"APPLICATION_ID","ACTIVITY","ADMINISTERING_IC","APPLICATION_TYPE","ARRA_FUNDED","AWARD_NOTICE_DATE","BUDGET_START","BUDGET_END","CFDA_CODE","CORE_PROJECT_NUM","ED_INST_TYPE","FOA_NUMBER","FULL_PROJECT_NUM","FUNDING_ICs","FUNDING_MECHANISM","FY","IC_NAME","NIH_SPENDING_CATS","ORG_CITY","ORG_COUNTRY","ORG_DEPT","ORG_DISTRICT","ORG_DUNS","ORG_FIPS","ORG_IPF_CODE","ORG_NAME","ORG_STATE","ORG_ZIPCODE","PHR","PI_IDS","PI_NAMEs","PROGRAM_OFFICER_NAME","PROJECT_START","PROJECT_END","PROJECT_TERMS","PROJECT_TITLE","SERIAL_NUMBER","STUDY_SECTION","STUDY_SECTION_NAME","SUBPROJECT_ID","SUFFIX","SUPPORT_YEAR","DIRECT_COST_AMT","INDIRECT_COST_AMT","TOTAL_COST","TOTAL_COST_SUB_PROJECT"
"9908473","F32","AI","1","N","02/03/2020","02/03/2020","11/02/2020","855","F32AI145283","SCHOOLS OF MEDICINE","PA-19-188","1F32AI145283-01A1","NIAID:53573\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","Project Narrative This proposal has the potential to yield a new paradigm for the function of regulatory T cells (Tregs), an indispensable immune subset that plays a critical role in maintaining immune homeostasis and therefore has implications in autoimmune diseases as well as cancer.","11933194; ","SO, LOMON ;","GONDRE-LEWIS, TIMOTHY A","02/03/2020","11/02/2021","Affinity Chromatography; Antigen-Presenting Cells; Autoantigens; Autoimmune Diseases; base; Bioinformatics; Biological; Biological Assay; Biological Process; biological systems; Biology; CD4 Positive T Lymphocytes; Cells; Cellular Structures; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Critical Pathways; Data; Development; DNA; DNA Sequence Alteration; effector T cell; Epitopes; Eragrostis; Event; experimental study; follow-up; FOXP3 gene; Gene Expression; Gene Expression Regulation; Genetic; genetic information; genome-wide; Homeostasis; Human; Immune; Immune response; Immune Tolerance; Immunity; Immunoprecipitation; In Vitro; in vivo; Link; Logic; Luciferases; Malignant Neoplasms; Mass Spectrum Analysis; Mature T-Lymphocyte; Mediating; Messenger RNA; Modeling; Molecular; Molecular Biology Techniques; mouse model; Mus; Mutagenesis; novel; Output; Play; programs; Proteins; Proteome; recruit; Regulation; Regulatory Element; Regulatory T-Lymphocyte; Reporter; Research; Ribosomal Proteins; Ribosomes; RiboTag; RNA; Role; Signal Pathway; Specificity; stem; Syndrome; Time; tool; Transcript; transcriptome; transcriptomics; Transgenic Mice; Translating; translation factor; Translation Process Protein; Translations; translatome; Untranslated Regions; ","Regulatory T cells impose specific translatome changes in effector CD4 T cells","145283","ZRG1","Special Emphasis Panel ","","A1","01","53573","","53573",""
"9910740","F31","GM","1","N","01/14/2020","03/26/2020","03/25/2021","859","F31GM136143","SCHOOLS OF ARTS AND SCIENCES","PA-19-196","1F31GM136143-01","NIGMS:37906\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","DAVIS","UNITED STATES","ANATOMY/CELL BIOLOGY","03","047120084","US","577503","UNIVERSITY OF CALIFORNIA AT DAVIS","CA","956186153","Project Narrative Transcription is essential for gene expression, producing an RNA copy of the DNA template. Sometimes the RNA can become entangled with the DNA, creating so called R-loop structures. This project will investigate whether splicing factors that control gene expression can also regulate the formation of R-loops.","14638838; ","CASTILLO GUZMAN, DAISY ;","BROWN, PATRICK","03/26/2020","03/25/2022","actionable mutation; Acute; Acute Erythroblastic Leukemia; Acute Myelocytic Leukemia; Affect; Architecture; ATAC-seq; base; Binding; Cell Line; Cells; Cellular Stress; Chromatin; Chromatin Structure; Complex; Data; Defect; Deposition; Disease; DNA; DNA biosynthesis; DNA Structure; DNA-Directed RNA Polymerase; Dysmyelopoietic Syndromes; Elderly; ENG gene; Enzymes; Essential Genes; Event; Gene Expression; Genes; Genetic Transcription; genome-wide; Genomic Instability; Genomics; Goals; Hematological Disease; Hour; Human; Human Genome; Hybrids; insight; Invaded; K-562; K562 Cells; Lead; Link; Literature; Measures; Mediating; Medical; Metabolism; Molecular; Mutagenesis; Mutation; Natural Products; novel; Nucleosomes; Oxidative Stress; Pathologic; Pattern; Physiological; Play; prevent; Process; Regulation; replication stress; Resolution; response; ribonuclease H1; RNA; RNA Splicing; Role; Spliced Genes; Spliceosome Assembly Pathway; Spliceosomes; Stress; Structure; Testing; Time; tool; Transcript; Transcription Elongation; transcriptome sequencing; U2 Small Nuclear Ribonucleoprotein; Virus Diseases; ","Uncovering novel roles for splicing factor SF3B1 in transcription dynamics, R-loop metabolism, and chromatin structure","136143","ZRG1","Special Emphasis Panel ","","","01","37906","","37906",""
"9930371","R01","ES","3","N","03/20/2020","03/23/2020","01/31/2021","113","R01ES030101","","PA-18-592","3R01ES030101-02S1","NIEHS:200657\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","PORTLAND","UNITED STATES","","01","071732663","US","4757601","MAINEHEALTH","ME","041023175","PROJECT NARRATIVE Obesity and osteoporosis are global epidemics marked by costly associated health problems, and identifying preventable childhood determinants and intervening in early life is a public health imperative. This study will investigate the role of childhood exposures to the environmental chemicals per- and polyfluoroalkyl substances and phthalates on adolescent markers of obesity and osteoporosis risk. Our findings will influence policies to limit chemical production and individual behaviors to minimize exposures.","11008907; ","FLEISCH, ABBY ;","JOUBERT, BONNIE","03/23/2019","01/31/2022","12 year old; 17 year old; 8 year old; Accounting; Address; Adolescence; Adolescent; Adult; adult obesity; Alcohol or Other Drugs use; animal data; Animal Model; Archives; Area; base; Behavior; Biological Assay; Biological Markers; Body Composition; bone; Bone Density; bone mass; Boston; career; chemical association; Chemical Exposure; Chemicals; Child; Childhood; cohort; Comorbidity; consumer product; Consumption; cost; critical developmental period; Data; Development; Diet; Dietary Factors; Dietary History; Disease; disorder risk; Dual-Energy X-Ray Absorptiometry; early adolescence; Endocrine; Endocrinology; Environment; environmental chemical; Environmental Exposure; Environmental Impact; Epidemic; epidemiology study; Evaluation; exposed human population; Exposure to; Family; fast food; follow-up; Food; food consumption; Funding; Genetic; Health; Individual; insight; Investigation; Lead; Life; Link; Measurement; Meat; Mediating; Mediator of activation protein; novel; Obesity; obesity in children; obesity risk; Osteoporosis; Pathway interactions; Peroxisome Proliferator-Activated Receptors; phthalates; Physical activity; Plasma; Plasticizers; Policies; Population Study; Positioning Attribute; Predictive Factor; prevent; Prevention strategy; Preventive Intervention; Preventive measure; Process; Production; prospective; Puberty; Public Health; public health priorities; Research Personnel; Risk; Risk Factors; Role; Scientist; sociodemographics; Source; Stains; Suggestion; Testing; Toxic Environmental Substances; transcription factor; United States National Institutes of Health; Urine; western diet; Work; ","Environmental Chemicals, Adiposity, and Bone Accrual Across Adolescence","030101","ZES1","Special Emphasis Panel ","","S1","02","116661","83996","200657",""
"9933394","P40","OD","2","N","03/23/2020","02/10/2020","01/31/2021","","P40OD010938","","PAR-17-006","2P40OD010938-40","OD:35772\","RESEARCH CENTERS","2020","OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH","","HOUSTON","UNITED STATES","","09","800772139","US","578407","UNIVERSITY OF TX MD ANDERSON CAN CTR","TX","770304009","","2079066; ","WILLIAMS, LAWRENCE E;","","","","Adjuvant; Affect; Age; Applied Research; Area; Behavior; Behavioral; behavioral study; Biological Assay; Biology; Breeding; Cell Culture Techniques; Cells; Cerebral Amyloid Angiopathy; Characteristics; Communities; Complement; computerized; Doctor of Medicine; Doctor of Philosophy; Emotional; Funding; Grant; gut microbiome; gut microbiota; Health; Human; Immune; immune function; Immune system; Immunology; insight; Knowledge; Language; Lead; Lymphocyte Subset; Maps; microbiome; microbiome research; monocyte; Phagocytosis; Phenotype; Population; programs; Reagent; Research; Research Personnel; Research Project Grants; Resources; Saimiri; sex; System; Taxonomy; Testing; Training; trait; United States National Institutes of Health; Vaccines; Work; ","Squirrel Monkey Breeding and Research Resource: Applied Research","010938","ZRG1","Special Emphasis Panel ","5281","","40","22357","13415","","35772"
