; protein protein interaction; Proteins; Publishing; receptor; receptor binding; Role; Sampling; screening; Sequence Homology; Series; Signal Transduction; Structure; Symptoms; Testing; Therapeutic; Therapeutic Agents; Therapeutic Monoclonal Antibodies; therapeutic target; treatment response; Variant; Work; Yeasts; ,Disrupting IgE:FceR1a Interactions: Novel Therapies for Allergic Disease,120510,ZRG1,Special Emphasis Panel ,,A1,1,37544,,37544,
9469643,F31,DK,1,N,9/12/2017,9/30/2017,9/29/2018,847,F31DK116555,SCHOOLS OF MEDICINE,PA-16-309,1F31DK116555-01,NIDDK:35604\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,PHYSIOLOGY,12,73133571,US,1506502,UNIVERSITY OF MICHIGAN,MI,481091276,"Project Narrative Over one billion people are affected by iron-related disorders, which leads to massive morbidity and mortality worldwide. Our preliminary data challenges current dogma by showing that the maintenance of systemic iron metabolism by the hepatic-derived hormone, hepcidin, and the control of intestinal iron absorption by the transcription factor, HIF-2?, are directly integrated pathways. This project aims to understand the significance and molecular mechanism of the crosstalk between hepatic hepcidin and intestinal HIF-2?, which will provide novel insights into systemic iron homeostasis and will uncover potential therapeutic targets to alter systemic iron handling in diseases of iron overload and iron deficiency.",14471241; ,"SCHWARTZ, ANDREW JOSEPH;","DENSMORE, CHRISTINE L",9/30/2017,9/29/2020,absorption; Acute; Address; Affect; Alpha Cell; Apical; Autophagocytosis; base; bHLH-PAS factor HLF; Binding; Blood Circulation; Cell Line; Cells; Coupled; CRISPR/Cas technology; Data; Dietary Iron; Disease; Doxycycline; Erythropoiesis; Genetic; Goals; Heat-Shock Response; Hepatic; hepcidin; Homeostasis; Hormones; Human; Hypoxia Inducible Factor; Immunoprecipitation; insight; Intestines; Iron; iron deficiency; iron metabolism; Iron Metabolism Disorders; Iron Overload; Knock-out; Laboratories; Liver; liver metabolism; Lysosomes; Maintenance; Malnutrition; Mammals; Mass Spectrum Analysis; Mediating; metal transporting protein 1; Molecular; Molecular Chaperones; Morbidity - disease rate; mortality; mouse model; Mutation; novel; Organism; overexpression; Pathway interactions; peptide hormone; Process; Proteins; Regulation; Research; Research Proposals; Role; sensor; Signal Transduction; Site-Directed Mutagenesis; Stress; System; Tamoxifen; Technology; Testing; therapeutic target; Tissues; transcription factor; ubiquitin-protein ligase; Ubiquitination; ,Integration of Hepatic Hepcidin and Intestinal HIF-2 alpha in Systemic Iron Metabolism,116555,ZDK1,Special Emphasis Panel ,,,1,35604,,35604,
9470242,F31,GM,1,N,8/29/2017,9/1/2017,8/31/2018,859,F31GM123683,SCHOOLS OF ARTS AND SCIENCES,PA-16-309,1F31GM123683-01A1,NIGMS:34644\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,AUSTIN,UNITED STATES,BIOLOGY,25,170230239,US,578403,"UNIVERSITY OF TEXAS, AUSTIN",TX,787595316,"Project Narrative! Ciliopathies are a class of birth defects caused by defective cilia. This project will determine conserved ciliary protein complexes in a series of targeted proteomics experiments, systematically mapping ciliary protein organization as a guide for research into ciliopathies and cilia function.",14581969; ,"MCWHITE, CLAIRE D;","SMITH, WARD",9/1/2017,8/31/2019,Animals; base; Biochemical; Biological; Biological Models; Biological Process; biological systems; Biology; Candidate Disease Gene; Cilia; ciliopathy; cilium biogenesis; Clustered Regularly Interspaced Short Palindromic Repeats; Collection; comparative; Comparative Biology; Complex; Congenital Abnormality; Core Protein; Data; Data Set; Databases; Defect; Development; Disease; Embryo; Epithelium; Event; exome; experimental study; Eye; Fractionation; Future; Genes; Genetic screening method; Hand; Health; heart function; Hereditary Disease; Human; Human Genetics; in vivo; Investigation; Joubert syndrome; Kidney; Knock-out; Knockout Mice; Link; link protein; Machine Learning; Maps; Mass Spectrum Analysis; Measures; mental function; Methods; Modeling; Molecular Biology; Mus; Mutation; Noise; novel; Organism; Outcome; Pattern; Phenotype; Plant Proteins; Plants; Process; protein complex; protein protein interaction; Protein-Protein Interaction Map; Proteins; Proteomics; reproductive function; Research; Resources; Route; Sampling; Series; Signal Transduction; skeletal; Syndrome; System; Techniques; Testing; Whole Organism; Xenopus; Xenopus laevis; ,Proteomics of ciliopathy protein complexes,123683,ZRG1,Special Emphasis Panel ,,A1,1,34644,,34644,
9528774,K01,MH,7,N,10/19/2017,7/1/2017,3/31/2018,242,K01MH111374,SCHOOLS OF MEDICINE,PA-16-285,7K01MH111374-02,NIMH:130181\,OTHER RESEARCH-RELATED,2017,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW HAVEN,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,3,43207562,US,9420201,YALE UNIVERSITY,CT,65208327,"Project Narrative/ Public Health Relevance Statement: The proposed research is to develop a deeper understanding on the role of social capital and late HIV diagnosis in the United States (US), and to better understand mechanisms that link the two. The project also aims to develop an indicator of social capital tailored to HIV prevention that is distinctly different from traditional indicators (e.g., social cohesion or collective efficacy). My research is significant because intervening at the stage of HIV diagnosis could have significant downstream impact on lowering community-level viral load suppression and reducing HIV incidence in key populations. Social capital is a modifiable determinant that can be generated and leveraged for community-level HIV prevention interventions in the US setting.",10836510; ,"RANSOME, YUSUF ;","GREENWOOD, GREGORY",4/6/2017,3/31/2022,Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Affect; African American; AIDS prevention; AIDS/HIV problem; American; Anti-Retroviral Agents; Authorization documentation; base; Caribbean region; CD4 Lymphocyte Count; Cells; Cities; Clinical Research; cohesion; Committee Members; Communities; community based participatory research; Competence; Data; design; Diagnosis; Disclosure; disparity reduction; Environment; Epidemic; Epidemiology; ethnic difference; Ethnic Origin; Ethnography; Evaluation; Funding; General Population; Geography; Goals; Grant; Health Policy; High Prevalence; Hispanics; HIV; HIV diagnosis; HIV Infections; Household; Human immunodeficiency virus test; implementation science; improved; Incidence; Individual; innovation; Institutes; International; Interview; K-Series Research Career Programs; Learning; lens; Link; Mediating; medication compliance; member; Mentors; Methods; Mission; Morbidity - disease rate; mortality; Neighborhoods; New York; New York City; Pennsylvania; permissiveness; Persons; Philadelphia; Population; Prevalence; Prevention Research; Prevention strategy; Preventive Intervention; Probability; Public Health; public health relevance; Public Health Schools; Qualitative Research; Race; racial and ethnic; racial disparity; Research; research and development; Research Design; Research Methodology; Research Personnel; Research Support; Resources; Risk; Role; Sampling; Scientist; Series; social; social capital; social health determinants; social stigma; socioeconomics; Structure; surveillance data; Surveys; System; Testing; therapy development; Time; Training; transmission process; Trust; United States; United States National Institutes of Health; Universities; Viral; Viral Load result; Writing; ,Social Capital and Late HIV Diagnosis in the United States,111374,ZRG1,Special Emphasis Panel ,,,2,120538,9643,130181,
9587891,Y01,NS,,N,,,,,Y01NS170040,,,ANS17004000-0-0-1,NCCAM:10000\NIAMS:5000\,INTERAGENCY AGREEMENTS,2017,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,,,,,,,,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,,,; ,",  ;",,,,Advisory Committees; Office of Assistant Secretary of Health; operation; Pain management; ,Pain Management Best Practices Inter-Agency Task Force,,,,,,,,,15000,
9588677,Y01,DA,,N,,,,,Y01DA170030,,,ADA17003000-0-0-1,NIDA:75000\,INTERAGENCY AGREEMENTS,2017,NATIONAL INSTITUTE ON DRUG ABUSE,,,,,,,,,NATIONAL INSTITUTE ON DRUG ABUSE,,,,; ,",  ;",,,,,Bureau of Labor Statistics,,,,,,,,,75000,
9394727,I01,VA,5,N,10/16/2017,10/1/2017,9/30/2018,999,I01RX000444,,RFA-RX-14-001,5I01RX000444-08,,Non-SBIR/STTR RPGs,2017,Veterans Affairs,,CHARLESTON,UNITED STATES,,1,39807318,US,481111,RALPH H JOHNSON VA MEDICAL CENTER,SC,294015703,"PUBLIC HEALTH RELEVANCE:     Risk factors for age-related macular degeneration (AMD) involve single nucleotide polymorphisms in the alternative pathway (AP) of complement inhibitor factor H, as well as oxidative stress. We have developed and validated a targeted AP inhibitor as a possible therapeutic agent for the treatment of AMD. Here we wish to test an AAV5-vector-based delivery for CR2-fH in models of dry and wet AMD.",6573140; ,"ROHRER, BAERBEL ;",,10/1/2010,9/30/2018,adeno-associated viral vector; Adult; Age; Age related macular degeneration; Alternative Complement Pathway; American; Animal Model; Animals; Appearance; base; Blindness; Caring; Cell physiology; Cells; Cellular Structures; Choroidal Neovascularization; cigarette smoke; Clinical; clinical application; Clinical Trials; Complement; Complement 3d Receptors; Complement Activation; Complement Factor H; Complement Inactivators; Development; Disease; disorder prevention; DNA Sequence Alteration; Dose; Drug Kinetics; effective therapy; efficacy study; Ensure; Enzymes; experimental study; follow-up; Fundus; Future; gene complementation; Gene Expression; Genetic; Genetic Polymorphism; Genetic study; Goals; Growth Factor; immunoregulation; improved; In Vitro; in vivo; Incidence; Inflammation; inhibitor/antagonist; injured; Intravenous; intravitreal injection; Lasers; Learning; Ligand Binding Domain; Long-Term Effects; Macular degeneration; Measurable; Membrane; Methodology; Mitochondria; Modeling; Monkeys; monolayer; mouse model; Mus; Mutation; Normal Cell; Normalcy; Ocular Pathology; Oxidative Stress; Pathogenesis; Pathologic; Pathology; Pathway interactions; Patients; Phagocytosis; Phase I Clinical Trials; Photoreceptors; Population; Prevalence; promoter; Proteins; public health relevance; Quality of life; rat Piga protein; Retina; Retinal; Risk; Risk Factors; Safety; safety testing; Single Nucleotide Polymorphism; Site; Smoke; Smoking; Specialist; Structure; System; Testing; Therapeutic; Therapeutic Agents; Time; Toxicology; vector; Veterans; Viral Vector; Vitronectin; ,Complement Factor H-based Therapeutic Strategies in Macular Degeneration,444,RRD3,Sensory Systems/Communication Disorders ,,,8,,,,
