"APPLICATION_ID","ACTIVITY","ADMINISTERING_IC","APPLICATION_TYPE","ARRA_FUNDED","AWARD_NOTICE_DATE","BUDGET_START","BUDGET_END","CFDA_CODE","CORE_PROJECT_NUM","ED_INST_TYPE","FOA_NUMBER","FULL_PROJECT_NUM","FUNDING_ICs","FUNDING_MECHANISM","FY","IC_NAME","NIH_SPENDING_CATS","ORG_CITY","ORG_COUNTRY","ORG_DEPT","ORG_DISTRICT","ORG_DUNS","ORG_FIPS","ORG_IPF_CODE","ORG_NAME","ORG_STATE","ORG_ZIPCODE","PHR","PI_IDS","PI_NAMEs","PROGRAM_OFFICER_NAME","PROJECT_START","PROJECT_END","PROJECT_TERMS","PROJECT_TITLE","SERIAL_NUMBER","STUDY_SECTION","STUDY_SECTION_NAME","SUBPROJECT_ID","SUFFIX","SUPPORT_YEAR","DIRECT_COST_AMT","INDIRECT_COST_AMT","TOTAL_COST","TOTAL_COST_SUB_PROJECT"
"9736695","R01","DK","5","N","04/26/2019","04/01/2019","03/31/2020","847","R01DK117383","SCHOOLS OF MEDICINE","PA-16-188","5R01DK117383-02","NIDDK:387227\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","PITTSBURGH","UNITED STATES","ANESTHESIOLOGY","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","Public Health Relevancy Statement Interstitial cystitis/bladder pain syndrome (IC/BPS) is one of the most debilitating medical conditions affecting over 10 million people, mostly women. The proposed research will develop non- pharmacological therapy by ?implanting? surveillance receptors in the bladder to automatically adjust sensitivity to bladder pain and to serve as the ?chosen? targets for certain food metabolites that would otherwise have no pain-killing effects. This innovative research has the potential to greatly improve the clinical treatment of IC/BPS in the foreseeable future and at the same time address the widespread problem of prescription drug abuse.","2534404; ","XU, YAN ;","MULLINS, CHRISTOPHER V","07/01/2018","03/31/2023","Absence of pain sensation; Acidosis; Address; Adverse effects; Affect; afferent nerve; Agonist; Amines; Analgesics; Antidepressive Agents; base; Basic Science; Behavioral; Binding Sites; Bladder; Bladder Control; bladder pain; Bladder Tissue; Cannabinoids; Caring; Cell Culture Techniques; Cell Line; chemical genetics; Chemicals; Chlorides; chronic pain; chronic painful condition; Clinical; Clinical Research; Clinical Treatment; Cocaine; Cyclophosphamide; Data; Death Rate; Dependence; design; designer receptors exclusively activated by designer drugs; Development; Dose; Drug abuse; Drug Addiction; Drug Prescriptions; Drug Tolerance; Economics; effective therapy; Engineering; Etiology; Female; Fiber; Food; food consumption; Frequencies; Future; Gene Delivery; Gene Targeting; gene therapy; Genes; genetic technology; Goals; Heroin; Human; Hyperactive behavior; Implant; improved; improved outcome; in vivo; Inflammation; Inflammatory; inflammatory pain; Injections; innovation; Institutes; Interstitial Cystitis; Intrathecal Injections; intravesical; Intravesical Instillation; Legal patent; Ligand Binding; Ligands; Liposomes; male; Measurement; Measures; Medical; Medicine; men; Mental Health; Modeling; nanoparticle; Nerve; Nerve Tissue; Neurons; Neurotransmitters; Nociception; Nociceptors; non-Native; Non-Steroidal Anti-Inflammatory Agents; Nonpharmacologic Therapy; Opiate Addiction; Opioid; opioid overdose; optogenetics; Outcome Measure; Overdose; Pain; Pain management; Patients; Peripheral; Peripheral Nerves; Pharmaceutical Preparations; Physiological; Polyamines; prescription drug abuse; prescription opioid; pressure; Prevalence; Process; programs; Propylamines; public health relevance; Rattus; receptor; receptor expression; Recombinant adeno-associated virus (rAAV); Reporting; Research; response; Risk; sex; social; Specificity; Stretching; Structure; Technology; Testing; Therapeutic Effect; Time; Treatment Efficacy; trend; United States National Institutes of Health; Urination; Urine; Urothelial Cell; Urothelium; Woman; Xenopus oocyte; ","RELIEPH for Interstitial Cystitis","117383","SAT","Surgery, Anesthesiology and Trauma Study Section ","","","02","274417","112810","387227",""
"9759543","F31","DK","1","N","01/28/2019","04/01/2019","03/31/2020","847","F31DK121414","SCHOOLS OF MEDICINE","PA-18-671","1F31DK121414-01","NIDDK:43596\","TRAINING, INDIVIDUAL","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BIRMINGHAM","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","Project Narrative Brown adipose tissue (BAT) is an attractive target for the treatment of obesity, an ever-growing disease resulting in whole-body metabolic dysregulation. To exploit BAT energy-dissipating capacity, we need a greater understanding of transcriptional mechanisms governing tissue function. This proposed research will reveal novel transcriptional regulators required to maintain BAT function, illuminating targets that will improve obesity therapies. ! !","15127655; ","KEPPLE, JESSICA ;","CASTLE, ARTHUR","04/01/2019","03/31/2022","Address; Adipocytes; Adipose tissue; adult obesity; Affect; Agonist; Animals; base; Biology; Blood Glucose; Body Temperature; Brain; Brown Fat; Cell Line; Cell Nucleus; Cell Respiration; Cell Size; Cellular Morphology; Centers for Disease Control and Prevention (U.S.); ChIP-seq; combat; Complex; Data; Defect; design; Development; Diabetes Mellitus; dimer; Disease; Electron Transport; Energy Intake; Energy Metabolism; Enterobacteria phage P1 Cre recombinase; experimental study; Fasting; fatty acid oxidation; Fatty Acids; Feeding behaviors; Future; Gene Expression; Gene Expression Regulation; gene function; Gene Targeting; Generations; Genes; Genetic; Genetic Transcription; Genus Hippocampus; Glucose; Glucose Intolerance; glucose metabolism; glucose tolerance; Goals; Heart Diseases; Helix-Turn-Helix Motifs; Heterozygote; High Fat Diet; Histology; Homeostasis; Impairment; improved; Indirect Calorimetry; insulin signaling; insulin tolerance; intraperitoneal; Islets of Langerhans; Knockout Mice; Knowledge; LIM Domain; lipid biosynthesis; lipid metabolism; Lipids; Measurement; Measures; Mediating; Mediator of activation protein; Messenger RNA; Metabolic; Metabolic Diseases; Metabolic stress; Metabolism; Mitochondria; Mitochondrial Proteins; Monitor; Motor Activity; mouse model; Mus; novel; Obesity; obesity treatment; Oils; Outcome; Pathway interactions; Physiological; Physiology; Play; Preventive; Protein Binding Domain; Publishing; Regulator Genes; Reporter; Reporting; Research; respiratory; Role; scaffold; Sorting - Cell Movement; Stains; System; Technology; Testing; Therapeutic; Therapeutic Intervention; therapeutic target; Thermogenesis; Thinness; Time; Tissues; transcription factor; Transcriptional Regulation; transcriptome; transcriptome sequencing; uncoupling protein 1; Visual; Work; ","Illuminating novel roles for the Ldb1 co-regulator in transcriptional regulation of brown adipose function","121414","ZDK1","Special Emphasis Panel ","","","01","43596","","43596",""
"9761204","F30","HD","1","N","04/15/2019","04/01/2019","03/31/2020","865","F30HD096812","OVERALL MEDICAL","PA-18-668","1F30HD096812-01A1","NICHD:50016\","TRAINING, INDIVIDUAL","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","PORTLAND","UNITED STATES","NONE","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","Project Narrative Using a clinically relevant model of placental insufficiency in sheep, this project seeks to determine the molecular mechanisms that underlie altered cardiomyocyte fatty acid metabolism. These studies will provide insight into how the intrauterine environment sets the trajectory for cardiac and metabolic dysfunction in adulthood.","12598950; ","DRAKE, RACHEL ;","ILEKIS, JOHN V","04/01/2019","03/31/2023","acylcarnitine; Adult; Affect; Animals; Birth; BODIPY; body system; Cardiac Myocytes; cardiogenesis; Cardiovascular Diseases; cardiovascular health; Carnitine O-Palmitoyltransferase; Cause of Death; CD36 gene; Cell physiology; Cells; Cellular Membrane; Chronic Disease; clinically relevant; Confocal Microscopy; Diabetes Mellitus; Environment; Esterification; experimental study; fatty acid metabolism; fatty acid oxidation; fatty acid transport; Fatty Acids; fetal; Fetal Growth Retardation; Fetal Heart; Fetus; Fluorescence; Future; Gene Expression; Gene Proteins; Genes; Genus Hippocampus; Glucose; glucose tolerance; Goals; Growth; Heart; Heart failure; heart function; Human; Hypoglycemia; Hypoxemia; Impairment; improved; in utero; in vivo; insight; Label; Laboratory Study; Life; Lipids; live cell imaging; long chain fatty acid; Measures; Metabolic; Metabolic Diseases; Metabolic dysfunction; Metabolic Pathway; Metabolism; Mitochondria; Modeling; Molecular; Myocardial; Myocardial dysfunction; Myocardium; Nutrient; nutrition; Nutritional; Obesity; oxidation; Oxides; Oxygen; Oxygen Consumption; Palmitates; Pathway interactions; Physiological; Physiology; Placental Insufficiency; postnatal; Pregnancy; Premature Infant; prenatal stress; Preparation; prevent; Process; Production; protein expression; response; Risk; Series; Serum; Sheep; Stress Tests; Techniques; Therapeutic Embolization; therapy development; Thin Layer Chromatography; United States; uptake; ","Fetal Cardiomyocyte Fatty Acid Metabolism is impaired in Intrauterine Growth Restriction","096812","ZRG1","Special Emphasis Panel ","","A1","01","50016","","50016",""
"9779232","R01","HD","1","N","04/24/2019","04/24/2019","03/31/2020","865","R01HD096999","SCHOOLS OF PUBLIC HEALTH","PA-18-484","1R01HD096999-01A1","NICHD:767313\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","SEATTLE","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","PROJECT NARRATIVE More than one million HIV-exposed uninfected infants are born each year, and have substantially higher risk of infectious morbidity and growth faltering than HIV-unexposed uninfected infants. We propose a prospective cohort study to evaluate the association between maternal HIV infection, human milk oligosaccharide (HMO) composition, and the infant gut microbiome, and identify HMO-mediated pathways associated with morbidity and linear growth in HIV-exposed uninfected infants in Kenya. Results from this longitudinal study will provide critical data for the design of interventions to optimize growth and health outcomes in HIV-exposed uninfected children in Africa, a vulnerable and growing population.","2089719; 8012754 (contact); ","ALDROVANDI, GRACE M; MCGRATH, CHRISTINE JENNIFER (contact);","RUSSO, DENISE","04/24/2019","03/31/2024","Africa; Bacteria; bacterial community; Bifidobacterium; bone; Breast Feeding; Cattle; Child; Childhood; Clinical Research; cohort; Cross-Sectional Studies; Data; Development; Diarrhea; dysbiosis; Enrollment; Enteral; epidemiology study; experience; feeding; follow-up; Functional disorder; global health; Growth; gut bacteria; gut microbiome; gut microbiota; Health; High Prevalence; high risk; HIV; HIV Infections; HIV-exposed uninfected infant; Human Milk; Immune; immune function; Immune system; improved; Incidence; Infant; Infant Development; infant gut microbiome; Infection; innovation; Intervention; Kenya; Lactation; lacto-N-neotetraose; lean body mass; Longitudinal Studies; Malnutrition; Mediating; microbial; microbiome; microbiota; Molecular Epidemiology; Morbidity - disease rate; mortality; Mother-to-child HIV transmission; Mus; Oligosaccharides; Outcome; Pathway interactions; Pneumonia; Population; Postpartum Period; prebiotics; Predisposition; Prevalence; prevent; Prevention; Probiotics; programs; prospective; Prospective cohort study; Prospective Studies; Research; Risk; Role; Seeds; success; therapy design; Time; Variant; Woman; ","Effects of Human Milk Oligosaccharides and Gut Microbiome on Growth and Morbidity in HIV-Exposed Uninfected Infants","096999","HCCS","HIV Comorbidities and Clinical Studies Study Section ","","A1","01","549882","217431","767313",""
"9781898","I01","VA","2","N","04/23/2019","04/01/2019","03/31/2020","999","I01BX002829","","RFA-BX-18-001","2I01BX002829-05","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","CHARLESTON","UNITED STATES","","01","039807318","US","481111","RALPH H JOHNSON VA MEDICAL CENTER","SC","294015703","Multiple sclerosis (MS) is a disabling neurological disease affecting individuals in their most productive years and is prevalent among US Veterans. The proposed study is to investigate the potential role of asymmetric dimethylarginine (ADMA), a naturally occurring L-arginine metabolite, in the pathogenesis of MS and to evaluate ADMA as a potential target for MS therapy. This proposal is based on the well-established role of ADMA in dysfunction of nitric oxide synthesis and its metabolism. Secondly, it is supported by our original contributions describing the role of nitric oxide metabolites in autoimmune response imbalance and blood-brain barrier dysfunction in the animal model of MS. We expect that the proposed study will delineate ADMA mediated disease mechanisms of MS and its clinical relevance as a novel prognostic disease marker and potential therapeutics for MS.","1878276; ","SINGH, INDERJIT ;","","04/01/2015","03/31/2023","Affect; Amino Acids; Animal Model; Animals; Anti-inflammatory; Arginine; attenuation; Autoimmune Diseases; Autoimmune Responses; autoreactivity; base; Biological; Blood; Blood - brain barrier anatomy; Blood Vessels; brain endothelial cell; Catabolism; Central Nervous System Diseases; Clinical; Clinical Pathology; clinically relevant; Development; dimethylargininase; Disease; Disease Marker; Disease Progression; Drug Targeting; Endothelial Cells; Experimental Autoimmune Encephalomyelitis; FDA approved; Folic Acid; Functional disorder; Goals; Health; Homeostasis; Homocysteine; Immune; Immune response; Immune system; Immune System Diseases; Immune Targeting; Immunologics; immunoregulation; Immunosuppression; Immunotherapy; Impairment; improved; Individual; Infiltration; Inflammatory; inhibitor/antagonist; insight; interest; Laboratories; Lead; Lymphocyte; Maintenance; Mediating; Metabolism; Mission; Modeling; mouse model; Multiple Sclerosis; multiple sclerosis patient; Mus; Myelin; N,N-dimethylarginine; nervous system disorder; Neurologic; neurological pathology; neuroprotection; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthetase Inhibitor; novel; novel therapeutics; Pathogenesis; Pathologic; Pathology; Peripheral; Peroxonitrite; Pertussis Toxin; Pharmaceutical Preparations; Physiological; Play; Process; Production; prognostic; Regulation; Regulatory T-Lymphocyte; Reporting; Role; S-Nitrosoglutathione; Safety; Severity of illness; Signal Transduction; Sulfhydryl Compounds; Superoxides; System; T-Lymphocyte; targeted treatment; Testing; Therapeutic; therapeutic target; Time; Vascular Diseases; Veterans; Vitamin B 12; ","Immunomodulation and Neuroprotection in Multiple Sclerosis","002829","ZRD1","Special Emphasis Panel ","","","05","","","",""
"9782672","IK2","VA","1","N","04/22/2019","04/01/2019","03/31/2020","999","IK2CX001884","","RFA-CX-18-008","1IK2CX001884-01A1","","OTHERS","2019","Veterans Affairs","","LOS ANGELES","UNITED STATES","","33","066689118","US","481012","VA GREATER LOS ANGELS HEALTHCARE SYSTEM","CA","900731003","The goal of the proposed research is to learn how to optimize psychotherapy for older Veterans with chronic pain. Chronic pain affects 50% of all Veterans and up to 80% of older Veterans and is notoriously hard to treat. VA recommends psychotherapy as an important treatment for chronic pain, but standard psychotherapy, including Cognitive Behavior Therapy (CBT), produces only modest benefits. In published data and pilot work, a new psychotherapy approach, Emotional Awareness and Expression Therapy (EAET), has shown medium to large benefits for some Veterans. The proposed research evaluates whether EAET is more effective overall than CBT for older Veterans with chronic pain, examines whether psychiatric symptoms like depression and anxiety can predict which Veterans are most likely to respond, and explores how each treatment works. If successful, this research could lead to more Veterans with chronic pain responding to psychotherapy and better targeting of each psychotherapy to Veterans most likely to benefit.","15053886; ","YARNS, BRANDON C;","","04/01/2019","03/31/2024","Affect; Aftercare; Age; Anxiety; anxiety symptoms; Awareness; base; Behavioral; Brain region; career development; Centers for Disease Control and Prevention (U.S.); chronic musculoskeletal pain; chronic pain; chronic pain patient; Client satisfaction; Clinical Trials; Cognitive; cognitive benefits; cognitive enhancement; Cognitive Therapy; Comorbidity; Conflict (Psychology); coping; Coping Skills; Data; depressive symptoms; Development; Educational process of instructing; emotion regulation; Emotional; emotional distress; Emotions; Enrollment; Environment; Epidemic; Fatigue; Female; follow-up; Functional disorder; Goals; Healthcare; Healthcare Systems; improved; Infrastructure; innovation; Intervention; Lead; Learning; Life Stress; Light; Literature; Los Angeles; male; Measures; Mediating; Mediation; Mediator of activation protein; Medical; Medical center; Mental Depression; Mentors; Moods; novel; Opioid Analgesics; opioid epidemic; Pain; pain catastrophizing; Pain interference; Pain management; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Post-Traumatic Stress Disorders; primary outcome; Proxy; psychiatric symptom; psychologic; psychosocial; Psychotherapy; Publishing; Randomized Clinical Trials; Recommendation; Research; response; Risk; secondary outcome; Severities; showing emotion; skills; Sleep; Sleep disturbances; standard care; Symptoms; Testing; Trauma; Veterans; Work; ","Optimizing Psychotherapy for Older Veterans with Chronic Pain","001884","ZRD1","Special Emphasis Panel ","","A1","01","","","",""
"9805827","R01","DK","7","N","04/24/2019","12/01/2018","11/30/2019","847","R01DK114224","","PA-18-590","7R01DK114224-02","NIDDK:349359\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","COLLEGE STATION","UNITED STATES","","17","847205713","US","8266920","TEXAS A&M AGRILIFE RESEARCH","TX","778430001","Urinary tract infection (UTI) is an extremely common infectious disease affecting ~11 million people annually in the United States. By elucidating the protective role of copper during UTI and bolstering copper response in the host to resolve UTI, the proposed research is expected to engender a significant public health benefit against UTI and is perfectly aligned with the NIH's mission of `turning discovery into health'.","11972013; ","SUBASHCHANDRABOSE, SARGURUNATHAN ;","MULLINS, CHRISTOPHER V","12/01/2018","11/30/2022","Affect; alcohol abuse prevention; Animal Model; Antibiotic Resistance; Antibiotics; Bacteremia; Bacterial Infections; base; Biological; Biological Availability; Bladder; Catheters; Ceruloplasmin; Child; Clinical; Communicable Diseases; Copper; Data; Diabetes Mellitus; Diet; Direct Costs; Disease; Disulfiram; efflux pump; Elderly; Escherichia coli Infections; Etiology; FDA approved; Goals; Health; Health Benefit; Host Defense; Human; Immune response; in vivo; Individual; innovation; Intervention; Iron; kidney infection; Killings; macrophage; Mediating; Menkes Kinky Hair Syndrome; Mission; Modeling; Molecular; Mus; neutrophil; nonhuman primate; novel; novel strategies; Outcome Study; Pain; pathogen; Patients; Phagocytes; Pharmaceutical Preparations; Pharmacology; Physicians; Prevalence; Primates; protective effect; Proteins; Public Health; Publishing; Recurrence; Reporting; Research; Resolution; response; Role; Sepsis; Signal Transduction; Site; targeted treatment; Testing; Therapeutic; therapeutic development; Toxic effect; United States; United States National Institutes of Health; urinary; Urinary Calculi; Urinary tract; Urinary tract infection; Urine; Uropathogenic E. coli; Urothelium; Virulence; Visit; Woman; Work; ","Copper is a Host Effector in Protection Against Urinary Tract Infection","114224","ZRG1","Special Emphasis Panel ","","","02","237928","111431","349359",""
"9828389","R01","HL","7","N","04/21/2019","04/22/2019","05/31/2019","837","R01HL075360","","PA-18-590","7R01HL075360-16","NHLBI:17690\","Non-SBIR/STTR RPGs","2018","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","PUBLIC HEALTH RELEVANCE:  Patients who have had a heart attack are at high risk to develop congestive heart failure, and the 5 year mortality rate for heart failure is 50%. The macrophage is a major cell that coordinates wound healing in the heart after a heart attack, and modifying the macrophage response may improve outcomes. The main objective of this grant is to construct a simulation of the macrophage response to a heart attack, which may help us to develop therapies that prevent the development of heart failure.","2085149; ","LINDSEY, MERRY L;","ADHIKARI, BISHOW B","11/22/2018","05/31/2019","","Systems Biology of Macrophage Polarizaiton Following Myocardial Infarction","075360","ZRG1","Special Emphasis Panel ","","","16","11600","6090","17690",""
"9830435","R01","HL","7","N","04/20/2019","04/22/2019","03/31/2020","837","R01HL138493","","PA-18-590","7R01HL138493-02","NHLBI:398774\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PROVIDENCE","UNITED STATES","","01","075710996","US","6959701","RHODE ISLAND HOSPITAL","RI","029034923","Successful completion of this project will enhance our understanding of the molecular mechanisms controlling cardiac regeneration, and potentially identify novel targets to exploit for stimulating cardiac proliferation following myocardial infarction.","1896574; ","RADICE, GLENN LAWRENCE;","ADHIKARI, BISHOW B","12/01/2018","03/31/2022","Actins; Actomyosin; Adhesions; Adult; Agonist; alpha catenin; Animal Model; Architecture; Atomic Force Microscopy; beta catenin; Binding; Biomechanics; Birth; blood pump; Cadherin Domain; Cadherins; Cancer Biology; Cardiac; Cardiac development; Cardiac Myocytes; cardiac regeneration; cardiogenesis; Cell physiology; Cell Proliferation; Cell-Cell Adhesion; Cells; Complex; Couples; Cytoskeleton; Deposition; Development; Down-Regulation; Elasticity; extracellular; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Focal Adhesions; genetic manipulation; Heart; heart cell; Heart failure; heart function; Human; improved; improved functioning; in vivo; inhibitor/antagonist; injured; Injury; insight; Integrin alpha5; Integrins; Intercalated disc; Knock-out; Laboratories; Lead; Life; loss of function; Mammalian Cell; mechanical force; mechanical load; mechanical properties; Mechanics; mechanotransduction; Mediating; Molecular; mouse model; Muscle; Muscle Cells; Myocardial Infarction; N-Cadherin; Natural regeneration; Neonatal; novel; novel therapeutic intervention; Nuclear; Nuclear Translocation; Pathologic; Pathway interactions; Patients; Phosphotransferases; Physiological; Play; polyacrylamide hydrogels; postnatal; preclinical study; receptor; regenerative; repaired; response; rho; Role; Signal Transduction; System; Testing; Tissues; Transcription Coactivator; tumor; Work; ","Mechanotransduction in Heart Development and Regeneration","138493","CDD","Cardiovascular Differentiation and Development Study Section ","","","02","250000","148774","398774",""
"9843587","K99","HD","7","N","04/26/2019","01/01/2019","08/31/2019","865","K99HD096120","SCHOOLS OF ARTS AND SCIENCES","PA-18-590","7K99HD096120-02","NICHD:74520\","OTHER RESEARCH-RELATED","2018","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","KENT","UNITED STATES","BIOLOGY","13","041071101","US","1523302","KENT STATE UNIVERSITY","OH","442420001","Project Narrative Polycystic ovarian syndrome (PCOS) is the leading cause of infertility, affecting 6-10% of women of reproductive age worldwide. This study will define the critical central neuronal circuits controlling fertility and determine whether perturbations within these circuits drive the pathophysiology of PCOS. Importantly, identifying and understanding central defects in PCOS may lead to therapeutic approaches and preventative strategies for treating the syndrome in patients.","14962293; ","MOORE, ALEISHA ;","EISENBERG, ESTHER","01/01/2019","08/31/2020","","The role of Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons in the pathogenesis of polycystic ovarian syndrome","096120","CHHD","Reproduction, Andrology, and Gynecology Subcommittee ","","","02","69000","5520","74520",""
"9864217","F32","CA","5","N","04/18/2019","04/25/2019","04/24/2020","398","F32CA224677","SCHOOLS OF PUBLIC HEALTH","PA-16-307","5F32CA224677-02","NCI:64351\","TRAINING, INDIVIDUAL","2019","NATIONAL CANCER INSTITUTE","","HADLEY","UNITED STATES","BIOSTATISTICS & OTHER MATH SCI","02","153926712","US","850904","UNIVERSITY OF MASSACHUSETTS AMHERST","MA","010359450","PROJECT NARRATIVE Waist circumference may be a better predictor of breast cancer risk and survival than BMI, or measuring both waist circumference and BMI may provide the best information. Additionally assessing specific tumor markers may help confirm whether central obesity causes breast cancer and, if so, how. The results of the study may suggest a new way to identify women who are at high risk of breast cancer (who may benefit from increased screening or risk reducing options) or an additional strategy to prevent breast cancer.","14078801; ","HOUGHTON, SERENA CATHERINE;","","04/25/2018","04/24/2021","Address; adipokines; Androgen Receptor; Androgens; Biological; Body mass index; breast cancer diagnosis; Breast Cancer Prevention; Breast Cancer Risk Factor; breast cancer survival; Breast Carcinogenesis; burden of illness; Cancer Prognosis; cancer survival; carcinogenesis; Central obesity; Characteristics; Chemoprevention; cytokine; Data; Development; Diagnosis; epidemiology study; Estrogen Receptor Status; Estrogen Receptors; Estrogens; Etiology; follow-up; high risk; High Risk Woman; Hip region structure; Hormonal; Hormones; improved; Inflammatory; insight; Insulin; Insulin Receptor; insulin signaling; Lead; Link; malignant breast neoplasm; Mammary Neoplasms; Measurement; Measures; Medical Records; Menopausal Status; Metabolic; modifiable risk; molecular marker; molecular subtypes; Morbidity - disease rate; mortality; Mutation; Nurses' Health Study; Obesity; Pathway interactions; Pharmaceutical Preparations; Physical activity; PIK3CA gene; Postmenopause; predictive modeling; Premenopause; Progesterone; Prospective cohort; PTEN gene; Questionnaires; receptor expression; Reporting; Research; Resources; Risk; Risk Factors; Risk Reduction; Role; Sample Size; screening; Subgroup; Time; tumor; Tumor Markers; Tumor Tissue; waist circumference; Waist-Hip Ratio; Woman; Work; ","Central Obesity in Relation to Breast Cancer Risk and Survival","224677","ZRG1","Special Emphasis Panel ","","","02","64351","","64351",""
"9869334","K00","CA","4","N","04/24/2019","04/23/2019","03/31/2020","398","K00CA212225","SCHOOLS OF MEDICINE","RFA-CA-16-005","4K00CA212225-03","NCI:67812\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","DURHAM","UNITED STATES","PHARMACOLOGY","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","PROJECT NARRATIVE Prostate Cancer (PCa) exists as a leading cause of male cancer-related death in the United States, and studies from our lab have shown that upregulation of the deubiquitinase USP22 is capable of driving PCa progression via the AR/MYC axes. Importantly, USP22, a component of the SAGA transcriptional activation complex and a member of an established ?death from cancer? gene signature, is overexpressed in late-stage PCa human clinical samples, acting as an indicator of poor outcome in PCa patients. Here I intend to further characterize the biochemical means with which USP22 drives PCa progression, and demonstrate the effects of tumor-associated USP22 on therapeutic bypass.","12502244; ","MCCANN, JENNIFER JONES;","JAKOWLEW, SONIA B","04/23/2019","03/31/2023","Address; Affect; androgen deprivation therapy; Androgen Receptor; anticancer research; Automobile Driving; Binding; Biochemical; Biological Models; Biology; Bypass; c-myc Genes; Cancer Etiology; cancer initiation; Cancer Patient; cancer type; Cessation of life; Chromatin; Clinical; Complex; Data; Development; Disease; DNA Damage; Event; experience; Fellowship; Genes; genetic regulatory protein; genetic signature; Genetic Transcription; genome-wide; Goals; Human; human model; in vivo; interest; male; Malignant neoplasm of prostate; Malignant Neoplasms; member; men; Mentors; Modeling; mouse model; Nature; novel; Oncogenes; Oncogenic; Organ; Outcome; outcome forecast; overexpression; Pathway interactions; Phase; Phenotype; Physiological; pre-doctoral; premature; programs; Prostate; Prostate Adenocarcinoma; prostate cancer cell; prostate cancer progression; Protein Deregulation; Receptor Signaling; Research; Research Project Grants; Resistance; response; Role; SAGA; Sampling; Signal Transduction; Site-Directed Mutagenesis; skills; standard of care; symposium; Therapeutic; therapeutic target; TP53 gene; Transcription Alteration; Transcription Regulatory Protein; Transcriptional Activation; transcriptome; translational cancer research; tumor; tumor progression; Tumor Suppressor Proteins; United States; Up-Regulation; Work; ","The Role of USP22 in Prostate Cancer Development and Progression","212225","ZCA1","Special Emphasis Panel ","","","03","62789","5023","67812",""
"9872634","R01","CA","7","N","04/24/2019","04/24/2019","08/31/2019","394","R01CA218739","BIOMED ENGR/COL ENGR/ENGR STA","PA-18-590","7R01CA218739-02","NCI:324006\","Non-SBIR/STTR RPGs","2018","NATIONAL CANCER INSTITUTE","","NORMAN","UNITED STATES","ENGINEERING (ALL TYPES)","04","848348348","US","1524002","UNIVERSITY OF OKLAHOMA NORMAN","OK","730199705","Early detection of both new and recurrent oral cancer holds great promise for improving both the survival rate and the quality of live of these patients. The proposed work is to develop a clinical tool capable of quantifying noninvasively different biomarkers associated to oral epithelial cancer progression and detecting early stage oral cancer and dysplasia. Such tool will revolutionize oral epithelial cancer management by allowing not only early screening and diagnosis, but also treatment guidance and monitoring for disease recurrence.","8800452; ","JO, JAVIER ANTONIO;","TATA, DARAYASH B","02/02/2018","08/31/2023","","Endogenous fluorescence lifetime endoscopy for early detection of oral cancer and dysplasia","218739","BMIT","Biomedical Imaging Technology Study Section ","","","02","255963","68043","324006",""
"9902698","R01","MD","3","N","04/23/2019","04/01/2019","01/31/2020","307","R01MD010618","SCHOOLS OF PUBLIC HEALTH","RFA-MD-15-010","3R01MD010618-04S1","NIMHD:101090\","Non-SBIR/STTR RPGs","2019","National Institute on Minority Health and Health Disparities","","HADLEY","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","02","153926712","US","850904","UNIVERSITY OF MASSACHUSETTS AMHERST","MA","010359450","PUBLIC HEALTH RELEVANCE: African-American men continue to bear a disproportionate share of the burden of health disparities, in general, and chronic diseases such as heart disease, cancer, stroke and diabetes, in particular. It is vitally important to identify effective strategies to ameliorate these health inequities. The research plan presented here will identify factors that have the greatest influence on stress and health behaviors in low-income African-American men between the ages 45-65, and determine the effectiveness of an innovative, community-driven program to improve the health and quality of life of these men.","1954868 (contact); 10011962; ","BUCHANAN, DAVID R. (contact); GRAHAM, LOUIS F;","TABOR, DERRICK C","06/10/2016","01/31/2021","Address; Aerobic Exercise; Affect; African American; Age; Age-Years; Area; arm; Awareness; base; Blood Pressure; Body fat; Chronic Disease; cohort; Collaborations; Collection; Color; Communication; Communities; community based participatory research; comparison group; Data; Data Analyses; Data Collection; design; Development; Diabetes Mellitus; Diet; Diet Habits; digital; Discrimination; disorder control; disorder prevention; Economic Conditions; Educational workshop; effective intervention; Effectiveness; Enzyme-Linked Immunosorbent Assay; Ethnography; evidence base; Exercise; experience; fitness; follow-up; Gender; Gender Role; Hair; Health; Health behavior; health disparity; Health Sciences; Heart Diseases; Hormones; Hydrocortisone; Hypertension; improved; Individual; innovation; instrument; interest; Intervention; Interview; Investigation; Logic; Low income; male health; Malignant Neoplasms; Massachusetts; Measures; Mediating; men; Mental Depression; Minority; Mission; Modeling; Morbidity - disease rate; mortality; nutrition; Obesity; Outcome; Participant; Pathway interactions; Patient Self-Report; Personal Satisfaction; Phase; Physical activity; Physiological; Population; Prevention program; Preventive Intervention; Privatization; Program Effectiveness; programs; Psyche structure; Public Health; public health relevance; Public Health Schools; public-private partnership; Quality of life; Questionnaires; Randomized Controlled Trials; recruit; Research; Research Design; Research Methodology; Research Personnel; resilience; Risk; Running; Sampling; secondary outcome; Series; social; social health determinants; stem; Stress; Stroke; Substance abuse problem; Surveys; Testing; Theoretical model; Universities; Ursidae Family; Violence; Waiting Lists; Weight; ","MOCHA Moving Forward:  a CBPR investigation of chronic disease prevention in older, low-income African-American men","010618","ZMD1","Special Emphasis Panel ","","S1","04","63379","37711","101090",""
"9912919","R01","HD","7","N","04/26/2019","09/01/2018","08/31/2019","865","R01HD081199","SCHOOLS OF MEDICINE","PA-13-216","7R01HD081199-05","NICHD:646945\","Non-SBIR/STTR RPGs","2018","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","LOS ANGELES","UNITED STATES","NEUROSCIENCES","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","PUBLIC HEALTH RELEVANCE: 'Transitioning to Adulthood: A prospective longitudinal study' This prospective study will examine the behavioral and social mechanisms that account for variability of the adult ASD phenotype. Factors that contribute to positive and negative outcomes in adults with ASD, including various dimensions of behavior and well-being, the sibling relationship, family functioning, service utilization, and access to transition planning (eg. identification of goals and related, key supports), will be identified. The study results will infom the clinical care of both adults and children with ASD.","1876287; ","LORD, CATHERINE ;","KAU, ALICE S","09/01/2015","08/31/2020","","Transitioning to Adulthood: A Prospective Longitudinal Study","081199","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","","05","419728","227217","646945",""
"9916056","UG1","DA","3","N","04/22/2019","02/01/2019","05/31/2019","279","UG1DA015831","","RFA-DA-15-008","3UG1DA015831-17S5","NIDA:83360\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","BELMONT","UNITED STATES","","05","046514535","US","1876801","MCLEAN HOSPITAL","MA","024781064","PUBLIC HEALTH RELEVANCE:  The National Drug Abuse Treatment Clinical Trials Network (CTN) conducts clinically relevant drug abuse research in real-world settings, with an increasing emphasis on conducting studies in general medical settings. The New England Consortium Node of the CTN is poised to foster the development of effective, scalable, and sustainable interventions for individuals with a variety of substance use problems, so that they can be offered effective treatment in whatever healthcare setting they enter, thus improving overall public health.","1883776; 1869395 (contact); ","CARROLL, KATHLEEN M.; WEISS, ROGER D. (contact);","DOBBINS, RONALD","09/30/2002","05/31/2020","Accident and Emergency department; addiction; Address; Adolescent; Adult; Alcohol or Other Drugs use; Alcohols; Area; base; Boston; Buprenorphine; Caring; Child Care; chronic pain patient; cigarette smoke; Clinical; clinical infrastructure; clinical practice; Clinical Research; clinical research site; Clinical Treatment; Clinical Trials Network; clinically relevant; Cognitive Therapy; Communities; Computers; Connecticut; cost efficient; Data; Development; Diabetes Mellitus; Discipline of obstetrics; Doctor of Medicine; Doctor of Philosophy; Drug abuse; Drug usage; effective therapy; Effectiveness; efficacy research; efficacy trial; Electronic Health Record; Emergency Care; Face; financial incentive; Fostering; Funding; Goals; health care delivery; Health care facility; health care settings; health information technology; Health system; Healthcare; Healthcare Systems; high risk men; HIV; Hospital Departments; Hospitalization; Hospitals; improved; improved outcome; Individual; innovation; innovative technologies; Intervention; Intervention Studies; Leadership; Medical; Medical center; medical specialties; Medicine; methamphetamine use; multidisciplinary; National Institute of Drug Abuse; New England; new technology; novel strategies; Operative Surgical Procedures; Opiate Addiction; opioid misuse; Patient Care; patient registry; Patients; Pediatric Research; peer; Peer Review; Play; Population; pragmatic trial; Pregnancy; Pregnant Women; prenatal cigarette smoking; Primary Health Care; Productivity; Psychiatric therapeutic procedure; Public Health; public health relevance; Publications; recruit; Research; Research Infrastructure; Research Personnel; Research Project Grants; Risk; rural area; screening and brief intervention; Seminal; Series; Site; Smoking; smoking cessation; standard of care; Substance Use Disorder; System; treatment program; trend; United States; Universities; Veterans; virtual; Work; ","The National Drug Abuse Treatment Clinical Trials Network","015831","ZDA1","Special Emphasis Panel ","","S5","17","50829","32531","83360",""
"9920425","R01","DC","3","N","04/24/2019","07/01/2018","06/30/2019","173","R01DC005991","SCHOOLS OF DENTISTRY/ORAL HYGN","PA-16-160","3R01DC005991-11A1S2","NIDCD:45000\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS","","SAN FRANCISCO","UNITED STATES","ANATOMY/CELL BIOLOGY","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","Project Narrative How sleep benefits the nervous system is unknown and specifically how it affects memory consolidated is still a mystery. Our lab is the first, to our knowledge, to have discovered that C. elegans require sleep after a spaced learning task in order to consolidate memory. Thus, we propose to leverage this anatomically simple, transparent organism to understand how this enigmatic yet beneficial process of sleep affects memory. The rules employed by a simple circuit are likely to be followed by cells within the circuit modules that link together to form the much more complicated neural network of a human brain.","1874656; ","L 'ETOILE, NOELLE D;","SULLIVAN, SUSAN L","12/05/2004","06/30/2023","Address; Affect; Aging; Alzheimer's Disease; Anatomy; Animals; Architecture; Arousal; base; Behavior; Behavioral; behavioral plasticity; biochemical tools; Biological Process; Brain; Butanones; Caenorhabditis elegans; Cell physiology; Cells; Cellular biology; Chordata; Chromatin; classical conditioning; Cnidaria; Coupled; critical period; Data; deprivation; design; Disease; Dopamine; EGF gene; Exhibits; feeding; fitness; fly; gamma-Aminobutyric Acid; Genes; Human; Image; improved; Individual; Interneurons; Learning; Light; Link; Locomotion; Mechanics; Memory; memory acquisition; memory consolidation; memory encoding; Mental Depression; Modeling; Molecular; Mood Disorders; Morphology; Movement; Mus; Nematoda; Nerve Degeneration; nervous system disorder; Nervous system structure; neural network; neuronal patterning; Neurons; neuroprotection; Odors; Olfactory Pathways; olfactory sensory neurons; Optics; optogenetics; Organism; Output; Pathway interactions; Performance; physical state; Physiological; postsynaptic neurons; Posture; Process; Property; Proteins; Reporting; Resolution; response; Rest; Role; Sleep; sleep behavior; Sleep Disorders; Sleep disturbances; sleep regulation; Synapses; System; Testing; Time; tool; Training; ","Olfactory memory acquisition consolidation and recall","005991","ZRG1","Special Emphasis Panel ","","A1S2","11","0","45000","45000",""
"9921209","I01","VA","5","N","04/25/2019","04/01/2019","09/30/2019","999","I01HX001128","","RFA-HX-12-018","5I01HX001128-05","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","BALTIMORE","UNITED STATES","","07","796532609","US","481039","BALTIMORE VA MEDICAL CENTER","MD","212011524","Narrative: The VHA is committed to providing long-term care in a home-like environment. This has to be  balanced with patient safety and protecting residents from MRSA infections. Infections in CLCs are a primary  cause for transfer to acute-care and have led to outbreaks in acute-care facilities. The most common cause of  infections is MRSA. In acute-care, patients with MRSA are isolated in their room and healthcare workers are  required to use gowns and gloves for entry. Isolation is highly debated in long-term care. These measures  lessen the home-like environment and, small studies suggest, may lead to depression, delirium and adverse  events. The goals of this project are to establish a scientific foundation for MRSA infection prevention policy in  long-term care settings both quantitatively and qualitatively balancing infection prevention, patient safety and  the ideals of patient-centered care.","9252431; ","MORGAN, DANIEL J;","","04/01/2015","09/30/2019","Acute; Adherence; Admission activity; Adopted; Adverse effects; Adverse event; adverse outcome; Affect; Anxiety; barrier to care; base; Behavior; Belief; Boston; Caring; Centers for Disease Control and Prevention (U.S.); Cities; community living; Community Surveys; comparative; comparative effectiveness; Data; Data Quality; Data Set; Databases; Decubitus ulcer; Delirium; design; Disease Outbreaks; Education; Effectiveness; Elements; Environment; Equilibrium; Evaluation; falls; Foundations; Frequencies; Future; Geography; Goals; Hand; Health care facility; Health Personnel; Healthcare Systems; healthcare-associated infections; Home environment; Hygiene; improved; Infection; Infection Control; Infection prevention; Inpatients; Interview; Iowa; Knowledge; Lead; Long-Term Care; Maryland; Measures; Medical; Mental Depression; Mental Health; methicillin resistant Staphylococcus aureus; Methods; Modeling; Observational Study; Outcome; Patient Care; patient safety; Patient-Centered Care; Patients; Pattern; Perception; Physicians; Policies; Population; Prevention; Prevention education; Prevention Guidelines; Prevention Protocols; Prevention strategy; Privatization; Procedures; Process Measure; Protocols documentation; Publications; recruit; Rehabilitation Nursing; Research; residence; Residential Treatment; Role; Safety; Sampling; Science; Site; Standard precautions; Structure; Surveys; System; Techniques; Testing; Variant; Veterans; Visit; ","Comparative safety and effectiveness of isolation in VHA community living centers","001128","HCR1","HCR 1 - CREATE PTSD ","","","05","","","",""
"9572661","P30","EY","2","N","04/25/2019","04/01/2019","03/31/2020","","P30EY008098","","PAR-17-322","2P30EY008098-31","NEI:259533\","RESEARCH CENTERS","2019","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","","11426441; ","SIGAL, IAN A;","","","","base; Biological Assay; Caring; Core Grant; Data; data acquisition; Data Analyses; Data Collection; data integrity; Data Storage and Retrieval; Development; Equipment; Ethical Analysis; Ethics; experience; Experimental Designs; Faculty; Fluorescence; Funding; Goals; Image; Image Analysis; imaging modality; Knowledge; Laboratories; Methodology; Methods; Microscopy; Optical Coherence Tomography; Phase; Protocols documentation; Research Personnel; Research Project Grants; success; Technical Expertise; theories; Training; Vision; Vision research; ","Image Acquisition and Analysis Core","008098","ZEY1","Special Emphasis Panel ","5949","","31","165836","93697","","259533"
"9627746","U10","CA","2","N","04/23/2019","04/23/2019","02/29/2020","395","U10CA180899","","RFA-CA-17-057","2U10CA180899-06","NCI:7704817\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","OAKLAND","UNITED STATES","","13","128663390","US","1618201","PUBLIC HEALTH INSTITUTE","CA","946074046","PROJECT NARRATIVE The Children?s Oncology Group (COG) is the world?s largest organization devoted exclusively to childhood and adolescent cancer research. Over 220 leading children?s hospitals, universities, and cancer centers across US, Canada and other countries participate in COG research, which is focused on developing better treatments that can improve the cure rate and outcome for all children with cancer.","1857551; ","ALONZO, TODD A;","MOONEY, MARGARET M","04/15/2014","02/28/2025","1 year old; Acute; Acute Myelocytic Leukemia; Adolescent; Advanced Development; anticancer research; Australia; base; Biology; Brain Stem Glioma; Canada; Cancer Center; Cancer Patient; Cancer Survivor; cancer therapy; Caring; Cause of Death; chemotherapy; Child; Child Support; Childhood; childhood cancer survivor; Childhood Cancer Treatment; Childhood Leukemia; Clinical; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Design; Collaborations; Collection; Communities; Companions; Complication; Country; Data; data management; density; design; Diagnosis; Disease; Ensure; experience; Family; Foundations; Functional disorder; functional outcomes; Generations; Genomics; Goals; health related quality of life; high risk; Hormonal; Immunotherapy; improved; improved outcome; Industry; Infrastructure; innovation; Institution; Interdisciplinary Study; Knowledge; Laboratories; Late Effects; Malignant Childhood Neoplasm; Malignant Neoplasms; member; Methods; Mission; Molecular; Morbidity - disease rate; mortality; multidisciplinary; National Cancer Institute; National Clinical Trials Network; Neuroblastoma; New Zealand; novel; novel therapeutic intervention; Organ; organizational structure; Outcome; outcome forecast; Patients; Pediatric Hospitals; Pediatric Oncology Group; Pharmaceutical Preparations; Population Heterogeneity; Population Research; programs; Quality of life; Rare Diseases; Reporting; reproductive; Research; Research Personnel; Science; Second Primary Cancers; sharing data; small molecule; statistics; Survival Rate; Survivors; survivorship; Time; Tissues; translational clinical trial; Translational Research; translational scientist; translational study; trial design; United States; Universities; Work; ","Children's Oncology Group Statistics and Data Center","180899","ZCA1","Special Emphasis Panel ","","","06","7436509","904293","7704817",""
"9662792","R01","CA","5","N","04/23/2019","04/01/2019","03/31/2020","393","R01CA206010","SCHOOLS OF MEDICINE","RFA-CA-15-008","5R01CA206010-04","NCI:358550\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","ANN ARBOR","UNITED STATES","INTERNAL MEDICINE/MEDICINE","12","073133571","US","1506502","UNIVERSITY OF MICHIGAN AT ANN ARBOR","MI","481091276","PUBLIC HEALTH RELEVANCE: Colorectal cancers present more advanced and have higher mortality among African Americans. The prevalence of two biomarkers based on intracellular DNA repair and associated inflammation in African American cancers favor lower survival. We aim to determine the relationship between the pro-inflammatory cytokine IL-6 and one of the biomarkers that portend poor prognosis in the cancers from African Americans. The IL-6 pathway and inflammation is targetable that may ultimately have an impact on improving survival for this racial group.","1877321; ","CARETHERS, JOHN M;","OKANO, PAUL","04/01/2016","03/31/2021","Address; African American; Anti-Inflammatory Agents; Aspirin; base; Biological; Biological Markers; Caucasians; Cell Nucleus; Cells; colon cancer patients; Colorectal Cancer; Copy Number Polymorphism; cytokine; Data; Death Rate; Defect; Diet; DNA; DNA Repair; Ethnic Origin; Frameshift Mutation; Frequencies; Genetic; genetic signature; Granzyme; Human; Immune; Immune response; Immunologics; immunoregulation; improved; improved outcome; Incidence; Inflammation; Inflammatory; inhibitor/antagonist; Interleukin-6; intraepithelial; Life Style; Link; Malignant Neoplasms; Microsatellite Instability; Microsatellite Repeats; Mismatch Repair; mismatch repair protein 1; mortality; MSH3 gene; Mutation; Neoplasm Metastasis; Non-Steroidal Anti-Inflammatory Agents; novel; Outcome; outcome forecast; Pathway interactions; Patient-Focused Outcomes; Patients; Prevalence; Prognostic Marker; public health relevance; Race; Signal Pathway; Signal Transduction; socioeconomics; survival outcome; Testing; Tetranucleotide Repeat; tumor; United States; ","(PQ3) Immune Modulation of DNA Mismatch Repair in Colorectal Cancer","206010","ZCA1","Special Emphasis Panel ","","","04","231323","127227","358550",""
"9662823","R01","GM","5","N","04/23/2019","04/01/2019","03/31/2020","859","R01GM078097","SCHOOLS OF MEDICINE","PA-13-302","5R01GM078097-12","NIGMS:375464\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BURLINGTON","UNITED STATES","PHYSIOLOGY","00","066811191","US","8738101","UNIVERSITY OF VERMONT & ST AGRIC COLLEGE","VT","054051704","PUBLIC HEALTH RELEVANCE: Molecular motors are ubiquitous in eukaryotic cells, and play crucial roles in organelle transport and membrane trafficking. Characterizing the function of class V myosins is critical to understanding mechanisms that regulate the internal organization of cells, and how disrupted motor functions lead to human diseases (e.g. Griscelli syndrome, microvillus inclusion disease). Mutations in kinesin and dynein cause a myriad number of neurodegenerative diseases. Understanding the interplay between these two motors at the molecular level, and how these interactions affect mRNA transport and localization, will contribute to informed design of new preventative or therapeutic interventions for these diseases.","1887374; ","TRYBUS, KATHLEEN M;","GINDHART, JOSEPH G","06/01/2007","03/31/2020","Actins; Adaptor Signaling Protein; Address; Affect; base; Behavior; Binding; Biological; cell motility; Cell physiology; Cells; cellular microvillus; Complex; Coupled; Cytomegalovirus Infections; Cytoplasmic Granules; Dependence; design; Disease; DNA; Drosophila genus; dynactin; Dynein ATPase; Endoplasmic Reticulum; Eukaryota; Eukaryotic Cell; expectation; Fluorescence Microscopy; Frequencies; Functional disorder; Griscelli Syndrome; human disease; In Vitro; in vitro Assay; in vivo; insulin granule; Kinesin; knock-down; Lead; Length; Mammals; melanocyte; Melanosomes; Membrane; messenger ribonucleoprotein; Messenger RNA; Microtubules; MLPH gene; Molecular; Molecular Motors; Morphology; Motion; Motor; Movement; Mutation; Myosin ATPase; Myosin Type V; Neurodegenerative Disorders; Organelles; Play; Preventive Intervention; Property; protein complex; Protein Isoforms; Proteins; public health relevance; reconstitution; Reporting; Role; Running; Secretory Vesicles; single molecule; Specific qualifier value; Specificity; Speed; Testing; Therapeutic Intervention; Tissues; trafficking; Transcript; Tropomyosin; Walking; Yeasts; ","Mutational Studies of Processive Myosin Motors","078097","MSFC","Macromolecular Structure and Function C Study Section ","","","12","240682","134782","375464",""
"9665143","U19","AI","1","N","04/22/2019","04/01/2019","03/31/2020","","U19AI142636","","PAR-15-330","1U19AI142636-01","NIAID:120005\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAN ANTONIO","UNITED STATES","","23","007936834","US","7660801","TEXAS BIOMEDICAL RESEARCH INSTITUTE","TX","782450549","","1872914; ","RUPRECHT, RUTH MARGRIT;","","05/01/2019","04/30/2024","Achievement; Acquired Immunodeficiency Syndrome; Address; Area; base; Biomedical Research; Biotechnology; Budgets; Businesses; capsule; Cold Chains; Collaborations; Communication; Country; Data; design; dosage; Europe; European; experimental study; Goals; HIV vaccine; HIV-1; ileum; Image; immunogenicity; Immunology; Individual; Infectious Agent; innovation; Institutes; Institution; Intellectual Property; Lead; Louisiana; Macaca mulatta; manufacturing process; Manuscripts; material transfer agreement; Medicine; meetings; Modeling; Monitor; Mucous Membrane; National Institute of Allergy and Infectious Disease; Needles; nonhuman primate; novel vaccines; Oral; payment; Positron-Emission Tomography; prevent; Primates; programs; Protocols documentation; Publications; Radionuclide Imaging; Reagent; Reporting; Research; Research Institute; Research Personnel; Resources; Sampling; Science; Scientist; Ships; simian human immunodeficiency virus; Site Visit; skills; Solid; Switzerland; Technology; Texas; Time; Training; Travel; United States National Institutes of Health; Universities; vaccine delivery; vaccine development; Vaccines; Viral Pathogenesis; Virginia; Virosomes; Visit; Washington; whole body imaging; ","Administration","142636","ZAI1","Special Emphasis Panel ","6241","","01","62666","57339","","120005"
"9665267","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:356742\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","2404525; ","CARRASQUILLO, OLVEEN ;","","","","African American; Area; Attenuated; Award; base; cancer health disparity; care systems; Catchment Area; Chronic; Clinical Data; Collaborations; Communities; community based participatory research; community organizations; design; Discipline; disorder prevention; Educational Activities; effective intervention; Ensure; Ethics; ethnic diversity; ethnic minority population; Event; experience; Failure; Florida; Fostering; Funding; Goals; Health; health disparity; health equity; Health Promotion; Health Sciences; improved; Incidence; Individual; Infrastructure; infrastructure development; Institutes; Institution; interest; Investments; Latino; Lead; member; mortality; novel; novel strategies; Outcome; Outreach Research; Patients; personalized approach; Persons; population health; precision medicine; Process; Productivity; programs; racial and ethnic; racial diversity; recruit; Research; Research Activity; research and development; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Science; Seeds; skills; Structure; Universities; uptake; user-friendly; Vulnerable Populations; willingness; ","Consortium Core","010722","ZMD1","Special Emphasis Panel ","8200","","04","335332","74613","","356742"
"9672434","P30","ES","5","N","04/22/2019","04/01/2019","03/31/2020","113","P30ES009089","SCHOOLS OF PUBLIC HEALTH","RFA-ES-17-003","5P30ES009089-21","NIEHS:1590310\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","NEW YORK","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","PUBLIC HEALTH IMPACT (Overall Component) The goal of the NIEHS Center for Environmental Health in Northern Manhattan (CEHNM) is to provide essential support for the development of critical and novel research into the environmental causes of poor health through pilot projects, a career development program, multidisciplinary research working groups, and facility cores. The CEHNM has been very successful in achieving this goal by advancing member?s capacity to obtain research funding, attracting new investigators to the center and helping members establish themselves as leaders in environmental health science and public health. For this competitive renewal, we propose a new organization of our research themes, novel directions for future activities, new augmented services, advanced community engagement activities, and renewed leadership to ensure that CEHNM will continue to respond to the most urgent local and global public health needs of our times.","8651962; ","BACCARELLI, ANDREA ;","THOMPSON, CLAUDIA L","07/01/1998","03/31/2023","Address; Advocacy; African American; Air; air monitoring; Area; Award; Bioinformatics; Biological; Biometry; career; career development; Climate; Collaborations; college; Communication; Communities; community partnership; Complement; Consultations; Core Facility; Custom; Data; data access; Data Analytics; data management; design; Development; Disease; disorder prevention; Doctor of Medicine; Doctor of Philosophy; Dust; Educational Status; Emergency Situation; Ensure; Environmental Epidemiology; Environmental Exposure; Environmental Health; environmental intervention; Epigenetic Process; Equipment; Faculty; feeding; Fostering; Funding; Future; Goals; Health; Health Sciences; Heating; Hispanic Americans; Home environment; improved; Infrastructure; innovation; Integrative Medicine; Interdisciplinary Study; interest; Intervention; Intervention Trial; Lead; Leadership; Location; Logistics; meetings; member; Mentors; Mission; Molecular; National Institute of Environmental Health Sciences; Nature; New York; novel; outreach; Physicians; Pilot Projects; Planet Earth; Policies; Population; Poverty; Prevention; Program Development; programs; Public Health; Public Health Schools; Readiness; recruit; remediation; Research; Research Design; Research Personnel; Research Project Grants; Research Training; resilience; Running; Sampling; Schools; Science; science education; Scientist; Series; Services; Soil; Specimen; Surgeon; Time; training opportunity; Translating; Translations; United States National Institutes of Health; Universities; Vehicle Emissions; Vision; Vulnerable Populations; Water; Work; working group; ","Center for Environmental Health in Northern Manhattan","009089","EHS","Environmental Health Sciences Review Committee ","","","21","1016509","573801","1590310",""
"9672445","P30","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P30ES009089","","RFA-ES-17-003","5P30ES009089-21","NIEHS:241902\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","NEW YORK","UNITED STATES","","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","","8853211; ","CHILLRUD, STEVEN N.;","","","","Address; Air; air monitoring; Air Pollution; Airborne Particulate Matter; Allergens; analytical method; Archives; Assessment tool; base; Biological; Carbon Black; Climate; Collaborations; Collection; Communities; community organizations; Complement; Consultations; Core Facility; Data; Data Analytics; Development; Disease; disorder prevention; Doctor of Philosophy; Dose; Dust; Educational Activities; Emergency Situation; Environmental Epidemiology; Environmental Health; Epigenetic Process; Equipment; Exposure to; Fostering; Funding; fungus; Gases; Goals; Health; Health Sciences; Hearing; improved; Information Dissemination; Infrastructure; Inhalation; instrumentation; Integrative Medicine; Investigation; Isotopes; Laboratories; Maintenance; member; Mentors; method development; Methods; Mission; National Institute of Environmental Health Sciences; outreach; Particulate Matter; Peer Review; Pilot Projects; Postdoctoral Fellow; Public Health; Publications; ranpirnase; Research; Research Design; Research Personnel; Research Project Grants; response; Sampling; Science; Services; Soil; soil sampling; Source; Students; success; Testing; Time; Training; Translations; Universities; Validation; volatile organic compound; Water; water sampling; Work; working group; ","Exposure Assessment Facility Core","009089","EHS","Environmental Health Sciences Review Committee ","7564","","21","151189","90713","","241902"
"9672448","P30","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P30ES009089","","RFA-ES-17-003","5P30ES009089-21","NIEHS:150457\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","NEW YORK","UNITED STATES","","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","","10807240; ","HERNANDEZ, DIANA ;","","","","Address; Advocacy; Area; base; Broadcast Media; Cities; Climate; Collaborations; Communication; Communication Methods; Communications Media; Communities; Community Health; Country; design; digital; Disadvantaged; Doctor of Philosophy; Education; Education and Outreach; Educational Status; Emergency Situation; Environmental Health; environmental justice; Fostering; Government Agencies; Health Personnel; Health Policy; Hearing; Heating; Home environment; improved; innovation; International; Intervention; Leadership; medically underserved; member; Modeling; news; novel; organizational structure; outreach; Persons; Plant Roots; Policies; Policy Maker; Population; Prevention; Printed Media; programs; Public Health; Public Health Schools; Readiness; Relationship-Building; Research; Research Personnel; Research Project Grants; Research Training; resilience; Science; Sister; sound; Students; synergism; Technology; Time; Training; training opportunity; Translating; Translations; Universities; Vehicle Emissions; Vision; Vulnerable Populations; Work; working group; ","Community  Engagement Core","009089","EHS","Environmental Health Sciences Review Committee ","7566","","21","116601","33856","","150457"
"9676316","P30","ES","5","N","04/26/2019","04/01/2019","03/31/2020","113","P30ES027792","SCHOOLS OF MEDICINE","RFA-ES-16-001","5P30ES027792-03","NIEHS:946911\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","CHICAGO","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","OVERALL NARRATIVE We propose to establish ?ChicAgo Center for Health and EnvironmenT (CACHET)? ? the first NIEHS P30 environmental health sciences core center in the Chicago area. CACHET will promote multidisciplinary environmental health research among clinician, laboratory and population scientists from two Chicago area universities with complementary strengths and structure (one private and one public) to understand, evaluate and ultimately reduce environmental health related disparities among residents of the region and beyond.","2100156 (contact); 1858732; ","AHSAN, HABIBUL  (contact); PRINS, GAIL S;","THOMPSON, CLAUDIA L","09/30/2017","03/31/2021","Address; Agreement; Air; Air Pollution; Area; Award; Biological; Biological Markers; Biology; career development; Chicago; Cities; Clinical; Collaborations; college; Communication; Communities; Community Outreach; Core Facility; Development; Disease; Disease Outcome; disorder risk; Doctor of Philosophy; Economic Factors; economic impact; Economics; effective intervention; Endocrine; Endocrine System Diseases; Ensure; Environment; environmental carcinogenesis; Environmental Exposure; Environmental Health; Environmental Impact; environmental justice; Epigenetic Process; Ethnic group; ethnic health disparity; experience; Faculty; Fertilization; Focus Groups; Fostering; Funding; Genetic; Goals; Group Structure; Health; health disparity; Health Professional; health science research; Health Sciences; Homeostasis; human disease; Human Genetics; Illinois; improved; Individual; Institutes; Institution; Integrative Medicine; inter-institutional; Interdisciplinary Study; Investigation; Laboratories; Malignant Neoplasms; Medicine; member; Metabolic; Metabolic Diseases; Mission; Modeling; multidisciplinary; National Institute of Environmental Health Sciences; novel; organizational structure; Physiology; Pilot Projects; Plant Roots; Policies; Policy Maker; pollutant; Population; Predisposition; Privatization; professor; Program Development; programs; Public Health; racial and ethnic; racial and ethnic disparities; ranpirnase; recruit; Research; Research Personnel; Resources; response; Risk; Scientist; social; Soil; soil pollution; statistics; Structure; tool; Translating; United States National Institutes of Health; Universities; urban area; Urology; Water; Water Pollution; water quality; Work; ","ChicAgo Center for Health and EnvironmenT (CACHET)","027792","ZES1","Special Emphasis Panel ","","","03","763207","183704","946911",""
"9676968","R01","HL","5","N","04/25/2019","04/01/2019","03/31/2020","838","R01HL136719","SCHOOLS OF MEDICINE","PA-16-160","5R01HL136719-03","NHLBI:779440\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PHILADELPHIA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","NARRATIVE Millions of patients with acute respiratory failure or sepsis present to U.S. emergency departments each year. For the majority of these patients who do not require life support, rates of admission to intensive care units (ICUs) or hospital wards vary considerably both among hospitals and within hospitals over time due to bed availability. This mixed-methods study in 26 hospitals across 2 health systems will leverage this among- and within-hospital practice variability to precisely characterize patients who benefit from ICU or ward admission and identify emergency department, ward, and ICU care processes that contribute to net ICU or ward benefits. Using granular electronic health record data, instrumental variable analyses, ethnography, and semi-structured interviews, our results will improve outcomes for these acutely ill patients by enabling personalized triage.","9610328; ","HALPERN, SCOTT D;","REINECK, LORA A","04/01/2017","03/31/2021","Accident and Emergency department; Acute; Acute respiratory failure; Admission activity; Adult Respiratory Distress Syndrome; Algorithms; American; base; Beds; California; care costs; Caring; Cessation of life; Characteristics; Data; Decision Aid; Delirium; Electronic Health Record; Emergency Department patient; Ethnography; evidence base; Future; Goals; Grant; Health system; Healthcare Systems; Heart failure; high risk; Hospitals; Hour; improved; improved outcome; individual patient; informant; innovation; instrument; Integrated Health Care Systems; Intensive Care Units; Interview; Length of Stay; Life; Measures; Methodology; Methods; Modeling; Monitor; mortality; Nurses; Outcome; Patient Admission; Patient Triage; Patient-Focused Outcomes; Patients; Pennsylvania; Phenotype; Pneumonia; prevent; Probability; Process; Protocols documentation; Public Health; Pulmonary Embolism; Qualitative Methods; Quality of Care; Recommendation; respiratory; Risk Factors; Sepsis; septic patients; Structure; Testing; Time; Triage; United States; Universities; ward; Work; working group; ","Benefits of ICU admission for patients with acute respiratory failure or sepsis: A mixed-methods study across 26 hospitals","136719","HSOD","Health Services Organization and Delivery Study Section ","","","03","592848","186592","779440",""
"9677122","U24","CA","5","N","04/24/2019","04/01/2019","03/31/2020","394","U24CA196175","","RFA-CA-14-501","5U24CA196175-05","NCI:2695810\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","COLUMBUS","UNITED STATES","","03","147212963","US","1495302","RESEARCH INST NATIONWIDE CHILDREN'S HOSP","OH","432052664","PUBLIC HEALTH RELEVANCE: Cancer research is dependent on the availability of high quality biospecimens linked to patient information from clinical trials. The SWOG Biospecimen Bank collects, processes, banks and distributes biospecimens from adult cancer patients enrolled on NCI-sponsored clinical trials. These biospecimens are eventually used by researchers studying different types of cancer. The results of the research benefits patients by, among other things, contributing to the development of new cancer treatments and to the improvement of patient care.","8551999; 8769686; 7704642 (contact); ","GASTIER-FOSTER, JULIE M; RAE, JAMES MICHAEL; RAMIREZ MILAN, NILSA DEL CARMEN (contact);","MAKHLOUF, HALA","04/23/2015","03/31/2020","Address; Adult; anticancer research; base; biobank; Breast; cancer clinical trial; Cancer Patient; cancer therapy; cancer type; Clinical; Clinical Data; Clinical Medicine; Clinical Research; Clinical Treatment; Clinical trial protocol document; Clinical Trials; Clinical Trials Information for Patients; Collection; Colon; Component of the National Cancer Institute; Data; design; Development; Diagnostic; Disease; Enrollment; Ensure; Epidemiology; follow-up; Guidelines; Health; Human; Infrastructure; innovative technologies; Laboratories; laboratory equipment; leukemia; Link; Lung; Lymphoma; Malignant Neoplasms; melanoma; Molecular Biology; Molecular Profiling; Multiple Myeloma; National Cancer Institute; National Clinical Trials Network; Operative Surgical Procedures; Pathologic; Patient Care; Patients; Pediatric Hospitals; Procedures; Process; programs; Prostate; Protocols documentation; public health relevance; Reporting; Research; Research Personnel; Residual state; Resources; Sampling; Services; Southwest Oncology Group; Specimen; Therapeutic; translational medicine; Translational Research; Treatment Protocols; treatment trial; tumor; Tumor Bank; Work; ","SWOG Biospecimen Bank","196175","ZCA1","Special Emphasis Panel ","","","05","2223269","472541","2695810",""
"9679492","K01","DK","5","N","04/09/2019","04/25/2019","04/24/2020","847","K01DK110225","SCHOOLS OF MEDICINE","PAR-16-211","5K01DK110225-03","NIDDK:111666\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","SAINT LOUIS","UNITED STATES","OBSTETRICS & GYNECOLOGY","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","Project Narrative Recurrent urinary tract infection (rUTI) is a common and costly clinical problem, affecting millions of women in the U.S. and worldwide. We have found that the bacterium Gardnerella vaginalis triggers rUTI. This project seeks to understand how G. vaginalis causes rUTI and to determine whether G. vaginalis could serve as a biomarker of rUTI risk in women.","10594584; ","GILBERT, NICOLE MARIE;","RANKIN, TRACY L","04/25/2017","04/24/2022","Abscess; acute infection; Acute Renal Failure with Renal Papillary Necrosis; Address; Affect; Agonist; Antibiotic Resistance; Apoptosis; Apoptotic; Area; Automobile Driving; Bacteria; Bacterial Infections; Bacterial Vaginosis; base; Biological Factors; Biological Markers; Biometry; Bladder; career; career development; career networking; Caspase Inhibitor; Cells; Cellular Stress; Chemicals; Clinical; Clinical Research; Clinical Sciences; co-infection; Coitus; Communicable Diseases; cost; cytokine; Data; Disease; Educational process of instructing; Epithelium; Escherichia coli; experimental study; Exposure to; Faculty; Frequencies; Gardnerella vaginalis; Genitourinary system; Goals; Grant; Human; Immune; Immune response; Infection; Infective cystitis; Inflammatory Response; Inflammatory Response Pathway; innovation; Institutes; Instruction; Interview; Journals; Kidney; kidney infection; Laboratories; Language; Learning; Life; Manuscripts; Medical Research; medical schools; meetings; member; Mentored Research Scientist Development Award; Mentors; microbiota; Modeling; Molecular; mouse model; Mus; Nested Case-Control Study; neutrophil; novel; Nuclear Orphan Receptor; Occupations; pathogen; Peer Review; Population; Pregnancy; Prevalence; Procedures; Proteins; Publications; Recurrence; Research; Research Design; Research Ethics; Research Personnel; Research Proposals; Research Training; response; Risk; Risk Factors; Role; sexually active; skills; Specimen; Symptoms; Systemic infection; Testing; Tissues; Training; Training Activity; Transcript; transcriptome sequencing; Translating; Translational Research; United States National Institutes of Health; Universities; Urethra; Urinary tract; Urinary tract infection; Urine; Urologic Diseases; Urology; Urothelium; Vagina; vaginal infection; vaginal microbiota; Washington; Woman; Writing; ","Role of Gardnerella vaginalis in the Urinary Tract","110225","DDK","Digestive Diseases and Nutrition C Subcommittee ","","","03","103394","8272","111666",""
"9685047","R01","HD","5","N","04/24/2019","04/01/2019","03/31/2020","865","R01HD083930","PRIMATE CENTERS","PA-13-302","5R01HD083930-04","NICHD:588107\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","PORTLAND","UNITED STATES","OBSTETRICS & GYNECOLOGY","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","PUBLIC HEALTH RELEVANCE: While improvements in the diagnosis and treatment of cancers have led to a 75% survival rate in young patients, devastating side effects of chemo- or radiotherapies leave survivors facing infertility due to ovarian failure and adverse health effects associated with premature menopause. Clinics worldwide are cryopreserving ovarian tissue since this is the only current option for prepubertal, adolescent and young women with cancer with hopes that this tissue can be used in the future, but techniques to restore ovarian function and fertility are still experimental. Recent advances in cryobiology, transplantation and follicle culture are emerging from preclinical research in nonhuman primates that now allow systematic investigations to improve and inform clinical practice so girls and young women can be offered the best chances of becoming mothers after surviving cancer.","2092816; ","ZELINSKI, MARY B;","TAYMANS, SUSAN","06/06/2016","03/31/2021","3-Dimensional; Adolescent; Adolescent and Young Adult; Adult; Adverse effects; Age; Antral; Autologous; Autologous Transplantation; Benign; Biomedical Engineering; Birth; Blood flow; Blood Vessels; Bone Marrow Transplantation; Breast Cancer Patient; cancer cell; cancer invasiveness; Cancer Survivor; cancer therapy; cell type; chemotherapy; Child; child bearing; childhood cancer survivor; Clinic; Clinical; clinical practice; clinical translation; Complex; Computer Simulation; contrast enhanced; Controlled Study; Cortex of ovary; cryobiology; Cryopreservation; Detection; Development; Diagnosis; Disease; Embryo; Embryology; Embryonic Development; Encapsulated; Endocrine; Environment; experience; Exposure to; FDA approved; Female; Fertility; fertility preservation; Fibrin; Foundations; Freezing; functional outcomes; Future; Germ Cells; girls; Goals; Health; Heterotopic Transplantation; Human; improved; In Vitro; in vivo; Individual; Infertility; innovative technologies; Interruption; Investigation; Investigational Therapies; Late Effects; Macaca mulatta; Malignant Neoplasms; Menopause; Methods; Modeling; Mothers; Non-Malignant; nonhuman primate; novel; novel strategies; offspring; Oocytes; Ovarian; ovarian failure; Ovarian Tissue; Ovarian tissue cryopreservation; Ovary; ovary transplantation; Parents; Patients; Population; pre-clinical research; preimplantation; Premature Menopause; Premature Ovarian Failure; prepuberty; Prior Therapy; Production; Protocols documentation; public health relevance; Radiation; Radiation therapy; Regulation; Reporting; Reproducibility; Research Personnel; restoration; Risk; Running; Safety; scaffold; Site; sound; Source; steroid hormone; Stromal Cells; Survival Rate; Survivors; System; Techniques; Technology; Tissues; tool; Translations; Transplantation; Transplanted tissue; treatment effect; Ultrasonography; vascular bed; Woman; young adult; young woman; ","Cryopreservation and Transplantation of Ovarian Cortical Tissue for Fertility Preservation","083930","ICER","Integrative and Clinical Endocrinology and Reproduction Study Section ","","","04","352782","235325","588107",""
"9687719","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:174778\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","CORE E: PROJECT NARRATIVE Our Center's novel `seeing the whole picture' exposomic approach will assess the health risks of hazardous sites by generating high-dimensional biological and exposure data in human biospecimens, water and soil samples and cell-lines, using cell-based bioassays, sequencing and analytical chemistry approaches. Core E, the Data Science and Laboratory Core will support: (a) the acquisition, storage, analysis, and sharing of large, complex datasets; and (b) a carefully-maintained biorepository of human biospecimens and cell lines, as well as bioassay and analytical capabilities, to support these goals.","8951736; ","HUBBARD, ALAN E;","","","","Address; Affect; Analytical Chemistry; Area; Arsenic; Back; base; Benzene; Benzo(a)pyrene; biobank; Bioinformatics; bioinformatics tool; Biological; Biological Assay; Biological Markers; Biological Process; Biometry; Blood; California; Cell Culture Techniques; Cell Line; Cells; Chemicals; Chlorinated Hydrocarbons; Chromium; Communities; Complex; Computational Biology; computer infrastructure; Consultations; cost effective; Cryopreserved Cell; Data; Data Analyses; data archive; Data Science; Data Set; Development; drinking water; Endocrine; Engineering; Environment; Environmental Exposure; exposed human population; Exposure to; Formaldehyde; functional genomics; Generations; genomic data; Genomics; Goals; Hazardous Waste Sites; Health; high dimensionality; Human; improved; In Vitro; Infrastructure; innovation; Intervention; Intervention Studies; Laboratories; learning strategy; Linux; Machine Learning; Mammalian Cell; Mass Spectrum Analysis; Measurement; Measures; Metadata; Methodology; Methods; microbial; microbial community; Nitrates; novel; Online Systems; Pattern; Pesticides; Poisons; Population; Process; professor; programs; Protocols documentation; Research; Research Personnel; Research Project Grants; Resources; Risk; Sampling; semiparametric; sharing data; Site; Soil; soil sampling; Specimen; success; superfund chemical; System; Techniques; Technology; Time; tool; tool development; Training; Trichloroethylene; Urine; Water; water quality; water sampling; web-based tool; Work; ","Core E: Data Science and Laboratory Core","004705","ZES1","Special Emphasis Panel ","5067","","31","114651","60127","","174778"
"9687726","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:310283\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","PROJECT 4: NARRATIVE Because cancers are caused by reactive metabolic products of some Superfund chemicals, we developed a technology, called `adductomics', that measures signatures (`adducts') of these reactive products in blood. By measuring adductomes in blood from subjects with documented exposures to three carcinogenic Superfund chemicals (benzene, arsenic and PAHs), we will find their adduct signatures. Then we will measure the adduct signatures in cancer cases and controls to determine whether these Superfund chemicals contributed to cancer risks.","8864731; ","RAPPAPORT, STEPHEN MORRIS;","","","","Address; adduct; Air Pollution; Archives; Arsenic; Benzene; Benzene Exposure; Biological Assay; Biological Markers; Blood; Blood Proteins; Cancer Etiology; cancer risk; carcinogenicity; case control; Chemicals; Chile; China; Cohort Studies; contaminated drinking water; Cross-Sectional Studies; Diet; Disease; disorder risk; Disulfides; Environment; environmental stressor; Exposure to; Glean; Health; Hematopoietic Neoplasms; Human; human DNA; Ingestion; Inhalation; insight; Investigation; Laboratories; Libraries; Link; Lymphoid; Malignant neoplasm of lung; Malignant Neoplasms; Measurement; Measures; Metabolic; Metabolic Pathway; Metabolism; Myelogenous; National Cancer Institute; Obesity; Occupational Exposure; oxidation; Oxidative Stress; Oxides; Pathway interactions; Pattern; Plasma; Poisons; Population Study; Post-Translational Protein Processing; prospective; Prospective Studies; Proteins; Proteomics; Psychosocial Stress; Reaction; Reactive Oxygen Species; Risk; Risk Factors; Sampling; Serum; Serum Albumin; Source; study population; Sulfhydryl Compounds; Superfund; superfund chemical; Technology; Toxic effect; toxicant; Woman; Women's Health; ","Project 4: Using Adductomic Signatures to Evaluate Risks of Superfund Chemicals","004705","ZES1","Special Emphasis Panel ","5071","","31","198350","111933","","310283"
"9687728","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:275563\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","PROJECT 6: PROJECT NARRATIVE Arsenic, chlorinated solvents and aromatic hydrocarbons are frequently detected as mixtures in groundwater aquifers that represent a hazard to public health and the environment. This project will apply systems biology approaches to study interactions within microbial communities involved in the bioremediation of groundwater mixtures containing arsenic species in combination with other chemicals.","12019380; ","ALVAREZ-COHEN, LISA ;","","","","Address; Anaerobic Bacteria; Aromatic Hydrocarbons; Arsenic; Bacteriophages; base; Benzene; Bioinformatics; Biological; Biological Availability; Biological Markers; Bioremediations; Chemicals; Communities; Complex; CRISPR/Cas technology; dechlorination; Degradation Pathway; design; drinking water; Electrons; Elements; Engineering; Environment; Environment and Public Health; environmental enrichment for laboratory animals; ethylbenzene; experimental study; Gene Expression; Genes; genetic manipulation; genome editing; ground water; hazard; Hazardous Substances; Hazardous Waste Sites; Heavy Metals; Immobilization; improved; Individual; Infrastructure; Injections; Investigation; Kinetics; Knowledge; Lead; Metabolic; Metabolic Pathway; metabolomics; Metagenomics; Metals; metatranscriptomics; Microbe; microbial community; microbiota; microorganism; microorganism interaction; Modeling; Modernization; Molecular; multiple omics; operation; organic contaminant; Organism; Oxidants; Oxidation-Reduction; Oxygen; Pathway interactions; Physiological; Poisons; Precipitation; predictive tools; Process; Production; remediation; Reporting; Research; Research Personnel; Resistance; response; Role; Signal Recognition Particle; Site; Solvents; Structure; Superfund; superfund site; System; Systems Biology; Technology; Testing; Toluene; tool; Toxic effect; treatment optimization; treatment strategy; Trichloroethylene; water quality; Water Supply; Xylene; ","Project 6: Microbial Communities that Bioremediate Chemical Mixtures","004705","ZES1","Special Emphasis Panel ","5073","","31","178971","96592","","275563"
"9692750","R25","HL","5","N","04/22/2019","04/01/2019","03/31/2020","837","R25HL108837","SCHOOLS OF MEDICINE","RFA-HL-16-008","5R25HL108837-08","NHLBI:238829\","OTHER RESEARCH-RELATED","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","TUCSON","UNITED STATES","SURGERY","03","806345617","US","490201","UNIVERSITY OF ARIZONA","AZ","857210158","This renewal proposal is continuing and further enhancing an innovative program to recruit, train and mentor a large number of diverse/disadvantaged (including URM) undergraduates and medical students in biomedical research predominantly targeting heart, lung, blood disorders. We are building a continuous career pipeline to promote retention and career progression, thereby contributing to the NIH Strategic Plan of creating the diverse clinical research teams of the future and advancing translation of medical discoveries from bench to bedside to community.","1880888; ","WITTE, MARLYS HEARST;","MEADOWS, TAWANNA","04/01/2017","03/31/2022","Advisory Committees; Area; Arizona; Asthma; Attitude; base; Basic Science; bench to bedside; Biocompatible Materials; Bioinformatics; Biology; Biomedical Engineering; Biomedical Research; Blood; Brain; Car Phone; Cardiac; Cardiovascular system; career; Clinical; clinical investigation; Clinical Research; college; Communication; Communities; Complex; Computer Simulation; Critical Thinking; Curiosities; Cystic Fibrosis; Databases; design; Development; Development Plans; Disadvantaged; disadvantaged population; Disease; Educational Curriculum; Educational workshop; Effectiveness; Environmental air flow; Equilibrium; Esapent; Evaluation; experience; Faculty; faculty mentor; Fostering; Future; Genomics; Goals; Health; Health Professional; Healthcare; Heart; Hematological Disease; High School Student; Hypertrophy; Image; In Situ; In Vitro; in vivo; Individual; Infrastructure; innovation; Institution; Interdisciplinary Study; interest; International; Knowledge; Laboratories; Leadership; Link; Longterm Follow-up; Lung; lymphology; Medical; Medical Research; Medical Students; medically underserved population; Medicine; Mentors; metabolomics; Mission; Modeling; Molecular Medicine; Monitor; Multimedia; National Heart, Lung, and Blood Institute; Natural regeneration; Nature; Neurosciences; online course; Participant; peer; peer coaching; peer networks; Physicians; Physiology; Productivity; professor; programs; Prosthesis; Proteomics; Public Health; Pulmonary Hypertension; Pulmonology; Ramp; Reaction; recruit; Registries; Research; Research Methodology; Research Personnel; Respiration Disorders; role model; Science; skills; Specialized Center; stem cell biology; Strategic Planning; student mentoring; student training; Students; summer institute; summer program; support network; Technology; Time; Training; Training Programs; Translating; Translation Process; translational scientist; Translations; undergraduate student; Underrepresented Minority; United States National Institutes of Health; Universities; virtual; Visit; ","Short-Term Training to Increase the Diversity Pipeline in Heart/Lung/Blood Research","108837","ZHL1","Special Emphasis Panel ","","","08","221138","17691","238829",""
"9693547","R01","AI","1","N","04/24/2019","04/25/2019","03/31/2020","855","R01AI143333","SCHOOLS OF MEDICINE","PA-18-484","1R01AI143333-01","NIAID:623206\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BALTIMORE","UNITED STATES","NONE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Measuring the impact of interventions to treat and prevent new HIV infections in Africa is difficult because there are persons who are hard to reach through standard surveys. These persons may also be hard to reach with typical HIV treatment and prevention interventions. This study will use intensive tracking methods to find and survey these hard to reach people, determine how engaged they are in HIV treatment and prevention, and assess what their role is in ending the HIV epidemic.","9565751; ","CHANG, LARRY WILLIAM;","BACON, MELANIE C","04/25/2019","03/31/2023","Acquired Immunodeficiency Syndrome; Address; Africa; African; AIDS prevention; antiretroviral therapy; Area; Car Phone; Censuses; Characteristics; Cohort Studies; Communities; Cross-Sectional Studies; Data; demographics; Environment; Epidemic; Epidemiology; Evaluation; Family; follow-up; Future; Goals; high risk; high risk population; HIV; HIV Infections; HIV prevention trial; HIV Seropositivity; Home visitation; Incidence; Individual; innovation; Intervention; Male Circumcision; Measures; Methods; Modeling; novel; Participant; Partner Notification; Pathway Analysis; Pathway interactions; Patient Self-Report; Persons; Phylogenetic Analysis; Population; population based; Population Decreases; Population Study; Positioning Attribute; pre-exposure prophylaxis; Prevalence; prevent; Prevention; Preventive Intervention; programs; prospective; Randomized; recruit; Reporting; Research Infrastructure; Role; Sampling; scale up; Schools; Services; Sex Behavior; Source; Structure; Surveys; Techniques; Testing; transmission process; Travel; Uganda; Viral; Viral Load result; Work; ","Hard-to-Reach Populations: Implications for Ending the AIDS Epidemic","143333","ACE","AIDS Clinical Studies and Epidemiology Study Section ","","","01","499687","123519","623206",""
"9695974","R01","DK","5","N","04/26/2019","04/01/2019","03/31/2020","847","R01DK108803","SCHOOLS OF MEDICINE","PAR-12-265","5R01DK108803-04","NIDDK:577734\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BALTIMORE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","PUBLIC HEALTH RELEVANCE: Chronic kidney disease (CKD) disproportionately affects African Americans. Recent studies have identified two African-specific genetic variants which may explain much of the ethnic differences in CKD risk. Understanding gene function, and in particular the metabolomic intermediates which may be targeted by interventions, can provide critical information that will lead to reductions in CKD incidence and progression among African Americans.","10586344; ","GRAMS, MORGAN ERIKA;","PARSA, AFSHIN","06/13/2016","03/31/2021","Affect; African; African American; Albuminuria; Apolipoproteins; base; Bile Acids; Bilirubin; Biological; Caring; Caucasians; Cell physiology; Cessation of life; Chronic Kidney Failure; Clinical; cohort; Collection; Cresol; Critical Pathways; Data; design; Disease Outcome; Disease Progression; Disease susceptibility; disorder prevention; disorder risk; End stage renal failure; Erythrocytes; ethnic difference; Ethnic group; Etiology; Evaluation; follow-up; gene function; General Population; Genes; Genetic; Genetic Determinism; Genetic Risk; genetic risk factor; genetic variant; Genetic Variation; genome wide association study; genomic data; Genomics; Genotype; Glomerular Filtration Rate; high risk; Hypertension; improved; Incidence; Indican; Intervention; Kidney; Kidney Diseases; Knowledge; Lead; Link; Longitudinal Studies; Mediating; Mediator of activation protein; Medical; Metabolism; metabolomics; Methods; modifiable risk; mortality; Mutation; New York City; novel; Outcome; Outpatients; Participant; Pathogenicity; Pathologic Processes; Pathway interactions; Patients; Pattern; Phenotype; Pilot Projects; Population; Process; public health relevance; racial disparity; Randomized; Renal function; Research; Resources; Risk; Risk Factors; risk variant; Role; Sampling; Sickle Cell; Sickle Cell Trait; targeted treatment; Techniques; Toxin; Unspecified or Sulfate Ion Sulfates; Variant; Visit; Work; ","Metabolomics and Genomics in African Americans with CKD","108803","ZDK1","Special Emphasis Panel ","","","04","395000","182734","577734",""
"9700672","P41","EB","5","N","04/26/2019","03/01/2019","02/29/2020","","P41EB015922","","PAR-17-083","5P41EB015922-22","NIBIB:259186\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","Los Angeles","UNITED STATES","","34","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PROJECT NARRATIVE - TR&D1: DATA SCIENCE Large-scale analyses of neuroscientific information require an environment where data from multiple research studies around the world can be easily discovered, aggregated, and reused. Independent and geographically separated data sets must be harmonized into large sample sizes and scientific analyses must be executed, quality-checked, and accurately recorded to be shared and reproduced by others. Our proposed framework lays a foundation for reproducible science through reliable data provenance and federated data analyses.","6855806; ","TOGA, ARTHUR W;","","","","Agreement; Architecture; Archives; Biomedical Research; Client; Communities; Complex; Computer software; Computers; computing resources; Coupled; Data; data access; Data Aggregation; Data Analyses; Data Files; data management; Data Provenance; Data Science; Data Set; Databases; design; Dictionary; Docking; Drops; Environment; experience; Eye Movements; federated computing; Foundations; Functional Magnetic Resonance Imaging; Geography; Goals; Graph; Image; Imagery; Institution; interactive tool; interest; Internet; Laboratories; Link; Linux; Literature; Machine Learning; Magnetic Resonance Imaging; Measures; Mediator of activation protein; Morphologic artifacts; Motion; neural network; neuroimaging; Neurosciences; novel strategies; One-Step dentin bonding system; Online Systems; Operating System; operation; Output; Participant; Pathway interactions; Process; Quality Control; Radiology Specialty; Records; Registries; Reporting; Reproducibility; Research; Research Personnel; research study; Resources; Running; Sample Size; Science; Secure; Services; Source; supervised learning; System; T2 weighted imaging; Technology; Time; tool; Training; Update; Visual; visual feedback; web-accessible; ","TR&D1: Data Science","015922","ZEB1","Special Emphasis Panel ","5228","","22","169242","89944","","259186"