"9937893","R01","AI","1","N","03/24/2020","03/24/2020","02/28/2021","855","R01AI150897","SCHOOLS OF MEDICINE","PA-19-056","1R01AI150897-01","NIAID:586607\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ANN ARBOR","UNITED STATES","ANATOMY/CELL BIOLOGY","12","073133571","US","1506502","UNIVERSITY OF MICHIGAN AT ANN ARBOR","MI","481091276","Narrative High-risk human papillomaviruses (HPVs) cause essentially all cancers of the uterine cervix, as well as many other anogenital and oropharyngeal cancers. Despite the availability of highly effective prophylactic vaccines against HPV infection, cancers associated with HPV infection remain a major disease burden due to the limited use of the vaccine and the absence of vaccine benefit in people with current HPV infection. As elucidating the cellular basis of HPV infection may reveal valuable new strategies to combat HPV infection, in this proposal we propose to clarify a critical entry step during HPV infection.","1871265; 8022214 (contact); ","DIMAIO, DANIEL C; TSAI, BILLY  (contact);","NATARAJAN, RAMYA","03/24/2020","02/28/2025","Address; Anogenital cancer; Antiviral Agents; base; Binding; Biochemical; burden of illness; Capsid; Capsid Proteins; Cell Nucleus; Cell physiology; Cells; Cellular biology; combat; Complex; Cytoplasm; DNA Viruses; Endocytosis; endosome membrane; Endosomes; Event; experimental study; Foundations; gamma secretase; Golgi Apparatus; Golgi Targeting; Grant; high risk; Human; Human papilloma virus infection; Human Papillomavirus; human pathogen; improved; In Vitro; Individual; Infection; Infection prevention; insight; Integral Membrane Protein; Integration Host Factors; intracellular protein transport; L2 viral capsid protein; Light; Malignant neoplasm of cervix uteri; Malignant Neoplasms; malignant oropharynx neoplasm; Mass Spectrum Analysis; Mediating; Membrane; Minor; Molecular; Molecular Chaperones; Molecular Conformation; mutant; Mutation; N-terminal; novel; novel therapeutic intervention; Pathway interactions; Peptide Hydrolases; Peptides; Play; prevent; Preventive vaccine; Process; protein complex; Proteins; Proteomics; Publishing; receptor; reconstitution; recruit; Research Personnel; Role; Route; Testing; trafficking; trans-Golgi Network; Transmembrane Domain; Vaccines; Viral; Viral Genome; Virion; virology; Virus; ","Mechanism of gamma-secretase action during HPV infection","150897","VIRB","Virology - B Study Section ","","","01","460967","125640","586607",""
"9939710","U54","MD","5","N","03/18/2020","02/01/2020","01/31/2021","","U54MD007597","","RFA-MD-17-006","5U54MD007597-32","NIMHD:556748\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","WASHINGTON","UNITED STATES","","98","056282296","US","3499801","HOWARD UNIVERSITY","DC","200590005","","2064409; ","SOUTHERLAND, WILLIAM M;","","","","Area; Behavioral Research; Behavioral Sciences; Bioinformatics; Biomedical Research; Clinical Research; Clinical Sciences; Communities; Computational Biology; Core Facility; Data; Development; Effectiveness; Evaluation; Faculty; Feedback; Funding; Funding Agency; Grant; health disparity; Image; Individual; Infrastructure; Institution; minority health; Outcomes Research; Pilot Projects; Productivity; Proteomics; Public Health Informatics; Publications; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Informatics; Resources; Services; Structure; Universities; user-friendly; ","Research Infrastructure Core (RIC)","007597","ZMD1","Special Emphasis Panel ","5946","","32","436904","241654","","556748"
"9939714","U54","MD","5","N","03/18/2020","02/01/2020","01/31/2021","","U54MD007597","","RFA-MD-17-006","5U54MD007597-32","NIMHD:193071\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","WASHINGTON","UNITED STATES","","98","056282296","US","3499801","HOWARD UNIVERSITY","DC","200590005","","1892955; ","WILLIAMS, CARLA D;","","","","Address; Advisory Committees; Applications Grants; Area; base; Behavioral; Behavioral Research; Biomedical Research; Capital; career development; Client; Clinical; Clinical Research; Collaborations; Color; Communities; community based participatory research; Community Developments; Community Health Aides; Community Networks; community organizations; Data; Decision Making; design; Development; Diabetes Mellitus; Disease; disparity reduction; dissemination research; District of Columbia; Economics; Education; Employment; Ethnic Origin; experience; Feedback; food insecurity; Fostering; Funding; General Population; Goals; Grant; Health; health disparity; Health Promotion; Heart Diseases; Homicide; Housing; improved; Income; Individual; Infant Mortality; innovation; Knowledge; Leadership; literacy; Literature; Malignant Neoplasms; Measurable; Measures; Medical; member; Mental Health; metropolitan; minority health; novel; Outcome; Participant; Persons; physical conditioning; Pilot Projects; Policies; Politics; Population; Poverty; programs; Race; rapid growth; recruit; Reporting; Research; research data dissemination; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Research Support; research to practice; Resources; Role; Scientific Inquiry; Scientist; Self Management; Services; Sexually Transmitted Diseases; social; social health determinants; social structure; Socioeconomic Status; Structure; Tobacco use; Training; Translating; Universities; Work; ","Community Engagement Core (CEC)","007597","ZMD1","Special Emphasis Panel ","5948","","32","151512","83800","","193071"
"9941934","R25","TW","2","N","03/25/2020","03/26/2020","12/31/2020","989","R25TW009730","","PAR-19-244","2R25TW009730-06","FIC:244793\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","KAMPALA","UGANDA","","","850536636","UG","793001","MAKERERE UNIVERSITY","","7062","NARRATIVE The proposed program will develop a sustainable, model master?s degree program in international research ethics based at a strengthened Bioethics Center at Makerere University to produce graduates with potential to become bioethics leaders. Bioethics will become a significant part of their career participating in education of the next generation of bioethicists, design and implementation of high-quality ethical health research, conduct bioethics research, and provide expert advice to researchers, and policy makers. The success of this program will translate into improvements in ethical decision making for research leading to enhancements in responsible conduct of research, and overall protection of research participants.","8670745; ","SEWANKAMBO, NELSON K;","SINA, BARBARA J","05/01/2014","12/31/2025","Achievement; Address; Admission activity; Advisory Committees; Africa; Africa South of the Sahara; African; Applied Research; Attention; Award; base; behavioral health; Bioethics; Bioethics Consultants; career; Clinical; Collaborations; college; Consultations; cost; Country; Decision Making; Degree program; design; Development; Doctor of Philosophy; Economic Development; Education; Educational Background; Educational Curriculum; Empirical Research; Ensure; Environment; Ethical Issues; Ethics; experience; Faculty; flexibility; Foundations; Funding; Goals; Grant; Growth; Guidelines; Health; Health Sciences; improved; Indigenous; Industry; innovation; Institution; International; Journals; Knowledge; Leadership; leadership development; Life; life-long learning; low and middle-income countries; Master's Degree; Mentors; Mentorship; Modeling; Nature; Nerve; next generation; Occupations; Participant; Peer Review; Policies; Policy Developments; Policy Maker; Postdoctoral Fellow; Process; programs; public health research; Publishing; Research; Research Ethics; Research Personnel; Research Project Grants; Resources; responsible research conduct; service delivery; Service provision; Services; skills; social; social culture; socioeconomics; Students; success; Training; Training and Education; Training Programs; Translating; Uganda; United States National Institutes of Health; Universities; Work; ","SUSTAIN: Advancing Makerere University Masters of Health Sciences in Bioethics","009730","ZRG1","Special Emphasis Panel ","","","06","229490","15303","244793",""
"9986025","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007590","","RFA-MD-18-012","5U54MD007590-33","NIMHD:242027\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","ATLANTA","UNITED STATES","","05","065325177","US","2189101","CLARK ATLANTA UNIVERSITY","GA","303144358","Narrative The incidence of prostate cancer is 1.6 and the mortality rate is ~ 2.5 times higher in African-American men when compared to Caucasian men. The reasons for this increased risk for African-American men could be due to inherent biological differences and/or socio-economic reasons. Combined strategies based on basic biological research and community outreach programs are required to combat this disease in the African- American community. The proposed Research Centers in Minority Institutions (RCMI) program, Community Engagement and Dissemination (CED) core will combine both strengths of CCRTD and create an infrastructure for development of constant interactions between various communities with the focus on the development of the best practices for the elimination of prostate cancer health disparities. We will expand upon CCRTD?s current community-based organizations, i.e., schools, churches, ministerial alliances, advocacy groups, etc. to create an environment where the lay and scientific community come together to have mutual dialogue and interaction about cancer research being conducted in laboratories of CCRTD investigators. We will create an environment where the lay community influences all phases of the research. This aim will utilize the Community Engagement Health Inequity Seminar Series, pilot projects and several media outlets within the Atlanta metropolitan area to have the lay community contribute to basic research being conducted in CCRTD laboratories.","10099039; ","DAVIS, KIMBERLY E.;","","","","Academia; Address; Advocacy; Advocate; Affect; African American; anticancer research; Area; Awareness; base; Basic Science; Biological; biological research; Cancer Burden; cancer health disparity; Caucasians; Cellular biology; Church; combat; Communication; Communities; Community Health Education; Community Outreach; Community Participation; community partnership; Decision Making; Development; Disease; disparity reduction; Education; Education and Outreach; Ensure; Environment; Focus Groups; Fostering; Goals; Health; health disparity; Health education; Health Promotion; improved; Incidence; Information Dissemination; infrastructure development; insight; Journals; Knowledge; Laboratories; laboratory development; Malignant neoplasm of prostate; member; men; metropolitan; Minority; Minority-Serving Institution; Molecular Biology; mortality; NCI Center for Cancer Research; novel; Outcome; outreach; outreach program; patient registry; Phase; Pilot Projects; Play; Population; Population Group; Program Development; program dissemination; programs; Prostate; prostate cancer cell; Public Health; Recommendation; Research; Research Activity; research and development; Research Personnel; Research Training; Risk; Role; Schools; Scientist; Series; socioeconomics; symposium; therapeutic development; Time; Trust; Underrepresented Populations; Universities; ","Community Engagement Core","007590","ZMD1","Special Emphasis Panel ","8341","","33","157210","84893","","242027"