9396590,F31,AA,1,N,9/6/2017,9/25/2017,9/24/2018,273,F31AA025826,,PA-16-309,1F31AA025826-01A1,NIAAA:28044\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BETHESDA,UNITED STATES,,8,144676566,US,1809301,HENRY M. JACKSON FDN FOR THE ADV MIL/MED,MD,208171888,Narrative Excessive alcohol use remains a significant public health problem in the US. A better understanding of the psychological processes underlying excessive drinking is needed. The proposed study will examine a laboratory model of impaired control by comparing self-administration of alcohol in the laboratory and drinking in the participant?s usual environment; results from the study may facilitate the development of better interventions.,14637583; ,"SELLS, JOANNA ;","SHIRLEY, MARIELA",9/25/2017,9/24/2019,Alcohol consumption; alcohol exposure; Alcoholic beverage heavy drinker; Alcohols; Algorithms; base; Behavior; Clinical; cognitive testing; Consumption; Data; Development; Dose; drinking; drinking behavior; Ecological momentary assessment; effective intervention; Environment; Failure; Goals; Heavy Drinking; high risk drinking; Human; Impairment; Individual; Intervention; Intravenous; Investigation; Laboratories; Measures; Modeling; Motivation; novel; Outcome; Participant; Patient Self-Report; Pharmacology; physiologic model; Population; Process; psychologic; Public Health; Questionnaires; Reporting; Research; Risk; Self Administration; Self-Administered; tool; ,Impaired Control over Alcohol Consumption: Laboratory and Field Investigations,25826,ZAA1,Special Emphasis Panel ,,A1,1,28044,,28044,
9468212,F32,GM,1,N,8/28/2017,9/9/2017,9/8/2018,859,F32GM126706,SCHOOLS OF ARTS AND SCIENCES,PA-16-307,1F32GM126706-01,NIGMS:56694\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,AUSTIN,UNITED STATES,BIOLOGY,25,170230239,US,578403,"UNIVERSITY OF TEXAS, AUSTIN",TX,787595316,"Project Narrative  Bacteria interact with animal hosts on a biochemical level, but the nuances that distinguish pathogenic from symbiotic bacterial interactions are not well characterized. Understanding how animal hosts control their symbionts will provide insight into the development of novel therapies that: 1) selectively target pathogenic bacteria, avoiding beneficial symbionts, and 2) target insects that spread human disease and depend on symbiosis. There is evidence that pea aphids regulate their symbiotic bacteria by taking control of bacterial cell wall recycling, a mechanism that is very likely widespread amongst animal-bacteria interactions, and this idea will be tested herein.",12597957; ,"SMITH, THOMAS E;","WILLIS, KRISTINE AMALEE",9/9/2017,9/8/2020,Affect; African Trypanosomiasis; Animal Model; Animals; Antibiotics; Aphids; Back; Bacteria; base; Binding; Biochemical; Biochemical Genetics; Biological Assay; Body cavities; body cavity; Bordetella pertussis Bacterium; Buchnera; Buchnera aphidicola; Cardiovascular Diseases; Cell division; cell envelope; Cell Wall; Cells; Chagas Disease; commensal microbes; Communication; Development; Disease; Disease Vectors; Domestic Animals; Engineering; Enzymes; Equilibrium; Eukaryota; experimental study; fitness; flexibility; Gene Expression; Gene Expression Profile; gene function; gene product; Genes; Genetic; genetic approach; Genome; genome-wide; Genotype; Goals; gut microbiome; Homeostasis; Human; human disease; Immunofluorescence Immunologic; In Vitro; in vivo; Infection; Inflammatory Bowel Diseases; insect disease; Insecta; insight; Invaded; Investigation; Knowledge; Lead; Light; Link; Membrane; Microbe; microbial; microorganism interaction; Modeling; Neisseria gonorrhoeae; new therapeutic target; novel; novel strategies; novel therapeutics; Nutritional; Obesity; pathogen; pathogenic bacteria; Pathogenicity; Pathway interactions; Peptidoglycan; Phenotype; Pisum; Pisum sativum; Play; Population; Population Sizes; Prevention; Process; Prokaryotic Cells; Proteins; Proteomics; Recombinants; Recycling; Regulation; response; Role; Serratia; Signal Pathway; Small Interfering RNA; Structure; Substrate Specificity; Symbiosis; System; Testing; tool; transcriptomics; Variant; Vesicle; Vibrio fischeri; Work; ,Investigations of the role of host controlled peptidoglycan recycling in the regulation of the pea aphid-Buchnera symbiosis,126706,ZRG1,Special Emphasis Panel ,,,1,56694,,56694,
9468745,F30,HD,1,N,9/20/2017,9/22/2017,9/21/2018,865,F30HD091975,SCHOOLS OF MEDICINE,PA-16-305,1F30HD091975-01A1,NICHD:28711\,"TRAINING, INDIVIDUAL",2017,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,WORCESTER,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,2,603847393,US,850903,UNIV OF MASSACHUSETTS MED SCH WORCESTER,MA,16550002,"RR-8: PROJECT NARRATIVE One out of every three children under the age of five in India are undernourished (48 million); to address this crisis, Indian government established a national program from 2005-2012. This study will apply advanced geospatial and multilevel methods to investigate 1) the changes in child undernutrition in India from 2005 to 2012, 2) individual, household, and community level predictors of child undernutrition, and 3) consequences of undernutrition on development during pre-adolescent (8-11) years. Results from this study can guide effective policymaking and implementation of intervention programs.",14340675; ,"SONI, APURV ;","BURES, REGINA M",9/22/2017,9/21/2021,5 year old; Academic achievement; Accounting; Address; Adolescent; Advocacy; African; Age; aged; Anthropology; Area; base; career; Caring; Cessation of life; Characteristics; Child; Child Care; Child Development; Child health care; Child Malnutrition; Child Mortality; Clinical; clinical practice; Communities; community based participatory research; Community Healthcare; Complex; Country; Data; Data Set; Data Sources; Decision Making; Development; Dietary intake; Disease; Economics; Environmental Risk Factor; evidence base; Expenditure; experience; Female; Food; Foundations; Funding; Gender; Goals; Government; Growth; Health; health disparity; Health Status; Healthcare; Heterogeneity; High Prevalence; Household; Human Development; Hygiene; Impairment; improved; India; Individual; Intervention; intervention program; Investigation; Knowledge; Life; Life Cycle Stages; Life Expectancy; low and middle-income countries; Malnutrition; Maternal Mortality; Mentorship; Methodology; Methods; Mission; model building; Morbidity - disease rate; Mothers; multilevel analysis; National Institute of Child Health and Human Development; Newborn Infant; Nutritional; Observational Study; Outcome; Physicians; Policies; population health; Positioning Attribute; Pregnant Women; Prevalence; Productivity; programs; Publishing; Quality of life; Research; Research Infrastructure; Research Proposals; Resources; Role; Rural Health; Sanitation; Scientist; Series; Services; spatiotemporal; Surveys; Techniques; Training; trend; United States National Institutes of Health; Water; Women's Role; ,"Trends, Predictors, and Consequences of Child Undernutrition",91975,ZRG1,Special Emphasis Panel ,,A1,1,28711,,28711,
9469138,F31,CA,1,N,9/6/2017,9/30/2017,9/29/2018,398,F31CA224809,SCHOOLS OF MEDICINE,PA-16-308,1F31CA224809-01,NCI:48403\,"TRAINING, INDIVIDUAL",2017,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,PHARMACOLOGY,11,77758407,US,218601,CASE WESTERN RESERVE UNIVERSITY,OH,441061712,PROJECT NARRATIVE Breast cancer is a collection of diseases that are defined by the activity of their genes. This proposal focuses on identifying the regulatory switches that control genes driving the aggressive features of tumors known as triple negative breast cancers. This approach should reveal key genes and their regulatory processes that could serve as new therapeutic targets in breast cancer.,10958402; ,"WEBB, BRYAN MONROE;","MCNEIL, NICOLE E",9/30/2017,9/29/2020,Affect; Alpha Cell; Automobile Driving; base; Breast Cancer cell line; Cancer cell line; Cancer Patient; cancer subtypes; Candidate Disease Gene; Cell Line; cell motility; cell type; Cells; ChIP-seq; Clinic; Clinical; clinically relevant; Collection; CRISPR/Cas technology; Data; Disease; Disease Progression; DNA; Enhancers; Epidermal Growth Factor Receptor; Epigenetic Process; epigenome; Essential Genes; Estrogen Receptors; Event; FDA approved; Foundations; Future; Gene Expression; Gene Proteins; gene repression; Gene Silencing; Genes; Genome; Genomics; Goals; Growth; Histones; Human; human disease; improved; In Vitro; in vivo; insight; Kinetics; Knowledge; Link; Maintenance; malignant breast neoplasm; Malignant Neoplasms; malignant phenotype; Maps; Mesenchymal; Messenger RNA; migration; Modeling; Modification; Molecular; Mus; Neoplasm Metastasis; new therapeutic target; Non-Malignant; Oncogenes; Outcome; outcome forecast; Pathway interactions; Patients; Pattern; Pharmaceutical Preparations; Phenotype; Plasticizers; Process; Progesterone Receptors; Proteins; Reporting; senescence; Small Interfering RNA; stem; targeted treatment; Testing; Therapeutic Intervention; therapeutic target; therapy development; transcription factor; transcriptome; triple-negative invasive breast carcinoma; tumor; tumor growth; tumor progression; tumorigenesis; Woman; Xenograft procedure; ,Defining the Super-Enhancer Landscape in Triple Negative Breast Cancer Subtypes,224809,ZRG1,Special Emphasis Panel ,,,1,48403,,48403,
9469809,F31,CA,1,N,9/14/2017,9/15/2017,9/14/2018,398,F31CA224800,SCHOOLS OF MEDICINE,PA-16-308,1F31CA224800-01,NCI:45411\,"TRAINING, INDIVIDUAL",2017,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,ADMINISTRATION,12,60217502,US,1514803,WEILL MEDICAL COLL OF CORNELL UNIV,NY,100654805,"PROJECT NARRATIVE Nearly 1.4 million individuals are diagnosed with CRC each year, and we have almost no targeted, non-surgical options for these patients. Our work will determine the efficacy of suppressing WNT signaling in CRCs that carry a large genome deletion. This work will contribute significantly to our goal of developing more targeted treatment options to improve clinical outcomes in WNT-driven cancers.",11968425; ,"SCHATOFF, EMMA M;","MCNEIL, NICOLE E",9/15/2017,9/14/2021,advanced disease; Attention; base; Biological Models; cancer cell; Cancer Cell Growth; cancer type; Cell Compartmentation; Cell Proliferation; Cessation of life; chromosome 8p loss; Chromosome Deletion; Chromosomes; Clinical; Clinical Data; Clinical Management; Clustered Regularly Interspaced Short Palindromic Repeats; Colon; colon cancer patients; Colorectal Cancer; Data; Dependence; Development; Diagnosis; Diploidy; Disease; dosage; Dose; Dose-Limiting; Drug Delivery Systems; early onset; Engineering; Enzymes; Family member; Gene Silencing; Genes; genetic approach; Genome; genome editing; Goals; Haploidy; Human; Hyperactive behavior; improved; in vivo; Individual; inhibitor/antagonist; intestinal epithelium; Intestines; knock-down; Lead; Lesion; malignant breast neoplasm; Malignant neoplasm of lung; Malignant Neoplasms; Mediating; Mentors; mortality; mouse model; Mus; neoplastic cell; Normal Cell; Oncogenic; Organoids; Outcome; Pathogenesis; Pathway interactions; Patients; Pharmaceutical Preparations; Pharmacology; pre-clinical; Pre-Clinical Model; Primary carcinoma of the liver cells; Proteins; Public Health; Recurrence; response; screening; Signal Transduction; small hairpin RNA; small molecule inhibitor; Specificity; Stem cells; System; Tankyrase; targeted treatment; Technology; Testing; Therapeutic; Therapeutic Index; therapeutic target; TNKS gene; tool; Toxic effect; Transgenic Organisms; Transplantation; tumor; Tumor Cell Line; tumor progression; Ursidae Family; WNT Signaling Pathway; Work; ,Targeting the WNT Pathway in Colorectal Cancer,224800,ZRG1,Special Emphasis Panel ,,,1,45411,,45411,