"9701960","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:158480\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","","1892882; ","KING, GEORGE L;","","","","Adopted; Advisory Committees; Area; base; Basic Science; Biometry; Boston; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Complex; Data Analyses; Development; diabetes management; Diabetes Mellitus; driving force; Due Process; Education; Effectiveness; Ensure; Environment; Equipment; Face; Faculty; Goals; Grant; Information Technology; Infrastructure; innovation; Institution; Laboratories; Laboratory Research; Leadership; Medical; medical schools; Metabolic; Metabolism; Obesity; operation; Outcomes Research; Productivity; programs; Publications; recruit; Research; Research Infrastructure; Research Personnel; Resources; Science; Services; Structure; Technology; Transact; Translating; Translational Research; Universities; Vision; ","Administrative Core","036836","ZDK1","Special Emphasis Panel ","7090","","33","93914","64566","","158480"
"9702547","P40","OD","2","N","04/22/2019","04/22/2019","03/31/2020","351","P40OD010952","SCHOOLS OF ARTS AND SCIENCES","PAR-17-006","2P40OD010952-24","OD:565533\","RESEARCH CENTERS","2019","OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH","","KEY BISCAYNE","UNITED STATES","BIOLOGY","27","152764007","US","10011242","UNIVERSITY OF MIAMI ROSENTEIL SCHOOL","FL","331491031","The California sea hare, Aplysia californica, is a large marine snail that has proven to be an outstanding model for studies of how the nervous system functions, particularly in memory and learning, as well as in understanding human diseases that affect these functions. The National Resource for Aplysia raises and ships 10,000 to 15,000 of these animals per year to research laboratories. This proposal would continue the production of these animals and expand their usefulness for studies of aging, lifespan extension, and mechanisms of resistance to the type of nervous system injuries encountered in stroke.","1865602; ","SCHMALE, MICHAEL C;","ZOU, SIGE","05/01/1996","03/31/2024","Adult; Affect; Age; aged; Aging; Animals; Aplysia; Aplysia species; Applied Research; base; Behavior; Biological Models; Biomedical Research; Brain Hypoxia-Ischemia; California; Caloric Restriction; cell injury; Characteristics; cohort; Communities; Complex; coping mechanism; cost; Data; Development; Diet; Disease; DNA; Education; egg; Environment; experimental study; Expression Profiling; Ganglia; Gene Expression; Genetic Transcription; Glycolysis; Goals; Harvest; Health; human disease; human subject; Hypoxia; improved; Injury; insight; Laboratory Research; Learning; Life; Life Cycle Stages; Longevity; Malnutrition; Marines; Memory; Metabolic; Mission; Mitochondria; Modeling; Molecular; Monitor; Nervous System Physiology; Nervous system structure; Nervous System Trauma; Neurons; neurophysiology; novel; Pathway interactions; Pattern; Phase; Phenotype; Photoperiod; Physiological; Physiology; Play; Production; programs; Protocols documentation; Reflex action; Reperfusion Injury; reproductive; Research; Research Personnel; Research Project Grants; resilience; Resistance; resistance mechanism; Resources; RNA; Role; Sales; Sampling; screening; senescence; Services; Ships; Siblings; Snails; Stroke; stroke model; Study models; Syndrome; Temperature; Time; Tissues; transcriptome sequencing; transcriptomics; Universities; water quality; ","National Resource for Aplysia","010952","ZRG1","Special Emphasis Panel ","","","24","364860","200673","565533",""
"9702795","P30","DK","5","N","04/24/2019","04/01/2019","03/31/2020","","P30DK057521","","RFA-DK-13-004","5P30DK057521-20","NIDDK:104400\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","","1931295; ","MARKMANN, JAMES F;","","","","Allogenic; Area; arm; Autoimmunity; Autologous; base; Beta Cell; Biology; Boston; Cell Proliferation; Clinical; Clinical Research; Communities; Complement; Consent; cost; design; Development; Diabetes Mellitus; Effectiveness; Endocrinology; Funding; Goals; Health Services Accessibility; Human; improved; Infrastructure; Investigation; islet; Islet Cell; Islets of Langerhans; Islets of Langerhans Transplantation; Laboratories; manufacturing facility; manufacturing process; member; New England; Non-Insulin-Dependent Diabetes Mellitus; Organ; Phase III Clinical Trials; phase III trial; Physiology; Preparation; Process; Production; programs; Protocols documentation; Research; Research Personnel; Research Support; Resources; Scientist; Site; Source; Standardization; Surveys; Technology; Time; Transplantation; United States National Institutes of Health; Work; ","Human Islet Core","057521","ZDK1","Special Emphasis Panel ","7735","","20","60000","44400","","104400"
"9702796","P30","DK","5","N","04/24/2019","04/01/2019","03/31/2020","","P30DK057521","","RFA-DK-13-004","5P30DK057521-20","NIDDK:386579\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","","1878593; ","HABENER, JOEL F;","","","","Area; base; Boston; career; Climate; Data; Diabetes Mellitus; Endocrinology; Environment; follow-up; Foundations; Funding; Goals; Grant; high risk; innovation; Investigation; Knowledge; Process; programs; Recording of previous events; recruit; Research; Research Personnel; Research Proposals; Scientist; Seeds; success; Talents; Therapeutic; Training; United States National Institutes of Health; ","Pilot and Feasibility Program","057521","ZDK1","Special Emphasis Panel ","7736","","20","222172","164407","","386579"
"9703507","P01","HL","1","N","04/22/2019","04/01/2019","03/31/2020","","P01HL146358","","PAR-18-405","1P01HL146358-01","NHLBI:458790\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","7927792; ","BENSINGER, STEVEN J;","OLIVE, MICHELLE","","","Address; Affect; Anti-inflammatory; Arterial Fatty Streak; atherogenesis; Atherosclerosis; Attenuated; base; Binding; Biochemical; Cardiovascular Diseases; Cell membrane; Cell physiology; Cells; Cellular Immunity; chemoproteomics; Cholesterol; Cholesterol Homeostasis; cholesterol trafficking; cytokine; Cytosol; Data; Dendritic Cells; design; Development; Disease; Dyslipidemias; Ensure; Event; expectation; fatty acid biosynthesis; Genes; Genetic Models; Goals; Gram-Positive Bacteria; Health; Homeostasis; human disease; Image; Immune; immune function; Immunity; Immunologic Receptors; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Interferon-beta; Interferons; Isotope Labeling; Isotopes; Laboratories; Link; lipid metabolism; lipid transport; Lipids; loss of function; macrophage; Mass Spectrum Analysis; Membrane; Metabolic; Mitochondria; Modeling; Molecular; mouse model; Movement; Mus; Mutation; novel; novel strategies; Pathogenesis; Pathologic; Pathway interactions; Physiology; Positioning Attribute; Production; Proteins; Reagent; Regulation; response; Role; Shotguns; Signal Pathway; Signal Transduction; Sterility; Techniques; Technology; Testing; Therapeutic Intervention; TLR2 gene; TLR3 gene; Toll-like receptors; Tracer; trafficking; viral RNA; Work; ","Macrophage Lipid Homeostasis and Inflammatory Signaling","146358","HLBP","Heart, Lung, and Blood Initial Review Group ","7806","","01","300000","158790","","458790"
"9733706","R21","HG","1","N","04/23/2019","04/23/2019","03/31/2020","172","R21HG010548","BIOMED ENGR/COL ENGR/ENGR STA","RFA-HG-18-002","1R21HG010548-01","NHGRI:306007\","Non-SBIR/STTR RPGs","2019","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","SANTA CRUZ","UNITED STATES","ENGINEERING (ALL TYPES)","20","125084723","US","577510","UNIVERSITY OF CALIFORNIA SANTA CRUZ","CA","950641077","Project Narrative The objective of the proposed study will be to enable high throughput sequencing of long reads with high consensus base accuracy, necessary to dramatically improve phased, linear assemblies of repeat-rich regions. The technologies developed will guide efforts to complete chromosome-scale assemblies and will institute new studies of sequence variation in repetitive DNAs.","11569605; ","MIGA, KAREN HAYDEN;","SMITH, MICHAEL","04/23/2019","03/31/2021","Alleles; arm; base; Base Sequence; Benchmarking; Biomedical Research; Cell Line; Centromere; Chromosome Structures; Chromosomes; cohort; Complex; Consensus; cost effective; CRISPR/Cas technology; Data; Data Set; design; Diploidy; Disease; DNA; DNA Modification Process; genetic pedigree; Genetic study; Genetic Variation; Genome; Genome Stability; Genomics; Goals; Health; High-Throughput Nucleotide Sequencing; Human; Human Chromosomes; Human Genome; human reference genome; Immunoglobulin Variable Region; improved; Individual; Institutes; Length; Maps; method development; Methods; Mutation; nanopore; novel; novel strategies; Phase; Platinum; reference genome; Repetitive Sequence; Research; Resolution; Resources; RNA; sequencing platform; Source; Structure; Technology; telomere; Testing; tool; Utah; Variant; Work; X Chromosome; X Inactivation; ","IMPROVING THROUGHPUT OF LONG READS WITH HIGH CONSENSUS BASE ACCURACY TO RESOLVE REPETITIVE DNAS","010548","ZHG1","Special Emphasis Panel ","","","01","200000","106007","306007",""
"9736143","R21","HG","1","N","04/23/2019","04/23/2019","01/31/2020","172","R21HG010559","SCHOOLS OF MEDICINE","PA-18-489","1R21HG010559-01","NHGRI:227309\","Non-SBIR/STTR RPGs","2019","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","DAVIS","UNITED STATES","BIOCHEMISTRY","03","047120084","US","577503","UNIVERSITY OF CALIFORNIA AT DAVIS","CA","956186153","! NARRATIVE Many diseases such as cancers, cardiovascular disease and mental disorders involve a large component of altered epigenetic modifications. If we are to gain the ability to precisely manipulate the epigenetic layer of gene regulatory information for the study and treatment of human disease, we need to develop tools for targeted epigenome editing. The aim of this project is to identify criteria for successful and long-term epigenome editing: 1) the initial epigenetic state of the target locus and 2) the available cellular factors in the target cell for persitence. !","6878121; ","SEGAL, DAVID J;","PAZIN, MICHAEL J","04/23/2019","01/31/2021","base; Cardiovascular Diseases; Cells; Chromatin; Complex; Coupled; CRISPR screen; CRISPR/Cas technology; Data; Decitabine; Development; Dimensions; Disease; DNA Methylation; Engineering; Environment; Epigenetic Process; epigenome; ERBB2 gene; Experimental Designs; Flow Cytometry; Foundations; Gene Expression Regulation; Gene Silencing; Gene Targeting; Genes; Genetic Transcription; Genome; genome-wide; Genomics; Guide RNA; histone modification; human disease; innovation; insight; knock-down; Knock-out; Lead; Location; Malignant Neoplasms; Mental disorders; Modification; nervous system disorder; nuclease; Pathway interactions; Pharmaceutical Preparations; Process; promoter; Regulator Genes; Regulatory Element; screening; System; Testing; tool; Vorinostat; ","Determinants of Persistence in Epigenetic Editing","010559","TAG","Therapeutic Approaches to Genetic Diseases Study Section ","","","01","150000","77309","227309",""
"9744315","K01","MH","1","N","04/22/2019","04/22/2019","03/31/2020","242","K01MH117443","SCHOOLS OF MEDICINE","PA-18-369","1K01MH117443-01A1","NIMH:179981\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","NEW YORK","UNITED STATES","PSYCHIATRY","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","The proposed research is relevant to public health because nearly 40% of children worldwide experience adversities, including physical and sexual abuse, poverty, and parental death, and these adversities may account for nearly a third of adult mental disorders. The research career made possible by this K01 award will help to generate new evidence about maternal childhood adversity and biological and behavioral pathways of intergenerational transmission of mental health risk. This research career will help to inform public health policy and intervention strategies for breaking the cycle of poor mental health and socioeconomic disadvantage.","11841079; ","SCORZA, PAMELA LORRAINE;","SARAMPOTE, CHRISTOPHER S","04/22/2019","03/31/2023","Address; Adult; Adverse event; attentional control; base; Behavior; behavior observation; Behavioral; Behavioral Mechanisms; biobank; biobehavior; Biological; Biological Assay; Blood specimen; Budgets; career; caregiving; Cessation of life; Child; Child Health; Child Mental Health; Child Rearing; Childhood; cohort; Cohort Studies; Communities; Data; Data Collection; Data Set; Development; Disadvantaged; disadvantaged population; Disease; DNA; DNA Methylation; early childhood; early life stress; epigenetic marker; Epigenetic Process; epigenome; Event; experience; Exposure to; Future; Generations; Genes; genome-wide; genome-wide analysis; Goals; hands-on learning; Health; Health Policy; Human; Individual; Infant; innovation; intergenerational; Intervention; Investigation; Knowledge; Life; Longitudinal Studies; maternal caregiving; Measures; Mental disorders; Mental Health; Mentored Research Scientist Development Award; Mentors; Mentorship; Methylation; Mother-Child Relations; Mothers; National Institute of Mental Health; New York; Newborn Infant; next generation; offspring; Outcome; Parents; Participant; Pathway interactions; Perinatal; peripheral blood; physical abuse; Population; population based; Population Study; Poverty; Pregnancy; Pregnant Women; Prevention Research; Process; programs; prospective; psychobiology; psychologic; Public Health; Puerto Rican; Puerto Rico; Reaction; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; response; Risk; Risk Factors; Sample Size; Sampling; Sexual abuse; Signal Transduction; socioeconomic disadvantage; Stress; stressor; Training; translational approach; transmission process; Umbilical Cord Blood; United Kingdom; United States National Institutes of Health; Vulnerable Populations; Woman; Work; Youth; ","Mothers' childhoods and the intergenerational transmission of mental health risk in the context of adversity","117443","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","A1","01","167116","12865","179981",""
"9749146","R01","EB","5","N","04/22/2019","04/01/2019","03/31/2020","286","R01EB025025","SCHOOLS OF MEDICINE","RFA-EB-16-909","5R01EB025025-03","NIGMS:333071\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","STANFORD","UNITED STATES","PEDIATRICS","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943041222","We have developed a combined software-hardware solution built on top of Google Glass that enables real lime expression recognition and field-of-view eye tracking to capture social interaction data and give guiding social cues to an individual with Autism. This project will test and optimize the potential of this tool to provide continuous and naturalized behavioral therapy to children with autism from their homes.","8231445; ","WALL, DENNIS PAUL;","LASH, TIFFANI BAILEY","07/05/2017","03/31/2020","adaptive learning; Address; Advertising; Affective; Age; Android; Artificial Intelligence; Augmented Reality; Autistic Disorder; Awareness; base; Behavior; Behavior Therapy; Behavioral; Benchmarking; Big Data; Biomedical Engineering; care delivery; Caregivers; Caring; Child; Child Development; Classification; Clinical; Complex; Computer software; Cues; Data; Databases; deep learning; design; Emotions; empowered; Environment; experimental study; Eye; Face; Facial Expression; Facial Expression Recognition; Family; Family member; Feedback; Future; Glass; Goals; Health; Healthcare; Healthcare Systems; Home environment; Human; human-in-the-loop; Image; Imagery; improved; Individual; Internet; Intervention; Label; Learning; Lighting; Limes; Machine Learning; Methods; mobile computing; Modeling; novel; Outcome; Parents; Participant; personalized health care; Persons; Precision Health; Procedures; prototype; Records; Recovery; response; Running; Self-Direction; Series; smartphone Application; social; social engagement; Social Interaction; social learning; Social Marketing; social skills; System; Testing; Therapeutic; Time; tool; Training; Update; Validation; Variant; Work; ","QuBBD: Wearable artificial intelligence for bid data-driven healthcare in child development  ","025025","ZRG1","Special Emphasis Panel ","","","03","212147","120924","333071",""
"9763031","R13","CA","1","N","04/22/2019","04/22/2019","03/31/2020","394","R13CA239610","","PA-18-648","1R13CA239610-01","NCI:15000\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Project Narrative The 17th Biennial International Photodynamic Association (IPA) World Congress is a scientific meeting organized by the IPA. The Congress brings together scientists and clinicians researching Photodynamic Therapy and Photodiagnosis in order to advance this field of medicine.","1877772; ","HASAN, TAYYABA ;","TATA, DARAYASH B","04/22/2019","03/31/2020","Address; Area; base; Basic Science; biophysical chemistry; Boston; brain tumor resection; Breathing; Capital; career; Cells; Chemistry; Clinic; Clinical; Clinical Research; Collaborations; Communities; Congresses; Country; cytotoxic; cytotoxicity; Data Analyses; Development; Devices; Diagnosis; Disabled Persons; Doctor of Philosophy; Drug Delivery Systems; Educational workshop; Engineering; Event; Excision; experience; Exposure to; Financial Support; Fluorescence; Funding; General Hospitals; Germany; Health; health care disparity; Healthcare; Human; human disease; Human Resources; human subject; Image; image guided; imaging agent; Individual; Industrialization; Industry; Institutes; interest; International; Knowledge; lectures; Light; Lighting; Massachusetts; medical schools; Medicine; meetings; member; Minority Groups; Mission; Modality; Modification; Monitor; multidisciplinary; Nanotechnology; Nature; new technology; Operative Surgical Procedures; optical imaging; Optics; Oral; Participant; Pharmaceutical Preparations; Pharmacology; Photosensitization; Photosensitizing Agents; Physiology; Play; Postdoctoral Fellow; posters; Principal Investigator; professor; programs; Public Health; PUVA Photochemotherapy; Radio; Request for Proposals; Research; Research Personnel; Role; Schools; Science; Scientist; Series; spatiotemporal; Stem cells; Students; symposium; Technology; Technology Transfer; theranostics; Time; Tissues; Translating; Translational Research; Travel; Underrepresented Minority; United States National Institutes of Health; Woman; Work; ","17th Biennial International Photodynamic Association World Congress","239610","ZCA1","Special Emphasis Panel ","","","01","15000","","15000",""
"9769447","G11","TW","1","N","04/22/2019","04/22/2019","03/31/2020","989","G11TW010948","SCHOOLS OF MEDICINE","PAR-16-280","1G11TW010948-01A1","FIC:101360\","OTHER RESEARCH-RELATED","2019","FOGARTY INTERNATIONAL CENTER","","CHARLOTTESVILLE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","05","065391526","US","1526402","UNIVERSITY OF VIRGINIA","VA","229044195","Project Narrative Mbarara University of Science and Technology (MUST), located in rural Uganda, is home to passionate researchers who are poised to take the lead on research projects and scientific advancements throughout the region which will address the HIV/AIDS and related co-infection and infectious diseases that are so prevalent in the communities they serve. In order to make this important and necessary advancement however, the researchers must be fully supported by highly trained and knowledgeable research managers and administrators. This proposal presents a comprehensive and detailed training and mentoring program that is in direct response to the ?Research administration and management? function supported by this funding opportunity, which will ensure a fully integrated advancement over both the short, mid and long term by MUST's own research staff and enterprise.","11231164; 15181467 (contact); ","BAJUNIRWE, FRANCIS ; OLMSTED, ELIZABETH  (contact);","BANSAL, GEETHA PARTHASARATHY","04/22/2019","03/31/2022","Academia; Accountability; Accounting; Acquired Immunodeficiency Syndrome; Address; Administrator; Africa; AIDS/HIV problem; Area; Award; Basic Science; Budgets; certificate program; Cessation of life; Clinical Research; co-infection; Collaborations; Communicable Diseases; Communities; Computer software; Country; Data Analyses; design; Development; Disease; Educational Curriculum; Ensure; Environment; Equipment; Funding Opportunities; Future; global health; Goals; Grant; high risk; HIV; Home environment; Human; Human Resources; implementation research; Incidence; Infection; infrastructure development; innovation; Institution; Instruction; International; Knowledge; Knowledge acquisition; Lead; Leadership; medical schools; meetings; Mentors; Modernization; Outcome; patient population; Play; Policies; Prevalence; Process; Professional Organizations; programs; Publications; Reporting; Research; research and development; Research Infrastructure; Research Personnel; Research Priority; Research Project Grants; Research Training; response; Rural; Science; science teacher; Seasons; Self-Direction; Series; Site; skill acquisition; skills; Standardization; Strategic Planning; Structure; suburb; success; symposium; System; Technology; Time; Training; Training Activity; Training Programs; trend; Uganda; United States National Institutes of Health; Universities; Virginia; Work; ","Advancing HIV research at Mbarara University of Science and Technology (MUST) through a research administration training program with the University of Virginia","010948","ZRG1","Special Emphasis Panel ","","A1","01","96901","4459","101360",""
"9777210","R41","AI","1","N","04/22/2019","04/22/2019","03/31/2020","855","R41AI145611","","PA-18-575","1R41AI145611-01","NIAID:230244\","SBIR-STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","COLUMBIA","UNITED STATES","","04","080551860","US","10045779","ZENVAX, LLC","MO","652110001","Project Narrative: This STTR project aims to use the development of a Q fever mimotope vaccine as the model system to prove the concept that the mimotope vaccine technology can be utilized as a broad platform against other microbial pathogens.","9501573; ","ZHANG, GUOQUAN ;","ZOU, LANLING","04/22/2019","03/31/2020","Acute; Adjuvant; Adverse effects; Aerosols; Antigens; Australia; Autoantibodies; Bacteriology; base; Biological Models; Biological Warfare; biosecurity; Biotechnology; bioterrorism/chemical warfare; Businesses; Cells; Chronic; Chronic Disease; Clinical; Communicable Diseases; Coxiella burnetii; Development; Diagnosis; Disease; Disease Outbreaks; Dose; Environmental Risk Factor; Epitopes; Erythema; experience; Exposure to; flu; Formalin; Goals; Gram-Negative Bacteria; Headache; Health; high risk; Home environment; Human; Hypersensitivity skin testing; Immunity; Immunization; immunogenicity; Immunoglobulin G; Immunologic Memory; Inactivated Vaccines; Individual; Infection; Infectious Diseases Research; Keyhole Limpet Hemocyanin; Laboratory Animals; Laboratory Research; Lipopolysaccharides; Membrane; Microbiology; Middle East; Missouri; Monitor; National Institute of Allergy and Infectious Disease; Nature; Netherlands; novel vaccines; Organism; pathogen; pathogenic bacteria; pathogenic microbe; Pathogenicity; peptidomimetics; Phase; Prevention; protective efficacy; Public Health; Publishing; Q Fever; Reporting; Research; Research Peer Review; Resistance; response; Route; Safety; Serological; seropositive; Soldier; Surface; Swelling; Symptoms; T-Lymphocyte; Technology; Technology Transfer; Testing; The science of Mycology; Translating; Ultraviolet Rays; United States National Institutes of Health; Universities; Vaccination; vaccine candidate; Vaccines; Whole Cell Vaccine; Work; Zoonoses; ","Use of mimotope vaccine technology to develop vaccines against bacterial pathogens","145611","ZRG1","Special Emphasis Panel ","","","01","","","230244",""
"9777687","R44","DK","1","N","04/22/2019","04/01/2019","03/31/2020","847","R44DK120338","","PAR-18-108","1R44DK120338-01A1","NIDDK:281612\","SBIR-STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BLACKSBURG","UNITED STATES","","09","033199995","US","10030530","BIOTHERAPEUTICS, INC.","VA","240606370","Abscisic acid (ABA) has demonstrated outstanding efficacy in improving glycemic control, but even though its concentration in some fruits is high, the amount of ABA available in the normal diet alone fails to provide an effective control of blood sugar levels. Given that 34% of adults in the U.S. have metabolic syndrome, obesity, prediabetes, or diabetes; and they also have low levels of ABA in metabolic pools, an ABA-containing medical food developed under this SBIR could address the overlying health problems of over 100 million US consumers with a market exceeding $58B annually by 2018 and could also disrupt the $9B medical foods and 15B functional water markets.","11176978; ","HONTECILLAS, RAQUEL ;","LI, YAN","04/01/2019","03/31/2020","Abscisic Acid; Address; Adipocytes; Adult; Adverse effects; American; Animals; Antidiabetic Drugs; base; Biological Response Modifier Therapy; Biopsy; Blood; Blood Glucose; blood glucose regulation; Cells; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinical Research; commercial application; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Consumption; Cross-Over Trials; Data; Development; Diabetes Mellitus; diabetic; Diabetic mouse; Diet; Dose; Fatty acid glycerol esters; feeding; Fruit; fruits and vegetables; Glucose; Glucose Clamp; glucose disposal; Glucose Intolerance; glucose metabolism; glucose tolerance; glucose uptake; GLUT4 gene; glycemic control; Glycogen; Goals; Health; Human; Human body; improved; Inflammation; innovation; Insulin; Insulin Resistance; insulin sensitivity; insulin signaling; Intake; Intellectual Property; knockout animal; Legal patent; Life Style; Medical; medical food; Metabolic; Metabolic syndrome; Methods; Mus; Muscle; Muscle Cells; Muscle Fibers; Myoblasts; Non-Insulin-Dependent Diabetes Mellitus; nutrition; Obesity; Oral; Outcome; oxidation; Patients; Persons; Phase; placebo controlled study; Placebos; Plasma; Population; Prediabetes syndrome; Production; Randomized; Rattus; Recommendation; research and development; Role; Signal Transduction; Site; Skeletal Muscle; Small Business Innovation Research Grant; Small Interfering RNA; Specificity; Structure of beta Cell of islet; Supplementation; Symptoms; Toxicology; translational study; Translations; uptake; Virginia; Water; ","Effects of Abscisic Acid on Insulin Sensitivity","120338","ZDK1","Special Emphasis Panel ","","A1","01","","","281612",""
"9789659","I01","VA","5","N","04/25/2019","04/01/2019","12/31/2019","999","I01HX001134","","RFA-HX-12-018","5I01HX001134-05","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","SALT LAKE CITY","UNITED STATES","","02","009094756","US","481089","VA SALT LAKE CITY HEALTHCARE SYSTEM","UT","841480001","While the VA has been successful in reducing methicillin-resistant Staphylococcus aureus  (MRSA) infection rates, these infections remain a significant problem for hospitalized Veterans.  Efforts to identify the most effective and cost-efficient control strategies must continue. The  challenge is to understand which interventions have the greatest impact, alone and in  combination, and how best to implement them in a particular healthcare environment. In  addition, the benefit of targeting long-term care facilities such as VA Community Living Centers  in MRSA prevention and the importance of physician and nurse team behaviors in influencing  various types of control efforts are unknown. We expect the results of this project to have great  impact in improving VA quality of care, both for identifying targets for current intervention and for  informing future policy modifications.","9589867; 7607573 (contact); ","LEYKUM, LUCI ; RUBIN, MICHAEL A. (contact);","","04/01/2015","12/31/2019","Acute; Affect; Attention; base; Behavior; behavior measurement; Blood Circulation; Caring; Clinical; Clinical Data; Cluster randomized trial; Communicable Diseases; Communities; community living; comparative effectiveness; compare effectiveness; Computer Simulation; cost; cost effective; cost effectiveness; Cost effectiveness research; cost efficient; Cost-Benefit Analysis; Custom; Data; Databases; Detection; Disease Outbreaks; Economics; Effectiveness; effectiveness research; Environment; Epidemiologic Methods; Epidemiology; Ethnography; experience; experimental study; Frequencies; Funding; Future; Goals; graphical user interface; Hand; Health care facility; Health Personnel; Healthcare; high risk population; Hospitalization; Hospitals; Hygiene; improved; Incidence; Individual; Infection; Infection Control; Infection prevention; insight; Intervention; Intranet; Investigation; Lead; Literature; Long-Term Care; methicillin resistant Staphylococcus aureus; Methods; microbial; Modeling; models and simulation; Modification; Nature; Online Systems; Organism; Outcome; pathogen; Patient-Focused Outcomes; Patients; Patients' Rooms; Physicians; Policies; Prevalence; prevent; Prevention; programs; Provider; Published Comment; Quality of Care; Research; Risk Factors; Series; Services; simulation; Staphylococcus aureus infection; systematic review; Team Nursing; Time; tool; transmission process; uptake; Veterans; virtual; Visit; Work; ","Preventing MRSA infections: a virtual comparative effectiveness model","001134","HCR1","HCR 1 - CREATE PTSD ","","","05","","","",""
"9830844","R01","CA","7","N","04/23/2019","04/23/2019","12/31/2019","394","R01CA214072","SCHOOLS OF MEDICINE","PA-18-590","7R01CA214072-03","NCI:156163\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","FARMINGTON","UNITED STATES","INTERNAL MEDICINE/MEDICINE","05","022254226","US","1506603","UNIVERSITY OF CONNECTICUT SCH OF MED/DNT","CT","060305335","Narrative: The objective of this project is to develop a minimally-instrumented, point of care (POC) molecular diagnostic system, and build research capacity in order to create a solid infrastructure for the implementation of cervical cancer screening in laboratory conditions as well as on the field in China. The results obtained using our POC diagnostic system will be recorded, analyzed and report using a mobile phone and compared against the results obtained using standard PCR-based diagnostic methods.","10350150; ","LIU, CHANGCHUN ;","PATRIOTIS, CHRISTOS F","01/19/2017","12/31/2021","Academy; Acetic Acids; Acquired Immunodeficiency Syndrome; Area; base; Biological Assay; Car Phone; Cellular Phone; Cervical Cancer Screening; Cessation of life; chemical reaction; Chemicals; China; Chinese People; Clinical; clinical application; Collaborations; comparative; Complex; cost; County; design; Detection; detector; Development; Devices; Diagnostic; Diagnostic Procedure; DNA; Epidemic; Epidemiology; Evaluation; experience; FDA approved; Feedback; field study; General Population; Genotype; health care quality; Health Personnel; Heating; High Prevalence; high risk; HIV; HIV Seropositivity; Hospitals; HPV-High Risk; Human Characteristics; Human papilloma virus infection; Human Papillomavirus; Human Resources; improved; improved outcome; Individual; Infrastructure; innovation; Institutes; instrument; International; Laboratories; low and middle-income countries; Malignant neoplasm of cervix uteri; Malignant Neoplasms; Medical; melting; Methods; Molecular Diagnosis; molecular diagnostics; Morbidity - disease rate; mortality; multidisciplinary; Nucleic Acid Hybridization; operation; Optics; pandemic disease; Pennsylvania; Performance; phase change; point of care; point-of-care diagnostics; Point-of-Care Systems; portability; Province; rapid detection; Reaction; Reporting; Reproducibility; Research; Research Personnel; Resources; Rural; Sampling; Science; Sensitivity and Specificity; Site; Solid; stem; System; Technology; Temperature; Testing; Time; tool; Training; Translating; Treatment outcome; Universities; Vagina; Validation; viral detection; Visual; Woman; Women's Health; ","Point of Care Diagnostics of HPV-Associated Cervical Cancer in HIV Epidemic Areas in China","214072","ZRG1","Special Emphasis Panel ","","","03","95985","60178","156163",""
"9857901","R01","DA","3","N","04/25/2019","04/01/2019","03/31/2020","279","R01DA046527","","PA-18-591","3R01DA046527-02S1","NIDA:177998\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","BOSTON","UNITED STATES","","07","005492160","US","3617301","BOSTON MEDICAL CENTER","MA","021182908","PROJECT NARRATIVE The Researching Effective Strategies to Prevent Opioid Death (RESPOND) project will develop a population simulation model of opioid use disorder (OUD) in a state and use it to inform state-level innovations for low- barrier access to medications for opioid use disorder.","8727407; ","LINAS, BENJAMIN P.;","DUFFY, SARAH Q","06/01/2018","03/31/2023","addiction; Age; American; care delivery; Caring; Cessation of life; Clinical Research; cost; cost effective; Cost Sharing; Costs and Benefits; Coupled; Criminal Justice; Data; Data Set; Data Sources; Economic Factors; Epidemic; Epidemiologic Factors; Evidence based treatment; Exercise; experience; FDA approved; fight against; Funding; Goals; Gold; Health Care Costs; health economics; Health Policy; illicit opioid; improved; innovation; Insurance; Insurance Coverage; Intervention; Knowledge; Life Expectancy; Literature; Massachusetts; Medical; Medicine; Methadone; Modeling; models and simulation; Morals; mortality; Naltrexone; Operating System; Opioid; opioid mortality; opioid overdose; opioid use; opioid use disorder; Outcome; Overdose; Patients; Pharmaceutical Preparations; Policies; Policy Maker; Population; population health; Positioning Attribute; premature; prescription opioid; prevent; prior authorization; Process; programs; Public Health; public health emergency; Records; Registries; Regulation; Research; Research Personnel; Resources; simulation; skills; Social Functioning; Societies; Source; standard of care; stem; Suboxone; Substance Use Disorder; symposium; Symptoms; synergism; System; Thinking; Time; Translating; Work; ","Researching Effective Strategies to Prevent Opioid Death (RESPOND)","046527","ZRG1","Special Emphasis Panel ","","S1","02","99999","77999","177998",""
"9872279","KL2","TR","3","N","04/23/2019","04/23/2019","02/29/2020","350","KL2TR002492","SCHOOLS OF MEDICINE","PAR-15-304","3KL2TR002492-02S1","NCCAM:143732\","OTHER RESEARCH-RELATED","2019","NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES","","MINNEAPOLIS","UNITED STATES","PEDIATRICS","05","555917996","US","1450402","UNIVERSITY OF MINNESOTA","MN","554552070","","1901035; ","INGBAR, DAVID H;","DAVIS NAGEL, JOAN","03/30/2018","02/28/2023","Active Learning; Applications Grants; Appointment; Award; base; Biomedical Engineering; career; career development; Cities; Clinical Research; Clinical Sciences; college; Communication; Communities; Competence; County; Dentistry; design; Development; Development Plans; education research; Ensure; Environment; Ethics; experience; Faculty; Faculty Recruitment; Fostering; Foundations; Funding; Future; Generations; Goals; Grant; Health; Hospitals; improved; Individual; Informatics; innovation; Institutes; Institution; Investigation; K-Series Research Career Programs; Leadership; Medical center; medical schools; Medicine; Mentors; Minnesota; multidisciplinary; NCI Scholars Program; Nursery Schools; Patient Care; Pharmacy facility; Positioning Attribute; Principal Investigator; Program Development; programs; Public Health; Public Health Nursing; Research; Research Institute; Research Personnel; responsible research conduct; Schools; Science; Series; skills; success; Talents; Time; Training; Training Programs; Translational Research; translational research program; translational scientist; Twin Multiple Birth; undergraduate student; United States National Institutes of Health; Universities; Veterinary Medicine; Visit; Wages; ","Institutional Career Development Core","002492","ZTR1","Special Emphasis Panel ","","S1","02","133270","10462","143732",""
"9894990","U01","HG","3","N","04/25/2019","04/25/2019","03/31/2020","172","U01HG008657","","RFA-HG-14-025","3U01HG008657-05S2","NHGRI:707923\","Non-SBIR/STTR RPGs","2019","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","OAKLAND","UNITED STATES","","13","150829349","US","3497005","KAISER FOUNDATION RESEARCH INSTITUTE","CA","946123466","PUBLIC HEALTH RELEVANCE: This eMERGE III proposal builds on past discoveries and research designed to translate genomic advances into clinical care involving clinicians, patients and families. This phase focuses on traits associated with preventable health concerns: colon cancer, triglycerides, and immunity. We address optimal methods to share information across families and whether other information found by genomic tests impact the care, health, and medical costs of individuals.","1873248; 1858175 (contact); ","JARVIK, GAIL PAIRITZ; LARSON, ERIC B (contact);","ROWLEY, ROBB KENNETH","09/01/2015","03/31/2020","Address; age related; Algorithms; Amendment; American; Asians; base; Blood; Cardiovascular Diseases; care costs; Caring; Clinical; clinical care; clinical decision support; clinical practice; Collaborations; Colon Carcinoma; Colorectal Cancer; Communication; Community Practice; Complex; Computerized Medical Record; cost effectiveness; Coupled; Data; design; Development; Digital Libraries; Disease; Disease Resistance; economic cost; economic impact; economic outcome; Economics; Education; Effectiveness; Electronic Medical Records and Genomics Network; Ensure; Evaluation; Family; General Population; Genes; Genetic; genetic association; Genetic Diseases; genetic variant; genome wide association study; genomic data; Genomic medicine; Genomics; Goals; Health; Health Care Costs; Health system; Herpes zoster disease; Immunity; improved; Incidental Findings; Individual; innovation; Integrated Delivery Systems; interest; Intuition; Laboratories; Leadership; Link; Long QT Syndrome; Malignant Neoplasms; Medical; Medical Care Costs; Medical Genetics; medical schools; medical specialties; Methods; Mission; Modeling; Morbidity - disease rate; mortality; National Human Genome Research Institute; Natural Language Processing; neutrophil; novel; online resource; Other Genetics; outreach; Participant; Pathogenicity; Patient Care; patient portal; Patients; Penetrance; Pharmacogenetics; Phase; Phenotype; Physicians; Policy Developments; polyposis; Population; practice setting; Predisposition; prevent; Preventive screening; Primary Health Care; Process; Provider; public health relevance; Randomized Controlled Trials; rare variant; Reporting; Research Design; Resources; Risk; screening; Site; Social Impacts; Technology; Testing; tool; trait; Translating; Triglycerides; Universities; Variant; Washington; Work; ","The Electronic Medical Records and Genomics (eMERGE) Network, Phase III","008657","ZHG1","Special Emphasis Panel ","","S2","05","568504","139419","707923",""
"9901696","U01","NS","3","N","04/24/2019","04/01/2019","11/30/2019","853","U01NS093334","SCHOOLS OF MEDICINE","PA-18-591","3U01NS093334-04S1","NINDS:589149\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","BOSTON","UNITED STATES","NEUROLOGY","07","604483045","US","894901","BOSTON UNIVERSITY MEDICAL CAMPUS","MA","021182841","Project Narrative Chronic Traumatic Encephalopathy (CTE) is a degenerative disease of the brain caused, in part, by repeated concussive and/or subconcussive brain trauma, such as that experienced by football players and other contact-sport athletes, and by millions of athletes spanning from youth to professional levels who participate in contact sports. It is critically important to develop methods to diagnose CTE during life so that interventions can be developed for treatment and prevention, and so additional risk factors for the disease can be determined. This study will be the first multicenter study to examine possible tools for CTE diagnosis and to validate diagnostic criteria for the clinical diagnosis of this potentially preventable disease.","1872647; 2092025; 1893384; 8404019 (contact); ","CUMMINGS, JEFFREY L.; REIMAN, ERIC MICHAEL; SHENTON, MARTHA E.; STERN, ROBERT A (contact);","BELLGOWAN, PATRICK S F","04/01/2019","11/30/2022","Address; Age; Alzheimer's Disease; Amygdaloid structure; Amyloid; Astrocytes; Attention; Award; Behavior; Behavioral; Biological Markers; Boxing; Brain; brain abnormalities; Brain Chemistry; Brain Concussion; Brain Diseases; Case Study; chronic traumatic encephalopathy; Clinical; clinical Diagnosis; clinical diagnostics; Cognitive; college; Consensus; Consensus Workshop; Control Groups; Corpus Callosum; Country; Data; Databases; Degenerative Disorder; Dementia; Deposition; design; Detection; Diagnosis; Diagnostic; diagnostic accuracy; Diffusion Magnetic Resonance Imaging; Disease; effective intervention; Epilepsy; experience; Exposure to; follow-up; Frequencies; Functional Magnetic Resonance Imaging; Genetic; Genetic Polymorphism; Gold; Grant; Growth; Head; head impact; high risk; high school; Image; Impairment; in vivo; Individual; infancy; insight; Intervention; Life; Liquid substance; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Manufactured football; Measures; men; Methods; Military Personnel; Modeling; Moods; Motor; Multicenter Studies; multidisciplinary; Nerve Degeneration; Neurocognitive; Neurodegenerative Disorders; neuroimaging; Neurologic; Neurons; neuropathology; novel; Pattern; physical abuse; Plasma; Play; Positron-Emission Tomography; Prevention; Preventive Intervention; Process; Proxy; Publishing; Recording of previous events; Reporting; Research Personnel; Rest; Risk; Risk Factors; Science; Septum Pellucidum; service member; sharing data; Signs and Symptoms; Sports; Subgroup; symposium; Symptoms; Syndrome; tau Proteins; tau-1; Tauopathies; Testing; Thinness; tool; Tracer; Trauma; Traumatic Brain Injury; uptake; Validation; Validity and Reliability; Variant; white matter; Writing; Youth; ","Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk Factors","093334","","","","S1","04","436407","152742","589149",""
"9903548","P30","DK","3","N","04/24/2019","04/01/2019","03/31/2020","847","P30DK056350","SCHOOLS OF PUBLIC HEALTH","RFA-DK-14-002","3P30DK056350-19S1","OD:155294\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","CHAPEL HILL","UNITED STATES","NUTRITION","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","PUBLIC HEALTH RELEVANCE    The University of North Carolina Nutrition Obesity Research Center (UNC NORC) focuses on Trans- Disciplinary Nutrition Research: From Molecules to Public Health. We propose an Administrative Core and five Scientific Core Facilities: 'Diet and Physical Activity in Human Populations (DPAC),' 'Nutrition Communication for Health Applications and Interventions (CHAI),' 'Metabolic Molecular Phenotyping (MMP)', 'Animal Metabolism Phenotyping (AMP) and Nutrigenetics (NGx)","1875798; 7353138 (contact); ","MAYER-DAVIS, ELIZABETH J; ZEISEL, STEVEN H (contact);","EVANS, MARY","09/30/1999","03/31/2021","Address; Affect; analytical tool; Animals; Assessment tool; Award; base; Basic Science; Behavior; behavior observation; behavioral study; Biochemical; Biological Markers; Body Composition; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical; Clinical Research; Collaborations; Communities; community based participatory research; Complex; Core Facility; cost effective; Data Analyses; Development; Diet; Discipline; Doctor of Philosophy; Effectiveness; Epidemiology; Equipment; Fostering; Funding; General Population; genetic makeup; Genetic Variation; Goals; Grant; Health; health application; Health Communication; Health Professional; Health Status; Human; improved; Individual; Infrastructure; Interdisciplinary Study; Intervention; Laboratories; Laboratory Finding; Leadership; member; Metabolic; Metabolic Diseases; Metabolic Pathway; metabolic phenotype; Metabolism; Methods; Molecular; molecular phenotype; mouse model; multidisciplinary; National Institute of Diabetes and Digestive and Kidney Diseases; North Carolina; novel strategies; nutrition; nutrition education; nutrition related genetics; Nutritional Study; Obesity; Peer Review; Phenotype; Physical activity; Physicians; Population; population based; Population Research; Population Study; Productivity; programs; Public Health; public health relevance; Publications; Research; Research Personnel; Resources; Risk; Scientist; Seeds; Services; Social Sciences; success; Time; tool; Training Programs; Translating; United States National Institutes of Health; Universities; Variant; ","Nutrition Obesity Research Center (NORC)","056350","ZDK1","Special Emphasis Panel ","","S1","19","99867","55427","155294",""
"9903551","P30","DK","3","N","04/24/2019","04/01/2019","03/31/2020","","P30DK056350","","RFA-DK-14-002","3P30DK056350-19S1","NIDDK:155294\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","CHAPEL HILL","UNITED STATES","","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","","1881976; ","BECK, MELINDA A.;","EVANS, MARY","","","base; Biochemical Markers; Biological Assay; Biological Markers; biomarker selection; Carbon; Cell Separation; Cells; Client; Clinical Sciences; Consultations; cost effective; cytokine; Cytometry; Data; Data Analyses; digital; Disease; Documentation; Enzyme-Linked Immunosorbent Assay; epidemiology study; Equipment; extracellular; Fatty Acids; flexibility; Flow Cytometry; Fluorescence Microscopy; Funding; Gel; Genus Hippocampus; Glycolysis; Goals; Health Services Accessibility; Hour; Human Resources; Institutes; Intervention Studies; Measures; member; Metabolic; Methods; Mitochondria; Molecular; Molecular Biology Techniques; molecular marker; molecular phenotype; North Carolina; nutrition; Nutritional; Nutritional Biochemistry; Nutritional status; Obesity; Phospholipids; Postdoctoral Fellow; Price; Quality Control; Reader; Research; Research Personnel; Running; Sampling; satisfaction; Savings; Scientist; Services; Shipping; Site; Sorting - Cell Movement; student training; Surveys; System; Techniques; Training; Translational Research; Universities; Variant; ","Metabolic Molecular Phenotyping Core","056350","ZDK1","Special Emphasis Panel ","6080","S1","19","99867","55427","","155294"
"9572666","P30","EY","2","N","04/25/2019","04/01/2019","03/31/2020","","P30EY008098","","PAR-17-322","2P30EY008098-31","NEI:27377\","RESEARCH CENTERS","2019","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","","9403772; ","GROSS, JEFFREY ;","","","","Collaborations; Communication; Core Grant; Effectiveness; Ensure; Faculty; Funding; Future; Goals; Research Personnel; Resources; Services; Strategic Planning; Vision research; ","Administrative Core","008098","ZEY1","Special Emphasis Panel ","5954","","31","17493","9884","","27377"
"9623361","R01","HL","5","N","04/25/2019","04/01/2019","03/31/2020","837","R01HL139689","SCHOOLS OF MEDICINE","PA-16-160","5R01HL139689-02","NHLBI:566573\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","SALT LAKE CITY","UNITED STATES","NEUROLOGY","02","009095365","US","514002","UNIVERSITY OF UTAH","UT","841128930","Nearly one third of the adults in the United States are suffering from hypertension and only half of them can attain the optimal blood pressure control. The current proposal has the potential to advance our understanding of the fundamental mechanism of hypertension and also to identify a novel target for antihypertensive therapies.","7367571; ","YANG, TIANXIN ;","OH, YOUNGSUK","06/01/2018","03/31/2022","Adenylate Cyclase; Adult; Aldosterone; Antihypertensive Agents; Attenuated; beta catenin; Binding; Biological Markers; Blood Pressure; blood pressure regulation; Cells; Collecting Cell; CREB1 gene; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease; Distal; DOCA; Duct (organ) structure; Ductal Epithelial Cell; Embryonic Development; epithelial Na+ channel; Extracellular Domain; Gene Targeting; Genetic Transcription; Hypertension; In Vitro; Inactive Renin; inhibitor/antagonist; Injury; insight; Intercalated Cell; Kidney; Mammals; Mediating; Mineralocorticoids; Nephrons; novel; novel therapeutics; paracrine; Pathogenesis; Pathway interactions; Process; receptor; receptor binding; Regulation; Renal function; Renin; Role; salt sensitive hypertension; Signal Transduction; Sodium Chloride; Techniques; Testing; United States; Vertebrates; ","Role of (pro)renin receptor in aldosterone signaling in the kidney","139689","HM","Hypertension and Microcirculation Study Section ","","","02","371523","195050","566573",""
"9637401","R00","HD","5","N","04/26/2019","02/01/2019","01/31/2020","865","R00HD082340","","PA-14-042","5R00HD082340-05","NICHD:233891\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","BOSTON","UNITED STATES","","07","076593722","US","1504801","BOSTON CHILDREN'S HOSPITAL","MA","021155724","PUBLIC HEALTH RELEVANCE: Transgender youth may be at greater risk than non-transgender youth for negative health outcomes, such as substance use, self-harm, and depression, due in part to stressors related to the family environment. This research will increase knowledge about the longitudinal effects of the family environment on health outcomes among transgender youth and the development of innovative interventions that can ultimately improve the health and well-being of transgender youth and families.","11817394; ","KATZ-WISE, SABRA L.;","BURES, REGINA M","02/25/2017","01/31/2020","absorption; Address; Affect; Age; Alcohol or Other Drugs use; Anxiety; Attitude; Award; base; Behavior; biological adaptation to stress; Birth; Caring; Clinic; Cognitive; community based participatory research; community center; cultural values; Data; Development; digital; Discrimination; Environment; experience; Family; Family member; family support; Fostering; Future; Gender; Gender Identity; gender minority; Goals; Group Homes; Health; Health behavior change; Health Promotion; Homelessness; Housing; improved; Individual; innovation; Institute of Medicine (U.S.); Intervention; Intervention Studies; Interview; Knowledge; Lead; Lesbian, Gay, Bisexual and Transgender; Link; Mental Depression; Mentors; Methods; Minority; Modeling; Multimedia; negative affect; New England; Outcome; Parents; Participant; Pathway interactions; Personal Satisfaction; Persuasive Communication; Phase; Play; Population; Prejudice; Process; Provider; psychologic; public health relevance; Qualitative Methods; recruit; Research; Risk; Self Efficacy; Self-Injurious Behavior; sex; sex risk; sexual minority; Shelter facility; Siblings; skills; social; Social Network; social stigma; Social support; Source; Stigmatization; Stress; stressor; Suicide; support network; Surveys; System; Systems Theory; Target Populations; Testing; theories; therapy development; Time; Training; transgender; Transportation; United States National Institutes of Health; Visual; Work; Youth; ","The Family Environment, Social Support, and Health in Transgender Youth","082340","NSS","Special Emphasis Panel ","","","05","135179","104088","233891",""
"9638291","U10","CA","2","N","04/26/2019","03/01/2019","02/29/2020","","U10CA180888","","RFA-CA-17-056","2U10CA180888-06","NCI:3930712\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","6765159; ","BLANKE, CHARLES D.;","","","","adjudicate; Adolescent and Young Adult; Clinical Trials; Collaborations; Collection; Communication; Contracts; Data; data management; Development; Ensure; financial conflict of interest; Funding; improved; Individual; Infrastructure; Legal; Link; meetings; member; Mission; Monitor; Occupational activity of managing finances; operation; Organizational Policy; organizational structure; patient safety; Policies; Population; Procedures; Process; Protocols documentation; Publications; quality assurance; Records; Reporting; Research; Safety; Serious Adverse Event; Southwest Oncology Group; Specimen; Speed; Structure; Tissues; Training Programs; Translational trial; Work; ","SWOG Network Group Operations Center of the NCTN","180888","ZCA1","Special Emphasis Panel ","7180","","06","4949499","499183","","3930712"
"9654798","R01","NS","5","N","04/26/2019","04/01/2019","03/31/2020","853","R01NS090464","SCHOOLS OF MEDICINE","PA-13-302","5R01NS090464-04","NINDS:367369\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","NEW YORK","UNITED STATES","RADIATION-DIAGNOSTIC/ONCOLOGY","12","060217502","US","1514803","WEILL MEDICAL COLL OF CORNELL UNIV","NY","100654805","PUBLIC HEALTH RELEVANCE:  The long term objective of this proposed research is to improve the management of Multiple Sclerosis (MS) patients by advancing our capability of probing the inflammatory and neurodegenerative processes in MS through the development of a noninvasive Quantitative Susceptibility Mapping (QSM) technique in MRI. The time course of MS lesion magnetic susceptibility is a promising biomarker for demyelination in inflammation and iron distribution in both inflammation and neurodegeneration. This research project will focus on establishing the lesion susceptibility time course using a longitudinal prospective study. This research will provide biomedical correlates using immunohistochemical analysis of MS brain specimens, in addition to gadolinium enhancement in longitudinal patient study. Successful outcome of this research will establish that QSM time course of MS is a valuable tool for monitoring the pathogenic process of MS for effective diagnosis and treatment of the more than two million MS patients worldwide.","2090747; ","WANG, YI ;","UTZ, URSULA","04/01/2015","03/31/2021","Accounting; Address; Age; Autopsy; Back; base; Biological Markers; Blood - brain barrier anatomy; Brain; Chronic; Cicatrix; clinical practice; Confusion; Data; data acquisition; Demyelinations; Deposition; Development; Diagnosis; Disease; Financial compensation; Gadolinium; Goals; healing; Image; imaging biomarker; Imaging Techniques; Immunohistochemistry; improved; Inflammation; Inflammatory; interest; Iron; Lesion; Longitudinal prospective study; Longitudinal Studies; Macrophage Activation; Magnetic Resonance Imaging; Magnetism; Maps; Measurement; Measures; Methods; Microglia; Modeling; Monitor; Motion; Multiple Sclerosis; Multiple Sclerosis Lesions; multiple sclerosis patient; Myelin; Nerve Degeneration; Neurologic Deficit; Outcomes Research; Pathogenicity; Pathologic; Patients; Phase; Play; Predisposition; prevent; Process; Property; public health relevance; recruit; Reference Standards; remyelination; Reproducibility; Research; Research Project Grants; Resolution; Retrospective Studies; Role; Scanning; Signal Transduction; Source; spatiotemporal; Specificity; Specimen; Techniques; Testing; Time; Tissue Sample; Tissues; tool; white matter; ","Multiple Sclerosis Lesion Magnetic Susceptibility Activity","090464","MEDI","Medical Imaging Study Section ","","","04","216737","150632","367369",""
"9657087","R01","NS","5","N","04/24/2019","04/01/2019","03/31/2020","853","R01NS092803","SCHOOLS OF MEDICINE","PA-13-302","5R01NS092803-04","NINDS:349327\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","LA JOLLA","UNITED STATES","NEUROSCIENCES","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","PUBLIC HEALTH RELEVANCE: Synucleonopathies such as multiple system atrophy (MSA) affect over 1 million in the US. For this proposal we will investigate how alterations in autophagy-related miRNAs are involved in the pathogenesis of ?-synuclein propagation in MSA and evaluate the value of modulating miRNAs as a novel therapeutic approach for MSA.","10339401; ","DESPLATS, PAULA ALEJANDRA;","SIEBER, BETH-ANNE","04/01/2016","03/31/2021","Affect; Agreement; alpha synuclein; Animal Model; Animals; astrogliosis; Autophagocytosis; base; Basic Science; Behavior; Brain region; brain tissue; Cell Culture Techniques; Cells; cohort; Collaborations; Confocal Microscopy; Development; Disease; Electron Microscopy; Endocytic Vesicle; Endocytosis; Enzyme-Linked Immunosorbent Assay; experimental study; Failure; Gene Targeting; Genes; Goals; Immunoblot Analysis; In Situ Hybridization; in vivo; Infusion procedures; Injections; Intraventricular Infusion; laser capture microdissection; Lead; Lewy Body Dementia; Light; Link; Measures; MicroRNAs; misfolded protein; mixed cell culture; Motor; mouse model; Multiple System Atrophy; Mus; Myelin; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Neurodegenerative Disorders; Neuroglia; Neurons; neuropathology; novel therapeutic intervention; novel therapeutics; Oligodendroglia; osmotic minipump; overexpression; Parkinson Disease; Parkinson's Dementia; Parkinsonian Disorders; Pathogenesis; Pathologic; Pathology; Patients; Platelet-Derived Growth Factor; Primary Cell Cultures; promoter; Protein Sortings; protein transport; Proteins; public health relevance; Recommendation; Regulation; Site; small hairpin RNA; Sorting - Cell Movement; Subfamily lentivirinae; System; Tissues; Transgenic Animals; Transgenic Mice; Transgenic Model; Transgenic Organisms; transmission process; Vesicle; Viral; ","Regulation of the oligodendroglial accumulation of alpha-synuclein in Multiple System Atrophy","092803","CMND","Cellular and Molecular Biology of Neurodegeneration Study Section ","","","04","225372","123955","349327",""
"9665269","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:269642\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1985665; ","HAAS, DAVID W;","","","","Active Learning; Address; African American; American; Anti-HIV Agents; Antidepressive Agents; Behavioral; biobank; Biological; clinical practice; Clinical Research; cohort; Cohort Studies; Collaborations; Communities; cross disciplinary program; CYP2B6 gene; Data; Data Analyses; Data Set; depressive symptoms; Development; Development Plans; diabetic; Differential Diagnosis; Discipline; DNA; Educational Curriculum; efavirenz; emotional distress; Ethnic Origin; European; Fostering; Frequencies; Future; Genetic; Genomic medicine; Genomics; Genotype; Goals; health disparity; Health Professional; help-seeking behavior; Hispanics; human genomics; Infrastructure; innovation; Institutes; Institution; investigator training; Knowledge; learning community; learning strategy; Legal; Link; member; Mentors; Needs Assessment; Patient Self-Report; peer coaching; peer learning; Phenotype; Policies; population health; Precision Health; precision medicine; programs; Publications; Race; Research; Research Methodology; Research Personnel; Resources; Self-Direction; Series; Services; social; Social Behavior; Specimen; Suicide; System; Time; Training; training opportunity; Translating; Translational Research; Work; working group; ","Training and Mentoring Core","010722","ZMD1","Special Emphasis Panel ","8202","","04","253461","56395","","269642"
"9665270","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:203105\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","7647381; ","DENNY, JOSHUA C.;","","","","Address; African American; base; Behavioral; biobank; Biological; Biomedical Research; Childhood; Clinical; Clinical Data; clinical data warehouse; clinical practice; cohort; Collaborations; Collection; Communities; contextual factors; Country; Data; Data Analyses; data management; data mining; Data Set; Data Sources; data warehouse; Databases; Development; Diagnosis; disadvantaged population; Disease; DNA Library; Documentation; Educational Activities; Electronic Health Record; ethnic minority population; Etiology; experience; Food; Genetic; Genetic Diseases; Genetic Research; Genetic study; genomic data; Genomic medicine; Genotype; Goals; Health; health data; health disparity; Hospitals; Housing; Individual; Infrastructure; Institutes; Institution; interest; Language; Latino; Life Style; lifestyle data; Link; literacy; Machine Learning; Medical Genetics; Methods; Minority; mortality; Natural Language Processing; Occupations; Office of Administrative Management; Other Genetics; Outcome; Pain; Patients; Pharmacogenomics; Phenotype; Population; population health; precision medicine; Process; prospective; Public Health; Race; racial minority; Regulation; repository; Research; Research Personnel; Research Support; Resources; Risk Factors; Sample Size; Science; shared decision making; Site; social; Social Environment; Social support; socioeconomic disadvantage; Source; standard care; Taxonomy; Techniques; Terminology; Time; Underrepresented Populations; Universities; Work; ","Bio Repository Core","010722","ZMD1","Special Emphasis Panel ","8203","","04","190916","42479","","203105"
"9665271","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:343080\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","NARRATIVE  Our proposed research aims to better understand why certain population sub-groups persistently contribute to  excess cervical cancer mortality. To accomplish this aim, we will examine genomic and epigenomic alterations,  often not accounted for in most disparities-focused inquiry, as well as, develop novel statistical methodologies  to examine interactions between such factors, and social determinants of stage of disease at diagnosis and/or  survival. Study findings may inform future ?precision disparities? research, as well as, interventions to eliminate  the undue cervical cancer burden experienced by racial/ethnic minorities and the medically underserved","6516972; ","RAO, J SUNIL;","","","","Accounting; Address; Age; Attenuated; Automobile Driving; Awareness; base; Behavioral; Biological; Biology; burden of illness; Cancer Burden; cancer health disparity; cancer risk; cancer survival; Censuses; Cervix Neoplasms; Clinical; Cohort Studies; Communities; Complex; Computer software; Data; Data Set; demographics; Development; Diagnosis; Diet; Discipline; Disease; Disease Outcome; disease phenotype; DNA Methylation; epigenomics; ethnic minority population; Ethnic Origin; Etiology; experience; Future; genomic biomarker; Genomics; Grant; Health; health disparity; improved; Individual; interdisciplinary approach; Intervention; Malignant neoplasm of cervix uteri; Malignant Neoplasms; Maps; medically underserved; Methodology; Methods; methylome; Modeling; mortality; National Research Council; Nature; novel; Outcome; outcome forecast; Pathway interactions; Patients; Pattern; Play; Population; population health; precision medicine; Predisposition; primary endpoint; Programming Languages; Proxy; Race; racial and ethnic; racial difference; racial disparity; Research; residence; Risk; Risk Factors; Role; Sample Size; social; Socioeconomic Status; Somatic Mutation; Structure; Subgroup; Techniques; Testing; Text; The Cancer Genome Atlas; Time; United States; Universities; user friendly software; user-friendly; Vulnerable Populations; Woman; ","Project 1 - Precision disparity modeling of cervical cancer survival using genomic and social determinants","010722","ZMD1","Special Emphasis Panel ","8204","","04","322491","71754","","343080"
"9669085","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:279075\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","10974463; ","BUCKLEY, SHANNON ;","","","","Address; Affect; Award; B-Cell NonHodgkins Lymphoma; B-Lymphocytes; Basic Science; Biological Assay; cancer cell; Cell Compartmentation; Cell Line; Cell Lineage; Cells; Centers of Research Excellence; CRISPR/Cas technology; Cyclin D1; Cysteine; Defect; Development; Disease; Disease Progression; DNA Damage; drug discovery; embryonic stem cell; Engineering; experimental study; Frameshift Mutation; Future; Genomics; Hematopoiesis; Hematopoietic; high throughput screening; Immune; Immunoprecipitation; in utero; In Vitro; in vivo; insight; Knockout Mice; leukemia/lymphoma; lymph nodes; Lymphoid; Lymphoma; Lymphomagenesis; Maintenance; Malignant Neoplasms; Mantle Cell Lymphoma; Mantle Zone; Mass Spectrum Analysis; Molecular; Molecular Target; mortality; mouse model; multicatalytic endopeptidase complex; mutant; Mutate; Mutation; Myelogenous; Natural regeneration; Nebraska; new therapeutic target; next generation sequencing; Non-Hodgkin's Lymphoma; Nonsense Codon; Normal Cell; novel; Nuclear; overexpression; Patients; Play; Population; protein degradation; Proteins; Proteomics; recombinase-mediated cassette exchange; Research; Role; self-renewal; small hairpin RNA; small molecule; small molecule inhibitor; Stem cells; System; Testing; Therapeutic; therapeutic target; transcription factor; Translational Research; Ubiquitin; ubiquitin ligase; ubiquitin-protein ligase; Ubiquitination; Validation; Vascularization; Yolk Sac; ","Role of E3 Ligase, UBR5, in Hematopoietic Differentiation and Lymphomagenesis","121316","ZGM1","Special Emphasis Panel ","8789","","02","183000","96075","","279075"
"9671830","R01","AR","5","N","04/25/2019","03/01/2019","02/29/2020","846","R01AR044031","","PA-13-302","5R01AR044031-22","NIAMS:269940\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","OTTAWA","CANADA","","","201768095","CA","2202902","OTTAWA HOSPITAL RESEARCH INSTITUTE","ON","K1Y 4E9","PUBLIC HEALTH RELEVANCE:  Duchenne Muscular Dystrophy is a lethal muscle wasting disease that is caused by loss-of-function mutations in a gene called dystrophin. We have identified a novel role for dystrophin in regulating the polarity of muscle stem cells thus significantly impairing their function. We believe that our proposed studies will provide important insights into the biology of muscle regeneration and that such insights will potentially lead to new modalities of therapeutic intervention.","6825348; ","RUDNICKI, MICHAEL A;","BOYCE, AMANDA T","07/15/1996","02/28/2021","Actins; Acute; Affect; Antibodies; Binding; Biological; Biological Assay; Biology; Biopsy; Blood capillaries; Cell Compartmentation; Cell division; Cell physiology; Cell Polarity; Cells; Centrosome; Cessation of life; Childhood; Complex; Daughter; Disease Progression; Duchenne muscular dystrophy; Dystrophin; EGF gene; Engraftment; Environment; Epidermal Growth Factor Receptor; Exhibits; experimental study; functional restoration; Genes; Genetic; Homeostasis; Impairment; Injury; insight; Isoelectric Focusing; Lead; Length; Life; Ligation; loss of function mutation; mdx mouse; Mediating; Modality; Molecular; Mus; Muscle; muscle regeneration; Muscle satellite cell; Muscle Weakness; Muscular Atrophy; myogenesis; Myopathy; nanocomplexes ; Natural regeneration; Nature; novel; Patients; Performance; Phenotype; Play; progenitor; programs; prospective; public health relevance; Randomized; regenerative; Regulation; Regulatory Pathway; repaired; Reporting; restoration; Role; satellite cell; self-renewal; Signal Pathway; Signal Transduction; Skeletal Muscle; Stem cells; STK6 gene; Therapeutic Intervention; Time; Wasting Syndrome; ","Genetic Regulation of Skeletal Muscle Repair","044031","ZRG1","Special Emphasis Panel ","","","22","249944","19996","269940",""
"9671976","K01","MH","5","N","04/25/2019","04/24/2019","03/31/2020","242","K01MH112876","SCHOOLS OF MEDICINE","PA-16-190","5K01MH112876-04","NIMH:123582\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","MADISON","UNITED STATES","BIOSTATISTICS & OTHER MATH SCI","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","Project Narrative Bipolar disorder, a chronic disease of profound shifts in mood, is ranked as the seventh and eighth highest cause of disability among male and female adults by the World Health Organization. The aim of this project is to measure mood course in the moment, over time, in individuals, thus directing therapy to individuals when it is most needed. If successful, this project will (1) establish a mobile health platform for general use in developing effective adaptive interventions in bipolar disorder and (2) facilitate the transition of a junior researcher, at the interface of mathematics and psychiatry, into an independent researcher of effective adaptive interventions.","14532439; ","COCHRAN, AMY LOUISE;","CHAVEZ, MARK","12/04/2017","03/31/2021","actigraphy; acute symptom; Address; Adherence; Adult; Affect; Area; Award; base; Biological Markers; Bipolar Depression; Bipolar Disorder; bipolar patients; Caring; Characteristics; Chronic Disease; circadian; Circadian Rhythms; Clinical; Clinical assessments; clinical care; Clinical Trials; cohort; Complement; Data; Dimensions; disability; Disease; distinguished professor; Emotions; Event; evidence base; Evidence based practice; experience; Female; Goals; group intervention; Guidelines; Impairment; Individual; Intervention; Interview; Interviewer; Knowledge; Lead; male; Manic; Masks; Mathematics; Measures; Mental Depression; Mental Health; Mentored Research Scientist Development Award; Mentors; Methodology; mHealth; Michigan; Mind; Mission; Modeling; Monitor; Mood Disorders; mood symptom; Moods; National Institute of Mental Health; novel marker; Pathologic; Patient Self-Report; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Population; prevent; primary outcome; Process; professor; Psychiatry; psychosocial; Quality of life; Randomized; randomized trial; Recording of previous events; Recurrence; Relapse; Research; Research Personnel; Risk; Sample Size; Schedule; Sleep; statistics; Structure; Surrogate Markers; Surveys; Symptoms; Telephone; Testing; Time; Training; Translating; Translations; treatment group; trial design; two-dimensional; United States National Institutes of Health; Universities; wearable device; Woman; Work; World Health Organization; ","Modeling mood course to detect markers for effective adaptive interventions","112876","ZMH1","Special Emphasis Panel ","","","04","116155","7427","123582",""
"9672925","U19","AI","5","N","04/25/2019","04/01/2019","03/31/2020","","U19AI089688","","RFA-AI-15-056","5U19AI089688-10","NIAID:92232\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","The Malaria Evolution in South Asia International Center of Excellence for Malaria Research (MESA-ICEMR) will study the changing nature of malaria parasites in India. We are particularly interested in initiation of drug resistance as well as the pathways and ecological barriers to dissemination of such traits. Teams at unique sites spanning India will study malaria parasites in human hosts, mosquito vectors, and controlled laboratory studies after adaptation to answer these questions.","1859960; ","TULJAPURKAR, SHRIPAD D.;","","","","Administrator; Africa; Asia; base; Cells; Characteristics; Clinical; Clinical Research; clinical research site; Communication; Community Surveys; Computer software; Computers; Culicidae; Custom; Data; Data Collection; data management; Data Quality; Databases; Dictionary; Disease; Dissection; Drug resistance; Drug usage; Ensure; Evolution; Experimental Designs; Genomics; Government; Human; human disease; human subject; Imagery; Immunity; India; Institutes; interest; international center; Laboratories; Laboratory Study; Lead; Maintenance; Malaria; Manuscripts; Medical Research; member; Morbidity - disease rate; mortality; Nature; novel; Parasites; Pathology; Pathway interactions; Pattern; Phenotype; Plasmodium falciparum; Plasmodium vivax; Power Sources; Preparation; Procedures; protocol development; Quality Control; Reporting; Research; Research Design; Resource Sharing; Resources; response; Sampling; Scientist; Security; Shapes; sharing data; Site; Source; Statistical Data Interpretation; statistics; System; Time; Training; trait; transmission process; Universities; urban area; Variant; vector; vector mosquito; Washington; Work; ","Shared Resources Core","089688","ZAI1","Special Emphasis Panel ","5496","","10","122084","12093","","92232"
"9672928","U19","AI","5","N","04/25/2019","04/01/2019","03/31/2020","","U19AI089688","","RFA-AI-15-056","5U19AI089688-10","NIAID:52729\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","The Malaria Evolution in South Asia International Center of Excellence for Malaria Research (MESA-ICEMR) will study the changing nature of malaria parasites in India. We are particularly interested in initiation of drug resistance as well as the pathways and ecological barriers to dissemination of such traits. Teams at unique sites spanning India will study malaria parasites in human hosts, mosquito vectors, and controlled laboratory studies after adaptation to answer these questions.","14481152; ","KUMAR, ASHWANI ;","","","","Africa; Anopheles Genus; Antimalarials; Asia; Attention; Biological; Biology; Cells; Characteristics; Clinical Research; Collection; Community Surveys; Country; Culicidae; data management; Deforestation; Development; Disease; Disease Outbreaks; Dissection; Drug resistance; drug testing; Drug usage; Ecological Change; Ecology; Epidemiology; epidemiology study; Evolution; experimental study; feeding; Feeding behaviors; Genetic Crosses; genetic makeup; Genetic Variation; genome sequencing; Genotype; Geographic Locations; Government; Habitats; Hepatocyte; Human; human disease; Immunity; in vitro Model; India; Infection; Insecticides; interest; international center; Kinetics; Laboratory Study; Lead; Letters; Light; Location; Malaria; malaria transmission; Maps; mating behavior; Microscopic; migration; Minor; Molecular; Molecular Genetics; molecular scale; Morbidity - disease rate; Morphology; mortality; Nature; novel; Outcome; Parasite resistance; Parasites; Pathology; Pathway interactions; Patients; Pattern; Phenotype; Physiological; Plasmodium; Plasmodium falciparum; Plasmodium vivax; Population; Predisposition; product development; Program Development; programs; Research; resource guides; Resources; response; Scientist; Shapes; Site; Testing; trait; transmission process; urban area; Urbanization; Variant; vector; vector mosquito; whole genome; Work; ","Project B","089688","ZAI1","Special Emphasis Panel ","5499","","10","85582","9091","","52729"
"9674512","P20","GM","5","N","04/26/2019","04/01/2019","03/31/2020","","P20GM103440","","PAR-14-233","5P20GM103440-17","NIGMS:397752\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","Bioinformatics Core - Project Narrative The Nevada INBRE Bioinformatics Core will support research investigating Cell Growth and Differentiation by (1) Continuing to serve and support basic science research state-wide with a focus on current next-generation whole-genome sequencing studies and their biomedical applications, (2) Expanding to support the design and analysis of advanced clinical studies, and (3) Implementing a strong statewide Bioinformatics Outreach and Training Program to teach, train, and mentor undergraduate students in Nevada Outreach Institutions to enable them to incorporate Big Data and advanced analytical tools into biomedical research. These aims will facilitate researchers to perform state-of-the-art biomedical research and compete successfully for NIH funding.","8675168; ","SCHLAUCH, KAREN ;","","","","analytical tool; base; Basic Science; big biomedical data; Big Data; Big Data to Knowledge; Bioinformatics; Biomedical Research; cell growth; Clinical; Clinical Research; clinically relevant; Complex; computer infrastructure; computing resources; Data; Data Set; Databases; design; Differentiation and Growth; Disease; Educational workshop; Environmental Risk Factor; experience; Experimental Designs; experimental study; Funding; Generations; genome sequencing; genome wide association study; Genomic Segment; Genomics; Grant; Haplotypes; Institution; Learning; Medical Economics; Mentors; Methods; Multivariate Analysis; Nevada; next generation; next generation sequencing; outreach; outreach program; Pathway Analysis; programs; Proteomics; Research; Research Personnel; Research Support; Resources; Services; Site; SNP array; Social Network; sound; Specific qualifier value; Statistical Data Interpretation; Students; Technology; Testing; tool; Training; Training Activity; Training Programs; transcriptome; tutoring; undergraduate student; United States National Institutes of Health; Variant; whole genome; Work; ","Bioinformatics Core","103440","ZGM1","Special Emphasis Panel ","7787","","17","308903","88849","","397752"
"9677588","U01","EB","5","N","04/26/2019","04/01/2019","03/31/2020","286","U01EB023822","BIOMED ENGR/COL ENGR/ENGR STA","PAR-16-116","5U01EB023822-03","NIBIB:472079\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","MILWAUKEE","UNITED STATES","BIOMEDICAL ENGINEERING","04","046929621","US","4833601","MARQUETTE UNIVERSITY","WI","532011881","PUBLIC HEALTH RELEVANCE / PROJECT NARRATIVE This project will develop and validate a software tool to estimate the radiation dose delivered to a patient's organs when a patient undergoes a computed tomography (CT) examination. The proposed tool will estimate radiation dose to the patient's specific anatomy, whereas existing clinical software tools estimate radiation dose to a plastic cylinder or a model patient. Once developed, the tool can be used for radiation dose tracking, protocol optimization for dose reduction, and large-scale epidemiological studies for estimating cancer risk due to CT exams.","8834126; 8664252 (contact); ","JORDAN, PETR ; SCHMIDT, TALY GILAT (contact);","SHABESTARI, BEHROUZ","07/01/2017","03/31/2021","Abdomen; Accounting; Acute; Address; Adoption; Algorithms; Anatomy; Atlases; base; cancer risk; Case Study; Chest; Childhood; Clinical; clinical practice; Collaborations; commercialization; Computerized Medical Record; Data; Data Set; Databases; Dose; Engineering; epidemiology study; Equation; experimental study; Future; Goals; Gold; Image; Incidence; indexing; Individual; Industrialization; Informatics; Injury; innovation; International; Ionizing radiation; Malignant Neoplasms; Manuals; Maps; Medical; Medicine; Methods; Modeling; Monitor; National Institute of Biomedical Imaging and Bioengineering; novel; Organ; Overdose; Patients; pediatric patients; Pelvis; phantom model; Physics; Population; prevent; Procedures; Protocols documentation; prototype; Public Health; public health relevance; Radiation; Radiation Oncology; Radiation therapy; Radiology Specialty; Regulation; Reporting; Research; Resources; Running; Scanning; simulation; software development; Software Tools; symposium; System; Time; Tomography, Computed, Scanners; tool; Tube; Variant; Work; X-Ray Computed Tomography; ","Software tool for routine, rapid, patient-specific CT organ dose estimation","023822","ZRG1","Special Emphasis Panel ","","","03","406823","65256","472079",""
"9683204","F32","EB","1","N","02/22/2019","04/01/2019","03/31/2020","286","F32EB027587","GRADUATE SCHOOLS","PA-18-670","1F32EB027587-01","NIBIB:60854\","TRAINING, INDIVIDUAL","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","PRINCETON","UNITED STATES","CHEMISTRY","12","002484665","US","6661401","PRINCETON UNIVERSITY","NJ","085430036","Project Narrative Positron Emmision Tomography (PET) imaging with 18F-containing molecules is a useful tool in medicine for the diagnosis and progression of cancer or neurodegenerative diseases. There is currently no general and mild [18F]trifluoromethylation method for both aromatic and aliphatic molecules. We describe a photocatalytic decarboxylative nucleophilic fluorination that operates under ambient conditions and is applicable to a wide substrate scope, allowing access to new 18F radiotracers.","15434345; ","STEIMAN , TALIA  ;","ERIM, ZEYNEP","04/01/2019","03/31/2021","Alcohols; Amines; Area; Biological; catalyst; Cations; Chemistry; Clinical Research; Collaborations; Decarboxylation; design; Development; Diagnosis; Drug Industry; Esters; Fluorine; Fluvoxamine; functional group; Goals; Half-Life; high resolution imaging; High temperature of physical object; Image; In Situ; Isotopes; Label; Medical; Medicine; Metals; method development; Methodology; Methods; molecular imaging; Neurodegenerative Disorders; novel; oxidation; Oxidation-Reduction; Positron; Positron-Emission Tomography; Radioisotopes; radiotracer; Reaction; Reagent; Source; Techniques; Therapeutic; Time; tomography; tool; Translations; Trifluridine; tumor progression; Visible Radiation; Work; ","Visible Light Promoted Decarboxylative Trifluoromethylation for Application to PET Imaging","027587","ZRG1","Special Emphasis Panel ","","","01","60854","","60854",""
"9686379","P30","ES","2","N","04/26/2019","04/01/2019","03/31/2020","","P30ES000002","","RFA-ES-18-003","2P30ES000002-56","NIEHS:151892\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BOSTON","UNITED STATES","","07","149617367","US","3212904","HARVARD SCHOOL OF PUBLIC HEALTH","MA","021156028","","2198445; ","COULL, BRENT ANDREW;","","","","Area; Bayesian Method; Bioinformatics; Biometry; Biostatistics Core; Community Health; Community Outreach; Computational Biology; Computer software; computerized tools; Data; data management; Data Science; design; Development; Educational Activities; Environmental Epidemiology; Environmental Health; Faculty; Genetic; Genomics; graduate student; Health; Individual; Infrastructure; Interdisciplinary Study; interest; Journals; Measurement; Measures; meetings; member; Methodology; Methods; Mission; Modeling; National Institute of Environmental Health Sciences; Paper; Reproducibility; Research; Research Activity; Research Methodology; Research Personnel; Schools; Science; Services; spatiotemporal; Statistical Models; statistics; Teacher Professional Development; University resources; web page; Work; working group; ","Environmental Statistics and Biostatistics Core","000002","EHS","Environmental Health Sciences Review Committee ","5374","","56","95230","56662","","151892"
"9688240","R01","HD","5","N","04/26/2019","04/01/2019","03/31/2020","865","R01HD061665","SCHOOLS OF VETERINARY MEDICINE","PA-13-302","5R01HD061665-11","NICHD:313325\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","PULLMAN","UNITED STATES","VETERINARY SCIENCES","05","041485301","US","9082001","WASHINGTON STATE UNIVERSITY","WA","991641060","PUBLIC HEALTH RELEVANCE: The combined results from these studies will advance our understanding of fundamental mechanisms required for spermatogenesis and therefore male fertility. The continuity of spermatogenesis relies on actions of spermatogonial stem cells (SSCs) and studies in this project are designed to extend our understanding of molecular mechanisms influencing their fate decisions. The knowledge gained will be useful in determining causes of male infertility and in the generation of new diagnostic and treatment tools. Furthermore, results may also aid in devising strategies to protect the SSC pool from detrimental effects of chemotherapy and radiation therapy that often eliminate the germline of male cancer patients, resulting in infertility. Moreover, spermatogenesis is a classic model of stem cell dependent lineages, thus knowledge gained about the biology of SSCs may be applicable to stem cells in other tissues.","7263219; ","OATLEY, JON M;","MOSS, STUART B","09/30/2009","03/31/2020","Activity Cycles; Biology; Cancer Patient; Cell Cycle; Cell Cycle Progression; Cell Proliferation; chemotherapy; design; family influence; Generations; Helix-Turn-Helix Motifs; Infertility; Knowledge; Lead; Link; Maintenance; male; male fertility; Male Infertility; Mediating; member; Modeling; Molecular; mouse model; Mus; novel; novel diagnostics; Population; progenitor; public health relevance; Radiation therapy; Regulation; Repression; Resistance; response; Retinoic Acid Receptor; self-renewal; Signal Transduction; Spermatogenesis; Spermatogonia; stem cell biology; stem cell fate; stem cell population; Stem cells; stem-like cell; Testing; Tissues; tool; transcription factor; transcriptome; Tretinoin; ","Control of Spermatogonial Stem Cell Fate Decisions by HLH Factors","061665","CMIR","Cellular, Molecular and Integrative Reproduction Study Section ","","","11","207500","105825","313325",""
"9701964","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:232352\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","","6155044; ","WAGERS, AMY JO;","","","","Alleles; Animal Model; Area; base; biobank; Biological Models; Blood specimen; Cell Line; Cell Lineage; Cell model; cell type; Cells; Clinical; clinical heterogeneity; cohort; Collaborations; Collection; Communities; Complement; Consultations; cost effective; CRISPR/Cas technology; Custom; Databases; Defect; Deposition; design; Development; Diabetes Mellitus; diabetic; diabetic patient; Disease; Disease model; DNA; Elements; Embryo; Engineering; Epigenetic Process; Experimental Designs; Experimental Models; experimental study; Fibroblasts; functional genomics; Gene Deletion; gene replacement; Gene Targeting; Gene Transfer Techniques; Generations; Genes; Genetic; Genetic Heterogeneity; Genetic study; genetic variant; Genome; genome editing; Guide RNA; Human; human disease; human model; In Vitro; in vivo; in vivo evaluation; Individual; induced pluripotent stem cell; Insulin-Dependent Diabetes Mellitus; interest; knock-down; Knock-in; Knock-out; Laboratory mice; Link; Mediating; Medical Genetics; Messenger RNA; Methodology; Methods; Microinjections; Modeling; Modification; Molecular; mouse model; Mus; Non-Insulin-Dependent Diabetes Mellitus; novel; novel therapeutics; nuclear reprogramming; Pathology; Pathway interactions; patient population; Patients; peripheral blood; Phenotype; Pluripotent Stem Cells; pre-clinical; Production; Reagent; repository; Research; Research Personnel; Resources; response; RNA Interference; Sampling; Services; Somatic Cell; Source; Speed; Standardization; stem; stem cell technology; Sum; System; Techniques; Testing; Time; tool; Training; transcription factor; Transgenes; Translational Research; Update; Validation; zygote; ","Genome Editing Core","036836","ZDK1","Special Emphasis Panel ","7095","","33","137690","94662","","232352"
"9701966","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:369997\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","","1858731; ","SHOELSON, STEVEN E;","","","","Achievement; Administrator; Applications Grants; base; Biomedical Research; Budgets; Cardiovascular system; Clinical; Core Facility; Databases; Diabetes Mellitus; Eligibility Determination; Environment; experience; Failure; follow-up; Funding; Goals; Grant; Head; Immune Tolerance; Institutes; Institution; interest; Letters; medical schools; member; Metabolic Diseases; Methods; Names; novel; Pathogenesis; Population; Process; programs; Progress Reports; Published Comment; recruit; Reporting; Research; Research Institute; Research Personnel; Series; sound; Stem cells; Talents; Time; United States National Institutes of Health; web site; ","P&F Program","036836","ZDK1","Special Emphasis Panel ","7097","","33","219258","150739","","369997"
"9703504","P01","HL","1","N","04/22/2019","04/01/2019","03/31/2020","","P01HL146358","","PAR-18-405","1P01HL146358-01","NHLBI:31200\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","7355876; ","YOUNG, STEPHEN G.;","OLIVE, MICHELLE","","","Accounting; Agreement; Animal Experimentation; Annual Reports; Bibliography; California; Coffee; Collaborations; Communication; Computer Assisted; computer network; Computer software; Contract Services; Data; Data Files; Diné Nation; Discipline; Disease; Electronic Mail; Equipment; Equipment and supply inventories; Expenditure; Financial Support; follow-up; Funding; Grant; Health; Housing; Human Resources; International; laboratory equipment; Letters; Lipids; Location; Logistics; Manuscripts; material transfer agreement; Medicine; meetings; Movement; National Heart, Lung, and Blood Institute; Notification; novel strategies; Online Systems; Plasmids; Preparation; Procedures; Program Research Project Grants; Progress Reports; Protocols documentation; Publications; Radiation; Reagent; Reporting; Research Activity; Safety; Schedule; Scientist; Ships; skills; Supervision; symposium; System; Talents; Time; Training; Translating; Transportation; Travel; United States National Institutes of Health; Universities; Vendor; Word Processing; Work; Writing; ","Administration","146358","HLBP","Heart, Lung, and Blood Initial Review Group ","7803","","01","20000","11200","","31200"
"9703506","P01","HL","1","N","04/22/2019","04/01/2019","03/31/2020","","P01HL146358","","PAR-18-405","1P01HL146358-01","NHLBI:664190\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","7355876; ","YOUNG, STEPHEN G.;","OLIVE, MICHELLE","","","Affinity; Agonist; Amino Acids; ANGPTL3 gene; ANGPTL4 gene; Arterial Fatty Streak; ATP binding cassette transporter 1; Autoantibodies; Binding Sites; Biochemical; Blood capillaries; career; Cell Line; Cell membrane; Cells; Cholesterol; Collaborations; Complex; Coronary heart disease; Crystallization; Cytolysins; Disease; Dreams; Endothelial Cells; Fab Immunoglobulins; Failure; falls; Future; gain of function; Generations; Genetic; Genetic Polymorphism; Goals; Health; Heparan Sulfate Proteoglycan; High Density Lipoproteins; Histopathology; human disease; Hydrolase; Image; imaging genetics; imaging study; insight; interest; Intervention; Investigation; Lipids; Lipolysis; lipoprotein lipase; Lipoproteins; Liver X Receptor; loss of function mutation; macrophage; Mainstreaming; Mediating; Metabolic; Metabolism; Methodology; Molecular; Monoclonal Antibodies; Movement; mutant; Mutation; novel strategies; particle; Pathogenesis; Patients; Pharmacology; Plasma; Positioning Attribute; Preparation; Property; Proteins; Proteome; Publications; Reagent; recruit; Research; Research Personnel; reverse cholesterol transport; Role; Scanning Electron Microscopy; Starvation; Sterols; Structure; Tangier Disease; Technical Expertise; Textbooks; Triglyceride Metabolism; Triglycerides; Work; ","Deciphering Mechanisms for Triglyceride and Cholesterol Transport","146358","HLBP","Heart, Lung, and Blood Initial Review Group ","7805","","01","438200","225990","","664190"
"9710568","P30","AG","1","N","04/26/2019","04/01/2019","03/31/2020","","P30AG062422","","RFA-AG-19-001","1P30AG062422-01","NIA:238831\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","2095227; ","ROSEN, HOWARD J;","","","","accurate diagnosis; Alzheimer's Disease; Amyloid; analytical method; analytical tool; Anatomy; Archives; Autopsy; base; brain volume; Cerebrum; Classification; Clinical; Clinical Trials Design; cohesion; cohort; Collection; connectome; Creutzfeldt-Jakob Syndrome; Cross-Sectional Studies; Data; Data Set; Databases; Dementia; Development; diagnostic accuracy; Disease; drug discovery; Early Diagnosis; education research; Emotional; Enrollment; executive function; Expressed Sequence Tags; Functional Imaging; Functional Magnetic Resonance Imaging; genetic variant; Goals; Growth; Heterogeneity; Human; Image; Image Analysis; image archival system; imaging platform; imaging study; Imaging Techniques; improved; Individual; innovation; interest; Language; Leadership; Ligand Binding; Ligands; Linear Models; Link; longitudinal analysis; Machine Learning; Magnetic Resonance Imaging; Maintenance; Measures; Medical Genetics; method development; Methodology; molecular imaging; Multimodal Imaging; multimodality; Neurodegenerative Disorders; neuroimaging; Neurosciences; novel strategies; Pathologic; Patients; Perfusion; Positron-Emission Tomography; Presenile Alzheimer Dementia; Productivity; programs; Proteins; Protocols documentation; Publications; Quality Control; ranpirnase; rapid diagnosis; Research; Research Personnel; Research Support; Research Training; Rest; Role; Signal Transduction; skills; social; Supervision; System; tau Proteins; Techniques; tool; Training; Training Programs; Training Support; white matter; Work; ","Core F: Neuroimaging Core","062422","ZAG1","Special Emphasis Panel ","5038","","01","148882","89949","","238831"