"9988918","R00","MH","5","N","03/25/2020","03/01/2020","02/28/2021","242","R00MH108700","","PA-15-083","5R00MH108700-04","NIMH:243608\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","RICHARDSON","UNITED STATES","","32","800188161","US","578409","UNIVERSITY OF TEXAS DALLAS","TX","750803021","PROJECT NARRATIVE The quality of the early social communication environment in infancy has significant implications for later development in children with autism spectrum disorder (ASD). I aim to explore the protective effects of the early social communication environment on brain and behavior development during infancy, a period of time before many of the diagnostic features of ASD have emerged and when the brain is capable of immense plasticity. Understanding the brain mechanisms underlying environment-behavior associations elucidates the mechanism behind aberrant development and potentially identifies targets for intervention.","11906363; ","SWANSON, MEGHAN RAE;","GILOTTY, LISA","08/02/2016","02/28/2022","Adult; Affect; autism spectrum disorder; autistic children; Award; base; Behavior; Behavioral; behavioral outcome; Birth; Brain; brain behavior; Brain imaging; career; career development; Child; cognitive development; Communication; Computational algorithm; computer science; Data; Development; Diagnosis; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Early Intervention; Environment; Equation; Feedback; Fiber; Gene Expression; Genetic Risk; Goals; high risk; Hippocampus (Brain); Home environment; Image; Image Analysis; imaging study; Individual Differences; infancy; Infant; Infant Development; Influentials; insight; Institutes; Instruction; Intervention; Language; Life; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Mental Health; Mentors; Mentorship; Modeling; multidisciplinary; Multimodal Imaging; neural circuit; neurodevelopment; neuroimaging; novel; Outcome; Parents; Pattern; Pattern Recognition; Phase; Population; Positioning Attribute; Predisposition; Production; protective effect; protective factors; Psychiatry; Research; Research Project Grants; Research Training; Risk; Rodent; Sampling; Schools; Siblings; skills; social; social communication; Social Interaction; Speech; Structure; Symptoms; Techniques; Testing; Time; Training; Universities; vocalization; ","Early Social Communication Environment and Brain Development in Infants at Risk for Autism","108700","ZMH1","Special Emphasis Panel ","","","04","180577","63031","243608",""
"10110116","R00","HD","4","N","03/24/2020","03/24/2020","02/28/2021","865","R00HD096051","SCHOOLS OF VETERINARY MEDICINE","PA-16-193","4R00HD096051-02","NICHD:249001\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","MADISON","UNITED STATES","BIOLOGY","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","Project Narrative: Appropriate formation of the female reproductive tract is the first critical step in determining women?s reproductive health. The proposed study will elucidate unexpected roles of a novel mesenchymal cell population in female reproductive tract formation. These studies will provide entry point to understand reproductive tract defects and diseases associated with perturbed mesenchymal differentiation.","15138139; ","ZHAO, FEI ;","TAYMANS, SUSAN","03/24/2020","02/28/2023","Ablation; Adult; Affect; Androgens; apoAI regulatory protein-1; base; Biological Process; Candidate Disease Gene; Cells; chicken ovalbumin upstream promoter-transcription factor; ChIP-seq; Defect; Development; Diagnosis; differential expression; Disease; Embryo; Excision; Female; fetal; Future; Gene Expression; Genes; Human; Individual; Infertility; Knock-out; Lead; Life Cycle Stages; Live Birth; male; Mammalian Oviducts; Men's Role; Mentors; Mesenchymal; Mesenchymal Differentiation; Mesenchyme; Modeling; Molecular; next generation sequencing; novel; Nucleic Acid Regulatory Sequences; Organ; Phase; Play; Population; Prevention; Process; Publishing; Regulation; Reproductive Health; reproductive tract; Role; Science; sex development disorder; single cell sequencing; Source; spatiotemporal; Syndrome; System; Testing; Tissues; Training; transcription factor; Uterus; Vagina; Woman; ","Unexpected roles of the male tract mesenchyme in female reproductive tract formation","096051","NSS","Special Emphasis Panel ","","","02","171291","77710","249001",""
"10124979","K23","MD","7","N","03/23/2020","03/23/2020","04/30/2020","307","K23MD014164","","PA-18-590","7K23MD014164-02","NIMHD:144837\","OTHER RESEARCH-RELATED","2019","National Institute on Minority Health and Health Disparities","","NEW YORK","UNITED STATES","","13","079683257","US","10041176","GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY","NY","100274516","PROJECT NARRATIVE African American (AA) women are overwhelmingly physically inactive and suffer disproportionately from associated health conditions, including type II diabetes, coronary heart disease, and obesity. Smartphone applications technology provides a substantial opportunity to deliver evidenced-based behavioral interventions tailored for AA women and help to promote adherence to physical activity.","14180907; ","SILLICE, MARIE ALINE;","TABOR, DERRICK C","08/15/2019","04/30/2024","","Developing a Tailored, Theoretically-Driven Smartphone Physical Activity Intervention for African American Women","014164","ZMD1","Special Emphasis Panel ","","","02","135237","9600","144837",""
"10132465","IK2","VA","7","N","03/25/2020","10/01/2019","06/30/2020","999","IK2BX003804","","RFA-BX-16-008","7IK2BX003804-04","","OTHERS","2019","Veterans Affairs","","SALISBURY","UNITED STATES","","13","023298611","US","481066","W G HEFNER VA MEDICAL CENTER","NC","281442515","More than 5 million Americans, including nearly 600,000 Veterans, are suffering with Alzheimer's disease. As a chronic, progressive disorder that lasts up to 20 years and costs $200 billion annually, this is a socioeconomic health problem requiring immediate attention. Veterans are especially vulnerable; the physical trauma and psychological stress common to their duty increases their Alzheimer's disease risk. Even Veterans who have spent little or no time fighting in recent wars have a higher incidence of dementia than civilians. The aim of this project is to 1) explore the role of a chronic stress pathway in the brain of Alzheimer's disease mice 2) conduct pre-clinical studies using a new therapeutic approach to target this pathway and 3) acquire scientific and professional mentorship from leading VA researchers and join their talented team. The expected outcome is an advance toward improving the health and wellbeing of Veterans and their families.    ","8961421; ","ORR, MIRANDA ETHEL;","","07/01/2017","06/30/2022","","Alzheimer?s disease-associated tau toxicity induces cellular senescence in the brain.","003804","NURD","Neurobiology D ","","","04","","","",""
"9792304","U24","NS","5","N","03/23/2020","02/29/2020","02/28/2021","853","U24NS109102","SCHOOLS OF ARTS AND SCIENCES","RFA-NS-18-005","5U24NS109102-02","NINDS:1262202\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","CAMBRIDGE","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","05","082359691","US","3212901","HARVARD UNIVERSITY","MA","021385319","This project provides neuroscientists with access to high quality volumetric electron microscopy data on the parts of the nervous system they study. Our goal is to provide the training and technologies so that neural circuit and cellular analysis of the nervous system are available to neuroscientists who seek data about neuronal circuits at the level of synapses (i.e., the nano- scale) and/or need to classify neuronal and other cell types in normal or diseased brain tissue or organoids. This project addresses the first high priority goal of the Brain 2025 report to the Director of the NIH.","8328640; ","LICHTMAN, JEFF W;","CAPORELLO, EMILY LAURA","09/30/2018","02/29/2024","Address; Brain; Brain Diseases; brain tissue; cell type; Cells; Communities; Computer Assisted; Computer software; Data; Data Set; Devices; Educational workshop; Electron Microscope; Electron Microscopy; Electron Microscopy Facility; Electronic Mail; Environment; Esthetics; Fees; Funding; Goals; Heavy Metals; Human Resources; Image; instrument; interest; Intuition; Journals; Laboratories; Learning; Maps; Methods; Microtome - medical device; Minor; nanoscale; Nervous System Physiology; Nervous system structure; neural circuit; Neuroglia; neuronal circuitry; Neurons; Neurosciences; new technology; Organoids; outreach; Persons; Plant Resins; Positioning Attribute; Process; Production; Property; Publications; Reporting; Research Personnel; Resolution; Resources; Roentgen Rays; sample fixation; Scanning; Scheme; Services; Silicon; Site Visit; Speed; Stains; Structure; symposium; Synapses; Techniques; Technology; Thinness; tissue preparation; Tissue Sample; Tissues; tool; Training; United States National Institutes of Health; Voice; Work; X-Ray Computed Tomography; ","A Facility to Generate Connectomics Information","109102","ZNS1","Special Emphasis Panel ","","","02","746865","515337","1262202",""