9575205,I21,VA,7,N,10/16/2017,10/1/2017,6/30/2018,999,I21RX002200,,RFA-RX-16-001,7I21RX002200-03,,RESEARCH CENTERS,2017,Veterans Affairs,,SALT LAKE CITY,UNITED STATES,,2,9094756,US,481089,VA SALT LAKE CITY HEALTHCARE SYSTEM,UT,841480001,"PUBLIC HEALTH RELEVANCE    An estimated 60-80% of persons with spinal cord injury (SCI) experience neuropathic pain with 1/3 describing their pain as severe. Although there are currently preclinical models of SCI-induced pain, there have been few successes in translation of new treatments from rodent models to clinical practice, suggesting that development of highly clinically-relevant preclinical model will facilitate discovery and translation of new treatments. Since pigs are very similar to humans in many aspects of physiology and pathophysiology, we hypothesize that a porcine model of SCI-induced neuropathic pain is a much needed tool to improve the discovery of new treatments. Thus, in this research we will characterize and validate a new porcine model of SCI-induced neuropathic pain.",2056133; ,"FLOYD, CANDACE L.;",,7/1/2016,6/30/2018,Acoustics; Adult; allodynia; Anatomy; Animal Model; Caring; Chest; Chronic; chronic neuropathic pain; chronic pain; Clinical; clinical practice; clinically relevant; combat; Conflict (Psychology); Data; dermatome; Development; Disease; Drug Kinetics; effective therapy; Electrophysiology (science); Evaluation; experience; experimental study; Face; Facial Expression; Family suidae; Foundations; Functional disorder; Future; Genetic; Goals; Human; Hyperalgesia; Hyperreflexia; image guided; improved; Incidence; Injury; innovation; Knowledge; Lesion; male; man; Maps; Measures; Medical; Methodology; Methods; Microscopy; Military Personnel; Modeling; Morphology; Motor; Nerve; nerve supply; Neuroanatomy; Neuronavigation; Neuropathy; novel; Outcome Measure; Pain; Pain Measurement; painful neuropathy; Pathogenesis; Pathology; Patients; Peripheral; Persons; Physiological; Physiology; Pre-Clinical Model; pre-clinical research; Predictive Value; Procedures; public health relevance; reconstruction; Recovery of Function; Reflex action; repaired; Reporting; Research; research clinical testing; response; Rodent; Rodent Model; Sensory; Spinal; Spinal Cord; Spinal Cord Contusions; Spinal cord injury; spinal tract; Spine pain; Stimulus; success; Symptoms; Tactile; Testing; Therapeutic; Therapeutic Intervention; tool; Translational Research; Translations; Treatment Efficacy; United States; Validation; Veterans; vocalization; Withdrawal; Work; ,Development of a clinically-relevant SCI-induced pain model,2200,RRDS,Rehabilitation Research and Development SPiRE Program ,,,3,,,,
9589590,Y01,DA,,N,,,,,Y01DA150020,,,ADA15002000-0-0-1,NIDA:3000000\,INTERAGENCY AGREEMENTS,2017,NATIONAL INSTITUTE ON DRUG ABUSE,,,,,,,,,NATIONAL INSTITUTE ON DRUG ABUSE,,,,; ,",  ;",,,,,VA Cooperative Studies Program,,,,,,,,,3000000,
9398010,F31,NR,1,N,8/21/2017,9/1/2017,8/31/2018,361,F31NR017344,SCHOOLS OF NURSING,PA-16-308,1F31NR017344-01,NINR:44044\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF NURSING RESEARCH,,DURHAM,UNITED STATES,NONE,1,44387793,US,2221101,DUKE UNIVERSITY,NC,277054673,"PUBLIC HEALTH RELEVANCE Sickle cell disease (SCD) is debilitating condition that requires complex disease self-management to maintain optimal health and quality of life. Patients with SCD often experience high levels of stigma which can be a barrier to adequate self-management and impede quality of life. This research will advance the understanding of the relationships between stigma, self-management, and quality of life in SCD in the United States and Jamaica.",14758045; ,"BULGIN, DOMINIQUE C;","BANKS, DAVID",9/1/2017,6/30/2020,Acute; Adult; Affect; African; Age; Attitude; Blood Transfusion; care seeking; career; Caring; Characteristics; chronic pain; Clinical; Complex; Country; Cross-Sectional Studies; demographics; design; Development; Disease; Emotional; experience; Face; Female; Fright; Genetic; Genotype; Goals; Health; Health Personnel; Hematological Disease; High Prevalence; Hydration status; hydroxyurea; improved; Individual; Intervention; Interview; Jamaica; Lead; Leg Ulcer; Link; Longevity; Lung diseases; male; Measurement; Measures; Mental Depression; Methods; Morbidity - disease rate; mortality; Opioid; opioid use; Organ; Organ failure; Pain; Pain management; Participant; Patient Self-Report; Patients; Perception; Persons; Pharmaceutical Preparations; Play; Population; prevent; programs; Provider; public health relevance; Quality of life; Questionnaires; Race; Research; Research Personnel; Role; Science; Self Management; Severity of illness; sex; Sickle Cell; Sickle Cell Anemia; Sleep; Social Functioning; social stigma; Societies; Socioeconomic Status; Source; Stigmatization; Surveys; tool; United States; Work; ,Understanding the Intersection of Stigma and Self-Management in Sickle Cell Disease,17344,NRRC,National Institute of Nursing Research Initial Review Group ,,,1,44044,,44044,
9468620,F31,NS,1,N,9/19/2017,9/1/2017,8/31/2018,853,F31NS105379,GRADUATE SCHOOLS,PA-16-309,1F31NS105379-01,NINDS:44044\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,3,43207562,US,9420201,YALE UNIVERSITY,CT,65208327,"PROJECT NARRATIVE This proposal addresses the molecular mechanism underpinning spinal muscular atrophy (SMA), a devastating neurodegenerative disease that leads to the loss of motor neurons, progressive muscle wasting, and early death. SMA is linked to a genetic mutation in the gene encoding survival of motor neuron protein(SMN), which concentrates in a cellular compartment ? the Cajal body ? where gene expression is regulated. We seek to address the role of Cajal bodies in SMA, with the aim of understanding how they assemble in neurons.",14677146; ,"COURCHAINE, EDWARD MICHAEL;","NUCKOLLS, GLEN H",9/1/2017,8/31/2020,Address; Affect; Affinity; Animal Model; Binding; Binding Proteins; Biogenesis; Biological Assay; Biological Models; biophysical techniques; Body Composition; Cell Nucleus; Cessation of life; Childhood; Complement; Complex; crosslink; Cytoplasm; Defect; Development; DNA Sequence Alteration; Embryo; Embryonic Development; Failure; Fish Proteins; Gene Expression; Genes; Genetic; Goals; Image; Immunoprecipitation; In Vitro; in vivo; insight; Kinetics; knock-down; Knock-out; Knowledge; Larva; Left; Light; Link; Literature; Mass Spectrum Analysis; Measures; member; Membrane Lipids; Messenger RNA; Methods; Microscopy; Modeling; Molecular; Motor Neurons; mRNA Precursor; Muscular Atrophy; Neurodegenerative Disorders; Neurons; Nuclear; Organelles; Pathologic; Pathology; Protein Deficiency; Proteins; Recombinant Proteins; Recombinants; Recruitment Activity; RNA; RNA Binding; RNA Splicing; Role; single molecule; Small Nuclear Ribonucleoproteins; SMN protein (spinal muscular atrophy); Spinal Muscular Atrophy; stoichiometry; Structure; Surveys; Techniques; Testing; Time; tissue culture; Tissues; Total Internal Reflection Fluorescent; Transcript; transcriptome sequencing; Work; Zebrafish; Zebrafish Proteins; ,Cajal body assembly mechanisms in vitro and in the context of neurodegenerative disease,105379,ZRG1,Special Emphasis Panel ,,,1,44044,,44044,
9470066,F31,CA,1,N,9/20/2017,9/20/2017,9/19/2018,398,F31CA217148,SCHOOLS OF MEDICINE,PA-16-308,1F31CA217148-01A1,NCI:40234\,"TRAINING, INDIVIDUAL",2017,NATIONAL CANCER INSTITUTE,,DETROIT,UNITED STATES,PHARMACOLOGY,13,1962224,US,9110501,WAYNE STATE UNIVERSITY,MI,482024050,"Research Narrative Colorectal cancer (CRC) is a one of the deadliest cancers with limited chemotherapeutic and targeted drug therapies available. We identified the protease TMPRSS13 to be upregulated in CRC, and we hypothesize that TMPRSS13 has properties which lead to protection from cell death and modulation of oncogenic proteins. Using tissue culture and mouse models of disease, we will identify the mechanisms underlying the role of TMPRSS13 in pro-tumorigenic cellular processes and detail its impact on CRC development and progression.",11953167; ,"VARELA, FAUSTO ALEXANDER;","MCNEIL, NICOLE E",9/20/2017,9/19/2019,Apoptosis; Attention; base; Binding; Biochemical; Biological Assay; Biology; cancer cell; cancer initiation; cancer therapy; cancer type; Cell Culture Techniques; Cell Death; cell motility; Cell physiology; Cell Proliferation; Cell Survival; Chemicals; chemotherapeutic agent; chemotherapy; colon cancer cell line; colon carcinogenesis; Colon Carcinoma; Colonic Adenoma; Colonic Neoplasms; Colorectal Cancer; combat; Complement; Computer Simulation; CRISPR/Cas technology; Cytoprotection; Data; design; Development; Disease; Disease model; Drug Targeting; Drug usage; experimental study; extracellular; Extracellular Matrix Degradation; Fluorouracil; Genes; Growth; Histologic; Human; Impairment; improved; In Vitro; in vivo; Inflammation; Inflammatory Bowel Diseases; inhibitor/antagonist; insight; Intervention; knock-down; Knockout Mice; Lead; Malignant Neoplasms; Mediating; Mediator of activation protein; men; Modeling; Molecular; mouse model; Mus; Neoplastic Cell Transformation; novel; Oncogenic; Peptide Hydrolases; Pharmacotherapy; Physiologic pulse; Physiological; Physiology; Play; Post-Translational Protein Processing; Process; promoter; Property; Protein Family; Proteins; Proteolysis; Publishing; Regulation; Reporting; Research; Resistance; Risk; RNA Interference; Role; Serine Protease; Signal Pathway; Signal Transduction; Small Interfering RNA; targeted treatment; Techniques; Testing; Tight Junctions; tissue culture; Tissue Microarray; Tissues; Transcript; Treatment Efficacy; treatment strategy; tumor; tumor growth; tumor progression; Tumor Tissue; tumorigenesis; tumorigenic; Tumorigenicity; United States; Woman; Work; ,TMPRSS13 as a Modulator of Colorectal Cancer,217148,ZRG1,Special Emphasis Panel ,,A1,1,40234,,40234,