"9718897","P30","AR","1","N","04/24/2019","04/15/2019","03/31/2020","846","P30AR074992","SCHOOLS OF MEDICINE","RFA-AR-19-002","1P30AR074992-01","NIAMS:783125\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","SAINT LOUIS","UNITED STATES","ORTHOPEDICS","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","Project Narrative - Overall Musculoskeletal conditions affect one in two Americans. We are a group of 80+ researchers who study the underlying causes for musculoskeletal diseases like arthritis, back pain and osteoporosis. With this knowledge, we develop and test new strategies to treat these diseases, primarily using small animals to test proof of concept.","2477081; ","SILVA, MATTHEW J;","KIRILUSHA, ANTHONY G","04/15/2019","03/31/2024","Address; Adult; Affect; Age; American; Animal Model; Animals; Anti-inflammatory; Area; Arthralgia; Arthritis; arthropathies; Award; Back Pain; base; Basic Science; Behavior; Biological; Biological Testing; Biology; Biomechanics; bone; bone mass; Cancer Grant Supplements (P30); Cartilage; Cells; cellular imaging; Collaborations; Communities; Confocal Microscopy; cost; cost effective; Degenerative polyarthritis; Development; Disease; Disseminated Malignant Neoplasm; Engineering; Epigenetic Process; Evaluation; Fostering; Funding; Goals; Grant; Histology; imaging modality; Impairment; improved; in vivo; Interdisciplinary Study; Intervention; joint function; joint injury; Knowledge; Leadership; Ligaments; Maintenance; Measures; mechanical properties; Medicine; Metastatic Neoplasm to the Bone; Methods; Microscopy; Morphology; morphometry; Motion; mouse model; Muscle; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural regeneration; next generation; Osteoporosis; outreach; Paper; Population; preclinical study; prevent; Productivity; professor; programs; Protocols documentation; Publications; Publishing; recruit; repository; Reproducibility; Research; Research Personnel; Research Support; Resources; Rheumatoid Arthritis; Roentgen Rays; Sampling; Series; Serum; Services; Stains; Structure; symposium; Techniques; Tendon structure; Testing; therapeutic development; Time; tissue processing; Tissues; Training; Training Support; Translational Research; United States; United States National Institutes of Health; Universities; University resources; Washington; Work; ","Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)","074992","ZAR1","Special Emphasis Panel ","","","01","500000","283125","783125",""
"9720717","IK2","VA","1","N","04/24/2019","04/01/2019","03/31/2020","999","IK2RX002688","","RFA-RX-18-016","1IK2RX002688-01A2","","OTHERS","2019","Veterans Affairs","","INDIANAPOLIS","UNITED STATES","","07","608434697","US","481029","RLR VA MEDICAL CENTER","IN","462022803","Amyotrophic lateral sclerosis (ALS) is a common, devastating neurodegenerative disease that affects thousands of Americans, with Veterans at increased risk. As such, ALS is a major global health concern. Unfortunately, no truly effective treatments or cures for ALS exist. Evidence of disease is detectable long before symptoms start in the disconnection of spinal cord motor neurons from target muscles, which leads to later paralysis. Adipose- derived stem cells (ASCs) release various growth and protective factors that have proven effective in reducing disease severity in a common experimental animal model of ALS. We have found early administration of these released beneficial factors lessen the extent of this neuromuscular disconnection in this animal model. The proposed study is designed to test whether taking secreted factors from ASCs and delivering it systemically over different time periods, or directly into the muscle in a novel bioengineered therapy, can delay symptoms, slow disease progression and functional decline, and extend survival in experimental ALS.","10315575; ","WALKER, CHANDLER ;","","04/01/2019","03/31/2024","Acute; Acute Lung Injury; Adipose tissue; Affect; American; Amyotrophic Lateral Sclerosis; Animal Model; Anti-inflammatory; Apoptosis; Apoptotic; Area; Axon; Biocompatible Materials; Biomedical Engineering; Blood specimen; Blood Vessels; Cardiovascular Pathology; Cell Culture Techniques; Cells; Cessation of life; Chronic; clinical application; clinical candidate; clinical efficacy; clinical translation; Collaborations; Conditioned Culture Media; crosslink; cytokine; design; Diagnosis; Disease; Disease Progression; Dose; effective therapy; Electromyography; Elements; Engineering; Experimental Animal Model; experimental study; functional decline; functional loss; Gastrocnemius Muscle; global health; Growth; Growth Factor; Gulf War; Hand Strength; Histologic; Histology; Hybrids; Hydrogels; Immune; immune activation; Immune response; Immunologic Markers; Immunologics; improved; In Vitro; in vivo; Indiana; Individual; ineffective therapies; Inflammation; Inflammatory; inflammatory marker; Inflammatory Response; Injectable; Injections; invention; Investigation; Ischemia; Kinetics; Light; Limb structure; Longevity; loss of function; Lumbar spinal cord structure; Medial; Motor Activity; Motor Neurons; mouse model; Mus; Muscle; Neuraxis; Neurodegenerative Disorders; neuromuscular; neuromuscular function; Neuromuscular Junction; neuron loss; novel; novel therapeutics; Onset of illness; Paralysed; Pathologic; Pathology; Patients; Peripheral; Persian Gulf; Phase I Clinical Trials; Polyethylene Glycols; Population; preservation; protective factors; Quality of life; relating to nervous system; repaired; Research; response; Risk; Severity of illness; Site; Skeletal Muscle; Spinal Cord; stem; Stem cells; Stromal Cells; Symptoms; Testing; Therapeutic; Therapeutic Effect; Time; Tissue Sample; Tissues; treatment effect; Treatment Efficacy; Treatment Protocols; United States; Universities; Veterans; ","Adipose-derived stem cell-conditioned medium therapy in a mouse model of ALS","002688","RRD8","Career Development Program - Panel I ","","A2","01","","","",""
"9727583","R03","DK","1","N","04/24/2019","04/25/2019","03/31/2020","847","R03DK121061","SCHOOLS OF MEDICINE","PAR-18-103","1R03DK121061-01","NIDDK:120281\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","SAN FRANCISCO","UNITED STATES","PEDIATRICS","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","Project Narrative Investigations into the Gut-Brain axis are undergoing a resurgence thanks to new technology that allows for detailed studies of the intestinal lining and its associated innervation. This proposal seeks to understand how the differentiation of specialized gut sensory cells is influenced by the nuclear LRH-1 and together how this affects intestinal function.","10592679; ","BAYRER, JAMES ;","SASLOWSKY, DAVID E","04/25/2019","03/31/2021","Acute; Affect; Anatomy; Apoptosis; Biology; Body Surface Area; Cell Count; cell dedifferentiation; Cell Differentiation process; Cell Lineage; cell motility; Cell Survival; cell type; Cells; Chemicals; ChIP-seq; colorectal distension; Communication; Complement; Coupled; crypt cell; Data; data submission; design; Development; Digestion; DNA Binding; Embryonic Development; Enteroendocrine Cell; Epithelial; Epithelial Cells; Epithelial Physiology; Esthesia; Evaluation; experimental study; Feces; gastrointestinal epithelium; Gastrointestinal tract structure; Gastrointestinal Transit; Genetic; Genetic Transcription; Goals; gut-brain axis; Histologic; Homeostasis; In Situ Hybridization; intestinal crypt; intestinal epithelium; Intestinal Motility; Intestinal Secretions; Intestines; Investigation; Knock-out; Label; Lead; LGR5 gene; Liquid substance; live cell imaging; Maintenance; Measures; Mechanics; Metabolic; Metabolism; Modeling; Molecular; mouse model; Mucous Membrane; Multipotent Stem Cells; Nerve Fibers; nerve supply; Neurons; neurotransmission; new technology; notch protein; Notch Signaling Pathway; NR5A2 gene; Nuclear; Nuclear Receptors; Organoids; Pathogenicity; Phenotype; Play; pluripotency; Population; Production; programs; Property; Proxy; rapid growth; Reporter; Research; response; Role; Secretory Cell; Sensory; Signal Transduction; single cell sequencing; single-cell RNA sequencing; Stem cells; Stimulus; Synapses; System; Technology; Time; time use; Visceral; Water; Work; ","Uncovering the role of LRH-1 in enteroendocrine cell development and ?gut-brain? communication","121061","DDK","Kidney, Urologic and Hematologic Diseases D Subcommittee ","","","01","75000","45281","120281",""
"9729350","U19","AI","2","N","04/22/2019","04/25/2019","03/31/2020","","U19AI110818","","RFA-AI-18-004","2U19AI110818-06","NIAID:408821\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","","07","623544785","US","10021177","BROAD INSTITUTE, INC.","MA","021421027","","1921493; ","NUSBAUM, HARRIS CHAD;","","","","Area; Bacteria; Biological Sciences; Cells; combat; Communicable Diseases; cost; Data; Data Element; Data Quality; Diagnosis; Drug resistance; experience; fungus; gene function; Generations; Genome; genomic data; Genomics; Goals; Hybrids; improved; Individual; infectious disease treatment; Infectious Diseases Research; innovation; Institutes; Knowledge; Laboratories; metagenomic sequencing; Methodology; Methods; microbial community; Mission; nanopore; new technology; Nucleic Acids; Office of Administrative Management; operation; Parasites; pathogen; Plasmids; Population; Preparation; Prevention; Process; Proteomics; Protocols documentation; Research; Research Project Grants; ribosome profiling; Sampling; single cell sequencing; success; succinylated wheat germ agglutinin; Technical Expertise; Technology; Testing; transcriptome sequencing; transmission process; vector; Virulence; Virus; Work; ","Technology Core","110818","ZAI1","Special Emphasis Panel ","5977","","06","262012","146809","","408821"
"9733580","R01","HG","1","N","04/22/2019","04/22/2019","01/31/2020","172","R01HG010538","BIOMED ENGR/COL ENGR/ENGR STA","RFA-HG-18-001","1R01HG010538-01","NHGRI:845045\","Non-SBIR/STTR RPGs","2019","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","BALTIMORE","UNITED STATES","BIOMEDICAL ENGINEERING","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Project Narrative: The central dogma of biology tells us that DNA is transcribed to RNA, which then encodes protein. But there are complicated regulatory layers which serve to control this biology, layers which are poorly understood and often go awry in disease. We are developing a new toolset which will, for the first time, allow us to examine RNA directly to probe its structure and dynamics, granting new insights into its biology.","9427136; ","TIMP, WINSTON GEORGE;","SMITH, MICHAEL","04/22/2019","01/31/2023","Address; Affect; base; Base Pairing; Binding Proteins; Biology; Cell physiology; Cells; Charge; Chemical Structure; Chemicals; Chemistry; Communicable Diseases; Complementary DNA; Complex; Data; Data Set; design; Detection; Disease; DNA; DNA Sequence; Event; experimental study; Generations; Genetic Diseases; Genetic Transcription; Genomics; Grant; human disease; Ice; Immunoprecipitation; Inosine; insight; Internet; Kinetics; Label; Ligation; Literature; Maps; Measurement; Measures; Messenger RNA; Metabolic; method development; Methodology; Methods; Modeling; Modification; Molecular; multimodality; nanopore; novel; Nucleotides; Oligonucleotides; Pattern; Physiologic pulse; preservation; Production; Property; Proteins; Pseudouridine; reconstruction; Research Personnel; Resolution; RNA; RNA Processing; RNA Sequences; RNA Splicing; scaffold; sequencing platform; Series; Shapes; Signal Transduction; single molecule; Site; Structure; Techniques; Technology; Thiouridine; Time; time use; TimeLine; tool; Training; Transcriptional Regulation; transcriptome; transcriptome sequencing; Translating; Variant; Work; ","Direct nanopore detection of modified RNA to probe structure and dynamics","010538","ZHG1","Special Emphasis Panel ","","","01","705774","139271","845045",""
"9736461","R01","HD","5","N","04/25/2019","04/01/2019","03/31/2020","865","R01HD089420","SCHOOLS OF MEDICINE","PAR-17-189","5R01HD089420-02","NICHD:601963\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","IOWA CITY","UNITED STATES","ANESTHESIOLOGY","02","062761671","US","3972901","UNIVERSITY OF IOWA","IA","522421320","PROJECT NARRATIVE  Research has shown that general anesthesia causes brain injury in young animals. Millions of young human children are exposed to general anesthesia annually, which is of great public health concern given the very real possibility that such exposure could result in abnormalities in brain and cognitive development that might have life-long consequences. The primary objective of this proposal is to help fill a critical gap in knowledge concerning the consequences of exposure to general anesthesia during early childhood on brain structure, brain function, and cognition, and, in this way, provide information about its risks that might change best practices for clinical care of children with a variety of disorders who currently are exposed to general anesthesia.","1967401; ","BLOCK, ROBERT I;","MANN KOEPKE, KATHY M","07/01/2018","03/31/2023","Academic achievement; achievement test; Address; Adolescent; Adverse effects; Age; Anesthetics; Animals; Anisotropy; Apoptosis; base; Behavioral; Birth; Brain; Brain Injuries; Brain region; brain tissue; Characteristics; Child; Child Care; Childhood; clinical practice; Cognition; Cognitive; cognitive development; cognitive function; cognitive testing; Comorbidity; Conduction Anesthesia; critical developmental period; Data; Development; Diffuse; Diffusion Magnetic Resonance Imaging; Disease; early childhood; Environment; Ethnic Origin; Exposure to; Family; Frequencies; Functional Magnetic Resonance Imaging; Future; Gender; General Anesthesia; gray matter; Human; Impaired cognition; Individual; juvenile animal; Knowledge; Label; Laboratories; Language; Learning; Life; long term memory; Magnetic Resonance Imaging; Measures; Mediation; Memory; memory recognition; myelination; Neuraxis; neuroimaging; Neurologic; Neurons; neurotoxicity; Oligodendroglia; Pattern; Performance; performance tests; premature; Premature Birth; primary outcome; Procedures; Public Health; Race; recruit; regional difference; Research; Rest; Risk; Risk Factors; Short-Term Memory; Statistical Data Interpretation; Structure; Structure-Activity Relationship; Techniques; Testing; United States National Institutes of Health; Visual; Visual impairment; white matter; ","General Anesthesia During Early Childhood and Brain Development","089420","ZRG1","Special Emphasis Panel ","","","02","394730","207233","601963",""
"9748774","R01","AI","2","N","04/24/2019","04/23/2019","03/31/2020","855","R01AI064478","SCHOOLS OF PUBLIC HEALTH","PA-18-484","2R01AI064478-12A1","NIAID:615144\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","TAMPA","UNITED STATES","OTHER HEALTH PROFESSIONS","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","Narrative Malaria is a significant global health problem and Plasmodium vivax is the major cause of non-African malaria, causing 16 million cases of clinical malaria in 2013 at an estimated cost of $1.4 - $4 billion per year. Widespread drug resistance, the relapsing nature of P. vivax, and emerging virulent forms of P. vivax emphasizes the critical need for development of a vaccine against P. vivax. Our overall goal is to develop a vaccine to eliminate vivax malaria as a major health problem.","1888906; ","ADAMS, JOHN H;","MO, ANNIE X Y","08/01/2006","03/31/2024","Address; Adjuvant; Affect; Affinity; Age; Amino Acid Substitution; Animals; Antibodies; Antibody Response; Antigen Receptors; Antigens; Area; B-Lymphocyte Epitopes; B-Lymphocyte Subsets; B-Lymphocytes; base; Binding; Binding Proteins; Biological; Blood; Brazil; cell mediated immune response; Cells; chemokine receptor; Clinical; Cohort Studies; Collaborations; cost; Cross-Sectional Studies; Data; design; Development; dimer; Disease; Dose; Drug resistance; Engineering; Epitopes; Evaluation; Formulation; Genes; Genetic Polymorphism; global health; Goals; Health; HIV; HIV Envelope Protein gp120; Human; human monoclonal antibodies; Immune; Immune response; Immunity; Immunization; Immunization Schedule; immunogenic; immunogenicity; Immunoglobulin G; Immunologic Memory; Immunologics; Immunology; improved; in vitro Assay; Individual; Infection; Kinetics; Life; Ligands; long term memory; Malaria; Mediating; Memory; Memory B-Lymphocyte; Methods; microbial; Mus; Natural Immunity; Nature; Outcome; Parasites; Parasitology; Patients; Phenotype; Plasmodium vivax; Preclinical Testing; Problem Solving; Production; programs; protein expression; protein purification; Protocols documentation; receptor; Recombinant Proteins; Recombinants; Regimen; Relapse; response; Reticulocytes; sex; Solid; Solubility; Specificity; structural biology; Surface; System; T-Lymphocyte; Tertiary Protein Structure; tool; Transcend; Vaccination; vaccination strategy; vaccine candidate; Vaccine Design; vaccine development; vaccine efficacy; Vaccines; vaccinology; Variant; Virulent; Vivax Malaria; ","Immunological characterization of the P. vivax DBP","064478","VMD","Vaccines Against Microbial Diseases Study Section ","","A1","12","431869","183275","615144",""
"9755165","R01","AI","1","N","04/22/2019","04/22/2019","03/31/2020","855","R01AI145096","SCHOOLS OF MEDICINE","PA-18-484","1R01AI145096-01","NIAID:570000\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW ORLEANS","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","01","053785812","US","8424601","TULANE UNIVERSITY OF LOUISIANA","LA","701185665","NARRATIVE/PUBLIC HEALTH RELEVANCE Polymicrobial IAI and sepsis are clinically devastating infections with high mortality. There is no available vaccine and antimicrobial/immunosuppressive therapy is often unsuccessful. Our data indicate that Candida species can induce trained innate immunity that can provide >90% protection against lethal polymicrobial IAI. This work will provide the first evidence for the induction of Gr-1+ MDSCs in long-term innate protection, a role previously restricted to macrophages. These studies have broad clinical significance and the potential to reveal paradigm shifting new facets of trained innate immunity that could lead to translational therapeutic strategies.","8486739; ","NOVERR, MAIRI C;","LOVE, DONA","04/22/2019","03/31/2024","Abdominal Infection; adaptive immunity; Animal Model; Anti-inflammatory; Antibodies; antimicrobial; Candida; Candida albicans; cell type; Cells; Clinical; clinically significant; co-infection; Communicable Diseases; cytokine; Data; Dinoprostone; Disease; Epigenetic Process; Exposure to; Gastrointestinal tract structure; gene complementation; Gene Expression; Human; Immune; Immunity; in vivo; Infection; inhibitor/antagonist; interest; Intra-abdominal; Knockout Mice; Lead; Leukocytes; Ligands; macrophage; Mediating; Memory; Methods; microbial; Modification; Morphogenesis; mortality; Mus; Mycoses; Myeloid-derived suppressor cells; Natural Immunity; novel; Organism; pathogen; pathogenic fungus; Pathway interactions; Patient risk; Phenotype; polymicrobial sepsis; programs; public health relevance; Reporting; response; Risk Factors; Role; S100A9 gene; secondary infection; Secondary to; Sepsis; Signal Induction; Signal Transduction; Staphylococcus aureus; Suggestion; Survivors; synergism; Testing; Therapeutic; Therapeutic immunosuppression; Training; Vaccines; Virulence; Work; ","Candida mediated protection against polymicrobial sepsis","145096","ZRG1","Special Emphasis Panel ","","","01","376859","193141","570000",""
"9778165","I01","VA","1","N","04/26/2019","04/01/2019","03/31/2020","999","I01BX004315","","RFA-BX-18-001","1I01BX004315-01A2","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","CHICAGO","UNITED STATES","","07","010299204","US","481026","JESSE BROWN VA MEDICAL CENTER","IL","606123728","The prevalence of Alzheimer?s disease (AD) is much greater in the veterans than in general population, but there is no effective treatment for it. Because of the well-known beneficial effects of docosahexaenoic acid (DHA), an omega 3 fatty acid, for the brain, it has been used with some success in the animal models of AD. However, clinical trials with the currently available DHA supplements (fish oil, krill oil, ethyl esters) have been unsuccessful in improving cognitive function in patients, apparently because of the inability of these supplements to increase brain DHA levels at the safe doses recommended by FDA. This proposal aims to develop a novel approach, employing a tailored phospholipid form of DHA, which specifically enriches brain DHA and improves memory at low doses. The potential of this compound in the prevention or mitigation of AD, and the underlying mechanisms of its action will be investigated, employing a mouse model of AD.","1882817; ","SUBBAIAH, PAPASANI V;","","04/01/2019","03/31/2023","absorption; Acetylcholine; Affect; Age; Alzheimer disease prevention; Alzheimer's Disease; Alzheimer's disease model; American; Animal Model; Animals; Anti-inflammatory; base; Behavior; Blood - brain barrier anatomy; Brain; brain tissue; Brain-Derived Neurotrophic Factor; Choline; Clinical Trials; Cognition; Cognitive; cognitive function; cost; Data; Dementia; Development; Diet; Disease; Disease model; Docosahexaenoic Acids; Dose; effective therapy; Effectiveness; Eicosapentaenoic Acid; Esters; Ethanolamines; Euphausiacea; Failure; Fish Oils; General Population; Head; high risk; Hydrolysis; improved; Intestinal Absorption; Intestines; Lead; Lysophosphatidylcholines; Lysophospholipids; Memory; Mental Depression; Metabolic; mouse model; Mus; Nerve Tissue; nervous system disorder; neuroinflammation; neuropathology; novel; novel strategies; Nutraceutical; Oils; Omega-3 Fatty Acids; Oxides; Parkinson Disease; Pathologic; Pathology; Patients; Phospholipids; Population; Post-Traumatic Stress Disorders; Prevalence; prevent; Prevention; Prevention strategy; Rattus; Risk Factors; Schizophrenia; Serine; spatial memory; success; Symptoms; Testing; Transgenic Mice; Traumatic Brain Injury; Triglycerides; Veterans; ","Novel strategy to enrich brain DHA through diet: Potential application for the prevention of Alzheimer's disease","004315","ZRD1","Special Emphasis Panel ","","A2","01","","","",""
"9572662","P30","EY","2","N","04/25/2019","04/01/2019","03/31/2020","","P30EY008098","","PAR-17-322","2P30EY008098-31","NEI:117574\","RESEARCH CENTERS","2019","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","","1883362; ","FUNDERBURGH, JAMES L;","","","","Cell Culture Techniques; Consult; Consultations; Core Grant; experience; Experimental Designs; flexibility; Goals; Histological Techniques; Histology; investigator training; light microscopy; Maintenance; Preparation; protocol development; Research Personnel; Sampling; Services; Techniques; tissue culture; tissue preparation; Training; Training Activity; Virus; Vision; Vision research; ","Tissue Culture and Histology Core","008098","ZEY1","Special Emphasis Panel ","5950","","31","75127","42447","","117574"
"9572665","P30","EY","2","N","04/25/2019","04/01/2019","03/31/2020","","P30EY008098","","PAR-17-322","2P30EY008098-31","NEI:27434\","RESEARCH CENTERS","2019","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","","7892660; ","SMITH, MATTHEW A;","","","","Conceptions; Core Grant; Custom; design; Development; Devices; Equipment; experimental study; Faculty; Goals; Imagination; Laboratories; Methods; Production; prototype; Research; Research Personnel; Research Project Grants; Resources; Training; Vision; Vision research; ","Custom Fabrication Core","008098","ZEY1","Special Emphasis Panel ","5953","","31","17530","9904","","27434"
"9627749","U10","CA","2","N","04/23/2019","04/19/2019","02/29/2020","","U10CA180899","","RFA-CA-17-057","2U10CA180899-06","NCI:2819497\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","OAKLAND","UNITED STATES","","13","128663390","US","1618201","PUBLIC HEALTH INSTITUTE","CA","946074046","","1857551; ","ALONZO, TODD A;","","","","Adolescent; Adverse event; anticancer research; Australia; base; Biology; Canada; Cancer Center; Cancer Patient; Child Support; Childhood; Childhood Cancer Treatment; Clinical; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Design; Collaborations; Collection; Communities; Companions; Country; Data; data management; design; Diagnosis; Disease; Ensure; Family; Foundations; functional outcomes; Generations; Goals; improved outcome; Industry; Infrastructure; innovation; Interdisciplinary Study; Knowledge; Laboratories; Leadership; Malignant Childhood Neoplasm; member; Methods; Molecular; Monitor; multidisciplinary; New Zealand; organizational structure; Outcome; Patients; Pediatric Hospitals; Pediatric Oncology Group; Phase; Procedures; Process; programs; Quality of life; Reporting; Research; Research Personnel; research study; Science; statistics; Survivors; Time; translational clinical trial; Translational Research; translational study; United States; Universities; ","COG SDMC - Data Management Core","180899","ZCA1","Special Emphasis Panel ","8348","","06","2638431","406709","","2819497"
"9656162","R03","HD","5","N","04/22/2019","04/01/2019","03/31/2020","865","R03HD094978","","PA-16-162","5R03HD094978-02","NICHD:80850\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","ORANGEBURG","UNITED STATES","","17","167204762","US","1590925","NATHAN S. KLINE INSTITUTE FOR PSYCH RES","NY","109621157","Project Narrative One of the most important environmental factors influencing brain development, and later vulnerability to maladaptive behaviors, is maternal care. In this study, we propose to test the hypothesis that the mother?s presence or absence regulates the activity of key prefrontal regions of the brain in 11 day-old rat pups through the serotonergic system. Understanding how maternal presence affects neural activity during early life would provide key insights into how maternal care affects the adaptive/maladaptive development of brain circuits.","12164193; ","TEIXEIRA, CATIA ;","MANN KOEPKE, KATHY M","04/01/2018","03/31/2020","Address; Adrenal Glands; Adult; Affect; Animals; Behavior; Behavioral; Brain; Brain region; Caregivers; Caring; Child; critical period; Data; Development; Emotional; Environment; Environmental Risk Factor; experimental study; Fluoxetine; Food; Frequencies; genetic variant; Glucocorticoid Receptor; hippocampal pyramidal neuron; Infant; insight; Ketanserin; Life; Measures; Mediating; Mental Health; Morphology; Mothers; neglect; Neuromodulator; neuron development; neuronal circuitry; Neurons; Nipples; Orphanages; Pattern; perinatal period; Pharmacologic Substance; physical abuse; Pilot Projects; Pituitary Gland; postnatal; postsynaptic; Prefrontal Cortex; pup; Rattus; receptor; receptor expression; Recreational Drugs; Regulation; relating to nervous system; Research Project Grants; response; Rodent; Role; Saline; Sample Size; Selective Serotonin Reuptake Inhibitor; serotonergic regulation; Serotonergic System; Serotonin; Shapes; Signal Transduction; Stress; Tactile; Testing; Wireless Technology; Work; ","Maternal presence modulates pups' brain activity via the serotonergic system","094978","CHHD","National Institute of Child Health and Human Development Initial Review Group ","","","02","50000","30850","80850",""
"9663986","R01","HL","5","N","04/25/2019","04/01/2019","03/31/2020","837","R01HL133127","","PA-16-160","5R01HL133127-03","NHLBI:518326\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","PROJECT NARRATIVE The proposed research is relevant to public health because the disease under study, atrial fibrillation, is the most common cardiac arrhythmia of clinical significance, and it represents an increasing cause of cardiovascular morbidity and mortality in the US. The proposed studies have substantial significance for the general population, given that the hypotheses we are testing may not only provide mechanistic links between common diseases such as hypertension and obesity with atrial fibrillation, but they may also provide novel therapeutic targets for the prevention and/or treatment of this common and difficult to treat arrhythmia. This project is relevant to the NIH's mission because the impact of these findings on clinical practice could be substantial, and the knowledge that will result should improve health and prevent disease in the US.","1926102; ","MURRAY, KATHERINE T;","SHI, YANG","04/01/2017","03/31/2021","Aging; Aldehydes; Alzheimer's Disease; Amyloid; Amyloidosis; Angiotensin II; Arrhythmia; Atrial Fibrillation; Atrial Natriuretic Factor; base; Binding; Biological; Cardiac; Cardiac Surgery procedures; Cardiovascular system; cell injury; Cells; clinical practice; clinical risk; Clinical Trials; clinically significant; common treatment; cytotoxic; Data; Disease; Disease Progression; Electrophysiology (science); Functional disorder; General Population; Generations; Genes; Goals; Health; Heart Atrium; Hereditary Disease; Homeostasis; Human; human disease; Hypertension; improved; in vivo Model; Injury; Interruption; Knowledge; Link; Lipid Peroxidation; Lipids; Mediating; Mediator of activation protein; Microscopic; misfolded protein; Mission; Modeling; Molecular Target; Morbidity - disease rate; mortality; mouse model; Mus; Muscle Cells; mutant; Mutation; new therapeutic target; novel; novel strategies; Obesity; Outcome; Oxidative Stress; Pathogenesis; Pathologic Processes; Patients; peptide A; Peptides; Predisposition; prevent; Prevention; Process; Proteins; proteotoxicity; Public Health; Reactive Oxygen Species; Research; Risk Factors; Role; success; Testing; therapeutic target; therapy design; Tissues; tool; United States National Institutes of Health; ","Novel Pathophysiological Targets in Atrial Fibrillation Susceptibility","133127","CICS","Clinical and Integrative Cardiovascular Sciences Study Section ","","","03","338772","179554","518326",""
"9665759","K22","HL","5","N","04/25/2019","04/01/2019","03/31/2020","839","K22HL125593","EARTH SCIENCES/RESOURCES","PAR-12-137","5K22HL125593-03","NHLBI:249000\","OTHER RESEARCH-RELATED","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","WEST LAFAYETTE","UNITED STATES","BIOCHEMISTRY","04","072051394","US","1481402","PURDUE UNIVERSITY","IN","479072114","Project Narrative Dysregulation of T helper cell responses typically leads to various immune-mediated diseases such as allergy and asthma. There is growing evidence that noncoding RNAs play a significant role in regulation and plasticity of T helper cells. In this proposal, we identify enhancer RNAs, a recently discovered class of noncoding RNAs, and characterize their role in several T helper cell populations. Identification of enhancer RNAs in T helper cells may lead to the discovery of novel therapeutics for T helper cell related disorders.","12083435; ","KAZEMIAN, MAJID ;","CHANG, HENRY","04/01/2017","03/31/2020","adaptive immune response; Address; Affect; Asses; Asthma; Award; Binding; Binding Proteins; Biological; Biological Assay; Biological Sciences; career development; Cell Culture Techniques; Cell Differentiation process; cell type; Characteristics; Chromatin; Cloning; Complex; Computational Science; Computational Technique; Computer Analysis; Coupled; cytokine; Development Plans; Disease; DNA; DNA Binding; Education; Educational workshop; Enhancers; Ensure; Equipment; experimental study; fight against; Flow Cytometry; Foundations; Future; Gene Expression; Gene Expression Regulation; gene therapy; Genes; genetic signature; Genetic Transcription; Genome; genome-wide; Genomic DNA; Genomics; Health; Helper-Inducer T-Lymphocyte; high throughput screening; High-Throughput Nucleotide Sequencing; Hypersensitivity; Immune; Immune system; Immune System Diseases; improved; Interview; knock-down; Knowledge; Laboratories; laboratory experience; Laboratory Research; Lead; Learning; Libraries; Location; macrophage; Measures; Mediating; Mentors; method development; Modeling; Monitor; mRNA Expression; Mus; National Heart, Lung, and Blood Institute; novel; novel strategies; novel therapeutics; Occupations; Partner in relationship; pathogen; Pathway interactions; Phase; Play; Population; post-doctoral training; Preparation; Production; Protocols documentation; Regulation; Reporter; Research; response; RNA; RNA Polymerase II; RNA purification; Role; Secondary Protein Structure; Signal Pathway; skills; spatiotemporal; Specific qualifier value; STAT protein; Students; Supervision; Symptoms; T-Cell Development; Techniques; Technology; Time; Training; Transcriptional Regulation; Transfection; undergraduate student; Untranslated RNA; ","Expression, regulation, and role of enhancer RNAs in T helper cells","125593","ZHL1","Special Emphasis Panel ","","","03","230556","18444","249000",""
"9669084","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:279075\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","10367499; ","WEN, HAITAO ;","","","","Acute; Affect; Anabolism; Anti-inflammatory; Attenuated; base; Biochemical; cancer clinical trial; Cells; Cessation of life; Chemicals; Chemosensitization; Colitis; Collaborations; Colon; Colon Carcinoma; colon tumorigenesis; Colorectal Cancer; colorectal cancer risk; Complication; CUL3 gene; cullin-3; cytokine; Development; Disease; Endoscopy; Enzymes; Etiology; expectation; Foundations; Future; Generations; Genetic Transcription; Glucose; glucose metabolism; Hexosamines; Human; immune activation; Immune Cell Activation; Immune signaling; Immune system; in vivo; Individual; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; Innate Immune Response; Interleukin-10; Intervention; Knowledge; Link; Lysine; Malignant Neoplasms; MAP Kinase Gene; Mass Spectrum Analysis; Mediating; Metabolic; Metabolism; Modeling; Molecular; Molecular Target; Mus; Myelogenous; Myeloid Cells; Nebraska; novel; Nuclear; O-GlcNAc transferase; Pathway interactions; Patients; Persons; Phosphorylation; Play; Post-Translational Protein Processing; Process; Production; Proteins; Regulation; Role; Severity of illness; Signal Pathway; Signal Transduction; Site; Site-Directed Mutagenesis; Stat3 protein; System; Testing; Tissues; TNF receptor-associated factor 6; transcription factor; treatment strategy; tumor growth; tumorigenesis; ubiquitin-protein ligase; Ubiquitination; Ulcerative Colitis; United States; Uridine Diphosphate N-Acetylglucosamine; Validation; Work; ","Role of O-GlcNAc Transferase-Mediated Innate Immune Response in Colonic Inflammation and Tumorigenesis","121316","ZGM1","Special Emphasis Panel ","8788","","02","183000","96075","","279075"
"9672443","P30","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P30ES009089","","RFA-ES-17-003","5P30ES009089-21","NIEHS:362848\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","NEW YORK","UNITED STATES","","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","","1883866; ","SANTELLA, REGINA M;","","","","Academic Medical Centers; Aliquot; analytical method; Archives; biobank; Bioinformatics; Biological; Biological Assay; Biological Markers; Biometry; Blood; Cardiovascular Diseases; career development; Collaborations; Collection; Communities; Comprehensive Cancer Center; Consult; Consultations; Core Facility; cost; cost effective; Custom; Data; Data Analytics; design; Development; DNA; DNA Adducts; DNA Methylation; Doctor of Philosophy; Environmental Exposure; Environmental Health; Enzyme-Linked Immunosorbent Assay; epidemiology study; Faculty; Farming environment; Fostering; Freezing; Future; Goals; Hair; Health Sciences; Health Services Accessibility; Human; Human Resources; Individual; Instruction; Integrative Medicine; Interdisciplinary Study; Investigation; Laboratories; Libraries; Link; Logistics; Lung diseases; Malignant Neoplasms; Massive Parallel Sequencing; Measures; member; Metals; Methods; Molecular Epidemiology; Nail plate; National Institute of Environmental Health Sciences; nervous system disorder; novel; Output; Participant; Phase; Pilot Projects; Postdoctoral Fellow; Preparation; Protocols documentation; Public Health; Publications; Research; Research Design; Research Personnel; Research Project Grants; Resources; RNA; sample collection; Sampling; Sampling Studies; Science; Scientist; Services; Ships; Structure; student training; Students; System; Teacher Professional Development; Testing; Time; tool; Trace metal; Training; Universities; University resources; Untranslated RNA; Urine; Work; ","Integrative Health Sciences Facility Core","009089","EHS","Environmental Health Sciences Review Committee ","7563","","21","226780","136068","","362848"
"9672568","P01","HL","5","N","04/26/2019","04/01/2019","03/31/2020","","P01HL136267","","PAR-13-316","5P01HL136267-03","NHLBI:699907\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BIRMINGHAM","UNITED STATES","","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","ANIMAL AND ANALYTICAL CORE (B) NARRATIVE The Program Project focuses on elucidating mechanisms by which the kidney controls sodium excretion and blood pressure, and therefore, has direct relevance to the serious health problem of salt-dependent hypertension and kidney disease. The Animal and Analytical Core will be critical for providing quality control for all animal studies ensuring that the appropriate animal models are available to the individual projects in sufficient quantities.","6225753; ","KOHAN, DONALD E;","MARIC-BILKAN, CHRISTINE","","","Alabama; Alleles; Animal Model; Animals; ARNTL gene; Biological Assay; Blood Pressure; Blood Vessels; Breeding; Cells; Coordination and Collaboration; Duct (organ) structure; Ductal Epithelial Cell; Endothelial Cells; Endothelin-1; Ensure; Excretory function; experience; experimental study; Gene Targeting; Genotype; Goals; HDAC1 gene; Health; Health Sciences; Hypertension; Individual; Institutes; Joints; Kidney; kidney cell; Kidney Diseases; Knock-out; Knockout Mice; Location; LoxP-flanked allele; Monitor; Mus; NOS1 gene; NOS3 gene; novel; operation; PKD2 protein; polycystic kidney disease 1 protein; Procedures; programs; Proprotein Convertase 1; Quality Control; Rattus; Reagent; receptor; Records; Research; Rodent; Rodent Model; Services; Shipping; Site; Sodium; Sodium Chloride; Structure; symposium; Tail; Texas; Transgenic Animals; Transgenic Organisms; United States National Institutes of Health; Universities; Utah; Vascular Endothelial Cell; ","Animal and Analytical Core","136267","HLBP","Heart, Lung, and Blood Initial Review Group ","8214","","03","581015","118892","","699907"
"9672572","P01","HL","5","N","04/26/2019","04/01/2019","03/31/2020","","P01HL136267","","PAR-13-316","5P01HL136267-03","NHLBI:540763\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BIRMINGHAM","UNITED STATES","","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","PROJECT 3 NARRATIVE High sodium consumption contributes to vast numbers of cardiovascular-related deaths. Dysfunctional sodium excretion results in salt-sensitive hypertension. Our innovative data shows that high salt diet induces the enzyme, histone deacetylase, in the renal collecting duct to maintain normal sodium excretion and blood pressure control. We also found that histone deacetylase regulates the pro-natriuretic activation of endothelin- 1 expression as well as the activation of nitric oxide synthase in the collecting duct. The main goals of this proposal are to elucidate the mechanisms critical for salt-dependent activation of histone deacetylase and the pro-natriuretic factors to provide in-depth understanding of the physiological contribution of these mechanisms on sodium excretion and maintenance of blood pressure control.","1875620; ","POLLOCK, JENNIFER S;","MARIC-BILKAN, CHRISTINE","","","Acetylation; Blood Pressure; blood pressure regulation; Cardiovascular system; Cell Nucleus; Cells; Cessation of life; Chronic; circadian; Consumption; Data; Deacetylation; Duct (organ) structure; Endothelin; Endothelin-1; Enzymes; Epigenetic Process; epithelial Na+ channel; Excretory function; Exposure to; Feedback; Genes; Genetic Transcription; Goals; HDAC1 gene; high salt diet; Histone Deacetylase; Histone Deacetylase Inhibitor; Histone Deacetylation; Homeostasis; Infusion procedures; inhibitor/antagonist; innovation; Kidney; Lysine; Maintenance; Mediating; member; Molecular; mRNA Expression; Mus; Natriuresis; Natriuretic Factors; Nitric Oxide; Nitric Oxide Synthase; NOS1 gene; NOS3 gene; novel; Nuclear; overexpression; Pathway interactions; Physiological; prevent; Production; Protein Dephosphorylation; Protein Isoforms; Protein phosphatase; Proteins; Rattus; receptor expression; Regulation; Regulatory Pathway; Renal function; Reporting; salt intake; salt sensitive hypertension; saluretic; Scheme; Signal Transduction; Sodium; Sodium Chloride; Testing; Transcriptional Regulation; Transport Process; Up-Regulation; urinary; ","HDAC-mediated regulation of endothelin and nitric oxide","136267","HLBP","Heart, Lung, and Blood Initial Review Group ","8217","","03","409599","131164","","540763"
"9672927","U19","AI","5","N","04/25/2019","04/01/2019","03/31/2020","","U19AI089688","","RFA-AI-15-056","5U19AI089688-10","NIAID:464833\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","The Malaria Evolution in South Asia International Center of Excellence for Malaria  Research (MESA-ICEMR) will study the changing nature of malaria parasites in India. We  are particularly interested in initiation of drug resistance as well as the pathways and  ecological barriers to dissemination of such traits. Teams at unique sites spanning India  will study malaria parasites in human hosts, mosquito vectors, and controlled laboratory  studies after adaptation to answer these questions.","6074776; ","RATHOD, PRADIPSINH K.;","","","","Africa; Age; Antimalarials; Appearance; Artemisinins; Asia; Bangladesh; base; Biological Assay; Cambodia; Cells; Cessation of life; Characteristics; Clinical; Clinical Research; Clinics and Hospitals; cohort; Combined Modality Therapy; Communities; Community Surveys; Country; Culicidae; Data; Development; Disease; Dissection; Documentation; Drug resistance; Drug usage; Ecology; Environment; Epidemic; Epidemiology; Erythrocytes; Evolution; Exposure to; Far East; Genotype; Gland; Government; Human; human disease; Immunity; India; Individual; Infection; Institutes; interest; international center; Laboratory Study; Laos; Lead; Location; Malaria; Measures; Medical Research; Methods; Microscopy; molecular marker; Monitor; Morbidity - disease rate; mortality; Mutation; Myanmar; Nature; novel; novel therapeutics; Outcome; Parasite resistance; Parasites; Pathology; Pathway interactions; Patients; Pattern; Pharmaceutical Preparations; Phenotype; phenotypic biomarker; Plasmodium; Plasmodium falciparum; Plasmodium vivax; product development; Prognostic Marker; Program Development; programs; Publishing; Reporting; Research; Resistance; response; Risk Factors; Sampling; Scientist; Shapes; Site; Southeastern Asia; Testing; Time; trait; transmission process; urban area; Variant; vector; vector mosquito; Virulent; Work; ","Project A","089688","ZAI1","Special Emphasis Panel ","5498","","10","412160","94617","","464833"
"9672929","U19","AI","5","N","04/25/2019","04/01/2019","03/31/2020","","U19AI089688","","RFA-AI-15-056","5U19AI089688-10","NIAID:373156\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","The Malaria Evolution in South Asia International Center of Excellence for Malaria  Research (MESA-ICEMR) will study the changing nature of malaria parasites in India. We  are particularly interested in initiation of drug resistance as well as the pathways and  ecological barriers to dissemination of such traits. Teams at unique sites spanning India  will study malaria parasites in human hosts, mosquito vectors, and controlled laboratory  studies after adaptation to answer these questions.","7624517; ","DURAISINGH, MANOJ T;","","","","Adhesions; Adult; Africa; age group; Antibodies; Antigens; Asia; Binding; Biological Assay; Biological Markers; Biomass; Blood; burden of illness; Cell physiology; Cells; Cerebral Malaria; Characteristics; Child; Clinical; clinical phenotype; Clinical Research; Community Surveys; Culicidae; density; Diagnostic; Disease; Dissection; Drug resistance; Drug usage; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Epidemiology; Epigenetic Process; Erythrocytes; Evaluation; Evolution; Gene Expression; Genetic Polymorphism; Genetic Transcription; Genotype; Geographic Locations; Government; Human; human disease; Immunity; In Vitro; India; Infection; interest; international center; Kidney; Laboratory Study; Lactate Dehydrogenase; Lead; Ligands; Link; Liver; Lung; Malaria; Measures; Mediating; Modeling; Molecular; Morbidity - disease rate; mortality; Mutation; Nature; neglect; novel; Organ; Outcome; Parasitemia; Parasites; Pathogenesis; Pathology; Pathway interactions; Patients; Pattern; Pharmaceutical Preparations; Phenotype; Plasma; Plasmodium falciparum; Plasmodium vivax; Predisposition; preference; product development; profiles in patients; Program Development; Property; Quantitative Reverse Transcriptase PCR; receptor; Recombinants; Research; Resistance profile; response; Reticulocytes; Scientist; Serum; Severities; Severity of illness; Shapes; Site; Southeastern Asia; Symptoms; Systemic infection; Testing; trait; transcriptome sequencing; transmission process; Tropism; urban area; vaccine candidate; vaccine development; Vaccines; Variant; vector; vector mosquito; Work; ","Project C","089688","ZAI1","Special Emphasis Panel ","5500","","10","415100","0","","373156"
"9673215","K23","HL","5","N","04/26/2019","04/01/2019","03/31/2020","233","K23HL138155","","PA-16-198","5K23HL138155-02","NHLBI:167832\","OTHER RESEARCH-RELATED","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","SEATTLE","UNITED STATES","","07","048682157","US","1531401","SEATTLE CHILDREN'S HOSPITAL","WA","981053901","PROJECT NARRATIVE Children surviving critical illness have profound long term health and quality of life impairments. The goal of this research program is to characterize the role of persistent sleep deficiency on long term health outcomes following critical illness in children. This information will be used to develop intervention strategies to improve outcomes following critical illness.","11677721; ","GROENEWALD, CORNELIUS BOTHA;","BROWN, MARISHKA","04/01/2018","03/31/2023","actigraphy; Active Learning; Acute; Address; Adult; Age; Anesthesiology; awake; Award; career development; Child; Childhood; Circadian Rhythms; Clinical Trials; Critical Illness; Critically ill children; Data; depressive symptoms; digital; experience; falls; flexibility; Geography; Goals; Grant; Health; health care service utilization; health service use; Healthcare; Impaired health; Impairment; improved; improved outcome; Intensive Care Units; Intervention; Intervention Studies; Interview; Knowledge; Lead; Measures; Medicine; Mental Health; Mentors; Mentorship; Monitor; Nature; Observational Study; Outcome; Pain; pain symptom; Parents; Patients; Pattern; Pediatric Hospitals; Pediatric Intensive Care Units; physical conditioning; Physiology; pilot trial; Play; professor; programs; Prospective cohort study; Qualitative Research; Quality of life; Recovery; Reporting; Research; Research Design; Research Methodology; Research Project Grants; Risk Factors; Role; Self Management; sex; skills; Sleep; Sleep Deprivation; Sleep disturbances; sleep health; sleep quality; Sleeplessness; Statistical Methods; Stream; Structure; Survivors; Technology; Testing; Time; Training; United States; Universities; Washington; Writing; ","Sleep Disturbances and Long-term Outcomes after Critical Illness in Children","138155","MPOR","NHLBI Mentored Patient-Oriented Research Review Committee ","","","02","155400","12432","167832",""
"9676317","P30","ES","5","N","04/26/2019","04/01/2019","03/31/2020","","P30ES027792","","RFA-ES-16-001","5P30ES027792-03","NIEHS:340140\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","CHICAGO","UNITED STATES","","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","","2100156; ","AHSAN, HABIBUL ;","","","","Address; Area; Automobile Driving; Biological Markers; career development; Chicago; Cities; Clinical; Clinical and Translational Science Awards; Collaborations; Communication; Communities; Community Healthcare; Community Outreach; Core Facility; Databases; Education; Educational workshop; Ensure; Environment; Environmental Health; Environmental Risk Factor; ethnic health disparity; Exposure to; Faculty Recruitment; Focus Groups; Grant; Group Meetings; Health; Health Personnel; health science research; Health Sciences; Human Resources; improved; Infrastructure; Integrative Medicine; inter-institutional; International; Lead; Leadership; Marketing; meetings; member; Mission; Modeling; Monitor; Multimedia; National Institute of Environmental Health Sciences; operation; Outcome; Participant; Pilot Projects; Program Development; programs; Progress Reports; Public Health; Publications; racial and ethnic; Recommendation; Records; recruit; Reporting; Research; Research Activity; Research Personnel; Resources; response; Series; Services; social media; statistics; success; System; Targeted Research; Time; tool; Translational Research; Universities; University resources; Vision; web site; Work; ","CACHET: Administrative Core","027792","ZES1","Special Emphasis Panel ","7102","","03","255813","84327","","340140"
"9679246","R01","HD","5","N","04/25/2019","04/01/2019","03/31/2020","865","R01HD090138","SCHOOLS OF MEDICINE","PA-16-160","5R01HD090138-03","NICHD:521418\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","LOS ANGELES","UNITED STATES","NONE","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","Project Narrative We propose to investigate whether a well-validated behavioral intervention (JASPER: Joint Attention, Symbolic Play, Engagement, Regulation) can improve social communication skills, face processing, and resting state brain activity in infants with Tuberous Sclerosis Complex, a genetic syndrome that confers a high risk for neurodevelopmental disorders such as autism spectrum disorders (ASD). We couple behavioral measures with electrophysiological (EEG) biomarkers in order to capture subtle changes in brain development that may reflect responses to treatment prior to an overt behavioral change, and to inform the neural mechanisms underlying the behavioral change found with intervention.","10521132; ","JESTE, SHAFALI SPURLING;","KING, TRACY","07/01/2017","03/31/2022","Address; Affect; Aftercare; Age; Attenuated; autism spectrum disorder; Autistic Disorder; Behavior; behavior change; behavior measurement; Behavior Therapy; Behavioral; behavioral outcome; Biological Markers; body system; Boston; Brain; Caring; Child; Clinical; Clinical Trials; Cognition; Cognitive; cognitive neuroscience; Collaborations; comparison group; Control Groups; design; Development; Developmental Delay Disorders; Developmental Disabilities; Diagnosis; Early identification; Early Intervention; Electrophysiology (science); Enrollment; Event; Face; Face Processing; Genetic; Genetic Diseases; Goals; group intervention; Growth; high risk; improved; Infant; Intellectual functioning disability; Interdisciplinary Study; Intervention; intervention effect; Intervention Studies; joint attention; Joints; Language; Lead; Life; Maintenance; Measures; Mediating; Methodology; Mission; Modification; National Institute of Child Health and Human Development; Neurodevelopmental Disability; Neurodevelopmental Disorder; neuromechanism; Non-Malignant; Outcome; Outcome Measure; Parents; Pediatric Hospitals; Play; Prenatal Diagnosis; prevent; Process; Prospective Studies; Randomized; recruit; Regulation; relating to nervous system; Research; response; Rest; Site; skills; social communication; Social Development; specific biomarkers; Symptoms; Syndrome; Time; Translational Research; treatment effect; treatment response; Tuberous sclerosis protein complex; visual processing; Waiting Lists; ","Mechanisms of change with early intervention in Tuberous Sclerosis Complex","090138","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","","03","406313","115105","521418",""
"9686792","R01","NS","5","N","04/24/2019","04/01/2019","03/31/2020","853","R01NS092033","SCHOOLS OF MEDICINE","PA-13-302","5R01NS092033-05","NINDS:446105\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","CLEVELAND","UNITED STATES","OTHER BASIC SCIENCES","11","135781701","US","10000858","CLEVELAND CLINIC LERNER COM-CWRU","OH","441950001","PUBLIC HEALTH RELEVANCE: Effective delivery of neuronal Protective Nanoparticles (Pro-NPs), loaded with antioxidant enzymes, to the lesion site following spinal cord injury (SCI) could potentially mitigate the reactive oxygen species (ROS) - mediated cascade of degenerative events and facilitate endogenous repair mechanisms. At present, there is no effective treatment that can achieve functional recovery following traumatic SCI. Our therapy, based on effective and sustained antioxidant delivery to the injured spinal cord, can potentially offer a safe and effective treatment that can benefit patients with acute SCI.","1867120; ","LABHASETWAR, VINOD D;","JAKEMAN, LYN B","04/01/2015","03/31/2020","Acute; Address; Affect; Aftercare; Anatomy; Animal Model; Animals; antioxidant enzyme; Antioxidants; base; Bladder; Blood; Caring; catalase; Cells; chemokine; Chest; Clinical; clinically relevant; Control Animal; cost; cytokine; cytotoxic; Demyelinations; Deposition; design; disability; Dose; Drug usage; effective therapy; Electromyography; Encapsulated; Ensure; Environment; Enzymes; Event; Extravasation; Family Caregiver; FDA approved; Functional disorder; Generations; Genes; global health; Goals; Histologic; improved; Inflammatory; injured; Injury; intravenous administration; kinematics; Lesion; Leukocytes; Locomotor Recovery; macrophage; mechanical allodynia; Mediating; Methylprednisolone; Microglia; Modeling; Molecular; Molecular Weight; Morbidity - disease rate; mortality; Muscular Atrophy; nanoparticle; nanoparticle delivery; Natural regeneration; Nature; neurogenesis; Neurologic; neuron apoptosis; neuron loss; Neurons; neurophysiology; neuroprotection; neutrophil; Oligodendroglia; oxidative damage; Oxidative Stress; Paralysed; Paraplegia; Patients; Perception; Physiological; Plasticizers; Play; Polymers; Population; preclinical efficacy; public health relevance; Rattus; Reactive Oxygen Species; Recovery; Recovery of Function; repaired; response; Role; Secondary to; Sensory; Site; socioeconomics; Spinal; Spinal Cord; Spinal cord injury; Spinal cord injury patients; Stem cells; Superoxide Dismutase; Syringomyelia; Testing; Therapeutic; Therapeutic Intervention; Thermal Hyperalgesias; Time; Tissues; Toxic effect; Traumatic CNS injury; uptake; Wound Healing; ","Neuronal Protective Nanoparticles for Treating Acute SCI","092033","NANO","Nanotechnology Study Section ","","","05","281454","164651","446105",""
"9687720","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:221222\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","PROJECT 1: PROJECT NARRATIVE Arsenic is ranked #1 on the Superfund priority list of hazardous substances, and although its link to lung and bladder cancer is well established, its links to prevalent endocrine-related diseases like diabetes, hypertension, or prostate cancer are less clear. We propose to study these issues, and potential susceptibility due to exposomic factors like obesity, early-life exposure, and stress, using a one-of-a-kind cohort in northern Chile with lifelong data on arsenic exposure.","6710257; ","STEINMAUS, CRAIG M;","","","","Acute myocardial infarction; Address; Adult; Affect; Animals; Anxiety; Area; Arsenic; biological adaptation to stress; Biological Markers; Blood Pressure; Blood specimen; Cardiovascular Diseases; Case-Control Studies; Chemical Exposure; Chemicals; Chile; Chronic Kidney Failure; Cities; cohort; Communities; Data; design; Diabetes Mellitus; Diagnosis; Diet; Disease; disease mechanisms study; disorder risk; drinking; drinking water; early life exposure; Endocrine; Endocrine System Diseases; Environment; environmental stressor; Environmental Tobacco Smoke; Epidemiology; Ethnic Origin; Exposure to; fatty acid metabolism; Genetic; Glucocorticoids; Glycosylated hemoglobin A; Goals; Gonadal Steroid Hormones; Habits; Hazardous Substances; Health; Hormones; Hypertension; improved; In Vitro; Incidence; indexing; Individual; insight; Investigation; Lead; Life; lifestyle factors; Link; Long-Term Effects; low socioeconomic status; Lung diseases; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Malignant neoplasm of urinary bladder; Malignant Neoplasms; Mental Depression; Metabolic Pathway; Metabolism; Minority; Molecular; Morbidity - disease rate; mortality; Municipalities; Neurological outcome; Non-Insulin-Dependent Diabetes Mellitus; novel; Obesity; Odds Ratio; Outcome; Overweight; Persons; Pharmaceutical Preparations; Physicians; Planet Earth; Plants; Play; Poisons; Policies; Population; Predisposition; Prevalence; Records; Regulation; Renal Cell Carcinoma; Research; Research Support; respiratory; Risk; Risk Assessment; Risk Factors; Rivers; Role; Rural Community; Sampling; Serum; sex; Signal Recognition Particle; Smoking; social; Source; Stress; Superfund; superfund chemical; synergism; Taiwan; Toxic effect; Tuberculosis; tumor; Uterine Cancer; Water; water quality; Workplace; ","Project 1: Exposomics and Arsenic Epidemiology","004705","ZES1","Special Emphasis Panel ","5068","","31","184274","36948","","221222"
"9687730","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:76605\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","","9020883; ","ZHANG, LUOPING ;","","","","Address; Adopted; Aromatic Polycyclic Hydrocarbons; Arsenic; Benzene; California; Chemical Exposure; Chemicals; Chromium; Collaborations; Communities; community living; Complex; Consultations; contaminated drinking water; Data Science; Detection; Disease; early life exposure; Engineering; Environment; Environment and Public Health; Environmental Exposure; environmental stressor; Evaluation; Exposure to; Face; Formaldehyde; Goals; Hazard Identification; Hazardous Substances; Hazardous Waste Sites; Health; Human; improved; Laboratories; meetings; Methods; multidisciplinary; next generation; non-genetic; novel strategies; Obesity; Pathway interactions; Poisons; Population; Prevention; programs; remediation; Research; Research Personnel; Risk; Risk Assessment; Site; social; Stress; stressor; Superfund; superfund site; Techniques; tool; Toxic effect; Training; Translational Research; Translations; Trichloroethylene; ","Core-005-Training","004705","ZES1","Special Emphasis Panel ","5797","","31","70983","5622","","76605"
"9697809","R01","DK","5","N","04/25/2019","04/01/2019","03/31/2020","847","R01DK070888","EARTH SCIENCES/RESOURCES","PA-16-160","5R01DK070888-11","NIDDK:327555\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","MADISON","UNITED STATES","NUTRITION","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","Project Narrative Pancreatitis and pancreatic cancer are the two major diseases of the exocrine pancreas that afflict over 48,000 Americans each year with high mortality rates. The experiments outlined in this proposal will provide a mechanistic understanding of how dysregulation of pancreatic acinar cell homeostasis leads to the development of pancreatitis. These studies are essential to identify important cellular targets that may be therapeutically manipulated to treat pancreatic disease.","1901111; ","GROBLEWSKI, GUY E;","SERRANO, JOSE","06/01/2018","03/31/2022","Acinar Cell; acute pancreatitis; Admission activity; Adult; American; Animals; Apical; Attention; Automobile Driving; Autophagocytosis; Binding; Biology; body system; Cell model; Cell physiology; cell type; cellular targeting; chemokine; Critical Pathways; Crohn's disease; cytokine; Data; Development; Disease; Down-Regulation; economic impact; Elastases; Enzyme Precursors; Enzymes; Event; Exocrine pancreas; experimental study; genetic regulatory protein; Gland; Goblet Cells; Grant; Homeostasis; Hospitals; Human; Impairment; in vivo; Inflammatory Response; insight; Intestines; Knock-out; Knockout Mice; late endosome; Link; Lysosomes; Maintenance; Malignant neoplasm of pancreas; Maps; Mediating; Morphology; mortality; Mucous body substance; Mus; Mutate; Mutation; Palliative Care; Pancreas; Pancreatic Diseases; Pancreatitis; Paneth Cells; Pathologic; Pathway interactions; Pharmacologic Substance; Physiological; Play; Point Mutation; Preparation; prevent; Process; Proteins; Publishing; Recovery; Regulation; Regulatory Pathway; Reporting; response; RNA Splicing; Rodent; Role; Secretory Vesicles; Series; Shapes; Site; Slice; System; Tamoxifen; Testing; Therapeutic; therapeutic target; TPD52 gene; trafficking; trait; transcription factor; Trypsinogen; tumor; vesicle-associated membrane protein; Zymogen Granules; ","Acinar Biology and Pancreatic Disease","070888","CIMG","Clinical, Integrative and Molecular Gastroenterology Study Section ","","","11","225000","102555","327555",""
"9700673","P41","EB","5","N","04/26/2019","03/01/2019","02/29/2020","","P41EB015922","","PAR-17-083","5P41EB015922-22","NIBIB:278914\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","Los Angeles","UNITED STATES","","34","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PROJECT NARRATIVE - TR&D2: DIFFUSION MRI AND CONNECTOMICS The vast power of diffusion MRI has led to a revolution in neuroscience as the main fiber pathways in the brain can be mapped and evaluated. But without better tools, the tracts traced are prone to errors and the networks that result depend arbitrarily on choices made during the analysis. Our new algorithms attack key problems in analyzing brain microstructure, fiber tracts, and brain networks, adapting to exploit the better information content of cutting-edge diffusion MRI and vast amounts of older legacy data.","6111760; ","THOMPSON, PAUL M;","","","","Address; Adolescent; Affect; Algorithms; Anatomy; Anisotropy; Area; Atlases; base; biophysical model; Brain; Brain Diseases; Brain region; brain tissue; Child; Clinical Research; Collaborations; connectome; Data; Data Set; deep learning; Dementia; density; Detection; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Elderly; Fiber; Frontotemporal Dementia; Goals; Head; high dimensionality; HIV; Image; improved; innovation; Intervention; Label; Laboratories; Learning; learning strategy; Longevity; Machine Learning; Manuals; Maps; Mathematics; Measures; Medicine; Mental Depression; Mental disorders; Methods; mild traumatic brain injury; Minnesota; Modeling; MRI Scans; Nerve Degeneration; neuroimaging; neuropsychiatric disorder; Neurosciences; novel; novel strategies; Paper; Pathway Analysis; Pathway interactions; Patients; Pattern; Population; Post-Traumatic Stress Disorders; Presenile Alzheimer Dementia; Property; Publishing; Reproducibility; Research Personnel; Resources; Risk; Running; Scanning; Site; Skeleton; spectrograph; statistics; Students; Testing; Thailand; tool; tractography; ultra high resolution; white matter; Work; ","TR&D2: Diffusion MRI and Connectomics","015922","ZEB1","Special Emphasis Panel ","5229","","22","169039","109875","","278914"
"9700676","P41","EB","5","N","04/26/2019","03/01/2019","02/29/2020","","P41EB015922","","PAR-17-083","5P41EB015922-22","NIBIB:190821\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","Los Angeles","UNITED STATES","","34","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PROJECT NARRATIVE - TRAINING AND DISSEMINATION The intention of training and dissemination under LONIR is to provide a complete battery of the materials needed to educate investigators both on the theory and philosophy of image analysis, computational anatomy and multidimensional modeling, as well as the specific applications of software developed as part of the LONI P41 Resource.","6784208; ","VAN HORN, JOHN DARRELL;","","","","Adoption; animation; Award; base; Brain; Brain imaging; Caliber; CD-ROM; Collaborations; Communities; computational anatomy; Computer software; computerized data processing; Data; Data Science; Databases; Educational workshop; Ensure; experimental study; Faculty; Fellowship; Goals; Graduate Degree; Image; Image Analysis; imprint; indexing; Informatics; Information Dissemination; Instruction; Intention; interest; International; Internet; Laboratories; lecturer; lectures; Medial; meetings; Methodology; Methods; Modeling; neuroimaging; neuroinformatics; novel; online resource; Online Systems; Outcomes Research; Paper; Peer Review; Philosophy; Play; post-doctoral training; Postdoctoral Fellow; posters; program dissemination; programs; Protocols documentation; Publications; Recording of previous events; Research; Research Personnel; Resources; Series; Services; social media; software development; Software Tools; Students; symposium; Technology; theories; tool; Training; Training Programs; Universities; user-friendly; Visit; visiting scholar; web portal; web site; Work; ","Training and Dissemination","015922","ZEB1","Special Emphasis Panel ","5231","","22","115649","75172","","190821"
"9701961","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:155983\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","","1895266; ","GOODYEAR, LAURIE J;","","","","animal facility; animal imaging; Animal Model; Animals; Area; base; Biometry; Blood flow; Blood Glucose; Blood Pressure; Body Composition; Body Temperature; Cells; Cellular Metabolic Process; clinical investigation; Consult; Controlled Study; cost; Data Collection; Development; Diabetes Mellitus; Diabetic mouse; Disease Progression; Dual-Energy X-Ray Absorptiometry; Electrocardiogram; Electroencephalography; Energy Metabolism; Equipment; Evaluation; Exercise; Exposure to; Funding; Gene Expression Profile; Genetic; Genetically Engineered Mouse; Genomics; Germ-Free; Goals; Hand Strength; Human Resources; Hyperoxia; Hypoxia; Imaging technology; in vivo; in vivo imaging system; Incubators; Insulin Resistance; investigator training; Journals; Laboratories; Lasers; Maintenance; Measurement; Metabolic Diseases; Metabolism; meter; microbiome; microscopic imaging; Monitor; Mus; muscle strength; Nature; novel; Obesity; optical imaging; Paper; perfusion imaging; Physiological; Physiology; Procedures; Publications; Rattus; Reporter; Research; Research Design; Research Personnel; Rodent; Role; Services; System; Tail; Telemetry; Temperature; Tissues; trafficking; Training; treadmill; ","Animal Physiology Core","036836","ZDK1","Special Emphasis Panel ","7091","","33","92434","63549","","155983"
"9702793","P30","DK","5","N","04/24/2019","04/01/2019","03/31/2020","","P30DK057521","","RFA-DK-13-004","5P30DK057521-20","NIDDK:267960\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","","1955860; ","KAHN, BARBARA B.;","","","","Animals; Area; Biological; blood glucose regulation; Body Composition; Boston; Consultations; Data Analyses; design; Diabetes Mellitus; Educational process of instructing; Endocrinology; energy balance; Ensure; Experimental Designs; gene product; Genetic Vectors; Genomics; Hormones; In Vitro; in vivo; Insulin; Insulin Resistance; insulin sensitivity; knockout gene; Leptin; lipid metabolism; member; Metabolic; metabolomics; Methods; Modeling; mouse model; Mus; Obesity; overexpression; Pathway interactions; Performance; Physiology; Proteomics; Rattus; Research; Research Personnel; Rodent Model; Role; Techniques; Technology; Viral Vector; ","Animal Metabolic Physiology Core","057521","ZDK1","Special Emphasis Panel ","7732","","20","267960","0","","267960"
"9710569","P30","AG","1","N","04/26/2019","04/01/2019","03/31/2020","","P30AG062422","","RFA-AG-19-001","1P30AG062422-01","NIA:437632\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","8777046; ","KAO, AIMEE ;","","","","accurate diagnosis; Aging; Alzheimer's Disease; Alzheimer's disease related dementia; Alzheimer's disease risk; Amyloid beta-Protein; base; Basic Science; Biochemistry; Biological Markers; biomarker development; biomarker discovery; Cell Culture Techniques; Cells; Clinical; Clinical Research; Collaborations; Collection; Communities; Data; data management; Data Storage and Retrieval; data submission; Dementia; Dermal; Development; Disease; disease heterogeneity; DNA; Doctor of Philosophy; Early Diagnosis; Education; Epithelial; exome sequencing; experience; Fibroblasts; Foundations; Functional disorder; Future; Generations; Genetic; Genetic Markers; genome-wide; genomic biomarker; Genomics; Genotype; Goals; Heterogeneity; Human; Human Genetics; Image; improved; induced pluripotent stem cell; Infrastructure; innovation; insight; interest; International; Investigation; Learning; Light; Liquid substance; Measurement; Measures; Mentors; Mission; Molecular Genetics; Monitor; multidisciplinary; Neurodegenerative Disorders; neurofilament; neuroimaging; neuroimaging marker; Neurologist; neuropathology; novel; novel strategies; Online Systems; Participant; Patients; Physicians; Pilot Projects; Plasma; Positioning Attribute; Privatization; Procedures; proteostasis; recruit; repository; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Estimate; risk variant; Sampling; Scientist; specific biomarkers; Specimen; Standardization; success; tau Proteins; tau-1; Techniques; therapy development; tool; Training; Translational Research; Variant; Work; ","Core G: Biomarker Core","062422","ZAG1","Special Emphasis Panel ","5039","","01","321404","116228","","437632"
"9722456","R01","CA","1","N","04/22/2019","04/22/2019","03/31/2020","393","R01CA229355","","PAR-18-675","1R01CA229355-01A1","NCI:535708\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","CAMBRIDGE","UNITED STATES","","07","805262995","US","4214601","CAMBRIDGE HEALTH ALLIANCE","MA","021391047","Project Narrative Higher sustained tobacco use among smokers with substance use disorder (SUD) is associated with significantly higher mortality rates than non-smokers with SUD and the general population, and is attributed to: higher nicotine dependence, reinforcing and synergistic effects of concurrent substance use, and poor access to effective tobacco dependence treatment (TDT). We propose to assess the impact of expanded coverage of TDT in Medicaid as well as tobacco excise taxes on use of TDT services, smoking intensity, and quit rates for smokers with SUD; we further propose to assess the combined effect of Medicaid coverage of TDT alongside excise taxes on these outcomes. We have worked closely with stakeholders to propose analyses that inform decision-makers in complex real- world policy environments with hard-to-reach populations, and we incorporate a dissemination strategy that will lay the groundwork for actionable policy changes in health care and regulatory, environments by targeting state tobacco control managers, individual state agencies for SUD services, SUD treatment providers reluctant to incorporate tobacco cessation, and integrated behavioral health providers.","8921241; ","COOK, BENJAMIN LE;","VOLLINGER, ROBERT","04/22/2019","03/31/2023","Address; Adherence; Affect; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Antismoking; Behavior; behavioral health; beneficiary; Caring; Cessation of life; Chantix; Cigarette; Cities; Clinical; Complex; Counseling; County; Data; Data Set; demographics; Dependence; Disease; Drug Prescriptions; Drug usage; Effectiveness; Enrollment; Environment; evidence base; General Population; group counseling; Health; Health Care Reform; Health Personnel; Healthcare; heroin use; High Prevalence; High-Risk Cancer; illicit drug use; Illicit Drugs; improved; Incentives; Individual; Insurance Carriers; Insurance Coverage; Joints; Low income; Low Income Population; low socioeconomic status; Maintenance; Malignant Neoplasms; Measures; Medicaid; Mental disorders; Methods; Modeling; mortality; Nicotine Dependence; nicotine replacement; non-smoker; Outcome; Pharmaceutical Preparations; Policies; Population; Prevalence; Price; public policy on tobacco; Regulation; Reporting; Research; Sampling; Services; Smoker; Smoking; smoking cessation; Source; Substance Use Disorder; Surveys; Taxation; Taxes; Testing; Time; Tobacco; tobacco control; Tobacco Dependence; Tobacco use; Tobacco Use Cessation; tobacco user; Translations; treatment center; Treatment outcome; treatment services; United States; Variant; Visit; Vulnerable Populations; Withdrawal Symptom; Work; Zyban; ","Impact of State Policies on Smoking among Individuals with Substance Use Disorder","229355","ZRG1","Special Emphasis Panel ","","A1","01","329289","206419","535708",""
"9729352","U19","AI","2","N","04/22/2019","04/25/2019","03/31/2020","","U19AI110818","","RFA-AI-18-004","2U19AI110818-06","NIAID:737829\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","","07","623544785","US","10021177","BROAD INSTITUTE, INC.","MA","021421027","","10159321; ","EARL, ASHLEE MIRIAM;","","","","Achievement; Antibiotic Resistance; Antibiotics; Bacterial Infections; Bioinformatics; Blood Circulation; carbapenem resistance; carbapenem-resistant Enterobacteriaceae; Cells; Clinical; Clinical Research; cohort; Collaborations; Collection; Colon; combat; Communicable Diseases; Communities; Complex; Computing Methodologies; Development; Diagnosis; Enterococcus; Environment; Epidemiologist; Frequencies; Genes; Genetic; Genome; Genomics; Goals; Habitats; Hospitals; Host Defense; host microbiota; Household; Human; improved; Individual; Infection; Infection Control; innovation; International; Intervention; Knowledge; Measures; Methods; microbiota; Molecular; Movement; Multi-Drug Resistance; multiple omics; new technology; Nosocomial Infections; novel; pathogen; pathogenic bacteria; Pathway interactions; Patients; Population; prevent; Prevention; Recording of previous events; Recurrence; Research Personnel; Resistance; resistance gene; resistant strain; Resources; Risk; Route; Sampling; Shapes; Source; success; surveillance strategy; Technology; Therapeutic; tool; transcriptome; transmission process; Travel; trend; Urinary tract; Urinary tract infection; Uropathogenic E. coli; Virulence; Woman; ","Project 2 Defining multiscale dynamics of strains, genes and resistance in bacterial pathogens","110818","ZAI1","Special Emphasis Panel ","5979","","06","456617","281212","","737829"
"9737526","R01","DK","2","N","04/26/2019","04/26/2019","03/31/2020","847","R01DK068196","SCHOOLS OF MEDICINE","PA-18-484","2R01DK068196-13A1","NIDDK:391250\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","PITTSBURGH","UNITED STATES","ANATOMY/CELL BIOLOGY","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","Narrative: This work examines the impact of SUMO modification on the biogenesis vs. degradation of the cystic fibrosis (CF) gene product, CFTR. Most CFTR mutations cause misfolding and premature degradation of the protein, preventing its trafficking to the apical membranes of epithelial cells. Understanding the ability of SUMO to increase CFTR biogenesis will enhance our knowledge of the CFTR folding pathway and support therapeutics development for CF.","1877276; ","FRIZZELL, RAYMOND A;","EGGERMAN, THOMAS L","07/01/2004","03/31/2024","Acetylation; Apical; apical membrane; Autophagocytosis; base; Behavior; Binding Proteins; Biochemical; Biogenesis; Biological Assay; Biology; Biophysics; bronchial epithelium; Cell membrane; Cell surface; Cells; Clinical; Clinical Research; Complex; Conflict (Psychology); Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Data; Deacetylase; Defect; Delta F508 mutation; density; Dependence; Disease; Endoplasmic Reticulum; Enzymes; Epithelial Cells; Facebook; Friends; gene product; Generations; HDAC6 gene; Heat shock proteins; Histone Deacetylase; Human; Integral Membrane Protein; Knowledge; Length; Ligation; Link; Mass Spectrum Analysis; Mediating; Mediator of activation protein; misfolded protein; Modification; Molecular Chaperones; Molecular Conformation; Mutagenesis; mutant; Mutation; novel; novel strategies; Outcome; paralogous gene; Pathway interactions; Peptide Hydrolases; Phenotype; Phosphorylation; Physiologic pulse; Play; premature; prevent; Production; protein aggregation; protein complex; protein degradation; protein folding; Protein-Folding Disease; Proteins; Proteolysis; proteostasis; Quality Control; rare variant; Recycling; Reporting; response; Role; Scheme; Site; small molecule; sumo1 gene; Sumoylation Pathway; Support System; System; therapeutic development; Thermodynamics; trafficking; Ubiquitin; ubiquitin ligase; ubiquitin-protein ligase; Variant; VX-809; Work; ","Chaperone Actions in CFTR Biogenesis","068196","LCMI","Lung Cellular, Molecular, and Immunobiology Study Section ","","A1","13","250000","141250","391250",""
"9739626","R01","AI","1","N","04/22/2019","04/22/2019","03/31/2020","855","R01AI140133","SCHOOLS OF MEDICINE","PA-18-484","1R01AI140133-01A1","NIAID:652468\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ANN ARBOR","UNITED STATES","PATHOLOGY","12","073133571","US","1506502","UNIVERSITY OF MICHIGAN AT ANN ARBOR","MI","481091276","Project Narrative Eosinophilic esophagitis (EoE) is increasing in prevalence, with rates as high as ~1/2,500 children, and is now the leading cause for proton-pump inhibitor (PPI)?resistant dysphagia and food impaction in adults. Though the medical and scientific communities have made significant advances in identifying that combined genetic and environmental factors influence susceptibility to EoE, the primary pathways involved in the onset of the clinical manifestations of the disease remain unknown. These studies will define whether dysregulation of the SLC9A3-dependent acid transport in the esophageal epithelium in EoE promotes its histopathologic and clinical manifestations and provide needed insight into the relationships between esophageal eosinophilia, acid and EoE, thereby directing development of new and pre-existing therapeutics for treating esophageal eosinophilia?related disorders.","8469412; ","HOGAN, SIMON PATRICK;","MINNICOZZI, MICHAEL","04/22/2019","03/31/2023","Acids; Adult; Allergic; Allergic inflammation; Animals; Aryl Hydrocarbon Receptor; aryl hydrocarbon receptor ligand; Automobile Driving; base; Biopsy; Biopsy Specimen; Calpain; CCL26 gene; Cells; Child; Chronic; Clinical; cohort; Communities; Coupled; cytokine; Data Set; Deglutition Disorders; desmoglein 1; Development; Diet; differential expression; Disease; Environmental Risk Factor; eosinophil; Eosinophilia; Eosinophilic Esophagitis; eosinophilic inflammation; Epithelial; Epithelial Cells; Epithelium; Esophageal; Esophageal Diseases; Esophagus; Extracellular Space; Family member; Food; food antigen; Functional disorder; Gastroesophageal reflux disease; gastrointestinal symptom; Gene Expression; Genes; Genetic; genetic profiling; Genetic Transcription; Histologic; Human; humanized mouse; Hyperplasia; Immune; Immunity; Individual; Inflammatory; Inflammatory Response; insight; Interleukin-13; Intervention; intraepithelial; Kininogenase; Mediating; Medical; Molecular; mRNA Expression; Ontology; Organoids; Outcome Study; Pathway interactions; patient subsets; Patients; Pharmacology; Predisposition; Prevalence; Process; protein expression; Proteins; Proton Pump Inhibitors; Protons; Receptor Signaling; Regulation; Regulator Genes; Resistance; RNA; RNA Interference; Serine Protease; Severity of illness; Signal Transduction; Sodium-Hydrogen Antiporter; Squamous Epithelium; Stratum Basale; System; Techniques; Technology; Testing; Therapeutic; Transcript; transcription factor; Transcriptional Regulation; transcriptome; transcriptome sequencing; Transplantation; ","SLC9A3 regulation of esophageal dilated intercellular spaces in EoE Subtypes","140133","ZRG1","Special Emphasis Panel ","","A1","01","476033","176435","652468",""
"9760230","F32","AT","1","N","04/10/2019","04/16/2019","04/15/2020","213","F32AT010087","GRADUATE SCHOOLS","PA-18-670","1F32AT010087-01A1","NCCIH:61610\","TRAINING, INDIVIDUAL","2019","National Center for Complementary & Integrative Health","","NEW YORK","UNITED STATES","BIOLOGY","12","071037113","US","7056601","ROCKEFELLER UNIVERSITY","NY","100656399","Project Narrative The enteric pathogen Clostridium difficile causes antibiotic-associated diarrhea and is one of the leading causes of gastroenteritis mortality. Secreted antigen A (SagA) from the commensal microbe Enterococcus faecium increases host immunity (in C. elegans and mouse models) against C. difficile infection. The proposed research will, 1) biochemically characterize SagA activity, 2) genetically insert the sagA gene into probiotic lactic acid bacteria, and 3) determine host protection in mice against C. difficile relapse infection models in order to eventually develop a safe probiotic therapeutic to prevent primary or relapse infection of C. difficile.","11176276; ","HESPEN, CHARLES W;","WANG, YISONG","04/16/2019","04/15/2022","Aftercare; Animals; Antibiotic Therapy; antibiotic-associated diarrhea; Antibiotics; Antigens; Bacteria; Bacterial Infections; base; Biochemical; Caenorhabditis elegans; Cell Wall; Chromosomal Insertion; Chromosomes; Civilization; Clostridium difficile; Colitis; commensal bacteria; commensal microbes; Communicable Diseases; design; Diarrhea; Engineered Probiotics; Engineering; Enteral; enteric pathogen; Enterococcus faecium; fecal transplantation; Future; Gastroenteritis; Genes; Goals; gut microbiota; Human; Hydrolase; Immunity; In Vitro; Infection; lactic acid bacteria; Length; Methods; Modeling; mortality; mouse model; Multiple Bacterial Drug Resistance; Mus; N-Acetylmuramoyl-L-alanine Amidase; novel therapeutics; pathogenic bacteria; Peptidoglycan; prevent; probiotic therapy; Probiotics; Recombinants; Recurrence; Relapse; Reproduction spores; Research; Structure; Therapeutic; Therapeutic Agents; Toxin; Universities; Work; ","Mechanistic analysis and engineering probiotic bacteria with SagA","010087","ZAT1","Special Emphasis Panel ","","A1","01","61610","","61610",""
"9771159","I01","VA","1","N","04/26/2019","04/01/2019","03/31/2020","999","I01BX004635","","RFA-BX-18-001","1I01BX004635-01","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","CHICAGO","UNITED STATES","","07","010299204","US","481026","JESSE BROWN VA MEDICAL CENTER","IL","606123728","Acute myeloid leukemia (AML) is a heterogeneous disease with variable prognosis. A subset of AML subjects with adverse outcomes are characterized by expression of a set of homeodomain transcription factors (HoxA7- 11, B3, B4 and Meis1). We used a murine model of this form of AML to identified pathways relevant to post- chemotherapy relapse using transcriptome and gene ontology analysis. The goal of the current studies is to use this information to identify rational therapeutic targets for translational approaches to relapse/drug resistance in human AML.","1898025; ","EKLUND, ELIZABETH ANN;","","04/01/2019","03/31/2023","11q23; Acute Myelocytic Leukemia; acute myeloid leukemia cell; adverse outcome; Alkylating Agents; Anabolism; Apoptotic; autocrine; biological adaptation to stress; Blocking Antibodies; Bone Marrow; Bone Marrow Cells; CD34 gene; Cells; chemotherapy; Chimeric Proteins; Chromosome abnormality; chromosome loss; Chromosomes, Human, Pair 7; Clinical; Comorbidity; Complex; CREBBP gene; Cytogenetics; cytokine; Cytokine Receptors; Cytokine Signaling; Cytotoxic Chemotherapy; design; Disease; Disease Progression; Disease remission; drug relapse; Drug resistance; Dysmyelopoietic Syndromes; Emergency Situation; Equilibrium; Event; Expression Profiling; Fas-associated phosphatase-1; FLT3 gene; Gene Activation; Gene Expression; Gene Targeting; Genes; Genetic Models; Glycosaminoglycans; Goals; Granulopoiesis; Growth Factor Receptors; Guanine Nucleotide Exchange Factors; Hematopoietic; homeodomain; HOX protein; HOXA10 gene; Human; Immune response; immunoregulation; Impairment; inhibitor/antagonist; Innate Immune Response; Integrin alphaV; Integrin beta3; Karyotype; knock-down; leukemia; leukemia stem cell; leukemogenesis; Mediating; MLL gene; Modeling; Molecular; mouse model; Mus; Mutation; Myelopoiesis; Myeloproliferative disease; neoplasm therapy; novel strategies; Ontology; Outcome; outcome forecast; overexpression; Oxidative Stress; Pathway interactions; Patients; Phagocytes; Phosphorylation; PIK3CG gene; Point Mutation; prevent; Process; Production; prognostic; Progressive Disease; protein expression; Protein Kinase; Protein phosphatase; Proteins; purine/pyrimidine metabolism; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Recurrent disease; Refractory Disease; Regulation; Relapse; Repression; Resistance; response; Role; Sampling; Signal Pathway; Signal Transduction; small molecule inhibitor; Stem Cell Leukemia; Stress; therapeutic target; Topoisomerase-II Inhibitor; TP53 gene; transcription factor; Transcriptional Activation; transcriptome; translational approach; ubiquitin-protein ligase; ","Molecular mechanisms of drug resistance and disease progression in acute myeloid leukemia","004635","ZRD1","Special Emphasis Panel ","","","01","","","",""
"9772827","R43","CA","1","N","04/22/2019","04/22/2019","10/31/2019","395","R43CA232808","","PA-18-574","1R43CA232808-01A1","NCI:299676\","SBIR-STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","NEW YORK","UNITED STATES","","10","831297770","US","10023522","NANOMETICS, LLC","NY","100145429","PROJECT NARRATIVE Lung cancer (LC) is the leading cause of cancer related deaths in the United States (U.S.) and worldwide. This Phase I SBIR proposal will demonstrate the feasibility of a novel small molecule Bax activator as an oral therapeutic for lung cancer.","12104305; ","MAHON, ANDREW B;","KURTZ, ANDREW J","04/22/2019","10/31/2019","A549; Accounting; Adopted; alpha helix; American Cancer Society; Amino Acids; Apoptosis; Apoptotic; base; BCL2 gene; Binding; Biological Sciences; Biotechnology; C-terminal; cancer cell; Cancer cell line; cancer diagnosis; Cancer Etiology; Cancer Patient; cancer therapy; care costs; Cell Death; Cells; Cessation of life; Clinical; Combined Modality Therapy; commercial application; Computer Simulation; cost; design; Development; Diagnosis; Disease Management; Disease model; Dose; Drug Kinetics; Engineering; Family member; Goals; Healthcare Systems; human model; improved outcome; In Vitro; in vivo; Induction of Apoptosis; intraperitoneal; Intraperitoneal Injections; Investigational New Drug Application; Knowledge; Lead; Malignant neoplasm of lung; Malignant Neoplasms; Mitochondria; Modeling; Molecular Conformation; mouse model; Mus; novel; novel therapeutics; Oral; Outcome; outcome forecast; Pathway interactions; Patient Care; patient population; Patient-Focused Outcomes; Pharmacology; Phase; phase 2 study; Phosphorylation; premature; Preparation; prevent; pro-apoptotic protein; Productivity; Property; protein activation; protein expression; Protein Family; Proteins; Resistance; response; Safety; screening; Serine; Small Business Innovation Research Grant; small molecule; Structure; success; technological innovation; Therapeutic; therapy resistant; Tissues; Toxic effect; Toxicokinetics; Treatment Efficacy; Treatment outcome; tumor growth; tumor progression; United States; United States National Institutes of Health; Universities; Xenograft Model; Xenograft procedure; ","A novel small molecule Bax activator as an oral therapeutic for the treatment of lung cancer.","232808","ZRG1","Special Emphasis Panel ","","A1","01","","","299676",""
"9869988","U01","DE","7","N","04/26/2019","02/01/2019","08/31/2019","121","U01DE027637","","PAR-15-059","7U01DE027637-02","NIDCR:1236408\","Non-SBIR/STTR RPGs","2018","NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH","","PHILADELPHIA","UNITED STATES","","02","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Project Narrative Our research is driven by the need to establish evidence-based tailored protocols for the oral care of head and neck cancer patients. The design presented is a disciplined clinical trial of an oral care intervention with the aim to carefully characterize the relationship between the clinical trajectory of oral mucositis (OM), the local levels of inflammatory changes, and the ebb and flow of the oral microbiota in head and neck cancer patients during radiation therapy. This research may result in a paradigm shift in clinical practice regarding the oral health needs of cancer patients, providing the basis for the development of better oral health interventions aimed at identifying therapy targets for reducing the risk and severity of OM and improving quality of life during cancer treatment.","9889601 (contact); 14922901; ","CORBY, PATRICIA M (contact); HU, KENNETH ;","FISCHER, DENA","09/15/2018","08/31/2023","","ARMOR Trial","027637","ZDE1","Special Emphasis Panel ","","","02","832489","403919","1236408",""
"9914688","UG1","DA","3","N","04/24/2019","02/15/2019","05/31/2019","279","UG1DA013035","SCHOOLS OF MEDICINE","RFA-DA-15-008","3UG1DA013035-17SA","NIDA:212814\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","NEW YORK","UNITED STATES","PSYCHIATRY","12","121911077","US","5998304","NEW YORK UNIVERSITY SCHOOL OF MEDICINE","NY","10016","PUBLIC HEALTH RELEVANCE:  Addictions, including nicotine, drugs and alcohol, represent a major public health problem. Research is needed to translate new basic and therapeutic advances into effective and accessible treatment in our communities. The NIDA Clinical Trials Network and the Greater New York Node seek to fill this gap by engaging researchers, healthcare providers from primary care to specialty care, and policy-makers in research to improve addictions treatment nationally using science as the vehicle.","8192463; 2414926 (contact); ","NUNES, EDWARD V.; ROTROSEN, JOHN P (contact);","DOBBINS, RONALD","01/10/2001","05/31/2020","Academia; addiction; Address; Adolescent; Adopted; Adoption; Alcoholism; Alcohols; Area; base; Behavior Therapy; behavioral health; Budgets; care coordination; care outcomes; care providers; Caribbean region; Caring; Charge; Cities; Clinical; Clinical Management; Clinical Trials; Clinical Trials Network; Collaborations; college; Communities; comparative effectiveness; cost; Criminal Justice; Data; Development; Disease; disorder prevention; Early Intervention; eHealth; Electronic Health Record; epidemiology study; experience; Fostering; Freedom; Funding; Future; Gender Issues; Genetic; Genetic Research; Goals; Health; health care service organization; health care settings; health information technology; health management; Health Personnel; Health Services; Health Services Research; Health system; Healthcare Systems; Hepatitis C virus; HIV; HIV/HCV; Hospitals; improved; improved outcome; Individual; Infection; Infrastructure; innovation; Institution; Leadership; Learning; Long Island; Mainstreaming; Medical; Medical Informatics; medical schools; medical specialties; Medical Technology; Medicine; Mental disorders; Mental Health; Mentorship; Methodology; Methods; metropolitan; mHealth; National Institute of Drug Abuse; neuroimaging; Neurosciences; Neurosciences Research; New York; next generation; Nicotine; Patients; Pediatrics; performance site; Pharmaceutical Preparations; Pharmacotherapy; Phase; Policy Maker; Population; pragmatic trial; Prevention; Primary Health Care; Private Hospitals; programs; Provider; Public Health; public health relevance; Public Hospitals; Registries; Research; Research Personnel; Research Training; Resources; Risk Reduction; Science; screening; Services; Smoking; Substance abuse problem; Substance Use Disorder; System; Technology Transfer; Testing; Therapeutic; Training; Translating; treatment program; treatment services; treatment strategy; Universities; vaccine development; Vision; ","NIDA Clinical Trials Network: Greater New York Node","013035","ZDA1","Special Emphasis Panel ","","SA","17","181437","31377","212814",""