"9841179","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:85599\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE The focus of University of Kentucky Superfund Research Center (UK-SRC) is committed to developing an in- depth understanding of environmental health associated with exposure to organic pollutants as well as the development of protective technologies to aid in reduction of such exposure incidents. The proposed interdisiplinary training activites of the UK-SRC will be led and coordinated by the Research Experience and Training Coordination Core to successfully train skilled individuals who will positively impact our environmental health and the overall health of our nation.","8239234; ","HILT, JAMES ZACH;","","","","Address; Affect; base; Bioinformatics; career; career development; Clinical; Clinical Sciences; Collaborations; Communities; Complex; Data Analyses; Data Collection; data management; Data Science; data sharing; design; Development; Discipline; Doctor of Philosophy; Ecology; Education; Educational workshop; Environmental Engineering technology; Environmental Health; experience; Exposure to; flexibility; Funding; Goals; Government; Grant; Health; Individual; Industrialization; Industry; innovation; interdisciplinary approach; Interdisciplinary Study; interest; Kentucky; Knowledge; laboratory experience; Laboratory Research; Leadership; Life Style; Location; Medical Ethics; meetings; Mentors; Methods; Mind; Modeling; Modernization; multidisciplinary; next generation; novel; nutrition; Outcome; outreach; Policies; pollutant; Positioning Attribute; Postdoctoral Fellow; Problem Solving; Productivity; programs; Public Health; Recording of previous events; recruit; remediation; Reporting; Research; Research Project Grants; Resources; responsible research conduct; Science, Technology, Engineering and Mathematics; Scientist; Series; Signal Recognition Particle; skills; skills training; Social Impacts; Source; STEM field; student training; Students; success; Superfund; superfund chemical; superfund site; Technology; Thinking; Toxic effect; Toxicology; Training; Training Activity; Training and Education; training opportunity; Training Programs; Translational Research; Universities; Water; webinar; Writing; ","Research Experience and Training Coordination Core","007380","ZES1","Special Emphasis Panel ","5739","","22","59034","26565","","85599"
"9850493","I01","VA","5","N","03/24/2020","01/01/2020","12/31/2020","999","I01RX002783","","RFA-RX-18-003","5I01RX002783-02","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","MATHER","UNITED STATES","","07","127349889","US","10019212","VA NORTHERN CALIFORNIA HEALTH CARE SYS","CA","956554200","The long-term personal and economic costs of stroke with respect to disability are enormous. Despite efforts to mitigate these costs through stroke rehabilitation, all too often recovery after stroke remains partial, and many patients do not respond to traditional therapies, especially with respect to higher cognitive functions. These treatment failures arise for at least two reasons: complexities in adequately matching specific therapies to specific patients, and the need for new treatments to complement those that currently exist. Using new neuroimaging technologies and analysis techniques, we will evaluate behavioral and MRI testing shortly after stroke, and again at longer time periods, to identify markers that predict recovery in individual patients. In addition to permitting prospective validation of any predictors that we identify, these results will hopefully also form the basis for the assessment of new and individualized approaches to stroke treatment in the future. ","1952647; ","KAYSER, ANDREW S;","","01/01/2019","12/31/2022","Acute; Address; analytical method; base; behavior measurement; Behavioral; Blood Vessels; Brain; Brain region; California; Caring; Chronic; Cognition; Cognitive; cognitive control; Cognitive deficits; cognitive disability; cognitive function; cognitive recovery; Communities; Complement; Computing Methodologies; cost; Data; Decision Making; Dependence; design; Development; Diffusion; disability; economic cost; Emotional; Etiology; Event; Evolution; Functional Magnetic Resonance Imaging; Future; graph theory; Hospitals; Image; Impairment; improved; indexing; individual patient; Informed Consent; Injury; innovation; Lead; Lesion; Magnetic Resonance Imaging; Marshal; Measures; Methodology; Motor; Nervous System Physiology; network dysfunction; neuroimaging; neurological recovery; Neurologist; novel strategies; Occupational; Outcome; Patients; personalized approach; Pharmaceutical Preparations; Phenotype; post stroke; predictive marker; programs; prospective; Recovery; Recovery of Function; recruit; Rehabilitation Centers; Rehabilitation therapy; Resources; Rest; Scanning; Science; Sentinel; Site; Speech; Statistical Methods; stem; Stroke; stroke event; stroke outcome; stroke patient; stroke recovery; stroke rehabilitation; stroke therapy; Structure; System; Techniques; Technology; Testing; Time; tractography; traditional therapy; Treatment Failure; Validation; Veterans; Work; ","Developing Behavioral and Neuroimaging Predictors of Stroke Recovery","002783","RRD1","Brain Health & Injury ","","","02","","","",""
"9853827","R01","HD","5","N","03/25/2020","02/01/2020","01/31/2021","865","R01HD065340","SCHOOLS OF MEDICINE","PA-13-302","5R01HD065340-09","NICHD:435632\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","SEATTLE","UNITED STATES","PHYSICAL MEDICINE & REHAB","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","Project Narrative  Valid, reliable, and efficient measurement of relevant health outcomes is needed to facilitate improvements in clinical care, research, and quality-of-life for people with lower limb amputation. Development of novel, performance-based instruments using modern measurement theory will enable researchers to more effectively study health outcomes and interventions intended to address functional impairments, activity limitations, and participation restrictions present among people with limb amputation. Application of developed measures using adaptive computer technologies will allow clinicians to efficiently evaluate patients' health outcomes, select interventions best suited to each individual patient, and provide high quality, evidence-based care.","8585952; ","HAFNER, BRIAN J;","QUATRANO, LOUIS A","06/01/2010","01/31/2022","Address; Advocate; Affect; Age; Algorithms; Amputation; base; Caring; Characteristics; Client; Clinical; Clinical assessments; clinical care; clinical practice; community reintegration; Computer software; computerized; Computers; Cross-Sectional Studies; Development; Diabetes Mellitus; effective therapy; Electronic Health Record; Elements; Eligibility Determination; Ensure; Equilibrium; Etiology; Evaluation; Event; evidence base; experience; functional disability; functional independence; Goals; Health; Impairment; improved; Individual; individual patient; innovation; instrument; Intervention; Knee Prosthesis; Lead; Length; Life; limb amputation; Limb Prosthesis; Lower Extremity; Measurement; Measures; Methods; Modeling; Modernization; Motivation; novel; Outcome; Outcome Measure; Participant; Patient Care; patient mobility; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Performance; Physical Function; Population; Positioning Attribute; Professional Practice; Property; Prosthesis; prosthetic foot; Psychometrics; Quality of Care; Quality of life; recruit; Rehabilitation therapy; Reporting; Research; Research Personnel; research study; response; Sampling; simulation; Standardization; Structure; System; Task Performances; Techniques; Technology; Testing; theories; Therapeutic Intervention; Third-Party Payer; Time; time use; tool; United States; Validity and Reliability; Walking; Work; ","A Client-Based Outcome System for Individuals with Lower Limb Amputation","065340","CHHD","Biobehavioral and Behavioral Sciences Subcommittee ","","","09","366490","69142","435632",""
"9857601","F30","DK","5","N","02/18/2020","03/26/2020","03/25/2021","847","F30DK116529","SCHOOLS OF MEDICINE","PA-16-306","5F30DK116529-03","NIDDK:39424\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","DETROIT","UNITED STATES","GENETICS","13","001962224","US","9110501","WAYNE STATE UNIVERSITY","MI","482024050","PROJECT NARRATIVE The proposed research investigates the role of ABHD5 interaction with PNPLA3 in maintaining lipid homeostasis in the liver and the mechanism of how the I148M variant of PNPLA3 perturbs this homeostasis leading to increased fat accumulation in the liver. Fat accumulation in the liver is the first stage of fatty liver disease and increases risk of cirrhosis. The long term goal of this research is to better understand the regulation of lipid homeostasis in the liver and the pathogenesis and development of fatty liver disease.","14880127; ","YANG, ALEXANDER C;","DENSMORE, CHRISTINE L","03/26/2018","03/25/2023","Acyl Coenzyme A; Adipose tissue; Adult; Affect; Affinity; Allosteric Regulation; base; Binding; Biological Assay; career; Cirrhosis; clinically relevant; combat; Complement; Data; Development; driving force; Endoplasmic Reticulum; Enzymes; Equilibrium; experience; Family member; Fasting; Fatty acid glycerol esters; Fatty Liver; gain of function; Genes; genome wide association study; genome-wide analysis; Goals; Health; Health Priorities; Hepatic; Hepatocyte; Histologic; Homeostasis; Human; Hydrolase; Hydrolysis; Imaging Techniques; Immunoprecipitation; In Vitro; in vivo; inducible gene expression; Kinetics; Knowledge; Lead; Ligand Binding; Ligands; Ligation; Link; Lipase; lipid metabolism; Lipids; Lipolysis; Liver; Liver diseases; Liver Extract; Liver Failure; Metabolic Diseases; Modeling; Molecular; molecular imaging; Mus; non-alcoholic fatty liver disease; novel; Nutritional; Nutritional status; overexpression; Pathogenesis; Pharmacology; Phospholipase; Physicians; Predisposition; prevent; protein protein interaction; Proteins; Regulation; Reporting; Research; Risk; Role; Scientist; stoichiometry; Structure; Testing; tool; trafficking; Triglycerides; United States; Variant; ","ABHD5 and PNPLA3 in the development of fatty liver disease","116529","ZDK1","Special Emphasis Panel ","","","03","39424","","39424",""