9567848,I01,VA,5,N,10/16/2017,7/1/2017,6/30/2018,999,I01RX001299,,RFA-RX-14-001,5I01RX001299-04,,Non-SBIR/STTR RPGs,2017,Veterans Affairs,,BOSTON,UNITED STATES,,7,34432265,US,481041,VA BOSTON HEALTH CARE SYSTEM,MA,21304817,"PUBLIC HEALTH RELEVANCE:     The retinal degenerative diseases age-related macular degeneration (AMD) and retinitis pigmentosa (RP) account for ~40% of the cases of legal blindness within the VA system. Restoring vision loss in these patients is a goal of many researchers, who are using different therapeutic strategies, including retinal prosthetic implants, optogenetics, stem cell treatments, and gene therapy. A novel approach is the use of a pharmacological agent that acts specifically on synaptic receptors to facilitate transmission of residual, visual signals in the retinas of thes patients. The long-term objective is to extend the period of useful vision in patients with retinal degenerative disorders by increasing light responsiveness of retinal ganglion cells (RGCs), the output neurons of the retina, through the use of a pharmacological agent that acts on the inner retinal circuitry.",1880968; ,"JENSEN, RALPH J.;",,7/1/2014,6/30/2018,Affect; Age related macular degeneration; Animal Model; Blindness; Cells; Degenerative Disorder; follow-up; gamma-Aminobutyric Acid; gene therapy; Glutamates; Goals; GRM1 gene; Implant; improved; In Vitro; Legal Blindness; legal cases; Light; Modeling; multi-electrode arrays; Mus; Neurons; Neurotransmitter Receptor; novel strategies; optogenetics; Output; Patients; Pharmacology; Pharmacotherapy; Photophobia; photoreceptor degeneration; Photoreceptors; Preparation; presynaptic; Presynaptic Terminals; Property; public health relevance; Rattus; receptive field; receptor; Reporting; Reproducibility; Research Personnel; Residual state; response; Retina; Retinal; Retinal Degeneration; Retinal Ganglion Cells; retinal prosthesis; Retinitis Pigmentosa; Signal Transduction; Stem cells; Stimulus; Synaptic Receptors; System; Therapeutic; transmission process; Vision; Visual; Visual Perception; visual stimulus; ,Pharmacotherapy for Retinal Degenerative Disorders,1299,RRD3,Sensory Systems/Communication Disorders ,,,4,,,,
9587883,Y01,NS,,N,,,,,Y01NS130010,,,ANS13001000-0-0-1,NINDS:135000\,INTERAGENCY AGREEMENTS,2017,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,,,,,,,,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,,,; ,",  ;",,,,Healthy People 2020; Heart Diseases; stroke; ,Healthy People 2020 Heart Disease and Stroke,,,,,,,,,135000,
9589588,Y01,DA,,N,,,,,Y01DA170010,,,ADA17001001-1-0-1,NIDA:332794\,INTERAGENCY AGREEMENTS,2017,NATIONAL INSTITUTE ON DRUG ABUSE,,,,,,,,,NATIONAL INSTITUTE ON DRUG ABUSE,,,,; ,",  ;",,,,,Naval Research Laboratory,,,,,,,,,332794,
9312131,IK1,VA,5,N,10/16/2017,10/1/2017,9/30/2018,999,IK1RX002111,,RFA-RX-16-008,5IK1RX002111-02,,OTHERS,2017,Veterans Affairs,,DECATUR,UNITED STATES,,4,824835805,US,481023,VETERANS HEALTH ADMINISTRATION,GA,300334004,"Nearly 20% of veterans in the VA system have diabetes, and diabetes prevalence is expected to rise to 35% by 2025. One of the most common complications of diabetes, diabetic retinopathy, is the leading cause of blindness in working age adults. In addition, changes in the neurons of the diabetic retina occur prior to other retinal damage and are likely intimately related to other diabetic complications, for example, cognitive decline and structural changes in the brain. The continued rise in the number of diabetic patients and the complexity of their care underscores the urgent need to identify an earlier window for treatment. We seek to identify this window and develop clinically translatable treatments to target complications prior to obvious signs and symptoms. If successful in rats, exercise interventions and treatments to restore neuron dysfunction could be translated to clinical application in the VA patient population.",10756261; ,"ALLEN, RACHAEL STEWART;",,10/1/2016,9/30/2018,"3,4-Dihydroxyphenylacetic Acid; Adult; Affect; Age; Age-Years; Animal Model; Appearance; Award; base; Binding; Biological Markers; biomarker identification; Blindness; Blood capillaries; Blood Circulation; Blood Vessels; Brain; capillary; career development; Caring; Cerebrum; Clinical; clinical application; Clinical Trials; clinically relevant; clinically translatable; Cognition; Cognitive deficits; Communities; Complications of Diabetes Mellitus; Defect; Development; Diabetes Mellitus; diabetic; diabetic patient; diabetic rat; Diabetic Retinopathy; Disease; Disease model; Dopamine; Early identification; Early Intervention; Early treatment; Electroretinography; Environment; Exercise; Exercise intervention; exercise regimen; Exhibits; experimental study; Foundations; Functional disorder; Future; Goals; Healthcare Systems; High Pressure Liquid Chromatography; Histology; Human; Hyperglycemia; Impaired cognition; Injury; Insulin-Dependent Diabetes Mellitus; interest; Intervention; Lead; Levodopa; macular edema; member; Metabolism; Modeling; Motivation; motor deficit; motor disorder; neovascularization; Neurocognitive; Neuronal Dysfunction; Neurons; Non-Insulin-Dependent Diabetes Mellitus; Optical Coherence Tomography; Outcome Study; Parkinson Disease; Pathologic; Pathology; patient population; Patients; Pattern; Pericytes; Population; pre-clinical; Prevalence; prevent; Prevention; Prevention Protocols; Rattus; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; response; restoration; Retina; Retinal; retinal damage; Retinal Diseases; retinal ischemia; Rodent; Rodent Model; Scientist; Signs and Symptoms; Structure; Symptoms; System; Testing; Time; Training; Translating; Treatment Efficacy; Veterans; Visual; ",Neuroprotective strategies for retinopathy and cognition in diabetes,2111,RRD8,Career Development Program - Panel I ,,,2,,,,
9326722,F32,CA,1,N,9/4/2017,9/5/2017,9/4/2018,398,F32CA210540,,PA-16-307,1F32CA210540-01A1,NCI:58326\,"TRAINING, INDIVIDUAL",2017,NATIONAL CANCER INSTITUTE,,DAVIS,UNITED STATES,,3,47120084,US,577503,UNIVERSITY OF CALIFORNIA AT DAVIS,CA,956186153,"Project Narrative Breast cancer often metastasizes to bone and bone marrow, causing significant pain and decrease in patient quality of life. This project will focus on recreating a small portion of the bone and bone marrow within a 3D physical model system to study breast cancer cell interaction with the other cell types found in these specialized compartments.",12602334; ,"GLASER, DREW ELIZABETH;","JAKOWLEW, SONIA B",9/5/2017,9/4/2020,Address; Adherent Culture; Adhesions; Affect; analog; Area; Behavior; Biochemical; Biological; Biological Assay; Biological Models; Biomedical Engineering; Blood Vessels; bone; Bone Marrow; Breast Cancer Cell; Cancer Biology; cancer cell; cancer stem cell; cancer therapy; career; cell behavior; Cell Communication; cell motility; cell type; Cells; design; Development; Device Designs; Devices; Diagnosis; Endothelial Cells; Ensure; Environment; Event; Fellowship; Generations; Genetic; Goals; Hematopoietic stem cells; human tissue; Impairment; In Vitro; in vitro Assay; in vitro Model; in vivo; Indolent; insight; Integrin alphaVbeta3; Integrin beta3; Investigation; Ligands; Light; malignant breast neoplasm; MDA MB 231; Mentors; Mesenchymal Stem Cells; Metastatic Neoplasm to the Bone; Microfluidic Microchips; Microfluidics; migration; Modeling; Modification; mortality; mouse model; Mus; Neoplasm Metastasis; neoplastic cell; novel; Osteoblasts; outcome forecast; Pain; Patients; permissiveness; physical model; Physiological; Primary Neoplasm; Proliferating; Quality of life; Research; Research Personnel; Resistance; response; Role; Side; Signal Transduction; skills; small molecule; soft tissue; Source; Stromal Cells; System; Technology; temporal measurement; Therapeutic; Time; Tissues; tool; trafficking; Training; triple-negative invasive breast carcinoma; tumor; Tumor Cell Migration; tumor microenvironment; tumor progression; United States; Universities; Up-Regulation; Validation; Washington; Woman; Work; ,A Microfluidics Approach to Investigate Tumor Cell Trafficking in Bone Marrow,210540,ZRG1,Special Emphasis Panel ,,A1,1,58326,,58326,
9354200,I01,VA,5,N,10/18/2017,10/1/2017,9/30/2018,999,I01RX001325,,RFA-RX-14-001,5I01RX001325-04,,Non-SBIR/STTR RPGs,2018,Veterans Affairs,,HINES,UNITED STATES,,7,67445429,US,481028,EDWARD HINES JR VA HOSPITAL,IL,601413030,"PUBLIC HEALTH RELEVANCE:     Relevance to the VA. COPD is the 3rd leading cause of death in the United States and the 6th most common chronic condition cited among veterans enrolled in the Veterans Health Administration (VHA). In 2010, nearly 300,000 VA patients were diagnosed with COPD. Moreover, COPD is the 5th leading cause of VHA hospitalization. Compared with the general population, COPD patients are more likely to rate their health as poor, to report more limitations in daily activities and more disability days, to visit a physician, and to be hospitalized. In the short- term, pulmonary rehabilitation can improve several chronic hindrances of COPD. Unfortunately, is unclear how to maintain rehabilitation benefits over the long-term. We reason that developing a successful strategy to ensure long-term maintenance of physical activity and breathing-retraining in COPD, as planned in this proposal, has the potential to modify the spiraling pattern of increasing respiratory impairment leading to mounting physical limitations and, possibly, reduce health-care cost and mortality in COPD.",6110418; 9398805 (contact); ,"COLLINS, EILEEN G; LAGHI, FRANCO  (contact);",,10/1/2014,9/30/2018,Adherence; Affect; Airway Obstruction; Anxiety; base; Breathing; Cause of Death; Chronic; Chronic Obstructive Airway Disease; Clinical; clinical phenotype; design; Development; Diagnosis; Dimensions; disability; Dyspnea; Effectiveness; Enrollment; Ensure; Exercise; exercise program; Exercise Tolerance; exercise training; Exhalation; Fatigue; follow-up; functional decline; functional status; General Population; Health; health administration; Health Care Costs; Home environment; Hospitalization; Impairment; improved; Intention; interest; Intervention; intervention program; Laboratories; Linear Regressions; Maintenance; Measurement; Measures; Mental Depression; Methods; Modeling; mortality; motivational enhancement therapy; Muscle function; muscle strength; novel; Outcome Measure; Participant; Patients; Pattern; Phenotype; Phonation; Physical activity; Physicians; Physiological; primary outcome; Program Sustainability; programs; psychologic; Psychological Factors; public health relevance; Pulmonary function tests; pulmonary rehabilitation; quadriceps muscle; Quality of life; Randomized; Randomized Controlled Clinical Trials; Rehabilitation therapy; Reporting; Research; respiratory; Respiratory Muscles; Risk; Sampling; secondary analysis; Self Efficacy; Severities; study characteristics; Study Subject; Supervision; Symptoms; Tail; Techniques; Telephone; Testing; Time; Training; treadmill; Treadmill Tests; Ultrasonography; United States; Veterans; Visit; Walking; Work; ,Sustainability of Rehabilitation Gains in COPD,1325,RRD2,Musculoskeletal/Orthopedic Rehabilitation  ,,,4,,,,