"9572664","P30","EY","2","N","04/25/2019","04/01/2019","03/31/2020","","P30EY008098","","PAR-17-322","2P30EY008098-31","NEI:161381\","RESEARCH CENTERS","2019","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","","1863527; ","HENDRICKS, ROBERT L;","","","","base; Biological Assay; Cell Separation; Cells; Cellular Morphology; Computer software; Consult; Core Grant; Data Analyses; design; Development; experience; Faculty; Flow Cytometry; Fluorescent Antibody Technique; Fluorescent Dyes; Goals; Instruction; Label; Laboratory Personnel; Lasers; Learning; Measurement; Methodology; operation; Phenotype; Population; Principal Investigator; programs; Research; Research Personnel; Research Project Grants; Sampling; Scientist; Services; Signal Transduction; single cell analysis; Sorting - Cell Movement; Specific qualifier value; Speed; Suspensions; Techniques; Technology; theories; Training; Vision; Vision research; ","Flow Cytometry Core","008098","ZEY1","Special Emphasis Panel ","5952","","31","103119","58262","","161381"
"9627748","U10","CA","2","N","04/23/2019","04/19/2019","02/29/2020","","U10CA180899","","RFA-CA-17-057","2U10CA180899-06","NCI:2949534\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","OAKLAND","UNITED STATES","","13","128663390","US","1618201","PUBLIC HEALTH INSTITUTE","CA","946074046","","1857551; ","ALONZO, TODD A;","","","","Adolescent; anticancer research; Australia; base; Biology; Canada; Cancer Center; Cancer Patient; Caring; Child Support; Childhood; Childhood Cancer Treatment; Clinical; Clinical Research; Clinical Trials Design; Collaborations; Communities; Companions; Country; Data; data management; density; design; Development; Diagnosis; Disease; Ensure; Foundations; functional outcomes; Generations; Genomics; Goals; improved; improved outcome; innovation; Interdisciplinary Study; Investigation; Knowledge; Laboratories; Leadership; Malignant Childhood Neoplasm; Malignant Neoplasms; member; Methods; Molecular; Monitor; Morbidity - disease rate; mortality; multidisciplinary; New Zealand; novel; organizational structure; Outcome; Patients; Pediatric Hospitals; Pediatric Oncology Group; Population Research; programs; Quality of life; Reporting; Research; research study; Science; Statistical Data Interpretation; statistics; Survivors; survivorship; translational clinical trial; Translational Research; translational scientist; translational study; trial design; United States; Universities; ","COG SDMC - Statistics Core","180899","ZCA1","Special Emphasis Panel ","8347","","06","2958157","244365","","2949534"
"9638290","U10","CA","2","N","04/26/2019","04/26/2019","02/29/2020","395","U10CA180888","SCHOOLS OF MEDICINE","RFA-CA-17-056","2U10CA180888-06","NCI:8780513\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","INTERNAL MEDICINE/MEDICINE","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","PROJECT NARRATIVE SWOG?s clinical and translational research will lead to a better understanding of the biology underlying neoplastic disease and will ultimately enable those potentially affected by cancer to lead longer, healthier lives.","6765159; ","BLANKE, CHARLES D.;","MOONEY, MARGARET M","04/17/2014","02/28/2025","Accountability; Advocate; Affect; Applications Grants; Behavior; Biology; Canada; cancer clinical trial; cancer therapy; career; Clinical; Clinical Research; Clinical Trials; Communities; cost effective; design; Development; Disease; Enrollment; Ensure; Ethics; experience; Fostering; Foundations; Funding; Future Generations; Goals; Grant; Human; Immune; improved; innovation; Knowledge; Lead; Leadership; Malignant Neoplasms; member; Mentors; Mexico; Mission; Modality; National Clinical Trials Network; NCI-Designated Cancer Center; Neoplasms; neoplastic; next generation; oncology; operation; Pathway interactions; Patients; Persons; Physicians; Problem Solving; programs; Publishing; Regimen; Research; Research Personnel; Saudi Arabia; Science; Site; South America; South Korea; Southwest Oncology Group; standard of care; Therapeutic Trials; Time; tool; Training and Education; Translational Research; translational scientist; Translational trial; United States; United States Food and Drug Administration; Work; ","SWOG Network Group Operations Center of the NCTN","180888","ZCA1","Special Emphasis Panel ","","","06","10953895","1186086","8780513",""
"9663975","R01","HD","5","N","04/24/2019","04/01/2019","03/31/2020","865","R01HD067270","","PA-13-302","5R01HD067270-10","NICHD:925810\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","LEBANON","UNITED STATES","","02","150883460","US","10051750","DARTMOUTH-HITCHCOCK CLINIC","NH","037561000","PUBLIC HEALTH RELEVANCE: This study evaluates the effect of parental subfertility-related diagnoses on the health of women and their children and the associated healthcare costs. The original project developed a cohort through linkage of assisted reproductive technology data from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System and vital records data in Massachusetts. In this renewal we have enhanced the study with the following innovations: addition of comprehensive, detailed diagnostic and treatment outpatient data from the newly available Massachusetts All Payers Claims Database (APCD): increasing the cohort to approximately one million women and their children; addition of the contribution of the male parent to child health; and development of a detailed cost estimate.","9839425; 1934969 (contact); ","DIOP, HAFSATOU ; STERN, JUDY E (contact);","KING, ROSALIND B","06/17/2011","03/31/2021","1 year old; 4 year old; Acute; Admission activity; Affect; Age; Ambulatory Care; Anxiety; Applications Grants; Area; Assisted Reproductive Technology; Asthma; base; Birth; Birth Certificates; Blood Transfusion; Child; child bearing; Child Health; Childhood; Chronic lung disease; Clinic; cohort; Companions; comparison group; Conceptions; Congenital Abnormality; Control Groups; cost; Data; data registry; Data Sources; Databases; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Disease; early childhood; Early Intervention; Emergency department visit; endometriosis; Event; Family; Fathers; feeding; Fertility; Fetal Death; Foundations; Gestational Diabetes; Grant; Health; Health Care Costs; health of the mother; Heart Diseases; high risk; Hospital Costs; Hospitals; Hypertension; Immune System Diseases; infancy; Infant Health; Infertility; infertility treatment; Inflammatory; Information Systems; innovation; Insurance; Insurance Coverage; intervention program; Life; Link; longitudinal database; Low Birth Weight Infant; male; Massachusetts; Maternal Age; Measures; Medical; men; Mental Depression; Modality; Morbidity - disease rate; Mothers; Neonatal; neonatal period; neoplasm registry; Outcome; Outcome Measure; outpatient programs; Outpatients; ovarian reserve; Parents; Pediatric Intensive Care Units; perinatal health; Pharmaceutical Preparations; Population; population based; Postpartum Period; Pre-Eclampsia; Pregnancy; pregnancy hypertension; Pregnancy Outcome; Premature Birth; Procedures; public health relevance; Recording of previous events; Records; Reporting; repository; reproductive; Sample Size; Series; Small for Gestational Age Infant; Societies; Specialist; study population; Study Subject; subfertility; Surgical complication; System; Time; Tube; United States; Visit; Woman; Women's Group; Women's Health; ","Subfertility and Assisted Conception Study of Parent and Child Health Outcomes","067270","IRAP","Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section ","","","10","815087","110723","925810",""
"9665272","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:101362\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","Project Narrative  While it is widely recognized that a host of common diseases and disease outcomes differ  among populations defined by continental ancestry, it is usually unclear what the relative  contributions of different patterns of environmental exposures, different access to and utilization  of health care resources, and the different frequencies of alleles affecting risk of disease or  outcomes are to the observed differences in risk of disease and outcomes. We focus in this  project largely on building tools to identify and characterize, with respect to function and  biological mechanism, the genetic risk factors contributing to health disparities in disease and  outcomes, and then in the application of these tools to disease and outcome phenotypes  relevant to our project and to the larger health disparities research community.  The goals of this project are to 1) build resources that make it easier to identify the genetic  component to observed health disparities in disease risk and/or outcomes and 2)  investigate some specific health disparities in which genetic risk factors clearly  contribute to differences between continental population in lifetime risk of the phenotype of  interest.","3075104; ","COX, NANCY J;","","","","Academic Medical Centers; Affect; African; African American; American; Asthma; Back; base; biobank; Biological; Child; Clinical; Clinical Data; clinical data warehouse; Communities; Data; Databases; Demographic Factors; design; Disease; Disease Outcome; disease phenotype; disorder risk; DNA; Electronic Health Record; Environment; Environmental Exposure; European; Funding; Future; Gene Frequency; Genetic; genetic risk factor; Genome; genome sequencing; genome wide association study; Genotype; Geography; Goals; Grant; health care service utilization; health disparity; Hispanics; Individual; Infrastructure; interest; Investigation; Investments; lesbian, gay, bisexual; Lifetime Risk; Link; Malignant neoplasm of cervix uteri; Medicine; Methodology; Mexican Americans; novel; Outcome; Patients; Pattern; Phenotype; Population; population health; precision medicine; Premature Birth; Records; Research; Research Infrastructure; Resources; Risk; Sampling; social; Software Tools; tool; transgender; Universities; Variant; whole genome; ","Project 2- Using a Biobank and Electronic Health Records to Characterize Genome Variation Affecting Health Disparities","010722","ZMD1","Special Emphasis Panel ","8205","","04","95279","21199","","101362"
"9665787","R01","MH","5","N","04/23/2019","04/01/2019","03/31/2020","242","R01MH108427","","PA-14-132","5R01MH108427-04","NIMH:423210\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","PUBLIC HEALTH RELEVANCE: Antiretroviral therapy has the potential to greatly increase life expectancy and prevent transmission of HIV; however many HIV-infected individuals do not stay engaged in HIV care, which results in poor health outcomes. We propose to study long-term patterns of HIV care engagement and mortality, and the social, behavioral, and geographic factors that influence them. This work will inform physicians, policymakers, and governments on how to design interventions to maximize the long-term effectiveness of HIV treatment programs.","8036163; ","BASSETT, INGRID VALERIE;","SENN, THERESA ELAINE","04/07/2016","03/31/2020","Academia; Achievement; Africa South of the Sahara; antiretroviral therapy; base; Behavioral; Behavioral Model; Behavioral Sciences; Biometry; Caring; CD4 Lymphocyte Count; Censuses; Cessation of life; Clinical; clinical epidemiology; clinical research site; cohort; Cohort Studies; Communities; Consent; Continuity of Patient Care; Data; Data Sources; design; Diagnosis; Disease; effective intervention; Effectiveness; Emotional; Funding; Future; Geographic Factor; Geographic Information Systems; Geographic Locations; Geography; Government; Health; Health Benefit; health service use; Healthcare Systems; high risk; HIV; HIV diagnosis; HIV therapy; Hot Spot; Human immunodeficiency virus test; improved; Individual; innovation; Interruption; Intervention; Laboratories; Life Expectancy; Long-Term Care; Longitudinal Studies; Measures; Monitor; Morbidity - disease rate; mortality; Movement; multidisciplinary; National Institute of Mental Health; Nature; Newly Diagnosed; novel; novel strategies; One-Step dentin bonding system; Outcome; Participant; Patients; Pattern; Patterns of Care; Performance; Physicians; Play; Positioning Attribute; prevent; programs; Public Health; public health relevance; Registries; Reporting; Research; Research Personnel; Resources; Risk Factors; Services; social; Social Behavior; Social support; South Africa; South African; Statistical Data Interpretation; Statistical Models; Study Subject; success; Testing; therapy adherence; therapy design; Time; tool; transmission process; treatment program; treatment site; uptake; Viral Load result; virology; Work; ","What happens after diagnosis: Characterizing long-term HIV care trajectories and mortality in South Africa","108427","ZRG1","Special Emphasis Panel ","","","04","269082","154128","423210",""
"9668157","R01","GM","5","N","04/23/2019","04/01/2019","03/31/2020","859","R01GM112666","SCHOOLS OF ARTS AND SCIENCES","PA-13-302","5R01GM112666-04","NIGMS:311152\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","HADLEY","UNITED STATES","CHEMISTRY","02","153926712","US","850904","UNIVERSITY OF MASSACHUSETTS AMHERST","MA","010359450","PUBLIC HEALTH RELEVANCE: Heparin-related glycosaminoglycans (GAGs) hold enormous promise in the field of regenerative medicine, and their intimate involvement in cell proliferation and differentiation, as well as in immune regulation also makes them a largely unexploited source of therapeutic agents that can address a variety of other medically important conditions. Nevertheless, their clinical applications are still confined to anticoagulants, while progress in other areas remains relatively modest. The proposed research will make a critical contribution towards understanding the interaction between heparin-related GAGs and several therapeutically relevant proteins, which will catalyze efforts to develop novel safe and potent drug delivery systems for wound healing and treatment of pathological conditions, ranging from cancer to Parkinson's and Alzheimer's diseases.","6379082; ","KALTASHOV, IGOR A;","KREPKIY, DMITRIY","04/01/2016","03/31/2020","Address; Adopted; Affinity; Alzheimer's Disease; angiogenesis; Anticoagulants; Antithrombin III; Area; base; Binding; Binding Sites; Biopolymers; Blood coagulation; cationic antimicrobial protein CAP 37; Cell Adhesion; Cell Differentiation process; Cell Proliferation; Charge; Chemistry; Clinic; Clinical; clinical application; Complex; Crystallization; Data; design; Detection; Deuterium; Digestion; Disease; Dissociation; Drug Delivery Systems; Electrons; Electrostatics; Embryonic Development; Exhibits; Family; Fibroblast Growth Factor; Gases; Glycosaminoglycans; Goals; Heparin; Heparin Lyase; Heparinoids; Heterogeneity; holistic approach; Hydrogen; immunogenic; immunoregulation; improved; Inflammation; ion mobility; Ion-Exchange Chromatography Procedure; Ions; Kinetics; Knowledge; Length; Malignant Neoplasms; Mass Spectrum Analysis; Measures; Medical; Medicine; member; Methodology; Modality; Modeling; Molecular; Molecular Conformation; molecular modeling; Monte Carlo Method; Multiple Partners; Neoplasm Metastasis; Neurodegenerative Disorders; novel; oncology; Parkinson Disease; Pathologic; Pharmacology; Phase; Physiological; Physiological Processes; Polymers; Polysaccharides; Process; Property; protein complex; Proteins; public health relevance; Regenerative Medicine; Research; Resolution; Role; scaffold; simulation; Source; Spectrometry, Mass, Electrospray Ionization; stoichiometry; structural biology; Structure; Techniques; Therapeutic; Therapeutic Agents; Therapeutic Effect; therapeutic target; Tissue Engineering; tissue regeneration; tool; Vertebral column; Work; Wound Healing; ","An integrated mass spectrometry approach to study heparin structure-bioactivity","112666","EBIT","Enabling Bioanalytical and Imaging Technologies Study Section ","","","04","200000","111152","311152",""
"9669070","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","859","P20GM121316","SCHOOLS OF MEDICINE","PAR-16-415","5P20GM121316-02","NIGMS:2270230\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","Project Narrative: Overall Center Organization and Management Plan The goal of the Nebraska Center for Molecular Target Discovery and Development is to establish and expand physical and intellectual resources at the University of Nebraska Medical Center (UNMC) and the University of Nebraska system that will catalyze the ability of its faculty to define, validate, and develop potential therapies against molecular targets for clinically important diseases.","1903126; ","LEWIS, ROBERT E.;","ALEXANDER, RASHADA","03/16/2018","02/28/2023","Appointment; Area; Award; Awareness; Basic Science; Belief; bench to bedside; Bioinformatics; Biology; Biomedical Research; career; Career Mobility; Centers of Research Excellence; Chemicals; Clinical; Collaborations; college; Communities; computational chemistry; cost; Development; Discipline; Disease; Epigenetic Process; experience; Extramural Activities; Faculty; Financial Support; Future; genetic analysis; genome sequencing; Genomics; Goals; Grant; Health; high throughput screening; Human; Image; improved; In Vitro; in vivo; Infrastructure; insight; Institution; interest; Investments; Knowledge; man; Mass Spectrum Analysis; Medical center; member; Mentors; Modernization; Molecular; Molecular Analysis; Molecular Target; Nebraska; new therapeutic target; novel lead compound; novel therapeutics; operation; Pre-Clinical Model; preclinical development; programs; Reagent; Research; Research Personnel; Research Support; Resource Development; Resource Sharing; Resources; RNA Interference; RNA interference screen; screening; skills; small molecule; System; targeted treatment; Teacher Professional Development; Therapeutic; therapeutic development; therapeutic target; Training; translational research program; undergraduate research; undergraduate student; Universities; Validation; Vision; ","Nebraska Center for Molecular Target Discovery and Development","121316","ZGM1","Special Emphasis Panel ","","","02","1506972","763258","2270230",""
"9669089","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:279075\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","11933197; ","CONDA SHERIDAN, MARTIN MIGUEL;","","","","Affinity; Antineoplastic Agents; Apoptosis; Atomic Force Microscopy; base; Binding; Biological; Blood Circulation; cancer cell; Cancer Model; Cause of Death; Cell Line; Cell Survival; Cells; Cellular Assay; Characteristics; Charge; claudin-1 protein; Colon; Colon Carcinoma; Colonic Neoplasms; computational chemistry; Computer Simulation; computerized tools; design; Development; Dissociation; Dose; Drug Delivery Systems; Drug toxicity; effective therapy; Encapsulated; Epitopes; Erythrocytes; experimental study; Fiber; Fluorescence; Fluorouracil; Goals; Hemolysis; improved; In Vitro; in vivo; Integral Membrane Protein; Lesion; Libraries; Ligands; light scattering; Malignant Neoplasms; Mass Spectrum Analysis; men; metastatic colorectal; Metastatic to; Micelles; Molecular Target; Morphology; Mus; nanocarrier; nanofiber; Nanosphere; Nanostructures; nanosystems; Nebraska; Neoplasm Metastasis; neoplastic cell; Normal Cell; Normal tissue morphology; novel; novel therapeutics; Organ; overexpression; Peptides; Performance; Pharmaceutical Preparations; Physiological; Plasma; Property; Proteins; Publishing; receptor binding; receptor internalization; Reporting; Research; Role; Shapes; Specificity; Structure; Surface Plasmon Resonance; Surveys; System; targeted treatment; Techniques; Testing; Therapeutic Agents; Time; Toxic effect; Transmission Electron Microscopy; Validation; Water; Woman; zeta potential; ","Developing Targeted Therapeutic Nanosystems to Treat Metastatic Colon Cancer","121316","ZGM1","Special Emphasis Panel ","8791","","02","183000","96075","","279075"
"9669896","R01","AR","5","N","04/26/2019","03/01/2019","02/29/2020","846","R01AR071614","SCHOOLS OF MEDICINE","PA-16-160","5R01AR071614-02","NIAMS:339900\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","BALTIMORE","UNITED STATES","ORTHOPEDICS","07","188435911","US","820104","UNIVERSITY OF MARYLAND BALTIMORE","MD","212011508","PROJECT NARRATIVE There is a consensus that bone embedded osteocytes sense mechanical load, leading to the regulation of sclerostin, a key modulator of bone remodeling. However, fundamental aspects of how these cells sense and respond to mechanical load and how calcium influx leads to changes in sclerostin bioavailability are unknown. In this grant, we explore the role of the microtubules in modulating mechano-responsiveness by tuning cytoskeletal stiffness, impacting calcium channel activation, signal transduction and the transcriptional and translational control of sclerostin ultimately affecting bone quality.","6933724 (contact); 2110331; ","STAINS, JOSEPH P. (contact); WARD, CHRISTOPHER WILLIAM;","NICKS, KRISTY","03/21/2018","02/28/2023","Acute; Affect; Aging; alpha Tubulin; base; beta catenin; Biological; Biological Availability; Biomechanics; bone; bone loss; bone mass; bone quality; Bone remodeling; Calcium; Calcium Channel; Calmodulin; Cations; Cell physiology; Cells; Cilia; Consensus; crosslink; Cues; Cultured Cells; Cytoskeleton; Data; defined contribution; density; Disease; Down-Regulation; Drug Targeting; economic impact; Elements; Enzymes; Genes; Genetic; genetic approach; Genetic Transcription; Grant; Health; Human; improved; In Vitro; in vivo; in vivo Model; insight; Integrins; Knockout Mice; Knowledge; Link; Liquid substance; loss of function; mechanical load; Mechanical Stress; Mechanics; mechanotransduction; Mediator of activation protein; Messenger RNA; Microtubule-Associated Proteins; Microtubules; Modeling; Molecular; mutant; Mutation; NADPH Oxidase; new therapeutic target; novel; Osteocytes; Osteogenesis; osteogenic; Osteoporosis; Outcome; Outcome Measure; Pathway interactions; Patients; Pharmacology; Phenotype; Phosphotransferases; Play; Post-Translational Protein Processing; prevent; primary outcome; Proteins; Reactive Nitrogen Species; Reactive Oxygen Species; receptor; Regulation; Repression; response; Role; Second Messenger Systems; sensor; shear stress; Signal Pathway; Signal Transduction; skeletal; skeletal disorder; Skeleton; Source; Striated Muscles; Structure; Testing; Tissues; tool; Translating; Tubulin; Vanilloid; Work; ","Mechanisms of osteocyte mechano-signaling and sclerostin regulation","071614","SBDD","Skeletal Biology Development and Disease Study Section ","","","02","220000","119900","339900",""
"9672449","P30","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P30ES009089","","RFA-ES-17-003","5P30ES009089-21","NIEHS:240000\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","NEW YORK","UNITED STATES","","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","","7839598; ","PERZANOWSKI, MATTHEW S;","","","","Advisory Committees; Applications Grants; Area; Award; career; Climate; Communities; Core Facility; Data; Development; Disease; disorder prevention; Doctor of Philosophy; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Epigenetic Process; Extramural Activities; Faculty; faculty support; Fostering; Funding; Future; Goals; Grant; Health; health science research; innovation; interest; investigator training; K-Series Research Career Programs; Life Cycle Stages; Measures; member; novel; Pilot Projects; Process; programs; Publications; Recording of previous events; recruit; Research; research and development; Research Personnel; Research Project Grants; Research Training; response; Scientist; senior faculty; success; Translations; Universities; Washington; working group; ","Pilot Project Program","009089","EHS","Environmental Health Sciences Review Committee ","7567","","21","150000","90000","","240000"
"9672564","P01","HL","5","N","04/26/2019","04/01/2019","03/31/2020","837","P01HL136267","SCHOOLS OF MEDICINE","PAR-13-316","5P01HL136267-03","NHLBI:2259697\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BIRMINGHAM","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","OVERALL ? PROJECT NARRATIVE This PPG focuses on elucidating mechanisms by which the kidney controls sodium excretion, and therefore, has direct relevance to the serious health problem of salt-dependent hypertension and kidney disease. The three main projects each utilize relevant animal models and sophisticated in vitro techniques to uncover the pathways that lead to salt-dependent high blood pressure as well as uncovering ways to combat significant side effects of the relevant class of drugs known as endothelin receptor antagonists. We expect these studies will be important in guiding future clinical and therapeutic practices for a broad range of cardiovascular and related diseases.","1869893; ","POLLOCK, DAVID M;","OH, YOUNGSUK","05/01/2017","03/31/2022","Accounting; Acetylation; Adult; Adverse effects; American; Angiotensins; Animal Model; Animals; ARNTL gene; Attention; Awareness; Biology; Blood Circulation; Blood Pressure; blood pressure regulation; Blood Vessels; Body Fluids; Breeding; Businesses; Cardiovascular Diseases; cardiovascular risk factor; Cardiovascular system; Cell physiology; Cilia; circadian; circadian pacemaker; circadian regulation; Clinical; clinical development; Collecting Cell; combat; Complement; data management; Deacetylation; Defect; dietary salt; Disease; Duct (organ) structure; Ductal Epithelial Cell; Electrolyte Balance; Electrolytes; Elements; Endothelin; Endothelin Receptor Antagonist; Endothelin-1; Ensure; Enzymes; Equilibrium; Estrogens; Excretory function; fluid flow; Future; gene function; Genes; Genotype; Goals; Gonadal Steroid Hormones; HDAC1 gene; Health; hemodynamics; high salt diet; Histone Deacetylase; Homeostasis; Human; Hypertension; Immune System Diseases; In Vitro; Inflammatory; innovation; Kidney; Kidney Diseases; Knowledge; Laboratories; Lead; Liquid substance; Mediating; Mediator of activation protein; meetings; Molecular; Monitor; Nitric Oxide; NOS1 gene; NOS3 gene; novel; Pathway interactions; Patients; Peptides; Pharmaceutical Preparations; Physiological; Population; Process; Production; Program Development; Program Research Project Grants; programs; receptor; Receptor Activation; Regulation; Regulatory Pathway; Renin; Research Personnel; Risk; Risk Factors; Rodent; Role; salt intake; saluretic; Schedule; Scheme; Sex Characteristics; Signal Transduction; Sodium; Sodium Chloride; Statistical Data Interpretation; success; synergism; System; Techniques; Testing; Testosterone; Therapeutic; Time; Tubular formation; Variant; Vasoconstrictor Agents; Water; ","Integrating novel mechanisms controlling sodium excretion and blood pressure","136267","HLBP","Heart, Lung, and Blood Initial Review Group ","","","03","1756435","503262","2259697",""
"9676320","P30","ES","5","N","04/26/2019","04/01/2019","03/31/2020","","P30ES027792","","RFA-ES-16-001","5P30ES027792-03","NIEHS:128576\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","CHICAGO","UNITED STATES","","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","","9420304; ","KIM, KAREN E;","","","","Address; Advisory Committees; African American; Air Pollution; Area; Asian Americans; Caucasians; Chicago; Cities; Collaborations; Communication; Communities; community based participatory research; Community Health; Community Health Aides; Community Outreach; Country; Decision Making; Diabetes Mellitus; Disease; Effectiveness; Environment; Environmental Exposure; Environmental Hazards; Environmental Health; Environmental Pollution; ethnic diversity; experience; Exposure to; Fostering; Future; Goals; hazard; Health; health disparity; Health Personnel; Health Policy; Health Promotion; Hispanic Americans; Hispanics; Hypertension; Illinois; implementation strategy; improved; Infrastructure; Institution; Joints; Journals; Lead; Maintenance; Minority; Mission; Neighborhoods; outreach; Policies; Politics; Population; Population Heterogeneity; Positioning Attribute; Problem Solving; Process; programs; Public Health; Quality of life; Recording of previous events; Research; research and development; Research Design; Research Personnel; Resources; Series; Side; Supervision; therapy design; Training; Translational Research; Translations; Underserved Population; Universities; Vision; Water Pollution; Work; ","Community Engagement Core","027792","ZES1","Special Emphasis Panel ","7105","","03","114102","14474","","128576"
"9676321","P30","ES","5","N","04/26/2019","04/01/2019","03/31/2020","","P30ES027792","","RFA-ES-16-001","5P30ES027792-03","NIEHS:228497\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","CHICAGO","UNITED STATES","","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","","8550188; ","MUTLU, GOKHAN M.;","","","","Address; Applications Grants; Area; Award; Biological Markers; career; career development; Centers for Disease Control and Prevention (U.S.); Chicago; Collaborations; Communities; community based participatory research; Core Facility; Data; Development; Discipline; Environment; Environmental Health; environmental justice; Environmental Risk Factor; ethnic health disparity; Faculty; Fostering; Funding; Funding Agency; Future; Grant; Growth; Health; health disparity; health science research; Health Sciences; Illinois; innovation; Institutes; inter-institutional; Lead; Leadership; member; Mentors; Methods; Modeling; National Institute of Environmental Health Sciences; next generation; Participant; Pilot Projects; Plant Roots; programs; Progress Reports; Publications; racial and ethnic; Research; Research Personnel; Research Project Grants; Research Support; Resources; statistics; success; Testing; United States National Institutes of Health; Universities; Work; ","Pilot Program Core","027792","ZES1","Special Emphasis Panel ","7106","","03","193181","35316","","228497"
"9677117","R01","CA","5","N","04/24/2019","04/01/2019","03/31/2020","393","R01CA129933","","PA-16-160","5R01CA129933-12","NCI:362936\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Project Narrative Primary and metastatic cancers shed cells into the bloodstream. These circulating tumor cells (CTCs) underlie the blood-borne spread of cancer, and they also provide a noninvasive source of cancer cells for monitoring response, progression and acquired drug resistance during the course of therapy. We have established primary cultures of CTCs from women with advanced drug-resistant estrogen receptor (ER)- positive breast cancer, and have shown that these comprise heterogeneous cell populations, capable of switching between proliferative (HER2+) and drug resistant (Notch1+) phenotypes. Moreover, cultured human CTCs exhibit striking differences in tumor initiation in mouse models: highly tumorigenic following orthotopic organ inoculation but primarily quiescent after direct intravascular inoculation. We propose to determine key regulators of CTC-derived tumorigenesis, using a combination of RNA and proteomic profiling, pooled bar-coded knockdown libraries, and reconstituted mouse models, followed by validation of candidate genes and pathways in primary human CTCs.","1882057; ","HABER, DANIEL A.;","FINGERMAN, IAN M","04/01/2008","03/31/2023","acquired drug resistance; advanced breast cancer; Affect; Bar Codes; Biological; Biological Assay; Blood; Blood Circulation; Blood specimen; bone; Brain; Breast; Breast Cancer Cell; Breast cancer metastasis; breast cancer progression; cancer cell; Candidate Disease Gene; candidate validation; Cell Culture Techniques; Cell Line; Cells; Chromatin; Clinical; Deposition; Disease; Disease Resistance; Disseminated Malignant Neoplasm; Distant; Drug or chemical Tissue Distribution; Drug resistance; drug sensitivity; Engineering; Epigenetic Process; ERBB2 gene; Estrogen receptor positive; Estrogen Receptors; Evolution; Exhibits; experience; experimental study; Funding; Gene Expression; Genes; Genetic Transcription; Goals; Hematopoietic; Human; Hypoxia; implantation; In Vitro; in vitro testing; in vivo; Individual; Injections; Intravenous; Jordan; knock-down; Libraries; Link; Liver; Lung; malignant breast neoplasm; Malignant Neoplasms; Mammary gland; Mass Spectrum Analysis; Mediating; Mediator of activation protein; Metastatic breast cancer; Metastatic malignant neoplasm to brain; Metastatic to; methylation pattern; Microfluidics; Modeling; Molecular; Molecular Analysis; Monitor; mouse model; Nature; Neoplasm Circulating Cells; Neoplasm Metastasis; neoplastic cell; notch protein; Organ; Pathway interactions; Patients; Phenotype; Population; Primary Neoplasm; Process; Property; Proteome; Proteomics; Reactive Oxygen Species; real time monitoring; reconstitution; Reporter; Resistance; Resistance development; response; RNA; Sampling; Science; single-cell RNA sequencing; Site; small hairpin RNA; Source; Specimen; Stains; Stress; SWI1; Tail; Technology; Testing; Therapeutic Intervention; Time; Tissues; transcriptome; transcriptome sequencing; Tropism; tumor; Tumor Cell Line; tumor growth; tumor initiation; Tumor Initiators; Tumor-Derived; tumorigenesis; tumorigenic; Validation; Veins; Woman; ","Modeling Metastasis and Acquired Drug Resistance Using Circulating Tumor Cells","129933","ZRG1","Special Emphasis Panel ","","","12","221887","141049","362936",""
"9683872","R01","DA","5","N","04/24/2019","04/01/2019","03/31/2020","279","R01DA016903","SCHOOLS OF ARTS AND SCIENCES","PA-11-311","5R01DA016903-15","NIDA:644173\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","DURHAM","UNITED STATES","MISCELLANEOUS","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","PUBLIC HEALTH RELEVANCE: This project will follow participants in two prospective studies (Child Development Project and Fast Track) through age 34 in order to identify early childhood risk profiles for antisocial behavior, substance abuse, and risky sexual behavior with high enough detail to guide prevention programmers. Analyses will evaluate the impact of random assignment to the Fast Track Prevention Program on adult health, well-being, and financial burden.","11204885; 1862773 (contact); 1876324; ","CROWLEY, DANIEL MAX; DODGE, KENNETH A (contact); MCMAHON, ROBERT J.;","LLOYD, JACQUELINE","09/20/2003","03/31/2020","Accountability; Adolescent; Adult; Age; Alcohol or Other Drugs use; Alcohols; antisocial behavior; Behavior Therapy; Child; Child Development; Child Rearing; Childhood; cognitive skill; Collection; Communities; conduct problem; cost; criminal behavior; Criminal Justice; Data Collection; Development; drug misuse; early childhood; Early Intervention; Economics; effective intervention; Employment; Failure; Fast Track intervention; Financial cost; follow-up; Future; Gender; Goals; Government; Grain; Guide prevention; Health; high risk; high risk sexual behavior; improved; Individual; innovation; Intervention; Interview; Investments; kindergarten; Life; Longitudinal Studies; Maps; Measurement; Medicaid; Meta-Analysis; Modeling; Outcome; Participant; Personal Satisfaction; Pharmaceutical Preparations; Policies; Policy Maker; Population; Preschool Child; prevent; Prevention; Prevention program; Preventive Intervention; Problem behavior; programs; prospective; Prospective Studies; Psychopathology; psychosocial; Public Health; public health relevance; Public Policy; Race; Randomized Controlled Trials; Records; Research; Resources; retention rate; Risk; Risk Adjustment; Risk Factors; Sampling; Savings; Schools; Science; Scientist; Series; service programs; service utilization; Services; Site; social; Social Behavior; social skills; Specific qualifier value; Subgroup; Substance abuse problem; success; System; Tobacco; Translating; Uncertainty; Variant; violent crime; young adult; ","Optimizing Prevention of Costly Adult Outcomes","016903","ZRG1","Special Emphasis Panel ","","","15","429625","214548","644173",""
"9686378","P30","ES","2","N","04/26/2019","04/01/2019","03/31/2020","","P30ES000002","","RFA-ES-18-003","2P30ES000002-56","NIEHS:298161\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BOSTON","UNITED STATES","","07","149617367","US","3212904","HARVARD SCHOOL OF PUBLIC HEALTH","MA","021156028","","9338056; ","LU, QUAN ;","","","","Area; Biological; biomarker development; biomarker discovery; Cells; Core Facility; Development; Disease; disorder risk; Early Diagnosis; environmental chemistry; Environmental Exposure; Environmental Health; environmental intervention; Equipment; Future; Genomics; Goals; Health Sciences; Health Services; improved; instrumentation; Measurement; Medical; Methods; microbiome; Mission; Molecular; National Institute of Environmental Health Sciences; Population; Population Study; Postdoctoral Fellow; Preventive Intervention; Research; Research Personnel; Research Training; Resources; Sampling; Schools; Scientist; Services; student training; Technology; Training; Translational Research; ","Integrated Health Service Facility Core","000002","EHS","Environmental Health Sciences Review Committee ","5373","","56","186935","111226","","298161"
"9686380","P30","ES","2","N","04/26/2019","04/01/2019","03/31/2020","","P30ES000002","","RFA-ES-18-003","2P30ES000002-56","NIEHS:297983\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BOSTON","UNITED STATES","","07","149617367","US","3212904","HARVARD SCHOOL OF PUBLIC HEALTH","MA","021156028","","1895772; ","LADEN, FRANCINE ;","","","","Area; Behavioral; Behavioral Sciences; Biometry; Censuses; Characteristics; Collection; community center; Community Outreach; contextual factors; Core Facility; Data; data management; Data Sources; demographics; digital; Educational Activities; Educational workshop; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Epidemiology; Faculty; field study; Geographic Factor; Geographic Information Systems; Geography; graduate student; health data; Infrastructure; Interdisciplinary Study; interest; Joints; Longitudinal cohort; Measures; member; Metals; Methodology; National Institute of Environmental Health Sciences; Neighborhoods; particle; Phenotype; predictive modeling; Privacy; Publications; Research; Research Activity; Research Personnel; Resolution; Resources; Sampling; Schools; Science; Series; Services; smartphone Application; social; Social Sciences; stressor; Training; web site; Work; ","Geographic & Contextual Measures Core","000002","EHS","Environmental Health Sciences Review Committee ","5375","","56","186823","111160","","297983"
"9687699","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","143","P42ES004705","SCHOOLS OF PUBLIC HEALTH","RFA-ES-15-019","5P42ES004705-31","NIEHS:2159198\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","OVERALL: PROJECT NARRATIVE We have identified four complex problems associated with hazardous waste sites that have proven intractable to current methods in consultation with the Program's key stakeholders. We are applying a new approach aimed at `seeing the whole picture' called `exposomics' to address these problems and will employ novel cutting-edge scientific methods and direct engagement with key stakeholders and communities in a concerted effort to make a public health impact.","1883460; ","SMITH, MARTYN T;","HEACOCK, MICHELLE","04/01/1997","03/31/2022","Address; adduct; Adopted; Animal Model; Aromatic Hydrocarbons; Aromatic Polycyclic Hydrocarbons; Arsenic; Benzene; bilingualism; Bioinformatics; Biomedical Engineering; Biometry; Bioremediations; California; Cancer Patient; Cell model; Chemical Exposure; Chemicals; chemoproteomics; Chromium; Collaborations; Communities; community based participatory research; community living; Complex; Consultations; contaminated drinking water; Data; Data Science; design; Detection; Development; Diabetes Mellitus; Disease; Dose; drinking water; early life exposure; Endocrine system; Endocrine System Diseases; Engineering; Ensure; Environment; Environment and Public Health; environmental chemical; Environmental Engineering technology; Environmental Exposure; Environmental Health; environmental justice; Environmental Protection; environmental stressor; environmental toxicology; epidemiology study; Ethnic Origin; Evaluation; exposed human population; Exposure to; Face; Formaldehyde; Glucocorticoids; Goals; Gonadal Steroid Hormones; ground water; Growth; Hand; Hazard Identification; Hazardous Substances; Hazardous Waste Sites; Health; Health protection; Human; human subject; Hypertension; improved; Infrastructure; innovation; insight; Knowledge; Laboratories; Laws; lipid metabolism; Malignant neoplasm of prostate; Malignant Neoplasms; Maps; meetings; Mentorship; Methods; microbial community; multidisciplinary; new technology; next generation; non-genetic; novel; novel strategies; Obesity; Pathway interactions; Poisons; Policies; Population; Predisposition; Prevention; programs; Proteome; Psychosocial Stress; Public Health; Regulation; remediation; Research; Research Ethics; Research Personnel; Risk; Risk Assessment; Role; Site; social; Socioeconomic Status; Solvents; steroid metabolism; Stress; stressor; success; Superfund; superfund chemical; superfund site; Systems Biology; Techniques; Technology; tool; Toxic effect; Toxicology; Training; Training and Education; Translating; Translational Research; Translations; Trichloroethylene; Water; water quality; Work; ","Toxic Substances in the Environment","004705","ZES1","Special Emphasis Panel ","","","31","1482030","677168","2159198",""
"9687716","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:162660\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","CORE B: PROJECT NARRATIVE The Community Engagement Core - Water Equity Science Shop will facilitate bidirectional collaboration between community-based organizations and UC researchers in order to address community-identified environmental health research needs related to drinking water contamination in socially and economically disadvantaged communities, including private well users who fall outside the purview of existing drinking water monitoring and regulation. Knowledge gained through the Core's activities will inform effective intervention strategies to prevent and reduce exposures to arsenic, nitrate and other contaminants that exceed regulatory standards among communities reliant on domestic wells and small community water systems.","9659033; ","MORELLO-FROSCH, RACHEL ADELE;","","","","Address; Advocacy; Advocate; Affect; agricultural activity; Agriculture; Applied Research; Area; Arsenic; Back; base; bilingualism; Biomedical Engineering; California; Chemical Exposure; Chemicals; Chromium; Collaborations; Communication; Communities; community based participatory research; community center; community organizations; comparative; Comprehension; Consensus; contaminated drinking water; contaminated water; Data; Development; Disadvantaged; drinking water; Economically Deprived Population; Economics; effective intervention; Effectiveness; Effectiveness of Interventions; Engineering; Environment; Environmental Health; environmental justice; Ethics; European; experience; Exposure to; Face; falls; Feedback; field study; Funding; Future; Government Agencies; ground water; Hazardous Substances; Health; Household; improved; Incubated; Individual; Industrialization; Information Dissemination; Infrastructure; innovation; Intervention; Intervention Studies; Interview; Joints; Knowledge; Laboratories; Latino; Laws; Legal; Low income; member; Methods; Modeling; Monitor; Needs Assessment; Nitrates; Nongovernmental Organizations; Participant; Pesticides; Pilot Projects; Poisons; Policies; Policy Maker; prevent; Privatization; Process; programs; Protocols documentation; Regulation; Reporting; Research; Research Methodology; Research Personnel; Resources; Risk; Rural; Safety; Science; Science Policy; Services; Shapes; social; socioeconomic disadvantage; Source; Superfund; Surveys; System; Technology; Test Result; Testing; tool; Training; Translational Research; Universities; Water; water quality; water sampling; webinar; Work; ","Core B: Community Engagement Core","004705","ZES1","Special Emphasis Panel ","5065","","31","104850","57810","","162660"
"9687723","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:217829\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","PROJECT 3: NARRATIVE We propose to develop and apply different analytical platforms to map proteome-wide targets of reactive Superfund chemicals to identify novel toxicological mechanisms with a particular focus on understanding how cumulative exposures to reactive environmental chemicals impact fat and steroid metabolism. This will contribute to our knowledge of the impact of mixed chemical exposures and reveal some of the complex mechanisms by which chemicals cause toxicity.","9164782; ","NOMURA, DANIEL KOJI;","","","","Address; Amino Acids; Aromatic Polycyclic Hydrocarbons; Arsenic; base; Behavioral; Benzene; Biochemical; Biological Markers; Chemical Exposure; Chemicals; chemoproteomics; Complex; complex biological systems; Complex Mixtures; Data; Environment; environmental chemical; Exposure to; fat burning; Fatty acid glycerol esters; Fatty Acids; Functional disorder; hazard; Hazardous Chemicals; Health; Hepatic; High Fat Diet; Hormones; Human; Hydrocortisone; in vivo; Individual; innovation; innovative technologies; insight; Knowledge; Leukocytes; Link; lipid metabolism; Lipids; Maps; Measures; Metabolism; metabolomics; Methods; Molecular Target; Mus; novel; Pathologic; Pathway interactions; Physiology; Poisons; Population; Protein Inhibition; protein profiling; Proteins; Proteome; Proteomics; remediation; Risk; Serum; Signal Recognition Particle; Steroid biosynthesis; steroid hormone; steroid metabolism; Steroids; superfund chemical; superfund site; Technology; Testosterone; Tissues; Toxic effect; Toxicology; Trichloroethylene; tumor; Vulnerable Populations; Water; ","Project 3: Mapping Proteome-Wide Reactivity of Superfund Chemicals Using Chemoproteomic Platforms","004705","ZES1","Special Emphasis Panel ","5070","","31","148145","69684","","217829"
"9700661","P41","EB","5","N","04/26/2019","03/01/2019","02/29/2020","286","P41EB015922","SCHOOLS OF MEDICINE","PAR-17-083","5P41EB015922-22","NIBIB:1217435\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","Los Angeles","UNITED STATES","OPHTHALMOLOGY","34","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PROJECT NARRATIVE - OVERALL The comprehensive suite of technologies include algorithmic and computational methods for image management, processing, data analysis and visualization. The technologies are ideally suited to enable holistic studies of the interactions between different imaging data modalities, phenotypic population characteristics, and physiological brain connectivity.","6111760; 6855806 (contact); ","THOMPSON, PAUL M; TOGA, ARTHUR W (contact);","DUAN, QI","09/30/1998","02/28/2023","Address; AIDS/HIV problem; algorithmic methodologies; Alzheimer's Disease; Anatomy; Atlases; Autistic Disorder; Award; base; Behavioral; Books; Brain; Brain imaging; Brain Mapping; brain shape; Clinical Data; Clinical Research; cohort; Communities; computer grid; computer infrastructure; Computer software; computerized data processing; Computing Methodologies; Coupled; Data; Data Analyses; Data Analytics; data archive; data management; data resource; Data Science; Data Set; data visualization; Databases; deep learning; Dementia; design; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Environment; Equilibrium; Evolution; Fiber; Funding; high dimensionality; Image; imaging genetics; imaging modality; improved; Informatics; Infrastructure; innovation; Investigation; Laboratories; Manuscripts; Mathematics; Methodology; Methods; Modality; Modeling; morphometry; Nature; Nerve Degeneration; Neurobiology; neuroimaging; new technology; novel; Parkinson Disease; Peer Review; Phenotype; Physiological; Population; Population Characteristics; Process; programs; Protocols documentation; Publications; Publishing; Reproducibility; Research Activity; Research Personnel; Resources; Schizophrenia; Science; Services; Software Tools; Specificity; Statistical Data Interpretation; Structure; Students; Surface; symposium; synergism; System; Technology; technology research and development; Tissues; tool; tractography; Training; translational study; United States National Institutes of Health; Visualization software; web services; ","Laboratory of Neuro Imaging Resource (LONIR)","015922","ZEB1","Special Emphasis Panel ","","","22","749999","467436","1217435",""
"9701965","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:266956\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","","2084822; ","PATTI, MARY E;","","","","Antibodies; Base Sequence; Basic Science; Bioenergetics; Bioinformatics; Biological Assay; Blood; Blood specimen; Boston; Cells; Clinical Research; Collaborations; Collection; Communities; Complementary DNA; Complications of Diabetes Mellitus; cost; Cultured Cells; Data; Data Analyses; Defect; Detection; Diabetes Mellitus; diabetes risk; digital; Disease; DNA; DNA analysis; Equipment; Functional disorder; Gene Expression; Gene Mutation; Genes; Genetic; Genetic study; Genomics; Genotype; Genus Hippocampus; Human; Immunology; Individual; induced pluripotent stem cell; insight; instrument; Insulin-Dependent Diabetes Mellitus; Intervention Studies; Laboratories; Libraries; Maintenance; Metabolic; metabolic phenotype; Metabolism; metabolomics; Methodology; Methods; Mitochondria; Molecular; molecular phenotype; Mus; Mutation; Names; neonatal diabetes mellitus; next generation sequencing; Non-Insulin-Dependent Diabetes Mellitus; novel; Observational Study; Participant; Pathway interactions; Phenotype; Plasma; Preparation; Proteins; Proteomics; repository; Research; Research Design; Research Personnel; research study; RNA; Sampling; Sequence Analysis; Services; SNP genotyping; Standardization; Stream; Technology; Time; Tissue Sample; Tissues; Training; Translational Research; treatment response; Universities; Untranslated RNA; Work; ","Molecular Phenotyping and Genotyping Core","036836","ZDK1","Special Emphasis Panel ","7096","","33","158196","108760","","266956"
"9702548","P40","OD","2","N","04/22/2019","04/01/2019","03/31/2020","","P40OD010952","","PAR-17-006","2P40OD010952-24","OD:509308\","RESEARCH CENTERS","2019","OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH","","KEY BISCAYNE","UNITED STATES","","27","152764007","US","10011242","UNIVERSITY OF MIAMI ROSENTEIL SCHOOL","FL","331491031","The California sea hare, Aplysia californica, is a large marine snail that has proven to be an outstanding model for studies of how the nervous system functions, particularly in memory and learning, as well as in understanding human diseases that affect these functions. The National Resource for Aplysia raises and ships 10,000 to 15,000 of these animals per year to research laboratories. This proposal would continue the production of these animals and expand their usefulness for studies of aging, lifespan extension, and mechanisms of resistance to the type of nervous system injuries encountered in stroke.","1865602; ","SCHMALE, MICHAEL C;","","","","Adult; Affect; Age; aged; Aging; Animals; Aplysia; Aplysia species; Applied Research; base; Behavior; Biological Models; Biomedical Research; Brain Hypoxia-Ischemia; California; Caloric Restriction; Characteristics; cohort; Communities; cost; Development; Diet; Disease; DNA; Education; egg; Environment; Expression Profiling; Gene Expression; Goals; Harvest; Health; human disease; human subject; Hypoxia; improved; Injury; Laboratory Research; Learning; Life; Life Cycle Stages; Longevity; Marines; Memory; Metabolic; Mission; Modeling; Molecular; Monitor; Nervous System Physiology; Nervous system structure; Nervous System Trauma; novel; Photoperiod; Play; Production; programs; reproductive; Research; Research Personnel; Research Project Grants; Resistance; resistance mechanism; Resources; RNA; Role; Sales; screening; senescence; Services; Ships; Siblings; Snails; Stroke; Study models; Temperature; Time; Tissues; transcriptomics; Universities; water quality; ","National Resource for Aplysia","010952","ZRG1","Special Emphasis Panel ","7576","","24","328586","180722","","509308"
"9702792","P30","DK","5","N","04/24/2019","04/01/2019","03/31/2020","","P30DK057521","","RFA-DK-13-004","5P30DK057521-20","NIDDK:156599\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","","1895543; ","BROWN, DENNIS ;","","","","Address; Area; Award; base; Biological; Boston; Cell membrane; Cells; Cellular biology; cellular imaging; Cellular Immunology; Communities; Competence; Core Facility; design; Diabetes Mellitus; Endocrinology; Ensure; Environment; Equipment; experience; Floor; fluorescence microscope; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; Funding; Grant; Human Resources; Image; Image Analysis; imaging approach; Immunoelectron Microscopy; Immunofluorescence Immunologic; instrumentation; Islet Cell; Laboratories; Location; Maintenance; Membrane Biology; Membrane Proteins; Microscopy; Morphology; Procedures; programs; Publications; Quality Control; recruit; Research; Research Personnel; Resources; Services; Signal Transduction; Structure; success; Targeted Research; Techniques; Time; trafficking; Training; United States National Institutes of Health; Vascular Endothelial Cell; Work; ","Cell Biology Core","057521","ZDK1","Special Emphasis Panel ","7730","","20","89999","66600","","156599"
"9702797","P30","DK","5","N","04/24/2019","04/01/2019","03/31/2020","","P30DK057521","","RFA-DK-13-004","5P30DK057521-20","NIDDK:397760\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","","1911463; ","FLOREZ, JOSE CARLOS;","","","","Advisory Committees; Area; Award; Boston; Collaborations; Consultations; Diabetes Mellitus; Discipline; Endocrinology; Funding; Goals; Grant; Institutes; Institution; inter-institutional; Medicine; Monitor; new technology; Open Reading Frames; operation; Policies; programs; quality assurance; Recommendation; Research; Research Personnel; Resources; Science; Seeds; senior faculty; service delivery; Supervision; web site; ","Administrative Core","057521","ZDK1","Special Emphasis Panel ","7737","","20","296277","101483","","397760"
"9703505","P01","HL","1","N","04/22/2019","04/01/2019","03/31/2020","","P01HL146358","","PAR-18-405","1P01HL146358-01","NHLBI:514800\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","8605284; ","FONG, LOREN GI;","OLIVE, MICHELLE","","","activity-based protein profiling; Alkynes; Antibodies; Antibody Formation; Azides; base; Binding; Binding Sites; Biology; Biomedical Research; Biotin; Cells; cellular imaging; Chemicals; Chemistry; Cholesterol; Cholesterol Homeostasis; cost; crosslink; cycloaddition; Diazomethane; Disease; Electron Microscope; Electron Microscopy; Electrons; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; equipment acquisition; experience; Fab Immunoglobulins; Fluorescence Microscopy; Funding; Goals; Health; High Density Lipoproteins; high resolution imaging; Human Resources; Image; imaging modality; Insecta; instrument; Investigation; Isotopes; Label; Light; light microscopy; lipid transport; Lipids; mass spectrometer; Mass Spectrum Analysis; microscopic imaging; Microscopy; Movement; mutant; nanomachine; National Heart, Lung, and Blood Institute; novel; novel strategies; operation; Preparation; Production; Productivity; protein expression; protein profiling; Proteins; Proteolysis; Proteome; Proteomics; Protocols documentation; Reagent; Recombinant Antibody; Recombinant Proteins; recruit; Regulation; Research; Research Personnel; sample collection; sample fixation; Sampling; Scanning; Scanning Electron Microscopy; Services; Signal Transduction; Stable Isotope Labeling; Sterols; Structure; Supervision; System; Tertiary Protein Structure; Tissues; tool; trafficking; Transmission Electron Microscopy; Triglyceride Metabolism; ","Imaging, Protein Production, and Chemical Biology Core","146358","HLBP","Heart, Lung, and Blood Initial Review Group ","7804","","01","330000","184800","","514800"
"9703508","P01","HL","1","N","04/22/2019","04/01/2019","03/31/2020","","P01HL146358","","PAR-18-405","1P01HL146358-01","NHLBI:670800\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","1925069; ","TONTONOZ, PETER J;","OLIVE, MICHELLE","","","Adrenal Cortex; Adrenal Glands; Area; Arterial Fatty Streak; atherogenesis; Atherosclerosis; Binding; Binding Proteins; Biochemical; Biological; Biology; Biotin; Bone Marrow Transplantation; Cardiovascular Diseases; Cell membrane; Cells; Chemicals; Chemistry; chemoproteomics; Chimeric Proteins; Cholesterol; cholesterol control; Cholesterol Esters; Collaborations; crosslink; Data; defined contribution; Development; Disease; Electrons; Endoplasmic Reticulum; Esterification; Foam Cells; Functional disorder; Gene Targeting; Gonadal structure; HDL receptor; Health; High Density Lipoproteins; Homeostasis; Image; imaging modality; Impairment; In Vitro; in vivo; Label; Laboratories; Lesion; lipid metabolism; Lipids; live cell microscopy; macrophage; Mammalian Cell; Mass Spectrum Analysis; Measures; Mediator of activation protein; member; Membrane; Membrane Proteins; Metabolic Diseases; Metabolism; mimetics; Molecular; Movement; Mus; novel; novel strategies; particle; Pathway interactions; Physiology; Proteins; Recording of previous events; Research Personnel; response; Role; Series; Signal Pathway; SR-BI receptor; Stable Isotope Labeling; Sterols; Testing; Therapeutic Intervention; Tissues; uptake; ","Cellular cholesterol movement in cardiovascular disease","146358","HLBP","Heart, Lung, and Blood Initial Review Group ","7807","","01","430000","240800","","670800"
"9704044","U24","HL","5","N","04/22/2019","04/01/2019","03/31/2020","839","U24HL135600","","RFA-HL-17-007","5U24HL135600-03","NHLBI:962168\","OTHER RESEARCH-RELATED","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","RONDEBOSCH","SOUTH AFRICA","","","568227214","SF","1147601","UNIVERSITY OF CAPE TOWN","","7700","Project Narrative (3 sentences) There is therefore a major need for research to help develop effective therapies across the life span for Sickle Cell Disease (SCD) in all parts of the world, and longitudinal cohort studies are the most scientifically rigorous methods in understanding of, risk factors, and health and disease outcomes. High disease prevalence in sub-Saharan Africa would be expected to facilitate epidemiologic, translational, and clinical research studies on SCD, similar to Framingham Study for the heart, and this U24 application is seeking to establish a Data Coordinating Center (DCC) to be called the Sickle Africa Data Coordinating Center (SADaCC), to support the activities of a companion SCD Network in Africa. We believe that our team?s prior experience, as a coordinating center of the activities of the H3Africa Consortium and the outstanding institutional environment at the University of Cape Town and our track record in basic, translational and clinical research, and training focused on SCD in SSA augurs well to establish the most effective DCC for the SCD consortium.","11210597; ","WONKAM, AMBROISE ;","ZOU, SHIMIAN","04/01/2017","03/31/2021","Adult; Africa; Africa South of the Sahara; Basic Science; Bioinformatics; Biometry; Birth; burden of illness; Child; Clinical; Clinical Research; cohort; Companions; Consent; Country; Data Coordinating Center; data management; Data Set; Databases; Death Rate; Development; Disease; Disease Outcome; effective therapy; Ensure; Environment; epidemiology study; experience; Framingham Heart Study; Genetic; Health; Heart; Hemoglobinopathies; Hemolysis; Incidence; individual patient; Infant; Inflammation; Institution; Intervention; Longevity; Longitudinal cohort study; Maintenance; Medical; Mendelian disorder; Methods; Monitor; mortality; Neonatal Screening; Observational Study; Obstruction; Ontology; Organ; Patients; Penicillins; Phase; Point Mutation; polymerization; Prevalence; Procedures; programs; Prophylactic treatment; protocol development; Public Health; Public Policy; Regional Disease; Reporting; Research; research study; Research Training; Risk Factors; Services; Sickle Cell; Sickle Cell Anemia; Sickle Hemoglobin; sickling; skills; System; Training; Translational Research; Universities; web site; ","Developing a Sickle Africa Data Coordinating Center (SADaCC)","135600","ZHL1","Special Emphasis Panel ","","","03","894600","67568","962168",""
"9707874","R01","MH","5","N","04/24/2019","04/01/2019","03/31/2020","242","R01MH115960","","PAR-17-256","5R01MH115960-02","NIMH:86000\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","PHILADELPHIA","UNITED STATES","","02","073757627","US","1499101","CHILDREN'S HOSP OF PHILADELPHIA","PA","191462305","PROJECT NARRATIVE Tourette disorder (TD) is a poorly understood, often debilitating developmental neuropsychiatric disorder, characterized by a combination of persistent vocal and motor tics, affecting between 0.3 to 1% of people worldwide. Our international team of collaborating clinicians and geneticists has established the contribution of new (de novo) variants to TD risk and demonstrated that the continued identification of recurrent de novo variants, via sequencing of the protein coding segment of the genome, is a reliable, systematic path forward for gene discovery. Therefore, our group plans to recruit 1,000 additional parent-child simplex trios, sequence these families, identify additional high confidence TD genes, and begin the process of leveraging these molecular clues to elaborate the biological basis of TD, while making all the collected biomaterials, clinical and genomic data rapidly available to the broad scientific community.","2069586; ","BROWN, LAWRENCE W;","GITIK, MIRI","06/10/2018","03/31/2023","Affect; Asians; Attention deficit hyperactivity disorder; autism spectrum disorder; Axon; base; Biocompatible Materials; Biological; biological systems; Biology; Brain; C2 Domain; Cell model; Cells; Child; Clinical; Clinical Data; clinical research site; Code; cohort; Communities; Comorbidity; Computer Simulation; Copy Number Polymorphism; Data; Data Analyses; Data Set; Detection; Development; Dimensions; disorder risk; effective therapy; Ensure; Europe; exome sequencing; experience; Family; Family Study; Foundations; functional genomics; Funding; gene discovery; Genes; Genetic; Genetic Risk; Genome; genomic data; Genomics; Genotype; Gilles de la Tourette syndrome; Goals; Health Benefit; Human; human genomics; In Vitro; Individual; induced pluripotent stem cell; insertion/deletion mutation; International; Investigation; Journals; Lead; Link; Methods; Molecular; Motor Tics; National Institute of Mental Health; Nature; Neurites; Neurons; neuropsychiatric disorder; novel; Nucleotides; Obsessive-Compulsive Disorder; Parents; Pathologic; Peptide Sequence Determination; Phenotype; phenotypic data; Point Mutation; Population; Prevalence; proband; Process; Public Health; Publishing; rare variant; recruit; Recurrence; Reporting; Research Design; Research Personnel; Research Project Grants; Rest; risk variant; Sampling; Science; Scientist; Site; Source; South Korea; stem cell technology; Structure; success; Supervision; Testing; Time; treatment strategy; Variant; Vocal Tics; Work; ","3/7-Collaborative genomic studies of Tourette Disorder","115960","ZRG1","Special Emphasis Panel ","","","02","50000","36000","86000",""
"9712929","R25","EB","5","N","04/26/2019","04/01/2019","03/31/2020","286","R25EB023839","SCHOOLS OF ARTS AND SCIENCES","PAR-16-108","5R25EB023839-02","NIBIB:21600\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","LA JOLLA","UNITED STATES","ENGINEERING (ALL TYPES)","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","Project Narrative Design education in bioengineering often does not sufficiently cultivate team-oriented or critical thinking skills or provide clinical exposure to familiarize students with current bottlenecks in the practice of medicine. This proposed training plan will expand on a successful clinical immersion course for undergraduate bioengineering students at UC San Diego, integrate it into the senior design curriculum course flow, and develop co-learning teams with medical students to provide the vast majority of Bioengineering undergraduate students with clinically-focused senior design projects. The outcomes of this project will be a team-oriented workforce with the critical thinking skills and clinical exposure to design devices that create transformative medical devices for a wide range of health and healthcare solutions.","9677484; ","ENGLER, ADAM JEFFREY;","ERIM, ZEYNEP","06/05/2018","03/31/2023","Academic support; Accreditation; Active Learning; Address; base; Bioethics; Biomedical Engineering; Biotechnology; Cardiology; career; Clinical; clinical application; Clinical Medicine; clinical practice; clinically relevant; cohort; Collaborations; commercialization; Complement component C5; Course Content; course sequence; Critical Thinking; Data; design; Device Designs; Device or Instrument Development; Education; Educational Curriculum; Educational Models; Elements; Enrollment; Ensure; Entrepreneurship; Evaluation; Event; experience; Exposure to; Faculty; Funding; Goals; Health; Healthcare; Hospitals; Immersion Investigative Technique; Industry; innovation; instructor; Interdisciplinary Education; interest; Learning; Life; Link; Measures; Medical Device; Medical Device Designs; medical schools; medical specialties; Medical Students; Medicine; Mentors; Mentorship; Modeling; novel; Nursing Faculty; Operative Surgical Procedures; Ophthalmology; Orthopedics; Outcome; Pediatric Radiology; Phase; Physiology; Population; Process; product development; programs; prototype; Regulatory Pathway; Reporting; Science; Series; skills; Students; success; symposium; Training; Translating; undergraduate student; virtual reality; Work; ","Interprofessional Design and Entrepreneurship in Medical Devices at UC San Diego","023839","ZEB1","Special Emphasis Panel ","","","02","20000","1600","21600",""
"9718900","P30","AR","1","N","04/24/2019","04/15/2019","03/31/2020","","P30AR074992","","RFA-AR-19-002","1P30AR074992-01","NIAMS:156625\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","SAINT LOUIS","UNITED STATES","","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","","1932983; ","VEIS, DEBORAH J;","","","","Address; Adherence; Anatomy; Animal Model; Arthritis; base; Biology; bone; Cartilage; cellular imaging; Collaborations; Communities; Computer software; Consultations; cost; cost effective; Data; Disease; Disease model; Educational workshop; Electron Microscope; Ensure; Equipment; Evaluation; Exhibits; Faculty; Fees; Fostering; Fracture; Frozen Sections; Funding; Goals; Histologic; histological image; Histological Techniques; Histology; Human Resources; Image; Image Analysis; improved; Individual; insight; Knowledge; Light Microscope; Maintenance; Manuscripts; Medicine; member; Methods; Microscope; Microscopic; microscopic imaging; Microscopy; Molecular; morphometry; mouse model; Muscle; muscle form; Musculoskeletal; Musculoskeletal System; Nature; Neoplasm Metastasis; novel strategies; online resource; Outcome; Paraffin; Plastic Embedding; prevent; Protocols documentation; Publications; ranpirnase; Reporting; Reproducibility; Research; Research Personnel; Research Proposals; Resources; response; Series; Services; skeletal disorder; soft tissue; Stains; Supervision; System; Techniques; Tendon structure; Time; Tissues; Training; Training Programs; Universities; Washington; ","Musculoskeletal Histology and Morphometry Core","074992","ZAR1","Special Emphasis Panel ","5348","","01","100000","56625","","156625"
"9729351","U19","AI","2","N","04/22/2019","04/25/2019","03/31/2020","","U19AI110818","","RFA-AI-18-004","2U19AI110818-06","NIAID:688701\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","","07","623544785","US","10021177","BROAD INSTITUTE, INC.","MA","021421027","","9410597; ","SABETI, PARDIS CHRISTINE;","","","","Address; Africa; African; American; Animal Model; Antigen Presentation; Antigens; Biological Assay; Blood Circulation; Categories; Cells; Cessation of life; Clinical; combat; Communicable Diseases; Culicidae; Cytotoxic T-Lymphocytes; Data; Data Set; design; Detection; Development; Diagnostic; Disease; Ebola virus; Ecology; Ensure; Epidemiology; Evolution; experience; Expressed Sequence Tags; Genetic Transcription; Genetic Variation; Genomics; Human; human disease; Immune response; Immune system; Immune Targeting; immunogenic; immunogenicity; In Vitro; in vivo; Individual; Infection; innovation; insight; Institutes; Intervention; Investigation; Lead; Libraries; Massachusetts; Metagenomics; Methods; microbial; Molecular; Movement; National Institute of Allergy and Infectious Disease; novel; Oligonucleotides; pathogen; pathogenic virus; Pathology; Patients; Peptides; Peripheral Blood Mononuclear Cell; Policies; Population; Prevalence; priority pathogen; Public Health; Public Health Practice; Recovery; research facility; Research Personnel; Resources; response; ribosome profiling; Rodent; single-cell RNA sequencing; synthetic biology; System; Techniques; Technology; Testing; Therapeutic; therapeutic development; Ticks; Time; Tissues; Translating; Translations; transmission process; Vaccinated; Vaccine Design; vaccine development; Vaccines; vector; Viral; Viral Antigens; Viral Hemorrhagic Fevers; Viral Proteins; virology; Virus; Virus Diseases; Virus Replication; Work; Zika Virus; Zoonoses; ","Project 1 Viral Genomics: surveillance, epidemiology, host response, and viral immunogenicity","110818","ZAI1","Special Emphasis Panel ","5978","","06","431384","257317","","688701"
"9638292","U10","CA","2","N","04/26/2019","03/01/2019","02/29/2020","","U10CA180888","","RFA-CA-17-056","2U10CA180888-06","NCI:1961473\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","6765159; ","BLANKE, CHARLES D.;","","","","Advocate; Affect; American; Clinical Trials; Conceptions; cost; cost effective; Data Reporting; Development; Ensure; General Population; Goals; Investments; Leadership; Life; Malignant Neoplasms; member; Mission; operation; Patients; Population; programs; Recording of previous events; Research; Research Personnel; Safety; Southwest Oncology Group; tool; Training; treatment trial; ","SWOG Network Group Operations Center of the NCTN","180888","ZCA1","Special Emphasis Panel ","7181","","06","2415146","287033","","1961473"
"9653022","R25","HL","2","N","04/23/2019","04/24/2019","03/31/2020","837","R25HL007786","GRADUATE SCHOOLS","RFA-HL-16-008","2R25HL007786-26","NHLBI:148175\","OTHER RESEARCH-RELATED","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","FORT WORTH","UNITED STATES","NONE","12","110091808","US","6108502","UNIVERSITY OF NORTH TEXAS HLTH SCI CTR","TX","761072699","NARRATIVE The National Institutes of Health (NIH) and scientific research training communities at-large recognize the significant contribution of diverse constituencies to biomedical innovation and discovery. However, less than 8% of URMs, underserved and individuals with disabilities earn doctorates in biomedical and life sciences. Based on its 25-year success, the UNTHSC SMART program?s goal is to reduce the disproportion of URMs entering the biomedical research workforce by providing undergraduate students short-term mentor-guided research experiences.","8466423; ","JONES, HARLAN PIERRE;","MEADOWS, TAWANNA","05/10/2008","03/31/2024","Address; Advisory Committees; Advocacy; base; Behavioral Sciences; Biological Sciences; Biomedical Research; career; Career Choice; career preparation; cohort; Communities; Cultural Diversity; Disabled Persons; Diverse Workforce; education research; Enrollment; Ensure; experience; Faculty; faculty mentor; Feedback; Funding; Future; Goals; Health; Health Professional; Health Sciences; improved; innovation; Institution; Knowledge; Light; Mentors; Minority Participation; Mission; National Heart, Lung, and Blood Institute; peer coaching; peer networks; programs; recruit; Research; Research Institute; Research Training; Schools; Science; skills; student training; success; Talents; Texas; Training; Training Programs; undergraduate education; undergraduate student; Underrepresented Minority; Underserved Population; United States National Institutes of Health; Universities; Work; ","UNTHSC Short-Term Research Education Program","007786","ZHL1","Special Emphasis Panel ","","","26","137199","10976","148175",""
"9658575","R01","MH","5","N","04/22/2019","04/01/2019","03/31/2020","242","R01MH070727","","PA-13-302","5R01MH070727-15","NIMH:611699\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","NASHVILLE","UNITED STATES","","05","965717143","US","8721001","VANDERBILT UNIVERSITY","TN","372407749","PUBLIC HEALTH RELEVANCE:  The objective of this grant is to study the role of BDNF in the hippocampus in mediating antidepressant responses in mice. Based on our preliminary data presented in this application, we will examine the role of the eEF2 signaling pathway in mediating fast acting antidepressant responses upstream of BDNF as well as the impact of BDNF specifically in the hippocampus on rapid antidepressant responses. These studies will use molecular, cellular, behavioral, and electrophysiological approaches to investigate the signaling pathways involved in mediating fast acting antidepressant responses, in the hopes of developing novel antidepressants with rapid onset of clinical efficacy.","3119042; ","MONTEGGIA, LISA M;","WINSKY, LOIS M","09/21/2018","03/31/2021","Affinity; Animal Model; antidepressant effect; Antidepressive Agents; base; Behavioral; behavioral response; Brain; Brain-Derived Neurotrophic Factor; calmodulin-dependent protein kinase III; Chemosensitization; Clinical; clinical efficacy; clinically relevant; Data; Development; Electrophysiology (science); Equilibrium; experimental study; Funding; Gene Transfer; Glutamates; Grant; Hippocampus (Brain); In Vitro; in vivo; inhibitor/antagonist; insight; Ketamine; knock-down; Knockout Mice; Link; Mediating; Mediator of activation protein; Memantine; Mental Depression; Messenger RNA; Molecular; Mus; N-Methyl-D-Aspartate Receptors; Neuronal Plasticity; Neurons; neurotrophic factor; Neurotrophic Tyrosine Kinase Receptor Type 2; novel; Peptide Elongation Factor 2; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Prosencephalon; Protein Dephosphorylation; Proteins; public health relevance; Receptor Activation; Regulation; Repression; response; Rest; Role; Signal Pathway; Signal Transduction; Synapses; Transcript; Transducers; Translations; Viral; Wild Type Mouse; Work; ","ANTIDEPRESSANTS & INTRACELLULAR SIGNALING LINKED TO BDNF","070727","ZRG1","Special Emphasis Panel ","","","15","389835","221864","611699",""
"9664046","I01","VA","1","N","04/24/2019","04/01/2019","03/31/2020","999","I01CX001923","","RFA-BX-18-011","1I01CX001923-01","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","COLUMBIA","UNITED STATES","","02","086371846","US","10018661","VETERANS HEALTH ADMINISTRATION","SC","292091638","The collaborative MERIT proposal hypothesizes that hyperinflammatory profiles in Gulf War Veterans could be due to exposures to chemical and/or environmental stressor and multiple vaccinations experienced by Veterans during the Gulf War, which sensitizes the affected veterans to the development of Gulf War Veterans Illness. The present project led by Saurabh Chatterjee (Project 2) is designed in both rodent models and veterans? cohort to test the hypothesis that chemical stressors, like insecticides and nerve gas antidotes routinely used during deployment, may induce gastrointestinal dysbiosis (gut microbiome changes) and metabolomic alterations via modulations of the gut inflammasome. These microbiome changes may lead to disruptions in barrier functions thus allowing continuous penetration of endotoxin/inflammatory mediators into the brain. These events may ultimately induce a sustained hyperinflammatory state while inflammasome blockers/probiotics may attenuate the above responses by blocking dysbiosis.","10454728; ","CHATTERJEE, SAURABH ;","","04/01/2019","03/31/2023","Affect; Animal Model; Antidotes; arm; Attenuated; attenuation; Autoantibodies; Autoimmune Diseases; Award; base; Biological Models; Biological Response Modifiers; Blood; Brain; Bromine; Butyrates; Cell Death; Chemical Exposure; Chemicals; Chemistry; Clinical; cohort; Collaborations; Complex; Coupled; cytokine; Data; design; Development; Diagnosis; Disease; dysbiosis; Endotoxemia; Endotoxins; environmental stressor; Etiology; Event; experience; Experimental Models; Exposure to; Fatigue; Female; fluorophosphate; Future; gastrointestinal; Generations; Genes; Genetic Polymorphism; Genetic Variation; Goals; Gulf War; gut microbiome; health administration; HMGB1 gene; Human; Hydroxybutyrates; Immune; immune activation; Immune response; Immune system; Immunity; Immunologic Tests; Immunologics; Immunotherapeutic agent; Impaired cognition; Individual; Inflammasome; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; inhibitor/antagonist; innovation; Insecticides; insight; Interdisciplinary Study; interest; Interleukin-1 beta; Intestines; Isoprostanes; Joints; Knock-out; Knockout Mice; Lead; Leptin; Link; Lipid Peroxides; Mediating; Mediator of activation protein; Medical center; metabolomics; Metagenomics; Microbiology; microbiome; microbiome alteration; Molecular; Mood Disorders; mouse model; multidisciplinary; Mus; nerve gas; neuroinflammation; Neurons; Neurosciences; Nitrates; novel; novel therapeutic intervention; Organ failure; Outcome Study; Oxidative Stress; Pain; Pathologic; Pathology; Pathway interactions; Pattern; Pattern recognition receptor; Penetration; Permethrin; Pesticides; Pharmacology; Phenotype; Plasma; Play; pre-clinical research; Probiotics; programs; Proteins; psychological stressor; Public Health Schools; pyridostigmine; Reaction; Receptor Activation; Receptor Cell; relating to nervous system; Research; Research Personnel; Research Project Grants; response; Rodent; Rodent Model; Role; Sampling; Science; Small Intestines; Stimulus; Stress; stressor; Symptoms; Synaptic plasticity; Testing; Therapeutic Effect; Therapeutic Studies; tissue degeneration; Toxic Environmental Substances; Toxin; Translating; translational study; Translations; Uranium; Vaccination; Vaccines; Veterans; Vision; Work; ","CMA: Immune/Inflammatory Priming in Exacerbating Responses to GWVI Stressors: Implications for GWVI Treatments","001923","ZRD1","Special Emphasis Panel ","","","01","","","",""
"9664689","D43","TW","5","N","04/27/2019","03/01/2019","02/29/2020","989","D43TW010530","SCHOOLS OF PHARMACY","PAR-14-193","5D43TW010530-03","FIC:115996\NIAID:100000\","OTHER RESEARCH-RELATED","2019","FOGARTY INTERNATIONAL CENTER","","Chicago","UNITED STATES","PHARMACOLOGY","07","098987217","US","577703","UNIVERSITY OF ILLINOIS AT CHICAGO","IL","606124305","Vietnam is located in a region that accounts for 58% of the world's TB cases, and an estimated 137,000 Vietnamese are infected with TB per year (5,000 of which acquire drug-resistant TB). In the current proposal, we aim to enhance and strengthen a research training program between the University of Illinois at Chicago (UIC), the Institute of Marine Biochemistry at the Vietnam Academy of Science and Technology (IMBC-VAST), and the National Institute of Hygiene and Epidemiology (NIHE) in Hanoi, Vietnam. We aim to enhance host country research capacity that focuses on the discovery and development of antibiotic leads for TB.","9876436 (contact); 11253414; ","MURPHY, BRIAN THACHER (contact); PHAM, CUONG VAN;","SINA, BARBARA J","06/01/2017","02/28/2022","Academy; AIDS/HIV problem; Antibiotics; base; Basic Science; Biochemistry; Biodiversity; Biological Assay; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chicago; Clinical; Collaborations; Complement; Country; Development; Disease; Drug resistance in tuberculosis; Epidemiology; Foundations; Funding; HIV Seropositivity; Hygiene; Illinois; In Vitro; Infrastructure; Institutes; Institution; Lead; Marines; Medical; Mycobacterium tuberculosis; Natural Resources; Pathogenicity; Pharmaceutical Preparations; Plants; post-doctoral training; pre-doctoral; programs; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Science; Scientist; screening; screening program; Students; success; System; Technology; Training; Training and Education; Training Programs; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; Vietnam; Work; World Health Organization; ","Enhancing basic and translational TB research in northern Vietnam","010530","ZRG1","Special Emphasis Panel ","","","03","211881","4115","215996",""
"9665145","U19","AI","1","N","04/22/2019","04/01/2019","03/31/2020","","U19AI142636","","PAR-15-330","1U19AI142636-01","NIAID:605905\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAN ANTONIO","UNITED STATES","","23","007936834","US","7660801","TEXAS BIOMEDICAL RESEARCH INSTITUTE","TX","782450549","","1872914; ","RUPRECHT, RUTH MARGRIT;","","05/01/2019","04/30/2024","Acquired Immunodeficiency Syndrome; Adjuvant; African; Animal Model; Animals; Antibody Formation; Antigens; Autopsy; capsule; Cells; Characteristics; Chinese People; Cold Chains; combat; Control Groups; design; Detection; Developing Countries; Dose; efficacy study; efficacy testing; Enteral; Epidemic; experimental study; Female; Follow-Up Studies; Formulation; Generations; Hand; HIV; HIV Envelope Protein gp41; HIV-1; human male; ileum; Immunization; Immunize; immunogenic; immunogenicity; improved; influenzavirus; innovation; Intramuscular; Isotopes; Label; Lead; liquid formulation; Liquid substance; Macaca mulatta; man; Membrane; Microscopy; Modeling; Monitor; Morbidity - disease rate; mortality; Mucous Membrane; Needles; novel; novel strategies; novel vaccines; Oral; parenteral administration; particle; Peptides; Plant Resins; Powder dose form; prevent; programs; Radioactive Tracers; Recombinants; rectal; Refrigeration; Regimen; Route; Scanning; simian human immunodeficiency virus; SIV; Small Intestines; Solid; Stomach; Surface; Systemic infection; Tablets; Testing; Time; Tissues; TLR7 gene; Tracer; transmission process; uptake; Vaccination; vaccine delivery; vaccine development; vaccine efficacy; vaccine evaluation; Vaccines; Virosomes; Virus; Virus-like particle; Woman; Work; ","Vaccine immunogenicity and efficacy in the rhesus macaque/SHIV model","142636","ZAI1","Special Emphasis Panel ","6243","","01","499564","106341","","605905"
"9665198","I01","VA","1","N","04/26/2019","04/01/2019","03/31/2020","999","I01CX001547","","RFA-CX-18-004","1I01CX001547-01A2","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","PORTLAND","UNITED STATES","","03","089461255","US","481073","PORTLAND VA MEDICAL CENTER","OR","972392964","Parkinson?s disease (PD) is the second most common neurodegenerative disease in the United States (US), and is more common in older men, affecting 2% of Veterans. Approximately 50,000 obtain care for PD through the Veteran?s health care system. Patients with PD are treated with drugs that augment dopamine neurotransmission. An unfortunate common side effect of drug treatment is levodopa induced dyskinesias (LID). These purposeless, unwanted jerking or wiggling movements cause reduced quality of life as it worsens in severity over the years. Treatment options are limited and include expensive deep brain surgical procedures for some. Animal models of LID show statins delay the onset of dyskinesia and then retard its progression in severity over time. Our project will study whether statin intake during levodopa initiation and continuation prevents the inevitable worsening of LID over time and thus preserves quality of life in PD.","8162653; ","CHUNG, KATHRYN ANNE;","","04/01/2019","03/31/2023","Adverse drug effect; Adverse effects; Affect; Amantadine; Animal Model; Biological Markers; Brain; Caring; CD3 Antigens; Characteristics; Chorea; Clinical Treatment; cohort; Complication; cost; Coupled; Data; Databases; Deep Brain Stimulation; design; Development; Diagnosis; Disease; Dopamine; Dose; Dyskinetic syndrome; Fright; Functional disorder; Future; Gait abnormality; Goals; Healthcare Systems; Hydroxymethylglutaryl-CoA reductase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infusion procedures; Ingestion; instrument; Intake; Interruption; Intravenous; Investigation; Knowledge; Lead; Levodopa; Lymphocyte; MAPK3 gene; Measurement; Measures; Methods; Modeling; Molecular; Movement; MS4A1 gene; Neurodegenerative Disorders; neurotransmission; novel; older men; Operative Surgical Procedures; Parkinson Disease; Parkinsonian Disorders; Patients; Pharmaceutical Preparations; Pharmacotherapy; prevent; Prevention strategy; Preventive; Primary Prevention; Primates; Process; prospective; Quality of life; Rattus; Retrospective cohort; Retrospective cohort study; Rodent; Secondary Prevention; Secondary to; Severities; Signal Transduction; Simvastatin; Symptoms; Testing; Therapeutic; Time; Translating; treatment trial; Tremor; United States; Veterans; Work; ","Preventing levodopa induced dyskinesia in Parkinson?s Disease with Statins","001547","ZRD1","Special Emphasis Panel ","","A2","01","","","",""
"9665273","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:270616\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","8652214; ","GRIFFITH, DEREK M;","","","","20 year old; Adoption; Affect; African American; Age; age group; attentional control; Attitude; base; Behavior; Behavior Therapy; Behavioral; Belief; Biological; Biological Factors; Biology; Blood Glucose; Body fat; Body Weight decreased; Chronic Disease; Communities; comparative efficacy; Control Groups; Data; demographics; design; diabetes risk; Diet; disorder risk; Eating; Effectiveness; Effectiveness of Interventions; energy balance; Ethnic Origin; Etiology; Evaluation; experience; Focus Groups; Gender; Genetic; Glycosylated hemoglobin A; Goals; Health; Health behavior; Health Communication; Healthy Eating; Heterogeneity; improved; Individual; Internet; Intervention; Intervention Trial; Latino; Lipids; Maintenance; Measures; Mediator of activation protein; men; men's group; middle age; Monitor; Morbidity - disease rate; mortality; Motivation; Obesity; Outcome; Overweight; Pattern; personalized intervention; Persons; Phenotype; Physical activity; physical inactivity; Physiological; Pilot Projects; Play; population health; precision medicine; psychologic; psychosocial; Race; racial and ethnic; Randomized; Randomized Controlled Trials; Research; Resources; Risk; Risk Behaviors; Role; sedentary lifestyle; Self Efficacy; Shapes; social; Social support; Surface; Testing; Text; Training and Education; Treatment Efficacy; wearable device; Weight; weight loss intervention; Woman; Work; ","Project-3 Tailored behavioral intervention for overweight African Americans and Latino men","010722","ZMD1","Special Emphasis Panel ","8206","","04","254375","56599","","270616"
"9665513","R01","HL","5","N","04/25/2019","03/01/2019","02/29/2020","838","R01HL127393","SCHOOLS OF MEDICINE","PA-13-302","5R01HL127393-04","NHLBI:423750\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NEW YORK","UNITED STATES","INTERNAL MEDICINE/MEDICINE","12","060217502","US","1514803","WEILL MEDICAL COLL OF CORNELL UNIV","NY","100654805","PUBLIC HEALTH RELEVANCE: Smoking induces airway epithelium remodeling (AER) phenotypes relevant to chronic obstructive pulmonary disease (COPD), the major smoking-induced lung disorder, for which no disease-modifying targeted therapies that affect mortality are available. This study is focused on amphiregulin (AREG), an epidermal growth factor (EGF) receptor (EGFR) ligand, which, based on preliminary data, is induced in the AER areas in healthy smokers and smokers with COPD and promotes the development of major COPD-relevant smoking-associated AER by acting on airway basal cells (BC) stem/progenitor cells in a manner distinct from the classical EGFR ligand EGF. The goal of this study is to identify the mechanisms that underlie smoking-induced up-regulation of AREG and AREG-mediated AER in the human airway epithelium, and develop the strategies to prevent or suppress smoking-induced COPD- relevant AER via inhibition of AREG up-regulation and signaling in airway BC stem/progenitor cells.","11442011; ","SHAYKHIEV, RENAT ;","POSTOW, LISA","03/15/2016","02/29/2020","Affect; Air; airway epithelium; airway remodeling; Amphiregulin; Architecture; Area; Basal Cell; Basal Cell Hyperplasia; base; Biochemical; Biological Assay; Cell Differentiation process; Cell surface; Cells; Chronic Obstructive Airway Disease; cigarette smoke; cigarette smoking; Cilia; Data; Development; Disease; Elements; Epidermal Growth Factor; Epidermal Growth Factor Receptor; Epithelial; exposure to cigarette smoke; Generations; genome-wide; Goals; Human; Hyperplasia; In Vitro; in vivo; inhibitor/antagonist; Intercellular Junctions; Knowledge; Ligands; Liquid substance; Lung diseases; Maintenance; Mediating; Mediator of activation protein; Modeling; Molecular; mortality; Mucous body substance; Mus; non-smoker; novel therapeutic intervention; novel therapeutics; Pathogenesis; Pathway interactions; Permeability; Pharmacology; Phenotype; prevent; public health relevance; receptor; Receptor Activation; Receptor Signaling; Role; Signal Transduction; Site; Smoker; Smoking; Squamous Differentiation; Squamous Metaplasia; stem; Stem cells; targeted treatment; Testing; Tight Junctions; transcriptome; Transforming Growth Factor beta; Up-Regulation; ","Amphiregulin-driven COPD-relevant Remodeling of Human Airway Epithelium","127393","LCMI","Lung Cellular, Molecular, and Immunobiology Study Section ","","","04","250000","173750","423750",""