"9858281","R01","CA","5","N","03/26/2020","02/01/2020","01/31/2021","394","R01CA154475","SCHOOLS OF MEDICINE","PA-18-484","5R01CA154475-07","NCI:577621\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","DALLAS","UNITED STATES","RADIATION-DIAGNOSTIC/ONCOLOGY","30","800771545","US","578404","UT SOUTHWESTERN MEDICAL CENTER","TX","753909105","Project Narrative The aim of the proposed research is to investigate the correlation between in vivo magnetic resonance imaging (MRI) measures of cellularity, blood flow and fat accumulation with the recently discovered molecular alterations in the angiogenic and lipogenic pathways that are associated to aggressive behavior in clear cell renal cell carcinoma (RCC). Quantitative measures of cellularity, blood flow and fat fraction will be obtained with diffusion weighted imaging (DWI), arterial spin labeling (ASL) and Dixon-based MRI techniques, respectively.","9176603; ","PEDROSA, IVAN ;","MENKENS, ANNE E","09/15/2011","01/31/2024","3D Print; Age; Aggressive behavior; American; Amino Acids; angiogenesis; base; Behavior; bHLH-PAS factor HLF; Biological; Biological Markers; Biology; Biopsy; Blood; Blood flow; Blood Vessels; CD34 gene; Cellularity; Cessation of life; Clear Cell; Clear cell renal cell carcinoma; Clinical Management; clinical practice; Collaborations; Comorbidity; Data; density; Development; Diffusion Magnetic Resonance Imaging; Enzymes; experience; Fatty acid glycerol esters; Fatty Acids; Fatty-acid synthase; Funding; Gene Expression Profiling; Genotype; Glucose; Glycogen; Guidelines; Hepatic; Heterogeneity; Histologic; Human; hypoxia inducible factor 1; Image; imaging biomarker; imaging modality; Imaging Techniques; Immunohistochemistry; in vivo; Incidence; Indolent; inhibitor/antagonist; Kidney; Kidney Neoplasms; lipid biosynthesis; lipid metabolism; Lipids; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measurement; Measures; Metabolic; metabolic phenotype; metabolic profile; metabolomics; Molds; Molecular; Natural History; Neoplasm Metastasis; Nephrectomy; Oils; outcome forecast; overexpression; overtreatment; Pathologic; Pathway interactions; Patients; Perfusion; Physiological; predicting response; predictive marker; prognostic value; Progression-Free Survivals; protein expression; Protocols documentation; Renal Cell Carcinoma; Renal Mass; Reporting; Research; response; Risk; Role; Signal Transduction; Specimen; Spin Labels; Stearoyl-CoA Desaturase; success; Surface; Techniques; Testing; Texture; The Cancer Genome Atlas; therapeutic target; Tissue Sample; Tissues; transcription factor; tumor; Tumor Angiogenesis; Tumor Biology; tumor heterogeneity; tumor metabolism; tumor progression; two-dimensional; Unnecessary Surgery; Up-Regulation; urologic; Variant; Vascular Endothelial Growth Factors; VHL Gene Inactivation; Xenograft procedure; ","NON-INVASIVE PHYSIOLOGIC PREDICTORS OF AGGRESSIVENESS IN RENAL CELL CARCINOMA","154475","MEDI","Medical Imaging Study Section ","","","07","356556","221065","577621",""
"9858312","R01","CA","5","N","03/26/2020","03/01/2020","02/28/2021","396","R01CA212376","SCHOOLS OF MEDICINE","PA-16-160","5R01CA212376-04","NCI:527107\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","NEW HAVEN","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","03","043207562","US","9420201","YALE UNIVERSITY","CT","065208327","As cancer threatens to become the number one cause of mortality in this nation, immune checkpoint inhibitors, a new class of immunotherapy agents, have emerged as a powerful weapon against this disease. Immune checkpoint inhibitors remove naturally occurring brakes in immune cells, thereby improving the ability of the body?s own immune system to recognize and destroy cancer cells. Here we propose to target a novel immune checkpoint that is present within innate immune cells, our first line of immune defense, and to understand the molecular processes that enhance the anti-cancer immune response upon inhibition its function as well as its association with human disease.","9825696; 10165013 (contact); ","GHOSH, SOURAV ; ROTHLIN, CARLA  (contact);","MCCARTHY, SUSAN A","03/01/2017","02/28/2022","Ablation; Acute; adaptive immunity; anti-cancer; anti-tumor immune response; Antigen Presentation; Antitumor Response; Apoptotic; base; beta catenin; biomarker panel; Breast Cancer Model; cancer cell; cancer genetics; cancer immunotherapy; Cancer Model; cancer prevention; cancer therapy; Cell physiology; Cells; checkpoint therapy; Colon Carcinoma; comparative efficacy; Complement; Data; Defect; Defense Mechanisms; Dendritic cell activation; Dendritic Cells; Development; Diagnosis; Disabled Persons; Disease; Drug usage; Excision; Failure; FDA approved; fighting; Future; Genetic; Genetically Engineered Mouse; Growth; Human; human disease; Immune; immune checkpoint; immune checkpoint blockade; Immune checkpoint inhibitor; Immune response; Immune signaling; Immune system; Immunotherapeutic agent; Immunotherapy; improved; improved functioning; Individual; inhibitor/antagonist; Innate Immune System; Interferon Type I; Interferons; Knock-in Mouse; Knock-out; Knockout Mice; Lead; loss of function; Lymphoma; macrophage; Malignant Neoplasms; MC38; Measures; Mediating; melanoma; MERTK gene; Modeling; Molecular; molecular targeted therapies; mortality; mouse model; Mus; Names; Natural Immunity; neutralizing antibody; novel; patient subsets; Patients; Phagocytosis; Phosphorylation; Phosphotransferases; pre-clinical; predictive marker; Process; Protein Tyrosine Kinase; Proteins; Receptor Protein-Tyrosine Kinases; Regulation; Reporting; Resistance; response; Sampling; sensor; Signal Pathway; Signal Transduction; small molecule; Specimen; Stains; T cell response; T-Cell Activation; T-Lymphocyte; targeted treatment; Testing; Therapeutic Uses; tumor; tumor growth; Tumor Immunity; Tumor-associated macrophages; Tumor-infiltrating immune cells; Tumor-Infiltrating Lymphocytes; weapons; ","An innate immune checkpoint in cancer immunotherapy","212376","CII","Cancer Immunopathology and Immunotherapy Study Section ","","","04","314691","212416","527107",""
"9862942","R01","DK","1","N","03/23/2020","03/23/2020","01/31/2021","847","R01DK123252","SCHOOLS OF MEDICINE","PA-19-056","1R01DK123252-01","NIDDK:398289\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","PHILADELPHIA","UNITED STATES","PHYSIOLOGY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Project Narrative The goal of this proposal is to define the molecular mechanisms that underlie the metabolic actions of insulin on skeletal muscle with the goal of elucidating new signaling mechanisms that contribute to metabolic disease. Specifically, this project will examine the role of AKT, a serine/threonine kinase, in the regulation of glucose metabolism and skeletal muscle growth by insulin.","11703374; ","TITCHENELL, PAUL MICHAEL;","SILVA, CORINNE M","03/23/2020","01/31/2025","Address; adenylate kinase; Affect; Aging; Anabolism; Automobile Driving; Biochemical; blood glucose regulation; carbohydrate metabolism; Carbohydrates; Cardiovascular Diseases; Cardiovascular system; Clinical; Data; Defect; Development; Diabetes Mellitus; diabetic; Disease; Disuse Atrophy; Effectiveness; Event; Exhibits; experimental study; FOXO1A gene; Functional disorder; Genetic; genetic manipulation; Glucose; glucose disposal; Glucose Intolerance; glucose metabolism; glucose uptake; Goals; Growth; Homeostasis; Hormones; Human; Hyperglycemia; improved; in vivo; Individual; Insulin; insulin mediators; Insulin Resistance; insulin sensitivity; insulin signaling; Insulin Signaling Pathway; interest; Investigation; Isotope Labeling; Knowledge; Measures; Mediating; Medical; Metabolic; Metabolic Control; Metabolic Diseases; metabolomics; Mitochondria; mitochondrial dysfunction; Modeling; Molecular; molecular modeling; Molecular Target; Mus; Muscle; muscle form; Muscle function; Muscle Mitochondria; Muscle Proteins; Muscular Atrophy; new therapeutic target; Non-Insulin-Dependent Diabetes Mellitus; novel therapeutics; Organ; Pathway interactions; Performance; Pharmacology; phosphoproteomics; Phosphotransferases; Pilot Projects; Play; preservation; Protein Biosynthesis; protein degradation; protein metabolism; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Regulation; Research; restoration; Role; Signal Pathway; Signal Transduction; Skeletal Muscle; skeletal muscle growth; skeletal muscle metabolism; skeletal muscle wasting; stem; Techniques; Testing; Therapeutic Intervention; Time; Treatment Efficacy; uptake; wasting; ","Regulation of Skeletal Muscle Metabolism by Insulin Signaling","123252","MCE","Molecular and Cellular Endocrinology Study Section ","","","01","250000","148289","398289",""