9395386,F32,GM,1,N,7/11/2017,9/30/2017,9/29/2018,859,F32GM125238,SCHOOLS OF MEDICINE,PA-16-307,1F32GM125238-01,NIGMS:57396\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,GENETICS,7,47006379,US,3212902,HARVARD MEDICAL SCHOOL,MA,21156027,"PROJECT NARRATIVE One of biology's greatest unsolved mysteries is how a single-cell develops and differentiates into a fully formed organism, and at the center of the process of cellular differentiation is well-coordinated and regulated gene expression. A critical first step to understanding how the genome regulates itself during differentiation is to clarify the transcriptional events that occur during differentiation, as missteps in the regulatory mechanisms controlling transcription result in many human diseases, particularly cancer. This research proposes to establish a timeline of the transcriptional events that occur as human stem cells become red blood cells, contributing to our understanding of how inaccuracies in transcription during differentiation result in cancers and other associated diseases and putting us one step closer to understanding how the genome regulates itself during differentiation.",11008859; ,"SMART, DANYA J;","WILLIS, KRISTINE AMALEE",9/30/2017,9/29/2020,Acute Lymphocytic Leukemia; Adult; Biology; Bromodomain; cancer cell; Cell physiology; cell type; Cells; Chromatin; Chronology; Complex; Coupled; Coupling; Development; developmental disease/disorder; Developmental Process; Disease; Distal; DNA Polymerase II; DNase I hypersensitive sites sequencing; Enhancers; Erythroblasts; Erythrocytes; Erythroid Progenitor Cells; Erythropoiesis; Event; Gene Expression; Gene Expression Profile; Gene Targeting; Genes; Genetic Transcription; Genome; genome-wide; Genomics; Heart; Hematopoietic Neoplasms; Hematopoietic stem cells; Human; human disease; human stem cells; Imagery; in vivo; inhibitor/antagonist; Knowledge; Malignant Neoplasms; Maps; Measures; Monitor; novel; Nucleic Acid Regulatory Sequences; Nucleotides; Oncogenes; One-Step dentin bonding system; Organism; Play; Process; promoter; Protein Family; Proteins; Regulatory Element; Research; Resolution; RNA; Role; System; Technology; Time; TimeLine; Transcript; Transcription Elongation; Transcription Initiation; Transcriptional Regulation; Untranslated RNA; ,"Discovering the regulatory roles of transcription during erythropoiesis, one nucleotide at a time",125238,ZRG1,Special Emphasis Panel ,,,1,57396,,57396,
9395514,F32,GM,1,N,7/12/2017,10/1/2017,9/30/2018,859,F32GM122250,SCHOOLS OF ARTS AND SCIENCES,PA-16-307,1F32GM122250-01A1,NIGMS:57066\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DURHAM,UNITED STATES,BIOLOGY,1,44387793,US,2221101,DUKE UNIVERSITY,NC,277054673,"Project Narrative Transfer RNA (tRNA) are a key component of the basic genetic mechanism of translation. High-throughput next- generation sequencing has advanced the understanding of nucleic acids tremendously, the exception to this has been tRNA, due to its complex secondary structure and degree of chemical modification. This project will utilize recent breakthrough methodology to perform the first-ever genome-wide analysis of tRNA dynamics in a plant system, and in doing so explore the role these small RNAs play in translational regulation of the plant immune response.",14460355; ,"ZWACK, PAUL J;","WILLIS, KRISTINE AMALEE",10/1/2017,9/30/2019,Amino Acid Sequence; Amino Acids; antimicrobial; Apoptosis; Arabidopsis; Area; base; Base Pairing; Biochemical; Biological Process; Cancer Biology; Cell physiology; Cell surface; Cells; Charge; Chemicals; Codon Nucleotides; comparative; Complex; cytochrome c; defense response; detection of nutrient; DNA; Down-Regulation; Gene Expression; gene induction; gene product; gene repression; Genes; Genetic; genetic information; Genetic Screening; Genetic Transcription; genome-wide; genome-wide analysis; Growth; High-Throughput Nucleotide Sequencing; Homologous Gene; Human Pathology; Hybrids; Immune; Immune response; Immunity; Immunocompetent; Impairment; Individual; Infection; interest; Laboratories; Link; Mammals; Messenger RNA; Methodology; Methods; Modification; Molecular; Molecular Biology; mutant; Mutation; next generation sequencing; novel; novel strategies; Nucleic Acids; Nucleotides; Open Reading Frames; Organism; Orthologous Gene; Output; pathogen; Pathogenesis; Pattern; Pattern recognition receptor; Peptide Initiation Factors; Peptides; Phenylalanine-Specific tRNA; Phosphorylation; Plants; Play; polypeptide; prevent; Process; Protein Biosynthesis; Proteins; Regulation; Resolution; response; Ribosomes; RNA; RNA Decay; RNA Sequences; Role; Signal Transduction; Small RNA; Specificity; Structure; System; Techniques; Testing; Transcript; transcription factor; Transfer RNA; Transfer RNA Aminoacylation; Translational Regulation; translational study; Translations; Triplet Multiple Birth; virtual; Work; Yeasts; ,Characterization of the Arabidopsis tRNAome in Pathogen Triggered Immunity,122250,ZRG1,Special Emphasis Panel ,,A1,1,57066,,57066,
9396035,F31,CA,1,N,7/26/2017,8/1/2017,7/31/2018,398,F31CA221066,SCHOOLS OF MEDICINE,PA-16-308,1F31CA221066-01,NCI:31793\,"TRAINING, INDIVIDUAL",2017,NATIONAL CANCER INSTITUTE,,ANN ARBOR,UNITED STATES,SURGERY,12,73133571,US,1506502,UNIVERSITY OF MICHIGAN,MI,481091276,"Project Narrative Fibroblasts form the support structure of organs and tissue, but in the context of disease, such as pancreatic cancer, they proliferate into a dense, lattice-like microenvironment that can affect the vascular and organ function. Fibroblasts are a heterogeneous population that are poorly understood and characterized: here we propose to study the role of a specific population of Hoxb6-expressing pancreatic fibroblasts in pancreatic cancer, with the ultimate goal to identify new therapeutic approaches for this deadly disease.",14809306; ,"GARCIA, PALOMA ELIZABETH;","MCNEIL, NICOLE E",8/1/2017,7/31/2019,Ablation; Adult; Affect; Agreement; anticancer research; base; Biological; Biological Assay; Biology; Blood Vessels; Cancer Cell Growth; Cancer Etiology; carcinogenesis; Cell physiology; Cells; Cessation of life; chemokine; chemotherapy; Collaborations; cytokine; Data; Desmoplastic; diphtheria toxin receptor; Disease; Effectiveness; Elements; Endothelial Cells; Enterobacteria phage P1 Cre recombinase; experimental study; Extracellular Matrix; Fibroblasts; Flow Cytometry; Genetically Engineered Mouse; Goals; Growth; Growth Factor; Heterogeneity; Homeobox; Immune; improved; Infiltration; Injectable; Label; Malignant neoplasm of pancreas; Malignant Neoplasms; Measures; Modeling; Morbidity - disease rate; mouse model; Mus; neoplastic; neoplastic cell; novel; novel therapeutic intervention; novel therapeutics; Organ; Pancreas; Patients; Perfusion; Pharmaceutical Preparations; Pilot Projects; Population; Population Heterogeneity; Positioning Attribute; Primary Cell Cultures; Production; Proliferating; promoter; Public Health; recombinase; Refractory; Reporter; Research; response; Role; Solid Neoplasm; stellate cell; Structure; Target Populations; targeted treatment; Testing; Therapeutic; Tissues; tool; transcription factor; Transgenic Organisms; tumor; tumor growth; tumor microenvironment; tumor progression; ,Examining the Heterogeneity of Fibroblasts in the Pancreatic Microenvironment,221066,ZRG1,Special Emphasis Panel ,,,1,31793,,31793,
9397362,F32,GM,1,N,8/25/2017,9/16/2017,9/15/2018,859,F32GM122419,ORGANIZED RESEARCH UNITS,PA-16-307,1F32GM122419-01A1,NIGMS:57066\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EUGENE,UNITED STATES,BIOLOGY,4,079289626; 948117312,US,6297005,UNIVERSITY OF OREGON,OR,974035219,"PROJECT NARRATIVE  Animals evolved in a microbial world, and must therefore be able to coexist with beneficial microbes while simultaneously identifying invaders; if the interactions between hosts and their associated microbes are not successful there can be a wide range of detrimental effects that can lead to disease. Currently, little is known about how variation in host genetics, diets, and environments can affect interactions with an individual's microbiome. Utilizing Systems Genetic approaches in the outbred fish model stickleback, I aim to identify and map immune genes involved in these host-microbe interactions, adding to our understanding of this relationship, how it is successful in creating health, and why it sometimes goes awry, resulting in disease.",14464642; ,"BECK, EMILY A;","MELILLO, AMANDA A",9/16/2017,9/15/2019,Adaptive Immune System; Affect; Alleles; Animals; base; Binding; Biological Assay; Biological Process; Chromosome Mapping; CRISPR/Cas technology; Crohn's disease; Data; Diabetes Mellitus; Diet; Disease; DNA; DNA sequencing; Environment; experimental study; Family; Fishes; Fresh Water; Gardenal; Gasterosteidae; Gene Expression; Genes; Genetic; genetic analysis; genetic approach; genetic manipulation; Genetic Transcription; genetic variant; Genetic Variation; Genomics; Genotype; Goals; gut microbiota; Health; host-microbe interactions; Human; human disease; Immune; immune function; Immune response; Immune Response Genes; Immune system; Immune Targeting; Immunity; Individual; Inflammatory Bowel Diseases; knockout gene; Knowledge; Laboratories; Lead; Location; Maps; Marines; Measures; member; Methods; Microbe; microbial; microbial community; microbiome; microbiota; Mitogen-Activated Protein Kinases; Modeling; Mutation; neutrophil; Neutrophil Infiltration; novel; Obesity; Organism; Outcome Measure; Pathway interactions; Phenotype; Play; Population; Quantitative Trait Loci; Recombinants; Research; Research Design; response; Role; Structure; System; Technology; Testing; Tissues; transcriptome sequencing; Variant; Vertebrates; Work; ,Systems genetics analysis of natural variation in threespine stickleback host immunity and microbiota,122419,ZRG1,Special Emphasis Panel ,,A1,1,57066,,57066,