"9667980","F32","NS","5","N","04/25/2019","03/02/2019","03/01/2020","853","F32NS105350","SCHOOLS OF MEDICINE","PAR-16-458","5F32NS105350-03","NINDS:60610\","TRAINING, INDIVIDUAL","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","STANFORD","UNITED STATES","NEUROLOGY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943041222","The nervous system uses neural circuits to generate cognition and behavior. A deeper understanding of how functional neural circuits are assembled may facilitate regenerative therapies for spinal cord injury or stroke, and may help optimize brain stimulation therapy to treat mental disorders. This proposal will characterize the role of early patterned spontaneous neuronal activity in locomotor circuit formation, a conserved, important, but poorly understood aspect of circuit assembly.","10562970; ","CARREIRA-ROSARIO, ARNALDO ;","CHEN, DAOFEN","08/01/2018","05/01/2020","Address; Affect; Behavior; Biological Assay; Brain; calcium indicator; Cell physiology; cell type; Cognition; Collection; Computer Analysis; connectome; Cues; design; Development; Drosophila genus; Elements; Embryo; Event; Exhibits; Goals; hatching; Image; Individual; Injury; insight; Interneurons; Invertebrates; Locomotion; Mammals; Mental disorders; Molecular; Motor; Motor Neurons; Nervous system structure; neural circuit; Neuraxis; neuronal circuitry; Neurons; Neurophysiology - biologic function; optogenetics; Pattern; Periodicity; Population; Proxy; Reagent; regenerative therapy; Role; Spinal cord injury; Stroke; Synapses; Synaptic Membranes; synaptogenesis; System; Testing; Time; time use; tool; Transmission Electron Microscopy; Vertebrates; virtual; ","The role of patterned spontaneous network activity in motor circuit activity","105350","ZNS1","Special Emphasis Panel ","","","03","60610","","60610",""
"9669073","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:663762\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","1903126; ","LEWIS, ROBERT E.;","","","","Advisory Committees; Biology; Biotechnology; career; career development; Clinical; cohort; Communication; Complex; Data Analyses; design; Detection; Development; Development Plans; Disease; Drug Industry; Effectiveness; Ensure; Environment; Etiology; experience; Experimental Designs; experimental study; Faculty; Fostering; Funding; Generations; Goals; Grant; Health; Human; human disease; improved; Infrastructure; innovation; interest; Investments; knowledge translation; Laboratories; Lead; Leadership; member; Mentors; Mission; Molecular; Molecular Target; Nebraska; novel strategies; Outcome; Performance; Pilot Projects; Pre-Clinical Model; Procedures; Program Research Project Grants; programs; recruit; Reporting; Research; Research Personnel; Research Project Grants; Resources; Scientist; Secure; senior faculty; Series; skills; small molecule; Students; System; Talents; Teacher Professional Development; tool; Training; Training Support; Universities; Update; Validation; voucher; Work; ","Administrative Core","121316","ZGM1","Special Emphasis Panel ","8783","","02","435253","228509","","663762"
"9669083","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:279075\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","11328261; ","GHOSAL, GARGI ;","","","","Adult; Alleles; C-terminal; cancer cell; Cancer cell line; cancer therapy; Cell Aging; Cell Death; Cell Proliferation; Cell Survival; Cells; chemotherapy; Cleaved cell; combinatorial; crosslink; design; Development; DNA; DNA biosynthesis; DNA Damage; DNA lesion; DNA Repair Gene; DNA Repair Pathway; DNA replication fork; DNA-protein crosslink; early onset; Embryo; Enzymes; Epithelium; Etoposide; Excision; Exposure to; Formaldehyde; Genomic Instability; high throughput screening; homologous recombination; In Vitro; in vivo; Knockout Mice; Lead; Lesion; Liver; LoxP-flanked allele; Malignant neoplasm of liver; Malignant Neoplasms; Mediating; Metalloproteases; migration; Molecular; Molecular Target; Monoubiquitination; Mosaicism; mouse model; Mus; mutant; Mutation; N-terminal; Nebraska; nuclease; Nucleotide Excision Repair; Pathway interactions; Patients; Peptide Hydrolases; Pharmaceutical Preparations; Phenotype; Physiological; Post-Translational Protein Processing; prevent; Primary carcinoma of the liver cells; Progeria; protein function; Proteins; Proteolysis; Radiation therapy; Regulation; repaired; response; Role; Site; small molecule inhibitor; Susceptibility Gene; Syndrome; Therapeutic; Topoisomerase; Topoisomerase Inhibitors; tumor growth; Tumor Suppressor Proteins; tumorigenesis; tyrosyl-DNA phosphodiesterase; ubiquitin-protein ligase; Ubiquitination; ultraviolet damage; UV induced DNA damage; virtual; Xenograft procedure; ","Spartan Protease Repairs DNA-Protein Cross-Links (DPCs) and Prevents DPC-Induced Oncogenesis","121316","ZGM1","Special Emphasis Panel ","8787","","02","183000","96075","","279075"
"9670793","R35","GM","5","N","04/23/2019","04/01/2019","03/31/2020","859","R35GM118078","BIOMED ENGR/COL ENGR/ENGR STA","RFA-GM-16-002","5R35GM118078-04","NIGMS:570653\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","ENGINEERING (ALL TYPES)","07","049435266","US","10001093","BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)","MA","022151390","PUBLIC HEALTH RELEVANCE: Our research focuses on molecular recognition, primarily protein-protein interactions and the binding properties of proteins. The main goals are to develop reliable and robust computational methods that are based on rigorous biophysical principles and have the potential for substantially improving the efficiency of biomedical and pharmaceutical research, and to implement them as web-based servers to be validated by broad user communities.","1968362; ","VAJDA, SANDOR ;","LYSTER, PETER","04/06/2016","03/31/2021","Address; Algorithms; Area; base; Binding; Binding Sites; Biophysics; Communities; Complex; Computing Methodologies; cost; Crowding; Docking; Drug Targeting; experimental analysis; experimental study; flexibility; follow-up; Free Energy; Goals; Homology Modeling; Hot Spot; improved; Laboratories; Ligands; Methodology; Methods; Modeling; Molecular Probes; molecular recognition; molecular size; novel strategies; Online Systems; Paper; Peptides; Pharmacologic Substance; Property; protein protein interaction; Protein Region; Proteins; Proteome; public health relevance; Reporting; Research; Sampling; screening; Side; Solvents; Structure; Surface; System; Testing; Validation; virtual; ","Analysis and prediction of molecular interactions","118078","ZGM1","Special Emphasis Panel ","","","04","345850","224803","570653",""
"9670932","U01","CA","1","N","04/23/2019","04/23/2019","03/31/2020","396","U01CA235747","SCHOOLS OF MEDICINE","PAR-16-344","1U01CA235747-01","NCI:814050\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","NEW HAVEN","UNITED STATES","INTERNAL MEDICINE/MEDICINE","03","043207562","US","9420201","YALE UNIVERSITY","CT","065208327","PROJECT NARRATIVE Thoracic malignancies are the principal source of cancer related deaths due to the rapid metastatic spread of lung cancer cells. Even in patients with metastatic disease treated with effective targeted therapies resistance eventually emerges and the lung cancer further metastasizes. Our novel multi-disciplinary approach proposes to generate new human patient-derived lung cancer models to study the molecular causes of these phenomena and will reveal fundamental new principles in cancer biology, drug resistance, and the tumor microenvironment.","10640101; 2186003 (contact); ","NGUYEN, DON X; POLITI, KATERINA ABIGAIL (contact);","ESPEY, MICHAEL G","04/23/2019","03/31/2024","Address; Affect; Area; base; Biological; Biology; Biopsy; Brain; Bypass; Cancer Biology; cancer cell; Cancer Etiology; Cancer Model; Cancer Patient; Cell Line; Cells; Cessation of life; Clinical; Data; Development; Disease; Disseminated Malignant Neoplasm; Drug resistance; Epidermal Growth Factor Receptor; Erlotinib; Evolution; Exhibits; Extracellular Matrix; Gefitinib; Generations; Heterogeneity; Histologic; Human; Immunotherapy; Implant; insight; interdisciplinary approach; Knowledge; Lead; Light; Link; Liver; Location; Lung Adenocarcinoma; Malignant neoplasm of lung; Malignant neoplasm of thorax; Malignant Neoplasms; Measures; Mediator of activation protein; Modeling; Molecular; Molecular Profiling; molecular targeted therapies; mutant; Mutation; Nature; Neoplasm Metastasis; neoplastic cell; novel; novel therapeutic intervention; novel therapeutics; Organoids; Outcome; Pathway interactions; patient subsets; Patients; Pattern; Pharmacology; Phenotype; Play; Pre-Clinical Model; prevent; Principal Investigator; Process; programs; Property; Refractory; Regimen; Relapse; Research; Resistance; resistance mechanism; Resources; response; Role; Sampling; Series; Signal Pathway; Site; Source; Specimen; subcutaneous; targeted treatment; Testing; therapy resistant; Tissues; translational research program; tumor; tumor microenvironment; tumor xenograft; Tyrosine Kinase Inhibitor; Xenograft procedure; ","Uncovering the Biology of Resistance to Tyrosine Kinase Inhibitors in EGFR Mutant Lung Cancer Patient-Derived Models.","235747","ZCA1","Special Emphasis Panel ","","","01","486000","328050","814050",""
"9671400","R01","DK","5","N","04/25/2019","04/01/2019","03/31/2020","847","R01DK105263","SCHOOLS OF MEDICINE","PA-13-302","5R01DK105263-04","NIDDK:447836\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","STANFORD","UNITED STATES","INTERNAL MEDICINE/MEDICINE","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943041222","PUBLIC HEALTH RELEVANCE: Chronic pancreatitis (CP) remains a challenging clinical problem and despite its disease burden, therapy remains supportive at best. Generally chronic pancreatitis is accepted as an irreversible fibrotic disease and current chronic pancreatitis management focus in dealing with the complications associated with the disease, as there is no active therapy for the condition that would alter the natural course of the disease. Our study proposes to examine the immune responses associated with progression and/or development of chronic pancreatitis in order to better understand pathogenic mechanisms that lead to disease progression. Using experimental models of chronic pancreatitis, we take advantage of the plasticity of immune cells and associated immune responses to interfere with chronic pancreatitis progression pathways. Our preliminary results identify some of the important immune mechanisms involved and highlight the possibility of interfering with these immune pathways to confer protection against chronic pancreatitis.","7931431; ","HABTEZION, AIDA ;","SERRANO, JOSE","04/05/2016","03/31/2021","Acinar Cell; acute pancreatitis; Affect; Animal Model; Automobile Driving; Behavior; burden of illness; Cell Communication; Cell physiology; Cells; Chronic; chronic abdominal pain; chronic pancreatitis; Clinical; clinically significant; Coculture Techniques; Collagen; cytokine; Data; Development; Disease; Disease Progression; driving force; Endocrine; Experimental Models; Extracellular Matrix Degradation; Extracellular Matrix Proteins; fibrogenesis; Fibronectins; Fibrosis; Goals; Host Defense; Human; Immune; Immune response; Immune system; In Vitro; in vivo; Inflammation; injured; innovation; Islet Cell; Lead; Leukocytes; Lipopolysaccharides; macrophage; Malignant neoplasm of pancreas; Mediating; Methods; monocyte; novel; novel therapeutics; operation; Operative Surgical Procedures; Pancreas; pancreas development; Pathogenicity; Pathway interactions; Patients; Phenotype; Play; Process; public health relevance; Research; Risk Factors; Role; Source; Specimen; stellate cell; Stenosis; System; T-Lymphocyte; Testing; Therapeutic; Therapeutic Agents; Tissues; Transgenic Animals; Wound Healing; ","Role of immune cells in chronic pancreatitis","105263","ZRG1","Special Emphasis Panel ","","","04","273422","174414","447836",""
"9671908","R01","EB","5","N","04/24/2019","03/01/2019","02/29/2020","286","R01EB020683","BIOMED ENGR/COL ENGR/ENGR STA","PA-13-302","5R01EB020683-04","NIBIB:400000\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","NORFOLK","UNITED STATES","ENGINEERING (ALL TYPES)","03","041448465","US","6249601","OLD DOMINION UNIVERSITY","VA","235080369","PUBLIC HEALTH RELEVANCE: The planned brain tumor segmentation (BTS) tool in this study will provide neuroradiology practice with an accurate, objective, and consistent means for evaluating and interpreting tumors. This advancement, in turn, will (i) have an immediate impact on radiotherapy planning and follow-up treatment; (iii) enhance patients' eligibility for clinical trials; and (ii) provide a large community of end-users with methods for advanced image analysis of a variety of brain tumors and related neuroimaging studies.","6600821; ","IFTEKHARUDDIN, KHAN M;","DUAN, QI","06/01/2016","02/29/2020","Address; Adult; Algorithms; Atlases; base; Base of the Brain; Bayesian Analysis; Biology; Brain; brain abnormalities; Brain Neoplasms; Brain scan; brain tissue; Central Nervous System Neoplasms; Child; Childhood; Classification; Clinical; clinical application; Clinical Trials; Cognitive; Communities; Computational algorithm; Computer Simulation; Computer software; Cyst; Data; Data Set; Diagnosis; Diffuse; Disease; Early Diagnosis; Early treatment; Edema; Eligibility Determination; Ensure; Equipment; Excision; Family; follow-up; Fractals; Goals; Grant; Growth; Histopathology; Image; Image Analysis; image guided radiation therapy; image guided therapy; improved; Knowledge; Label; Lesion; Literature; Magnetic Resonance Imaging; Malignant neoplasm of brain; Malignant neoplasm of central nervous system; Malignant Neoplasms; Medical Imaging; Methods; Modeling; mortality; MRI Scans; multimodality; Multiple Abnormalities; National Cancer Institute; Necrosis; neuroimaging; Noise; Normal tissue morphology; novel; Operative Surgical Procedures; Outcome; patient population; Patients; Pediatric Hospitals; Performance; Philadelphia; programs; Protocols documentation; public health relevance; quantitative imaging; Radiation therapy; Research; Research Project Grants; Residual Tumors; Residual volume; Resources; Risk; Risk stratification; Sensitivity and Specificity; Signal Transduction; Slide; Testing; Texture; Time; Tissues; tool; Treatment outcome; tumor; Tumor Tissue; Tumor Volume; United States National Institutes of Health; Variant; ","Quantitative Image Modeling for Brain Tumor Analysis and Tracking","020683","BMIT","Biomedical Imaging Technology Study Section ","","","04","301998","98002","400000",""
"9672447","P30","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P30ES009089","","RFA-ES-17-003","5P30ES009089-21","NIEHS:185774\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","NEW YORK","UNITED STATES","","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","","2409522; ","FACTOR-LITVAK, PAM R.;","","","","Academic Medical Centers; Address; Area; Attention; Award; Biometry; Clinical Research; Communities; Complex; computer infrastructure; computerized tools; Computing Methodologies; computing resources; Conceptions; Consultations; Core Facility; cost effective; Data; Data Analyses; Data Analytics; Data Collection; data management; Data Sources; data warehouse; design; Development; Doctor of Philosophy; Effectiveness; Ensure; Environmental Health; experimental study; Faculty; Fostering; Funding; Geographic Information Systems; Grant; Health Sciences; Imagery; Information Dissemination; Institutional Review Boards; instrument; Integrative Medicine; Investigation; Link; Manuscripts; Measurement; member; Methods; neglect; Observational Study; Online Systems; Outcome; patient oriented; Pilot Projects; Policies; Population Research; Postdoctoral Fellow; Preparation; programs; Public Domains; Publications; Reporting; Reproducibility; Research; Research Design; Research Personnel; Resources; Science; Services; sound; Statistical Data Interpretation; Statistical Models; Structure; Students; success; System; tool; Training; Translational Research; United States National Institutes of Health; Work; ","Study Design and Data Analytics Facility Core","009089","EHS","Environmental Health Sciences Review Committee ","7565","","21","116109","69665","","185774"
"9672576","K01","MH","5","N","04/26/2019","04/01/2019","03/31/2020","242","K01MH107787","","PA-14-044","5K01MH107787-04","NIMH:171666\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","BELMONT","UNITED STATES","","05","046514535","US","1876801","MCLEAN HOSPITAL","MA","024781064","PUBLIC HEALTH RELEVANCE: Cognitive rigidity is a major cognitive symptom in autism spectrum disorders, schizophrenia, some anxiety disorders and mood disorders, which together affect more than 30 million people in the US alone. However, a systematic study of the brain system underlying adaptive cognitive flexibility or the disruptions in this system leading to cognitive rigidity in neuropsychiatric disorders has not been undertaken. The proposed research aims to determine some ground-level brain processes that will form the foundation for future studies of the brain circuitry of cognitive flexibility, as well as the development of therapeutic strategies to treat cognitive rigidity.","10807083; ","ENGIN, ELIF ;","DRISCOLL, JAMIE","04/01/2016","03/31/2020","Address; Affect; Affective; Anxiety; Anxiety Disorders; Applications Grants; Area; autism spectrum disorder; Autistic Disorder; Award; base; Behavior; Behavioral; Behavioral Genetics; behavioral pharmacology; Brain; brain circuitry; career; career development; career networking; Characteristics; Cognitive; cognitive rigidity; Collection; Communication Research; Complex; Computer Simulation; conditioned fear; Data; dentate gyrus; Detection; Electrophysiology (science); entorhinal cortex; Equilibrium; Ethical Issues; experience; Extinction (Psychology); Failure; flexibility; Foundations; Freezing; Fright; Future; Genetic; Goals; Grant; Health; hippocampal pyramidal neuron; Hippocampus (Brain); Histologic; Impairment; improved; In Situ Hybridization; in vivo; Investigation; Knock-out; Knowledge; knowledge base; Laboratories; Laboratory Research; Lead; Leadership; Learning; Link; Location; Measures; Mediating; Memory; memory consolidation; Memory impairment; memory retrieval; Mental Depression; Mentored Research Scientist Development Award; Mentors; Modeling; Molecular; Mood Disorders; mouse model; Mus; neural model; Neurobehavioral Manifestations; neuromechanism; neurophysiology; neuropsychiatric disorder; Occupations; optogenetics; Oral; Outcome; Outcome Study; Output; Pathologic; Pattern; Pharmacology; Phase; Phenotype; Play; Post-Traumatic Stress Disorders; Preparation; Process; public health relevance; Publications; Pyramidal Cells; receptor; Research; Research Project Grants; Research Technics; Research Training; response; responsible research conduct; Retrieval; Rewards; Rodent; Role; Schizophrenia; skills; Structure; Symptoms; System; Techniques; Testing; Therapeutic; therapeutic development; Thinking; Training; Translational Research; Update; Writing; ","Intrahippocampal dynamics underlying cognitive rigidity","107787","LAM","Neurobiology of Learning and Memory Study Section ","","","04","158950","12716","171666",""
"9672894","U19","AI","5","N","04/25/2019","04/01/2019","03/31/2020","855","U19AI089688","SCHOOLS OF ARTS AND SCIENCES","RFA-AI-15-056","5U19AI089688-10","NIAID:1345565\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","CHEMISTRY","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","The Malaria Evolution in South Asia International Center of Excellence for Malaria Research (MESA-ICEMR) will study the changing nature of malaria parasites in India. We are particularly interested in initiation of drug resistance as well as the pathways and ecological barriers to dissemination of such traits. Teams at unique sites spanning India will study malaria parasites in human hosts, mosquito vectors, and controlled laboratory studies after adaptation to answer these questions.","6074776; ","RATHOD, PRADIPSINH K.;","RAO, MALLA R","07/01/2010","03/31/2024","Africa; Architecture; Artemisinins; Asia; Back; base; Basic Science; Cells; Cessation of life; Characteristics; Chloroquine; Choking; Clinical Markers; Clinical Research; Collection; Communities; Community Hospitals; Community Surveys; Complex; Country; Culicidae; Disease; Disease model; Dissection; Drug resistance; Drug usage; empowered; Evolution; experimental study; Failure; Family; Far East; feeding; Funding; Genomics; Government; Grant; Health; Human; human disease; Immunity; implementation science; India; Indigenous; Infection; Infrastructure; interest; international center; Laboratory Research; Laboratory Study; Latin America; Lead; Link; Malaria; malaria transmission; Medical Research; medical schools; Modernization; Molecular; molecular marker; molecular phenotype; Morbidity - disease rate; mortality; Mutagenesis; Nature; novel; parasite genome; Parasites; Pathogenesis; Pathology; Pathway interactions; Pattern; Pharmaceutical Preparations; Pharmacoepidemiology; Phenotype; Plasmodium falciparum; Plasmodium vivax; Positioning Attribute; programs; Public Health; Research; Resistance; Resources; response; Rest; Role; Running; Scientist; Severity of illness; Shapes; Site; Southeastern Asia; Training; trait; transmission process; Travel; United States National Institutes of Health; urban area; Variant; vector; vector mosquito; vector transmission; welfare; Work; ","Malaria Evolution in South Asia","089688","ZAI1","Special Emphasis Panel ","","","10","1382686","214545","1345565",""
"9674505","P20","GM","5","N","04/26/2019","04/01/2019","03/31/2020","859","P20GM103440","SCHOOLS OF MEDICINE","PAR-14-233","5P20GM103440-17","NIGMS:3473589\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","PHARMACOLOGY","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","PUBLIC HEALTH RELEVANCE (provided by applicant): This project continues the development of the Nevada IDeA Network of Biomedical Research Excellence (NV INBRE) initiated in 2005. The project will link all Nevada public universities and colleges and the state' only private liberal arts college in a network to share expertise and resources. We will increase biomedical research in the state by funding new research projects, supporting a Bioinformatics Core that provides computational power and support for genome analysis, and mentoring students enrolled in 2- and 4-year programs for education and careers in research investigating Cell Growth and Differentiation. In addition, the NV INBRE will renovate laboratory space at Nevada State College to enable students to participate in biomedical research projects.","8897571; ","BAKER, JONATHAN E.;","ARORA, KRISHAN","09/01/2001","03/31/2021","Arts; Basic Science; big biomedical data; Big Data to Knowledge; Bioinformatics; Biomedical Research; bridge program; career; cell growth; Clinical Research; college; Communication; curriculum development; Data; Development; Differentiation and Growth; Disease; Education; Enrollment; Evaluation; Experimental Designs; experimental study; Faculty; faculty mentor; Funding; genome analysis; genome wide association study; Grant; Institution; Knowledge; Laboratories; Link; Mentors; Nevada; next generation sequencing; outreach; outreach program; Pathway Analysis; Privatization; programs; Proteomics; public health relevance; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resources; Science; Services; Statistical Data Interpretation; student mentoring; Students; Technology; Training; undergraduate student; Underrepresented Students; Universities; Work; ","Nevada IDeA Network of Biomedical Research Excellence (INBRE)","103440","ZGM1","Special Emphasis Panel ","","","17","3128353","345236","3473589",""
"9674511","P20","GM","5","N","04/26/2019","04/01/2019","03/31/2020","","P20GM103440","","PAR-14-233","5P20GM103440-17","NIGMS:1570650\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","Outreach / Diversity / Pipeline Program - Project Narrative The Outreach / Diversity / Pipeline program will train a diverse workforce to be the next generation of biomedical and bioinformatics specialists in Nevada. Undergraduate students from underserved communities will experience intensive summer workshops, hands-on training, mentoring and engagement in authentic research to increase their success along the pathway to careers in biomedical and bioinformatics research.","11346171; ","ELLSWORTH, JULIE ;","","","","Address; Awareness; base; Bioinformatics; Biomedical Research; bridge program; career; cell growth; college; Communities; community college; curriculum development; Differentiation and Growth; Diverse Workforce; Economically Deprived Population; Education; education pathway; Educational Curriculum; Educational process of instructing; Educational workshop; Enrollment; experience; Future; Generations; Graduation Rates; Industry; Infrastructure; Institution; Internships; Link; Mentors; Minority; Mission; Nevada; next generation; Occupations; outreach; Pathway interactions; peer; programs; Readiness; Research; Research Personnel; Science; southern nevada; Specialist; Students; success; symposium; Teacher Professional Development; Training; undergraduate research; undergraduate student; Underrepresented Students; Underserved Population; Underserved Students; Universities; workforce needs; ","Outreach/Diversity/Pipeline Project","103440","ZGM1","Special Emphasis Panel ","7786","","17","1543426","27224","","1570650"
"9677040","R21","AR","5","N","04/26/2019","04/01/2019","03/31/2020","846","R21AR072806","SCHOOLS OF MEDICINE","PA-16-161","5R21AR072806-02","NIAMS:170361\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","WINSTON-SALEM","UNITED STATES","RADIATION-DIAGNOSTIC/ONCOLOGY","05","937727907","US","9021205","WAKE FOREST UNIVERSITY HEALTH SCIENCES","NC","271570001","PROJECT NARRATIVE Treating pelvic cancers with ionizing radiation can cause bone loss, leading to debilitating and often life- treatening fractures. This project will determine if a well-tolerated drug (4?8C) that inhibits the actions of a specific protein (IRE-1?) is an effective therapy to prevent the radiation-induced bone loss that causes pelvic, hip, and vertebral fractures.","10640190; ","WILLEY, JEFFREY S;","CHEN, FAYE H","04/01/2018","03/31/2020","Acute; Adverse effects; Aftercare; anti-cancer; Anus; Architecture; Back Pain; Binding; Biochemical; Biological Assay; bisphosphonate; bone; Bone Density; bone loss; bone preservation; bone resorbing activity; Bone Resorption; Bone structure; C57BL/6 Mouse; cancer cell; cancer diagnosis; Cancer Patient; Cancer Survivor; cancer type; Cell Nucleus; Cells; Cervical; chronic pelvic pain; Clinical; clinically relevant; Cytology; Data; Deterioration; Diagnosis; Dose; Early identification; effective therapy; Elements; Endometrial Carcinoma; Endoplasmic Reticulum; endoplasmic reticulum stress; experience; Exposure to; Female; Fracture; functional disability; Growth; Hip Fractures; Histologic; human old age (65+); imaging biomarker; Impairment; In Vitro; in vivo; in vivo Model; inhibitor/antagonist; Inositol; Intervention; Ionizing radiation; Life; Limb structure; Lysine; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant Neoplasms; microCT; Modeling; Molecular; molecular marker; Morbidity - disease rate; mortality; Neck; novel; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Osteoradionecrosis; Patients; Pelvic Cancer; Pelvis; pelvis fracture; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Postmenopause; prevent; Proteins; Publishing; Quality of life; Radiation; radiation risk; Radiation therapy; rectal; Rectal Cancer; Relative Risks; reproductive tract; response; Risedronate; Rodent; Screening for cancer; Signal Transduction; Source; Spinal Fractures; standard care; Subcutaneous Injections; Survivors; Techniques; Testing; Therapeutic; Thick; Toxic effect; tumor growth; Woman; ","Targeting IRE-1? to protect against radiation therapy-induced bone loss","072806","SBDD","Skeletal Biology Development and Disease Study Section ","","","02","115978","54383","170361",""
"9681474","R01","HL","5","N","04/27/2019","04/01/2019","03/31/2020","838","R01HL128374","","PA-13-302","5R01HL128374-05","NHLBI:365172\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","KANSAS CITY","UNITED STATES","","05","073067480","US","1529501","CHILDREN'S MERCY HOSP (KANSAS CITY, MO)","MO","641084619","PUBLIC HEALTH RELEVANCE: While sepsis in the premature infant is known to cause lung inflammation and is associated with long- term changes in the pulmonary vasculature, the underlying mechanisms remain unclear. In this application we will investigate how pulmonary endothelial immune activation during sepsis promotes lung inflammation and alters the formation of lung blood vessels. Results from these studies will enhance our understanding of sepsis-induced pro-inflammatory angiogenic signaling in the developing lung and will lay the foundation for discovery of new therapies to prevent lung disease in premature infants.","9073715; ","SAMPATH, VENKATESH ;","LIN, SARA","08/15/2015","03/31/2021","Address; angiogenesis; Angiopoietin-2; Antibodies; autocrine; axon guidance; base; Blood Vessels; Bronchopulmonary Dysplasia; Cells; Clinical Research; cytokine; Data; Development; effective therapy; Endothelial Cells; Endothelium; Enzymes; experimental study; Family; Foundations; Future; Genes; Goals; Homologous Gene; Human; ICAM1 gene; immune activation; Immune signaling; In Vitro; in vivo; Inflammation; Inflammation Mediators; Inflammatory; inhibitor/antagonist; Injury; insight; Intercellular adhesion molecule 1; jagged1 protein; KDR gene; Knowledge; Laboratories; Ligands; Link; Lipopolysaccharides; Lung; Lung diseases; Lung Inflammation; Mediating; Molecular; mouse model; Mus; NADPH Oxidase; Neonatal; neonatal sepsis; notch protein; novel; novel therapeutics; Nox enzyme; Oxidoreductase; Pathogenesis; Phenotype; Pilot Projects; Premature Infant; prevent; programs; public health relevance; Publishing; receptor; Retina; Risk Factors; Role; Scientific Advances and Accomplishments; Sepsis; Signal Pathway; Signal Transduction; small molecule; Specific qualifier value; TEK gene; Testing; Therapeutic; TIE-2 Receptor; TLR4 gene; Vascular remodeling; Work; ","Inflammatory Angiogenesis in the Lung","128374","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","","05","256827","108345","365172",""
"9683927","R01","HL","5","N","04/25/2019","04/01/2019","03/31/2020","233","R01HL142064","OVERALL MEDICAL","PAR-17-234","5R01HL142064-02","NHLBI:752085\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PORTLAND","UNITED STATES","NEUROSCIENCES","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","Project Narrative In US adults, there are large, unexplained racial disparities in hypertension. This research will (i) distinguish the relative contribution of sleep and circadian mechanisms to the increased risk for hypertension in African American (Black) adults; (ii) examine the possibility that ideal therapy for hypertension may differ by race, and (iii) lay the groundwork for optimizing therapies for hypertension dependent on mechanisms, such as targeting sleep, circadian rhythmicity, or behaviors.","6651333; ","SHEA, STEVEN A;","BROWN, MARISHKA","04/10/2018","03/31/2022","Accounting; Acute; Adult; African American; aged; American; base; Behavior; Behavioral; Behavioral Mechanisms; Biological; Black race; Blood Pressure; blood pressure reduction; blood pressure regulation; Body Temperature; caucasian American; Caucasians; circadian; circadian regulation; Circadian Rhythms; Dangerousness; Diagnostic; Diurnal Rhythm; Drops; Environment; European; Event; Exercise; Exhibits; Health; health disparity; High Prevalence; Hypertension; Hypotension; improved; innovation; Light; Morbidity - disease rate; mortality; Organ; Periodicity; Phase; Polysomnography; Prevalence; Protocols documentation; Race; racial discrimination; racial disparity; Recording of previous events; Research; response; Risk; Sleep; Sleep disturbances; sleep quality; sleep regulation; Sleep Stages; Sleep Wake Cycle; Slow-Wave Sleep; social stigma; Socioeconomic Status; Standardization; Stress; System; Testing; treatment optimization; Work; ","Sleep and Circadian Mechanisms Contributing to Disparity in Prevalence of Hypertension Between Black and White Americans","142064","ZRG1","Special Emphasis Panel ","","","02","497497","254588","752085",""
"9686382","P30","ES","2","N","04/26/2019","04/01/2019","03/31/2020","","P30ES000002","","RFA-ES-18-003","2P30ES000002-56","NIEHS:444469\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BOSTON","UNITED STATES","","07","149617367","US","3212904","HARVARD SCHOOL OF PUBLIC HEALTH","MA","021156028","","1871832; ","DOCKERY, DOUGLAS W;","","","","Area; Award; career; career development; Communities; Creativeness; Data; Discipline; Environmental Health; Facility Accesses; Feedback; Fostering; Funding; Funding Agency; Goals; Grant; Growth; Heart; innovation; Investments; Laboratories; Manuscripts; Medical; Medicine; National Institute of Environmental Health Sciences; Pathway interactions; Peer Review; Pilot Projects; programs; Publications; Research; Research Personnel; Research Project Grants; Research Support; Schools; sound; United States National Institutes of Health; Work; ","Pilot Project Program","000002","EHS","Environmental Health Sciences Review Committee ","5377","","56","278664","165805","","444469"
"9687717","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:147237\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","CORE C: PROJECT NARRATIVE The Center is committed to translation of its work to those who can take actions to protect public health and the environment, particularly key stakeholders in government agencies and end users in industry and communities. Investigators, core leaders and trainees are trained and encouraged to contribute to research translation, through an overall strategy coordinated by the Research Translation Core. The strategy has multiple levels and includes sharing research on the internet, using social media, collaborating directly with Key Stakeholders from the government agencies that are the main audience for the SRP to ensure bidirectional communication, working with UC Berkeley Office of Intellectual Property and Industry Research Alliances to make new technologies available through licensing and/or new companies and to pursue appropriate patents.","1883460; ","SMITH, MARTYN T;","","","","Address; Arsenic; base; Biomedical Engineering; Businesses; California; Charge; Chemicals; Collaborations; Communication; Communication Tools; Communities; Competence; design; Development; drinking water; Electronic Mail; Engineering; Ensure; Environment; Environment and Public Health; Environmental Engineering technology; Environmental Health; Environmental Protection; experience; Facebook; Feedback; feeding; Fostering; Future; Goals; Government; Government Agencies; Hand; Health; Health protection; health science research; Human; Image; improved; Individual; Industry; Information Centers; innovation; Intellectual Property; interest; Internet; Investigator-Initiated Research; Joints; Knowledge; Leadership; Legal patent; Licensing; Link; LinkedIn; meetings; Methods; multidisciplinary; National Institute of Environmental Health Sciences; new technology; Newsletter; Online Systems; Pathway interactions; Play; Poisons; Process; Production; programs; Public Health; Reporting; Research; Research Personnel; Role; Science; Scientific Advances and Accomplishments; Site; social media; sound; Structure; success; Superfund; superfund chemical; symposium; Technology; Technology Transfer; tool; Toxicity Tests; Training; Translating; Translational Research; Translations; Twitter; uptake; web site; webinar; Work; working group; ","Core C: Research Translation Core","004705","ZES1","Special Emphasis Panel ","5066","","31","94122","53115","","147237"
"9688231","R01","HL","5","N","04/27/2019","04/01/2019","03/31/2020","838","R01HL105278","","PA-13-302","5R01HL105278-27","NHLBI:502551\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LA JOLLA","UNITED STATES","","49","078731668","US","7210001","SALK INSTITUTE FOR BIOLOGICAL STUDIES","CA","920371002","PUBLIC HEALTH RELEVANCE: This proposal is directed at characterizing how nuclear receptors PPAR?, REV-ERB?/? and ROR?t control target genes to regulate T cell function associated with asthma development and pathogenesis. This work is anticipated to provide insights for the development of therapeutically accessible targets to ameliorate airway inflammation and asthma.","1896344; ","EVANS, RONALD M;","LIN, SARA","09/12/1990","03/31/2020","Adaptive Immune System; Address; Adrenal Cortex Hormones; Affect; Agonist; airway hyperresponsiveness; airway inflammation; Anti-inflammatory; Asthma; asthmatic; Attenuated; base; Binding; Binding Sites; Cell physiology; Cells; ChIP-seq; Chromatin; Chronic; circadian; circadian pacemaker; cytokine; Data; Development; Developmental Gene Expression Regulation; DNA Binding; Effector Cell; eosinophil; experimental study; Expression Profiling; gain of function; Gene Targeting; Genes; Genetic; genetic signature; Genetic Transcription; Genome; Genomics; Goals; Helper-Inducer T-Lymphocyte; IL17 gene; Inflammatory; insight; Interleukin-17; Interleukin-4; Knock-out; Knockout Mice; Life; Ligands; Link; loss of function; Maps; Mediating; Modeling; Molecular; Molecular Genetics; mouse model; neutrophil; novel; novel therapeutics; Nuclear Hormone Receptors; Nuclear Receptors; orphan nuclear receptor ROR-gamma; Outcome; Outcome Study; Ovalbumin; Pathogenesis; Pathway interactions; Patients; Pattern; Pharmacologic Substance; Pharmacology; Play; PPAR gamma; Production; public health relevance; Reaction; recruit; Refractory; Regulation; Resistance; response; Role; rosiglitazone; Signal Pathway; standard care; Subgroup; System; T-Lymphocyte; T-Lymphocyte Subsets; Testing; Th2 Cells; Therapeutic; therapeutic development; therapeutic target; Time; transcription factor; transcriptome; transcriptome sequencing; transcriptomics; Work; ","Spatial Regulation of Developmental Gene Expression","105278","MCE","Molecular and Cellular Endocrinology Study Section ","","","27","261860","240691","502551",""
"9692825","D43","TW","5","N","04/25/2019","04/01/2019","01/31/2020","989","D43TW009539","SCHOOLS OF MEDICINE","PAR-16-279","5D43TW009539-07","FIC:301299\","OTHER RESEARCH-RELATED","2019","FOGARTY INTERNATIONAL CENTER","","SAN FRANCISCO","UNITED STATES","INTERNAL MEDICINE/MEDICINE","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","PROJECT NARRATIVE The proposed training program will provide HIV/TB-related research training in conjunction with and support of the University of Zimbabwe's College of Health Sciences, in Harare, Zimbabwe. The training program will strengthen both the trainee pipeline and faculty of the College of Health Sciences of the University of Zimbabwe, which has been severely diminished over the past decade by economic and social problems in Zimbabwe. The goal of the proposed training program is to augment both the number and the ability of the faculty of the College of Sciences to conduct locally relevant HIV/AIDS-related research in support of the successful implementation of HIV/TB prevention and treatment programs.","10483370; 10466891 (contact); ","HAKIM, JAMES GITA; METCALFE, JOHN Z (contact);","BANSAL, GEETHA PARTHASARATHY","08/01/2013","01/31/2023","AIDS clinical trial group; AIDS/HIV problem; Biomedical Research; California; Child Health; Clinical Research; Clinical Trials; Clinical Trials Unit; Collaborations; college; Community Health; Dentistry; Development; Discipline of obstetrics; doctoral student; Ethical Issues; Faculty; Funding; Gynecology; Health; Health Sciences; HIV; HIV/TB; Human; Hygiene; IMPAACT; implementation science; Individual; innovation; Institutes; London; Medical Microbiology; Medicine; Mentorship; multidisciplinary; Pediatrics; Postdoctoral Fellow; pre-doctoral; Prevention program; prevention service; programs; Research; Research Project Grants; research study; Research Training; San Francisco; Schools; Scientist; Specialist; Students; Time; Training; Training Programs; Translational Research; treatment program; treatment services; Tropical Medicine; Tuberculosis; Universities; Zimbabwe; ","Training for Research Excellence and MeNtorship in Tuberculosis (TRENT)","009539","ZRG1","Special Emphasis Panel ","","","07","297285","4014","301299",""
"9701277","R01","MH","5","N","04/19/2019","04/24/2019","03/31/2020","242","R01MH103366","SCHOOLS OF ARTS AND SCIENCES","PAR-12-278","5R01MH103366-05","NIMH:873862\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","ATHENS","UNITED STATES","PSYCHOLOGY","10","004315578","US","676602","UNIVERSITY OF GEORGIA","GA","306021589","PUBLIC HEALTH RELEVANCE: The DSM major psychosis diagnoses (schizophrenia, schizoaffective disorder, bipolar disorder with psychosis) overlap extensively on neurobiology and genetics. Our collaborative group (called B-SNIP) developed a psychosis classification scheme (which we called Biotypes) using biological measures that are superior to DSM diagnoses for capturing neurobiological similarities and differences. In this project, we will broaden and extend this work to refine the neurobiological Biotype definitions, characterize unique molecular and genetic features of Biotypes, and test various classifications using multivariate approaches, which will be an important step toward personalized medicine for psychiatry.","1861110 (contact); 1955069; 11030195; ","CLEMENTZ, BRETT A (contact); GIBBONS, ROBERT D; MILLER, BRIAN JAMES;","RUMSEY, JUDITH M","07/01/2015","03/31/2020","Address; Area; base; Biologic Characteristic; Biological; Biological Markers; biomarker panel; Bipolar Disorder; Blood; Brain; Brain imaging; case control; Categories; Characteristics; Classification; Classification Scheme; Clinical; clinical heterogeneity; clinical phenotype; Cognitive; Complex; Data; Databases; Diagnosis; Diagnostic; Diagnostic Specificity; Dimensions; Disease; DSM-IV; Electrophysiology (science); Etiology; Genetic; genetic analysis; Goals; healthy volunteer; Heritability; Image; Institutes; Laboratories; Measures; Medicine; Molecular Genetics; Multivariate Analysis; Names; neurobiological mechanism; Neurobiology; Neurologic Symptoms; novel; oculomotor; Outcome; Participant; personalized medicine; phenomenological models; Phenotype; phenotypic biomarker; Physiological; Positioning Attribute; proband; Procedures; Psychiatric Diagnosis; Psychiatry; Psychophysiology; psychosocial; Psychotic Disorders; public health relevance; recruit; relating to nervous system; Sampling; Schizoaffective Disorders; Schizophrenia; Site; social; Specific qualifier value; Structure; Subgroup; Symptoms; System; Taxonomy; Testing; volunteer; Work; ","5/5 BIPOLAR-SCHIZOPHRENIA NETWORK FOR INTERMEDIATE PHENOTYPES (B-SNIP) - Resubmission - 1","103366","ZMH1","Special Emphasis Panel ","","","05","624524","249338","873862",""
"9701962","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:171503\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","","1936207; ","GOLDFINE, ALLISON B;","","","","Adult; Algorithms; Back; bariatric surgery; Basic Science; bench to bedside; biobank; Biological Models; Biology; Biopsy; Brown Fat; Caring; Cell Line; Childhood; Clinical; clinical care; clinical investigation; Clinical Investigator; Clinical Research; Clinical Trials; Closure by clamp; cohort; Cohort Studies; Collaborations; comparative effectiveness; Complex; Complications of Diabetes Mellitus; Consultations; Core Facility; Custom; Data Analyses; data management; design; Development; Diabetes Mellitus; Discipline of Nursing; Endocrine; Energy Metabolism; epidemiology study; Equipment; Evaluation; Exercise; Exercise stress test; exercise training; experimental study; Eye; Faculty; faculty research; Fatty acid glycerol esters; Feces; first-in-human; fitness; Funding; Gestational Diabetes; Glomerular Filtration Rate; Glucose; glucose monitor; Goals; Gold; Growth; Growth and Development function; Home environment; Human; Hyperglycemia; Hypoglycemia; improved; Individual; Infrastructure; Infusion procedures; Institution; Insulin; insulin secretion; Insulin-Dependent Diabetes Mellitus; Intravenous; Investigation; Kidney; knowledge base; Laboratories; man; Measures; Mentors; Metabolic; Metabolic Diseases; Metabolism; Methodology; Methods; Modeling; multidisciplinary; Muscle; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; novel; nutrition; Observational Study; Oral; patient oriented; Patients; pediatric patients; Pharmacologic Substance; Pharmacology; Phase; Phenotype; Physiological; Physiology; Plasma; Preparation; Prevention; Principal Investigator; Process; programs; Protocols documentation; Registries; Research; Research Design; research facility; Research Methodology; Research Personnel; Research Project Grants; Research Support; Sampling; Scientist; Seminal; Serum; Services; Skin; Specimen; Techniques; Testing; Therapeutic; Tissues; Tracer; Training; Translational Research; translational research program; Translations; treatment optimization; Urine; volunteer; ","Clinical Translational Research Core","036836","ZDK1","Special Emphasis Panel ","7093","","33","101631","69872","","171503"
"9701968","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:76631\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","","1911538; ","MUSEN, GAIL F;","","","","Area; Awareness; Basic Science; Boston; Clinical; clinical care; Clinical Research; Clinical Sciences; Communities; Data; Diabetes Mellitus; Economics; Educational Status; Ethics; Faculty; Fostering; Funding; Goals; graduate student; Growth; health care delivery; Individual; Insulin-Dependent Diabetes Mellitus; interest; International; Journals; Knowledge; lecturer; lectures; Marble; Medical; Medical Students; member; Metabolism; Names; new technology; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Participant; Physicians; posters; professor; programs; Research; Research Personnel; Scientist; Series; Services; Students; summer program; summer research; symposium; undergraduate student; Visit; ","Enrichment Program","036836","ZDK1","Special Emphasis Panel ","7098","","33","45411","31220","","76631"
"9702549","P40","OD","2","N","04/22/2019","04/01/2019","03/31/2020","","P40OD010952","","PAR-17-006","2P40OD010952-24","OD:56225\","RESEARCH CENTERS","2019","OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH","","KEY BISCAYNE","UNITED STATES","","27","152764007","US","10011242","UNIVERSITY OF MIAMI ROSENTEIL SCHOOL","FL","331491031","The California sea hare, Aplysia californica, is a large marine snail that has proven to be an outstanding model for studies of how the nervous system functions, particularly in memory and learning, as well as in understanding human diseases that affect these functions. The National Resource for Aplysia raises and ships 10,000 to 15,000 of these animals per year to research laboratories. This proposal would continue the production of these animals and expand their usefulness for studies of aging, lifespan extension, and mechanisms of resistance to the type of nervous system injuries encountered in stroke.","1865602; ","SCHMALE, MICHAEL C;","","","","Address; Adult; Affect; aged; Aging; Animals; Aplysia; Aplysia species; Applied Research; Behavior; Biological Models; Biomedical Research; Brain Hypoxia-Ischemia; California; Caloric Restriction; cell injury; Characteristics; cohort; Complex; coping mechanism; cost; Data; Diet; DNA; Education; egg; Elderly; experimental study; Expression Profiling; Ganglia; Gene Expression; Genes; Genetic Transcription; Genome; Glycolysis; Goals; Grant; Harvest; human disease; human subject; Hypoxia; improved; Injury; insight; Laboratory Research; Learning; Life; Life Cycle Stages; Longevity; Malnutrition; Maps; Marines; Memory; Metabolic; Mission; Mitochondria; Modeling; Molecular; Nervous System Physiology; Nervous system structure; Nervous System Trauma; Neurons; neurophysiology; neurotransmission; novel; Parents; Pathway interactions; Pattern; Phase; Phenotype; Physiological; Physiology; Play; Production; programs; Protocols documentation; receptor; Reflex action; Reperfusion Injury; reproductive; Research; Research Personnel; Research Project Grants; resilience; Resistance; resistance mechanism; Resources; RNA; Role; Sales; Sampling; senescence; Ships; Siblings; Snails; Stroke; stroke model; Study models; Syndrome; System; Tissues; transcriptome; transcriptome sequencing; transcriptomics; Universities; ","Applied Research","010952","ZRG1","Special Emphasis Panel ","7577","","24","36274","19951","","56225"
"9780664","I01","VA","1","N","04/26/2019","04/01/2019","03/31/2020","999","I01BX004542","","RFA-BX-18-003","1I01BX004542-01A1","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","LEXINGTON","UNITED STATES","","06","018766373","US","481036","VA MEDICAL CENTER - LEXINGTON, KY","KY","405022235","Human posttraumatic epilepsy (PTE) is defined as repeated, unprovoked seizures beginning more than one week, but up to years, after a traumatic brain injury (TBI). During the seizure-free interval between TBI and PTE, the brain undergoes changes leading to a state of chronically increased seizure susceptibility. The molecular mechanisms and network changes underlying this posttraumatic epileptogenesis (PTEgenesis) are largely unknown and there are no therapeutic strategies to prevent it. Our approach using microelectrode arrays, immunohistochemistry, slice electrophysiology, quantitative protein biochemistry, and optogenetics to analyze this latent period should allow us to correlate network, neuronal, and presynaptic release changes to molecular, anatomical, electrophysiological, and behavioral outcomes associated with PTEgenesis. In addition, these studies will test a potentially novel therapy to retard/halt PTEgenesis. Thus, this research is directly relevant to the care of a large proportion of service men and women, veterans, and the general population.","9405862; ","SLEVIN, JOHN T.;","","04/01/2019","03/31/2023","Acute; Anatomy; Animal Model; Animals; Antiepileptogenic; Behavioral; behavioral outcome; Biochemical; Brain; Caring; Cells; Chronic; Chronic Disease; Clinical Trials; controlled cortical impact; critical period; Custom; Data; dentate gyrus; Development; economic cost; Electrochemistry; Electrophysiology (science); Epilepsy; Epileptogenesis; Equilibrium; Excision; extracellular; General Population; Glutamates; Goals; Halorhodopsins; high risk; Hippocampus (Brain); Human; Immunohistochemistry; Individual; Injury; instrumentation; Life; Measures; Medical; men; Methods; Microelectrodes; Modeling; Molecular; Neurons; Neurosurgical Procedures; neurotransmitter release; novel; novel therapeutics; optogenetics; Oxygen; Patients; Phenotype; Physiological; Population; Post-Traumatic Epilepsy; Predisposition; presynaptic; prevent; Process; promoter; Protein Biochemistry; Rattus; real time monitoring; Recurrence; relating to nervous system; Research; Seizures; Services; Slice; standard of care; synaptogenesis; Techniques; Testing; Therapeutic; Time; tool; Transfection; Translations; Traumatic Brain Injury; United States; vesicular release; Veterans; Viral; Western Blotting; Woman; ","Optogenetics: A tool to probe mechanism and an agent to block TBI-induced epileptogenesis.","004542","ZRD1","Special Emphasis Panel ","","A1","01","","","",""
"9797676","R44","MH","4","N","04/22/2019","04/22/2019","03/31/2020","242","R44MH116765","","PA-17-302","4R44MH116765-02","NIMH:615300\","SBIR-STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","ANNAPOLIS","UNITED STATES","","03","140735569","US","10045025","TERRAPIN PHARMACY","MD","214014113","","14987369; ","FELDMAN, JOEL F;","HAIM, ADAM","07/19/2018","03/31/2021","","ASSESSMENT OF MEDHERENT MEDICATION MANAGEMENT DEVICE AND ADHERENCE PLATFORM","116765","ZRG1","Special Emphasis Panel ","","","02","","","615300",""
"9826044","R43","CA","3","N","04/24/2019","03/01/2019","05/31/2020","395","R43CA217385","","PA-19-029","3R43CA217385-02S1","NCI:55000\","SBIR-STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","Salt Lake City","UNITED STATES","","02","080116475","US","10042655","KUDA THERAPEUTICS, INC.","UT","841032206","Project Narrative Kidney cancer is among the most drug resistant of solid tumors, and is uniquely dependent upon HIF-2? for its continued growth and progression. We have identified a molecule that specifically blocks HIF-2? production and slows tumor growth in mice. Our studies will improve this molecule in order to facilitate its commercial development as a new medicine for the treatment of kidney cancer.","15162858; ","LIU, XIAOHUI ;","KURTZ, ANDREW J","06/01/2018","05/31/2020","5' Untranslated Regions; Affect; base; bHLH-PAS factor HLF; Binding; biomarker validation; cell growth; cell type; Characteristics; chemotherapy; Clear Cell; Development; Dose; Drug resistance; Elements; Ferritin; Genetic Transcription; Goals; Growth; Hepatotoxicity; high throughput screening; Hypoxia Inducible Factor; improved; In Vitro; in vivo; inhibitor/antagonist; Iron; Iron Regulatory Protein 1; Lead; lead series; Medicine; Messenger RNA; Metabolic; Mus; nephrotoxicity; novel; novel strategies; Patients; pharmacodynamic biomarker; Pharmacodynamics; Phase; Plasma; Play; Production; Proteins; Radiation; Renal carcinoma; Renal Cell Carcinoma; Resistance; Role; Series; Solid Neoplasm; Structure-Activity Relationship; Therapeutic; Tissues; Toxic effect; Translations; tumor; tumor growth; Tumor Suppressor Proteins; Xenograft procedure; ","Development of a novel class of selective HIF-2A inhibitors for kidney cancer","217385","ZRG1","Special Emphasis Panel ","","S1","02","","","55000",""
"9866136","R01","DK","7","N","04/25/2019","07/03/2018","06/30/2019","847","R01DK107566","SCHOOLS OF PUBLIC HEALTH","PAR-12-265","7R01DK107566-04","NIDDK:552375\","Non-SBIR/STTR RPGs","2018","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NEW ORLEANS","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","01","053785812","US","8424601","TULANE UNIVERSITY OF LOUISIANA","LA","701185665","Chronic kidney disease (CKD) may alter the homeostatic relationship between human hosts and their intestinal tract microbial inhabitants (i.e., the gut microbiota) due to the enhanced delivery of urea to the gut microbiota, alterations in diet, and the decrease in urinary excretion of small molecules produced by the gut microbiota. As a result, both the composition of the gut microbiota and its metabolite by-products may be altered in patients with CKD. Our overall study goal of investigating the role of the gut microbiota and gut-derived metabolites in altering the risk of major clinical outcomes associated with CKD will be accomplished using a longitudinal prospective cohort within the Chronic Renal Insufficiency Cohort (CRIC) Study, and a small additional population of CKD patients.","9514186 (contact); 1877201; ","ANDERSON, AMANDA HYRE (contact); WU, GARY D.;","NARVA, ANDREW","09/20/2016","06/30/2021","","The Gut Microbiome and The Metabolome in Chronic Kidney Disease","107566","ZDK1","Special Emphasis Panel ","","","04","440612","111763","552375",""
"9875961","UG1","DA","3","N","04/22/2019","02/21/2019","05/31/2019","279","UG1DA013732","SCHOOLS OF MEDICINE","PA-18-591","3UG1DA013732-19S4","NIDA:160705\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","CINCINNATI","UNITED STATES","PSYCHIATRY","01","041064767","US","1523902","UNIVERSITY OF CINCINNATI","OH","452210001","Project Narrative: Since its establishment in 2000, the Ohio Valley Node (OVN) has been one of the most productive of NIDA's Clinical Trials Network (CTN) nodes, both in leading and participating in multi-site trials. The wealth of experience and expertise gained over the past 14 years has been used to cultivate collaborations with other research networks to form the Ohio Valley Node-Network (OVNN). Our primary goal is to conduct the research needed to inform clinical practice guidelines for effective substance use disorder prevention and treatment in general medical care settings, which are largely lacking but increasingly needed, with a specific focus on research to address the opioid abuse epidemic.","1908004; ","WINHUSEN, THERESA M;","DOBBINS, RONALD","09/30/2000","05/30/2020","Accident and Emergency department; addiction; Address; Adopted; Adoption; Advocate; Alcohol or Other Drugs use; Appalachian Region; Award; base; Buprenorphine; Caring; Clinical; clinical practice; Clinical Practice Guideline; clinical research site; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Conduct Clinical Trials; Cultural Diversity; Data; disorder prevention; driving force; Education; Elderly; Electronic Health Record; Emergency Medicine; Epidemic; experience; Geography; Goals; Health Personnel; HIV/HCV; implementation research; Indiana; Individual; innovation; Institution; Intervention; Intervention Trial; Leadership; Link; Medical; member; Mississippi; Multi-Institutional Clinical Trial; multi-site trial; National Institute of Drug Abuse; Native Americans; novel; Ohio; opioid abuse; opioid misuse; opioid overdose; Overdose; Patients; pediatric emergency; peer; Pharmacy facility; Policies; Practice based research; practice setting; practice-based research network; Pragmatic clinical trial; prevent; Primary Health Care; Productivity; Property; Provider; Public Health; Recording of previous events; Research; Research Personnel; screening and brief intervention; screening, brief intervention, referral, and treatment; Site; statistics; Substance Use Disorder; Testing; transmission process; U-Series Cooperative Agreements; Vision; Wisconsin; Work; ","Ohio Valley Node-Network (OVNN) of the NIDA Clinical Trials Network","013732","","","","S4","19","133415","27290","160705",""
"9888893","R43","DK","3","N","04/24/2019","08/01/2018","07/31/2019","847","R43DK119089","","PA-17-302","3R43DK119089-01S1","NIDDK:55000\","SBIR-STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","SAN DIEGO","UNITED STATES","","52","859217234","US","2825901","ACCENTS ON HEALTH, INC.","CA","921231767","Narrative The overall aim of the project is to improve quality of life and reduce diet-related complications for individuals living with type 2 diabetes mellitus. This study examines the feasibility of interactive mobile health technology that incorporates personalized guidance designed to motivate and empower those with diabetes to engage in self-care practices related to making healthier choices at restaurants.","11576891; ","PATEL, ANJALI ;","ARREAZA-RUBIN, GUILLERMO","08/01/2018","07/31/2019","American; base; Behavior; behavior test; Behavioral; Calories; Centers for Disease Control and Prevention (U.S.); Collaborations; Cross-Sectional Studies; Data; Data Analyses; Data Collection; design; diabetes educator; diabetes management; Diabetes Mellitus; Diabetic Diet; Diet; digital; Diné Nation; Doctor of Philosophy; Eating; Evaluation; Expenditure; experience; fast food; Fatty acid glycerol esters; Feasibility Studies; Feedback; Focus Groups; Food; food consumption; Goals; Guidelines; Health; Health Technology; Healthy Eating; Home environment; improved; Individual; informant; Institutes; Instruction; instrument; Intake; Internet; Intervention; Interview; mHealth; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; nutrition; Obesity; Outcome; Participant; Patient Recruitments; Pattern; Phase; phase 2 study; Population; Pre-Post Tests; Prevalence; Prevention Research; Procedures; Process; prototype; Qualifying; Quality of life; Recommendation; recruit; Reducing diet; Reporting; Research; Restaurants; Risk Factors; saturated fat; Self Care; Self Management; Sodium; sugar; Surveys; Technology; Testing; theories; tool; trend; ","Dining with Diabetes: Personalized Technology for Self-Management","119089","ZRG1","Special Emphasis Panel ","","S1","01","","","55000",""
"9901071","R43","CA","3","N","04/22/2019","09/06/2018","08/31/2019","395","R43CA228707","","PA-17-302","3R43CA228707-01A1S1","NCI:55000\","SBIR-STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","BUFFALO","UNITED STATES","","26","079908882","US","10040035","POP BIOTECHNOLOGIES, LLC","NY","142141029","PROJECT NARRATIVE The ability to selectively deliver drugs with precise spatial and temporal control could lead to entirely new approaches to treatments of solid tumors. We have demonstrated anti-tumor proof of principle for a new class of doxorubicin-loaded long-circulating liposomes that rapidly release drug in response to near infrared light, a safe and clinically proven stimulus. A scalable manufacturing strategy for these liposomes will be developed and preliminary pharmacokinetics, efficacy, and toxicity in rats will be assessed.","14634350 (contact); 11825097; ","CARTER, KEVIN A (contact); KUTSCHER, HILLIARD ;","KURTZ, ANDREW J","09/06/2018","08/31/2019","Adverse effects; Animal Model; Animals; Applications Grants; base; Biological; biomaterial compatibility; Biotechnology; Blood flow; Breast Cancer Model; Breast Cancer Patient; Buffaloes; Caliber; cancer therapy; Canis familiaris; Caring; Chest wall structure; Cholesterol; Clinical; Clinical Data; Clinical Treatment; Clinical Trials; clinically relevant; Communication; Cutaneous; Data; Deposition; Development; Development Plans; Dose; dosimetry; Doxorubicin; Doxorubicin Hydrochloride Liposome; Drug Kinetics; effectiveness measure; Environment; Evaluation; Exhibits; experience; Exposure to; FDA approved; Formulation; Future; Generations; Human; improved; in vivo; insight; intravenous injection; Investigational Drugs; Investigational New Drug Application; Ionizing radiation; irradiation; Lasers; Lead; Lesion; Light; Lipids; Liposomal Doxorubicin; Liposomes; malignant breast neoplasm; Mass Spectrum Analysis; Measures; Metastatic breast cancer; mid-career faculty; Modality; Modeling; mouse model; nanoparticle; nanovesicle; Nature; novel; novel strategies; Operative Surgical Procedures; orthotopic breast cancer; Outcome; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Phospholipids; Photosensitivity; Phototherapy; Porphyrins; pre-clinical; Pre-Clinical Model; pressure; Production; Property; Protocols documentation; Publishing; PUVA Photochemotherapy; Quality of life; Radiation therapy; Rattus; Records; Recurrence; response; Risk; safety study; scale up; Scientist; Serum; Site; Small Business Technology Transfer Research; Solid Neoplasm; Standardization; Stimulus; Survival Rate; System; Techniques; Technology; Therapeutic; therapeutic effectiveness; Toxic effect; translation to humans; tumor; tumor ablation; tumor eradication; Tumor Volume; Universities; Vascular Permeabilities; Woman; Work; ","Scalable Formulation and Production of Photosensitive Nanoparticles for Cancer Therapy","228707","ZRG1","Special Emphasis Panel ","","A1S1","01","","","55000",""
"9901983","UG1","DA","3","N","04/22/2019","02/28/2019","05/31/2019","279","UG1DA013035","SCHOOLS OF MEDICINE","RFA-DA-15-008","3UG1DA013035-17S8","NIDA:35922\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","NEW YORK","UNITED STATES","PSYCHIATRY","12","121911077","US","5998304","NEW YORK UNIVERSITY SCHOOL OF MEDICINE","NY","10016","PUBLIC HEALTH RELEVANCE:  Addictions, including nicotine, drugs and alcohol, represent a major public health problem. Research is needed to translate new basic and therapeutic advances into effective and accessible treatment in our communities. The NIDA Clinical Trials Network and the Greater New York Node seek to fill this gap by engaging researchers, healthcare providers from primary care to specialty care, and policy-makers in research to improve addictions treatment nationally using science as the vehicle.","8192463; 2414926 (contact); ","NUNES, EDWARD V.; ROTROSEN, JOHN P (contact);","DOBBINS, RONALD","01/10/2001","05/31/2020","Academia; addiction; Address; Adolescent; Adopted; Adoption; Alcoholism; Alcohols; Area; base; Behavior Therapy; behavioral health; Budgets; care coordination; care outcomes; care providers; Caribbean region; Caring; Charge; Cities; Clinical; Clinical Management; Clinical Trials; Clinical Trials Network; Collaborations; college; Communities; comparative effectiveness; cost; Criminal Justice; Data; Development; Disease; disorder prevention; Early Intervention; eHealth; Electronic Health Record; epidemiology study; experience; Fostering; Freedom; Funding; Future; Gender Issues; Genetic; Genetic Research; Goals; Health; health care service organization; health care settings; health information technology; health management; Health Personnel; Health Services; Health Services Research; Health system; Healthcare Systems; Hepatitis C virus; HIV; HIV/HCV; Hospitals; improved; improved outcome; Individual; Infection; Infrastructure; innovation; Institution; Leadership; Learning; Long Island; Mainstreaming; Medical; Medical Informatics; medical schools; medical specialties; Medical Technology; Medicine; Mental disorders; Mental Health; Mentorship; Methodology; Methods; metropolitan; mHealth; National Institute of Drug Abuse; neuroimaging; Neurosciences; Neurosciences Research; New York; next generation; Nicotine; Patients; Pediatrics; performance site; Pharmaceutical Preparations; Pharmacotherapy; Phase; Policy Maker; Population; pragmatic trial; Prevention; Primary Health Care; Private Hospitals; programs; Provider; Public Health; public health relevance; Public Hospitals; Registries; Research; Research Personnel; Research Training; Resources; Risk Reduction; Science; screening; Services; Smoking; Substance abuse problem; Substance Use Disorder; System; Technology Transfer; Testing; Therapeutic; Training; Translating; treatment program; treatment services; treatment strategy; Universities; vaccine development; Vision; ","NIDA Clinical Trials Network: Greater New York Node","013035","ZDA1","Special Emphasis Panel ","","S8","17","32848","3074","35922",""
"9917067","K01","MH","7","N","04/22/2019","10/01/2018","03/31/2020","242","K01MH107256","SCHOOLS OF NURSING","PA-14-044","7K01MH107256-05","NIMH:82293\","OTHER RESEARCH-RELATED","2018","NATIONAL INSTITUTE OF MENTAL HEALTH","","NASHVILLE","UNITED STATES","NONE","05","965717143","US","8721001","VANDERBILT UNIVERSITY","TN","372407749","PUBLIC HEALTH RELEVANCE: HIV-positive women in South Africa are at high risk of dropping out of HIV care soon after delivery, endangering the life of the mother and infant. The impact of population mobility around the time of delivery on retention in HIV care is unknown. This mentored K01 award will support training and research to explore the impact of population mobility on retention in postpartum HIV care and gather critical information for the development of future interventions to improve retention in HIV care.","12190399; ","CLOUSE, KATE ;","GORDON, CHRISTOPHER M","04/01/2015","03/31/2020","","Population mobility and retention in HIV care among postpartum women in South Africa","107256","BSCH","Behavioral and Social Consequences of HIV/AIDS Study Section ","","","05","76197","6096","82293",""
"9921523","Y01","AI","","N","","","","","Y01AI170230","","","AAI17023001-01-0-1","NIAID:180000\","INTERAGENCY AGREEMENTS","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","","","","","","","","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","","","15965340; ","INDIRA, HEWLETT ;","","","","Agreement; Antigens; base; Biological Assay; Blood donor; Complex; Diagnostic; Dideoxy Chain Termination DNA Sequencing; Generations; genome sequencing; Genotype; HIV; HIV Core Protein p24; Methods; nanoparticle; National Institute of Allergy and Infectious Disease; next generation; Patients; Performance; Pharmaceutical Preparations; Plasma; Public Health; repository; Research; Sampling; Testing; transcriptome sequencing; vaccine trial; Variant; Viral; Viral Load result; Virus; whole genome; Work; ","Characterize Merging HIV Strains from Blood Donors and Patients","","","","","","","","","180000",""
"9456704","R01","DA","5","N","04/23/2019","04/01/2019","03/31/2020","279","R01DA037974","SCHOOLS OF MEDICINE","PA-14-025","5R01DA037974-04","NIDA:710825\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","NEW HAVEN","UNITED STATES","PSYCHIATRY","03","043207562","US","9420201","YALE UNIVERSITY","CT","065208327","PUBLIC HEALTH RELEVANCE: Methamphetamine addiction is a hugely destructive public health problem that is surging worldwide, including in many parts of the US and Asia, where Thailand is one of the most profoundly affected countries worldwide. Although a significant portion of the risk for methamphetamine addiction is genetic, no genes for the disorder have been identified to date, in large part because of insufficient study of large enough numbers of people who are affected (a major advantage of conducting such work in Thailand) and the failure to use modern genome wide approaches. The identification of genes underlying the risk for methamphetamine addiction will shed light on the underlying causes of the disorder, and in turn, lead to improvements in our understanding and treatment, and ultimately prevention, of this devastating problem.","1864273; 7136013 (contact); ","GELERNTER, JOEL ; MALISON, ROBERT T (contact);","POLLOCK, JONATHAN D","06/15/2015","03/31/2021","Affect; African American; Alcoholism; Amphetamines; Asia; Asians; base; bead chip; Chinese People; Clinical; Cocaine; cohort; Collaborations; cost; Country; Data; design; Diagnosis; Diagnostic; discount; discounting; Disease; DNA; Drug abuse; Drug Addiction; DSM-IV; endophenotype; Epidemic; European; exome sequencing; Faculty; Failure; Funding; Future; Genes; Genetic; genetic analysis; genetic risk factor; Genetic study; genetic variant; genome analysis; genome wide association study; genome-wide; Heritability; Heterogeneity; Hospitals; Human Genetics; Iceland; improved; Impulsivity; Individual; Infrastructure; Institutes; instrument; International; Lead; Light; Logistics; Medicine; meetings; Methamphetamine; Methamphetamine dependence; methamphetamine exposure; Methods; Modernization; Neurobiology; Pathway interactions; Phenotype; Population; Prevalence; Prevention; Principal Investigator; Psychostimulant dependence; Public Health; public health relevance; rare variant; Reaction Time; recruit; Research; response; Risk; risk sharing; risk variant; sample collection; Sampling; Severities; Signal Transduction; Site; SNP array; Structure; Testing; Thailand; Universities; Variant; Work; ","Identifying Methamphetamine Risk Variants by Extreme Phenotype Exome Sequencing","037974","BGES","Behavioral Genetics and Epidemiology Study Section ","","","04","517037","193788","710825",""
"9627002","U24","CA","2","N","04/22/2019","04/22/2019","02/29/2020","395","U24CA180803","","RFA-CA-17-060","2U24CA180803-06","NCI:8087572\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","RESTON","UNITED STATES","","11","062485800","US","9510402","AMERICAN COLLEGE OF RADIOLOGY","VA","201914326","Today?s cancer trials frequently require the use of imaging and/or radiation therapy to achieve the most effective treatment. Rigorous QA of these methodologies secures consistency across participating sites by managing potential variability which would otherwise obscure true therapeutic outcomes.","7819328 (contact); 7035764; ","FOLLOWILL, DAVID S (contact); KNOPP, MICHAEL V;","MOONEY, MARGARET M","05/26/2014","02/28/2025","Aftercare; American College of Radiology; clinical imaging; Clinical Management; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Design; Communication; Communication Programs; Consultations; Credentialing; Data; data acquisition; Data Collection; data management; Data Set; Development; Disease; effective therapy; Ensure; Funding; Grant; Image; Information Systems; Information Technology; Infrastructure; Leadership; Location; Malignant Neoplasms; member; Methodology; Modality; Modernization; National Cancer Institute; National Clinical Trials Network; Ohio; Oncology Group; operation; organizational structure; Outcome; Patients; Philadelphia; Principal Investigator; Procedures; Process; programs; prospective; protocol development; quality assurance; Radiation Oncology; Radiation therapy; Recommendation; Rhode Island; Secure; Services; Site; Subgroup; Technical Expertise; Technology; therapy outcome; Time; tool; trial design; Uncertainty; Universities; Vision; Washington; Work; ","Imaging and Radiation Oncology Core (IROC) Group","180803","ZCA1","Special Emphasis Panel ","","","06","6979916","1161025","8087572",""
"9638293","U10","CA","2","N","04/26/2019","03/01/2019","02/29/2020","","U10CA180888","","RFA-CA-17-056","2U10CA180888-06","NCI:2888328\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","6765159; ","BLANKE, CHARLES D.;","","","","cancer clinical trial; Communication; Ensure; improved; member; Monitor; named group; operation; Patient advocacy; Patients; rare cancer; Recruitment Activity; Research; Resources; Site; Southwest Oncology Group; Work; ","SWOG Network Group Operations Center of the NCTN","180888","ZCA1","Special Emphasis Panel ","7182","","06","3589250","399870","","2888328"
"9661305","R01","HD","1","N","04/22/2019","04/23/2019","03/31/2020","865","R01HD092474","SCH OF HOME ECON/HUMAN ECOLOGY","PAR-18-039","1R01HD092474-01A1","NICHD:621133\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","FORT COLLINS","UNITED STATES","OTHER HEALTH PROFESSIONS","04","785979618","US","1725201","COLORADO STATE UNIVERSITY","CO","805232002","Project Narrative The transition from adolescence to adulthood and employment is a significant challenge for individuals with intellectual disabilities; obtaining and keeping a job are particularly difficult for this population. A critical limitation exists in our ability to appropriately and accurately assess and predict the best fit between individuals' skills and interests and job demands and activities, and this application seeks to quantify the reliability, validity, responsiveness, and clinical utility of the Vocational Fit Assessment with PwID in diverse special education and vocational rehabilitation settings. The VFA provides accurate, person-centered measures of work-related interests and adaptive behavior that both inform employment services and predicts problems?preventing job loss and keeping PwID employed.","9646163; 12390973 (contact); 11424593; ","KRAMER, JESSICA MARVELLE; PERSCH, ANDREW C. (contact); PFEIFFER, BETH ;","KAU, ALICE S","04/23/2019","03/31/2024","Adaptive Behaviors; Adolescence; Adolescent; Adult; Age; Algorithms; American; Area; base; Clinical; Clinical assessments; Communities; Custom; Data; Data Analyses; Data Collection; design; disability; Employment; Employment Status; Evaluation; experience; Face; Factor Analysis; Focus Groups; Goals; Growth; Health; high school; improved; Individual; Intellectual functioning disability; interest; International; Intervention; Interview; Measures; Methods; Modeling; Modification; Monitor; Occupations; Outcome; Outcome Measure; Parents; Participant; person centered; Population; prevent; Process; programs; Provider; Proxy; Psychometrics; Quality of life; Reporter; Reporting; Research; Research Methodology; response; secondary analysis; Self Efficacy; Services; shared decision making; skills; social; Special Education; Statistical Data Interpretation; stem; Surveys; System; Testing; Time; Training; Unemployment; Validity and Reliability; Vocational rehabilitation; Work; Youth; ","Vocational Fit Assessment and Employment Status in People with Intellectual Disabilities","092474","ZRG1","Special Emphasis Panel ","","A1","01","496101","125032","621133",""
"9665264","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","307","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:1\NHGRI:2218942\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","PUBLIC HEALTH RELEVANCE     Narrative Our Center is designed to fill an important gap in disparities science by developing robust methods to enable examination of multilevel determinants that drive disparity broadly and not for a specific disease phenotype. This approach is critical because determinants of disparity are likely similar/shared and we can use findings to devise interventions that tackle determinants not simply disease risk.","3075104; 7773103; 1857623; 7182203 (contact); ","COX, NANCY J; LIMA, MARIA F; WEISS, ROY E; WILKINS, CONSUELO HOPKINS (contact);","RAJAPAKSE, NISHADI","05/19/2016","03/31/2021","Academic Medical Centers; Address; Adult; Adverse event; African American; Area; Asthma; Behavioral; biobank; Biological; cardiometabolism; Cardiovascular Diseases; Childhood; Clinical; Collaborations; Communities; Data; design; Diabetes Mellitus; Disease; disease phenotype; disorder risk; DNA; Doctor of Philosophy; Electronic Health Record; Employment; Environmental Risk Factor; Ethics; ethnic minority population; Ethnic Origin; Event; experience; Face; Faculty; fetal; Fostering; Foundations; Funding; General Population; Genetic; genomic data; genomic variation; Genomics; gestational weight gain; Growth; Health; health disparity; Health Professional; Hispanics; Human; Hypertension; Income; Individual; individual variation; Infrastructure; Institutes; Institution; Intention; International; Intervention; Investigational Therapies; Latino; Lead; Life; Link; Lipids; Malignant Neoplasms; Medical center; medical schools; Medicine; member; Metabolic; Methods; Minority; Mississippi; Modeling; novel; Obesity; obesity in children; Pathway interactions; personalized medicine; Persons; Pharmaceutical Preparations; Pharmacotherapy; phenotypic data; Population; population health; pre-pregnancy obesity; Precision Health; precision medicine; predictive modeling; prevent; Prevention strategy; public health relevance; Race; racial minority; Research; Research Training; resilience; Resources; response; Risk; Safety; Sampling; Schools; Science; screening; Secure; social; Societies; Specificity; stressor; Testing; therapy outcome; trait; Transcend; treatment strategy; United States National Institutes of Health; Universities; Vulnerable Populations; ","Center of Excellence in Precision Medicine and Population Health","010722","ZMD1","Special Emphasis Panel ","","","04","2142981","514630","2218943",""
"9669082","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:143124\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","8765378; ","WANG, JING ;","","","","Biomedical Research; Cell Line; Cells; Centers of Research Excellence; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Core Facility; cost; CRISPR/Cas technology; Data; design; Development; Disease Outcome; Ensure; environmental intervention; Equipment; experience; Explosion; Generations; Genes; Genetic; genome editing; Genotype; Goals; Home environment; Image; imaging capabilities; Imaging Device; imaging facilities; Indirect Calorimetry; interest; Intervention; Knock-in; Knock-out; Link; loss of function; Maintenance; meetings; Metabolic; Modeling; Molecular; Molecular Target; Monitor; mouse model; Mus; Nebraska; new technology; new therapeutic target; novel; Patient-Focused Outcomes; Pharmacology; Physiological; Plasmids; preclinical study; Process; Production; Proteins; Research; Research Personnel; Resources; Services; System; Technology; Therapeutic; Time; Training; tumor; tumor xenograft; Validation; Xenograft Model; ","Target Validation Core","121316","ZGM1","Special Emphasis Panel ","8786","","02","93852","49272","","143124"
"9672442","P30","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P30ES009089","","RFA-ES-17-003","5P30ES009089-21","NIEHS:409329\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","NEW YORK","UNITED STATES","","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","","8651962; ","BACCARELLI, ANDREA ;","","","","Advisory Committees; Applications Grants; base; Biometry; Budgets; career; career development; Collaborations; college; Communication; Communities; Core Facility; Dermatology; Development; Discipline; Doctor of Medicine; Doctor of Philosophy; Earth science; Ecology; Educational workshop; Effectiveness; Environmental Health; Epidemiology; Evaluation; experience; Family health status; Federal Government; Funding; Government Agencies; Grant; Group Meetings; Health Policy; Heart; informant; interest; Interview; K-Series Research Career Programs; Leadership; Local Government; Medicine; meetings; member; Mentors; National Institute of Environmental Health Sciences; Neurology; New York City; Newsletter; Pediatrics; Persons; Physicians; Pilot Projects; Planet Earth; Policies; population health; Preparation; Press Releases; Process; Productivity; Program Development; programs; Progress Reports; Psychiatry; Public Health; Public Health Schools; Radiation Oncology; Recording of previous events; remediation; Research; Research Personnel; Schools; Science; Services; Site; Structure; Supervision; Surgeon; Surveys; symposium; Translating; Universities; Vision; Work; working group; ","Administrative Core","009089","EHS","Environmental Health Sciences Review Committee ","7562","","21","255830","153499","","409329"
"9672567","P01","HL","5","N","04/26/2019","04/01/2019","03/31/2020","","P01HL136267","","PAR-13-316","5P01HL136267-03","NHLBI:149693\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BIRMINGHAM","UNITED STATES","","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","ADMINISTRATIVE CORE (A) PROJECT NARRATIVE  The Administrative Core 1) facilitates the business requirements associated with the PPG, 2) fosters scientific progress and coordination among the various projects and cores including coordination of scientific activities, communication, and travel among the three sites that are involved, 3) promotes professional development and expansion of ideas for the entire research team, and 4) provides biostatistical and computing resources for each of the projects.","1869893; ","POLLOCK, DAVID M;","MARIC-BILKAN, CHRISTINE","","","Accounting; Advisory Committees; Alabama; Basic Science; Biochemical; Biology; Biometry; Blood Pressure; blood pressure regulation; Businesses; Cardiovascular Diseases; Clinical Sciences; Clinical Trials; Collaborations; Communication; Computers; computing resources; Data; data management; Data Storage and Retrieval; data warehouse; design; Development; Diet; Endothelin; Ensure; Excretory function; Experimental Designs; Faculty; Fostering; Funding Mechanisms; Health Sciences; Hypertension; Infrastructure; Institution; Kidney; Kidney Diseases; Logistics; Manuscripts; Medicine; meetings; Modification; Names; National Heart, Lung, and Blood Institute; nephrogenesis; Nephrology; novel; operation; Pathway interactions; Physiology; Policies; Population Sciences; Preparation; professor; Program Research Project Grants; programs; Progress Reports; Public Health Schools; Publications; Recording of previous events; Research; research data dissemination; Research Methodology; Research Personnel; Schedule; sharing data; Site; Sodium; Sodium Chloride; Statistical Data Interpretation; Students; Texas; Training; Travel; Tubular formation; Universities; Utah; Water; ","Administrative Core","136267","HLBP","Heart, Lung, and Blood Initial Review Group ","8213","","03","132920","16773","","149693"
"9672570","P01","HL","5","N","04/26/2019","04/01/2019","03/31/2020","","P01HL136267","","PAR-13-316","5P01HL136267-03","NHLBI:386676\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BIRMINGHAM","UNITED STATES","","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","PROJECT 2 NARRATIVE  The proposed studies will determine how a key component of the kidney endothelin system is regulated by salt and water intake. Ultimately, these studies are designed to determine how this endothelin system acts on cells to regulate urinary salt and water excretion and blood pressure.","6225753; ","KOHAN, DONALD E;","MARIC-BILKAN, CHRISTINE","","","Acute; Address; Affect; Animals; Area; autocrine; Blood Pressure; blood pressure regulation; Body Fluids; cell type; Cells; Chronic; Cilia; Clinical Trials; design; Diuresis; Diuretics; Duct (organ) structure; Endothelin; Endothelin-1; Endothelin-3; Excretory function; fluid flow; Homeostasis; Human; Hypertension; Impairment; Investigation; Kidney; Knock-out; Link; Liquid substance; Mediating; Messenger RNA; Modeling; Natriuresis; Nitric Oxide; Nitric Oxide Synthase; NOS3 gene; novel; P2Y2 receptor; Pathway interactions; Physiological; PKD2 protein; Play; polycystic kidney disease 1 protein; Process; Production; Protein Isoforms; Purinergic P2 Receptors; Purinoceptor; Rattus; receptor; Regulation; Renal function; response; Role; salt intake; salt sensitive hypertension; saluretic; Signal Pathway; Signal Transduction; Sodium; Sodium Chloride; success; System; Testing; urinary; Water; Water consumption; ","Integrated control of endothelin production in the collecting duct","136267","HLBP","Heart, Lung, and Blood Initial Review Group ","8216","","03","279355","107321","","386676"
"9672924","U19","AI","5","N","04/25/2019","04/01/2019","03/31/2020","","U19AI089688","","RFA-AI-15-056","5U19AI089688-10","NIAID:369686\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","The Malaria Evolution in South Asia International Center of Excellence for Malaria Research (MESA-ICEMR) will study the changing nature of malaria parasites in India. We are particularly interested in initiation of drug resistance as well as the pathways and ecological barriers to dissemination of such traits. Teams at unique sites spanning India will study malaria parasites in human hosts, mosquito vectors, and controlled laboratory studies after adaptation to answer these questions.","6074776; ","RATHOD, PRADIPSINH K.;","","","","Administrator; Africa; Agreement; Area; Asia; base; career; Cells; Characteristics; Clinical; Clinical Research; Collaborations; Communication; Community Surveys; Consult; Contracts; Coordination and Collaboration; Culicidae; Development; Disease; Dissection; Drug resistance; Drug usage; Employee; Ensure; Environment; Evolution; experimental study; Field Workers; Financial compensation; flexibility; Geography; Goals; Government; Government Agencies; Growth; Human; human disease; Immunity; India; Individual; Infrastructure; Institutes; interest; International; international center; Knowledge; Laboratories; Laboratory Study; Lead; Leadership; Malaria; Medical Research; medical schools; member; Morbidity - disease rate; mortality; Movement; National Institute of Allergy and Infectious Disease; Nature; novel; operation; Parasites; Pathology; Pathway interactions; Pattern; performance site; Personal Growth; Phenotype; Plasmodium falciparum; Plasmodium vivax; Population; professional atmosphere; programs; Recording of previous events; recruit; Regulation; Reporting; Research; Resources; response; Rewards; sample collection; Sampling; Scientist; service providers; Shapes; sharing data; Site; sound; Structure; Supervision; Time; Training; trait; transmission process; United States National Institutes of Health; Universities; urban area; Variant; vector; vector mosquito; Vendor; Washington; Work; ","Administrative Core","089688","ZAI1","Special Emphasis Panel ","5495","","10","312887","98744","","369686"
"9674509","P20","GM","5","N","04/26/2019","04/01/2019","03/31/2020","","P20GM103440","","PAR-14-233","5P20GM103440-17","NIGMS:623104\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","Administrative Core - Project Narrative The Administrative Core provides logistical support and financial management to all NV INBRE programs and activities to facilitate the training of the next generation of biomedical researchers, enhance nationally- competitive biomedical research in Nevada, and ultimately improve the health of Nevadans.","1896564; ","KENYON, JAMES L;","","","","Advisory Committees; Bioinformatics; Biomedical Research; cell growth; Communication; Core Facility; Databases; Development; Differentiation and Growth; Education; Educational process of instructing; Evaluation; faculty mentor; faculty research; Funding; Grant; Health; improved; Institution; Link; Logistics; Mentors; Mission; Nevada; next generation; Occupational activity of managing finances; Office of Administrative Management; organizational structure; outreach; outreach program; programs; Reporting; Research; Research Activity; Research Personnel; Research Training; Shapes; Structure; Students; Training; web site; ","Administrative Core","103440","ZGM1","Special Emphasis Panel ","7784","","17","475998","147106","","623104"
"9681421","R21","CA","5","N","04/24/2019","04/01/2019","03/31/2020","395","R21CA226301","HOSPITALS","PAR-16-176","5R21CA226301-02","NCI:168779\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","HOUSTON","UNITED STATES","RADIATION-DIAGNOSTIC/ONCOLOGY","09","800772139","US","578407","UNIVERSITY OF TX MD ANDERSON CAN CTR","TX","770304009","Narrative Use of the novel therapeutic strategy of ?collateral lethality? in response to tumor suppressor deletion is expected to generate an array of cancer drug-targets that have previously been inaccessible to molecular therapeutics. Regardless of the extent of malignancy, transformation and signaling-pathway dysregulation, all normal and cancer cells rely on basic ?housekeeping? functions to remain alive. Unlike molecular therapeutics aimed at activated oncogenes, collateral lethality selectively inhibits these basic functions, providing fresh therapeutic options to patients with even the most highly advanced and metastatic cancers.","10691660; ","MULLER, FLORIAN ;","ARYA, SURESH","04/06/2018","03/31/2020","1p36; Ablation; Acetyl Coenzyme A; Advanced Malignant Neoplasm; Anabolism; Animal Model; Antineoplastic Agents; Antisense Oligonucleotides; base; Biochemical; Biochemical Reaction; Biological; cancer cell; Cancer cell line; cancer genome; cancer type; Categories; Cell Survival; Cells; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Coenzyme A; cofactor; Collaborations; Data; Development; Disseminated Malignant Neoplasm; Doxycycline; Drug Targeting; druggable target; Embryo; Enzymes; epigenetic regulation; Event; Genes; Genetic Databases; genetic information; Genomics; Glioblastoma; Histone Acetylation; Housekeeping; Housekeeping Gene; Immune checkpoint blockade; Immunotherapy; In Vitro; in vivo; interest; Isoenzymes; knock-down; Knock-out; Knockout Mice; lipid metabolism; Luciferases; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammals; melanoma; Metabolic; metabolomics; Methods; Modeling; Molecular; molecular targeted therapies; Mus; Mutation; Neoplasm Metastasis; neoplastic cell; non-invasive imaging; Normal Cell; novel; novel therapeutics; Oncogenes; outcome forecast; Pantothenate kinase; Pathway interactions; patient population; Patients; Pharmacologic Substance; Pharmacology; Play; precision medicine; precision oncology; Protein Acetylation; Protein Isoforms; Proteomics; PTEN gene; Resistance; response; Role; Signal Pathway; Signal Transduction; small hairpin RNA; small molecule; success; Sum; System; targeted treatment; Testing; Therapeutic; therapeutic target; Time; Toxic effect; transcriptomics; tumor; tumor growth; Tumor Suppressor Genes; Tumor Suppressor Proteins; tumor xenograft; tumorigenesis; ","Collateral Deletions Expose Targetable Metabolic Vulnerabilities in the PTEN locus","226301","ZCA1","Special Emphasis Panel ","","","02","105487","63292","168779",""