"9867674","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:128514\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Animal Model; Biometry; Budgets; Cancer Center; Cancer Center Support Grant; cancer therapy; Catchment Area; Charge; Clinical; clinical investigation; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Colorado; data management; design; Detection; Development; Devices; Diagnosis; Disease; early phase trial; Early Therapeutic-Clinical Trials Network; Eligibility Determination; Ensure; Funding; Funding Mechanisms; Future; Goals; Immunotherapy; Incubators; Industry; Infrastructure; innovation; Institutes; Intervention Trial; Investigational Therapies; investigator-initiated trial; Malignant Neoplasms; meetings; member; multidisciplinary; National Clinical Trials Network; novel; Outcome; Patients; Peer Review; Peer Review Grants; Phase; Pilot Projects; pre-clinical; prevent; Prevention; Process; programs; protocol development; racial and ethnic; Research; research clinical testing; Research Design; Research Personnel; Research Support; Resistance; Resources; Review Committee; Running; Science; Scientist; socioeconomics; statistics; Structure; targeted agent; Testing; Translating; Translational Research; Underserved Population; Universities; ","Early Phase Clinical Research Support","046934","NCI","Subcommittee H - Clinical Groups ","5071","","32","82977","45537","","128514"
"9867675","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:68807\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Animal Cancer Model; animal imaging; Apoptosis; Area; Arts; Autophagocytosis; Award; Basic Science; Bioinformatics; Biological Markers; Biological Models; Biological Process; biological systems; Biology; Biometry; Cancer Biology; cancer cell; Cancer Center Support Grant; cancer chemoprevention; cancer genomics; Cancer Model; Cancer Patient; cancer prevention; cancer stem cell; cell behavior; Cell Cycle; Cell Cycle Regulation; Cells; Cellular biology; Centrosome; Chemopreventive Agent; Clinic; Clinical; clinical application; clinical investigation; Clinical Research; Clinical Trials; Collaborations; college; Colorado; Defect; Dental Schools; design; Development; Developmental Biology; Diagnosis; diagnostic biomarker; Discipline; Disease; DNA biosynthesis; DNA damage checkpoint; Doctor of Philosophy; Experimental Models; Faculty; Fishes; Flow Cytometry; Fostering; Foundations; functional genomics; fundamental research; Funding; Future; Generations; Genetic Transcription; Genomics; Goals; graduate student; Grant; Human; Immune; Immune Evasion; Immunology; Immunotherapy; improved; innovation; Institution; Investigation; Joints; Journals; Knowledge; Lead; Leadership; Malignant Neoplasms; malignant phenotype; Maps; Matrix Metalloproteinases; Medicine; meetings; member; Mentors; Mission; Molecular; Molecular Genetics; molecular pathology; multidisciplinary; Mus; Nematoda; Neoplasm Metastasis; new technology; Normal Cell; novel; novel diagnostics; novel therapeutics; outcome forecast; Pathway interactions; Patients; Peer Review; Physicians; Prevention strategy; Privatization; Process; Production; Productivity; Prognostic Marker; programs; Proteins; Public Health Schools; Publications; Publishing; Regulation; Research; Research Design; Research Peer Review; Research Project Grants; Resource Sharing; Resources; Science; Scientist; Signal Transduction; Site; Stem cells; student mentoring; Students; success; System; targeted treatment; technological innovation; Technology; Testing; Therapeutic Intervention; therapeutic target; Training; Training Programs; Translating; translational study; tumor microenvironment; tumor progression; Universities; Xenograft Model; Yeasts; Zebrafish; ","Cancer Cell Biology Program","046934","NCI","Subcommittee H - Clinical Groups ","5072","","32","44580","24227","","68807"
"9867679","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:71335\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Address; Adolescent; Adult; Age; anticancer research; Area; Automobile Driving; base; Basic Science; Bioenergetics; Bioinformatics; Biological; Biology; Biometry; Cancer Center Support Grant; cancer stem cell; Catchment Area; Cell physiology; Characteristics; Childhood; Clinical; clinical investigation; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorado; Communities; companion animal; Complement; design; Development; Disease model; Disease Progression; Doctor of Philosophy; Epigenetic Process; epigenetic regulation; epigenome; Erythrocytes; ETV6 gene; European; Event; Flow Cytometry; Fostering; functional genomics; Funding; Future; Genes; Genets; Genomics; Germ-Line Mutation; Goals; Grant; Growth; Hematologic Neoplasms; Hematology; Hematopoietic Neoplasms; Human; Immunology; Immunotherapeutic agent; Immunotherapy; improved; Institution; interdisciplinary collaboration; Interdisciplinary Study; Investigation; Investigational Therapies; investigator-initiated trial; Jordan; Laboratories; Laboratory Research; Leadership; leukemia; Leukemic Cell; Lymphoblastic Leukemia; Malignant Neoplasms; malignant state; Medicine; meetings; member; Mentors; metabolic abnormality assessment; Metabolism; metabolomics; Mitochondria; Modeling; Molecular; Molecular Biology; Molecular Chaperones; Monitor; mouse model; multidisciplinary; Multiple Myeloma; Mus; Normal Cell; novel; novel therapeutics; oncology; Pathway interactions; Patients; Pediatric Hematology; Peer Review; Periodicity; personalized medicine; Pharmacology; Physiology; Play; Population; Positioning Attribute; pre-clinical; Predisposition; Prevention; Production; programs; Property; Publications; recruit; Regimen; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Role; Signal Transduction; Specimen; Talents; targeted agent; targeted treatment; Technology; Testing; Therapeutic; Therapeutic Intervention; Thrombocytopenia; Training; Translating; translational scientist; translational study; tumor; Universities; Vision; Work; young adult; ","Hematologic Malignancies Program","046934","NCI","Subcommittee H - Clinical Groups ","5075","","32","46206","25129","","71335"
"9867682","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:71335\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Adoption; Affect; animal imaging; Architecture; Area; Basic Science; Biochemistry; Bioinformatics; Biology; biomedical informatics; Biometry; Cancer Biology; cancer cell; Cancer Center; Cancer Center Support Grant; Cancer Diagnostics; cancer prevention; cancer therapy; cancer type; Cells; Chromatin; Chromosomal Rearrangement; Chromosome abnormality; Clinical; Clinical Research; Clinical Trials; Collaborations; Colorado; Cryoelectron Microscopy; Dependence; design; Diagnosis; DNA Damage; DNA Repair; Down Syndrome; Epigenetic Process; epigenetic regulation; Event; Evolution; experience; Flow Cytometry; functional genomics; Funding; Future; Gap Junctions; Gene Expression; Gene Expression Profile; Genes; Genomics; Goals; Grant; HIF1A gene; Homeostasis; Human; Hypoxia; improved; Institutes; Institution; interdisciplinary collaboration; Intervention; Investigation; investigator-initiated trial; Lead; Leadership; Link; Macromolecular Complexes; Malignant Neoplasms; Mediator of activation protein; member; Metabolic; metabolomics; Mission; Molecular; Molecular Chaperones; Molecular Mechanisms of Action; molecular oncology; molecular pathology; Molecular Structure; multidisciplinary; Multiprotein Complexes; Mutagens; Mutation; new technology; novel; novel strategies; novel therapeutic intervention; novel therapeutics; Nuclear Magnetic Resonance; Oncogenes; Oncogenic; oncology program; Pathology; Pathway interactions; Periodicity; personalized medicine; Pharmacology; phosphoproteomics; Phosphotransferases; Post-Transcriptional Regulation; pre-clinical; prevent; Prevention therapy; Process; Production; prognostic value; programs; promoter; Proteins; Proteomics; Publications; Publishing; repaired; Research; Research Peer Review; Research Personnel; Research Project Grants; Resistance; Resource Sharing; Resources; response; RNA; RNA Polymerase II; Scientific Advances and Accomplishments; Signal Pathway; Signal Transduction; Site; skills; Structural Biologist; structural biology; Structural Protein; Surface; targeted treatment; Technology; Telomerase; telomere; Telomere Maintenance; Telomere Pathway; Therapeutic; tissue culture; tool; transcription factor; Transcriptional Regulation; Translational Research; translational scientist; Translations; tumor; tumor progression; Tumor Suppressor Proteins; Universities; Work; X-Ray Crystallography; ","Molecular Oncology Program","046934","NCI","Subcommittee H - Clinical Groups ","5077","","32","46206","25129","","71335"
"9867747","R01","MH","5","N","03/25/2020","03/01/2020","02/28/2021","242","R01MH110358","SCHOOLS OF PUBLIC HEALTH","PA-13-248","5R01MH110358-04","NIMH:675256\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BALTIMORE","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","The World Health Organization, UNAIDS, and the White House National HIV/AIDS Strategy have collectively called for the need to reduce stigma towards MSM as a vital component of an effective HIV response. Consistent and validated measures of sexual behavior stigma are needed in the context of multiple intersecting stigmas; therefore, the proposed research project will develop, test, and validate sexual behavior stigma metrics using existing and ongoing data collected across Sub-Saharan Africa and the United States. Using bio- specimens collected in the American Men's Internet Survey, the proposed project will additionally contribute to the understanding of relationships between stigma and risk for chronic stress and sexually transmitted infections among this key population.","9297516; ","BARAL, STEFAN DAVID;","GREENWOOD, GREGORY","05/05/2017","02/28/2022","Address; Affect; Africa South of the Sahara; African; AIDS prevention; AIDS/HIV problem; Alcohol consumption; American; base; Biological Markers; care systems; Caring; Categories; Chlamydia; Chronic stress; Collaborations; comparative; Data; Data Analyses; Data Set; Development; DNA; Equation; Ethnic Origin; experience; Factor Analysis; Future; Gender; Goals; Gonorrhea; health disparity; Health Services Accessibility; Healthcare; High Prevalence; HIV; HIV Infections; HIV prevention trials network; HIV risk; HIV Seropositivity; HIV/STD; Home environment; Incidence; International; Internet; intersectionality; Intervention; Length; Measurement; Measures; Mediating; Mediator of activation protein; men; men who have sex with men; Mental Depression; Mental Health; Methods; Michigan; Modeling; Outcome; Participant; Pathway interactions; Population; Population Programs; Prevention; prevention service; Public Health Schools; Race; Recommendation; recruit; rectal; Research Personnel; Research Priority; Research Project Grants; response; Risk; Saliva; sex; Sex Behavior; Sexual Health; sexual role; Sexually Transmitted Diseases; social stigma; Specimen; Stress; Structure; Surveys; telomere; Testing; therapy development; transmission process; Treatment outcome; treatment services; United States; United States National Institutes of Health; Universities; uptake; Urine; Ursidae Family; Validation; Validity and Reliability; Viral Load result; Work; World Health Organization; ","Validation of Stigma Metrics for Marginalized Men ","110358","BSPH","Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section ","","","04","525166","150090","675256",""