9400980,F31,MH,1,N,9/15/2017,9/16/2017,9/15/2018,242,F31MH114528,SCHOOLS OF MEDICINE,PA-16-308,1F31MH114528-01,NIMH:44044\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF MENTAL HEALTH,,PHILADELPHIA,UNITED STATES,NONE,2,42250712,US,6463801,UNIVERSITY OF PENNSYLVANIA,PA,191046205,"Project Narrative Autism spectrum disorders (ASD) describe a range of conditions of neurodevelopmental origin, characterized by multiple symptom domains including impaired social interaction, deficits in communication, restrictive, repetitive patterns of interest and behavior and more recently by abnormalities in goal-directed decision making and reward prediction. Despite recent advances in ASD genetic association studies, the specific circuit dysfunctions that serve as neurobiological substrates for ASD remain largely unknown. In this proposal, we seek to identify specific neural circuit loci in which insult to a high-risk ASD gene, Neurexin1?, can drive abnormalities in goal-directed action selection. 2",11942627; ,"ALABI, OPEYEMI ;","DESMOND, NANCY L",9/16/2017,9/15/2019,Acute; autism spectrum disorder; Autistic Disorder; Basal Ganglia; base; Behavior; Behavior Disorders; Behavioral; Behavioral Paradigm; behavioral response; Binding Proteins; Cell Adhesion Molecules; Cell Surface Proteins; Choice Behavior; Code; Cognitive; Communication; Complex; Copy Number Polymorphism; Corpus striatum structure; cost; Costs and Benefits; Data; Decision Making; Defect; design; Development; DNA Sequence Alteration; early childhood; Enterobacteria phage P1 Cre recombinase; Environment; Exhibits; experimental study; flexibility; Foundations; Functional disorder; Gap Junctions; Genes; Genetic; genetic association; Genetic Predisposition to Disease; Genomics; Goals; high risk; Impairment; Induced Mutation; Inherited; Injectable; interest; Knock-out; Knockout Mice; Lead; Logistic Models; loss of function; Maps; Measures; Mediating; Modeling; Molecular; Molecular Target; Motor; motor control; Motor output; mouse model; Mus; mutant; Mutant Strains Mice; Mutation; neural circuit; Neurobiology; Neurodevelopmental Disorder; Neurons; neuropsychiatric disorder; Neurosciences; Nucleus Accumbens; Outcome; Output; Pathology; Pathway interactions; Pattern; Phenotype; Play; Population; Population Projection; postsynaptic; preference; presynaptic; promoter; Property; Recording of previous events; relating to nervous system; repetitive behavior; response; retrograde transport; reward processing; Rewards; Risk; Role; Shapes; Site; social; Social Behavior; Social Interaction; Structure; Sum; Symptoms; Synapses; Testing; Thalamic structure; theories; training opportunity; Virus; ,Localizing Abnormalities in Goal-Directed Behavior to Striatal Circuits in the Neurexin1? Mouse Model,114528,ZRG1,Special Emphasis Panel ,,,1,44044,,44044,
9405814,I01,VA,5,N,10/16/2017,10/1/2017,9/30/2018,999,I01RX001183,,RFA-RX-13-001,5I01RX001183-04,,Non-SBIR/STTR RPGs,2017,Veterans Affairs,,SEATTLE,UNITED STATES,,9,20232971,US,481094,VA PUGET SOUND HEALTHCARE SYSTEM,WA,981081532,"PUBLIC HEALTH RELEVANCE:      The World Health Organization has deemed stroke a worldwide health problem based upon its high prevalence, associated disability, and the burden it places on the individual, community and society (Janca et al, 2000). A common sequelae of left-hemisphere stroke is a language disorder called aphasia. Currently, the behavioral rehabilitation of aphasia is unsatisfactory and this proposal seeks to further develop an aphasia treatment that has high potential for improving the daily communicative lives of stroke patients.",8274680; ,"KENDALL, DIANE L.;",,10/1/2014,9/30/2018,Acquired Aphasia; Address; Adult; Aftercare; Anomia; Aphasia; aphasia rehabilitation; base; Behavioral; Child; Chronic; Communication; Communities; control trial; Controlled Study; Data; disability burden; dosage; Educational Background; efficacy testing; Evidence based treatment; Exhibits; Foundations; Goals; Growth; Health; High Prevalence; Hour; Impairment; improved; Individual; Knowledge; Language; Language Development; Language Disorders; Language Therapy; Lead; Left; lexical; Linguistics; Measures; Modeling; Names; Neural Network Simulation; Patients; Performance; Persons; Phase; phase II trial; phase III trial; phonology; predicting response; predictive modeling; Production; prospective; public health relevance; Quality Indicator; Quality of life; Rehabilitation therapy; relating to nervous system; Research; Retrieval; Sampling; Semantics; Series; Severities; Societies; sound; Speech; stroke; Testing; theories; Time; Training; treatment effect; treatment group; Treatment outcome; treatment program; treatment response; Vocabulary; World Health Organization; ,"A Prospective, Controlled Study of Rehabilitation of Anomia in Aphasia",1183,RRD3,Sensory Systems/Communication Disorders ,,,4,,,,
9470399,F32,GM,1,N,9/20/2017,10/1/2017,9/30/2018,859,F32GM125228,SCHOOLS OF ARTS AND SCIENCES,PA-16-307,1F32GM125228-01A1,NIGMS:57066\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,UNIVERSITY PARK,UNITED STATES,SOCIAL SCIENCES,5,3403953,US,1524202,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,PA,168027000,"PROJECT NARRATIVE Our investigation of the cellular underpinnings of height variation using a natural human model for small body size and short stature will generate fundamental knowledge about growth pathways in populations often overlooked in clinical research. The chondrocyte response to growth factors is under-characterized, but the use of recently developed iPSC technology makes it possible to experimentally manipulate human cells underlying stature using a powerful in vitro system and identify differential response to the growth factors between populations. Through comparisons between a rainforest hunter-gatherer (RHG) population with genetically-mediated short stature (the pygmy phenotype) and a neighboring human population with typical stature with two non-human primate species, we will identify both divergent and constrained portions of the growth factor regulatory response, with the former important in understanding RHG small body size evolution and the latter of interest to help identify genes for which regulatory disruptions would likely lead to a disease phenotype in all humans.",12504037; ,"BERGEY, CHRISTINA MARIE;","MELILLO, AMANDA A",10/1/2017,9/30/2019,African; base; Biology; Body Size; career; Categories; Cell model; cell type; Cells; Characteristics; Chondrocytes; Clinical Research; clinically significant; comparative; comparative genomics; Data; Data Set; Databases; differential expression; disease phenotype; Elements; Etiology; Evolution; experimental study; Fellowship; Fibrinogen; Fibroblast Growth Factor; forest; functional genomics; Gene Expression; Genes; Genetic; Genetic study; Genetic Variation; Genome; genome wide association study; genome-wide; Genomic approach; genomic data; Genomic Segment; Genomics; GH1 gene; Goals; Growth; Growth and Development function; Growth Factor; growth hormone deficiency; Health; Height; Human; Hypothyroidism; In Vitro; induced pluripotent stem cell; insight; Insulin-Like Growth Factor I; interest; Investigation; Knockout Mice; Knowledge; Lead; male; Malnutrition; Mediating; Methods; Modeling; Molecular; National Research Service Awards; Natural Selections; nonhuman primate; Pan Genus; Papio; Pathologic; Pathway interactions; Patients; Phenotype; Play; Population; post-doctoral training; Primates; Process; Rain; Regulator Genes; Research Personnel; response; Role; Sampling; SNP genotyping; Somatomedins; Somatotropin; Study models; System; Technology; Testing; Training; trait; transcriptome sequencing; Turner's Syndrome; Tweens; Uganda; United States National Institutes of Health; Variant; Work; ,Functional genomics of growth hormone response in a natural human model for short stature with comparisons to other populations and species,125228,ZRG1,Special Emphasis Panel ,,A1,1,57066,,57066,
9470831,F32,GM,1,N,9/8/2017,9/29/2017,9/28/2018,859,F32GM125231,SCHOOLS OF ARTS AND SCIENCES,PA-16-307,1F32GM125231-01A1,NIGMS:56694\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PASADENA,UNITED STATES,NONE,29,9584210,US,1073501,CALIFORNIA INSTITUTE OF TECHNOLOGY,CA,911250001,"Project Narrative  The very broad biomedical applications of organoboron compounds necessitates the development of new methods for introducing boron into molecules with high efficiency and selectivity. The proposed research will develop the first enzymes that can effect the enantioselective formation of C-B bonds. This biocatalyst would enable highly efficient and enantioselective synthetic routes to a variety of functional organoboron compounds, such as ?-aminoboronic acids, an important motif in numerous drug candidates.",14806276; ,"HUANG, XIONGYI ;","LEES, ROBERT G",9/29/2017,9/28/2019,Acids; Active Sites; Advanced Development; analog; base; Benign; Biochemical; Biological; Biology; Boranes; Boron; Boronic Acids; cancer therapy; carbene; Carbon; catalyst; Chemicals; Collection; Crystallization; cytochrome c; Cytochromes; Development; diazo compound; Directed Molecular Evolution; drug candidate; Enzymes; Hemeproteins; Hydrogen Bonding; improved; inhibitor/antagonist; insight; Iron; Isotopes; Kinetics; Knowledge; Measures; Medicine; Methodology; Methods; Modeling; Molecular; mutant; Mutation; Organic Synthesis; Prevalence; Proteins; Reaction; Research; Rhodothermus; Route; Scheme; screening; Series; Solvents; Specificity; Structure; System; Testing; Variant; Walking; X-Ray Crystallography; ,A Biocatalytic System for Enantioselective Carbon-Boron Bond Formation,125231,ZRG1,Special Emphasis Panel ,,A1,1,56694,,56694,
9573363,U01,EB,3,N,10/19/2017,10/19/2017,6/30/2018,310,U01EB023686,SCHOOLS OF ARTS AND SCIENCES,PA-16-287,3U01EB023686-02S1,OD:2177\,Non-SBIR/STTR RPGs,2018,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,3,43207562,US,9420201,YALE UNIVERSITY,CT,65208327,,6378681; ,"GERSTEIN, MARK BENDER;","RAMOS, EDWARD",9/23/2016,6/30/2018,abstracting; Algorithms; analytical tool; Attention; Awareness; Cancerous; Cells; Characteristics; ChIP-seq; Computer software; Consent; Data; data access; data mining; Data Set; Disease; DNA; DNA sequencing; endophenotype; experimental study; Extravasation; Family member; file format; functional genomics; Future; Gene Expression; Gene Expression Profiling; Genes; Genetic Transcription; genetic variant; Genome; genomic data; genomic tools; Genomics; Genotype; Genotype-Tissue Expression Project; Glean; Goals; graduate student; Individual; Intuition; Link; Literature; Malignant Neoplasms; Mathematics; Mediating; Medical Research; Methodological Studies; Methodology; Methods; Modeling; molecular phenotype; patient privacy; Peripheral; Phenotype; Predisposition; Privacy; Privatization; Quantitative Trait Loci; Research; Research Personnel; Risk; Risk Management; RNA Splicing; sharing data; software development; Software Tools; Source; Structure; Techniques; The Cancer Genome Atlas; Time; tool; Transcript; transcriptome sequencing; Untranslated RNA; Variant; Work; ,Methods and Software to Enhance Genomic Privacy and Sharing of RNA-Seq Data,23686,,,,S1,2,1300,877,2177,