"9685202","K24","HL","5","N","04/26/2019","04/01/2019","03/31/2020","837","K24HL105493","SCHOOLS OF MEDICINE","PA-14-047","5K24HL105493-10","NHLBI:115363\","OTHER RESEARCH-RELATED","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CHAPEL HILL","UNITED STATES","OTHER HEALTH PROFESSIONS","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because disparities in cardiovascular disease (CVD) and CVD risk factors are dramatic in rural and minority communities with limited access to quality healthcare. In this proposal, we will define assets that already exist in communities to reduce CVD risk and examine how organizational assets and networks evolve and are associated with sustainability of interventions to reduce population CVD risk. Combined with the mentoring component, to train new and early stage researchers to conduct high impact CVD prevention research, the proposed research is highly relevant to NHLBI's mission to enhance the health of patients so that they can live longer and more fulfilling lives.","3117366; ","CORBIE-SMITH, GISELLE ;","FINE, LARRY","09/20/2010","03/31/2020","Address; Alcohol consumption; base; behavior change; Body Weight decreased; Cardiovascular Diseases; cardiovascular disorder prevention; cardiovascular disorder risk; career development; Cholesterol; Clinical Sciences; Collaborations; Color; Communication; Communities; community based participatory research; community setting; County; Dairy Products; Data; design; Development; Development Plans; Diet; Discipline of Nursing; Disease Outcome; Epidemiology; Evaluation; Evidence based intervention; Fatty acid glycerol esters; Foundations; fruits and vegetables; Funding; Future; Geography; Goals; Grant; Health; Health behavior; health care quality; health equity; Health Services Research; Healthcare; improved; Individual; Infrastructure; innovation; Institutes; interest; Intervention; Intervention Studies; Life Style; Maps; Medicine; member; Mentors; Methods; minority communities; Mission; mobile computing; Morbidity - disease rate; mortality; National Heart, Lung, and Blood Institute; next generation; outreach services; Parents; Participant; Pathway Analysis; Patients; Peer Review; Phase; Physical activity; Physical environment; Population; Prevention Research; Prevention strategy; programs; Public Health; public health relevance; Publications; Randomized; Recording of previous events; recruit; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resource Development; Resources; Risk Factors; Risk Reduction; Rural; rural African American; Rural Community; rural setting; salt intake; saturated fat; service programs; social; Social Environment; Testing; theories; Time; Training; Translational Research; Ursidae Family; Weight maintenance regimen; Work; ","Mentoring in community-engaged approaches to address CVD disparities","105493","MPOR","NHLBI Mentored Patient-Oriented Research Review Committee ","","","10","109093","6270","115363",""
"9685239","R01","HL","5","N","04/24/2019","04/01/2019","03/31/2020","838","R01HL126671","","PA-13-302","5R01HL126671-06","NHLBI:395000\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","PUBLIC HEALTH RELEVANCE: ARDS is a common and life-threatening condition affecting over 190,000 Americans per year, 30-50% of whom will die. There are no disease-specific therapies other than supportive care highlighting the urgent need to identify novel mediators that will lead to new therapies. Our group has identified cell-free hemoglobin (Hgb) (Hgb that has escaped from red blood cells) as a potential driver of lung epithelial injury and increased lung permeability in ARDS and have shown that a therapy targeted at the harmful effects of Hgb (acetaminophen) may be beneficial in patients with ARDS; the studies in this proposal could drastically change how we think about and treat patients with ARDS.","8791484; ","BASTARACHE, JULIE ANNE;","ZHOU, GUOFEI","04/01/2015","03/31/2020","Acetaminophen; Actins; Acute Lung Injury; Acute Renal Failure with Renal Papillary Necrosis; Acute respiratory failure; Address; Adult Respiratory Distress Syndrome; Affect; Albumins; Alveolar; American; Animal Model; Animals; Attenuated; Blood capillaries; Cell Culture Techniques; cell injury; Cell model; Cell Separation; Cells; Chemistry; Clinical; Clinical Trials; clinically relevant; clinically significant; Complement; Control Groups; Critical Illness; Cytoskeleton; Data; Disease; Edema; Electrical Resistance; Electron Spin Resonance Spectroscopy; Environment; Epithelial; Epithelial Cells; Epithelium; Erythrocytes; Exposure to; F2-Isoprostanes; Functional disorder; Future; Gases; Generations; Goals; Hemeproteins; Hemoglobin; Hemorrhage; Human; human model; Imaging Techniques; Impairment; improved; in vivo imaging; inhibitor/antagonist; Injury; innovation; Iron; Life; Lipid Peroxidation; Liquid substance; Lung; lung injury; Measures; Mechanical ventilation; Mediating; Mediator of activation protein; Methemoglobin; Methods; Mitochondria; Modeling; Molecular; monolayer; Morbidity - disease rate; mortality; multidisciplinary; Mus; new therapeutic target; novel; novel therapeutics; Outcome; Oxidants; oxidation; Oxidation-Reduction; Oxidative Stress; Oxides; PARP9 gene; Pathogenicity; Patients; Permeability; Peroxidases; Plasma Proteins; Porphyrins; Pre-Clinical Model; Proteins; public health relevance; Pulmonary Edema; Reactive Oxygen Species; receptor for advanced glycation endproducts; Reducing Agents; Research Personnel; Resources; Role; Sampling; Sepsis; Severities; Supportive care; targeted treatment; Testing; Therapeutic Effect; therapeutic evaluation; Tight Junctions; United States; Ventilator; Ventilator-induced lung injury; Work; ","Hemoglobin in ARDS: a novel mediator of aveolar epithelial cell dysfunction","126671","ZRG1","Special Emphasis Panel ","","","06","250000","145000","395000",""
"9686377","P30","ES","2","N","04/26/2019","04/01/2019","03/31/2020","","P30ES000002","","RFA-ES-18-003","2P30ES000002-56","NIEHS:528489\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BOSTON","UNITED STATES","","07","149617367","US","3212904","HARVARD SCHOOL OF PUBLIC HEALTH","MA","021156028","","1876230; ","WEISSKOPF, MARC G;","","","","Administrator; Advisory Committees; Appointment; Area; career development; Chalk; Communication; Communities; community building; Core Facility; Development; Discipline; Educational workshop; Effectiveness; Ensure; Environmental Exposure; Environmental Health; Evaluation; Feedback; Fostering; Grant; Health; Health Professional; Incubators; Infrastructure; inter-institutional; Leadership; lectures; Medical; meetings; Monitor; multidisciplinary; National Institute of Environmental Health Sciences; Newsletter; operation; outreach; Pilot Projects; Productivity; programs; Public Health Schools; Publications; Recommendation; Reporting; Research; research facility; Research Personnel; Resources; Schools; Science; senior faculty; Shapes; Talents; Translations; Universities; web site; Work; ","Administrative Core","000002","EHS","Environmental Health Sciences Review Committee ","5372","","56","331341","197148","","528489"
"9687430","R01","NR","1","N","04/26/2019","04/26/2019","02/29/2020","361","R01NR018379","SCHOOLS OF NURSING","PA-18-345","1R01NR018379-01","NINR:655490\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NURSING RESEARCH","","DURHAM","UNITED STATES","NONE","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","Project Narrative Promoting improved chronic condition self-management skills is critically important for adolescents and young adults with childhood onset chronic conditions transitioning to adult based care. Peer support interventions are well-suited to address challenges theorized as critical to adolescents and young adults given the importance of peer relationships during this time. We propose a mixed-methods, 5-year randomized controlled trial, that will include 225 AYAs (16-22 years) with childhood onset chronic conditions, to test the Peer i-Coaching for Activated Self-Management Optimization (PICASO) versus an attention control group.","7831172 (contact); 12234567; ","DOCHERTY, SHARRON L (contact); MASLOW, GARY ;","MATOCHA, MARTHA F","04/26/2019","02/29/2024","Address; Adolescence; Adolescent and Young Adult; Adult; Advocacy; Age; Agreement; attentional control; base; Behavior; burden of illness; care systems; Caring; Characteristics; Childhood; Chronic; Chronic Disease; Clinic; Collaborations; Complex; Control Groups; coping; critical period; Data; design; Development; Emotional; Ethnic Origin; experience; Future; Goals; Health; health management; Health Personnel; health related quality of life; Health system; Healthcare; Home environment; improved; Individual; interest; interoperability; Intervention; Interview; intrinsic motivation; Knowledge; Lead; Learning; Life; Life Expectancy; Life Style Modification; Maintenance; Mediator of activation protein; Medical; Medication Management; Methods; mHealth; Modeling; Mood Disorders; Multi-Institutional Clinical Trial; novel; Outcome; Parents; Participant; patient oriented; Patients; peer; peer coaching; peer support; Pharmaceutical Preparations; Preparation; primary outcome; Program Reviews; Provider; psychosocial; Quality of life; Race; Randomized Controlled Trials; Readiness; Regimen; Reporting; Schools; secondary outcome; Secure; Self Care; Self Management; Severity of illness; sex; Site; skills; Symptoms; systematic review; Testing; Text Telephone; Time; Training; Work; ","Peer i-Coaching for Activated Self-management Optimization in Adolescents and Young Adults with Chronic Conditions","018379","ZRG1","Special Emphasis Panel ","","","01","420930","234560","655490",""
"9687727","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:229070\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","PROJECT 5: PROJECT NARRATIVE Chemical oxidation is increasingly being employed to clean-up hazardous waste sites as it is relatively quick and inexpensive, but oxidation of contaminants may result in the formation of toxic transformation products. The overall goal of this research project is to assess the formation, fate and toxicity of transformation products produced by oxidative remediation and to develop approaches for reducing exposure to these potentially toxic transformation products, thereby protecting public health.","8322236; ","SEDLAK, DAVID L.;","","","","Address; Adoption; analog; Aniline; Aromatic Compounds; base; Benzene; Bicarbonates; Biological; Bromides; Chemicals; chemoproteomics; Chlorides; Chlorobenzene; Communities; Development; drinking water; Engineering; Environment; Enzymes; Excision; Exposure to; Family; Fractionation; Goals; ground water; Hazardous Substances; Hazardous Waste Sites; Health; Hydrogen Peroxide; Hydroxyl Radical; improved; In Situ; invention; Knowledge; laboratory experiment; Lead; Liver Microsomes; Mass Spectrum Analysis; Metabolic Activation; Methodology; Methods; Microbe; microorganism; Minerals; Molecular; Nitrogen; NMR Spectroscopy; novel strategies; Nuclear Magnetic Resonance; organic contaminant; Oxidants; oxidation; Performance; Poisons; prevent; Process; Production; prototype; Public Health; Reaction; remediation; Research; Research Personnel; Research Project Grants; Residual state; Resolution; Scheme; screening; Signal Recognition Particle; Site; Soil; Superfund; superfund site; System; Techniques; Technology; Testing; Toluene; Toxic effect; Toxicology; treatment optimization; Treatment Step; Ultraviolet Therapy; Unspecified or Sulfate Ion Sulfates; Water; water quality; water treatment; Xylene; ","Project 5: Oxidative Remediation of Superfund Contaminants","004705","ZES1","Special Emphasis Panel ","5072","","31","150686","78384","","229070"
"9700665","P41","EB","5","N","04/26/2019","03/01/2019","02/29/2020","","P41EB015922","","PAR-17-083","5P41EB015922-22","NIBIB:206945\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","Los Angeles","UNITED STATES","","34","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PROJECT NARRATIVE - ADMINISTRATION CORE The operations of any successful program must be codified and structured so that the various elements, entities and activities of the program work in concert to produce outstanding, ethical and responsible science. The administrative core of the LONIR serves these functions.","6855806; ","TOGA, ARTHUR W;","","","","Advisory Committees; authority; Biomedical Technology; Budgetary Controls; Collaborations; Community Services; Complement; computer network; Computer software; Congresses; Contracts; Counseling; Coupled; Critiques; Databases; Deposition; Development; Educational Activities; Educational workshop; Elements; Ethics; Evaluation; Expenditure; experience; Extramural Activities; Fostering; Funding; Funding Agency; Future; Goals; Grant; Guidelines; Human Resources; improved; Infrastructure; innovation; Institutional Review Boards; Investigation; investigator training; Laboratories; Licensing; Measures; member; Monitor; Nature; neuroimaging; online resource; operation; Peer Review; Performance; Philosophy; Policies; programs; Progress Reports; Publications; Recommendation; Reporting; Research Activity; research and development; Research Personnel; Resource Allocation; resource guides; Resources; Science; Scientist; Services; statistics; Structure; success; System; Technology; technology research and development; tool; Training; Universities; Vision; web site; Work; ","Administration Core","015922","ZEB1","Special Emphasis Panel ","5227","","22","125421","81524","","206945"
"9701963","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:215051\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","","1897308; ","SERWOLD, THOMAS F;","","","","Address; Adipocytes; Adipose tissue; Apoptotic; Applications Grants; Area; Autoimmunity; Beta Cell; Biology; cell behavior; Cell Separation; cell type; Cells; cellular development; Complex; cost efficient; Deposition; Development; Diabetes Mellitus; Dissection; Educational Activities; equipment training; Flow Cytometry; Fluorescence-Activated Cell Sorting; Funding; Gene Expression Regulation; Goals; Hematopoietic; Immunologics; improved; Individual; Inflammation; instrument; instrumentation; Insulin-Dependent Diabetes Mellitus; Islets of Langerhans; Liver; Mediator of activation protein; Metabolic; Methods; Mission; Modernization; Molecular Biology; Muscle; Muscle Cells; Nervous system structure; new technology; Non-Insulin-Dependent Diabetes Mellitus; novel strategies; operation; Pancreas; Population; Proteins; rapid technique; Request for Applications; Research; Research Personnel; response; Retinal; Sampling; screening; Signaling Molecule; Sorting - Cell Movement; Speed; stem cell differentiation; Structure of beta Cell of islet; Technology; technology development; Thymus Gland; Tissues; tool; training opportunity; Update; ","Flow Cytometry Core","036836","ZDK1","Special Emphasis Panel ","7094","","33","127437","87614","","215051"
"9710567","P30","AG","1","N","04/26/2019","04/01/2019","03/31/2020","","P30AG062422","","RFA-AG-19-001","1P30AG062422-01","NIA:275524\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","2095227; ","ROSEN, HOWARD J;","","","","African American; Aging; Alzheimer's Disease; Alzheimer's disease related dementia; American; Appointment; Area; Asian Americans; Asians; Assessment tool; Awareness; base; brain health; California; Cancer Grant Supplements (P30); Caring; Chinese American; Chinese People; Clinic; Clinical; Clinical Research; Code; cohort; Collaborations; Communities; community organizations; Data; Databases; Dementia; dementia care; dementia risk; demographics; Development; Diagnostic; Education; Enrollment; Ensure; Event; Exposure to; Faculty; Frontotemporal Dementia; Funding; global health; Goals; Health Professional; Heterogeneity; Hong Kong; Individual; interest; Language; Latin America; Latino; lectures; Linguistics; Low income; Measures; meetings; member; Mind; Neighborhoods; Nerve Degeneration; Neurodegenerative Disorders; novel strategies; Online Systems; outreach; Participant; Patients; Phenotype; Physicians; Play; Population; Population Heterogeneity; Presenile Alzheimer Dementia; Prevention; Prion Diseases; programs; Publishing; racial and ethnic; ranpirnase; recruit; Research; Research Personnel; San Francisco; Signal Transduction; skills; social; social health determinants; Social isolation; success; Symptoms; tool; Underrepresented Groups; Underrepresented Populations; Underserved Population; ","Core E: Outreach, Recruitment and Engagement Core","062422","ZAG1","Special Emphasis Panel ","5037","","01","171755","103769","","275524"
"9718898","P30","AR","1","N","04/24/2019","04/15/2019","03/31/2020","","P30AR074992","","RFA-AR-19-002","1P30AR074992-01","NIAMS:313250\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","SAINT LOUIS","UNITED STATES","","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","","2477081; ","SILVA, MATTHEW J;","","","","Advisory Committees; Animal Model; Applications Grants; Award; base; Biological; Biological Testing; Biology; Biometry; Collaborations; Communication; Communities; Consult; cost effective; Development; Disease; Electronic Mail; Ensure; Environment; Evaluation; Event; experience; Fostering; Functional disorder; Funding; Genetic Models; Goals; Grant; Interdisciplinary Study; interest; Internal Medicine; Intervention; Leadership; Maintenance; Medicine; member; Mouse Strains; Mus; Musculoskeletal; news; Newsletter; next generation; operation; organizational structure; Orthopedic Surgery procedures; outreach; Performance; programs; Publications; Recording of previous events; Research; Research Design; Research Personnel; Resources; Saints; Seeds; Series; Services; social media; Social Network; symposium; synergism; Time; Universities; University resources; Washington; web site; Work; ","Administrative Core","074992","ZAR1","Special Emphasis Panel ","5346","","01","200000","113250","","313250"
"9729349","U19","AI","2","N","04/22/2019","04/25/2019","03/31/2020","","U19AI110818","","RFA-AI-18-004","2U19AI110818-06","NIAID:639146\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","","07","623544785","US","10021177","BROAD INSTITUTE, INC.","MA","021421027","","9367266; ","CUOMO, CHRISTINA A;","","","","Address; analytical tool; biodefense; Bioinformatics; bioinformatics resource; Biological; Biotechnology; Cells; Clinical Data; Cloud Computing; cluster computing; combat; Communicable Diseases; Communities; Computer Analysis; computer infrastructure; Computer software; Computing Methodologies; Custom; Data; Data Analyses; data management; Data Quality; Data Set; Data Storage and Retrieval; Development; Diagnosis; Documentation; drug sensitivity; Ensure; experience; flexibility; Funding; Generations; genomic data; Genomics; Goals; Human Resources; Hybrids; improved; Individual; Infection; Infectious Diseases Research; Infrastructure; innovation; Institutes; Institutional Review Boards; Metadata; Metagenomics; method development; Methods; Microbe; National Institute of Allergy and Infectious Disease; new technology; novel; novel strategies; Parasites; pathogen; Population; prevent; Process; programs; Protocols documentation; quality assurance; Quality Control; Reagent; Recording of previous events; repository; Research; Research Project Grants; Resources; Sampling; Scientist; Secure; Sequence Analysis; Software Engineering; System; Technology; Time; tool; Training; transmission process; Update; Variant; vector; Viral; Virulence; Work; ","Data Management, Analysis, and Resources Dissemination Core","110818","ZAI1","Special Emphasis Panel ","5976","","06","461838","177308","","639146"
"9737244","R01","HL","1","N","04/19/2019","04/22/2019","03/31/2020","837","R01HL141080","SCHOOLS OF MEDICINE","PA-18-484","1R01HL141080-01A1","NHLBI:783327\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PITTSBURGH","UNITED STATES","INTERNAL MEDICINE/MEDICINE","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","Project Narrative. Sickle Cell Disease (SCD) affects 100,000 Americans and millions world-wide. Acute chest syndrome (ACS), a type of acute lung injury, is one of the leading causes of mortality in SCD but there is no available treatment to stop the progression of ACS. This study will identify how small extracellular vesicles (exosomes) are released from platelets in SCD, how these exosomes promote ACS, and how the exosome release and signaling can be regulated using targeted-drug delivery to stop the progression of ACS in SCD.","10302929; 10262104; 8963554; 10961272 (contact); ","NEAL, MATTHEW D.; SCOTT, MELANIE J.; SEN GUPTA, ANIRBAN ; SUNDD, PRITHU  (contact);","OCHOCINSKA, MARGARET J","04/22/2019","03/31/2023","Acute; acute chest syndrome; Acute Lung Injury; Affect; American; arteriole; Attenuated; Binding; Biochemical; Biocompatible Materials; Blood; Blood flow; Blood Platelets; CASP1 gene; Drug Delivery Systems; Drug Targeting; Dyes; Encapsulated; exosome; extracellular vesicles; Functional disorder; Hemorrhage; high risk; human disease; Image; In Vitro; in vivo; Inflammasome; Injury; innovation; Interleukin-1 beta; Interleukin-1 Receptors; interleukin-1beta-converting enzyme inhibitor; Lipopolysaccharides; live cell imaging; Lung; lung imaging; lung injury; Mediating; Microcirculation; Microfluidics; Microscopy; Modeling; mortality; multi-photon; Mus; nanomedicine; nanoparticle; neutrophil; novel; novel therapeutics; Pathogenesis; Patients; peripheral blood; Physiological; Platelet aggregation; Platelet Count measurement; prevent; recruit; Role; Secondary to; Sickle Cell Anemia; Signal Transduction; Site; Testing; Thrombocytopenia; Thrombosis; Time; TLR4 gene; Transgenic Organisms; ","Mechanisms of platelet exosome-mediated acute chest syndrome in sickle cell disease","141080","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","A1","01","545927","237400","783327",""
"9738369","R01","NR","1","N","04/25/2019","04/25/2019","02/29/2020","361","R01NR017853","SCHOOLS OF NURSING","PA-18-141","1R01NR017853-01A1","NINR:564960\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NURSING RESEARCH","","PHILADELPHIA","UNITED STATES","OTHER HEALTH PROFESSIONS","02","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","PROJECT NARRATIVE Unrelieved pain is among the top symptoms producing the greatest negative impact on cancer patients' quality of life. One in three patients with cancer experience moderate to severe pain. This application will generate new knowledge about pain self-management among cancer outpatients who are prescribed opioids.","8753914; ","MEGHANI, SALIMAH H.;","HUSS, KAREN","04/25/2019","02/29/2024","Accident and Emergency department; addiction; Address; Adherence; Adverse effects; African American; Age; American; Analgesics; Area; Attention; base; Belief; Breakthrough Pain; cancer diagnosis; cancer pain; Cancer Pain Management; Cancer Patient; Cancer Science; cancer therapy; Caring; chronic pain; Clinical; clinical predictors; Complementary and alternative medicine; Constipation; cost; daily pain; Data; design; disparity reduction; Dose; Event; Exclusion Criteria; experience; Flare; health care service utilization; health disparity; health management; health related quality of life; Health Services; Healthcare; Hospitalization; Human; improved; Individual; Intervention; Knowledge; knowledge translation; Longitudinal Studies; Love; Malignant Neoplasms; Monitor; National Institute of Nursing Research; non-opioid analgesic; oncology; Opioid; Opioid Analgesics; opioid misuse; opioid therapy; opioid use; Outcome; Outpatients; Pain; Pain management; Pain Research; pain self-management; Patient Outcomes Assessments; Patient Self-Report; Patients; Pattern; Persons; Pharmaceutical Preparations; Policies; prescription opioid; Prospective cohort study; Public Health; Quality of life; Race; racial disparity; recruit; Reporting; Research; Roter; Schedule; Self Management; Services; Severities; sex; Side; sleep health; socioeconomics; Symptoms; System; systematic review; Testing; therapy development; Time; time use; United States National Institutes of Health; Woman; ","The Rote of Opioid Adherence Profiles in Cancer Pain Self-Management and Outcomes","017853","CMPC","Clinical Management of Patients in Community-based Settings Study Section ","","A1","01","349459","215501","564960",""
"9747095","IK2","VA","5","N","04/26/2019","03/01/2019","02/29/2020","999","IK2HX002064","","RFA-HX-15-029","5IK2HX002064-04","","OTHERS","2019","Veterans Affairs","","MADISON","UNITED STATES","","02","086683091","US","481071","WM S. MIDDLETON MEMORIAL VETERANS HOSP","WI","537052254","More than 300,000 Veterans are severely obese. These Veterans exert significant costs on the VA system, experience poorer quality of life, and have shortened lifespans. Bariatric surgery is the most effective treatment for severe obesity for weight loss, comorbidity resolution, and quality of life. Bariatric surgery is supported as a treatment option by many national societies, including those representing primary care and endocrinology. However, less than 1% of Veterans who qualify for bariatric surgery undergo it. Reasons for low utilization are unclear, although our preliminary research suggests that there are various patient, provider and system level barriers to severe obesity care. This CDA proposal addresses the VA's urgent need to 1) understand the barriers to severe obesity care within VA; 2) test interventions designed to improve communication between providers and Veterans regarding severe obesity treatment options, including bariatric surgery and behavioral weight loss strategies; and 3) characterize management practices surrounding severe obesity care within VA.","8254475; ","FUNK, LUKE M;","","03/01/2016","02/28/2021","Address; Algorithms; Area; Attitude; Award; bariatric surgery; Bariatrics; barrier to care; Behavior Therapy; Behavioral; Body mass index; Body Weight decreased; Cardiovascular Diseases; care providers; career; career development; Caring; Cause of Death; Clinical; Communication; Communication Tools; Comorbidity; Complication; Computerized Patient Records; Consultations; cost; Data; Decision Making; design; Diabetes Mellitus; Diet; Doctor of Medicine; Educational workshop; effective intervention; effective therapy; Effectiveness; Effectiveness of Interventions; Elements; Endocrinology; Engineering; Evaluation; Exercise; experience; Face; Funding; Goals; Grant; Health; health administration; Health behavior; Health Promotion; Health Services Research; Healthcare Systems; high risk; Human; improved; interest; Interview; Lead; learning strategy; Longevity; Master of Public Health; Medical; member; Mentors; Mentorship; Metabolic; Methods; Monitor; Morbid Obesity; mortality; Nurses; Obesity; obesity treatment; Operative Surgical Procedures; Patient Care; Patient Preferences; Patients; Perception; Physiological; Practice Management; Prevention; Primary Health Care; programs; Provider; Qualitative Research; Quality of life; Randomized Controlled Trials; Recommendation; Research; Research Activity; Research Design; Resolution; Risk; Sampling; shared decision making; Societies; Specific qualifier value; Standardization; Structure; Surgeon; Surveys; symposium; System; system-level barriers; systematic review; Testing; therapy design; Training; Training Activity; treatment choice; treatment optimization; Veterans; Wages; Weight; Weight maintenance regimen; Work; ","Identifying and Addressing Barriers to Bariatric Surgery within VA","002064","CDA0","HSR&D Career Development Award  ","","","04","","","",""
"9756517","F31","HL","1","N","03/23/2019","04/01/2019","03/31/2020","838","F31HL147397","SCHOOLS OF MEDICINE","PA-18-671","1F31HL147397-01","NHLBI:45016\","TRAINING, INDIVIDUAL","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","604483045","US","894901","BOSTON UNIVERSITY MEDICAL CAMPUS","MA","021182841","Project Narrative Bacterial pneumonia is a vital public health problem which is common in children and the elderly. In this study, we propose that the remodeling of alveolar macrophage's resilience from previous respiratory infections is an important mechanism whereby young to middle-aged adults are protected from developing pneumonia. The proposed studies will result in a better understanding of the observed immunity that naturally occurs post-childhood, and will provide a better understanding of the mechanism governing tissue resilience, and result in novel strategies to identify and protect lungs that are more vulnerable to pneumonia.","14680761; ","ARAFA, EMAD ;","CALER, ELISABET V","04/01/2019","03/31/2022","adaptive immunity; Address; Adult; Age; Aging; alveolar bone; Alveolar Macrophages; Antibody-mediated protection; Apoptosis; arm; Bacterial Pneumonia; Biology; Blocking Antibodies; Bone Marrow; Cause of Death; Cell Separation; Cells; Cessation of life; Child; Childhood; Data; Disease; Elderly; Equilibrium; experience; Exposure to; gain of function; Gene Expression; Genetically Engineered Mouse; Health; Hematopoiesis; Hospitalization; Host Defense; Immune response; Immunity; Immunologic Memory; improved; In Vitro; in vivo; Infection; Inflammation; Interferon Gamma Receptor Complex; Interferon Type II; Investigation; Knowledge; Lung; Lung infections; macrophage; memory CD4 T lymphocyte; Microbe; middle age; monocyte; Morbidity - disease rate; Mus; Natural Immunity; Necrosis; novel strategies; pathogen; Pathogenesis; pathogenic microbe; Pathway interactions; Phenotype; Pneumococcal Infections; Pneumonia; Predisposition; prevent; progenitor; Public Health; Race; Recombinant Cytokines; Recombinants; recombinase-mediated cassette exchange; Recovery; recruit; resilience; Resolution; respiratory; Respiratory Tract Infections; response; Rest; Role; Severities; Signal Transduction; Streptococcus pneumoniae; System; Testing; Tissues; Training; transcriptome sequencing; Vaccine Design; Yolk Sac; ","Pneumonia and Alveolar Macrophage Resilience","147397","ZRG1","Special Emphasis Panel ","","","01","45016","","45016",""
"9760594","F31","HL","1","N","04/10/2019","04/10/2019","04/09/2020","837","F31HL147438","GRADUATE SCHOOLS","PA-18-671","1F31HL147438-01","NHLBI:38617\","TRAINING, INDIVIDUAL","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BLACKSBURG","UNITED STATES","BIOLOGY","09","003137015","US","8968001","VIRGINIA POLYTECHNIC INST AND ST UNIV","VA","240616100","Project Narrative An improved understanding of how extracellular electrolytes affect cardiac mechanical and metabolic function is critical to improving survival following cardiac arrest. The ultimate goal of this project is to lay the foundation for creating IV-fluids optimized to improve cardiac function following cardiac arrest, potentially providing a low- cost therapeutic option for victims of cardiac arrest and their providers.","15583798; ","KING, DAVID RYAN;","HUANG, LI-SHIN","04/10/2019","04/09/2021","Acute; Affect; Arrhythmia; Blood; Blood Pressure; Body Fluids; Calcium; Cardiac; Cardiac Electrophysiologic Techniques; cardioprotection; Cardiopulmonary Resuscitation; Cells; Chlorides; Clinical; clinically relevant; Contracture; cost; Data; design; Development; Electrolytes; emergency service/first responder; Environment; Event; experimental study; extracellular; falls; Fluid Therapy; Fluorescent Probes; Foundations; Functional disorder; Goals; Heart; Heart Arrest; heart function; Homeostasis; Hospitals; Human; Hypernatremia; Image; Impairment; improved; Incidence; inhibitor/antagonist; Intravenous; Ischemia; IV Fluid; Learning; Left; Link; Measures; Mechanics; Mediating; medical schools; Membrane Potentials; Metabolic; metal oxide; Mitochondria; mitochondrial dysfunction; mitochondrial membrane; Modeling; Muscle Cells; Myocardial; Myocardial Ischemia; Nature; Nomenclature; Normal saline; novel; Optics; Outcome; Output; Pathologic; Patients; Perfusion; Phenotype; Physiological; Predisposition; Preparation; pressure; Protocols documentation; Provider; Publishing; Recovery; Research; Resolution; response; Resuscitation; Role; Semiconductors; Sodium; spatiotemporal; System; Techniques; Testing; Therapeutic; Time; Transmission Electron Microscopy; United States; Venous; Ventricular; Virginia; ","Hypernatremic perfusion decreases mechanical and mitochondrial recovery following an ischemic insult","147438","ZRG1","Special Emphasis Panel ","","","01","38617","","38617",""
"9815750","UL1","TR","3","N","04/24/2019","04/24/2019","06/30/2019","350","UL1TR002378","SCHOOLS OF MEDICINE","PA-18-906","3UL1TR002378-02S3","NCATS:34631\","RESEARCH CENTERS","2019","NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES","","ATLANTA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","Program Director/Principal Investigator (Last, First, Middle): Taylor, W. Robert Public Health Relevance This diversity supplement will expand the Georgia CTSA's access to an immigrant Latino population and creates opportunities to increase the Georgia CTSA's portfolio of research and interventions for disproportionally affected communities. This supplement will also assist in developing the independent research career of Natalie D. Hernandez, PhD, MPH with mentorship and training to perform clinical and translational research while also increasing the knowledge on the causes and interventions that can help reduce cervical cancer health disparities. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page","1876688; 1963141; 1916348 (contact); ","BLUMBERG, HENRY M; OFILI, ELIZABETH O.; TAYLOR, WILLIAM ROBERT (contact);","DAVIS NAGEL, JOAN","04/24/2019","06/30/2021","Address; Affect; anticancer research; base; Behavior; cancer diagnosis; cancer health disparity; cancer prevention; career; cervical cancer prevention; Clinical; Clinical Research; Clinical Sciences; Communities; Community Health Aides; contextual factors; Doctor of Philosophy; Ethnic group; experience; Growth; Health; Hispanics; Immigrant; improved; innovation; Intervention; Knowledge; Latina; Malignant neoplasm of cervix uteri; Malignant Neoplasms; Mentorship; Methods; Mexican; Minority; Modeling; outreach; parent grant; Prevention Research; Preventive; Principal Investigator; programs; public health relevance; racial and ethnic; Research; Research Proposals; Role; Rural; rural area; rural underserved; Stress; System; Training; Translational Research; trend; Vulnerable Populations; Woman; Work; ","Georgia CTSA Research Supplement to Promote Diversity in Health-Related Research (Hernandez)","002378","","","","S3","02","34631","","34631",""
"9815779","UL1","TR","3","N","04/23/2019","04/23/2019","06/30/2019","350","UL1TR002378","SCHOOLS OF MEDICINE","PA-18-906","3UL1TR002378-02S2","NCATS:53104\","RESEARCH CENTERS","2019","NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES","","ATLANTA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","Project Narrative Created in response to the Clinical and Translation Science Award Program, UL1 Research Supplement to Promote Diversity in Health Related Research, this application will develop a video-based educational tool for the improvement of genomic comprehension and examine facilitators and barriers to the comprehension for the application of genomic technology for prognostic testing among African-American and rural White men with localized prostate cancer. This innovative community-engagement and mixed-methods proposal extends the research on the comprehension of prognostic genetic testing for localized prostate cancer, to a high-risk, underserved and rural population with longstanding disparities in prostate cancer outcomes.","11296946; 1916348 (contact); ","PHILLIPS, BRADLEY GEORGE; TAYLOR, WILLIAM ROBERT (contact);","DAVIS NAGEL, JOAN","04/23/2019","06/30/2021","Address; African American; Agriculture; Assessment tool; Award; base; cancer health disparity; career development; Clinical Research; Clinical Sciences; clinical translation; Communicable Diseases; Communities; Competence; Comprehension; Decision Making; design; Doctor of Pharmacy; Doctor of Philosophy; Education; Elderly; Epidemiology; ethnic diversity; experience; Faculty; Family health status; Foundations; Generations; Genetic; Genetic screening method; genetic technology; Genome; Genomics; Glycobiology; Health; Health Services Research; Health system; high risk; higher education; improved; innovation; Institutes; Institution; Instruction; instructor; Malignant neoplasm of prostate; Malignant Neoplasms; men; Mentors; Methods; Minority; Mission; Morehouse School of Medicine; Outcome; outreach program; Participant; Pharmacy Schools; Population Heterogeneity; professor; prognostic; prognostic assays; programs; racial and ethnic; racial diversity; recruit; Research; Research Methodology; Research Personnel; Resources; response; Rural; Rural Population; Science; Seasons; Services; socioeconomics; Supervision; symposium; Talents; Technology; tool; Training; Translating; Translational Research; Underserved Population; Universities; Urology; ","Georgia CTSA Research Supplement to Promote Diversity in Health-Related Research (Cobran)","002378","","","","S2","02","53104","","53104",""
"9830777","R01","CA","3","N","04/25/2019","06/01/2018","05/31/2019","396","R01CA197855","SCHOOLS OF DENTISTRY/ORAL HYGN","PA-18-906","3R01CA197855-03S1","NCI:21602\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","SAN FRANCISCO","UNITED STATES","ANATOMY/CELL BIOLOGY","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","PROJECT NARRATIVE Targeting unique features of cancer cells is a preferred therapeutic strategy to inhibit metastatic progression while limiting off-target effects in normal cells. We are testing new ideas on how the unique feature of increased intracellular pH (pHi) in cancers compared with normal adult cells can be targeted to limit cancer metabolism and tumorigenesis. Our expected outcomes are substantial new views on the importance of increased pHi in cancer progression that will impact new therapeutic strategies to limit progression of cancers from different tissue origins and genetic backgrounds.","1865133; ","BARBER, DIANE L;","ESPEY, MICHAEL G","06/01/2016","05/31/2021","6-Phosphofructokinase; Address; Adult; aerobic glycolysis; Affinity; Amino Acid Substitution; Amino Acids; base; Behavior; Biochemistry; Bioinformatics; Biosensor; BRAF gene; cancer cell; Cancer Cluster; cancer subtypes; cancer type; Carbon; cell behavior; Cell Cycle Progression; cell motility; Cell physiology; Cells; Cellular biology; Cellular Morphology; Classification; Consumption; Data; Databases; design; Detection; Disease Progression; Drosophila genus; Dysplasia; Enzymes; Epidermal Growth Factor Receptor; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Genetic; Glucose; Glycolysis; Heterogeneity; Histidine; in vivo; insight; International; Lactate Dehydrogenase; Ligand Binding; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Measures; Mediating; Metabolic; metabolic profile; Metabolism; Methods; Mitochondria; Mitochondrial Matrix; Molecular; Molecular Conformation; molecular dynamics; mouse model; Mutation; Neoplasm Metastasis; neoplastic cell; new therapeutic target; Normal Cell; novel strategies; novel therapeutic intervention; Oncogenes; Oncogenic; Outcome; Oxidative Phosphorylation; PHluorin; Post-Translational Protein Processing; pressure; prognostic; programs; Property; Protein Conformation; protein function; Proteins; Proton-Motive Force; protonation; Publishing; Reporting; Role; sensor; Shapes; Signal Pathway; Somatic Mutation; structural biology; Testing; Therapeutic; Time; Tissues; tool; TP53 gene; tumor; tumor heterogeneity; tumor metabolism; tumor progression; tumorigenesis; tumorigenic; United States National Institutes of Health; Warburg Effect; Work; ","Roles for Intracellular pH Dynamics in Cancer","197855","","","","S1","03","13501","8101","21602",""
"9831095","R01","NS","3","N","04/24/2019","01/01/2019","04/30/2019","853","R01NS067557","SCHOOLS OF MEDICINE","PA-18-591","3R01NS067557-09S1","NINDS:15292\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","NEW YORK","UNITED STATES","NEUROSCIENCES","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","NARRATIVE We identified a gene called SRGAP2A that plays a critical role in coordinating the rate of maturation of both excitatory and inhibitory synapses in the developing cortex. Interestingly, this gene has been duplicated specifically in the human lineage and expression of this human-specific version called SRGAP2C inhibits SRGAP2A function and results in slower synapse maturation and increased number of synapses in cortical neurons. We propose to test the roles of SRGAP2A and its human-specific gene copy in synaptic organization, circuit function and behavioral performance of cortical circuits. ! !","7643399; ","POLLEUX, FRANCK ;","RIDDLE, ROBERT D","01/01/2019","04/30/2019","Address; Area; autism spectrum disorder; Behavior; Behavioral; Binding; Binding Sites; Biochemical; Biological; Brain; cell type; Cells; cognitive function; Complement; Complex; density; Development; Duplicate Genes; Electrophysiology (science); Equilibrium; Evolution; Excitatory Synapse; Funding; GABA-A Receptor; Gene Duplication; gene replacement; Genes; gephyrin; Glutamate Receptor; hippocampal pyramidal neuron; Homeostasis; Homer 1; Human; human embryonic stem cell; human model; in vivo; in vivo imaging; Inhibitory Synapse; interdisciplinary approach; Knockout Mice; Mammals; Molecular; mouse model; Mus; Neocortex; neocortical; neural circuit; Neurodevelopmental Disorder; neurogenesis; Neurons; paralogous gene; Performance; Physiological; Play; Point Mutation; Population; postsynaptic; presynaptic; Property; Proteins; Proteomics; Publishing; Rabies virus; reconstruction; Role; Sampling; scaffold; Scaffolding Protein; Schizophrenia; SH3 Domains; Slice; Specificity; SRGAP2 gene; Synapses; Synaptic plasticity; Synaptic Receptors; synaptogenesis; Testing; Transgenic Mice; two-photon; Vertebral column; ","Cellular and molecular mechanisms underlying the function of SRGAP2 during synaptic development","067557","","","","S1","09","15292","0","15292",""
"9852853","R01","AI","7","N","04/24/2019","04/01/2019","12/31/2019","855","R01AI111943","","PA-18-590","7R01AI111943-05","NIAID:890058\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAN ANTONIO","UNITED STATES","","23","007936834","US","7660801","TEXAS BIOMEDICAL RESEARCH INSTITUTE","TX","782450549","PUBLIC HEALTH RELEVANCE:     Tuberculosis (TB) is the leading cause of death in Human Immunodeficiency Virus (HIV)-infected individuals globally. The majority of HIV-negative individuals infected with Mycobacterium tuberculosis (Mtb) are asymptomatic, considered to be latently infected (LTBI). Large numbers of individuals with LTBI progress to clinically active TB when co-infected with HIV. Antigen-specific T cells are crucial for controlling Mtb infection in humans and lowering of CD4 T cell counts after HIV infection greatly increases the risk of developing TB. However, the mechanisms by which Mtb-specific T cell responses maintain LTBI in the lung, confer protective immunity or result in HIV-induced reactivation of LTBI remain unclear. We hypothesize that co-infection with HIV depletes and/or impairs in the functional capacities of Mtb-specific CD4 and CD8 T cells to drive reactivation of LTBI and that antiretroviral therapy (ART) only partially restores these functions.","8627728 (contact); 8510044; ","KAUSHAL, DEEPAK  (contact); RENGARAJAN, JYOTHI ;","FRANK, DANIEL J","07/01/2015","12/31/2019","Activities of Daily Living; Aerosols; antigen-specific T cells; antiretroviral therapy; Cause of Death; CD4 Lymphocyte Count; CD4 Positive T Lymphocytes; CD8-Positive T-Lymphocytes; Cell Count; Cell Degranulation; Cell physiology; Cells; Cessation of life; Chronic; Clinical; co-infection; Cytoplasmic Granules; cytotoxic; Development; Disease; Dose; Epitopes; Equilibrium; Experimental Animal Model; experimental study; Frequencies; functional disability; functional restoration; Gene Expression Profiling; Goals; Granuloma; HIV; HIV Infections; HIV Seropositivity; HIV/TB; Homing; Human; Immune; Immune response; Immune system; Immunity; Immunologics; immunopathology; Impairment; in vivo; Individual; Infection; Infection Control; Inhalation; insight; Irrigation; Lesion; Lifetime Risk; Lung; Macaca mulatta; Maintenance; Mediating; Memory; MHC Class I Genes; Modeling; Mucous Membrane; Mycobacterium tuberculosis; Nature; nonhuman primate; Pathologic; peripheral blood; Phenotype; Population; preclinical study; Prevalence; Primates; Production; public health relevance; pulmonary granuloma; reactivation from latency; receptor; reconstitution; Regulatory T-Lymphocyte; Risk; Role; Sampling; Site; SIV; Structure of parenchyma of lung; T cell response; T memory cell; T-Cell Proliferation; T-Lymphocyte; Testing; Therapeutic; tool; Tuberculosis; Tuberculosis Vaccines; Vaccine Design; Viral Load result; Whole Blood; ","Perturbation of antigen-specific T cell responses in latent TB/SIV co-infection","111943","ZRG1","Special Emphasis Panel ","","","05","628809","261249","890058",""
"9857479","I01","VA","5","N","04/24/2019","01/01/2019","06/30/2019","999","I01HX001544","","RFA-HX-15-002","5I01HX001544-04","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","IOWA CITY","UNITED STATES","","02","028084333","US","481031","IOWA CITY VA MEDICAL CENTER","IA","522462208","In primary care, where the majority of prescribing occurs, only 4% to 21% of patients achieve the optimum benefit from their medications. In the VHA Patient Aligned Care Team (PACT) model, each pharmacist is responsible for working with 3-5 primary care providers and caring for upwards of 5,000 patients. A single pharmacist cannot review each patient?s medication regimen at each visit and their effort must be focused toward the most appropriate patients. The Triage Algorithm for PACT Pharmacy Services (TAPPS) is a novel health informatics tool that we developed to provide pharmacists with simple real-time clinical reports to help make these decisions. The overall goal of the proposed study is to test the utility of TAPPS in a controlled setting and then to examine the effectiveness of TAPPS in real-world clinical practice using a mixed methods approach. This will include a randomized stepped wedge trial and qualitative interviews with PACT pharmacists to assess the effects of TAPPS on patient care and identify potential barriers to implementation.","10722324; ","LUND, BRIAN C.;","","01/01/2016","06/30/2019","Admission activity; Adverse drug event; Adverse event; Affect; Agreement; Algorithms; Ambulatory Care; base; beneficiary; care providers; Caring; Clinic; Clinical; clinical care; Clinical Data; Clinical Pharmacists; Clinical Pharmacy Service; clinical practice; Clinical Services; Cluster randomized trial; Consult; Controlled Environment; cost; Decision Making; design; Diabetes Mellitus; Disease; Drug Interactions; Effectiveness; effectiveness trial; Electronic Health Record; Emergency department visit; Ensure; Event; experience; Gatekeeping; Goals; Guidelines; Health; health information technology; Hospitalization; Hyperlipidemia; Hypertension; improved; Individual; innovation; Intervention; Interview; Lead; Licensing; Medical center; Medicare; Medication Management; member; Methods; Modeling; non-compliance; novel; Outcome; Outpatients; Patient Care; patient responsibilities; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Pharmaceutical Services; Pharmacists; Pharmacotherapy; Pharmacy facility; Physicians; Play; Positioning Attribute; primary care setting; Primary Health Care; prospective; Public Health Informatics; Randomized; Recommendation; Regimen; Reporting; Risk; risk minimization; Role; Rural; Savings; Services; System; Testing; Time; Triage; trial design; Use Effectiveness; Veterans; Visit; ","An Effectiveness Trial of the Triage Algorithm for PACT Pharmacy Services","001544","HSR5","HSR-5 Health Care System Organization and Delivery ","","","04","","","",""
"9885966","R01","NS","7","N","04/25/2019","03/05/2019","11/30/2019","853","R01NS106170","","PA-18-590","7R01NS106170-02","NINDS:387382\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","DUARTE","UNITED STATES","","32","027176833","US","3058203","BECKMAN RESEARCH INSTITUTE/CITY OF HOPE","CA","910103012","Despite surgery, chemotherapy, and radiotherapy, glioblastoma (GBM) remains an incurable and devastating cancer with a median survival of approximately 15 months following diagnosis. The efficacy of oncolytic virotherapy is a promising treatment for GBM, but oncolytic viruses are rapidly cleared by host immunity, and the viruses have poor reproduction and limited spread in solid tumors. In this application, we generated a novel next-generation oncolytic herpes simplex virus 1 to overcome these barriers by inhibiting clearance from inmate immune cells and enhancing viral spread in tumors, leading to a superior efficacy for GBM treatment.","8869169; ","YU, JIANHUA ;","FOUNTAIN, JANE W","02/01/2018","11/30/2022","Address; Animals; anti-tumor immune response; base; Binding; Biology; Blood - brain barrier anatomy; cancer therapy; Cell Adhesion Molecules; Cell fusion; Cell physiology; Cells; chemotherapy; chimeric antigen receptor; Complex; Cytolysis; cytotoxicity; Data; Diagnosis; Dose; E-Cadherin; Eating; Engineering; Fc Immunoglobulins; FDA approved; Glioblastoma; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Growth; Herpesvirus 1; Immune; immune clearance; Immune response; Immunity; Immunocompetent; Immunoglobulin G; Immunoglobulins; Immunosuppression; improved; in vivo; Infection; Innate Immune Response; interest; Killer Cells; Laboratories; Lead; Ligands; Malignant Neoplasms; Mediating; Minor; Modeling; Mus; N-Cadherin; Names; Natural Killer Cells; neoplastic cell; next generation; NK Cell Activation; Normal Cell; novel; novel strategies; novel therapeutics; oncolytic herpes simplex virus; oncolytic virotherapy; Oncolytic viruses; Operative Surgical Procedures; Paper; particle; Patients; Penetration; Pharmaceutical Preparations; Play; Production; Publications; Publishing; Radiation therapy; receptor; receptor binding; Reporting; Reproduction; Research; Role; Signal Transduction; Site; Solid Neoplasm; Surface; Testing; Toxic effect; trafficking; tumor; tumor microenvironment; Viral; Virotherapy; Virus; ","Overcoming Barriers of Virotherapy by Next-Generation oHSV Expressing E-Cadherin","106170","DT","Developmental Therapeutics Study Section ","","","02","223920","163462","387382",""
"9890047","R01","HS","7","N","04/25/2019","01/01/2019","06/30/2019","226","R01HS025715","","PA-14-291","7R01HS025715-03","AHRQ:198897\","Non-SBIR/STTR RPGs","2018","AGENCY FOR HEALTHCARE RESEARCH AND QUALITY","","NEW YORK","UNITED STATES","","12","041968306","US","5998301","NEW YORK UNIVERSITY","NY","100122300","Project Narrative Nursing care is a core element of patient safety and quality within hospitals, but measures for the quality of nursing care during birth have not been established. This study will break new ground in determining relationships between nursing care during labor and birth, patient outcomes, and health disparities in birth outcomes. Results of this study will provide crucial information that can guide efforts to make health care safer during labor and birth and improve childbirth outcomes in the United States.","8300587; ","LYNDON, AUDREY L;","CHEW, EMILY","09/01/2017","06/30/2020","","Looking at Birth Outcomes and their Relationship to Registered Nurse Staffing","025715","HSQR","Healthcare Patient Safety and Quality Improvement Research ","","","03","","","198897",""
"9901981","R01","MH","3","N","04/26/2019","01/01/2019","06/30/2019","242","R01MH099987","SCHOOLS OF MEDICINE","PA-11-260","3R01MH099987-05S1","NIA:75000\NIMH:64363\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","LA JOLLA","UNITED STATES","PSYCHIATRY","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","PUBLIC HEALTH RELEVANCE: HIV is a serious, chronic, medical disease that affects the lives of more than one million Americans, with half of these individuals being older than 50 years. The goals of the proposed study are to determine the positive psychosocial factors such as resilience, hardiness, optimism, and social engagement as well as biomarkers of aging and of severity of HIV disease that predict physical, cognitive, and psychosocial aging along with self- perceived successful aging in HIV+ individuals compared to non-HIV+ adults. Understanding factors that promote successful aging at an individual level may lead to the development of new preventive and therapeutic interventions aimed at improving quality of life and well-being in adults with HIV.","1876331 (contact); 8527376; ","JESTE, DILIP V. (contact); MOORE, DAVID J;","BROUWERS, PIM","01/09/2013","06/30/2019","Acquired Immunodeficiency Syndrome; Adult; Affect; Age; age effect; aged; Aging; allostatic load; American; antiretroviral therapy; base; Biological; Biological Aging; Biological Markers; blood-based biomarker; C-reactive protein; CCL2 gene; CD4 Positive T Lymphocytes; Cell Count; Chronic; Clinical; Cognitive; cognitive function; cohort; Cohort Effect; Demographic Factors; design; Development; Dimensions; Disease; F2-Isoprostanes; Fibrin fragment D; follow-up; Future; Goals; HIV; Impaired cognition; improved; improved outcome; Individual; Individual Differences; inflammatory marker; Institutes; Insulin Resistance; interest; Interleukin-6; Intervention; Investigation; Laboratories; Lead; Length; Life Expectancy; lifestyle factors; Longitudinal cohort; longitudinal design; Mediator of activation protein; Medical; Methodology; Modeling; National Institute of Mental Health; neurobehavioral; novel; Older Population; optimism; Outcome; Outcome Measure; Participant; Personal Satisfaction; Persons; Physical Function; Physically Handicapped; Plasma; Preventive Intervention; programs; Psychological Factors; psychosocial; Psychosocial Factor; Public Health; public health relevance; Quality of life; recruit; Research; Research Design; resilience; Risk Factors; Role; Severities; Severity of illness; social engagement; Spirituality; Stress; Structure; Surveys; System; Telephone; Telephone Interviews; telomere; Therapeutic Intervention; TNF gene; Variant; Viral Load result; Visit; Work; ","Multi-Dimensional Successful Aging Among HIV-Infected Adults","099987","BSCH","Behavioral and Social Consequences of HIV/AIDS Study Section ","","S1","05","88766","50597","139363",""
"9906450","R56","AI","1","N","04/23/2019","04/23/2019","03/31/2020","855","R56AI139620","SCHOOLS OF MEDICINE","PA-18-484","1R56AI139620-01A1","NIAID:278905\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","DURHAM","UNITED STATES","PATHOLOGY","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","Relevance Statement The emergence of multi-resistance among bacteria infecting surgical site and other skin wounds has made antibiotic treatments largely ineffective. Here we propose to examine the efficacy of utilizing a small mast cell activating peptide as a broad spectrum immunotherapy against bacterial infections.","1888068; ","ABRAHAM, SOMAN N;","LIU, QIAN","04/23/2019","03/31/2020","adaptive immune response; Adjuvant; Affect; Amines; Antibiotic Therapy; Antibiotics; Antimicrobial Resistance; Bacteria; Bacterial Infections; bacterial resistance; Blood Circulation; Burn injury; Cells; Cessation of life; chemokine; Clinical; combat; cost; Coupled; cytokine; Cytoplasmic Granules; Data; Dendritic Cells; Dermal; Dermis; Development; Diabetes Mellitus; diabetic patient; Environment; Exhibits; Explosion; G-Protein-Coupled Receptors; GTP-Binding Protein alpha Subunits, Gs; healing; healthcare-associated infections; Immune; Immune system; Immunotherapeutic agent; Immunotherapy; Infection; Infectious Skin Diseases; injured; interest; Lesion; Location; Malignant Neoplasms; mast cell; mastoparan; Mediating; Mediator of activation protein; Modeling; Mucous Membrane; Multiple Bacterial Drug Resistance; Mus; neutrophil; Neutrophil Infiltration; Operative Surgical Procedures; pathogen; Patients; Peptide Hydrolases; Peptides; Play; Population; Postoperative Period; Process; recruit; Resistance; Resolution; Role; Site; Skin; Skin wound; Specificity; Staphylococcus aureus; Sterility; success; Superbug; Surface; Surgical wound; Time; Tissues; Topical application; Vaccines; Wild Type Mouse; Work; Wound Healing; ","Immunotherapy to combat skin infections","139620","III","Innate Immunity and Inflammation Study Section ","","A1","01","181950","96955","278905",""
"9916039","UG1","DA","3","N","04/26/2019","12/06/2018","05/31/2019","279","UG1DA013714","ORGANIZED RESEARCH UNITS","RFA-DA-15-008","3UG1DA013714-17S6","NIDA:96560\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","SEATTLE","UNITED STATES","MISCELLANEOUS","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","PUBLIC HEALTH RELEVANCE:  Many individuals with substance use disorders (SUDs) do not seek treatment in specialty SUD treatment programs. The integration of SUD treatment into healthcare settings under the ACA-driven healthcare reform requires research to identify, engage, and treat individuals with SUDs more effectively within primary and acute care settings.","1869384 (contact); 8638970; ","DONOVAN, DENNIS  (contact); HATCH-MAILLETTE, MARY AKIKO;","DOBBINS, RONALD","01/10/2001","05/31/2020","Accident and Emergency department; Acute; addiction; Address; adolescent substance use; Affordable Care Act; Alaska; Alcohol abuse; Alcohols; base; Behavior Therapy; behavioral health; Belief; care providers; Caring; chronic care model; Chronic Disease; Clinic; clinical practice; Clinical Research; Clinical Treatment; Clinical Trials Network; cohort; collaborative care; Communities; Community Health Centers; Community Health Planning; Comorbidity; comparative effectiveness; Computerized Medical Record; Data; design; Disease Management; dissemination research; Drug abuse; Early identification; Early Intervention; effective intervention; Effectiveness; effectiveness trial; Electronic Health Record; Evidence based practice; Future; General Population; health care delivery; Health Care Reform; health care settings; Healthcare; Healthcare Systems; high-risk adolescents; Idaho; illicit drug use; Illicit Drugs; Individual; innovation; Institutes; Intervention; Libraries; Link; Location; Medical; Medical center; medical specialties; Medicine; member; Mental Health; Methods; Modeling; Monitor; Montana; National Clinical Trials Network; National Institute of Drug Abuse; operation; Outcome; Pacific Northwest; parity; Patients; Pediatric Hospitals; Pharmacological Treatment; Population Heterogeneity; practice setting; practice-based research network; prescription opioid misuse; Prevalence; prevent; Primary Health Care; Process; programs; Provider; Public Health; public health relevance; Published Comment; randomized trial; Registries; relative effectiveness; Research; research data dissemination; Research Design; Research Methodology; Research Personnel; Research Priority; research study; Resources; screening, brief intervention, referral, and treatment; Source; Substance Use Disorder; System; Technology Transfer; Testing; Tobacco; Training; treatment program; Universities; Washington; Wyoming; ","Clinical Trials Network: Pacific Northwest Node","013714","ZDA1","Special Emphasis Panel ","","S6","17","90060","6500","96560",""
"9918626","U54","NS","3","N","04/22/2019","12/01/2018","11/30/2019","853","U54NS100064","SCHOOLS OF MEDICINE","RFA-NS-16-012","3U54NS100064-03S1","NINDS:37498\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","Los Angeles","UNITED STATES","OPHTHALMOLOGY","34","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","Despite decades of research that have led to an understanding of many causes of epilepsy and yielded over fifteen new antiseizure drugs and novel non-drug therapies, there remain no treatments that prevent epilepsy, nor are there ways to identify and prove such treatments. A major obstacle to research in this area is the fact that studies from single institutions are inadequate to answer the most important questions. The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a proposal for a large, international, multicenter Center without Walls (CWOW) to address this pressing need by using studies of animals and patients with traumatic brain injury (TBI) leading to post-traumatic epilepsy (PTE), to develop the techniques and patient populations necessary to carry out future cost effective full-scale clinical trials of epilepsy prevention therapies.","1887068; 6978554; 1901422; 10517277; 10530926; 6855806 (contact); 2796905; ","ENGEL, JEROME NONE; GALANOPOULOU, ARISTEA S; MOSHE, SOLOMON L.; O'BRIEN, TERENCE JOHN; PITKANEN, ASLA SL; TOGA, ARTHUR W (contact); VESPA, PAUL M;","CHURN, SEVERN BORDEN","01/15/2017","11/30/2021","Address; Animal Model; Animals; Antiepileptogenic; Area; base; biobank; Bioinformatics; Biological Markers; biomarker panel; biomarker performance; Brain Injuries; Clinical; clinical investigation; Clinical Research; Clinical Trials; Collaborations; Communities; Consumer Organizations; cost effective; Databases; design; Development; Diagnosis; Drug usage; Education; Effectiveness; Electrophysiology (science); Epilepsy; Epileptogenesis; experience; fluid percussion injury; Funding; Future; Grant; Human; Image; Injury; Institution; International; Intervention; Investigation; Lateral; Lead; Measures; Methodology; Modeling; Multicenter Trials; multidisciplinary; multimodality; nondrug therapy; novel; patient population; Patients; Performance; personalized medicine; Pharmaceutical Preparations; Plasma; Post-Traumatic Epilepsy; pre-clinical; preclinical study; preclinical trial; prevent; Prevention therapy; Process; programs; Protocols documentation; Randomized; Rattus; recruit; Research; research clinical testing; Research Project Grants; Resources; response; Sensitivity and Specificity; Severities; Standardization; targeted biomarker; TBI Patients; Techniques; Time; tool; translational study; Traumatic Brain Injury; Work; ","The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)","100064","ZNS1","Special Emphasis Panel ","","S1","03","22726","14772","37498",""
"9449410","K24","DA","5","N","04/22/2019","04/01/2019","03/31/2020","279","K24DA036955","","PA-11-195","5K24DA036955-07","NIDA:167241\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","BRONX","UNITED STATES","","14","081266487","US","10053556","ALBERT EINSTEIN COLLEGE OF MEDICINE","NY","104611900","PUBLIC HEALTH RELEVANCE: This application for a K24 mid-career investigator award seeks to provide support to Dr. Chinazo Cunningham to provide excellent mentorship, effective leadership, and expand her current research to include advanced research methods (comparative effectiveness research methods and complex clinical trials methods). Dr. Cunningham will mentor junior investigators in the areas of drug abuse and HIV, with an emphasis on providing mentorship to racial/ethnic minorities and women. Dr. Cunningham will use her existing research project as a foundation to provide much of her mentorship. In addition, expanding her research to include comparative effectiveness research and complex clinical trials focused on opioid use will allow her to conduct new research and provide additional mentorship that can ultimately improve health outcomes of drug users with and at-risk for HIV.","9213243; ","CUNNINGHAM, CHINAZO ;","LIN, YU","04/01/2014","03/31/2020","Abstinence; Address; Adherence; Area; Award; base; Behavior; Blood Tests; Buprenorphine; buprenorphine treatment; career; Caring; CD4 Lymphocyte Count; Clinical Trials; Cocaine; cocaine use; Color; Communities; comparative effectiveness; Complex; contingency management; Control Groups; Data; Databases; Drug abuse; Drug usage; Drug user; effectiveness research; efficacy testing; Enrollment; Ensure; ethnic minority population; Feedback; Foundations; Funding; Goals; Health; health care availability; health disparity; Health Services Accessibility; Healthcare; Highly Active Antiretroviral Therapy; HIV; HIV Infections; HIV risk; illicit opioid; Improve Access; improved; improved outcome; Incentives; Individual; Infrastructure; International; Intervention; Leadership; Medical center; Medical Records; Medicine; Mentors; Mentorship; Methadone; methadone treatment; Methods; Motivation; Neurocognitive; novel strategies; Opiate Addiction; Opioid; opioid agonist therapy; opioid epidemic; opioid use; Opioid user; Outcome; Oxycodone; Participant; patient oriented research; Patients; Performance; Pharmaceutical Preparations; pill; Population; Positioning Attribute; prescription opioid; primary outcome; programs; Public Health; public health relevance; Questionnaires; racial and ethnic; Randomized; Randomized Controlled Trials; Reading; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk; Risk Behaviors; secondary outcome; skills; Smoker; Smoking Cessation Intervention; Standardization; Structure; success; symposium; Testing; therapy adherence; Toxicology; Treatment outcome; trial design; United States National Institutes of Health; Urine; Viral Load result; voucher; Woman; ","Mentoring researchers on drug abuse and HIV","036955","ZRG1","Special Emphasis Panel ","","","07","154853","12388","167241",""
"9627747","U10","CA","2","N","04/23/2019","04/19/2019","02/29/2020","","U10CA180899","","RFA-CA-17-057","2U10CA180899-06","NCI:1935786\","OTHER RESEARCH-RELATED","2019","NATIONAL CANCER INSTITUTE","","OAKLAND","UNITED STATES","","13","128663390","US","1618201","PUBLIC HEALTH INSTITUTE","CA","946074046","","1857551; ","ALONZO, TODD A;","","","","Adolescent; anticancer research; Australia; base; Biology; Canada; Cancer Center; Cancer Patient; Child Support; Childhood; Childhood Cancer Treatment; Clinical; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Design; Collaborations; Communities; Companions; Country; Data; data management; density; design; Development; Diagnosis; Disease; Ensure; Family; Foundations; functional outcomes; Generations; Genomics; Goals; improved; improved outcome; Industry; Infrastructure; innovation; Institution; Interdisciplinary Study; Knowledge; Laboratories; Leadership; Malignant Childhood Neoplasm; member; Methods; Molecular; Monitor; multidisciplinary; New Zealand; organizational structure; Outcome; Patients; Pediatric Hospitals; Pediatric Oncology Group; Performance; Policies; Population Research; programs; Quality of life; Reporting; Research; Research Personnel; research study; Science; sharing data; statistics; Structure; Survivors; Time; translational clinical trial; Translational Research; translational study; United States; Universities; ","COG SDMC - Administrative Core","180899","ZCA1","Special Emphasis Panel ","8346","","06","1839921","253219","","1935786"
"9650504","R37","AI","5","N","04/22/2019","02/01/2019","01/31/2020","855","R37AI066232","","PA-11-260","5R37AI066232-15","NIAID:577200\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LA JOLLA","UNITED STATES","","49","078731668","US","7210001","SALK INSTITUTE FOR BIOLOGICAL STUDIES","CA","920371002","","6138391; ","KAECH, SUSAN M;","KELLY, HALONNA R","05/01/2005","01/31/2023","adaptive immune response; ATAC-seq; B-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation process; Cells; ChIP-seq; Chromatin; chromatin remodeling; combat; Complex; cytokine; Cytokine Signaling; cytotoxic; Data; Deposition; Development; developmental plasticity; Disease; Effector Cell; Epigenetic Process; epigenetic regulation; epigenome; EZH2 gene; Foundations; functional plasticity; Gene Targeting; Genes; Genetic; genetic signature; genome-wide; Genomics; Goals; Grant; Heterogeneity; histone modification; HIV; Homing; Immunologic Memory; in vivo; Infection; insight; Instruction; Longevity; lymph nodes; Mediating; Memory; Modeling; Molecular; Mus; novel; Pathway interactions; Phase; Plasmodium; Polycomb; precursor cell; Principal Investigator; Process; Regulation; Repression; response; Role; Seeds; Signal Pathway; Specific qualifier value; T cell differentiation; T memory cell; T-Cell Development; T-Lymphocyte; Time; transcription factor; tumor; Vaccination; Vaccines; Viral Physiology; virtual; Virus Diseases; Work; ","Regulation of memory CD8 T cell development","066232","NSS","Special Emphasis Panel ","","","15","300000","277200","577200",""
"9658561","R01","NS","5","N","04/23/2019","04/01/2019","03/31/2020","853","R01NS067078","SCHOOLS OF MEDICINE","PA-13-302","5R01NS067078-10","NINDS:370781\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","NEW YORK","UNITED STATES","NEUROLOGY","12","060217502","US","1514803","WEILL MEDICAL COLL OF CORNELL UNIV","NY","100654805","PUBLIC HEALTH RELEVANCE:  The proposed studies will investigate a novel aspect of prohibitin (PHB), related to its role in the ischemic neuronal injury and on mitochondrial functions. The findings will advance our understanding of the fundamental processes governing neuronal survival and death through regulation of mitochondrial dynamics, and have the potential of identifying mitochondria targeted treatment strategies for stroke and other neurological diseases linked to mitochondrial dysfunction.","8852216; ","ZHOU, PING ;","BOSETTI, FRANCESCA","09/15/2009","03/31/2020","Astrocytes; base; Bioenergetics; Brain; Brain Injuries; Brain Ischemia; Cell Death; cell type; Cells; cellular targeting; Cerebral Ischemia; Complex; Confocal Microscopy; Crista ampullaris; deprivation; Development; Electron Microscopy; Failure; Foundations; Free Radicals; Funding; gel electrophoresis; Gene Expression; Gene Transfer; Glial Fibrillary Acidic Protein; Glucose; Hippocampus (Brain); Human; Impairment; improved; in vivo; Infarction; Injury; insight; Intervention; Ischemia; Ischemic Brain Injury; Ischemic Neuronal Injury; Ischemic Preconditioning; Ischemic Stroke; Lead; Link; Mediating; Membrane Fusion; Middle Cerebral Artery Occlusion; Mitochondria; mitochondrial dysfunction; Mitochondrial Proteins; Modeling; Morphology; Mus; nervous system disorder; neuron loss; neuronal survival; Neurons; neuroprotection; new therapeutic target; novel; novel strategies; novel therapeutic intervention; OPA1 gene; Oxygen; Phase; Predisposition; Process; Production; prohibitin; Prosencephalon; protective effect; protein expression; Proteins; Public Health; public health relevance; Reactive Oxygen Species; Regulation; Research; Respiratory Chain; Role; Solid; Stroke; Structure; targeted treatment; Testing; Tetanus Helper Peptide; Tissues; Transgenic Organisms; Translational Research; treatment strategy; ","Role of prohibitin in ischemic brain injury","067078","ANIE","Acute Neural Injury and Epilepsy Study Section ","","","10","218750","152031","370781",""
"9663288","R01","DK","5","N","04/23/2019","04/01/2019","03/31/2020","847","R01DK105517","SCHOOLS OF MEDICINE","PA-13-302","5R01DK105517-04","NIDDK:769738\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","Los Angeles","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","34","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PUBLIC HEALTH RELEVANCE: We propose to examine how variation in specific genes and their interaction with dietary fructose contributes to the accumulation of liver fat, which leads t insulin resistance, one of the hallmarks of type 2 diabetes. Understanding the effect of genetic variation and dietary fructose on the biochemical processes involved in liver fat accumulation can lead to identification of novel drug or interventional targets that may reduce risk for diabetes, non-alcoholic fatty liver disease, and other metabolic disorders.","1947578; ","WATANABE, RICHARD M;","TEFF, KAREN L","04/10/2015","03/31/2021","Affect; base; Biochemical; Biochemical Pathway; Biochemical Process; Data; Deposition; diabetes risk; Diet; Disease; Effectiveness; Environmental Risk Factor; Enzymes; Equilibrium; Family; Fatty acid glycerol esters; Fatty Liver; follow-up; Fructose; fructose-1-phosphate; Functional disorder; gene environment interaction; gene interaction; Genes; Genetic; Genetic screening method; Genetic study; genetic variant; Genetic Variation; genome wide association study; Genotype; Glucokinase; Glucose; glucose uptake; Goals; Grant; Hepatic; Human; Human Genetics; Hydrolysis; in vivo; Individual; insight; Insulin Resistance; Intervention; intravenous glucose tolerance test; Kinetics; Lead; lipid biosynthesis; Liver; Magnetic Resonance Imaging; mathematical model; Measures; Metabolic Diseases; Methods; Mexican Americans; Modeling; multilevel analysis; new therapeutic target; non-alcoholic fatty liver disease; Non-Insulin-Dependent Diabetes Mellitus; novel; novel therapeutics; OGTT; Participant; Pathogenesis; Patients; Phenotype; Phospholipase; Physiological; Physiological Processes; Physiology; Plasma; Process; programs; Proteins; public health relevance; recruit; Regulation; Research; Risk; risk variant; Roentgen Rays; Sampling; Series; Testing; Therapeutic Intervention; trait; Triglycerides; Variant; ","Physiologic Consequence of Genetic Variation","105517","CIDO","Clinical and Integrative Diabetes and Obesity Study Section ","","","04","558966","210772","769738",""
"9668154","R01","GM","5","N","04/25/2019","04/01/2019","03/31/2020","859","R01GM087544","GRADUATE SCHOOLS","PA-13-302","5R01GM087544-09","NIGMS:362730\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","NEW YORK","UNITED STATES","BIOLOGY","12","071037113","US","7056601","ROCKEFELLER UNIVERSITY","NY","100656399","PUBLIC HEALTH RELEVANCE: This proposal describes chemical and biochemical approaches to characterize the roles of protein lipidation in host resistance to microbial infections. Our preliminary studies have demonstrated that S-fatty-acylation of interferon-inducible transmembrane proteins (IFITMs) is required for cellular resistance to influenza virus infection. How S-fatty-acylation controls human IFITM3 function is unclear and will be evaluated in this grant with new chemical biology tools, cell biology assays, in vitro protein biochemistry and infection studies.","9076601; ","HANG, HOWARD C;","NIE, ZHONGZHEN","08/01/2010","03/31/2020","Acyltransferase; Address; Alkynes; Animal Model; Antiviral Agents; Applications Grants; Bacteria; base; Biochemical; bioinformatics tool; Biological; Biological Assay; Biology; biophysical analysis; Cell Line; cell type; Cells; Cellular biology; Chemicals; combat; Complex; Cysteine; Dendritic Cells; Detection; esterase; Eukaryota; Fatty Acids; fatty acylation; Genomics; Goals; Grant; Host Defense; Host resistance; Human; Immunity; In Vitro; Infection; Influenza A virus; influenzavirus; Integral Membrane Protein; Integration Host Factors; Interferons; Label; Laboratories; Life; Ligation; Lipids; Mammalian Cell; Membrane; Metabolic; Methods; microbial; Mus; mutant; novel; Palmitic Acids; palmitoylation; Pathway interactions; Phenotype; predictive tools; Protein Analysis; Protein Biochemistry; Protein Isoforms; Protein S; Proteins; Proteomics; public health relevance; Reagent; reconstitution; Reporter; Resistance; Role; Series; Signal Pathway; Site; tool; Virus Diseases; Yeasts; ","Studies on Protein Lipidation","087544","SBCB","Synthetic and Biological Chemistry B Study Section ","","","09","214000","148730","362730",""
"9669080","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:38145\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","9879324; ","KELLY, DAVID LEE;","","","","assay development; Automation; Biological; Biological Assay; Cancer Center; Centers of Research Excellence; Chemicals; Computational Biology; computational chemistry; Computer Simulation; Computer software; cost; Data; design; Development; Disease; drug development; drug discovery; Drug Targeting; Effectiveness; Equipment; experimental study; Facility Accesses; Faculty Recruitment; Feedback; Funding; Future; Gene Family; Generations; Genes; Goals; Grant; Health; high throughput screening; Homology Modeling; Image; Imaging technology; Individual; Infrastructure; instrumentation; interest; Investments; Laboratories; Laboratory Research; Lead; lead optimization; Legal patent; Mentors; miniaturize; Mission; Molecular Biology; Molecular Target; Nebraska; new technology; novel; Pathway interactions; Patients; Peer Review; Performance; Positioning Attribute; Postdoctoral Fellow; Procedures; Process; programs; protein folding; Publications; Reagent; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; screening; Services; Signal Pathway; Site; skills training; Small Interfering RNA; small molecule inhibitor; Structure; Students; System; Technical Expertise; Technology; therapeutic target; tool; Training; Training Support; Validation; virtual; Work; ","High-Throughput Screening and Computational Chemistry Core","121316","ZGM1","Special Emphasis Panel ","8784","","02","33043","5102","","38145"
"9672483","K99","EB","5","N","04/26/2019","04/01/2019","03/31/2020","286","K99EB026312","","PA-16-193","5K99EB026312-02","NIBIB:93960\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","BALTIMORE","UNITED STATES","","07","155342439","US","2370003","HUGO W. MOSER RES INST KENNEDY KRIEGER","MD","212051832","Project Narrative The Gadolinium base MRI contrast agents that are routinely used in in the clinics for diagnosing and monitoring multiple sclerosis cannot be used in patients with renal insufficiency and has been found to deposit in the gray matter after repeated administration. We propose to develop the use of D-glucose as a biocompatible contrast agent for imaging MS physiology with MRI via the chemical exchange saturation transfer mechanism. If successful, the proposed study will provide a safer, low cost alternative contrast agent for MRI of MS with the potential to capture lesions at their early stages and bring peace of mind to patients knowing they were given a dose of natural sugar instead of a synthetic compound during a MRI scan.","14340980; ","XU, XIANG ;","LIU, GUOYING","04/01/2018","03/31/2020","Adverse effects; Affect; Award; base; biomaterial compatibility; Blood - brain barrier anatomy; Brain; Brain region; career; career development; Cell Nucleus; Chelating Agents; Chemicals; Chronic; Clinic; Clinical; clinical practice; cohort; contrast enhanced; contrast imaging; Contrast Media; cost; Data; Deposition; Development; Diagnosis; Disease; Disease Progression; Dose; Enhancing Lesion; Event; Evolution; Fibrosis; follow-up; Fund Raising; Gadolinium; Gliosis; Glucose; glucose uptake; Goals; gray matter; human subject; Image; imaging agent; Imaging Techniques; Inflammation; Inflammatory; Infusion procedures; Intravenous; Intravenous infusion procedures; Kidney Diseases; Kidney Failure; Knowledge; Laboratories; Leadership; Lesion; magnetic field; Magnetic Resonance Imaging; Measures; Mentors; Mentorship; Methods; Mind; Minor; Monitor; MRI Scans; Multiple Sclerosis; Multiple Sclerosis Lesions; multiple sclerosis patient; Mus; Nerve Degeneration; nervous system disorder; Noise; outcome forecast; Pathologic; Pathology; Patients; Pattern; peace; Periodicity; Permeability; Phase; Physiology; Process; programs; Protocols documentation; Protons; recruit; remyelination; Renal function; Reporting; Research; Research Proposals; Resolution; Risk; Scanning; Series; Signal Transduction; skills; Students; sugar; Symptoms; T2 weighted imaging; Techniques; Testing; Time; tissue repair; Tissues; Training; Translating; Translations; Treatment Efficacy; tumor; Water; ","Development and Translation of D-glucose as an MRI Contrast Agent for Multiple Sclerosis","026312","ZEB1","Special Emphasis Panel ","","","02","87000","6960","93960",""
"9673773","R01","HL","5","N","04/26/2019","04/01/2019","03/31/2020","837","R01HL137246","SCHOOLS OF MEDICINE","PA-16-160","5R01HL137246-03","NHLBI:732519\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CHICAGO","UNITED STATES","PSYCHIATRY","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","Project Narrative The goals of the proposed study are to test whether LGB women differ significantly from heterosexual women on objective biomarkers of health and identify mechanisms by which sexual minority women are at heightened risk for compromised health. It is hypothesized that discrimination stress and childhood stressors have adverse effects on metabolic, inflammatory, and cardiovascular systems that maintain health. The proposal also aims to identify health promotion behaviors that mitigate these associations to inform tailored preventive and intervention approaches for at-risk women.","1880182; ","KEENAN, KATHRYN ELIZABETH;","CAMPO, REBECCA A","04/01/2017","03/31/2021","Abstinence; Adolescence; adolescent health; Adult; Adverse effects; Affect; Age; Alcohol or Other Drugs use; Attenuated; austin; base; Behavior; Biological Markers; Biometry; Blood Pressure; C-reactive protein; cardiometabolism; Cardiovascular Diseases; Cardiovascular system; Caregivers; Chicago; Childhood; Cholesterol; Chronic; Climate; Collaborations; Communities; Complement; cytokine; Data; Development; Diabetes Mellitus; Discrimination; Disease; emerging adult; Emotional; Environment; experience; Exposure to; Family; Fatty Acids; Frequencies; Funding; girls; Glucose; Goals; Grant; Health; health assessment; health disparity; Health Promotion; Health Psychology; Heart Diseases; Heart Rate; Heterosexuals; high risk; Hydrocortisone; Hypertension; Illinois; Inflammation; Inflammatory; innovation; Insulin; Interleukin-6; Intervention; Interview; Lead; lesbian, gay, bisexual; Link; Lipids; Longitudinal Studies; Measures; Mediating; Mediator of activation protein; Mental Health; Metabolic; Minority; Morbidity - disease rate; mortality; Non-Insulin-Dependent Diabetes Mellitus; Patient Self-Report; peer victimization; Physical activity; physical conditioning; Prejudice; Preventive Intervention; Principal Investigator; prospective; Prospective Studies; protective factors; Psychopathology; racial diversity; Recording of previous events; Reporting; Research Personnel; Risk; Role; Safe Sex; Sampling; Schools; Sex Orientation; sexual minority; social stigma; Stress; stress reactivity; stressor; System; Testing; theories; TNF gene; Trauma; United States National Institutes of Health; Universities; uptake; Vaccination; Vaccines; Vulnerable Populations; waist circumference; Woman; young adult; young woman; Youth; ","Examining biomarkers and mechanisms of health disparities in sexual minority women","137246","ZRG1","Special Emphasis Panel ","","","03","608539","123980","732519",""
"9674510","P20","GM","5","N","04/26/2019","04/01/2019","03/31/2020","","P20GM103440","","PAR-14-233","5P20GM103440-17","NIGMS:882083\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","Developmental Research Project and Pilot Grant Programs ? Narrative Biomedical research opportunities for students and faculty at Nevada universities, colleges, and community colleges are limited by a lack of research infrastructure and funding opportunities, which is unfortunate because many faculty at these institutions are Ph.D. trained with promising research programs and an interest in advancing their research programs and in providing authentic research experiences for students. Our DRP and PG program will increase the research activities at UNR and UNLV and develop researchers and their research projects at Outreach Institutions by providing research funding, experienced mentorship, and resources through bioinformatics and other cores to generate publications, grant funding, and/or new research opportunities for undergraduate students.","8897571; ","BAKER, JONATHAN E.;","","","","Address; Adherence; Applications Grants; Award; base; Bioinformatics; bioinformatics tool; Biomedical Research; Biometry; career development; cell growth; Centers of Research Excellence; Collaborations; college; community college; Data; Development; Differentiation and Growth; Doctor of Philosophy; Educational Curriculum; Educational workshop; experience; Extramural Activities; Faculty; Feedback; Funding; Funding Opportunities; Future; Grant; Institution; inter-institutional; interest; meetings; Mentors; Mentorship; Monitor; Nevada; Outcome; Outcomes Research; outreach; Phase; Program Research Project Grants; programs; Publications; Publishing; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Services; Students; Supervision; Teacher Professional Development; Training; undergraduate student; United States National Institutes of Health; Universities; Writing; ","Developmental Research Project Program","103440","ZGM1","Special Emphasis Panel ","7785","","17","800026","82057","","882083"
"9676979","R34","HL","5","N","04/25/2019","04/01/2019","03/31/2020","838","R34HL136991","SCHOOLS OF MEDICINE","PAR-16-037","5R34HL136991-02","NHLBI:360270\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CHICAGO","UNITED STATES","INTERNAL MEDICINE/MEDICINE","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","PROJECT NARRATIVE This joint collaboration between the asthma investigator teams at the University of Chicago and Northwestern University will plan a major clinical trial that determines whether the macrolide antibiotic azithromycin alters the airway microbiome in moderate to severe adult asthma, and whether this in turn leads to improved clinical con- trol. Our key premise is that understanding how macrolides modulate the airway microbiome may justify the use of macrolides as therapy in select asthma phenotypes. Completion of these aims will prepare us to initiate a future clinical trial to answer whether a macrolide alters the airway microbiome in patients with moderate to severe asthma that in turn improves clinical control.","2073280; 1871026 (contact); ","SMITH, LEWIS J; WHITE, STEVEN R (contact);","NOEL, PATRICIA","04/01/2018","03/31/2020","Adult; Adult asthma; Adverse event; Airway Disease; airway inflammation; Antibiotics; Asthma; asthmatic; asthmatic airway; Azithromycin; Bioinformatics; Biological; Biometry; Biostatistics Core; Budgets; Case Report Form; Certification; Chicago; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; cohort; Collaborations; Collection; Complex; Data; Data Collection; data management; design; disorder control; dysbiosis; Economics; Eligibility Determination; Enrollment; Ensure; Future; Goals; Growth; Health Insurance Portability and Accountability Act; Healthcare; Hospitalization; Human Resources; improved; In Vitro; Inflammatory; Informatics; Informed Consent; Institutional Review Boards; Investigation; Investigational Drugs; Joints; Macrolide Antibiotics; Macrolides; Manuals; Measures; Medical; Metabolic; Methods; microbial; microbiome; microbiome alteration; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Nature; New Drug Approvals; Obstruction; Online Systems; operation; Patients; Pharmaceutical Preparations; Pharmacy facility; Phase; Phenotype; Pilot Projects; pilot trial; Procedures; Protocols documentation; Publishing; Randomized Clinical Trials; Reporting; Research Design; Research Personnel; respiratory microbiome; Respiratory Tract Infections; response; Role; Running; Safety; sharing data; Societies; Specific qualifier value; Specimen; Standardization; Statistical Data Interpretation; Symptoms; System; Taxonomy; Testing; Therapeutic; Time; Training; treatment effect; Universities; Variant; waiver; ","Azithromycin and the airway microbiome in asthma","136991","ZHL1","Special Emphasis Panel ","","","02","269061","91209","360270",""
"9678357","R01","HL","5","N","04/25/2019","04/01/2019","03/31/2020","838","R01HL123544","SCHOOLS OF MEDICINE","PA-13-302","5R01HL123544-05","NHLBI:423750\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NEW YORK","UNITED STATES","INTERNAL MEDICINE/MEDICINE","12","060217502","US","1514803","WEILL MEDICAL COLL OF CORNELL UNIV","NY","100654805","PUBLIC HEALTH RELEVANCE: Pathologic changes in the small airways are central to pathogenesis of chronic obstructive pulmonary disease (COPD), the major smoking-associated lung disease, as they precede the development of emphysema and contribute to progressive irreversible airflow limitation, the hallmark of COPD. This project is aimed at identification and characterization of a novel mechanism of small airway disorder in COPD smokers mediated by smoking-dependent suppression of the fibroblast growth factor receptor (FGFR) 2 signaling, critical for distal lung morphogenesis, in basal stem/progenitor cells (BC) of the airway epithelium. If proven correct, therapeutic strategies aimed at re-activation of the FGFR2 signaling in the small airway BC of COPD smokers could lead to the development of novel therapeutic approaches to prevent progression of COPD-associated small airway disorder at the early stages of disease pathogenesis.","11442011; ","SHAYKHIEV, RENAT ;","POSTOW, LISA","04/15/2015","03/31/2020","Address; Adult; airway epithelium; alveolar destruction; Architecture; Basal Cell; base; Cell physiology; Cells; Chronic Obstructive Airway Disease; Data; Development; Disease; Distal; Elements; Epidermal Growth Factor; Epithelial; Exhibits; FGFR2 gene; Fibroblast Growth Factor; Fibroblast Growth Factor Receptor 2; Fibroblast Growth Factor Receptors; Gene Expression; Goals; Human; In Vitro; in vivo; Injury; Knowledge; Lead; Lentivirus Vector; Lung; lung development; Lung diseases; Maintenance; Mediating; Mesenchyme; Metaplastic; Methodology; Molecular; Morphogenesis; Mus; Natural regeneration; Nature; novel; novel therapeutic intervention; Obstruction; overexpression; Pathogenesis; Pathologic; Pathway interactions; Patients; Phenotype; prevent; Process; progenitor; public health relevance; Pulmonary Emphysema; Regulation; repaired; Respiratory physiology; response to injury; restoration; Role; Signal Transduction; Smoker; Smoking; smoking addiction; stem; Stem cells; Testing; Therapeutic; Transforming Growth Factor beta; ","Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD","123544","LIRR","Lung Injury, Repair, and Remodeling Study Section ","","","05","250000","173750","423750",""
"9687714","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:110577\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","CORE A: PROJECT NARRATIVE The Center Directors will manage and coordinate the overall operation of the Center, ensuring that all fiscal and programmatic goals are met and that our progress is communicated through reporting in meetings, presentations, manuscripts, and through our web page and social media. The Center Manager will coordinate the University's support of our financial management and administrative support needs. The input of our External Scientific Advisory Board will provide outside peer-review of our work.","1883460; ","SMITH, MARTYN T;","","","","Accounting; Address; Award; Biomedical Engineering; Businesses; Cancer Research Project; cohesion; Collaborations; Communication; Data Collection; Development; Discipline; Ensure; Environment; Environmental Engineering technology; Financial Support; Fostering; Goals; Group Meetings; Human Resources; Individual; Information Centers; insight; International Agency for Research on Cancer; Internet; Interview; Knowledge; Lead; Leadership; Logistics; malignant breast neoplasm; Manuscripts; meetings; member; Monitor; National Institute of Environmental Health Sciences; news; Occupational activity of managing finances; operation; Paper; peer; Peer Review; Poisons; professor; programs; Public Health; Publishing; Reporting; Research; Research Activity; Research Personnel; Resolution; Resources; Role; Science; Secure; Services; Signal Recognition Particle; social media; Specialist; Speed; success; Superfund; symposium; synergism; Time; Toxicology; Training; Training Activity; Travel; Universities; Update; web page; web site; Work; ","Core A: Administration Core","004705","ZES1","Special Emphasis Panel ","5064","","31","70687","39890","","110577"