"9868286","R01","CA","5","N","03/26/2020","03/01/2020","02/28/2021","395","R01CA225615","SCHOOLS OF NURSING","PA-16-160","5R01CA225615-03","NCI:618491\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","TUCSON","UNITED STATES","NONE","03","806345617","US","490201","UNIVERSITY OF ARIZONA","AZ","857210158","Project Narrative This research focuses on the management of persisting symptoms that cancer survivors experience following the completion of chemotherapy. Even after treatment has ended, many survivors experience persistent fatigue, pain, depression, anxiety, insomnia, and other symptoms. This project will test two interventions to alleviate these symptoms among survivors who have elevated depressive symptoms and co-morbid illnesses and have high need for symptom management in the immediate post-chemotherapy period.","1957002 (contact); 8583810; ","BADGER, TERRY A (contact); SIKORSKII, ALLA ;","LEE, CECILIA H","03/01/2018","02/28/2022","active method; Address; Aftercare; American; Anxiety; Attention; base; Behavior; Belief; Benchmarking; Cancer Survivor; cancer therapy; Characteristics; chemotherapy; Clinical; clinical Diagnosis; Cognitive; Comorbidity; Counseling; depressive symptoms; design; Diagnosis; Emotional; Enrollment; ethnic diversity; evidence base; experience; Fatigue; Future; Goals; Heterogeneity; Hispanics; indexing; Individual; innovation; Intervention; intervention effect; Logic; Malignant Neoplasms; Mediating; Mental Depression; Morbidity - disease rate; mortality; Outcome; Pain; Participant; persistent symptom; preference; primary outcome; Quality of life; Randomized; randomized trial; Reaction Time; Recurrence; reduce symptoms; Research; Resolution; response; Risk; Sampling; secondary outcome; Self Care; Self Efficacy; Severities; Sleeplessness; Social support; Solid Neoplasm; success; Sum; Survivors; survivorship; symptom management; symptom self management; symptomatology; Symptoms; Telephone; Testing; Time; treatment duration; trial design; virtual; Work; ","Post-chemotherapy Symptom Management: Testing Intervention Sequences in a SMART Design","225615","ZRG1","Special Emphasis Panel ","","","03","402926","215565","618491",""
"9869917","R01","NS","5","N","03/27/2020","03/01/2020","02/28/2021","853","R01NS078494","SCHOOLS OF MEDICINE","PA-16-160","5R01NS078494-08","NINDS:388139\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","LOS ANGELES","UNITED STATES","NEUROSURGERY","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","Project Narrative  Cervical spondylotic myelopathy (CSM) is a form of chronic spinal cord injury caused by degenerative spine disease, and is the most common acquired cause of spinal cord dysfunction in adults. The neurological recovery and clinical response from both surgical and nonsurgical treatment can be quite variable and inconsistent. The proposed study will use advanced brain and spinal cord imaging techniques to assess abnormalities within the central nervous system found in these patients, and determine the ability of these techniques to predict and monitor response to surgical and nonsurgical treatment.","8834308; 8641750 (contact); ","ELLINGSON, BENJAMIN M.; HOLLY, LANGSTON TYLER (contact);","BAMBRICK, LINDA LOUISE","09/26/2012","02/28/2023","Adult; Age-Years; Anatomy; Anisotropy; Area; Atrophic; base; Biochemistry; Biological Assay; Biological Markers; Brain; Cell physiology; cerebral atrophy; Cerebrum; Cervical; Cervical spinal cord structure; Cervical spine; Chronic; Clinical; Complex; Corticospinal Tracts; Diffuse; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Functional disorder; Functional Magnetic Resonance Imaging; Funding; Goals; Imaging Techniques; Impairment; Individual; intervertebral disk degeneration; knowledge base; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Metabolic; Metabolism; Monitor; Motor; Multimodal Imaging; Neck Pain; Nervous System Physiology; Neuraxis; neuroimaging; Neurologic; neurological recovery; Neuronal Plasticity; normal aging; Operative Surgical Procedures; outcome forecast; Pain; Pathogenesis; Patients; postoperative recovery; preservation; Process; Recovery; relating to nervous system; Research; response; Rest; Role; Running; Societies; spectroscopic imaging; Spinal; Spinal Cord; Spinal Cord Diseases; spinal cord imaging; Spinal cord injury; Spondylosis; Structure; surgery outcome; Techniques; Thick; Treatment Cost; Vertebral column; Work; ","Spinal and Cerebral biomarkers for measuring disease progression and prognosis in chronic spinal cord injury","078494","ZRG1","Special Emphasis Panel ","","","08","275231","112908","388139",""
"9876519","R21","AI","1","N","03/23/2020","03/23/2020","02/28/2021","855","R21AI149383","BIOMED ENGR/COL ENGR/ENGR STA","PA-19-053","1R21AI149383-01","NIAID:188438\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","COLLEGE STATION","UNITED STATES","ENGINEERING (ALL TYPES)","17","847205572","US","8266919","TEXAS ENGINEERING EXPERIMENT STATION","TX","778433577","PROJECT NARRATIVE  Tuberculosis (TB) causes approximately 9 million new cases and 1.5 million deaths every year, and the emergence of multidrug and extensively drug resistant TB is a major public health threat. The proposed research uses novel engineering tools to design targeted liposomal antibiotics for the treatment of Mycobacterium tuberculosis infection. The success of this work will lead to a novel instrument that allows researchers to design drug delivery systems for nearly any disease target in a highly accessible, flexible, and inexpensive manner.","1889380; 12001069 (contact); ","CIRILLO, JEFFREY D.; WU, HUNG-JEN  (contact);","BOYCE, JIM P","03/23/2020","02/28/2022","Address; Adherence; Affinity; Alveolar Macrophages; Antibiotic Therapy; Antibiotics; Antibodies; Antigens; antimicrobial; Antitubercular Agents; Avidity; base; Binding; Biological Assay; biomaterial compatibility; cancer therapy; Cessation of life; combat; Combined Modality Therapy; Control Groups; Defense Mechanisms; design; Disease; Dissociation; Dose; Drug Carriers; Drug Delivery Systems; Drug Design; drug development; drug efficacy; Drug Kinetics; Drug resistance; Drug Targeting; Encapsulated; Engineering; Ensure; Equilibrium; Extreme drug resistant tuberculosis; flexibility; Formulation; Future; Goals; immunogenic; In Vitro; in vivo; in vivo evaluation; instrument; Lateral; Libraries; Ligand Binding; Ligands; liposome vector; Liposomes; Liquid substance; Literature; macrophage; Measurement; Measures; Membrane; Membrane Fluidity; Methods; Motion; Mycobacterium tuberculosis; Nature; novel; novel therapeutics; Outcome; pathogen; Phagocytosis; Pharmaceutical Preparations; Polysaccharides; Process; Proteins; Public Health; receptor; receptor binding; Reporting; Research; Research Personnel; resistant strain; Rifampin; screening; sensor; success; Surface; Surveys; targeted delivery; Testing; Therapeutic; therapy duration; Tissues; tool; Tuberculosis; tuberculosis drugs; tuberculosis treatment; two-dimensional; uptake; Work; ","Design of hetero-multivalent targeted liposome for combating intracellular Mycobacterium tuberculosis","149383","GDD","Gene and Drug Delivery Systems Study Section ","","","01","125000","63438","188438",""
"9878138","R01","NS","5","N","03/25/2020","02/01/2020","01/31/2021","853","R01NS065926","SCH ALLIED HEALTH PROFESSIONS","PA-18-484","5R01NS065926-10","NINDS:537341\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","RICHARDSON","UNITED STATES","NONE","32","800188161","US","578409","UNIVERSITY OF TEXAS DALLAS","TX","750803021","Our work is aimed at gaining a better understanding of molecular events that drive neuropathic pain and then using this knowledge to identify new molecular targets for neuropathic pain treatment. Our work has found a key signaling pathway that regulates nociceptor excitability changes that occur in neuropathic pain. An exciting aspect of this discovery is that this signaling pathway can be targeted by drugs that are in phase II clinical trials. The combined use of pharmacology, genetics and next generation sequencing technologies in our project will give new insight into mechanisms of neuropathic pain and will identify novel therapeutic opportunities to treat this highly prevalent and exceedingly difficult to manage neurological disorder","6579040; ","PRICE, THEODORE J;","OSHINSKY, MICHAEL L","03/15/2010","01/31/2024","Acute; adaptive immune response; Afferent Neurons; Affinity Chromatography; Automobile Driving; base; Behavioral; behavioral plasticity; Binding; Brain-Derived Neurotrophic Factor; cell type; chronic pain; Data; Development; Down-Regulation; Drug Targeting; Electrophysiology (science); Event; experimental study; Gene Expression; Generations; Genes; Genetic; Genetic Translation; Hypersensitivity; Inflammation Mediators; Inflammatory; inhibitor/antagonist; Injury; insight; Interleukin-10; interleukin-10 receptor; Knock-out; Knockout Mice; Knowledge; Laboratories; LoxP-flanked allele; Mechanics; Mediating; Messenger RNA; Mitogen-Activated Protein Kinases; Modeling; Molecular; Molecular Target; Mus; Mutation; nervous system disorder; Neuronal Plasticity; Neurons; Neuropathy; new therapeutic target; next generation sequencing; Nociception; Nociceptors; novel therapeutics; p38 Mitogen Activated Protein Kinase; Pain; Pain management; pain model; painful neuropathy; Pathway interactions; Peptide Initiation Factors; Peripheral nerve injury; Persistent pain; Pharmacology; Phase II Clinical Trials; Phenotype; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Population; pre-clinical; protein expression; Protein Isoforms; Proteins; receptor; Regulation; Regulatory Pathway; response; Ribosomes; RNA Caps; Role; Signal Pathway; Signal Transduction; Site; Spinal Ganglia; Stimulus; Synapses; Technology; Testing; Therapeutic; therapeutic target; Transgenic Mice; Translating; translation factor; Translation Initiation; Translations; translatome; tumorigenesis; Up-Regulation; Work; ","Translation Control of Pain Plasticity","065926","ZRG1","Special Emphasis Panel ","","","10","396929","140412","537341",""