9396768,F32,DE,1,N,5/26/2017,7/1/2017,6/30/2018,121,F32DE027269,SCHOOLS OF DENTISTRY/ORAL HYGN,PA-16-307,1F32DE027269-01,NIDCR:59966\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,NEW YORK,UNITED STATES,DENTISTRY,12,41968306,US,5998301,NEW YORK UNIVERSITY,NY,100122300,"PROJECT NARRATIVE The incidence of oral cancer is increasing, particularly among young people and women and, while most patients suffer from severe, chronic pain, women report more pain than men. Opioid drugs do not effectively alleviate the pain. The proposed studies, focused on the differing roles of immune cells in the cancer environment in males and females have the potential to lead to development of novel therapeutic approaches for the treatment of pain.",11641494; ,"SCHEFF, NICOLE N;","FRIEDEN, LESLIE A",7/1/2017,6/30/2019,4-Nitroquinoline-1-oxide; Afferent Neurons; Analgesics; Area; Automobile Driving; base; Cancer Center; cancer pain; Cancer Patient; carcinogenesis; career; Cells; chronic pain; Clinical; Clinical Research; cohort; Consent; Data; Development; Eligibility Determination; Enrollment; Environment; Etiology; Evaluation; Exhibits; experience; experimental study; Female; Flow Cytometry; Goals; Histopathology; Home environment; Human; Immune; Immune response; Incidence; Infiltration; Inflammation; Inflammatory; Inflammatory Infiltrate; injured; Injury; Investigation; Knowledge; Lead; male; malignant mouth neoplasm; Malignant Neoplasms; malignant tongue neoplasm; Measures; Mechanics; Mediating; men; Modeling; mouse model; mouth squamous cell carcinoma; Mus; Naloxone; Neurobiology; neutrophil; Neutrophil Infiltration; Nociception; novel therapeutic intervention; Operative Surgical Procedures; Opioid; Opioid Peptide; Opioid Receptor; Oral; oral carcinogenesis; oral pain; Pain; pain behavior; Pain management; Pathologic; Pathology Report; Patient Recruitments; Patient Self-Report; Patients; Pharmaceutical Preparations; Prevalence; Questionnaires; Reporting; response; Role; screening; Severities; sex; Sex Characteristics; skill acquisition; Specimen; study population; Testing; Tissues; Tongue; Training; Translational Research; translational research program; Trigeminal System; tumor; tumor microenvironment; Woman; ,Does Neutrophil Infiltrate Impact Oral Cancer Pain,27269,DSR,NIDR Special Grants Review Committee ,,,1,59966,,59966,
9470327,F30,DC,1,N,8/18/2017,8/22/2017,8/21/2018,173,F30DC016806,SCHOOLS OF MEDICINE,PA-16-305,1F30DC016806-01,NIDCD:31485\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CHARLOTTESVILLE,UNITED STATES,NEUROSCIENCES,5,65391526,US,1526402,UNIVERSITY OF VIRGINIA,VA,229044195,Project Narrative This research will test the hypothesis that mechanical signals are a prominent mediator of regeneration of sensory hair cells in the inner ear. It will also reveal candidate genes which may limit regeneration in mature mammals by impeding such signals. This ultimately could lead to therapies which ameliorate the irreversible hearing and balance deficits afflicting millions of Americans.,12315066; ,"RUDOLF, MARK ALEXANDER;","RIVERA-RENTAS, ALBERTO L",8/22/2017,8/21/2020,Ablation; Actins; Affinity; American; Apical; Candidate Disease Gene; cell behavior; Cell Death; Cell Nucleus; Cell Proliferation; Cell Shape; cell type; Cells; Cessation of life; Chickens; covalent bond; CRISPR/Cas technology; crosslink; Crosslinker; Cues; Development; Epithelial Cells; Epithelium; Equilibrium; Etiology; Event; Exhibits; F-Actin; Genes; Growth; hair cell regeneration; Hair Cells; Hearing; hearing impairment; Human; improved; in vivo; Incidence; knock-down; Knock-out; Labyrinth; Lasers; Lead; Lifting; Light; Maintenance; Mammals; Mass Spectrum Analysis; Measures; mechanical force; Mechanics; Mediating; Mediator of activation protein; Mitosis; mouse model; Mus; Natural regeneration; Neonatal; Nuclear Translocation; Optics; optogenetics; Organ; paralogous gene; Pathway interactions; Peptides; Phenotype; postnatal; Process; Proliferating; Proteins; Proteome; regenerative; Regenerative response; repaired; Research; Role; S Phase; Sensory; Sensory Hair; Signal Transduction; Staining method; Stains; Streptomycin; Stretching; Subcellular structure; Supporting Cell; Surface; Surveys; Techniques; Testing; Thick; Time; tissue regeneration; transcription factor; transdifferentiation; transmission process; two-photon; uptake; Utricle structure; Vertebrates; ,Sensory Hair Cell Regeneration: Tests of Hypothesized 'Triggers' and 'Brakes',16806,ZDC1,Special Emphasis Panel ,,,1,31485,,31485,
9567943,I21,VA,5,N,10/19/2017,6/1/2017,2/28/2018,999,I21RX001734,,RFA-RX-14-009,5I21RX001734-03,,RESEARCH CENTERS,2018,Veterans Affairs,,BRONX,UNITED STATES,,13,40077133,US,481060,JAMES J PETERS VA  MEDICAL CENTER,NY,104683904,"The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia. Subnormal Tcore and vulnerablility to hypothermia have been reported with exposure to cool environmental temperatures in veterans with tetraplegia. Despite the known deficits in the ability of persons with SCI to maintain Tcore, and the effects of hypothermia to impair mental function in able-bodied persons, no work to date has addressed these issues in persons with tetraplegia. Our preliminary findings in persons with SCI suggest a decline in Tcore after cool exposure was associated with a decline in cognitive functioning, while an increase in subnormal Tcore to normal values after warm exposure appears to improve cognitive functioning. Our proposed study will confirm and extend our intial observations in persons with SCI who have subnormal Tcore to show that cognitive function will indeed be improved by raising Tcore to normal, which should be associated with greater function and independence, reintegration into society, and an improved quality of life.",9718950; ,"HANDRAKIS, JOHN P;",,6/1/2015,2/28/2018,Activities of Daily Living; Address; Adverse effects; Age; Arrhythmia; Attention; Awareness; base; Behavior; Blood; Blood Pressure; Body Composition; Body Temperature; carbohydrate metabolism; Cardiac; Centers for Disease Control and Prevention (U.S.); Cervical; Cessation of life; Chronic; Cognition; Cognitive; cognitive function; cognitive performance; Comparative Study; Confusion; Data; Depressed mood; diet and exercise; disorder prevention; Distal; Encephalopathies; Environment; Esthesia; executive function; Exposure to; Feeling; Gender; Goals; Headache; Heart Arrest; Hour; Hyperthermia; Impairment; improved; Individual; Infection; insight; instrumentation; insulin sensitivity; Interruption; Intervention; Judgment; Kidney Failure; Knowledge; lean body mass; Lesion; Limb structure; Liver Failure; Maintenance; Measurement; Measures; Medical; Mental Depression; mental function; metabolic rate; Methodology; Motor; natural hypothermia; Nausea; Normal Range; Pain; Paraplegia; Pathway interactions; Peripheral; Persons; Pharmaceutical Preparations; Physiologic Thermoregulation; Physiological; Pilot Projects; Positioning Attribute; processing speed; prospective; Quadriplegia; Quality of life; Recruitment Activity; rectal; Reporting; Research; response; Risk; safety study; Sensory; Shivering; Short-Term Memory; Signs and Symptoms; Skin; Skin Temperature; Societies; sound; Spastic; spasticity; Spinal cord injury; Stupor; Sunlight; Sweat; Sweating; Temperature; therapy development; thermal stress; Thermogenesis; Thoracic Injuries; Time; Unconscious State; vasoconstriction; Vasodilation; Ventricular Fibrillation; Veterans; Viscosity; warm temperature; Work; ,Effect of Heat Exposure on Cognition in Persons with Higher Cord Lesions,1734,RRDS,Rehabilitation Research and Development SPiRE Program ,,,3,,,,
9573850,U01,EB,3,N,10/19/2017,10/19/2017,6/30/2018,310,U01EB023685,SCHOOLS OF ARTS AND SCIENCES,PA-16-287,3U01EB023685-02S1,OD:3780\,Non-SBIR/STTR RPGs,2018,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,BLOOMINGTON,UNITED STATES,MISCELLANEOUS,9,6046700,US,577805,INDIANA UNIVERSITY BLOOMINGTON,IN,474013654,"We propose to develop encryption methods for biomedical data mining, and to implement these methods in open-source software that can be used by biomedical researchers in a plug-and- play manner for the statistical analysis of encrypted biomedical data. Following our approach, biomedical data will be protected by encryption once they are generated, and the subsequent analysis and sharing will always be performed on the encrypted form, which thus can achieve a high security standard for privacy protection in biomedical data science.",8366781 (contact); 9020575; ,"TANG, HAIXU T. (contact); WANG, XIAOFENG ;","RAMOS, EDWARD",9/30/2016,6/30/2018,Algorithms; Awareness; base; Beavers; big biomedical data; Big Data; Biomedical Computing; biomedical informatics; Biomedical Research; Collaborations; Collection; Computer software; cryptography; Custom; Data; data mining; Data Science; Development; Devices; Diagnostic; Dimensions; Electronic Health Record; encryption; Ensure; Foundations; genome analysis; Genomics; Heterogeneity; high dimensionality; high risk; Human; Human Genome; Image; improved; indexing; individual patient; Information Technology; Institution; Lead; Libraries; Measures; Medical Imaging; Methods; mHealth; Mining; multidisciplinary; next generation sequencing; novel; open source; Outsourcing; Patients; Performance; personalized medicine; Play; Precision Medicine Initiative; Privacy; privacy protection; prospective; Protocols documentation; prototype; Research Personnel; Science; Secure; Security; software development; Software Tools; Statistical Algorithm; Statistical Data Interpretation; Suggestion; Techniques; Testing; Therapeutic; tool; usability; vector; ,Encryption methods and software for privacy-preserving analysis of biomedical data,23685,,,,S1,2,2400,1380,3780,
9589589,Y01,DA,,N,,,,,Y01DA150010,,,ADA15001001-1-0-1,NIDA:400000\,INTERAGENCY AGREEMENTS,2017,NATIONAL INSTITUTE ON DRUG ABUSE,,,,,,,,,NATIONAL INSTITUTE ON DRUG ABUSE,,,,; ,",  ;",,,,,VA Health Care Systems,,,,,,,,,400000,