"9687722","P42","ES","5","N","04/22/2019","04/01/2019","03/31/2020","","P42ES004705","","RFA-ES-15-019","5P42ES004705-31","NIEHS:233374\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BERKELEY","UNITED STATES","","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947045940","PROJECT 2: NARRATIVE We propose a comprehensive exposomic approach to characterize the dose-dependent effects of arsenic, benzene, trichloroethene, formaldehyde and polycyclic aromatic hydrocarbons on the endocrine system, specifically on the glucocorticoid and sex steroid pathways, in cellular and animal models, and most importantly in exposed human subjects from well-designed epidemiological studies. Findings will fill gaps in the published data regarding the potential endocrine disrupting and stress inducing effects of these chemicals and could have broad implications for risk assessment and policy.","1883460; ","SMITH, MARTYN T;","","","","Address; Adipocytes; Adrenal Cortex Hormones; Adverse effects; Agonist; Androgen Receptor; androgenic; Androgens; Animal Model; Aromatase; Aromatic Polycyclic Hydrocarbons; Arsenic; base; Benzene; Benzo(a)pyrene; Binding; Biological; biological adaptation to stress; Biological Assay; Biological Markers; Blood Cells; carcinogenesis; carcinogenicity; Cell Line; Cell model; cell type; Cells; Chemicals; Chronic; Data; design; Dexamethasone; Dose; Endocrine; Endocrine disruption; Endocrine system; Environment; environmental chemical; Environmental Risk Factor; environmental stressor; epidemiology study; Epithelial Cells; estrogen disruption; Estrogen Receptors; estrogenic; estrogenic activity; Estrogens; exposed human population; Exposure to; Formaldehyde; Functional disorder; Gene Targeting; Glucocorticoid Receptor; glucocorticoid receptor alpha; Glucocorticoids; Glucose; Goals; Gonadal Steroid Hormones; Health; Hepatocyte; Hormones; Human; human subject; Hydrocortisone; In Vitro; in vitro Assay; in vivo; leydig interstitial cell; Life; Lipids; Liver; Lung; male; Mammalian Cell; Mass Spectrum Analysis; Measures; Metabolic; metabolomics; Modeling; monomethylarsonic acid; Mus; muscle form; neurobehavioral; non-genetic; novel; novel strategies; Obesity; Pathway interactions; Physiological; Plasma; Poisons; Policies; Population; Production; Psychosocial Stress; Publishing; receptor; receptor expression; Receptor Signaling; recruit; reproductive; response; Response Elements; Risk; Risk Assessment; screening; Signal Recognition Particle; Signal Transduction; social; Spleen; Steroid biosynthesis; steroid hormone; Steroids; Stress; Superfund; superfund chemical; tissue biomarkers; Tissues; transcriptome; Trichloroethylene; ","Project 2: Exposomics of Endocrine Disruption","004705","ZES1","Special Emphasis Panel ","5069","","31","166311","67063","","233374"
"9689050","R01","HD","5","N","04/26/2019","04/01/2019","03/31/2020","865","R01HD087672","SCHOOLS OF ARTS AND SCIENCES","PA-13-302","5R01HD087672-04","NICHD:315357\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","NEW YORK","UNITED STATES","PSYCHOLOGY","12","041968306","US","5998301","NEW YORK UNIVERSITY","NY","100122300","PUBLIC HEALTH RELEVANCE: The persistent underrepresentation of women in science limits girls' opportunities for cognitive development and economic attainment and-due to the growing number of households relying on the sole income of a female earner-contributes to child poverty and its concomitant negative effects on child development. This project will develop new strategies for addressing the persistent gender gap in science achievement by targeting the mechanisms by which maladaptive beliefs that interfere with achievement are transmitted via language. This research will identify new intervention strategies to target these mechanisms to improve female students' attainment in science.","10313854; ","RHODES, MARJORIE ;","MANN KOEPKE, KATHY M","04/15/2016","03/31/2021","Achievement; Address; Adult; Attitude; base; Behavior; Behavioral; Belief; Belief System; boys; Categories; Child; Child Behavior; Child Development; Child Health; Child Language; child poverty; Cognitive; cognitive development; Conceptions; Correlation Studies; Cues; Economics; Educational Models; Emotional; Engineering; experience; experimental study; Female; Future; Gender; Generations; Generic Drugs; girls; Hearing; Household; improved; Income; informal learning; Institution; Intervention; intervention program; Language; Lead; Linguistics; Link; Mediating; Parent-Child Relations; Parents; Participant; Persons; Procedures; Process; Production; programs; public health relevance; Research; Science; Science, Technology, Engineering and Mathematics; Scientist; Self-Examination; Stereotyping; Students; success; Talents; Testing; Time; transmission process; Underachievement; Woman; Work; ","?The Linguistic Transmission of Maladaptive Beliefs?","087672","CP","Cognition and Perception Study Section ","","","04","217994","97363","315357",""
"9689055","R01","HL","5","N","04/25/2019","04/01/2019","03/31/2020","838","R01HL123797","SCHOOLS OF MEDICINE","PA-13-302","5R01HL123797-05","NHLBI:649583\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","Chicago","UNITED STATES","PEDIATRICS","07","098987217","US","577703","UNIVERSITY OF ILLINOIS AT CHICAGO","IL","606124305","PUBLIC HEALTH RELEVANCE: Asthma Action at Erie Trial Support for community health worker (CHW) interventions is increasing rapidly despite an incomplete evidence base. This study uses a rigorous study design to determine the efficacy of a CHW home asthma intervention integrated into the clinic for high-risk children with asthma. This trial will provide clarity as to the expected effect size, cost savings, and resources needed to integrate asthma CHWs into clinical practice.","8246050; ","MARTIN, MOLLY A;","FREEMER, MICHELLE M","04/01/2015","03/31/2020","Address; Adherence; Adopted; Advocate; African American; arm; Asthma; base; Behavior Therapy; Behavioral; Behavioral Genetics; Caring; Case Manager; Chicago; Child; Childhood Asthma; Clinic; Clinical; clinical practice; clinically relevant; combat; Communities; Community Health Aides; cost; cost effectiveness; Cost Savings; cultural competence; Education; Educational Intervention; efficacy testing; Ensure; Equipment; evidence base; experience; Family; Federally Qualified Health Center; Guidelines; Health; health care availability; Health education; Health Personnel; Health Services; Health Services Accessibility; Healthcare Systems; high risk; Home environment; improved; Individual; instrument; Intervention; Intervention Trial; Lead; Life; Low income; Maintenance; Measures; Medical; medication compliance; Mental Depression; Mental Health; Minority; minority children; Modeling; Modification; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Outcome; Participant; Patients; Pharmaceutical Preparations; Population; Post-Traumatic Stress Disorders; Prevalence; Provider; psychosocial; Public Health; public health relevance; Puerto Rican; Questionnaires; Randomized; Randomized Controlled Trials; remediation; Reporting; Research; Research Design; Resources; Role; Savings; Self Management; service delivery; Services; Social Work; Social Workers; Stress; Symptoms; System; Testing; therapy development; treatment arm; Treatment Efficacy; trial comparing; Vacuum; ","The Asthma Action at Erie Trial","123797","CLHP","Community-Level Health Promotion Study Section ","","","05","472001","177582","649583",""
"9697433","R21","MH","5","N","04/22/2019","04/01/2019","03/31/2020","242","R21MH113882","","PA-16-161","5R21MH113882-02","NIMH:242360\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","SANTA MONICA","UNITED STATES","","33","006914071","US","6856101","RAND CORPORATION","CA","904013208","NARRATIVE This exploratory/developmental study applies social network analysis methods to Medicaid claims data to examine care for physical health conditions received by adults with serious mental illness (SMI). Provider networks will be characterized using standard network measures, such as network size and density, and used to develop new measures of the relationships between behavioral health and general medical care providers. These measures will provide researchers and policy makers with new tools for improving the care for adults with SMI.","1907930; ","BRESLAU, JOSHUA A;","RUPP, AGNES","05/15/2018","03/31/2020","Accident and Emergency department; Address; Adult; Affect; Age; base; Behavioral; behavioral health; beneficiary; care providers; care systems; Caring; Characteristics; Chronic; Clinic; Comorbidity; cost; Data; density; Development; Diagnosis; Effectiveness; Enrollment; Exploratory/Developmental Grant; Face; Foundations; Future; Geographic Locations; Goals; Health; Health Benefit; health care delivery; Health Care Sector; health care service utilization; Health Personnel; Health Services; Health system; Healthcare; Healthcare Systems; Home environment; Hospitals; improved; innovation; inpatient service; Insurance Claim Review; interest; Investigation; Life Expectancy; Link; Maps; Measurement; Measures; Medicaid; Medical; medical specialties; Mental disorders; Mentally Ill Persons; Methodology; Methods; Modeling; Nature; Network-based; Outcome; Pathway Analysis; Patients; Pattern; Patterns of Care; Performance; physical conditioning; Policies; Policy Maker; Population; primary care services; Primary Health Care; Provider; provider networks; Public Health; Publishing; Quality of Care; Reporting; Request for Proposals; Research; Research Personnel; Research Project Grants; Rural; severe mental illness; Social Network; Structure; Substance Use Disorder; System; Systems Integration; Testing; tool; Work; ","Provider Networks and Quality of Physical Health Care for Adults with Serious Mental Illness","113882","SERV","Mental Health Services Research Committee ","","","02","125000","117360","242360",""
"9700675","P41","EB","5","N","04/26/2019","03/01/2019","02/29/2020","","P41EB015922","","PAR-17-083","5P41EB015922-22","NIBIB:281569\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","Los Angeles","UNITED STATES","","34","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PROJECT NARRATIVE - TR&D3: INTRINSIC SURFACE MAPPING The novel surface mapping tools developed in this project will provide more accurate alignment of brain anatomy in cross-sectional and longitudinal studies. This will provide much enhanced power in the detection of anatomical and functional changes in neurological and other disorders.","10234518; ","SHI, YONGGANG ;","","","","Adolescent; Algorithms; Alzheimer's Disease; Anatomic Surface; Anatomy; Atrophic; base; Benchmarking; Biological; Brain; Brain imaging; Brain Mapping; Brain region; Categories; Cell Nucleus; Classification; Communities; computational anatomy; computer framework; Computer software; computerized tools; Cross-Sectional Studies; Custom; Data; Detection; Development; Disease; Evolution; Fiber; gray matter; high dimensionality; Human; Image; imaging study; improved; Isometric Exercise; Laboratories; Lead; Libraries; Location; Longitudinal Studies; Manuals; Maps; Methods; Multimodal Imaging; multimodality; Neuroanatomy; neuroimaging; Neurologic; Neurosciences; next generation; novel; novel strategies; Pattern; Performance; Play; Positioning Attribute; Process; reconstruction; Regression Analysis; Research; Research Personnel; Resources; Role; Series; shape analysis; Software Tools; Source Code; Statistical Data Interpretation; Structure; Surface; synergism; Techniques; tool; treatment effect; user friendly software; validation studies; web site; Work; ","TR&D3: Intrinsic Surface Mapping","015922","ZEB1","Special Emphasis Panel ","5230","","22","170648","110921","","281569"
"9702788","P30","DK","5","N","04/24/2019","04/01/2019","03/31/2020","847","P30DK057521","","RFA-DK-13-004","5P30DK057521-20","NIDDK:1469898\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","PUBLIC HEALTH RELEVANCE: This Diabetes Research center provides high quality, cutting edge and cost effective technical support to investigators performing research related to Diabetes Mellitus. It also provides seed grants for diabetes-related research, a resource that has been avidly sought by area investigators.","1911463; ","FLOREZ, JOSE CARLOS;","HYDE, JAMES F","06/01/2000","03/31/2020","Academic Medical Centers; Address; Area; Arts; Autoimmunity; base; Biology; Boston; Caring; Cellular biology; Chemicals; Clinical; Clinical Investigator; Collaborations; Communication; Communities; cost effective; Dana-Farber Cancer Institute; design; Development; Diabetes Mellitus; diabetic patient; Direct Costs; Endocrinology; energy balance; Ensure; Etiology; Eye; Flow Cytometry; Fostering; Gene Expression; General Hospitals; Genetic; Genomics; Goals; Graft Rejection; Grant; Hospitals; Human; Human Genetics; Image; Immunologics; Immunology; Institutes; Institution; Insulin Resistance; Insulin-Dependent Diabetes Mellitus; International; islet; Israel; Laboratories; Massachusetts; Medical center; medical schools; Metabolic; metabolomics; Methods; Molecular; Molecular Biology; Molecular Genetics; Molecular Immunology; Monitor; Morphology; Mus; New England; Non-Insulin-Dependent Diabetes Mellitus; optimal treatments; Pathogenesis; Physiology; Preparation; Production; programs; Proteomics; public health relevance; Public Health Schools; Regulation; repository; Research; Research Institute; Research Personnel; Resources; Schools; Science; Scientist; screening; Seeds; Services; Signal Transduction; small hairpin RNA; Structure of beta Cell of islet; Talents; Teaching Hospitals; Technology; Training; Transgenic Organisms; Translational Research; Update; Vascular System; web site; Woman; ","Boston Area Diabetes Endocrinology Research Center","057521","ZDK1","Special Emphasis Panel ","","","20","1093008","376890","1469898",""
"9710566","P30","AG","1","N","04/26/2019","04/01/2019","03/31/2020","","P30AG062422","","RFA-AG-19-001","1P30AG062422-01","NIA:517555\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","7605477; ","SEELEY, WILLIAM W;","","","","Age; Age of Onset; Anatomy; Autopsy; base; Basic Science; Biological; Biological Markers; biomarker discovery; Biomaterials Research; Brain; Brain Stem; Clinical; Collaborations; Communities; Complex; Consensus; Custom; Data; Databases; Dementia; design; Diagnosis; Diagnostic; Disease; DNA; Doctor of Philosophy; Educational process of instructing; Elements; Equipment and supply inventories; Event; Fibroblasts; Fostering; Freezing; Genetic; Goals; Heterogeneity; Human; Image; imaging approach; improved; innovation; International; Link; meetings; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; molecular imaging; Nerve Degeneration; Neurodegenerative Disorders; neuroimaging; neuroinflammation; Neurologist; neuropathology; Neurosciences; next generation; novel strategies; Paper; Participant; Pathogenicity; Pathologic; Pathology; Patients; Phenotype; prion-like; programs; Publishing; Research; Research Personnel; Research Support; Resources; Role; Sampling; Secure; Services; Ships; Specimen; Spinal Cord; Stains; success; symposium; Symptoms; tau Proteins; Time; tissue processing; Tissues; Training; Translational Research; Validation; Work; ","Core D: Neuropathology Core","062422","ZAG1","Special Emphasis Panel ","5036","","01","322632","194923","","517555"
"9710570","P30","AG","1","N","04/26/2019","04/01/2019","03/31/2020","","P30AG062422","","RFA-AG-19-001","1P30AG062422-01","NIA:125184\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","2049702; ","YAFFE, KRISTINE ;","","","","Aging; Alzheimer's Disease; Animal Model; Area; Award; base; Basic Science; behavioral neurology; Biological Markers; brain health; Capsicum; career; career development; Career Mobility; Caregiver well-being; Cell model; Clinical; Clinical and Translational Science Awards; clinical investigation; Clinical Trials; Collaborations; Communication; Dementia; Development; Diagnosis Clinical Trials; Discipline; Disease; education research; Educational Curriculum; Emotions; end of life; Enrollment; Ensure; Environment; Epidemiology; experience; Faculty; Fellowship; Fostering; Funding; Geriatric Psychiatry; Geriatrics; global health; Goals; Grant; health economics; Health Policy; Heterogeneity; Image; improved; Institutes; Institution; Internal Medicine; International; K-Series Research Career Programs; Knowledge; Leadership; leadership development; Learning; medical specialties; Medicine; Memory; Mental disorders; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Minority; Modeling; multidisciplinary; Nerve Degeneration; Neurology; Neuropsychology; next generation; novel strategies; outreach; Phenotype; Positioning Attribute; Program Development; programs; Psychiatry; Psychologist; Research; Research Methodology; Research Personnel; Research Training; Resources; Scientist; skill acquisition; skills; social health determinants; success; Talents; Training; Training Programs; translational scientist; United States National Institutes of Health; Work; Writing; ","Research Education Component","062422","ZAG1","Special Emphasis Panel ","5040","","01","115911","9273","","125184"
"9717989","F30","HL","5","N","04/22/2019","04/20/2019","04/19/2020","838","F30HL142201","","PA-16-305","5F30HL142201-02","NHLBI:37697\","TRAINING, INDIVIDUAL","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CINCINNATI","UNITED STATES","","01","071284913","US","615001","CINCINNATI CHILDRENS HOSP MED CTR","OH","452293039","Project Narrative The genetic basis of tracheal defects is poorly understood. This project aims to elucidate these using Gli mutant murine models to identify the mechanism by which HH signaling regulates tracheal development. The results of these experiments will inform the basis of tracheal defects in human patients, facilitating prenatal diagnosis and as well as guiding strategies to generate therapeutically useful tracheal tissue from iPSCs.","11972618; ","NASR, TALIA S;","KALANTARI, ROYA","04/20/2018","04/19/2022","Address; base; Bioinformatics; Biological Process; Cadherins; Cartilage; cartilage development; Cell Adhesion; Cells; Cellular biology; Childhood; Chondrogenesis; clinical Diagnosis; Clinical Treatment; Data; data mining; Data Set; Defect; Development; Diagnosis; Disease; Embryo; Epithelial; Equilibrium; Erinaceidae; Esophagus; Etiology; Exhibits; exome sequencing; experimental study; Extracellular Matrix; Failure; fetal; Fetal Development; FOXF1 gene; Gene Expression Profiling; Gene Targeting; Genes; Genetic; Genetic Predisposition to Disease; Genomics; GLI3 gene; Goals; Human; human tissue; Impairment; In Situ; In Situ Hybridization; In Vitro; induced pluripotent stem cell; Lead; Learning; Lesion; Literature; loss of function; Mediating; Mesenchymal; Mesenchymal Differentiation; Mesenchyme; Metalloproteases; Modeling; Molecular; Morphogenesis; mouse model; Mus; mutant; Mutation; novel therapeutics; Online Mendelian Inheritance In Man; overexpression; Pallister-Hall syndrome; Pathway interactions; Patients; Perinatal; Physicians; Prenatal Diagnosis; Primitive foregut structure; Process; programs; Proteins; Publishing; Research; respiratory; Review Literature; Scientist; Series; Signal Transduction; Smooth Muscle; Smooth Muscle Myocytes; smoothened signaling pathway; Testing; Therapeutic; Tissues; Trachea; Tracheal Atresia; Tracheoesophageal Fistula; Training; transcription factor; transcriptome sequencing; Transgenic Organisms; treatment strategy; Tube; virtual; WNT Signaling Pathway; Xenopus; ","Identifying Gli-Regulated Targets during Tracheal Development and Disease","142201","ZRG1","Special Emphasis Panel ","","","02","37697","","37697",""
"9729347","U19","AI","2","N","04/22/2019","04/23/2019","03/31/2020","855","U19AI110818","","RFA-AI-18-004","2U19AI110818-06","NIAID:4400000\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","","07","623544785","US","10021177","BROAD INSTITUTE, INC.","MA","021421027","Our limited knowledge of the individual organisms responsible for infectious diseases, and the way they interact with the hosts they infect, and the insects that transmit them, prevents us from better managing the staggering global burden of these diseases. We will focus on defining the genes and genomes of these organisms, and how these genes influence disease and drug resistance. We will use collaborative approaches and powerful new laboratory and analytical techniques to study diseases caused by viruses, bacteria, fungi and parasites to develop new ways to diagnose, prevent and treat them.","1922265 (contact); 9621853; ","BIRREN, BRUCE W. (contact); NEAFSEY, DANIEL E;","LEE, EUN MI","04/10/2014","03/31/2024","Address; analytical method; Antibiotic Resistance; Antigen Presentation; Arthropod Vectors; Bacteria; base; Bioinformatics; Biological Assay; Biological Models; Biology; burden of illness; Cells; collaborative approach; combat; Communicable Diseases; Communities; Computational Biology; Cryptococcus; Culicidae; Data; Diagnosis; Dimensions; Disease; Disease Resistance; Disease Vectors; Disseminated candidiasis; Drug resistance; Enterococcus; experience; Fatal Outcome; Fungal Drug Resistance; fungus; Genes; Genome; genome wide association study; Genomic approach; genomic data; genomic epidemiology; Genomics; Human; I-antigen; Immune response; Immunity; improved; Individual; Industrialization; Infection; Infectious Diseases Research; innovation; Insect Vectors; Insecta; Intervention; Knowledge; Laboratories; Lead; Liver; Malaria; Measures; Mediating; Metagenomics; Methodology; microbial; Organism; pan-genome; Parasites; Parasitic Diseases; pathogen; Pathogenesis; Pharmaceutical Preparations; Population; Practice Management; pressure; prevent; priority pathogen; Process; program dissemination; Public Health; Recording of previous events; Recurrence; Research; Research Personnel; Research Project Grants; resistance gene; ribosome profiling; Rodent; Sampling; Scientist; single-cell RNA sequencing; Structure; synergism; System; Talaromyces; Techniques; Technology; technology development; Testing; Tissues; tool; transcriptome sequencing; transcriptomics; transmission process; Urinary tract infection; Uropathogenic E. coli; Variant; vector; vector mosquito; Viral; Viral Antigens; Viral Hemorrhagic Fevers; Virulence; Virus; Work; ","Advancing Genomic Technologies to Combat Infectious Disease: Mapping Dynamics within Single Cells, Individual Hosts, and Global Populations","110818","ZAI1","Special Emphasis Panel ","","","06","2860674","1539326","4400000",""
"9732024","R15","MH","1","N","04/23/2019","04/23/2019","04/22/2022","242","R15MH119626","SCHOOLS OF ARTS AND SCIENCES","PA-18-343","1R15MH119626-01","NIMH:462000\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","FLUSHING","UNITED STATES","PSYCHOLOGY","10","619346146","US","1605021","QUEENS COLLEGE","NY","100367207","Computerized cognitive training (CCT) is a promising new treatment option for depression. This study proposes to test its mechanism of action by demonstrating change in cognitive functioning, depressed mood, everyday functioning, and brain activity using fMRI following 8 weeks of CCT. The successful demonstration of its mechanism of action will provide an additional treatment option to help reduce the deleterious impact of depression in young adults, improve quality of life, and diminish healthcare costs.","7384345; ","SNEED, JOEL R.;","MORRIS, SARAH E","04/23/2019","04/22/2022","active control; Address; Adult; Affect; Age; aged; aging population; Anterior; Area; base; Behavioral; Behavioral Sciences; Brain; Car Phone; career; cingulate cortex; Cities; Clinical; Clinical assessments; Clinical Research; Code; Cognition; Cognitive; cognitive control; cognitive function; cognitive training; college; computerized; Depressed mood; depressed patient; depressive symptoms; Diffuse; disability; Disadvantaged; Emotional; executive function; Failure; follow-up; Functional Magnetic Resonance Imaging; Goals; graduate student; Health Care Costs; improved; Major Depressive Disorder; Measures; Mental Depression; Meta-Analysis; Methodology; mobile computing; mood regulation; Moods; neural network; neuroimaging; Neuronal Plasticity; Neuropsychology; New York; Outcome; Participant; Patients; Pattern; Performance; Populations at Risk; Positioning Attribute; Prefrontal Cortex; processing speed; programs; Psychology; Quality of life; Randomized; recruit; Research; Research Proposals; Research Training; Rest; Students; Testing; Training; undergraduate student; Universities; Waiting Lists; Work; young adult; ","Testing the mechanism of action of computerized cognitive training in young adults with depression:Clinical, cognitive and neuroimaging outcomes","119626","APDA","Adult Psychopathology and Disorders of Aging Study Section ","","","01","300000","162000","462000",""
"9737397","R01","CA","2","N","04/23/2019","04/23/2019","03/31/2020","393","R01CA181047","SCHOOLS OF MEDICINE","PAR-18-559","2R01CA181047-06","NCI:319410\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","KANSAS CITY","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","03","016060860","US","1484303","UNIVERSITY OF KANSAS MEDICAL CENTER","KS","661608500","PROJECT NARRATIVE The key contributions of this study are to determine whether a comprehensive women?s health literacy intervention is effective at changing intersecting behaviors among women leaving jail; whether an electronic women?s health literacy intervention is feasible and effective; and how much human ?touch? is ideal in an electronic intervention. Knowledge gained from this study will help develop a new paradigm for mitigating health disparities among vulnerable women.","9133472; ","RAMASWAMY, MEGHA ;","CHOU, WEN-YING","04/23/2014","03/31/2024","Address; Age; arm; base; Behavior; behavior change; Belief; birth control; Breast Cancer Detection; cancer health disparity; cancer risk; Car Phone; Cervical; cervical cancer prevention; Cervical Cancer Screening; Color; Communications Media; Communities; Discharge Plannings; Drug usage; Effectiveness; Electronic Mail; Evidence based intervention; experience; Face; Facebook; falls; Fibrinogen; follow-up; General Population; Health; Health behavior; health disparity; Health education; Health Educators; health empowerment; health literacy; Health Promotion; high risk population; Human; Imprisonment; improved; Internet; Intervention; Interview; Jail; Justice; Knowledge; Lead; Left; literacy; Literacy Programs; malignant breast neoplasm; Malignant neoplasm of cervix uteri; Malignant Neoplasms; Mental Health; Modality; Modeling; Modification; Multimedia; Nature; Outcome; Pamphlets; Participant; Perception; post intervention; pregnant; Prevention; Prevention program; Preventive; Prisons; Productivity; Publications; Randomized; Randomized Controlled Trials; Recording of previous events; recruit; Research; Risk; Risk Factors; Risk Reduction; Role; screening; Screening for cancer; Self Efficacy; Sexual Health; Sexually Transmitted Diseases; social media; standard of care; STI prevention; Surveys; Testing; Text; Text Messaging; Time; Touch sensation; Trauma; unintended pregnancy; uptake; Vulnerable Populations; Woman; Women's Health; Work; ","Sexual  Health  Empowerment  for  Jail-Involved  Women's  Health  Literacy  and  Prevention","181047","HDEP","Health Disparities and Equity Promotion Study Section ","","","06","208765","110645","319410",""
"9753631","R21","TW","1","N","04/25/2019","04/15/2019","02/29/2020","989","R21TW011260","","PAR-18-732","1R21TW011260-01","FIC:196434\","Non-SBIR/STTR RPGs","2019","FOGARTY INTERNATIONAL CENTER","","PHILADELPHIA","UNITED STATES","","02","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","NARRATIVE: HIV stigma is having adverse effects on HIV prevention, treatment engagement, adherence to antiretroviral therapy (ART) as well as health outcomes, viral load, depression, suicidality, quality of life, in adolescents living with HIV. The proposed research will address a significant gap in scientific knowledge: the lack of efficacious strategies to reduce HIV stigma and its negative consequences on adolescents. This research will culminate in an intervention whose efficacy can be evaluated in a subsequent randomized controlled trial.","8816028; 1898179 (contact); ","CHILISA, BAGELE M; JEMMOTT, JOHN BARTON (contact);","BANSAL, GEETHA PARTHASARATHY","04/15/2019","02/28/2021","17 year old; Address; Adherence; Adolescent; adolescent health; Adverse effects; Affect; African; Age; AIDS prevention; Alcohol or Other Drugs use; antiretroviral therapy; Applications Grants; base; behavior change; Botswana; Caregivers; Caring; Child; Clinical; Communities; Conflict (Psychology); Consequences of HIV; Consult; Counseling; Country; Data Collection; Depression and Suicide; Development; Discrimination; Divorce; Drops; Educational workshop; Ensure; experience; Focus Groups; Fright; Goals; Health; High Prevalence; HIV; HIV risk; Household; Husband; Impairment; improved; Intervention; Intervention Studies; Knowledge; Learning; Malawi; member; Mental Depression; multidisciplinary; Outcome; Parents; peer; Pennsylvania; Pharmaceutical Preparations; Population; Preparation; Prevalence; Prevention; Probability; programs; Quality of life; Randomized Controlled Trials; Recording of previous events; recruit; Research; Research Methodology; Research Personnel; Risk; Risk Reduction; rural area; rural setting; Safe Sex; Science; self esteem; Series; Sexual Partners; Side; social cognitive theory; social stigma; South Africa; Suicide; Surveys; Tanzania; Teenagers; Testing; Thailand; theories; therapy adherence; transmission process; Treatment Efficacy; Uganda; United States; Universities; urban area; urban setting; Vertical Disease Transmission; Viral Load result; willingness; Work; Zimbabwe; ","Reducing Stigma to Improve HIV/AIDS Prevention, Treatment, and Care among Adolescents Living with HIV in Botswana","011260","ZRG1","Special Emphasis Panel ","","","01","129700","66734","196434",""
"9758543","F30","CA","1","N","03/28/2019","04/01/2019","03/31/2020","398","F30CA239441","SCHOOLS OF MEDICINE","PA-18-673","1F30CA239441-01","NCI:32316\","TRAINING, INDIVIDUAL","2019","NATIONAL CANCER INSTITUTE","","WASHINGTON","UNITED STATES","INTERNAL MEDICINE/MEDICINE","98","049515844","US","2869001","GEORGETOWN UNIVERSITY","DC","200570001","PROJECT NARRATIVE Immunotherapy has been largely unsuccessful in pancreatic cancer, in part because of the thick scar tissue that often surrounds the tumor. This project aims to better understand the relationship between components of this scar tissue and anti-cancer immune cells. Successful completion of this project will fill current gaps in scientific knowledge and potentially identify new immunotherapies that would prolong life for pancreatic cancer patients.","15547201; ","O'CONNELL, ALLISON ;","KORCZAK, JEANNETTE F","04/01/2019","03/31/2024","Activated Natural Killer Cell; angiogenesis; anti-cancer; anti-PD1 therapy; anti-tumor immune response; antitumor effect; Attenuated; base; Biological; Biology; Cancer Patient; Cell Communication; Cell Line; Cell Surface Receptors; cell type; Cells; Characteristics; chemotherapy; Cicatrix; Clinical; clinical application; Clinical Trials; clinically relevant; Coculture Techniques; cytokine; cytotoxicity; Data; Desmoplastic; Dipeptidyl Peptidases; Disease; Endopeptidases; Exposure to; Extracellular Matrix; Failure; fibroblast activation protein alpha; fibroblast-activating factor; Fibrosis; Flow Cytometry; Goals; Human; human data; imaging system; Immune; Immune Checkpoint; immune clearance; Immune response; immunogenic; Immunosuppression; Immunosuppressive Agents; Immunotherapy; improved; In Vitro; in vitro activity; in vivo; Infiltration; Knock-out; Knowledge; Lesion; Life; liquid crystal polymer; live cell imaging; Malignant neoplasm of pancreas; Malignant Neoplasms; Mediating; migration; Modeling; Monitor; mouse model; Mus; nano-string; Natural Killer Cells; NK Cell Activation; novel; novel strategies; Outcome; overexpression; Pancreas; Pancreatic Ductal Adenocarcinoma; pancreatic neoplasm; pathology imaging; Pattern; Pharmacology; Phenotype; Population; protein activation; protein biomarkers; protein expression; protein function; Protein Inhibition; Public Domains; Radiation therapy; Receptor Cell; response; Role; Sampling; Serine Protease; Signaling Molecule; stellate cell; Survival Rate; System; Testing; therapeutic target; Thick; Time; Tissues; tool; tumor; tumor growth; Tumor Immunity; Work; ","The Potential Role of Firboblast Activation Protein as a Natural Killer Cell Immune Checkpoint in Pancreatic Cancer","239441","ZRG1","Special Emphasis Panel ","","","01","32316","","32316",""
"9761183","F31","DK","1","N","02/26/2019","03/01/2019","02/29/2020","847","F31DK120275","SCHOOLS OF MEDICINE","PA-18-671","1F31DK120275-01A1","NIDDK:45016\","TRAINING, INDIVIDUAL","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","MADISON","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","Project Narrative Diabetes mellitus is an unsolved clinical problem with ever-increasing prevalence in the global population. A mechanism-based therapeutic approach to diabetes prevention is necessary to address this epidemic. Identifying drug targets that can specifically promote pancreatic ?-cell survival safely and effectively will add an important new approach to the current diabetes therapies. By identifying direct roles and mechanisms by which cholecystokinin (CCK) signaling promotes ?-cell survival, the completion of the aims in this proposal will open new avenues of investigation for the development of therapies that can selectively agonize the CCK receptors to safely and efficiently improve ?-cell mass and function.","14271679; ","KIM, HUNG TAE ;","CASTLE, ARTHUR","03/01/2019","02/28/2022","Address; Adverse effects; Agonist; Americas; Apoptosis; Apoptotic; Attenuated; Automobile Driving; B Cell Proliferation; base; Beta Cell; Biology; career; career development; CCKBR gene; Cell Death; Cell physiology; Cell Survival; cell type; Cells; Cholecystokinin; Cholecystokinin Receptor; Clinical; clinically relevant; Complications of Diabetes Mellitus; Coupled; CREB1 gene; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; cytokine; Development; Diabetes Mellitus; diabetes mellitus therapy; Diabetes prevention; diabetic; Diabetic mouse; diabetogenic; Disease model; Drug Targeting; Ensure; Epidemic; epidemiology study; Exocrine pancreas; experience; Exposure to; Failure; Financial cost; functional decline; G-Protein-Coupled Receptors; gastrointestinal system; Goals; graduate student; Growth; GTP-Binding Proteins; Healthcare; Hormones; Human; improved; In Vitro; in vivo; Insulin; Insulin Resistance; Investigation; islet; Islets of Langerhans; Mammalian Cell; Mediating; Molecular; mortality; Mus; Neuraxis; Non-Insulin-Dependent Diabetes Mellitus; novel strategies; Obese Mice; Obesity; Outcome; overexpression; Pancreas; Pathogenesis; Pathway interactions; Patients; Peptides; Pharmaceutical Preparations; Pharmacology; Population; Prediabetes syndrome; Prevalence; prevent; Production; professor; protective effect; receptor; Receptor Activation; receptor expression; Receptor Signaling; Research; Role; Science; Signal Pathway; Signal Transduction; Societies; Stress; stressor; Structure of beta Cell of islet; Testing; Therapeutic; Therapeutic Agents; therapeutic target; therapy development; Tissues; Training; Translations; Transplantation; ","Selective cholecystokinin receptor signaling in the pancreatic islet as therapeutic target against diabetogenic stress","120275","ZDK1","Special Emphasis Panel ","","A1","01","45016","","45016",""
"9767234","R01","HD","5","N","04/22/2019","04/01/2019","03/31/2020","865","R01HD083314","","PA-13-302","5R01HD083314-04","NICHD:321217\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","CHICAGO","UNITED STATES","","07","068477546","US","6898901","REHABILITATION INSTITUTE OF CHICAGO","IL","606113167","PUBLIC HEALTH RELEVANCE: The goal of this proposed research is to explore motor adaptation to a mediolateral force applied at the pelvis during walking in humans with spinal cord injury (SCI) and test whether pelvis perturbation training paired with transcutaneous spinal direct current stimulation (tsDCS) will be effective in improving dynamic balance and locomotor function in humans with SCI. The results obtained from this study will lead to an innovative clinical therapy aimed at improving balance and walking function in humans with SCI. We expect that pelvis perturbation training paired with tsDCS will substantially improve dynamic balance and locomotor function in humans with SCI.","8290130; ","WU, MING ;","MARDEN, SUSAN F","06/10/2016","03/31/2021","Activities of Daily Living; Affect; Anodes; Balance training; base; Cathodes; Clinical; Communities; Depressed mood; Elderly; equilibration disorder; Equilibrium; experience; Exposure to; falls; functional gain; Gait; Goals; hamstring; Human; improved; Incidence; Individual; innovation; kinematics; Knowledge; Lateral; Length; Locomotion; Lower Extremity; Medial; Motor; Muscle; Muscle Contraction; neural circuit; Neural Pathways; Neuronal Plasticity; Pathway interactions; patient population; Patients; Pattern; Pelvis; Placebos; Play; Population; post stroke; Posture; public health relevance; Quality of life; Rehabilitation therapy; relating to nervous system; Research; response; Role; Signal Transduction; Spinal; Spinal Cord; Spinal cord injury; Spinal cord injury patients; Spinal Cord Lesions; Synapses; Testing; Training; treadmill; treadmill training; Walking; Width; ","Improve dynamic lateral balance of humans with SCI","083314","MFSR","Motor Function, Speech and Rehabilitation Study Section ","","","04","212975","108242","321217",""
"9775384","R44","DK","2","N","04/22/2019","04/22/2019","03/31/2020","847","R44DK109779","","PAR-18-108","2R44DK109779-04A1","NIDDK:999958\","SBIR-STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","EMERALD HILLS","UNITED STATES","","18","078761782","US","10036645","SONOMOTION, INC.","CA","940624040","One in 11 Americans will have urinary stones in their lifetime. Most of the $10B annual cost of this disease is incurred by visits to the emergency department, surgery, and unplanned post- surgery events. This project aims to conduct a feasibility first-in-human clinical trial of Break Wave, a promising new office-based and anesthesia-free method to fragment stones that could reduce complications and costs associated with current stone management","9871058; ","LEVY, OREN ;","GOSSETT, DANIEL ROBERT","05/01/2016","03/31/2022","Accident and Emergency department; Acute; Address; Adverse event; Affect; Aftercare; American; Americas; Anesthesia procedures; Animals; arm; base; care burden; Chronic; Clinic; Clinical; Clinical Trials; Consensus; cost; Cost of Illness; Data; design; Device Designs; Devices; Diabetes Mellitus; Disease; Dose; Effectiveness; Elements; Emergency Department Physician; Emergency department visit; Ensure; Event; Extracorporeal Shockwave Lithotripsy; Family suidae; Feasibility Studies; feasibility trial; Feedback; first-in-human; Fracture; Frequencies; Goals; Grant; Healthcare; Histologic; Human; human subject; Hypertension; Image; imaging system; improved; In Vitro; in vivo; Injury; Intervention; Kidney; Kidney Calculi; Laser Lithotripsy; Lithotripsy; low-dose spiral CT; Methods; Modeling; Modification; Movement; Natural graphite; novel; Obesity; open label; Operative Surgical Procedures; Outcome; Patients; Performance; Physiologic pulse; Population; preclinical safety; preclinical study; preclinical trial; pressure; Prevalence; Procedures; prospective; Protocols documentation; recruit; Risk; Safety; Shock; simulation; standard of care; System; Techniques; Technology; Testing; Time; Ultrasonography; Update; Ureteroscopy; Urinary Calculi; Urologic Diseases; Urologist; Urology; verification and validation; Visit; Width; X-Ray Computed Tomography; ","First-In-Human Feasibility Trial of Break Wave - The Office-Based Lithotripsy Solution","109779","ZDK1","Special Emphasis Panel ","","A1","04","","","999958",""
"9795344","K23","HL","7","N","04/22/2019","04/24/2019","07/31/2019","838","K23HL138165","SCHOOLS OF MEDICINE","PA-18-590","7K23HL138165-03","NHLBI:130462\","OTHER RESEARCH-RELATED","2018","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CHICAGO","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","068610245","US","6644301","RUSH UNIVERSITY MEDICAL CENTER","IL","606123833","PROJECT NARRATIVE  Although individuals diagnosed with COPD have high rates of nicotine dependence, depression, and anxiety, there is very limited understanding of the psychological risk factors that commonly drive these conditions and how they can be addressed through targeted treatment. The proposed research will develop and test a novel smoking cessation intervention among COPD patients and use qualitative data from patients and providers to guide treatment delivery. Results are expected to provide needed information on a behavioral treatment with far-reaching implications for improving behavioral health and reducing morbidity and mortality among COPD patients.","11366629; ","MATHEW, AMANDA R;","TIGNO, XENIA","11/01/2018","07/31/2022","","Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients","138165","MPOR","NHLBI Mentored Patient-Oriented Research Review Committee ","","","03","120798","9664","130462",""
"9828485","R01","EB","7","N","04/24/2019","04/24/2019","11/30/2019","286","R01EB023052","","PA-18-590","7R01EB023052-02","NIBIB:637397\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","Contact PD/PI: Annabi, Nasim Project Narrative Despite recent advances in the development of surgical materials, there are no clinically approved surgical adhesives/sealants that are flexible and nontoxic, bind strongly to tissues, and work well within the wet and highly dynamic body environments, in the presence of certain body fluids. In this proposal, we aim to engineer a novel light-activated, and highly adhesive surgical sealant from a naturally derived polymer, which can provide flexibility without compromising strength and can adhere strongly to the native tissues to stop air/body fluid leakages after surgical procedures. Project Narrative Page 8","12292974 (contact); 10668534; 8527169; ","ANNABI, NASIM  (contact); GANGADHARAN, SIDHARTA ; KHADEMHOSSEINI, ALI ;","RAMPULLA, DAVID","12/01/2018","11/30/2021","Address; Adhesions; Adhesives; Air; Anastomosis - action; Animal Model; base; Binding; Biocompatible Materials; biomaterial compatibility; Biopolymers; Blood Vessels; Body Fluids; Cardiovascular Surgical Procedures; Catechols; Characteristics; chemical bond; Chemicals; Clinic; Clinical; cost; crosslink; Cyanoacrylates; Data; Defect; design; Development; Devices; Engineering; Environment; Exhibits; Extravasation; Family suidae; Fibrin Tissue Adhesive; flexibility; Formulation; Gelatin; Goals; Hydrogels; implantation; improved; In Vitro; in vivo; in vivo evaluation; Infection; injured; Ischemia; Light; Liquid substance; Liver; Lung; mechanical properties; Mechanics; Methods; minimally invasive; Modeling; Movement; Mussels; novel; Operative Surgical Procedures; Outcome; physical property; Pleural; Polymers; Postoperative Period; pressure; prevent; Procedures; Property; Punch Biopsy; Rattus; repaired; seal; Site; skills; soft tissue; Solid; Structure; Structure of parenchyma of lung; subcutaneous; Surface; Surgeon; surgery material; Surgical complication; Surgical Mesh; Surgical sutures; Testing; Thoracic Surgical Procedures; Time; Tissues; Toxic effect; Visible Radiation; Work; wound; wound closure; ","Engineering a naturally derived and highly adhesive surgical sealant","023052","BMBI","Biomaterials and Biointerfaces Study Section ","","","02","419110","218287","637397",""
"9856837","R43","AI","3","N","04/18/2019","04/25/2019","12/31/2019","855","R43AI136573","","PA-19-029","3R43AI136573-01S1","NIAID:55000\","SBIR-STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LANCASTER","UNITED STATES","","16","080388725","US","10043148","FREEFLOW MEDICAL DEVICES, LLC","PA","176015927","Narrative: FreeFlow Medical Devices is using an inert surface chemistry to prevent the formation of biofilms and thrombosis on medical devices implanted in the body. Significant in- vitro and animal testing has supported the efficacy of this coating in catheters over 90 days in biological flow. Top hospitals (Boston Children?s Hospital) and major medical device companies (Bard Access/BD) are supporting the development of this technology.","15190978; ","BANDYOPADHYAY, SAIBAL ;","ERNST, NANCY L","01/15/2018","12/31/2019","Adhesions; Age; Animal Testing; Bacteria; Biological; biomaterial compatibility; Blood; Blood coagulation; Blood Platelets; Blood Substitutes; Boston; Caring; Catheters; Chemistry; commercialization; Complex; Dangerousness; Devices; Diagnosis; Feedback; Fibrin; Fluorocarbons; fungus; Goals; Gram-Negative Bacteria; Health Professional; Healthcare; Healthcare Systems; Hospitals; Immobilization; implantable device; improved; improved outcome; In Vitro; Infection; Intravenous; Liquid substance; Liquid Ventilation; Location; Medical; Medical Device; Methods; Microbial Biofilms; mortality; novel; Operative Surgical Procedures; pathogen; Patient-Focused Outcomes; Patients; Pediatric Hospitals; Peripheral; Phase; Population; prevent; Prevention; Public Health; Research; Risk; Scientist; Sepsis; Surface; Technology; technology development; Thinness; Thrombosis; Thrombus; tool; Venous; Work; ","Omniphobic Coating to Prevent Central Line Catheter Infections","136573","","","","S1","01","","","55000",""
"9879130","R00","MH","4","N","04/26/2019","04/01/2019","01/31/2020","242","R00MH110665","SCHOOLS OF MEDICINE","PA-16-193","4R00MH110665-03","NIMH:248999\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","EAST LANSING","UNITED STATES","PEDIATRICS","08","193247145","US","5245901","MICHIGAN STATE UNIVERSITY","MI","488242600","Project Narrative Neurodevelopmental disorders such as autism and intellectual disability are prevalent, yet our understanding of the origins of these disorders is largely incomplete. Scientific progress has identified many candidate genes thought to be involved in brain development and the disorders thereof. The relevance of this research to public health is to understand the normal role of one these candidate genes, KitR, in brain development.","10750259; ","WILLIAMS, MICHAEL ROLAND;","PANCHISION, DAVID M","04/01/2019","01/31/2022","Address; autism spectrum disorder; Autistic Disorder; Biological Assay; Biological Models; Brain; Candidate Disease Gene; cell motility; Cells; Cerebellar cortex structure; Cerebellum; Cerebrum; Chemotactic Factors; Childhood; Complement; Corpus striatum structure; Data; Development; Disease; Ectopic Expression; Electrophysiology (science); Etiology; Experimental Designs; Experimental Genetics; Expression Profiling; frontal lobe; Goals; Human; Impairment; in vivo; Institution; Intellectual functioning disability; Interneurons; Knock-out; Knowledge; Ligands; Mental disorders; Michigan; Microscopy; migration; Modeling; Molecular; Morphology; Mus; mutant; Mutate; Mutation; Mutation Analysis; National Institute of Mental Health; Nature; nerve supply; Neural Crest; neurodevelopment; Neurodevelopmental Disorder; Neurologic; neuron development; Neurons; novel; patch clamp; Pathway interactions; Patients; Pattern; Phase; Phosphorylation; Population; Positioning Attribute; postnatal; postsynaptic; presynaptic; professor; Public Health; Purkinje Cells; receptor function; Receptor Protein-Tyrosine Kinases; reconstitution; reconstruction; relating to nervous system; repetitive behavior; Research; Research Priority; Role; Signal Transduction; social cognition; Stem Cell Factor; Structure of molecular layer of cerebellar cortex; symptomatology; Synapses; synaptogenesis; System; tenure track; Testing; Tissues; Training; Transgenic Organisms; Tyrosine; Universities; Viral; ","The Role of Kit Signaling in Cerebellar Development","110665","NSS","Special Emphasis Panel ","","","03","186839","62160","248999",""
"9890872","R01","CA","7","N","04/23/2019","01/01/2019","07/31/2019","393","R01CA220123","SCHOOLS OF MEDICINE","PA-18-590","7R01CA220123-13","NCI:268705\","Non-SBIR/STTR RPGs","2018","NATIONAL CANCER INSTITUTE","","SAN ANTONIO","UNITED STATES","BIOCHEMISTRY","21","800772162","US","578418","UNIVERSITY OF TEXAS HLTH SCIENCE CENTER","TX","782293901","PROJECT NARRATIVE Failure to repair damaged chromosomes compromises the integrity of the genome and can lead to cancer. The proposed studies will delineate the role of several tumor suppressors in the recombinational repair of chromosomes that harbor double-strand breaks and other deleterious lesions induced by ionizing radiation and chemical agents. The results will make a major contribution toward delineating the mechanism of homologous recombination in human cells and will help elucidate the role of DNA repair in radiation biology and cancer avoidance. !","1879397; ","SUNG, PATRICK ;","PELROY, RICHARD","01/01/2019","07/31/2022","","Genome Maintenance via the BRCA-PALB2 Tumor Suppressor Network","220123","CE","Cancer Etiology Study Section ","","","13","176200","92505","268705",""
"9914612","UG1","DA","3","N","04/23/2019","02/15/2019","05/31/2019","279","UG1DA013035","SCHOOLS OF MEDICINE","RFA-DA-15-008","3UG1DA013035-17S9","NIDA:207676\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","NEW YORK","UNITED STATES","PSYCHIATRY","12","121911077","US","5998304","NEW YORK UNIVERSITY SCHOOL OF MEDICINE","NY","10016","PUBLIC HEALTH RELEVANCE:  Addictions, including nicotine, drugs and alcohol, represent a major public health problem. Research is needed to translate new basic and therapeutic advances into effective and accessible treatment in our communities. The NIDA Clinical Trials Network and the Greater New York Node seek to fill this gap by engaging researchers, healthcare providers from primary care to specialty care, and policy-makers in research to improve addictions treatment nationally using science as the vehicle.","8192463; 2414926 (contact); ","NUNES, EDWARD V.; ROTROSEN, JOHN P (contact);","DOBBINS, RONALD","01/10/2001","05/31/2020","Academia; addiction; Address; Adolescent; Adopted; Adoption; Alcoholism; Alcohols; Area; base; Behavior Therapy; behavioral health; Budgets; care coordination; care outcomes; care providers; Caribbean region; Caring; Charge; Cities; Clinical; Clinical Management; Clinical Trials; Clinical Trials Network; Collaborations; college; Communities; comparative effectiveness; cost; Criminal Justice; Data; Development; Disease; disorder prevention; Early Intervention; eHealth; Electronic Health Record; epidemiology study; experience; Fostering; Freedom; Funding; Future; Gender Issues; Genetic; Genetic Research; Goals; Health; health care service organization; health care settings; health information technology; health management; Health Personnel; Health Services; Health Services Research; Health system; Healthcare Systems; Hepatitis C virus; HIV; HIV/HCV; Hospitals; improved; improved outcome; Individual; Infection; Infrastructure; innovation; Institution; Leadership; Learning; Long Island; Mainstreaming; Medical; Medical Informatics; medical schools; medical specialties; Medical Technology; Medicine; Mental disorders; Mental Health; Mentorship; Methodology; Methods; metropolitan; mHealth; National Institute of Drug Abuse; neuroimaging; Neurosciences; Neurosciences Research; New York; next generation; Nicotine; Patients; Pediatrics; performance site; Pharmaceutical Preparations; Pharmacotherapy; Phase; Policy Maker; Population; pragmatic trial; Prevention; Primary Health Care; Private Hospitals; programs; Provider; Public Health; public health relevance; Public Hospitals; Registries; Research; Research Personnel; Research Training; Resources; Risk Reduction; Science; screening; Services; Smoking; Substance abuse problem; Substance Use Disorder; System; Technology Transfer; Testing; Therapeutic; Training; Translating; treatment program; treatment services; treatment strategy; Universities; vaccine development; Vision; ","NIDA Clinical Trials Network: Greater New York Node","013035","ZDA1","Special Emphasis Panel ","","S9","17","136834","70842","207676",""
"9916061","R21","HD","7","N","04/26/2019","01/01/2019","04/30/2020","865","R21HD091916","SCHOOLS OF MEDICINE","PA-16-161","7R21HD091916-03","NICHD:199375\","Non-SBIR/STTR RPGs","2018","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","WASHINGTON","UNITED STATES","BIOCHEMISTRY","98","043990498","US","2863301","GEORGE WASHINGTON UNIVERSITY","DC","200520042","NARRATIVE  Our studies will offer mechanistic insight into a newly discovered dual functional switch that controls multiple ERb functions in reproductive biology. In addition, the proposed work will provide druggable targets for fine-tuning ERb activities in reproduction-related pathologies. Thus, the novel hypothesis and powerful technical tools promise both conceptual and technical advances in the field of reproductive biology.","8248747; 2093296 (contact); ","HU, YANFEN ; LI, RONG  (contact);","EISENBERG, ESTHER","08/01/2017","04/30/2020","","A Dual Functional Switch in Reproductive Biology","091916","ICER","Integrative and Clinical Endocrinology and Reproduction Study Section ","","","03","125000","74375","199375",""
"9916202","UG1","DA","3","N","04/23/2019","02/01/2019","05/31/2019","279","UG1DA015831","","RFA-DA-15-008","3UG1DA015831-17S6","NIDA:71784\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","BELMONT","UNITED STATES","","05","046514535","US","1876801","MCLEAN HOSPITAL","MA","024781064","PUBLIC HEALTH RELEVANCE:  The National Drug Abuse Treatment Clinical Trials Network (CTN) conducts clinically relevant drug abuse research in real-world settings, with an increasing emphasis on conducting studies in general medical settings. The New England Consortium Node of the CTN is poised to foster the development of effective, scalable, and sustainable interventions for individuals with a variety of substance use problems, so that they can be offered effective treatment in whatever healthcare setting they enter, thus improving overall public health.","1883776; 1869395 (contact); ","CARROLL, KATHLEEN M.; WEISS, ROGER D. (contact);","DOBBINS, RONALD","09/30/2002","05/31/2020","Accident and Emergency department; addiction; Address; Adolescent; Adult; Alcohol or Other Drugs use; Alcohols; Area; base; Boston; Buprenorphine; Caring; Child Care; chronic pain patient; cigarette smoke; Clinical; clinical infrastructure; clinical practice; Clinical Research; clinical research site; Clinical Treatment; Clinical Trials Network; clinically relevant; Cognitive Therapy; Communities; Computers; Connecticut; cost efficient; Data; Development; Diabetes Mellitus; Discipline of obstetrics; Doctor of Medicine; Doctor of Philosophy; Drug abuse; Drug usage; effective therapy; Effectiveness; efficacy research; efficacy trial; Electronic Health Record; Emergency Care; Face; financial incentive; Fostering; Funding; Goals; health care delivery; Health care facility; health care settings; health information technology; Health system; Healthcare; Healthcare Systems; high risk men; HIV; Hospital Departments; Hospitalization; Hospitals; improved; improved outcome; Individual; innovation; innovative technologies; Intervention; Intervention Studies; Leadership; Medical; Medical center; medical specialties; Medicine; methamphetamine use; multidisciplinary; National Institute of Drug Abuse; New England; new technology; novel strategies; Operative Surgical Procedures; Opiate Addiction; opioid misuse; Patient Care; patient registry; Patients; Pediatric Research; peer; Peer Review; Play; Population; pragmatic trial; Pregnancy; Pregnant Women; prenatal cigarette smoking; Primary Health Care; Productivity; Psychiatric therapeutic procedure; Public Health; public health relevance; Publications; recruit; Research; Research Infrastructure; Research Personnel; Research Project Grants; Risk; rural area; screening and brief intervention; Seminal; Series; Site; Smoking; smoking cessation; standard of care; Substance Use Disorder; System; treatment program; trend; United States; Universities; Veterans; virtual; Work; ","The National Drug Abuse Treatment Clinical Trials Network","015831","ZDA1","Special Emphasis Panel ","","S6","17","50609","21175","71784",""
"9917054","UG1","DA","3","N","04/25/2019","02/15/2019","05/31/2019","279","UG1DA040314","","RFA-DA-15-008","3UG1DA040314-04S6","NIDA:127236\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","OAKLAND","UNITED STATES","","13","150829349","US","3497005","KAISER FOUNDATION RESEARCH INSTITUTE","CA","946123466","PUBLIC HEALTH RELEVANCE:  The vision of the proposed Addiction Research Network (ARN) node of the Clinical Trials Network is to expand access and transform substance use treatment through integrating it into real-word medical settings. Through its network of 15 learning healthcare systems and electronic health record data, the ARN node will conduct research that identifies and implements multiple effective treatment options for patients. As part of the CTN, the ARN node will help build the infrastructure required for the next era of addiction health services research both nationally and internationally.","1903789; 2201444 (contact); 1877432; ","BRADLEY, KATHARINE ANTHONY; CAMPBELL, CYNTHIA I (contact); WEISNER, CONSTANCE M.;","DOBBINS, RONALD","09/01/2015","05/31/2020","Accident and Emergency department; addiction; Address; Adolescent; Adult; Age; alcohol misuse; Alcohol or Other Drugs use; Behavior Therapy; Biometry; Calibration; Cancer Research Network; Caring; Childhood; Chronic Disease; Clinical; clinical care; Clinical Trials Network; Comorbidity; comparative effectiveness; Data; data warehouse; design; Development; Diabetes Mellitus; Economics; effective intervention; effective therapy; effectiveness research; eHealth; Electronic Health Record; Ensure; ethnic diversity; evidence base; experience; Family Policy; Foundations; Future; Geography; Goals; Health; health care delivery; Health Care Reform; Health Services Research; Health system; Healthcare; Healthcare Systems; Hypertension; implementation research; improved; improved outcome; Influentials; Infrastructure; innovation; International; Lead; Learning; learning network; Measures; Medical; medical specialties; Mental Health; Minority; Monitor; Operative Surgical Procedures; opioid misuse; Outcome; Outcomes Research; Patient Monitoring; patient oriented; patient registry; Patient-Centered Care; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Policies; Population; population based; Population Study; Pragmatic clinical trial; pragmatic trial; Primary Health Care; Privatization; programs; Public Health; public health relevance; Quality of Care; racial and ethnic; Randomized Controlled Trials; Reporting; Research; Research Design; Research Methodology; Research Personnel; screening; Services; Severities; social stigma; study population; Substance Use Disorder; System; Testing; Time; United States; United States National Institutes of Health; Variant; virtual; Vision; Work; young adult; Youth; ","Integrating Addiction Research in Health Systems: The Addiction Research Network","040314","ZDA1","Special Emphasis Panel ","","S6","04","124244","2992","127236",""
"9918125","R25","MD","3","N","04/23/2019","04/23/2019","06/29/2020","663","R25MD010399","SCHOOLS OF ARTS AND SCIENCES","RFA-MD-15-005","3R25MD010399-04S1","OD:228762\","OTHER RESEARCH-RELATED","2019","National Institute on Minority Health and Health Disparities","","SAN JUAN","UNITED STATES","BIOLOGY","98","143960193","US","578706","UNIVERSITY OF PUERTO RICO RIO PIEDRAS","PR","009311790","Project Narrative The population of the US is over 14% Hispanic a number which is projected to grow in the coming years. However, Hispanics involvement in biomedical big data research is highly limited. This proposal addresses the need for training the next generation of Hispanic scientists in Biomedical Big Data Research to enhance the diversity of the scientific community in this biomedical area.","1929101 (contact); 11925184; 12593527; ","GARCIA-ARRARAS, JOSE E (contact); ORDONEZ, PATRICIA ; PÉREZ, MARIA-EGLEE ;","BERZON, RICHARD","04/23/2019","06/29/2020","20 year old; Address; Administrator; Americas; Area; Behavioral Research; big biomedical data; Big Data; Big Data to Knowledge; Biology; Biomedical Research; Biometry; California; Case Study; Clinical Research; cohort; Collaborations; college; Communities; Computational Biology; computer science; course module; Cultural Backgrounds; Data Science; Data Set; Development; digital; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Engineering; experience; Faculty; Goals; Grant; Hispanics; Infrastructure; Institution; interest; knowledge base; mathematical sciences; Mathematics; member; Mentors; Modernization; Molecular; Natural Sciences; next generation; online course; Piedra; Population; Preparation; programs; Puerto Rico; Research; Research Infrastructure; Research Personnel; response; Running; sabbatical; Science; Scientist; Series; Shapes; Site; skills; student training; Students; summer program; summer research; Techniques; Technology; Training; undergraduate student; Underrepresented Groups; United States; United States National Institutes of Health; Universities; Visit; Woman; Work; ","Increasing Diversity in Interdisciplinary BD2K (IDI-BD2K)","010399","ZRG1","Special Emphasis Panel ","","S1","04","215728","13034","228762",""
"9921210","I01","VA","5","N","04/25/2019","02/01/2019","01/31/2020","999","I01HX001260","","RFA-HX-14-002","5I01HX001260-05","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","PALO ALTO","UNITED STATES","","18","046017455","US","481014","VETERANS ADMIN PALO ALTO HEALTH CARE SYS","CA","943041207","Almost 11,000 total hip and knee replacement surgeries were conducted in VHA in 2011. Currently surgeons and patients have no systematic and validated method to estimate the patient-specific risks of the procedure (e.g., death, other complications including infection) or the estimated benefits for a specific patient. This project will take advantage of VA Surgical Quality Improvement and VA Corporate Warehouse data to develop and validate a surgical risk, benefit, and satisfaction calculator for total joint replacement candidates. Once developed, this decision-support tool can be used by surgeons and patients within a shared-decision making process to weigh the patient-tailored risks and probable benefits from total knee or hip replacement. The calculator will also help identify factors such as weight, smoking, and diabetic control that might be addressed prior to surgery in order to minimize risks and maximize the potential benefits of the procedure.","8613963; ","SOX-HARRIS, ALEX ;","","02/01/2015","09/30/2020","Acute; Address; Age; alcohol misuse; Arthroplasty, Replacement, Hip; base; Benefits and Risks; Body mass index; Cessation of life; Characteristics; Client satisfaction; Clinical; Clinical Data; clinical predictors; cost; Data; Data Set; data warehouse; Decision Support Systems; Degenerative polyarthritis; Development; Diabetes Mellitus; diabetic; Diagnosis; disability; Effectiveness; Electronic Health Record; Equilibrium; evidence base; expectation; follow-up; Goals; Health; health administration; Healthcare Systems; high risk; Hip Osteoarthritis; improved; Infection; Informed Consent; Knee Osteoarthritis; knee replacement arthroplasty; Link; Manuals; Methods; Modeling; modifiable risk; Obesity; Operative Surgical Procedures; Orthopedic Procedures; Orthopedics; Outcome; outcome prediction; Pain; Pain-Free; Patient Care; Patient Preferences; Patients; Population; Probability; Procedures; Process; Quality of life; recruit; Replacement Arthroplasty; Resources; Risk; Risk Factors; risk minimization; Safety; San Francisco; satisfaction; Schedule; shared decision making; Smoking; support tools; Surgeon; Symptoms; Testing; Total Hip Replacement; United States; Validation; Variant; Veterans; Weighing patient; Weight; ","Development and Validation of a Risk Calculator for Total Joint Replacement","001260","HSR1","HSR-1   Medical Care and Clinical Management ","","","05","","","",""
"9457158","R01","AR","5","N","04/26/2019","04/01/2019","03/31/2020","846","R01AR068279","SCHOOLS OF PHARMACY","PA-13-302","5R01AR068279-04","NIAMS:336600\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","LUBBOCK","UNITED STATES","OTHER BASIC SCIENCES","19","609980727","US","8285902","TEXAS TECH UNIVERSITY HEALTH SCIS CENTER","TX","794306271","PUBLIC HEALTH RELEVANCE: The macrophage is one of the critical regulators of the body's response to inflammation that contributes to the pathogenesis in arthritis. Recent studies from our group have identified a transcription factor KLF2 that regulates key aspects of macrophage biology. This proposal seeks to understand the mechanisms underlying the function of the transcription factor KLF2 with the goal of developing future alternate therapeutic approach by modulating KLF2 and their downstream targets for the treatment of rheumatoid arthritis in human.","8130459; ","DAS, HIRANMOY ;","MAO, SU-YAU","04/01/2016","03/31/2022","American; Applications Grants; Arthritis; base; Biology; Blood; BMP2 gene; cathepsin K; Cells; Cellular biology; chromatin immunoprecipitation; Co-Immunoprecipitations; Collagen-Induced Arthritis; Complex; Disease; disorder control; Embryo; EP300 gene; Exhibits; Experimental Arthritis; Experimental Designs; Family; Fibroblasts; Future; gain of function; gene function; gene repression; Genetic Transcription; Goals; Hematopoietic; Histologic; Histone Deacetylase; Histone Deacetylase Inhibitor; Human; Immune; Immune system; In Vitro; in vivo; Infiltration; Inflammation; Inflammatory; interest; Joints; K/BxN model; Knockout Mice; Knowledge; Kruppel-like transcription factors; loss of function; macrophage; Mediating; member; microCT; MMP9 gene; Molecular; monocyte; Mus; Myelogenous; Myeloid Cell Activation; Myeloid Cells; NF-kappa B; novel; osteoclastogenesis; Osteoclasts; Pathogenesis; Pathway interactions; Patients; PCAF gene; peripheral blood; Pharmacology; Play; Process; public health relevance; Radiology Specialty; recruit; Regulation; Reporting; response; Rheumatoid Arthritis; Role; Serum; soft tissue; Structure; Therapeutic; Tissues; TNFSF11 gene; transcription factor; Transcription Factor AP-1; Zinc Fingers; ","Myeloid KLF2 regulation mechanisms in rheumatoid arthritis","068279","AICS","Atherosclerosis and Inflammation of the Cardiovascular System Study Section ","","","04","220000","116600","336600",""
"9572663","P30","EY","2","N","04/25/2019","04/01/2019","03/31/2020","","P30EY008098","","PAR-17-322","2P30EY008098-31","NEI:180314\","RESEARCH CENTERS","2019","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","14","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152132303","","1893838; ","KINCHINGTON, PAUL R.;","","","","Bioinformatics; Biological Assay; CLC Gene; Complex; Consult; Core Grant; Data; design; Development; DNA; Environment; Equipment; Evaluation; experience; Experimental Designs; Faculty; Gene Expression Profiling; Genomics; Learning; Libraries; Methodology; Methods; Mind; Molecular; molecular array; Molecular Biology; Molecular Evolution; nano-string; next generation; next generation sequencing; Pathway interactions; Preparation; programs; Quantitative Reverse Transcriptase PCR; Research Personnel; Research Project Grants; Resources; RNA; RNA analysis; Sampling; Services; Supercomputing; System; Techniques; Technology; tool; Training; transcriptomics; Universities; Viral; Vision; Vision research; vision science; ","Molecular Biology Core","008098","ZEY1","Special Emphasis Panel ","5951","","31","120895","59419","","180314"
"9702794","P30","DK","5","N","04/24/2019","04/01/2019","03/31/2020","","P30DK057521","","RFA-DK-13-004","5P30DK057521-20","NIDDK:156600\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","","1860726; ","LOWELL, BRADFORD B;","","","","Address; Alleles; Area; blood glucose regulation; Boston; Bypass; cancer cell; Cells; Cellular Metabolic Process; clinical investigation; Consultations; CRISPR/Cas technology; Cryopreservation; Development; Diabetes Mellitus; DNA; embryonic stem cell; Endocrinology; Engineering; Fee-for-Service Plans; feeding; Fertilization in Vitro; Funding Mechanisms; Gene Targeting; Genes; Genetic; Grant; Hunger; Immunology; Injections; Journals; Knock-in; Knock-in Mouse; knockout gene; Knockout Mice; Length; Medicine; member; Metabolism; mind control; Molecular; Monoclonal Antibody R24; mouse genome; Mus; mutant; Nature; Neurons; Neurosciences; new technology; nutrition; Obesity; Publications; Research; Research Personnel; Research Project Grants; Rewards; Science; Services; Time; Training; Transgenic Organisms; United States National Institutes of Health; ","Transgenic Core","057521","ZDK1","Special Emphasis Panel ","7733","","20","156600","0","","156600"
"9708219","R01","HL","1","N","04/22/2019","04/23/2019","03/31/2020","838","R01HL146461","SCHOOLS OF MEDICINE","PA-18-484","1R01HL146461-01","NHLBI:524789\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BIRMINGHAM","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive, and ultimately fatal disorder with a poorly understood pathogenesis and no cure. IPF lungs feature honeycomb regions, which are lined with confused conducting airway epithelial cells stuck in an indeterminate state of differentiation. This grant proposal seeks to determine the role of Hippo signaling in regulating alveolar epithelial regeneration by bronchial and alveolar epithelial stem cells after bleomycin injury.","9220162; ","DE LANGHE, STIJN PIET JOHAN;","LIN, SARA","04/23/2019","03/31/2023","Age; AGTR2 gene; airway remodeling; Alveolar; Applications Grants; Architecture; Attenuated; Basal Cell; beta catenin; Bleomycin; Cartoons; cell dedifferentiation; Cell Density; Cell Differentiation process; Cell Lineage; Cell Maintenance; Cell physiology; cell type; Cells; Cessation of life; Characteristics; Chronic; Data; Development; Diagnosis; Disease; Epithelial; Epithelial Cells; Failure; Fibrosis; Gene Expression; Genetic; genome-wide; Goblet Cells; HIF1A gene; Histologic; Homeostasis; idiopathic pulmonary fibrosis; Impairment; Individual; Inflammation; Influenza; Injury; Interstitial Lung Diseases; Invaded; Lesion; Lung; lung development; lung injury; Mediating; Mesenchymal; Modeling; Molecular; Monitor; Mus; Natural regeneration; notch protein; Nuclear; Pathogenesis; Pathway interactions; Patients; Phosphotransferases; premature; Pulmonary Fibrosis; pulmonary function; regenerative; repaired; Reporting; Resolution; respiratory; Respiratory Failure; response; Role; role model; Signal Transduction; Stem cells; Structure; Structure of parenchyma of lung; Structure of respiratory epithelium; Testing; tool; transcriptomics; Use of New Techniques; ","Epithelial stem cell hippo signaling in pulmonary fibrosis","146461","LIRR","Lung Injury, Repair, and Remodeling Study Section ","","","01","355288","169501","524789",""
"9710563","P30","AG","1","N","04/26/2019","04/01/2019","03/31/2020","","P30AG062422","","RFA-AG-19-001","1P30AG062422-01","NIA:638788\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","1959312; ","MILLER, BRUCE L;","","","","Advisory Committees; Alzheimer's Disease; Amyloid beta-Protein; Autophagocytosis; Award; base; behavioral neurology; Biological Markers; brain health; career; Caregiver support; Caring; CASP3 gene; Chinese People; Clinical; Clinical Research; Clinical Trials Network; Clustered Regularly Interspaced Short Palindromic Repeats; Cognitive; cognitive testing; Collaborations; Communication Tools; Communities; Computers; corticobasal degeneration; Creativeness; Creutzfeldt-Jakob Syndrome; data management; Dementia; Development; Education; Education and Outreach; education research; Ensure; Environment; Ethics; Evaluation; Faculty; faculty support; Family Caregiver; Fostering; Frontotemporal Dementia; Funding; Gifts; Goals; Grant; Heterogeneity; Home environment; Human; imager; improved; induced pluripotent stem cell; Industry; Infrastructure; innovation; Institutes; interdisciplinary approach; Interdisciplinary Study; International; Knowledge; Latino; Leadership; Mentors; Mid-Career Clinical Scientist Award (K24); mild cognitive impairment; Monitor; Nature; nervous system disorder; neuroimaging; Neurologist; neuropathology; Neurosciences; next generation; normal aging; novel; novel strategies; Nurses; Organization administrative structures; Outcome; Patients; PGRN gene; Phenotype; Policies; Primary Health Care; Prions; Procedures; Process; Productivity; programs; Progressive Supranuclear Palsy; ranpirnase; Rare Diseases; Regulation; Reporting; Research; Research Personnel; Research Training; Resource Sharing; Resources; Sampling; San Francisco; Science; Scientist; screening; Seizures; Services; sharing data; square foot; Strategic Planning; success; tau Proteins; Technology; therapy development; Time; Training; Training Programs; United States National Institutes of Health; Vascular Dementia; Vulnerable Populations; Work; ","Core A: Administrative Core","062422","ZAG1","Special Emphasis Panel ","5033","","01","398205","240583","","638788"
"9716955","R01","MD","1","N","04/26/2019","04/26/2019","12/31/2019","307","R01MD013881","","PAR-18-288","1R01MD013881-01","NIMHD:575706\","Non-SBIR/STTR RPGs","2019","National Institute on Minority Health and Health Disparities","","COLUMBUS","UNITED STATES","","03","147212963","US","1495302","RESEARCH INST NATIONWIDE CHILDREN'S HOSP","OH","432052664","Project Narrative  Among young adults, patients who are uninsured, reside in low income areas, or are black or Hispanic have worse outcomes after serious injury. Prior to the implementation of the Affordable Care Act (ACA), more than 20% of hospitalized trauma patients were uninsured, with this proportion being much higher among low income and racial/ethnic minority patients. This study aims to evaluate whether ACA Medicaid expansion has mitigated some of the disparities in trauma care and outcomes after serious injury for Non-Hispanic black patients, Hispanic patients, and patients residing in low income communities.","10305200; ","COOPER, JENNIFER N.;","DAGHER, RADA KAMIL","04/26/2019","12/31/2021","Accident and Emergency department; Accounting; Acute; Admission activity; Adult; Affect; Affordable Care Act; aged; American Hospital Association; Area; care outcomes; Caring; Cause of Death; Cessation of life; Characteristics; Communities; Community Hospitals; Complex; cost; Data; Data Linkages; Databases; disability; disparity reduction; Elderly; Emergency department visit; Emergency Situation; ethnic minority population; Evaluation; experience; Failure; Federal Government; Financial cost; follow-up; Future; Geographic state; Geography; Goals; health care disparity; Health Insurance; Health Personnel; Health Services Accessibility; Health Status; high risk; Hispanics; Hospital Costs; Hospital Mortality; Hospital Readmission; Hospitalization; Hospitals; Improve Access; improved; injured; Injury; Inpatients; Insurance; Insurance Coverage; longitudinal analysis; Low income; low socioeconomic status; Medicaid; Medical; Military Personnel; Minority; mortality; Not Hispanic or Latino; Operative Surgical Procedures; Outcome; Outpatients; Patients; Pattern; Policies; Policy Maker; Policy Making; Population; Preventive healthcare; Provider; Race; racial and ethnic; racial and ethnic disparities; racial disparity; readmission rates; Registries; Rehabilitation therapy; rehabilitative care; Reporting; Research; Resources; rural area; rural patients; safety net; Social Class; socioeconomic disparity; socioeconomics; Surveys; Time; Trauma; trauma care; trauma centers; Trauma patient; Traumatic injury; Uninsured; United States; waiver; Work; young adult; ","Effects of Affordable Care Act Medicaid Expansion on Disparities in Trauma Care and Outcomes in Young Adults","013881","ZRG1","Special Emphasis Panel ","","","01","378754","196952","575706",""
"9729348","U19","AI","2","N","04/22/2019","04/25/2019","03/31/2020","","U19AI110818","","RFA-AI-18-004","2U19AI110818-06","NIAID:573303\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","","07","623544785","US","10021177","BROAD INSTITUTE, INC.","MA","021421027","","1922265; ","BIRREN, BRUCE W.;","","","","Achievement; Address; base; Bioinformatics; Cells; Collaborations; combat; Communicable Diseases; Communication; Communities; Complex; Computer Analysis; Data; Education and Outreach; Educational Activities; Educational workshop; Ensure; experience; fighting; Funding; Future; genomic data; Genomics; Goals; improved; Individual; Industry; Infectious Diseases Research; innovation; interest; Knowledge; Laboratories; Leadership; member; Methods; Mission; Monitor; National Institute of Allergy and Infectious Disease; Nature; novel; organizational structure; outreach; outreach program; pathogen; Performance; Pilot Projects; Population; Practice Management; Process; programs; Recording of previous events; Reporting; Research; research and development; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Scientist; Shapes; success; Talents; Technology; TimeLine; tool; Training; Training Programs; undergraduate student; Underrepresented Groups; vector; Visit; Work; working group; ","Admin Core","110818","ZAI1","Special Emphasis Panel ","5975","","06","341503","231800","","573303"
"9729353","U19","AI","2","N","04/22/2019","04/25/2019","03/31/2020","","U19AI110818","","RFA-AI-18-004","2U19AI110818-06","NIAID:738128\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","","07","623544785","US","10021177","BROAD INSTITUTE, INC.","MA","021421027","","9367266; ","CUOMO, CHRISTINA A;","","","","Address; Animal Model; Antifungal Agents; Antifungal Therapy; Area; Blood; Blood Circulation; Candida; candidemia; Cells; Central Nervous System Infections; Cessation of life; chronic infection; Clinical; Clinical Treatment; Clinical Trials; cohort; Collection; combat; Communicable Diseases; Cryptococcus; Cryptococcus neoformans; Data; deletion library; Development; Diagnosis; Drug resistance; effective therapy; Evolution; Fungal Drug Resistance; fungus; Gastrointestinal tract structure; Gene Deletion; Gene Expression; Gene Expression Regulation; Genes; Genetic; Genetic study; Genetic Transcription; Genetic Variation; Genome; genome sequencing; genome wide association study; genome-wide; Genomic approach; genomic data; Genomics; Growth; Health; Heterogeneity; High-Throughput Nucleotide Sequencing; host microbiome; Human; Hybrids; Immune response; Immunocompromised Host; in vivo; Individual; individual patient; Infection; Innate Immune Response; Intervention; Lung infections; Maps; Measures; Mediating; Metadata; Metagenomics; Methods; microbiome; Monitor; mortality; mycobiome; Mycoses; Neuraxis; novel strategies; Outcome; pathogen; Pathogenesis; pathogenic fungus; Patient Isolators; Patients; Penicillium; Phenotype; phenotypic data; Population; Population Study; Property; prospective; reference genome; response; Risk Factors; Sampling; Sepsis; Site; Skin; Stream; synergism; Talaromyces; Technology; Testing; transcriptome sequencing; transcriptomics; trial comparing; Variant; Virulence; Virulent; whole genome; Work; ","Project 3 Population studies of major human fungal pathogens: genomic and transcriptomic analyses of interactions with the host and microbiome and the rise of antifungal resistance","110818","ZAI1","Special Emphasis Panel ","5980","","06","467962","270166","","738128"
"9729354","U19","AI","2","N","04/22/2019","04/25/2019","03/31/2020","","U19AI110818","","RFA-AI-18-004","2U19AI110818-06","NIAID:614072\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","","07","623544785","US","10021177","BROAD INSTITUTE, INC.","MA","021421027","","9621853; ","NEAFSEY, DANIEL E;","","","","Africa; analytical method; Anopheles Genus; Biological; Cells; Cessation of life; Clinical; Collaborations; Collection; combat; commune; Communicable Diseases; comparative; Culicidae; Data Set; Developing Countries; Disease; DNA Resequencing; Economics; effective therapy; Epidemiology; Evolution; Face; Gabon; Generations; Genes; Genetic; Genetic Transcription; genome sequencing; genomic data; genomic epidemiology; genomic profiles; genomic signature; Genomics; Geography; Health Services Accessibility; Hepatocyte; Human; Immunity; improved; In Vitro; Individual; innovation; insight; Intervention; Liver; liver infection; Malaria; malaria infection; Measures; Mediating; Metabolic; Methods; Morbidity - disease rate; mortality; novel; Parasite Control; Parasites; Parasitic Diseases; Pharmaceutical Preparations; Pharmacotherapy; Plasmodium; Plasmodium falciparum; Plasmodium vivax; Population; population based; Population Sizes; practical application; pressure; programs; Public Health; reference genome; Resource Development; Resources; response; sample collection; Signal Transduction; Structure; System; Technology; technology development; trait; transcriptomics; transmission process; vector; vector control; vector mosquito; whole genome; Work; World Health Organization; ","Project 4 Genomic and transcriptomic interactions between malaria parasites, their mosquito vectors, and human hosts at the scale of continents, villages, and single cells","110818","ZAI1","Special Emphasis Panel ","5981","","06","439358","174714","","614072"
"9745903","R21","AI","1","N","04/23/2019","04/23/2019","03/31/2020","855","R21AI137790","","PA-18-489","1R21AI137790-01A1","NIAID:222500\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW YORK","UNITED STATES","","12","073271827","US","1782801","NEW YORK BLOOD CENTER","NY","100656275","Project Narrative Zika virus (ZIKV) infection has severe consequences, such as tissue and fetal damage, fetal and pup death, brain abnormalities, and other malformations. The proposed study aims to rationally design and rapidly develop a novel and effective anti-ZIKV therapeutic nanobody with unique properties able to prevent the severe diseases noted above, and protect pregnant women, as well as their fetuses and babies, against ZIKV infection. This study will also strengthen the fight against other emerging and reemerging infectious diseases with pandemic potential.","9930153; ","DU, LANYING ;","DAVIS, MINDY I","04/23/2019","03/31/2021","Affect; Affinity; Animal Model; Antibodies; Antibody-Dependent Enhancement; Attention; base; Behavior; Binding; Biological Assay; Blood; Brain; brain abnormalities; Brain Injuries; Cessation of life; Characteristics; Chemicals; Chlorides; Clinical; Communicable Diseases; Congenital neurologic anomalies; congenital zika syndrome; Country; design; Development; Disease; Drug or chemical Tissue Distribution; Engineering; env Gene Products; Evaluation; experience; fetal; Fetal Death; Fetus; fight against; Flavivirus; Generations; Goals; Grant; guanidinium; Guidelines; Half-Life; High temperature of physical object; Human; human disease; immunogenicity; Immunoglobulin G; improved; In Vitro; in vivo; malformation; Microcephaly; Middle East Respiratory Syndrome Coronavirus; Monoclonal Antibodies; mouse model; Mus; Mutation; nanobodies; Nervous system structure; Neuraxis; Neurologic; Neurons; neutralizing monoclonal antibodies; Newborn Infant; novel; Organ; pandemic disease; Pathogenicity; Penetration; Peptide Hydrolases; Permeability; Placenta; pre-clinical; pregnant; Pregnant Women; prevent; Property; pup; reproductive; reproductive organ; Reproductive system; Research; Specificity; Structure; success; Testing; Therapeutic; Therapeutic Agents; Therapeutic antibodies; therapeutic vaccine; Time; Tissues; tool; Toxic effect; type I interferon receptor; Urea; Vaccines; Vertical Disease Transmission; Viral Pathogenesis; Virus; virus envelope; Zika Virus; ZIKV infection; ","A novel and effective nanobody to prevent and treat Zika virus infection","137790","ZRG1","Special Emphasis Panel ","","A1","01","125000","97500","222500",""
"9759498","F32","HD","1","N","03/27/2019","03/27/2019","03/26/2020","865","F32HD098808","SCHOOLS OF MEDICINE","PA-18-670","1F32HD098808-01","NICHD:64310\","TRAINING, INDIVIDUAL","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","STANFORD","UNITED STATES","NEUROLOGY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943041222","Project Narrative This research aims to advance our understanding of biological pathways related to rehabilitation strategies (i.e. electrical modulation and physical exercise) and stem cells, and their combined therapeutic benefits for improving nerve regeneration and functional recovery in animal models with peripheral nerve injury. The knowledge of how to improve the therapeutic effectiveness of transplanted human neural stem cells (hNSCs) is limited. A better understanding of hNSCs' response to their microenvironment through electrical modulation and physical rehabilitation will provide discoveries and insights on new device approaches and drug candidates for neural recovery and nerve regeneration. These advances will translate into better therapies for patients with peripheral nerve injury.","11083103; ","SONG, SHANG ;","BONNER, JOSEPH FRANCIS","03/27/2019","03/26/2022","Accidents; Acute; Adult; Animal Model; Behavior; behavior test; Biochemical; bioelectricity; Biological; Biomedical Engineering; Biophysics; Birth; Blood Vessels; Brachial plexus structure; Cell Communication; Cell Differentiation process; Cell Membrane Permeability; Cell Survival; Cells; Child; Childhood; Cicatrix; combat; Complex; cost; Coupled; Cues; cytokine; Defect; Devices; disability; drug candidate; Effectiveness; Electric Stimulation; electrical potential; Electrophysiology (science); Encapsulated; Engineering; Europe; excitotoxicity; Exposure to; Fostering; Goals; Gold; Graft Survival; Harvest; Healthcare Systems; Human; Immune; Immune response; Implant; improved; In Vitro; in vivo; Infiltration; Inflammatory; Inflammatory Response; Injury; injury and repair; insight; Knowledge; Left; Location; Longevity; Mediator of activation protein; Membrane; Methods; Modeling; Molecular Analysis; Motor Vehicles; Muscle; Muscular Atrophy; nanopore; Nature; Nerve; nerve injury; Nerve Regeneration; nerve stem cell; nerve supply; neuromuscular; Neurons; neurotrophic factor; Neurotrophin 3; NTF3 gene; Operative Surgical Procedures; Oxidative Stress; Pathway interactions; Patients; Peripheral nerve injury; peripheral nerve regeneration; Peripheral Nerves; Physical Exercise; Physical Rehabilitation; Population; prevent; Process; Production; Proteins; Rattus; Recovery; Recovery of Function; regenerative; rehabilitation strategy; Rehabilitation therapy; relating to nervous system; release factor; repaired; Research; response; Role; sciatic nerve; Silicon; Site; Spinal; stem cell therapy; Stem cells; Synapses; Techniques; Therapeutic; therapeutic effectiveness; TNF gene; Training; Translating; Transplantation; Trauma; treatment optimization; tumor; vehicular accident; Withdrawal; Work; ","Enhanced Stem Cell Therapy with Rehabilitation Strategies for Peripheral Nerve Regeneration","098808","ZRG1","Special Emphasis Panel ","","","01","64310","","64310",""
"9823541","R01","DA","3","N","04/22/2019","01/01/2019","12/31/2019","279","R01DA044971","SCHOOLS OF MEDICINE","PA-18-906","3R01DA044971-02S1","NIDA:34833\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","MILWAUKEE","UNITED STATES","PSYCHIATRY","05","937639060","US","46001","MEDICAL COLLEGE OF WISCONSIN","WI","532263548","In response to rising rates of opioid dependence and fatal poisonings, virtually every US state has incorporated laws to reduce the availability of medical opioids for diversion. However, little research has examined the effects of these laws on the transition to injecting opioids or heroin. To our knowledge, the proposed research is the only study to date that will examine the effects of state laws and policies on transition to injection of prescription opioids or heroin. This will allow us to identify multiple points of intervention at the policy level in ways that will maximize benefits and minimize potential harms, and adapting harm reduction services to new contexts.","6858396; ","DICKSON-GOMEZ, JULIA B;","FLOURNOY FLOYD, MINNJUAN WYNCEPHEL","04/01/2018","12/31/2022","Accident and Emergency department; addiction; Admission activity; Affect; aged; Area; base; Blood; Buprenorphine; Connecticut; County; Data Collection; density; design; Diffusion; Doctor shopping; Drug usage; Emergency treatment; Epidemic; Geographic state; Harm Reduction; Health; Hepatitis; Hepatitis C; Hepatitis C Transmission; Heroin; heroin use; Heroin Users; HIV Infections; HIV/HCV; Indiana; Infection; injection drug use; Injections; Insurance; Intervention; Kentucky; Laws; Medicaid; Medical; men; Meta-Analysis; Methadone; Methods; metropolitan; Needle-Exchange Programs; Opiate Addiction; Opioid; opioid injection; opioid misuse; opioid policy; opioid treatment program; opioid use; Opioid user; Oral; overdose death; Pain Clinics; Patients; Perception; Pharmaceutical Preparations; Pharmacotherapy; Pharmacy facility; Phase; Physicians; Play; Poisoning; Policies; prescription monitoring program; prescription opioid; prescription opioid misuse; Prescription opioid overdose; prevention service; Price; prior authorization; Privatization; Probability; programs; Public Health; Regulation; Reporting; Research; response; Risk; Role; Rural; rural area; Services; Social Network; Sterility; suburb; Surveys; Syringes; System; Testing; transmission process; treatment program; urban area; Vaccination; virtual; Water; Wisconsin; Woman; ","Effects of State Laws to Reduce Opioid Diversion on Transitions to Injection Drug Use and HIV/HCV Transmission","044971","ZRG1","Special Emphasis Panel ","","S1","02","22619","12214","34833",""
"9853679","UG1","DA","3","N","04/22/2019","02/15/2019","05/31/2019","279","UG1DA040309","SCHOOLS OF MEDICINE","PA-18-591","3UG1DA040309-04S4","NIDA:205980\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","HANOVER","UNITED STATES","PSYCHIATRY","02","041027822","US","2021601","DARTMOUTH COLLEGE","NH","037551421","Project Narrative The National Institute on Drug Abuse?s (NIDA?s) Clinical Trials Network (CTN) conducts practical trials evaluating screening, prevention, treatment, and recovery support interventions for substance use disorders (SUDs) in real-world community systems across the nation. The proposed Northeast Node of the CTN will enable an expanded focus of CTN activities on technology-based interventions for SUDs, SUD care for adolescents, and SUD care for rural communities. Through these activities, the Node seeks to create new knowledge to inform unprecedented, science-based treatment of SUDs and serve as a resource for science, education, services, and tools for the national CTN community and substance abuse field.","2102065; ","MARSCH, LISA A.;","DOBBINS, RONALD","09/01/2015","05/31/2020","Achievement; addiction; Adolescent; adolescent substance use; Adult; aged; Alcohol or Other Drugs use; American; Analgesics; base; Behavioral; behavioral health; care coordination; care systems; Caring; Chronic; chronic pain patient; Clinical; Clinical Trials Network; Collaborations; college; Communities; Community Networks; Comorbidity; Cost effectiveness research; Criminal Justice; Development; Drug abuse; Drug user; Effectiveness; effectiveness trial; Evaluation; evidence base; Funding; Geographic Locations; Healthcare Systems; HIV; HIV risk; Home environment; Hospitals; illicit drug use; implementation research; Individual; Infrastructure; insight; Internet; Intervention; Knowledge; Leadership; Maine; Managed Care; marijuana use; Medical; medical specialties; Mental disorders; Mental Health; Modeling; National Clinical Trials Network; National Institute of Drug Abuse; New Hampshire; opioid use disorder; payment; Persons; Pharmaceutical Preparations; Pharmacology; Policies; Population; Practical trial; prescription opioid; Prevention; primary care setting; Primary Health Care; Principal Investigator; programs; provider networks; Public Health; ranpirnase; Recovery; Research; research and development; Research Infrastructure; Research Support; Resources; Risk; Risk Behaviors; Role; rural area; Rural Community; rural healthcare; Sample Size; Sampling; Schools; Science; science education; screening; Seminal; service delivery; Services; Site; Smoker; Substance abuse problem; substance abuse treatment; Substance Use Disorder; synergism; System; Technology; technology validation; Therapeutic; therapy development; Time; tool; Tranquilizing Agents; Vermont; Veterans; Work; Youth; ","Northeast Node of the National Drug Abuse Clinical Trials Network","040309","","","","S4","04","143264","62716","205980",""
"9567445","U01","GH","5","N","04/24/2019","09/30/2018","09/29/2019","326","U01GH002223","","RFA-GH-17-003","5U01GH002223-02","ODCDC:1\","Non-SBIR/STTR RPGs","2019","Center for Global Health","","JOHANNESBURG","SOUTH AFRICA","","","652813872","SF","10023406","NATIONAL HEALTH LABORATORY SERVICE","","2192","Project Narrative lconducting Public Health Research in 11= Add Attachment 111 Delete Attachment i I View Attachment ~ 9. Bibliography & References Cited ' ' I Add Attachment 111 Delete Attachment~ I View Attach~Qt.] 10. Facilities & Other Resources Add Attachment JI I Delete Attachm!0] I View Attach~ent 11. Equipment Add Attachment ~ I Delete Attachment! I View Attachment J 12. Other Attachments Add Attachme~JI 1£?1ete Attachmentsll I View Attachments II D  OMB Number: 4040-0010  Expiration Date: 10/31/2019","11296362; ","MAYET, NATALIE ;","","09/30/2017","09/30/2022","","GH17-003, S. Africa:  SUPPORTING THE NATIONAL HEALTH LABORATORY SERVICES TO EXPAND PUBLIC HEALTH RESEARCH ON FIELD AND LAB INVESTIGATIONS","002223","ZGH1","Special Emphasis Panel ","","","02","","","1",""
"9654010","SC3","GM","5","N","04/26/2019","03/01/2019","02/28/2021","859","SC3GM116684","SCH ALLIED HEALTH PROFESSIONS","PAR-14-018","5SC3GM116684-04","NIGMS:112500\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","SAN JUAN","UNITED STATES","OTHER HEALTH PROFESSIONS","98","948108063","US","578705","UNIVERSITY OF PUERTO RICO MED SCIENCES","PR","009365067","PUBLIC HEALTH RELEVANCE:  Women who survive breast cancer treatment face high risk for a broad range of chronic diseases associated with reduced physical functioning. These poor outcomes can be prevented through engagement and adherence to an exercise program. The proposed study will develop and test the effect of two viable theory- based interventions to improve physical functioning among female breast cancer survivors. The study will provide initial data on the impact of the interventions, and is expected to yield findings relevant to reducing health disparities among Hispanic women. The project is relevant to the NIH's mission, particularly in reducing the cancer-related burden among minority women.","10085404; ","MULERO-PORTELA, ANA L;","KRASNEWICH, DONNA M","03/11/2016","02/28/2021","Address; Adherence; Adjuvant Therapy; Age; Age-Years; American Cancer Society; arm; Attitude; base; Behavior; behavior change; Behavior Control; Behavioral; Blinded; Breast Cancer Patient; Breast Cancer Rehabilitation; Breast Cancer survivor; Breast Cancer Treatment; cancer diagnosis; Cancer Patient; cancer therapy; Caring; Chronic; Chronic Disease; Clinical; Correlation Studies; Data; design; Diagnosis; Dose; Early Diagnosis; Early treatment; Elderly; endurance exercise; Evaluation; Exercise; exercise adherence; exercise intensity; Exercise intervention; exercise program; Experimental Designs; Face; Female Breast Carcinoma; follow-up; Future; Guidelines; Hair; Health Benefit; health disparity; Health Professional; health related quality of life; high risk; Hispanics; Home environment; improved; Intervention; intervention effect; Literature; Long-Term Effects; malignant breast neoplasm; Malignant Neoplasms; Measures; Mediating; Mediator of activation protein; Mental Health; Methodology; middle age; Minority; Mission; Not Hispanic or Latino; Operative Surgical Procedures; Outcome; Outcome Measure; Participant; Patients; Physical Function; physical therapist; Planning Theory; Population; prevent; primary outcome; public health relevance; Puerto Rico; Randomized; Randomized Controlled Trials; Recommendation; relative effectiveness; Research; Sampling; Societies; Survivors; survivorship; Testing; theories; Time; Treatment outcome; United States; United States National Institutes of Health; Woman; ","Effect of low-intensity versus moderate-intensity endurance exercise on physical functioning among breast cancer survivors: a randomized controlled trial","116684","ZGM1","Special Emphasis Panel ","","","04","75000","37500","112500",""
"9665144","U19","AI","1","N","04/22/2019","04/01/2019","03/31/2020","","U19AI142636","","PAR-15-330","1U19AI142636-01","NIAID:1214475\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAN ANTONIO","UNITED STATES","","23","007936834","US","7660801","TEXAS BIOMEDICAL RESEARCH INSTITUTE","TX","782450549","","15411106; ","FLEURY, SYLVAIN ;","","05/01/2019","04/30/2024","Acquired Immunodeficiency Syndrome; Adjuvant; Adult; Agonist; Agreement; analytical method; Antigens; base; Biomedical Research; capsule; CD4 Positive T Lymphocytes; Child; clinical development; Cold Chains; cold temperature; Collaborations; Contracts; Development; Distant; dosage; Dosage Forms; efficacy study; Enteral; Epidemic; Epithelium; Formulation; Generations; Genital system; Goals; Gut associated lymphoid tissue; HIV; HIV Antigens; HIV Envelope Protein gp41; HIV vaccine; HIV Vaccine Trials Network; HIV-1; HIV-1 vaccine; Human; ileum; immune activation; Immunization; immunogenic; immunogenicity; improved; in vivo; Infant; Infection; Influenza; innovation; Intestinal Mucosa; Intestines; Intramuscular; Label; Lead; Liquid substance; lymph nodes; Macaca mulatta; manufacturing process; Membrane; men; migration; Modeling; Mucosal Immune System; mucosal site; mucosal vaccine; Mucous Membrane; Needles; nonhuman primate; Nose; novel; novel vaccines; Oral; particle; phase I trial; Play; Polymers; Population; Powder dose form; prevent; Preventive vaccine; Process; programs; reconstitution; rectal; research clinical testing; Research Institute; Research Personnel; response; Route; Safety; sexual HIV transmission; Sexual Transmission; Site; Small Intestines; Solid; Structure; Subunit Vaccines; Surface; Tablets; Teenagers; Temperature; Testing; Texas; thermostability; Tissues; TLR7 gene; Toxicology; vaccine candidate; vaccine delivery; vaccine development; Vaccine Production; Vaccines; Viral Antibodies; viral transmission; Virosome Vaccines; Virosomes; Virus; Woman; Work; ","Vaccine development and production","142636","ZAI1","Special Emphasis Panel ","6242","","01","1191600","22875","","1214475"
"9665266","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:443370\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","7182203; ","WILKINS, CONSUELO HOPKINS;","","","","Address; Affect; African American; Collaborations; collaborative environment; Communication; Communities; Consultations; Data; Development; Discipline; Doctor of Philosophy; Elements; Ensure; Environment; experience; General Population; Genetic; genome sciences; Goals; health disparity; health equity; Health Personnel; Human; Immunologist; Incentives; Infrastructure; innovation; Institutes; Institution; Language; Latino; Leadership; medical schools; Medicine; meetings; member; Methods; Molecular; novel; Outcome; Perception; population health; Precision Health; precision medicine; Problem Solving; programs; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rewards; Schools; Science; skills; Strategic Planning; tool; translational scientist; Universities; user-friendly; virtual; Vision; ","Administrative Core","010722","ZMD1","Special Emphasis Panel ","8199","","04","375297","143272","","443370"
"9665268","U54","MD","5","N","04/24/2019","04/01/2019","03/31/2020","","U54MD010722","","RFA-MD-15-013","5U54MD010722-04","NIMHD:231026\","RESEARCH CENTERS","2019","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","7854859; ","KRIPALANI, SUNIL ;","","","","Address; Adoption; Area; Bioethics; Caring; Characteristics; Clinical Data; Communication; Communities; Decision Making; Diagnostic; Diffusion; Education; Ensure; Ethical Issues; Ethics; ethnic minority population; evidence base; Evidence based intervention; experience; Familiarity; Focus Groups; Fostering; Funding Mechanisms; General Population; Genetic; Genetic Medicine; Genetic screening method; genomic data; Genomics; Goals; Health; health disparity; health equity; health literacy; Health Personnel; Health Policy; Health Professional; Health Services Accessibility; implementation science; improved; Individual; Intervention; Knowledge; Language; Limited English Proficiency; Linguistics; literacy; Minority; Minority Groups; new technology; organizational structure; Patients; Perception; Policy Maker; Population; population health; precision medicine; Precision Medicine Initiative; Privacy; Process; programs; racial minority; Research; Research Project Grants; Resources; Series; social; Speed; Surveys; Therapeutic; Time; Training; Translating; Translations; Trust; Work; ","Implementation Core","010722","ZMD1","Special Emphasis Panel ","8201","","04","217162","48319","","231026"
"9666874","R01","CA","5","N","04/25/2019","04/01/2019","03/31/2020","394","R01CA131164","SCHOOLS OF MEDICINE","PA-13-302","5R01CA131164-10","NCI:337659\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","LITTLE ROCK","UNITED STATES","OTOLARYNGOLOGY","02","122452563","US","1471106","UNIV OF ARKANSAS FOR MED SCIS","AR","722057101","PUBLIC HEALTH RELEVANCE: The capability of a painless, noninvasive, labeling-free, photoacoustic flow cytometry for selective, time-resolved detection of photoacoustic signals from different vessels will be assessed in (1) white and black healthy volunteers and (2) melanoma patients at different stages of disease, in whom circulating metastatic melanoma cells will be quantitatively determined. In the course of this study, we will obtain statistically significant data that will demonstrate this innovative technique's unprecedented capability for quantitatively monitoring circulating melanoma cells in vivo without the need for labeling. The benefits to the public health of achieving this goal extend to the routine monitoring of circulatin cells as early markers of micrometastatic development and cancer recurrence in vivo in melanoma patients, as well as to evaluating the efficacy of therapy.","7748267; ","ZHAROV, VLADIMIR P;","OSSANDON, MIGUEL","12/01/2007","03/31/2020","absorption; Acoustics; Biological; Blood; Blood specimen; cancer diagnosis; Cancer Patient; cancer recurrence; Cell Count; Cell Line; Cell Size; Cells; Cellular Assay; Cessation of life; Clinical; Clinical Research; Clinical Trials; cohort; Complex; Control Groups; conventional therapy; Cutaneous Melanoma; Data; Detection; Development; Diagnosis; Diagnostic; Disease; Distant; Early Diagnosis; Epidemic; Family suidae; Flow Cytometry; Goals; healthy volunteer; Human; Human Volunteers; improved; In Vitro; in vivo; in vivo evaluation; Incidence; Individual; innovation; Label; Lasers; light scattering; Malignant Neoplasms; Melanins; melanoma; Melanoma Cell; metastasis prevention; Metastatic Melanoma; Methods; Monitor; nanobubble; Neoplasm Circulating Cells; Neoplasm Metastasis; Operative Surgical Procedures; Optical Methods; Optics; Organ; pain patient; Painless; Patients; Pharmaceutical Preparations; Physiologic pulse; Pigmentation physiologic function; Pigments; pilot trial; Pre-Clinical Model; predictive marker; Primary Neoplasm; Prognostic Marker; prototype; Public Health; public health relevance; Radiation; Recurrence; Resistance; Safety; signal processing; Signal Transduction; Site; Skin; Spectrum Analysis; Speed; System; Techniques; Technology; Testing; theranostics; Therapeutic; therapeutic evaluation; Time; Tissues; Treatment Efficacy; tumor; Ultrasonic Transducer; ","In vivo real time detection of circulating melanoma cells","131164","BMIT","Biomedical Imaging Technology Study Section ","","","10","230375","107284","337659",""
"9669081","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:29824\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","14894485; ","ALVAREZ, SOPHIE ;","","","","Address; Affect; Affinity Chromatography; analytical tool; Applications Grants; base; Bioinformatics; Biological Assay; biomarker identification; Biotechnology; Blood; Breast Cancer cell line; cancer therapy; Cell Line; Chemistry; Complex; Computer software; computing resources; cost effective; Data; Development; DNA-protein crosslink; Drug Delivery Systems; Drug Targeting; Encapsulated; Ensure; Equipment; experience; Experimental Designs; experimental study; Genetic; Goals; Human; Immunoprecipitation; Infrastructure; instrumentation; Knock-out; Label; Link; Liquid Chromatography; Mantle Cell Lymphoma; Mass Spectrum Analysis; Mediating; metabolomics; Methods; Molecular Target; Monitor; mutant; Nanostructures; Nebraska; Peptides; Pharmaceutical Preparations; Pharmacotherapy; Phenotype; Phosphopeptides; Phosphorylation; Phosphorylation Site; Plasma; Post-Translational Protein Processing; Preparation; Procedures; Process; protein protein interaction; Proteins; Proteome; Proteomics; Reagent; Regulation; Regulatory Pathway; repaired; Research; Research Personnel; response; Running; Sampling; screening; Services; Signal Pathway; Signal Transduction; Site; skills; Spectrometry, Mass, Electrospray Ionization; STAT3 gene; Stimulus; student training; Students; tandem mass spectrometry; targeted treatment; Technology; Therapeutic Intervention; therapeutic target; titanium dioxide; tool; TRAF6 gene; U937 Cells; Ubiquitination; Universities; Validation; Wood material; ","Mass Spectrometry Core","121316","ZGM1","Special Emphasis Panel ","8785","","02","29824","0","","29824"
"9669087","P20","GM","5","N","04/23/2019","03/01/2019","02/29/2020","","P20GM121316","","PAR-16-415","5P20GM121316-02","NIGMS:279075\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","OMAHA","UNITED STATES","","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","","10793813; ","WOODS, NICHOLAS TAYLOR;","","","","Address; Affect; Antibodies; Biological Assay; BRCA1 gene; Breast; Breast Cancer Cell; Breast Cancer cell line; Breast Cancer Model; C-terminal; cancer cell; Cell Cycle; Cells; CHEK1 gene; chemotherapy; Chromatin; Cisplatin; Clinical; colon cancer cell line; Complement; Complex; CRISPR/Cas technology; crosslink; Crosslinker; Development; DNA Binding; DNA Damage; DNA Interstrand Crosslinking; DNA Repair; DNA Repair Gene; DNA replication fork; Event; experimental study; Fanconi Anemia pathway; Fanconi anemia protein; Fanconi's Anemia; Fibroblasts; Gamma-H2AX; Growth; HCT116 Cells; high throughput screening; homologous recombination; Human; Impairment; improved; in vivo; in vivo imaging; inhibitor/antagonist; knock-down; Knock-out; Lead; Lesion; malignant breast neoplasm; Malignant Neoplasms; Mass Spectrum Analysis; Mediating; Melphalan; Mitomycins; Molecular Target; mutant; Nebraska; Neoplasm Metastasis; novel; orthotopic breast cancer; overexpression; Patients; phosphoproteomics; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphorylation Site; prevent; Process; Protein Dephosphorylation; Proteins; Proteome; Recovery; Recycling; Regulation; Reporting; Repression; Research; research and development; Resistance; Resolution; Resources; response; RNA Polymerase II; Role; S Phase; Site; small molecule inhibitor; Specificity; Therapeutic; trait; tumor; virtual; Western Blotting; Xenograft Model; ","CTDP1 Regulates FANCI and the Response to DNA Interstrand Crosslinks","121316","ZGM1","Special Emphasis Panel ","8790","","02","183000","96075","","279075"
"9670738","R01","CA","5","N","04/22/2019","04/01/2019","03/31/2020","393","R01CA067007","SCHOOLS OF MEDICINE","PA-16-160","5R01CA067007-24","NCI:363063\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","COLUMBUS","UNITED STATES","GENETICS","03","832127323","US","6218701","OHIO STATE UNIVERSITY","OH","432101016","PROJECT NARRATIVE More than 700 unique genetic alterations of the human mismatch repair (MMR) genes have been reported in families susceptible to LS/HNPCC (http://www.hgmd.cf.ac.uk), of which 20-75% are missense alterations with unknown functional consequences. This proposal will develop and utilize innovative single molecule imaging and analytical methods capable of visualizing and quantitatively examining the ensemble human MMR. These studies will provide a platform for understanding the detailed function(s) of the core MMR components in excision repair, damage signaling, drug resistance and tumorigenesis","1925381; ","FISHEL, RICHARD ;","OKANO, PAUL","04/01/1995","03/31/2022","Affect; analytical method; Biology; biophysical properties; carcinogenesis; Cells; Chromatin; Closure by clamp; Colorectal; Coupled; Defect; Distant; DNA; DNA biosynthesis; DNA Damage; DNA replication fork; DNA Sequence; DNA strand break; Drug resistance; Endometrial; endonuclease; Event; Excision; Excision Repair; Family; gene repair; Genes; Genetic Recombination; Goals; Grant; Hereditary Nonpolyposis Colorectal Neoplasms; histone modification; Human; Image; imaging modality; imaging system; In Vitro; in vivo; Individual; innovation; Lead; Lesion; Light; Malignant Neoplasms; Mechanics; Mismatch Repair; Missense Mutation; Modification; molecular imaging; Motion; Mutation; Nature; Nucleosomes; Nucleotides; Ovarian; Pharmaceutical Preparations; Phenotype; Physiological; Polymerase; Process; protein function; Proteins; PWWP Domain; Reaction; reconstitution; Repair Complex; repaired; Reporting; Resistance; response; Role; S Phase; Scanning; sensor; Signal Transduction; single molecule; Slide; Stomach; Technology; Therapeutic; Time; TREX1 gene; tumor; tumorigenesis; Urologic Neoplasms; Visual; Work; ","Mismatch Repair and Carcinogenesis","067007","MGB","Molecular Genetics B Study Section ","","","24","236348","126715","363063",""
"9672569","P01","HL","5","N","04/26/2019","04/01/2019","03/31/2020","","P01HL136267","","PAR-13-316","5P01HL136267-03","NHLBI:482658\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BIRMINGHAM","UNITED STATES","","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","PROJECT 1 NARRATIVE  Hypertension remains the major risk factor for a huge number of cardiovascular diseases including chronic kidney disease and stroke. Much of this problem is due to the so-called ?Western? diet rich in salt, which expands the scope of the problem. Disruption of daily rhythms increase the risk of cardiovascular and metabolic disease, for example, many cardiovascular events occur more frequently at specific times of day. Furthermore, many cardiovascular risk factors are different between men and women. Studies in the current proposal will elucidate the mechanisms responsible for defects in salt handling in clinically relevant animal models and allow us to learn more about time of day and sex differences that could lead to the development of novel treatment regimens.","1869893; ","POLLOCK, DAVID M;","MARIC-BILKAN, CHRISTINE","","","Acute; Animal Model; Animals; ARNTL gene; Attenuated; attenuation; Blood Circulation; Blood Pressure; Blood Vessels; Cardiovascular Diseases; cardiovascular disorder risk; cardiovascular risk factor; Cardiovascular system; Cell Nucleus; Cells; Chronic; Chronic Kidney Failure; circadian; circadian regulation; Circadian Rhythms; clinically relevant; cryptochrome; Data; Defect; design; Development; dietary salt; Disease; Duct (organ) structure; Endothelin; Endothelin-1; Endothelium; Equilibrium; Estrogens; Event; Excretory function; Fasting; feeding; Female; Frequencies; Genes; Genetic; Genetic Transcription; Goals; Gonadal Steroid Hormones; hemodynamics; high salt diet; Homeostasis; Hypertension; In Vitro; insight; Kidney; Knock-out; Knockout Mice; Lead; Learning; male; Mediating; men; Metabolic; Metabolic Diseases; molecular clock; Natriuresis; novel; novel therapeutic intervention; Output; Pathway interactions; Periodicity; Peripheral; Phase; Physiological Processes; Play; Rattus; receptor; Receptor Activation; receptor function; Regulation; Renal function; Research Personnel; response; Risk; Risk Factors; Role; salt intake; Secondary to; Sex Characteristics; Signal Pathway; Sleep; Sodium; Sodium Chloride; Specificity; Stroke; System; Testing; Testosterone; Time; transcription factor; Translations; Treatment Protocols; Tubular formation; Variant; Vascular Endothelium; vasoconstriction; Water; western diet; Western World; Woman; ","Circadian control of sodium excretion","136267","HLBP","Heart, Lung, and Blood Initial Review Group ","8215","","03","353546","129112","","482658"
"9673214","R01","HL","5","N","04/27/2019","04/01/2019","03/31/2020","838","R01HL132523","SCHOOLS OF MEDICINE","PA-13-302","5R01HL132523-04","NHLBI:1376435\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","TUCSON","UNITED STATES","PEDIATRICS","03","806345617","US","490201","UNIVERSITY OF ARIZONA","AZ","857210158","PUBLIC HEALTH RELEVANCE: This study provides a unique opportunity to investigate, in a single non-selected population followed from birth, risk factors for asthma and chronic obstructive lung disease (COPD), the two leading causes of morbidity and mortality in US adults. Subjects in the Tucson Children's Respiratory Study are now in their mid-thirties, a critical age during which early symptoms and functional manifestations of COPD first occur. We will identify the early life factors that predispose for the development of these conditions, specifically testing the hypothesis that altered responses to respiratory viruses are major determinants of the early origins of asthma and COPD.","8224143; 1882730 (contact); 1867481; ","GUERRA, STEFANO ; MARTINEZ, FERNANDO D (contact); WRIGHT, ANNE L.;","NOEL, PATRICIA","06/01/2016","03/31/2020","Address; Adult; Adult asthma; Affect; Age; age related; Age-Years; Airway Obstruction; American; Asthma; Biogenesis; Birth; Breast Feeding; Cause of Death; Cells; Child; Childhood; Childhood Asthma; Chronic; Chronic Bronchitis; Chronic Obstructive Airway Disease; Clinical; clinically significant; cohort; Cohort Studies; Country; Data; Development; Diagnosis; Disease; early childhood; early life exposure; Enrollment; Environmental Risk Factor; Epithelial Cells; Event; Exposure to; Gene Expression; Gene Expression Profile; Health Care Costs; Hospitalization; Human; In Vitro; Infection; Integration Host Factors; Life; Longitudinal Studies; Molecular; Morbidity - disease rate; mortality; Natural History; Newborn Infant; Nose; Nursery Schools; Outcome; Participant; Pathway interactions; Patients; Peripheral Blood Mononuclear Cell; Persons; Phase; Phenotype; Plant Roots; Pneumonia; Population; pre-clinical; Predisposing Factor; Prevention strategy; Primary Prevention; prospective; public health priorities; public health relevance; Recording of previous events; respiratory; Respiratory physiology; Respiratory syncytial virus; respiratory virus; response; Rhinovirus; Risk; Risk Factors; Role; Smoke; Smoker; Smoking; Sputum; Symptoms; Testing; Tissue-Specific Gene Expression; Wheezing; ","Early Origins of Chronic Airflow Limitation: Outcomes Into the 4th Decade of Life","132523","ZRG1","Special Emphasis Panel ","","","04","896700","479735","1376435",""
"9675232","U01","CA","5","N","04/24/2019","04/01/2019","03/31/2020","394","U01CA152637","","RFA-CA-14-015","5U01CA152637-09","NCI:779890\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","SEATTLE","UNITED STATES","","07","078200995","US","861001","FRED HUTCHINSON CANCER RESEARCH CENTER","WA","981094433","PUBLIC HEALTH RELEVANCE: Successful early detection of breast, colorectal, and ovary cancers remain persistent concerns. Through our current EDRN funding our multidisciplinary team has identified promising sets of early detection biomarkers for each of these cancers and here we propose Phase 2 and Phase 3 validation studies for clearly defined clinical applications. In addition, we propose to bring several key resources to EDRN with respect to both biospecimens and scientific expertise.","9987726; 3168785; 6603731 (contact); ","DRESCHER, CHARLES ; LAMPE, PAUL D; LI, CHRISTOPHER I (contact);","GHOSH-JANJIGIAN, SHARMISTHA","08/16/2010","03/31/2021","Area; arm; Autoantibodies; Biological Markers; biomarker development; biomarker discovery; biomarker validation; Biometry; Blood; Breast; Breast Cancer Early Detection; CA-125 Antigen; Cancer Biology; cancer biomarkers; cancer risk; cancer type; candidate marker; cardiovascular health; Clinical; clinical application; Collaborations; Colonoscopy; Colorectal; Colorectal Cancer; Data; Data Analyses; design; early detection biomarkers; Early Detection Research Network; Early Diagnosis; Epidemiology; Epitopes; Funding; Goals; improved; Interdisciplinary Study; laboratory development; Lead; Leadership; malignant breast neoplasm; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Malignant Neoplasms; Mammographic screening; Mammography; Methodology; Molecular Conformation; Monitor; mortality; multidisciplinary; multimodality; novel; novel marker; oncology; Ovary; Paper; Patients; Performance; Phase; phase 2 study; phase 3 study; phase 3 testing; population based; Positioning Attribute; pre-clinical; Productivity; Public Health; public health relevance; Reporting; repository; Research Design; Research Personnel; Resources; Sampling; screening; Screening for cancer; Screening for Ovarian Cancer; Series; Serous; Site Visit; success; Testing; Tissue Sample; TP53 gene; Tumor Antigens; Tumor Tissue; Ultrasonography; United Kingdom; Validation; validation studies; WFDC2 gene; Woman; Women's Health; Work; ","Breast, Colorectal, and Ovary Cancer Clinical Validation Center","152637","ZCA1","Special Emphasis Panel ","","","09","583624","401594","779890",""
"9675351","UG3","NS","5","N","04/25/2019","04/01/2019","03/31/2020","853","UG3NS106941","SCHOOLS OF MEDICINE","RFA-NS-17-023","5UG3NS106941-02","NINDS:366393\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","WASHINGTON","UNITED STATES","NEUROSCIENCES","98","049515844","US","2869001","GEORGETOWN UNIVERSITY","DC","200570001","PROJECT NARRATIVE  The purpose of this proposal is to validate pathophysiological changes to synapses and neuronal circuitry after traumatic brain injury (TBI) as a marker that aligns closely with assessments of neurobehavior. We will use a combination of synapse morphology, receptor biology, and electrophysiology to show that changes to synaptic integrity and neural networks can predict behavioral outcomes in mice. We will also adapt a novel functional MRI (fMRI) analysis technique called Hcorr for TBI research. Hcorr is a local regional heterogeneity analysis that use fMRI activation patterns to infer neuronal selectivity, which may have the potential to serve as an indirect measure of synaptic function.  Synaptic changes have been extensively reported after experimental TBI, with synapse loss occurring in multiple different animal models of mild, moderate and severe TBI including controlled cortical impact (CCI) and fluid percussion injury (FPI), and mild closed head impact. Thus the loss of synapses appears to be a common event, regardless of injury type and injury severity. Despite this common pathophysiology, there are clear differences between injury models in regard to acute and chronic synaptic integrity. We have selected an assessment battery consisting of validated techniques to measure synapse integrity, biology, and function. We will use regression analysis to determine the techniques with the best predictive validity for cognitive function after TBI, and assess if Hcorr can be used to predict these outcomes from non-invasive fMRI scans.  We will examine synaptic responses in three different TBI paradigms: 1) a single mild TBI that presents with transient synapse loss, no axonal injury, and no cognitive impairments; 2) repeat mTBI (30 mTBI) that presents with functional synapse changes including altered brainwave patterns, impaired hippocampal long term potentiation (LTP), and chronic behavioral deficits in learning and memory; 3) CCI that presents with widespread synapse loss, neuronal cell death, inflammation, and traumatic axonal injury. For each injury paradigm and their respective controls we will study acute (1d and 7d) and chronic (1m and 3m) timepoints to determine the continuum of synapse responses to each type of injury.  We have established a multidisciplinary team based in the Washington DC area that will work independently using a blind study design, to study synaptic changes and recovery after TBI. The TBI injuries will occur in the Burns Lab (Georgetown). Synaptic counts, morphology, and architecture will be studied in the Dickstein Lab (USUHS). Behavior, synaptic biochemistry and molecular biology will be conducted in the Burns Lab (Georgetown). Electrophysiology will be conducted in the Wu Lab (Georgetown). MRI will be conducted in the Dardzinski Lab (USUHS), and Hcorr analysis by the Jiang Lab (Georgetown).  Internal and external assessments on whether go/no-go targets have been achieved will be made according to the TOP-NT guidelines. If transition milestones are achieved, the UH3 phase will focus on external replication and validation of the information, and expand to include animal models that exist within the TOP-NT consortium. Georgetown and USUHS Investigators will work with the consortium investigators to confirm that their experimental paradigms align with the protocols established in the UG3 phase, and establish data sharing activities with the consortium.","8234739; ","BURNS, MARK P;","BELLGOWAN, PATRICK S F","04/15/2018","03/31/2020","Acute; Adult; Aging; Animal Model; animal tissue; Animals; Architecture; Area; Award; axon injury; base; Behavior; Behavioral; behavioral outcome; Biochemistry; Biology; blind; Brain Contusions; Burn injury; Chronic; Clinical; cognitive ability; cognitive function; controlled cortical impact; Data Analyses; Data Collection; District of Columbia; Electrophysiology (science); Ensure; Event; fluid percussion injury; Functional disorder; Functional Magnetic Resonance Imaging; functional MRI scan; Goals; Guidelines; head impact; Heterogeneity; Hippocampus (Brain); HIV Seropositivity; IACUC; Image; Impaired cognition; Impairment; improved; Individual Differences; Inflammation; Injury; Intervention; Learning; Long-Term Potentiation; Magnetic Resonance Imaging; Measures; Memory; Methods; mild traumatic brain injury; Modeling; Molecular Biology; Morphology; multidisciplinary; Mus; neural network; neurobehavior; neuroinflammation; neuron loss; neuronal circuitry; Neuronal Dysfunction; Neurons; novel; Outcome; outcome prediction; Patients; Pattern; Phase; preference; Procedures; Protocols documentation; receptor; Recovery; Regression Analysis; Reporting; Research; Research Design; Research Personnel; response; Severities; sharing data; Statistical Data Interpretation; Synapses; synaptic function; tau aggregation; tau-1; Techniques; Technology; TimeLine; Traumatic Brain Injury; Traumatic Brain Injury recovery; Validation; Work; ","Detecting the disruption and recovery of synaptic connectivity after TBI","106941","ZNS1","Special Emphasis Panel ","","","02","256387","110006","366393",""
"9676318","P30","ES","5","N","04/26/2019","04/01/2019","03/31/2020","","P30ES027792","","RFA-ES-16-001","5P30ES027792-03","NIEHS:197101\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","CHICAGO","UNITED STATES","","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","","6131243; ","CHIU, BRIAN C-H;","","","","Address; Air; ambient air pollution; Area; arm; base; Basic Science; biobank; Biological; Biological Assay; Biological Markers; Cancer Center; Chicago; Clinical; Clinical and Translational Science Awards; Clinical Research; Collaborations; Collection; Communities; Community Outreach; Consent; Core Facility; Data; Data Collection; data management; design; Detection; Development; Diet; Disease; disorder prevention; Dust; Early Diagnosis; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Health; environmental justice; epidemiology study; Equipment; Ethics; ethnic health disparity; experience; Exposure to; Focus Groups; Food; fundamental research; Health; health data; health disparity; health science research; Health Sciences; human biological material; Human Resources; human subject; Illinois; improved; Indoor Air Pollution; Information Dissemination; Infrastructure; innovation; Institution; Institutional Review Boards; Integrative Medicine; Intervention; Knowledge; Leadership; Measurement; member; Metals; Methods; Mission; mobile computing; Modeling; Molecular; Outcome; Participant; patient oriented; Patient Recruitments; Pilot Projects; Population; Preparation; Prevention; programs; Public Health; quality assurance; Questionnaires; racial and ethnic; recruit; Research; Research Design; Research Personnel; Research Project Grants; Research Training; Resources; sample collection; Sampling; Services; Source; Specimen Handling; statistical service; statistics; Study models; study population; targeted biomarker; Techniques; Technology; tool; Training; Translating; translational health science; Translational Research; Universities; Water; Work; ","CACHET: Integrative Health Sciences Facility Core","027792","ZES1","Special Emphasis Panel ","7103","","03","162305","34796","","197101"
"9676319","P30","ES","5","N","04/26/2019","04/01/2019","03/31/2020","","P30ES027792","","RFA-ES-16-001","5P30ES027792-03","NIEHS:52597\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","CHICAGO","UNITED STATES","","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","","10716053; ","GILBERT, JACK ANTHONY;","","","","Anaerobic Bacteria; analytical method; Androgens; Animals; base; Biological Assay; Biological Markers; bisphenol A; Carbazoles; Chicago; Collaborations; Core Facility; Coupled; design; Detection; Development; dibenzofuran; Dinoprostone; discount; DNA Adducts; DNA Markers; Endocrine Disruptors; Environment; environmental chemical; Environmental Impact; Estrogens; experience; Exposure to; Flame Retardants; Focus Groups; Food; Gas Chromatography; Health; Heavy Metals; High Pressure Liquid Chromatography; Human; Human Microbiome; Illinois; Individual; Inductively Coupled Plasma Mass Spectrometry; inflammatory marker; Isoprostanes; Laboratories; Lipid Peroxidation; Liquid Chromatography; liquid chromatography mass spectrometry; Liquid substance; Mass Fragmentography; Measurement; Measures; member; metabolomics; Metagenomics; Metals; metatranscriptomics; Methods; microbial; microbiome; Needs Assessment; next generation sequencing; Nose; Oral cavity; Organic Chemicals; organochlorine pesticide; oxidation; Oxidative Stress; oxidized lipid; Performance; Pesticides; Physiological; pollutant; Polychlorinated Biphenyls; pressure; Procedures; Prostaglandin D2; Prostaglandins; Proteomics; Research; Research Personnel; Resources; response; Role; Sampling; Serum; Services; Skin; Soil; Source; Specimen; Stimulus; tandem mass spectrometry; Technology; Tissues; Toxic Environmental Substances; toxicant; Toxin; transcriptomics; Universities; urinary; Urine; Validation; Water; ","CACHET: Biomarkers Core","027792","ZES1","Special Emphasis Panel ","7104","","03","37806","14791","","52597"
"9676375","F30","HL","5","N","04/20/2019","04/21/2019","10/20/2019","837","F30HL137263","GRADUATE SCHOOLS","PA-16-305","5F30HL137263-03","NHLBI:19406\","TRAINING, INDIVIDUAL","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LOS ANGELES","UNITED STATES","CHEMISTRY","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","PROJECT NARRATIVE The FHOD family of formins is essential for normal immune, muscle, and heart function, and contributes to cancer invasion. The proposed research will reveal the role of the FHOD tail in regulating its activity, with substantial implications for diseases such as cardiomyopathies, in which FHOD activity is altered.","11905241; ","PATEL, AANAND ;","MEADOWS, TAWANNA","04/21/2017","10/20/2019","Actins; Adhesions; Affinity; Alternative Splicing; Animal Model; Area; base; Binding; Biochemical; Biological; Biological Assay; Biological Models; Biological Process; Bundling; C-terminal; cancer cell; Cardiac; Cardiomyopathies; cell motility; cell type; Cells; Cytoskeleton; Data Set; Defect; Development; Disease; Drosophila genus; experimental study; Family member; FHOD3 gene; Filament; Fluorescence Microscopy; fly; Gene Proteins; Genetic; Heart Diseases; heart function; Hemocytes; imaginal disc; immune function; In Vitro; in vivo; insight; Knock-out; macrophage; Malignant Neoplasms; Mammals; Measures; Microfilaments; Montana; Morphology; Muscle; Muscle function; Myocardium; Myofibrils; Myopathy; Neuroglia; Pattern; Phenotype; Play; promoter; Protein Family; Protein Isoforms; Protein Splicing; Proteins; Pyrenes; Regulation; Research; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Splicing; Role; Sarcomeres; Side; skeletal; Skeletal Muscle; Stress Fibers; Striated Muscles; Structure; System; Tail; Testing; Time; Tissues; transcriptome sequencing; Variant; Work; ","Regulation of the Drosophila Formin FHOD by Alternative Splicing","137263","ZRG1","Special Emphasis Panel ","","","03","19406","","19406",""
"9677677","UH3","NS","5","N","04/26/2019","04/01/2019","03/31/2020","853","UH3NS100553","SCHOOLS OF MEDICINE","RFA-NS-16-010","5UH3NS100553-03","NCCAM:1165696\NINDS:586928\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","BIRMINGHAM","UNITED STATES","NEUROLOGY","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","PROJECT NARRATIVE Deep brain stimulation (DBS) is an established therapy for Parkinson's disease, yet outcomes vary significantly in individuals and across clinical trials. The purpose of this research is to use minimally invasive, patient- specific cortical physiology elicited by DBS to guide the use of emerging segmented (?directional?) DBS electrode technologies. Our results will provide novel methods to predict and personally optimize efficient implementation of current steering to improve the efficacy, safety, and tolerability of DBS therapy for advanced Parkinson's disease.","3105390; ","WALKER, HARRISON CARROLL;","LANGHALS, NICK B","09/30/2016","03/31/2022","Adverse effects; Anatomy; Animal Model; Axon; base; Behavior; Behavioral; Biological Markers; Bradykinesia; candidate marker; Clinical; Clinical Trials; Corticobulbar Tracts; Cross-Over Studies; Deep Brain Stimulation; design; Devices; Disease; Dose; Double-Blind Method; Eastern Cooperative Oncology Group; effective therapy; Effectiveness; Electrocorticogram; Electrodes; Electroencephalography; Electrophysiology (science); Event-Related Potentials; Foundations; Gait; Goals; Hour; Human; improved; Individual; individual patient; innovation; insight; Knowledge; Lead; Life; Link; Measures; Methods; minimally invasive; Morphology; Motor; Motor Pathways; Movement; Movement Disorders; Muscle; Muscle Contraction; Neurology; Neurons; neuroregulation; next generation; novel; Operative Surgical Procedures; Outcome; Parkinson Disease; Participant; Pathway interactions; Patients; Pattern; Physiologic pulse; Physiology; Population; Postoperative Period; predictive marker; Process; Psychiatry; Quality of life; Randomized; Reporting; Research; Safety; Shapes; Site; Smooth Muscle; Speech; Stimulus; success; symptomatic improvement; Technology; Testing; Therapeutic Trials; Time; Treatment Efficacy; Tremor; Visit; Work; ","Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson's Disease","100553","ZNS1","Special Emphasis Panel ","","","03","1356736","395888","1752624",""
"9686381","P30","ES","2","N","04/26/2019","04/01/2019","03/31/2020","","P30ES000002","","RFA-ES-18-003","2P30ES000002-56","NIEHS:193006\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BOSTON","UNITED STATES","","07","149617367","US","3212904","HARVARD SCHOOL OF PUBLIC HEALTH","MA","021156028","","9467667; ","ADAMKIEWICZ, GARY ;","","","","Address; Adopted; Air Pollutants; analytical tool; Area; base; Bioinformatics; Boston; Censuses; Childhood; Collaborations; Communities; Community Actions; community center; community organizations; Community Participation; Core Facility; Data; Data Analytics; data visualization; Disasters; Educational workshop; Effectiveness; Environmental Exposure; Environmental Health; environmental justice; Environmental Risk Factor; Event; expectation; experience; Exposure to; Facility Accesses; Faculty; Festival; Fostering; Funding; Funding Mechanisms; Geography; Goals; Grant; Health; health disparity; Health education; health equity; Health Professional; Health Sciences; Human; Incubators; Laws; Leadership; Massachusetts; Measurable; Measures; medical specialties; meetings; member; Metal exposure; Mission; Modeling; National Institute of Environmental Health Sciences; Neighborhoods; North Carolina; novel strategies; Organic Chemicals; outreach; Particulate; Pilot Projects; Policies; Pollution; Population; programs; prospective; Public Health; Recovery; Regulation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Schools; Science; Seeds; Services; socioeconomics; Statistical Data Interpretation; statistics; stressor; Structure; synergism; Translating; Translations; Universities; Vision; Work; ","Community Engagement Core","000002","EHS","Environmental Health Sciences Review Committee ","5376","","56","121007","71999","","193006"
"9689313","R01","HL","5","N","04/26/2019","04/01/2019","03/31/2020","837","R01HL140301","SCHOOLS OF ARTS AND SCIENCES","PA-16-160","5R01HL140301-02","NHLBI:363273\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","FORT COLLINS","UNITED STATES","CHEMISTRY","04","785979618","US","1725201","COLORADO STATE UNIVERSITY","CO","805232002","NARRATIVE: The current paradigm of creating materials for non-thrombogenic medical devices focuses on understanding and disrupting the biochemical interactions that occur due to biological processes at blood-material interfaces. These challenges are a fundamental concern, as they lead to major complications in patient care and morbidity in the critically ill patient population. The release of nitric oxide (NO) at the device interface has been shown to prevent clotting without the deleterious side effects of systemic anticoagulants, yet the use of current NO materials is limited to acute applications due finite loading capacities of the materials. This project involves using novel heterogeneous catalysts that can extend the therapeutic levels of NO for longer periods without introduction of undesirable properties. The new catalysts will be applied as intravenous catheter coatings and their performance evaluated in both preclinical models for blood compatibility, toxicity and in vivo performance. The work will result in a new approach for developing more effective blood contacting catheters with longer device lifetimes that are able to be manufactured with common techniques, thus making their translation to a product easier. As such, the research will result in significant advances in the design of new materials and provide the system necessary for application as clinically relevant devices. As a result, patient care will increase while enabling a substantial decrease in healthcare expenditures.","10133513; 10148297 (contact); ","HANDA, HITESH ; REYNOLDS, MELISSA M (contact);","LEE, ALBERT","05/01/2018","03/31/2022","Achievement; Acute; Address; Adverse effects; Animal Model; Anticoagulants; base; Biochemical; Biological; Biological Process; Blood; Blood Platelets; Blood Pressure; catalyst; Catheters; Cell Culture Techniques; Cellular Assay; Cessation of life; chemical property; Chronic; clinical application; clinical practice; clinically relevant; clinically significant; Coagulation Process; Conscious; Copper; Critical Illness; Custom; design; Devices; dosage; Equipment Malfunction; Evaluation; experimental study; Failure; Functional disorder; Grant; Half-Life; Health Expenditures; Healthcare; hemocompatibility; Hemostatic function; Heparin; Hepatocyte; Human; implantable device; improved; In Vitro; in vitro Assay; in vitro Bioassay; in vitro Model; in vivo; Inductively Coupled Plasma Mass Spectrometry; Infection; Inflammation; Intravenous; Ions; Lead; Length; Measures; mechanical properties; Mechanics; Medical Device; Metals; Methemoglobin; Modeling; Modification; Morbidity - disease rate; Nature; Nitric Oxide; Nitric Oxide Donors; novel; novel strategies; Oryctolagus cuniculus; Patient Care; patient population; Patients; Performance; Pharmacotherapy; Physiological; Platelet Activation; platelet function; Polymers; Polyurethanes; Pre-Clinical Model; prevent; Production; Property; prototype; Research; S-Nitrosothiols; Safety; Silicone Elastomers; Source; Spectrum Analysis; standard of care; Stream; Surface; System; Techniques; Technology; Testing; Therapeutic; Therapeutic Agents; therapeutic target; Thrombosis; Thrombus; Time; Tissues; Toxic effect; Translations; Work; ","Metal organic framework-based antithrombotic surfaces","140301","BTSS","Bioengineering, Technology and Surgical Sciences Study Section ","","","02","293166","70107","363273",""
"9697676","D43","TW","5","N","04/24/2019","04/01/2019","01/31/2020","989","D43TW009607","SCHOOLS OF MEDICINE","PAR-16-279","5D43TW009607-07","FIC:300208\","OTHER RESEARCH-RELATED","2019","FOGARTY INTERNATIONAL CENTER","","NEW HAVEN","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","03","043207562","US","9420201","YALE UNIVERSITY","CT","065208327","Narrative The proposed Yale School of Public Health?University of California Berkeley?Makerere University Pulmonary Complications of AIDS Research Training (PART) Program will train Ugandan investigators in clinical, translational, and implementation research on TB and other pulmonary complications of HIV. This will strengthen Makerere's capacity to conduct high quality, innovative, locally relevant HIV/AIDS research.","8739223 (contact); 9714908; 1871890; ","DAVIS, JOHN LUCIAN (contact); KATAMBA, ACHILLES ; REINGOLD, ARTHUR L;","BANSAL, GEETHA PARTHASARATHY","08/01/2013","01/31/2023","Acquired Immunodeficiency Syndrome; Advisory Committees; AIDS/HIV problem; Area; base; California; career; career development; Collaborations; college; Country; Degree program; design; Doctor's Degree; Educational workshop; Enrollment; experience; Faculty; Fellowship; Funding; Health Sciences; HIV; Human Resources; implementation research; implementation science; improved; Individual; Institution; International; laboratory experience; Laboratory Technicians; Lung; Lung diseases; Medical; meetings; Mentors; next generation; Nongovernmental Organizations; Outcome; patient oriented research; Postdoctoral Fellow; pre-doctoral; programs; Public Health; Public Health Schools; Recording of previous events; Research; Research Personnel; Research Support; Research Training; Scientist; Specialist; Thinking; Training; Training Programs; Translational Research; Uganda; Universities; Visit; ","TB and Other Pulmonary Complications of AIDS Research Training Program","009607","ZRG1","Special Emphasis Panel ","","","07","295448","4760","300208",""
"9701959","P30","DK","5","N","04/25/2019","04/01/2019","03/31/2020","847","P30DK036836","","RFA-DK-16-020","5P30DK036836-33","NIDDK:1646953\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","07","071723084","US","2133701","JOSLIN DIABETES CENTER","MA","022155306","PROJECT NARRATIVE For the last 30 years, the Joslin DRC has catalyzed the diabetes research effort at Joslin, Harvard and Boston research institutions. The contributions of its Cores, Pilot and Feasibility Program, and Enrichment Program can be measured by their heavy use involving over 30 laboratories at Joslin, and 40 other laboratories within the Boston and Massachusetts area. The product has been groundbreaking research that has generated many new ideas regarding the pathogenesis of diabetes and its complications. The results have also translated into clinical research and treatments, including FDA-approved therapeutics.","1892882; ","KING, GEORGE L;","HYDE, JAMES F","02/15/1997","03/31/2022","animal facility; Animal Model; Animals; Area; base; Basic Science; biobank; Bioenergetics; Bioinformatics; Biological; Biological Assay; Boston; Cell model; Cell Separation; Cells; cellular imaging; Cellular Morphology; Center for Translational Science Activities; Clinical; Clinical Research; Clinical Treatment; cohort; Collaborations; Communities; Complement; Computational Biology; Computerized Medical Record; Coupled; CRISPR/Cas technology; Cytometry; Data Analyses; design; Development; Diabetes Mellitus; diabetic; digital; DNA Microarray Chip; Epidemic; Exercise Physiology; FDA approved; Floor; Flow Cytometry; Fostering; Funding; Future; Genes; Genetic; genome editing; Genomics; Genotype; Germ-Free; Grant; Growth; gut microbiome; Human Resources; Imaging Device; improved; induced pluripotent stem cell; innovation; Institution; International; Investments; Laboratories; Laboratory Research; Lead; Link; Massachusetts; Measures; Medical; medical schools; metabolic abnormality assessment; Metabolic Diseases; Metabolism; metabolomics; Microscopy; Modeling; molecular phenotype; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; new technology; Obesity; Pathogenesis; Patients; Physiology; Population; Postdoctoral Fellow; Procedures; programs; Proteomics; recruit; repository; Research; research facility; Research Infrastructure; Research Personnel; research study; Resources; Rodent Model; Role; Sampling; Series; Services; Source; Students; Study models; Subfamily lentivirinae; success; symposium; Technology; Therapeutic; Translating; Translational Research; translational study; United States National Institutes of Health; Universities; ","Diabetes Research Center","036836","ZDK1","Special Emphasis Panel ","","","33","975971","670982","1646953",""
"9710564","P30","AG","1","N","04/26/2019","04/01/2019","03/31/2020","","P30AG062422","","RFA-AG-19-001","1P30AG062422-01","NIA:543544\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","6858573; ","KRAMER, JOEL H;","","","","accurate diagnosis; Age; Age of Onset; Aging; Amyloid; Area; Autopsy; Biological Markers; Biopsy; Brain; Caregivers; caregiving research; Chinese American; Chinese People; Clinical; Clinical assessments; Clinical Data; clinical phenotype; Clinical Research; Clinical Trials; Cognition; Cognitive; cognitive function; cohort; Collection; Communities; Consent; Creutzfeldt-Jakob Syndrome; data acquisition; Data Set; demented; Dementia; demographics; design; Development; Diagnostic; Differential Diagnosis; Dimensions; Disease; DNA; Early Diagnosis; education research; Emotional; Emotions; Enrollment; Ensure; Event; Evolution; Exposure to; Family; Frontotemporal Dementia; Funding; Genetic; Goals; Grant; Health; Heterogeneity; Human Resources; Image; improved; Individual; innovation; International; Intervention; K-Series Research Career Programs; Latino; Leadership; Life Style; Magnetic Resonance Imaging; Measures; member; Methods; Mission; Molecular; molecular subtypes; Motor; multidisciplinary; Mutation; Nerve Degeneration; Neurodegenerative Disorders; neuroimaging; novel; novel strategies; outreach; outreach program; Participant; Patients; Phenotype; Plasma; Play; Positron-Emission Tomography; Prion Diseases; Prions; programs; psychologic; Publications; ranpirnase; Recording of previous events; recruit; Registries; Research; Research Project Grants; Research Subjects; Research Support; Research Training; Resources; Risk; Risk Factors; RNA; Role; Rotation; Salvelinus; San Francisco; Skin; social; social cognition; Socioeconomic Status; Specialized Center; Tablets; tau Proteins; Training Programs; Underrepresented Groups; underserved minority; Work; ","Core B: Clinical Core","062422","ZAG1","Special Emphasis Panel ","5034","","01","338833","204711","","543544"
"9710565","P30","AG","1","N","04/26/2019","04/01/2019","03/31/2020","","P30AG062422","","RFA-AG-19-001","1P30AG062422-01","NIA:381429\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","7044006; ","RANKIN, KATHERINE P;","","","","Address; Aging; Alzheimer's Disease; analytical method; Architecture; Back; Basic Science; Biological Markers; Biometry; Brain; Clinical; Clinical Research; cohesion; Collection; Complex; Consultations; Creativeness; Custom; Data; Data Analyses; Data Analytics; Data Collection; data integration; data management; Data Quality; Data Set; data submission; Dementia; design; Diagnosis; Differential Diagnosis; Disease; Early Diagnosis; Education; education research; Ensure; Epidemiology; Etiology; experience; Faculty; Foundations; Genetic; genetic signature; Genotype; Goals; healthy aging; Heterogeneity; Human Resources; Image; Imagery; improved; Infrastructure; innovation; insight; Institution; Investigation; Leadership; Link; longitudinal analysis; Mediating; Memory; mild cognitive impairment; Modeling; Molecular; multidisciplinary; Natural History; Nature; neurobehavioral; Neurologic; Neurology; novel strategies; open source; Pathologic; Patients; Pattern; Phenotype; phenotypic biomarker; Positioning Attribute; predictive modeling; Process; programs; proteomic signature; quality assurance; Quality Control; Recommendation; Recording of previous events; Research; Research Design; Research Methodology; Research Personnel; Resource Sharing; Resources; Signs and Symptoms; Solid; Source; Statistical Data Interpretation; Statistical Methods; Statistical Models; statistics; Structure; Support System; support tools; Syndrome; System; Techniques; Technology; Time; tool; Translational Research; United States National Institutes of Health; ","Core C: Data Management and Statistics Core","062422","ZAG1","Special Emphasis Panel ","5035","","01","237774","143655","","381429"
"9715827","IK2","VA","1","N","04/25/2019","04/01/2019","03/31/2020","999","IK2RX002920","","RFA-RX-18-016","1IK2RX002920-01A1","","OTHERS","2019","Veterans Affairs","","SAN DIEGO","UNITED STATES","","52","073358855","US","481156","VA SAN DIEGO HEALTHCARE SYSTEM","CA","921610002","The proposal aims to determine if non-invasive vagus nerve stimulation(nVNS) will alter: 1) the peripheral inflammatory biomarker profile, 2) the neural correlates of change in pain stimuli and 3) PTSD symptom severity and 4) life quality and function in Veterans with PTSD. The planned inflammatory biomarker and neuroimaging results can 1) promote knowledge of inflammatory and neurobiological mechanisms that contribute to pain in PTSD, and 2) advance our ability to provide targeted neuromodulation based interventions that support improved life quality and function for Veterans. These goals are consistent with the VA?s mission to sponsor research examining variables related to pathogenesis, diagnosis, and(ultimately) treatment of neuropsychiatric disorders.","11610828; ","LERMAN, IMANUEL RUVIN;","","04/01/2019","03/31/2024","Afghanistan; Aftercare; Amygdaloid structure; Anxiety; Autonomic nervous system; Aversive Stimulus; base; Biological Markers; Brain; Brain imaging; Brain region; Chronic; chronic pain; Clinical Practice Guideline; combat; Comorbidity; cytokine; daily functioning; Data; Development; Devices; Diagnosis; DSM-V; effective therapy; Effectiveness; FDA approved; follow-up; functional disability; Functional disorder; Functional Magnetic Resonance Imaging; functional outcomes; Generations; Goals; Health; Heart Diseases; hypothalamic-pituitary-adrenal axis; immune activation; Immune System Diseases; improved; improved functioning; indexing; Inflammation; Inflammatory; Insula of Reil; Interleukin-1 beta; Interleukin-6; Intervention; Intervention Studies; Iraq; K-Series Research Career Programs; Knowledge; Longevity; Measures; Mental disorders; Methods; Mission; mortality; Nerve; neural circuit; neural correlate; Neuraxis; neurobiological mechanism; neuroimaging; neuromechanism; neuropsychiatric disorder; neuroregulation; nociceptive response; novel strategies; Outcome; Pain; pain processing; Participant; Pathogenesis; Pathologic; Perception; Peripheral; peripheral blood; Pharmacologic Substance; physical symptom; Physiological; Physiology; post-traumatic stress; Post-Traumatic Stress Disorders; Procedures; Psychotherapy; Quality of life; relating to nervous system; Reporting; Research; Research Training; response; Risk Factors; Scientist; service member; Services; Severities; Signal Transduction; Stimulus; symptomatic improvement; Symptoms; Technology; Time; TNF gene; tool; Treatment Efficacy; vagus nerve stimulation; Veterans; Vietnam; War; Work; World Health Organization Disability Assessment Schedule; ","Vagal nerve stimulation to probe inflammation and brain in posttraumatic stress","002920","RRD8","Career Development Program - Panel I ","","A1","01","","","",""
"9718899","P30","AR","1","N","04/24/2019","04/15/2019","03/31/2020","","P30AR074992","","RFA-AR-19-002","1P30AR074992-01","NIAMS:156625\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","SAINT LOUIS","UNITED STATES","","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","","2477081; ","SILVA, MATTHEW J;","","","","Address; Adherence; Animal Model; animal tissue; base; Biology; Biomechanics; bone; Cartilage; cellular imaging; Communities; contrast enhanced; cost effective; Data; Data Quality; Development; Diagnostic radiologic examination; Dual-Energy X-Ray Absorptiometry; Ensure; Equipment; Evaluation; Exhibits; Fees; Fostering; Fracture; functional outcomes; Funding; Future; Goals; Human Resources; Image; Image Enhancement; imaging approach; in vivo; Individual; instrument; long bone; Manuscripts; Measures; mechanical properties; Mechanics; Medicine; member; Methods; Microscope; Morphology; Muscle; Muscle Tension; Musculoskeletal; musculoskeletal imaging; notch protein; novel strategies; online resource; Outcome; Productivity; programs; Property; Protocols documentation; Publications; Reporting; Research; Research Personnel; Resolution; Resources; response; Roentgen Rays; Saints; Schedule; Services; skeletal disorder; spine bone structure; Structure; submicron; Supervision; Techniques; Tendon structure; Testing; Time; Tissues; Training; Training Programs; Universities; Washington; X-Ray Computed Tomography; ","Musculoskeletal Structure and Strength Core","074992","ZAR1","Special Emphasis Panel ","5347","","01","100000","56625","","156625"
"9718901","P30","AR","1","N","04/24/2019","04/15/2019","03/31/2020","","P30AR074992","","RFA-AR-19-002","1P30AR074992-01","NIAMS:156625\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","SAINT LOUIS","UNITED STATES","","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","","2233236; ","ABU-AMER, YOUSEF ;","","","","Address; Animal Behavior; Animal Model; Animal Testing; Anti-inflammatory; Arthralgia; arthritic pain; Arthritis; arthropathies; Awareness; base; Behavior; Benchmarking; biobank; Biocompatible Materials; Biological; Biological Assay; Biology; Biomechanics; bone; Cells; cohort; Collaborations; Communities; Data; Degenerative polyarthritis; Disease; Disease Management; Disease model; Education and Outreach; Epidemic; Evaluation; Fresh Tissue; Functional disorder; functional outcomes; Funding; Gene Proteins; Goals; Guidelines; Health; Histologic; Histology; Image; Immunohistochemistry; Inbreeding; Inflammation; Inflammatory; Instruction; interest; joint function; joint injury; Joints; Knowledge; Locomotion; Measures; Mechanics; Medicine; Modeling; Molecular; mouse model; Mouse Strains; Mus; Musculoskeletal; next generation; novel therapeutic intervention; Pain; pain relief; pain sensitivity; Pathology; Process; programs; Protocols documentation; Quality Control; Reagent; repository; Reproducibility; Research; Research Personnel; Resources; Rest; Rheumatoid Arthritis; Rodent Model; Running; Sampling; Sensorimotor functions; Serum; Source; Standardization; Supervision; Swelling; Symptoms; Testing; Therapeutic Intervention; Time; Tissues; Training; treadmill; Universities; Washington; ","Animal Models of Joint Injury and Disease","074992","ZAR1","Special Emphasis Panel ","5349","","01","100000","56625","","156625"
"9755740","F31","HL","1","N","04/06/2019","04/11/2019","04/10/2020","837","F31HL147399","","PA-18-671","1F31HL147399-01","NHLBI:40182\","TRAINING, INDIVIDUAL","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CINCINNATI","UNITED STATES","","01","071284913","US","615001","CINCINNATI CHILDRENS HOSP MED CTR","OH","452293039","Project Narrative The spectrum of congenital heart defects (CHDs) that affect atria are the third most common heart malformation and constitute approximately 40% of all heart defects diagnosed in adults. However, the molecular etiology underlying most CHDs is not understood. Knowledge gleaned from this proposal will contribute to ongoing efforts to characterize the development of adult CHDs as well as aid in generating effective preventative and treatment strategies.","14627512; ","GAFRANEK, JACOB ;","SCOTT, JANE","04/11/2019","04/10/2022","Adolescent; Adult; Affect; Alleles; apoAI regulatory protein-1; Atrial Heart Septal Defects; atrioventricular septal defect; Birth; Cardiac; Cardiac Myocytes; cardiogenesis; Cardiomyopathies; Cells; Cellular Morphology; Characteristics; Child; Congenital Abnormality; Congenital Heart Defects; Connective Tissue; Data; Defect; Development; Diagnosis; Dirofilaria immitis; Embryo; Engineering; Ethylnitrosourea; Etiology; Exhibits; experience; falls; Fertilization; Frequencies; Gene Expression; Generations; Genes; Genetic; Glean; Heart; Heart Abnormalities; Heart Atrium; Histologic; Human; Immunohistochemistry; In Situ Hybridization; in utero diagnosis; in vivo; Infant; insight; Knowledge; Label; Lead; Life; Maintenance; Mediating; Methods; Modeling; Molecular; Mus; Mutagenesis; mutant; Mutation; Names; Newborn Infant; novel; Nuclear Hormone Receptors; Orphan; Pharmacology; preservation; Prevalence; prevent; Prevention strategy; Proteins; Repression; Role; Signal Transduction; Source; Stains; Structure; System; Testing; Tissues; tool; transcriptome; transcriptome sequencing; Transgenic Organisms; treatment strategy; Tretinoin; Venous; Ventricular; Vertebrates; Work; Zebrafish; ","Nr2f1a suppresses bulbous arteriosus identity in the zebrafish atrium","147399","ZRG1","Special Emphasis Panel ","","","01","40182","","40182",""
"9759639","F31","HL","1","N","03/21/2019","04/01/2019","03/31/2020","837","F31HL147404","","PA-18-671","1F31HL147404-01","NHLBI:45016\","TRAINING, INDIVIDUAL","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LOS ANGELES","UNITED STATES","","28","075307785","US","1225501","CEDARS-SINAI MEDICAL CENTER","CA","900481804","PROJECT NARRATIVE Our group has shown the vital role that GJA1-20k plays in delivery of Cx43 to the cell membrane to maintain healthy heart contractions. A recent publication (Basheer et al, 2017) and preliminary data indicates that GJA1- 20k may also be directly interacting with actin, and that GJA1-20k overexpression can stabilize actin in the cell. We hope to further understand the role of GJA1-20k as an actin interactor and to discover how this process can be used to protect Cx43 delivery, thereby protecting heart contraction and function, during cardiac stress.","15453454; ","BAUM, RACHEL ;","HUANG, LI-SHIN","04/01/2019","03/31/2022","Actin-Binding Protein; Actins; Adult; Affect; Arrhythmia; base; Binding; Binding Sites; Cardiac; Cardiac Myocytes; Cause of Death; Cell membrane; Cell Nucleus; Cells; cellular imaging; Cessation of life; Code; Connexin 43; Connexins; Coupling; Cytoskeleton; Data; domain mapping; Exons; Fiber; G Actin; Gap Junctions; Generations; Genes; Goals; Heart; Heart Contractilities; Heart Diseases; heart function; Hela Cells; Image; improved; Incubated; Ions; Ischemia; Laboratories; latrunculin A; Mediating; Messenger RNA; Methionine; Methods; Microfilaments; Microtubules; Molecular; Muscle Contraction; Mutagenesis; Myocardial; Myocardial Contraction; Myocardial Ischemia; Myocardium; novel; overexpression; Play; polymerization; Polymers; pre-doctoral; prevent; Process; Protein Isoforms; Proteins; Publications; Rest; Role; Site; Stress; Tail; Testing; Thick; trafficking; Translating; United States; Work; ","GJA1-20K is a new regulator of actin dynamics and myocardial cell-cell coupling","147404","ZRG1","Special Emphasis Panel ","","","01","45016","","45016",""
"9771163","I01","VA","1","N","04/26/2019","04/01/2019","03/31/2020","999","I01CX001864","","RFA-CX-18-001","1I01CX001864-01A1","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","CHICAGO","UNITED STATES","","07","010299204","US","481026","JESSE BROWN VA MEDICAL CENTER","IL","606123728","Chronic myeloid leukemia (CML) is a malignant bone marrow disorder of middle aged and elderly adults. Use of tyrosine kinase inhibitors (TKIs) directed to the Bcr-abl oncogene has prolonged survival in CML. Recent clinical trials determined that a subset of CML patients are able to discontinue TKI treatment and sustain a prolonged remission. However, ~50% of patients relapse after discontinuing treatment and molecular markers associated with relapse vs sustained remission are unknown. The goal of our studies is to identify molecular markers of relapse in human CML subjects undergoing a therapy discontinuation attempt according to standard of care, clinical practice guidelines.","1898025; ","EKLUND, ELIZABETH ANN;","","04/01/2019","03/31/2023","abl Oncogene; Adult; Adverse effects; Aftercare; Apoptosis; Blast Phase; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Bone Marrow Transplantation; Calpain; calpain inhibitor; Cells; cellular transduction; Characteristics; Chronic; Chronic Myeloid Leukemia; Chronic Phase; Clinical; Clinical Practice Guideline; Clinical Trials; cost; cytokine; Development; discontinuation study; Disease remission; Elderly; follow-up; fusion gene; Future; Generations; Genes; glycogen synthase kinase 3 beta inhibitor; Goals; Guidelines; Healthcare Systems; Human; Imatinib; In complete remission; Incidence; Individual; inhibitor/antagonist; Innate Immune Response; interest; leukemia stem cell; Malignant - descriptor; middle age; Modeling; Molecular; molecular marker; mouse model; Mus; Mutation; Myeloid Leukemia; National Comprehensive Cancer Network; Newly Diagnosed; Ontology; Outcome; Pathway interactions; Patients; Population; pre-clinical; preclinical study; prevent; Production; Prognostic Marker; Regulation; Relapse; relapse patients; relapse prediction; relapse risk; Research Personnel; Resistance; response; Ribonucleases; Sampling; Secondary to; Signal Transduction; single-cell RNA sequencing; standard of care; Stem Cell Leukemia; survivin; therapeutic target; tool; Transcript; transcriptome; transcriptome sequencing; Translating; Transplantation; Tyrosine Kinase Inhibitor; Xenograft procedure; ","Identifying molecular markers that predict relapse after therapy discontinuation inchronic myeloid leukemia.","001864","ZRD1","Special Emphasis Panel ","","A1","01","","","",""
"9777154","R44","HL","2","N","04/23/2019","04/24/2019","03/31/2020","839","R44HL131338","","PA-18-574","2R44HL131338-02","NHLBI:1261442\","SBIR-STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BUTLER","UNITED STATES","","03","100758015","US","3733201","ENSION, INC.","PA","16002","Project Narrative: Current in vitro systems and methods to assess blood compatibility of biomaterials and medical products have been unable to achieve a comprehensive understanding of the blood-biomaterial interaction to predict in vivo performance. This Phase II proposes the main research and development effort of a standardized, cost effective, bench top blood circulation loop and accompanying testing protocols that can comprehensively address all five categories of blood compatibility and account for each Virchow variable in a single, highly controlled test.","8300257; ","CAHALAN, PATRICK THOMAS;","OCHOCINSKA, MARGARET J","08/15/2016","03/31/2020","Address; Analysis of Variance; Area; base; Biocompatible Materials; biomaterial compatibility; biomaterial development; Blood; Blood Circulation; Blood Coagulation Disorders; Blood flow; Blood Platelets; Categories; Catheters; Clinical; Coagulation Process; Communities; Complement; Confidence Intervals; Consensus; cost; cost effective; Data; design; Development; Diagnostic; Documentation; Evaluation; experimental study; Freezing; Goals; Human; In Vitro; in vivo; Inflammation; Injections; leukocyte activation; manufacturability; Measures; Mediator of activation protein; Medical; Medical Device; Methodology; Methods; Molds; Notification; Performance; Phase; Physiological; Process; Production; programs; Protocols documentation; prototype; Recording of previous events; Reproducibility; Research; research and development; response; Standardization; Surface; surface coating; System; Techniques; Testing; Thrombosis; tool; tool development; Triad Acrylic Resin; Uncertainty; Work; ","System and comprehensive approach for blood compatibility of medical devices and biomaterial","131338","ZRG1","Special Emphasis Panel ","","","02","","","1261442",""
"9782137","I01","VA","2","N","04/22/2019","04/01/2019","03/31/2020","999","I01BX002327","","RFA-BX-18-001","2I01BX002327-05A1","","Non-SBIR/STTR RPGs","2019","Veterans Affairs","","CHARLESTON","UNITED STATES","","01","039807318","US","481111","RALPH H JOHNSON VA MEDICAL CENTER","SC","294015703","Congestive heart failure is the leading cause of death of Veterans in the United States. The healing response within the myocardium after a heart attack is complex and involves both temporal and regional changes including inflammation, cardiac scar formation, and tissue remodeling. We have discovered that inhibition of an enzyme called histone deacetylase after a heart attack results in the earlier resolution of inflammation and contributes to better healing of the heart. Our work identifies a very promising therapeutic opportunity to improve treatment of our VA patients who have suffered a heart attack.","2452632; ","MENICK, DONALD R.;","","10/01/2014","03/31/2023","Acetylation; Affect; African American; Alcohol consumption; Anti-inflammatory; Appearance; Area; Back; Cardiac; Cause of Death; CD86 gene; Cells; Cessation of life; Chromatin Structure; Cicatrix; Clinical Treatment; Complex; Congestive Heart Failure; Coronary heart disease; cytokine; Data; Death Rate; Diabetes Mellitus; EFRAC; Endothelial Cells; Environment; Enzyme Inhibition; Enzymes; epigenetic regulation; Equilibrium; Excision; Extracellular Matrix; Fibroblasts; Fibrosis; Fostering; Gene Expression; Gene Expression Profiling; Genetic Transcription; Glycopeptides; healing; Heart; heart damage; heart disease risk; Heart Diseases; Heart failure; Heterogeneity; Histone Deacetylase; Histone Deacetylase Inhibitor; Histones; Hour; Hypertension; Image; improved; Infarction; Inflammation; Inflammatory; injured; Injury; insight; Interleukin-10; Interleukin-4; Kinetics; Lead; Lipids; macrophage; Maps; Mass Spectrum Analysis; Matrix Metalloproteinases; Mediating; Mediator of activation protein; men; Modeling; Molecular; monocyte; mortality; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myofibroblast; nanoparticle; Necrosis; neovascularization; neutrophil; Obesity; Overweight; patient population; Patients; Peptide Hydrolases; Peptides; Phagocytes; Phagocytosis; Phase; Phenotype; Play; Polysaccharides; Population; Population Heterogeneity; Pre-Clinical Model; preservation; Process; Proteolysis; recruit; Regulation; repaired; Resolution; response; Reverse Transcriptase Polymerase Chain Reaction; Role; Smoking; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stem cells; targeted delivery; Testing; Therapeutic; tissue regeneration; Tissues; transcription factor; transcriptome; Transferase; Translating; translational approach; treatment strategy; United States; Ventricular Function; Ventricular Remodeling; Veterans; Woman; Work; ","Regulatory Role of HDAC in Post-MI Ventricular Remodeling","002327","ZRD1","Special Emphasis Panel ","","A1","05","","","",""
"9838625","R21","DE","3","N","04/18/2019","04/22/2019","09/30/2020","663","R21DE027235","","PA-18-936","3R21DE027235-02S2","OD:202995\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH","","SAN JUAN","UNITED STATES","","98","948108063","US","578705","UNIVERSITY OF PUERTO RICO MED SCIENCES","PR","009365067","Project Narrative: In many regions, such as Puerto Rico and some states in the mainland with tropical climates (e.g., South Florida), the Zika virus is projected to become endemic. The greatest burden of intrauterine Zika infection is to the fetus, through increased risks of craniofacial and dental development abnormalities. This interdisciplinary study will define the craniofacial and dental phenotypes of children exposed to the Zika virus during gestation, with biological samples collected for future studies related to the impact of the virus.","8952507; ","CAMPOS, MARIBEL ;","SHUM, LILLIAN","04/22/2019","09/30/2020","Adverse effects; adverse pregnancy outcome; Affect; Biological; Birth; Blinded; Brain; Child; Clinical; Congenital Abnormality; craniofacial; craniofacial development; Data; Dental; Development; Diagnostic radiologic examination; Exposure to; Face; fetal; Fetal Development; Fetus; Florida; Future; Health; Health Status; Imaging Techniques; Infant; Interdisciplinary Study; International; Knowledge; member; Microcephaly; Mothers; Odontogenesis; Oral health; Outcome; Periodontal Diseases; Phenotype; Postpartum Period; Pregnancy; Pregnant Women; public health emergency; Puerto Rico; Risk; Role; Sampling; skeletal; Surface; Tropical Climate; vector transmission; viral transmission; Virulence; Virus; Woman; Zika Virus; ZIKV infection; ","Dental and Craniofacial Effects of Intrauterine Zika Virus Infection","027235","","","","S2","02","135330","67665","202995",""
"9841850","Y01","AI","","N","","","","","Y01AI130030","","","AAI13003001-1-0-1","NIAID:63158\","INTERAGENCY AGREEMENTS","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","","","","","","","","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","","","; ",",  ;","","","","Basic Science; Leishmania; Leishmaniasis; Lutzomyia genus; Maintenance; National Institute of Allergy and Infectious Disease; Phlebotomus; repository; Research Personnel; Resources; Sand Flies; web site; ","Provision of Phlebotomine Sand Flies for Leishmania","","","","","","","","","63158",""
"9850417","R01","MH","3","N","04/26/2019","04/16/2019","11/30/2019","242","R01MH109525","SCHOOLS OF PHARMACY","PA-18-591","3R01MH109525-03S1","NIMH:119999\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","RICHMOND","UNITED STATES","PHARMACOLOGY","04","105300446","US","353201","VIRGINIA COMMONWEALTH UNIVERSITY","VA","232980568","NARRATIVE DNA methylation studies offer great potential to improve the understanding of schizophrenia but the critical questions of whether associated methylation marks truly indicate disease risk, or if they reflect changes caused by the disease, or disease related confounders, remain to be investigated. Our goal is to disentangle these questions by studying the methylome in human samples collected pre- and post schizophrenia onset. The successful completion of the proposed work may identify biomarkers and functional methylation marks for SZ in general and may specifically identify markers with potential to predict SZ risk, which would be of tremendous value for improved SZ treatment and care.","10240813; ","ABERG, KAROLINA ANNA;","KOESTER, SUSAN E","04/16/2019","11/30/2019","Address; Affect; Affinity; Algorithms; Antipsychotic Agents; Autopsy; base; Binding; Bioinformatics; Biological; Biological Assay; Biological Markers; Birth; bisulfite sequencing; Blood; Blood specimen; Brain; brain tissue; Caring; case control; Case-Control Studies; Cell division; cell type; Clinic; Clinical; clinical application; Collection; Complex; Computer software; cost; Cost Measures; Data; design; Development; Diagnosis; Diagnostic; Diet; Disease; Disease remission; disorder risk; DNA; DNA Methylation; early detection biomarkers; Early Diagnosis; Ethics; Etiology; Event; experimental study; follow-up; Gene Expression; Genetic; Genetic Transcription; Genomic DNA; Genomics; Goals; Gold; Hematological Disease; Histones; Human; Human Genome; improved; Individual Differences; innovation; insight; Investigation; Knowledge; Life; Life Style; Light; Measures; Mental disorders; Methods; Methylation; methylation biomarker; methylation pattern; methylome; methylomics; Neonatal; novel; outcome forecast; Pathogenicity; Pathway Analysis; Pathway interactions; Patients; Pattern; Performance; Phenylketonurias; Predisposition; Process; Protein Binding Domain; Psychological Stress; Relapse; Risk; risk variant; Sampling; Schizophrenia; screening; Site; Smoking; Spottings; Symptoms; Testing; theories; Tissues; Transcript; transcriptome; transcriptome sequencing; transcriptomics; Validation; Variant; whole genome; Work; ","Schizophrenia case-control study of neonatal and post onset methylomes","109525","","","","S1","03","77325","42674","119999",""
"9854426","R01","DA","3","N","04/23/2019","03/01/2019","02/29/2020","279","R01DA041356","SCHOOLS OF MEDICINE","PA-18-906","3R01DA041356-03S1","NIDA:57928\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","SEATTLE","UNITED STATES","PSYCHIATRY","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","Project Narrative Cocaine addiction is a devastating, progressive brain disorder that involves adaptations in the cellular structure and molecular signaling in neurons after repeated exposure to cocaine. This project intends to reveal a new level of detailed information about the molecular and cellular adaptations affecting neuronal signaling involved in drug seeking with the purpose of identifying novel strategies to reduce compulsive cocaine use and seeking.","1929020; ","NEUMAIER, JOHN F;","SORENSEN, ROGER","05/01/2017","02/28/2022","Abstinence; addiction; adeno-associated viral vector; Affect; Animal Model; Automobile Driving; base; Behavior; Behavioral; Brain; Brain Diseases; Brain region; CAV2 gene; Cells; Cellular Structures; Cocaine; Cocaine Dependence; cocaine exposure; cocaine use; combinatorial; Complex; compulsion; Corpus striatum structure; craving; Data; Decision Making; Dendrites; designer receptors exclusively activated by designer drugs; drug relapse; Drug usage; Engineering; Event; experience; experimental study; Exposure to; Extinction (Psychology); Gases; Genetic Transcription; Globus Pallidus; Glutamates; Goals; Individual; innovation; intersectionality; Knowledge; Laboratories; LoxP-flanked allele; Measures; Mediating; Messenger RNA; Methods; MicroRNAs; Modeling; Molecular; Monitor; Neurons; neurotransmission; new therapeutic target; novel; novel strategies; Nucleus Accumbens; Output; Pathway Analysis; Pathway interactions; Pattern; Pharmaceutical Preparations; Play; Polyribosomes; Process; Protein Biosynthesis; Proteins; Rattus; receptor; receptor expression; Relapse; response; retrograde transport; Ribosomes; RiboTag; RNA; Role; Second Messenger Systems; selective expression; Self Administration; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Specific qualifier value; Synapses; Synaptic plasticity; Synaptosomes; Technology; Testing; Time; tool; Training; transcriptome sequencing; transgene expression; Transgenes; Transgenic Organisms; Translating; Translations; treatment strategy; Ventral Striatum; Ventral Tegmental Area; Viral Vector; ","Mechanisms of pathway-specific plasticity in the incubation of craving","041356","MNPS","Molecular Neuropharmacology and Signaling Study Section ","","S1","03","37253","20675","57928",""
"9869307","T32","NS","3","N","04/23/2019","04/01/2019","06/30/2019","853","T32NS007491","","PA-18-591","3T32NS007491-18S2","NINDS:756\","TRAINING, INSTITUTIONAL","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","2084812; ","KNOLLMAN, BJORN C;","WEIGAND, LETITIA ALEXIS","04/01/2019","06/30/2019","Biology; Ion Channel; Training Programs; ","Training Program in Ion Channel and Transporter Biology","007491","","","","S2","18","700","56","756",""
"9901995","U01","HG","3","N","04/25/2019","04/25/2019","03/31/2020","172","U01HG008666","","RFA-HG-14-025","3U01HG008666-04S1","NHGRI:742762\","Non-SBIR/STTR RPGs","2019","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","CINCINNATI","UNITED STATES","","01","071284913","US","615001","CINCINNATI CHILDRENS HOSP MED CTR","OH","452293039","PUBLIC HEALTH RELEVANCE: The Cincinnati Children's Hospital Medical Center (CCHMC) proposes to contribute as a funded site in the eMERGE III Network by pursuing a series of initiatives designed to advance genomics and the electronic health record (EHR). We propose 100 genes to evaluate by sequencing in 2,000 patients consented for return of results, to advance genomics by evaluating fee for service for DNA sequence-based genetic testing at CCHMC, to develop the reliable identification many diseases in the EHR and along with genome wide genetic testing, to explore genetic variants for alleged and unknown clinical manifestations, to extend the work of eMERGE to other large collections of EHR and genetic data, to evaluate cost benefits of genetic testing, to characterize the genetics of pain, to explor the preferences of adolescents concerning the genetic results they prefer to learn, and to explore the legal, ethical, and social issues that surround the re-interpretation of genetic variants. All of this work will be pursued with our eMERGE III Network colleagues the goal of improving the quality of the health care we deliver.","8496203; ","HARLEY, JOHN BARKER;","ROWLEY, ROBB KENNETH","09/01/2015","03/31/2020","Abdominal Aortic Aneurysm; Address; Administrator; Adolescent; Algorithms; Appendicitis; Archives; Attention deficit hyperactivity disorder; Autistic Disorder; base; Base Sequence; biobank; Boston; Budgets; Caregivers; Caring; Child; Childhood; Chronic Obstructive Airway Disease; Clinical; clinical care; clinical decision support; clinically actionable; Code; cohort; Collaborations; Collection; Computer software; Computerized Medical Record; Computers; Consent; cost; Costs and Benefits; CYP3A5 gene; Data; data modeling; data warehouse; database of Genotypes and Phenotypes; Decision Making; design; Disease; DNA; DNA Sequence; DNA Sequence Analysis; DNA sequencing; Dose; economic impact; Effectiveness; Ehlers-Danlos Syndrome; electronic data; Electronic Health Record; Electronic Medical Records and Genomics Network; Elements; ethical legal social implication; Ethics; Evaluation; Faculty; Familial Hypercholesterolemia; Fee-for-Service Plans; Fibromyalgia; follow-up; Foundations; Funding; gene panel; Gene Targeting; Genes; Genetic; genetic information; Genetic screening method; genetic variant; genome-wide; Genomic medicine; genomic variation; Genomics; Genotype; Goals; health care delivery; health care quality; Healthcare; Healthcare Systems; heuristics; Human Resources; improved; Individual; Informatics; Infrastructure; Institution; interest; Investments; Kidney Transplantation; Learning; learning strategy; Legal; Legal Obligations; Letters; Machine Learning; Malignant hyperpyrexia due to anesthesia; Medical center; Medical Records; member; Migraine; Modification; Mosaicism; Narcotic Addiction; Natural Language Processing; Neonatal Abstinence Syndrome; next generation sequencing; Outcome; Outcomes Research; Outpatients; Pain; Parents; Patient Care; patient oriented; Patients; Pediatric Hospitals; Pharmacogenomics; Phenotype; Physicians; pleiotropism; Policies; Positioning Attribute; preference; Primary Ciliary Dyskinesias; primary pulmonary hypertension; Process; Productivity; programs; PTEN gene; public health relevance; Pyloric Stenosis; Recommendation; Records; Research; Research Institute; Research Personnel; response; Ritalin; Running; Sampling; Scientist; Sequence Analysis; Series; Site; skills; social; success; support tools; Tacrolimus; Testing; Textiles; Time; Tonsillectomy; tool; tool development; Translating; Variant; Veterans; Work; ","Better Outcomes for Children: Promoting Excellence in Healthcare Genomics to Inform Policy","008666","ZHG1","Special Emphasis Panel ","","S1","04","467146","275616","742762",""
"9902641","R43","AI","3","N","04/01/2019","04/22/2019","07/31/2019","855","R43AI136134","","PA-17-302","3R43AI136134-01A1S1","NIAID:55000\","SBIR-STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","VESTAL","UNITED STATES","","22","080438429","US","10045990","EXCELSIOR BIOFILMS, LLC","NY","13850","Project Narrative The current proposal is a request for funding to begin the early-stage development of a novel adjunctive to antimicrobial treatment of biofilm infections caused by Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus; pathogens for which new, alternative antibiotic development has been identified as a critical or high priority. By stimulating the innate biofilm dispersion response, this adjunctive offers a unique and innovative antimicrobial strategy for enhancing the treatment of recalcitrant infections while generating minimal selective pressure for drug-resistance.","15627492; ","WOODS, PAUL ;","XU, ZUOYU","08/20/2018","07/31/2019","Acinetobacter baumannii; Adhesions; Animal Model; Antibiotics; antimicrobial; antimicrobial drug; Bacitracin; Bacteria; Bacteriophages; base; Candida albicans; Caring; Cell Communication; cell motility; Cells; Chronic Disease; Combined Modality Therapy; Communication; Computer software; cytotoxicity; Decenoic Acid; Development; Drug resistance; Enzymes; expectation; experimental study; Exposure to; Formulation; Funding; fungus; Goals; Gram-Negative Bacteria; Gram-Positive Bacteria; Growth; Histologic; Human; Image; improved; in vitro Model; Infection; inhibitor/antagonist; innovation; Investigation; keratinocyte; Laboratories; Lasers; Measures; Metabolic; Methods; microbial; Microbial Biofilms; Modeling; Monitor; monolayer; Mus; nanomolar; National Institute of Allergy and Infectious Disease; Neomycin; novel; Nutrient; Ointments; pathogen; Petrolatum; Phase; Physiological; Physiology; Polymyxin B; Population; Preparation; pressure; prevent; Prevention; Prevention strategy; priority pathogen; Pseudomonas aeruginosa; quorum sensing; Research; response; Safety; Scanning; Signal Transduction; Signaling Molecule; Skin; Slide; Staphylococcus aureus; Sterile coverings; Structure; System; Testing; Therapeutic; Topical Antibiotic; Topical application; Translational Research; treatment effect; treatment strategy; United States National Institutes of Health; uptake; Work; wound; wound closure; Wound Healing; ","Incorporation of a biofilm dispersion autoinducer into an antimicrobial ointment for the treatment of topical wounds","136134","ZRG1","Special Emphasis Panel ","","A1S1","01","","","55000",""
"9916032","UG1","DA","3","N","04/25/2019","03/29/2019","05/31/2019","279","UG1DA013035","SCHOOLS OF MEDICINE","RFA-DA-15-008","3UG1DA013035-17SB","NIDA:973826\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","NEW YORK","UNITED STATES","PSYCHIATRY","12","121911077","US","5998304","NEW YORK UNIVERSITY SCHOOL OF MEDICINE","NY","10016","PUBLIC HEALTH RELEVANCE:  Addictions, including nicotine, drugs and alcohol, represent a major public health problem. Research is needed to translate new basic and therapeutic advances into effective and accessible treatment in our communities. The NIDA Clinical Trials Network and the Greater New York Node seek to fill this gap by engaging researchers, healthcare providers from primary care to specialty care, and policy-makers in research to improve addictions treatment nationally using science as the vehicle.","8192463; 2414926 (contact); ","NUNES, EDWARD V.; ROTROSEN, JOHN P (contact);","DOBBINS, RONALD","01/10/2001","05/31/2020","Academia; addiction; Address; Adolescent; Adopted; Adoption; Alcoholism; Alcohols; Area; base; Behavior Therapy; behavioral health; Budgets; care coordination; care outcomes; care providers; Caribbean region; Caring; Charge; Cities; Clinical; Clinical Management; Clinical Trials; Clinical Trials Network; Collaborations; college; Communities; comparative effectiveness; cost; Criminal Justice; Data; Development; Disease; disorder prevention; Early Intervention; eHealth; Electronic Health Record; epidemiology study; experience; Fostering; Freedom; Funding; Future; Gender Issues; Genetic; Genetic Research; Goals; Health; health care service organization; health care settings; health information technology; health management; Health Personnel; Health Services; Health Services Research; Health system; Healthcare Systems; Hepatitis C virus; HIV; HIV/HCV; Hospitals; improved; improved outcome; Individual; Infection; Infrastructure; innovation; Institution; Leadership; Learning; Long Island; Mainstreaming; Medical; Medical Informatics; medical schools; medical specialties; Medical Technology; Medicine; Mental disorders; Mental Health; Mentorship; Methodology; Methods; metropolitan; mHealth; National Institute of Drug Abuse; neuroimaging; Neurosciences; Neurosciences Research; New York; next generation; Nicotine; Patients; Pediatrics; performance site; Pharmaceutical Preparations; Pharmacotherapy; Phase; Policy Maker; Population; pragmatic trial; Prevention; Primary Health Care; Private Hospitals; programs; Provider; Public Health; public health relevance; Public Hospitals; Registries; Research; Research Personnel; Research Training; Resources; Risk Reduction; Science; screening; Services; Smoking; Substance abuse problem; Substance Use Disorder; System; Technology Transfer; Testing; Therapeutic; Training; Translating; treatment program; treatment services; treatment strategy; Universities; vaccine development; Vision; ","NIDA Clinical Trials Network: Greater New York Node","013035","ZDA1","Special Emphasis Panel ","","SB","17","922475","51351","973826",""