9204210,P01,DK,2,N,10/19/2017,5/15/2017,4/30/2018,,P01DK056492,,PAR-13-266,2P01DK056492-17A1,NIDDK:159476\,Non-SBIR/STTR RPGs,2017,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,HOUSTON,UNITED STATES,,9,51113330,US,481201,BAYLOR COLLEGE OF MEDICINE,TX,770303411,"NARRATIVE The proposed research has important implications for the health of individuals living with chronic HIV infection. The Clinical Core will support research to characterize the contribution of chronic HIV infection to the increased risk of kidney disease in HIV infected individuals. This research will be particularly relevant to African- Americans, who have a disproportionate burden of both HIV infection and chronic kidney disease.",8645979; ,"WYATT, CHRISTINA M;",,,,Acetylation; African American; AIDS-Associated Nephropathy; antiretroviral therapy; Archives; Bioinformatics; Biopsy; Blood; Cell Line; Chronic; Chronic Kidney Failure; Clinical; Clinical Data; Clinical Research; Consequences of HIV; Data; Databases; Development; Diabetic mouse; disorder risk; End stage renal failure; Enrollment; Ensure; Epidemiology; Epithelial Cells; Feces; Gene Expression; gut microbiota; Health; high risk; Histologic; Histology; Histopathology; HIV; HIV Infections; Human; human subject; immortalized cell; Immune response; In Vitro; Individual; Inflammatory; inflammatory marker; Injury; Kidney; Kidney Diseases; Laboratories; Laboratory Finding; Life Cycle Stages; Link; Logistics; microbiome; Mitochondria; mouse model; Natural History; Nephrology; nephrotoxicity; Participant; Pathogenesis; Pathway interactions; Patients; Pattern; Process; programs; prospective; Protocols documentation; Recruitment Activity; Research; Research Design; Research Personnel; Research Support; Resources; Risk; Role; senescence; SIRT1 gene; Specimen; Standardization; synergism; Tissues; transcription factor; Transgenic Mice; Tubular formation; Urine; Viral; Viral reservoir; Work; ,Clinical Core (MSSM),56492,ZDK1,Special Emphasis Panel ,7985,A1,17,94086,65390,,159476
9395602,F32,HD,1,N,8/4/2017,8/7/2017,8/6/2018,865,F32HD093282,ORGANIZED RESEARCH UNITS,PA-16-307,1F32HD093282-01,NICHD:59033\,"TRAINING, INDIVIDUAL",2017,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BATON ROUGE,UNITED STATES,NONE,6,611012324,US,577909,LSU PENNINGTON BIOMEDICAL RESEARCH CTR,LA,708084124,"PROJECT NARRATIVE  Play is so fundamental to optimal child development that it has been recognized as a right of every child by the United Nations Commission on Human Rights. Yet, opportunities for outdoor play in modern society are limited, especially within disadvantaged neighborhoods. The proposed research will employ a mixed methods approach to generate a comprehensive understanding of how and which environmental factors play a role in parental constraint of youth outdoor play and promote low levels of within-neighborhood physical activity. Knowledge gained from the proposed study will inform community-based interventions that target neighborhood factors in an effort to reduce parental constraints on outdoor play and increase physical activity during critical years of development.",14805562; ,"KEPPER, MAURA ;","ESPOSITO, LAYLA E",8/7/2017,8/6/2019,16 year old; Accelerometer; Adolescence; Adolescent; African American; Area; base; Behavior; boys; career; career development; Caucasians; Child; Child Development; Child Rearing; Childhood; cohesion; cohort; Communities; Complex; Crime; Dangerousness; Data; Development; Doctor of Philosophy; Emotional; Environment; Environmental Risk Factor; experience; Fellowship; Foundations; girls; Goals; Growth; Health; Human Rights; Intervention; Interview; Investigation; Knowledge; Learning; Link; Location; Longitudinal observational study; Measures; Mediating; Methods; Modernization; neighborhood disadvantage; Neighborhoods; offspring; parental influence; Parents; Participant; Physical activity; Physical environment; Play; Positioning Attribute; Property; Qualitative Methods; Reporting; Research; Research Methodology; Research Personnel; Research Proposals; Research Training; Role; Security Measures; skills; social; Social Environment; Societies; System; Technology; Time; Training; Translating; United Nations; virtual; Youth; ,"?Neighborhood Influence, Parenting Practices, and Youth Physical Activity.?",93282,ZRG1,Special Emphasis Panel ,,,1,59033,,59033,
9453242,F32,MH,1,N,9/15/2017,10/1/2017,9/30/2018,242,F32MH115416,GRADUATE SCHOOLS,RFA-MH-17-250,1F32MH115416-01,NINDS:61694\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF MENTAL HEALTH,,PRINCETON,UNITED STATES,NEUROSCIENCES,12,2484665,US,6661401,PRINCETON UNIVERSITY,NJ,85430036,"Project Narrative The ability to appropriately accumulate evidence during decision-making is an essential cognitive ability in humans, and it is disrupted in a number of mental diseases. This project aims to understand the neural mechanisms that underlie the capacity to accumulate evidence during decision-making. To do so, it will characterize the interactions between brain areas implicated in decision-making through optogenetic perturbation and electrophysiological single-neuron recording across multiple brain areas.",11165701; ,"LUO, ZHIHAO ;","DESMOND, NANCY L",10/1/2017,9/30/2020,Address; Animals; Area; Auditory; Basal Ganglia; base; Behavior; Brain; Categories; Cell Nucleus; Cognitive; cognitive ability; Corpus striatum structure; Decision Making; Disease; Electrophysiology (science); experimental study; Eye Movements; frontal lobe; Human; Impairment; Modeling; Movement; neural circuit; neuromechanism; Neurons; nonhuman primate; optogenetics; Output; Pathway interactions; Performance; Psyche structure; Rattus; relating to nervous system; Rodent; Role; sample fixation; Structure; Substantia nigra structure; superior colliculus Corpora quadrigemina; Task Performances; Time; Work; ,Circuit mechanisms of evidence accumulation during decision-making,115416,ZMH1,Special Emphasis Panel ,,,1,61694,,61694,
9464749,F30,MH,1,N,9/11/2017,9/29/2017,9/28/2018,242,F30MH115517,SCHOOLS OF MEDICINE,PA-16-305,1F30MH115517-01,NIMH:49044\,"TRAINING, INDIVIDUAL",2017,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,4514360,US,2059802,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,PA,152132303,"PROJECT NARRATIVE Obsessive compulsive disorder (OCD) is a debilitating psychiatric disorder with inadequate treatment options. There is evidence for a genetic component in the etiology of OCD, with the gene SLC1A1, which codes for the neuronal glutamate transporter, being the most commonly implicated gene. This proposal will characterize the role of this gene in OCD-like behavior in mice.",11886492; ,"KOPELMAN, JARED MICHAEL;","VAN'T VEER, ASHLEE V",9/29/2017,9/28/2020,9p24; Ablation; Acute; Adult; Affect; Agonist; Alleles; Amphetamines; anxiety-like behavior; Attenuated; Autistic Disorder; Autopsy; Behavior; Behavioral; behavioral response; Biological Assay; Brain; Brain region; Breeding; calmodulin-dependent protein kinase II; Cells; Chromosomes; Chronic; Code; Complex; Compulsive Behavior; Corpus striatum structure; Data; Development; Dopamine D1 Receptor; EAAT3; Etiology; Family Study; Generations; Genes; Genetic; Genetic Polymorphism; Glutamate Transporter; Glutamates; Grooming; Human; Hyperactive behavior; imaging study; Impairment; improved; in vivo calcium imaging; inhibitor/antagonist; Knock-in Mouse; Knock-out; Knockout Mice; Lead; Link; Luciferases; Medical; Mental disorders; Messenger RNA; Modeling; mouse model; Mus; Neurons; Neurosciences; Obsessive-Compulsive Disorder; overexpression; Pathogenesis; Patients; Pattern; Pharmacology; Phenotype; Population; prepulse inhibition; prevent; protein expression; protein function; Proteins; repetitive behavior; Reporter; response; Reversal Learning; Role; standard of care; stereotypy; Suggestion; Testing; tool; Transgenic Mice; Twin Studies; Up-Regulation; uptake; Western Blotting; World Health Organization; ,Examining the Role of EAAT3 in OCD-like Behavior,115517,ZRG1,Special Emphasis Panel ,,,1,49044,,49044,
9536543,Y01,DA,,N,,,,,Y01DA160020,,,ADA16002001-1-0-1,NIDA:120000\,INTERAGENCY AGREEMENTS,2017,NATIONAL INSTITUTE ON DRUG ABUSE,,,,,,,,,NATIONAL INSTITUTE ON DRUG ABUSE,,,,; ,",  ;",,,,addiction; computational toxicology; Computer software; Congresses; Development; Drug Addiction; drug discovery; Evaluation; Goals; improved; interest; Meta-Analysis; Modeling; National Institute of Drug Abuse; Pharmaceutical Preparations; Pharmacologic Substance; programs; Research; Services; Therapeutic; Tobacco; Toxicology; United States National Institutes of Health; Validation; ,FDA Toxicology IAA ,,,,,,,,,120000,
9568061,R01,DA,7,N,10/19/2017,9/1/2017,3/31/2018,279,R01DA025537,SCHOOLS OF PUBLIC HEALTH,PA-12-111,7R01DA025537-10,NIDA:290270\,Non-SBIR/STTR RPGs,2017,NATIONAL INSTITUTE ON DRUG ABUSE,,PISCATAWAY,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,6,78795880,US,10034175,RBHS-SCHOOL OF PUBLIC HEALTH,NJ,88548021,"PUBLIC HEALTH RELEVANCE: The goal of this project is to understand why a new generation of YMSM place themselves at risk for HIV transmission. We seek to understand why some men exhibit risky behaviors as they emerge into adulthood while others do not. Working with community and municipal partners, we will draw from what we have learned from both groups to develop strategies for HIV prevention and intervention that are relevant to this current and developing generation who did not live through the devastation of the AIDS epidemic in the 1980's.",2129931; ,"HALKITIS, PERRY N;","SCHULDEN, JEFFREY D",9/1/2008,3/31/2019,19 year old; Acquired Immunodeficiency Syndrome; Adherence; Adult; Age; AIDS prevention; Anus; base; Behavior; Biological Markers; Caring; Characteristics; Chlamydia; Clinical Markers; Clinical Treatment; cohort; Cohort Studies; Communities; Complement; Complex; Data; Data Collection; density; Development; Diagnosis; emerging adulthood; Enrollment; Epidemic; Equation; Ethnic Origin; Exhibits; experience; follow-up; Generations; Goals; Gonorrhea; Growth; Health; higher education; HIV; HIV Seropositivity; Homelessness; Housing; housing instability; illicit drug use; Incidence; Individual; Institute of Medicine (U.S.); Light; low socioeconomic status; Measurement; member; men; Mental Health; Minority Groups; Modeling; Municipalities; Outcome; Participant; Pattern; Predictive Factor; Preventive Intervention; Production; Prospective cohort study; psychosocial; Psychosocial Factor; public health relevance; Publications; Publishing; Race; racial and ethnic; Recruitment Activity; rectal; Risk; Risk Behaviors; Role; Sampling; Sampling Studies; screening; Serologic tests; Sex Behavior; Sex Orientation; Sexually Transmitted Diseases; social; Social Class; social health determinants; Social support; socioeconomics; Survival Analysis; Syphilis; Testing; theories; Time; transmission process; trend; uptake; Urethra; Viral; Viral Load result; Visit; Work; young man; young men who have sex with men; ,Syndemic Production in Emergent Adult Men,25537,ZRG1,Special Emphasis Panel ,,,10,255887,34383,290270,
9589585,Y01,DA,,N,,,,,Y01DA150020,,,ADA15002003-3-0-1,NIDA:2087987\,INTERAGENCY AGREEMENTS,2017,NATIONAL INSTITUTE ON DRUG ABUSE,,,,,,,,,NATIONAL INSTITUTE ON DRUG ABUSE,,,,; ,",  ;",,,,,VA Cooperative Studies Program,,,,,,,,,2087987,