"9880397","R01","AR","5","N","03/23/2020","03/01/2020","02/28/2021","846","R01AR075421","","PA-18-484","5R01AR075421-02","NIAMS:364625\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Project Narrative The function of the largest organ in the human body, the skin is dependent on the ability of skin progenitor cell to continuously self-renew and regenerates various tissue components. Although various molecular mechanisms have been implicated in the control of skin progenitor cell function the precise nature of these processes is not yet understood. We have uncovered a novel signaling pathway functioning as ?guardian? of the skin progenitor cells, which preserves their ability to regenerate. Therefore we are now proposing to further study this molecular pathway and offer insights into a new modality of stem cell control and currently unexplored opportunities for outside interventions of defective wound healing and skin regeneration.","10419279; 8664153 (contact); ","HSU, YA-CHIEH ; MANDINOVA, ANNA  (contact);","TSENG, HUNG H","03/01/2019","02/29/2024","3' Untranslated Regions; Ablation; Acute; Adult; Affect; Aging; Anabolism; Architecture; Artificial Organs; Binding; Binding Proteins; Biochemical; Biological; Cell Aging; Cell Death; Cell Lineage; Cell physiology; Cells; Coupled; CXCL1 gene; CXCL2 gene; cytokine; Cytokine Signaling; Data; Defect; Development; DNA binding protein B; Epidermis; Epigenetic Process; Epithelium; Equilibrium; Genetic; Genetic Transcription; Gold; Guide RNA; Homeostasis; Human; Human body; human model; IL8 gene; Impairment; in utero; In Vitro; in vivo; Injections; Injury; insight; Intervention; keratinocyte; Laboratories; loss of function; Mediating; Messenger RNA; Metabolism; Modality; Modeling; Molecular; Mus; Natural regeneration; Nature; Normal tissue morphology; novel; novel therapeutic intervention; Organ; Organ Model; Pathway interactions; Pharmacology; Phenotype; Phosphorylation; Phosphotransferases; Population; Positioning Attribute; Post-Transcriptional Regulation; Post-Translational Protein Processing; preservation; prevent; Prevention; Process; Production; progenitor; Proliferating; Proteins; Proteome; PTGS2 gene; Publishing; regenerative; Regulation; response; response to injury; Ribosomes; Risk; Role; self-renewal; senescence; Signal Pathway; Skin; skin disorder; Skin injury; skin regeneration; Skin wound; stem cell division; Stem cells; Stratified Squamous Epithelium; Stratum Basale; Stress; Subfamily lentivirinae; Testing; Therapeutic Intervention; Thick; Time; tissue regeneration; tissue repair; Tissues; Translations; Work; Wound Healing; ","Posttranscriptional control of epidermal progenitors senescence","075421","ZRG1","Special Emphasis Panel ","","","02","268576","96049","364625",""
"9703469","P01","AG","2","N","03/25/2020","04/01/2019","03/31/2020","","P01AG014449","","PAR-18-297","2P01AG014449-22","NIA:401342\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","PHOENIX","UNITED STATES","","07","131606022","US","2052813","ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER","AZ","850134409","","2183135; ","MUFSON, ELLIOTT JAY;","","","","Advisory Committees; Agreement; Alzheimer's Disease; Alzheimer's Disease Core Center; Biocompatible Materials; Blinded; brain tissue; Budgets; Clinical; Communication; Consensus; Data; data management; Dementia; Discipline; Doctor of Philosophy; Drug or chemical Tissue Distribution; Elderly; Ensure; Exercise; Freezing; Funding; Funding Agency; Future; Goals; Harvest; Individual; Institutes; Institution; Laboratory Research; Leadership; Medical center; meetings; member; Michigan; mid-career faculty; mild cognitive impairment; Molecular; Neurobiology; Neurologic; neuropathology; New York; Persons; Positioning Attribute; Program Research Project Grants; programs; Progress Reports; Protocols documentation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Sampling; Scientist; Site; Specimen; statistics; Structure; symposium; Universities; Update; web page; web site; Work; ","Core A-Administrative and Tissue Distribution","014449","ZAG1","Special Emphasis Panel ","7794","","22","279987","121355","","401342"
"9841180","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:226500\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE This project explores connections between two major public health concerns that are highly relevant to Superfund Research Program (SRP) stakeholders and the SRP: widespread contamination of the environment by a class of long-lasting toxic chemical contaminants known as PCBs and PFAS. These contaminants have been linked to a leading U.S. health challenge, cardiovascular diseases, and also linked to the liver and gut. The project addresses specifically SRP Mandate 4 by testing dietary interventions that may disrupt disease processes by stabilizing the gut bacteria and liver and reducing cardiovascular risks initiated by exposure to pollutants, particularly in people who reside near Superfund or other hazardous waste sites where PCBs and other pollutants are prevalent.","1897514; ","HENNIG, BERNHARD ;","","","","Acute; Address; animal data; Animal Model; Antibiotics; Atherosclerosis; atherosclerosis risk; base; Binding; biobank; Biological; Biological Markers; Blood Vessels; body system; cardiometabolism; Cardiovascular Diseases; cardiovascular disorder risk; cardiovascular risk factor; Cause of Death; Ceramides; chemical stability; Chemicals; choline deficient diet; Chronic; Data; Data Set; Development; Diet; Dietary Fiber; Dietary Intervention; Dioxins; Disease; disorder risk; Down-Regulation; Ecology; Endothelium; Environment; Environmental Engineering technology; Environmental Exposure; Enzymes; Epigallocatechin Gallate; Event; experimental study; exposed human population; Exposure to; Fiber; Functional disorder; Future; Gene Expression; Genes; Goals; Green tea; gut bacteria; gut microbiota; Hazardous Waste Sites; Health; Hepatic; Hepatocyte; Human; In Vitro; in vivo; Inflammation; Inflammatory; Insulin Resistance; Inulin; Link; lipid metabolism; Lipids; Liver; Liver Dysfunction; liver injury; Low Density Lipoprotein Receptor; macrophage; Mediating; Metabolic; Metabolic dysfunction; metabolic profile; Metabolism; metabolomics; Methionine; Modeling; Molecular; Mus; NF-kappa B; Nutrient; nutrition; Outcome; oxidation; Oxidation-Reduction; Pathology; Peripheral; Permeability; persistent organic pollutants; Plants; Plasma; Poison; pollutant; Polychlorinated Biphenyls; polyphenol; Population; Pre-Clinical Model; prebiotics; prevent; Process; Production; programs; Public Health; Reporting; Research; Resistance development; response; Risk; Sampling; Signal Pathway; Signal Transduction; Sphingolipids; stable isotope; Stains; Superfund; superfund chemical; Technology; Testing; Toxic effect; toxicant; transcriptomics; trimethyloxamine; United States; Vascular Endothelial Cell; vascular inflammation; Volatile Fatty Acids; ","Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk","007380","ZES1","Special Emphasis Panel ","5740","","22","156207","70293","","226500"
"9850841","R01","NR","2","N","03/24/2020","03/24/2020","12/31/2020","361","R01NR013497","SCHOOLS OF MEDICINE","PA-18-140","2R01NR013497-06A1","NINR:491157\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","HOUSTON","UNITED STATES","PEDIATRICS","09","051113330","US","481201","BAYLOR COLLEGE OF MEDICINE","TX","770303411","PROJECT NARRATIVE Abdominal pain-related functional gastrointestinal disorders affect 10-20% of children and adults worldwide exerting a tremendous economic, social, and emotional burden. There is a critical need to understand what factors contribute to pain in these disorders so that effective management and treatment strategies can be designed. The results of this proposal will provide insight into the factors responsible for abdominal pain symptoms to allow better patient-specific treatment.","7354342; ","SHULMAN, ROBERT ;","TULLY, LOIS","09/27/2012","12/31/2024","16S ribosomal RNA sequencing; Abdominal Pain; Adult; Affect; base; Bayesian Modeling; Behavioral; Bioinformatics; Biological Markers; Caring; Characteristics; Child; Childhood; Clinical Research; Data; Databases; design; Diagnosis; diaries; Diet therapy; Dietary Factors; Disease; Distress; dysbiosis; Economics; Emotional; enteric infection; Evaluation; Feces; Functional disorder; Functional Gastrointestinal Disorders; Funding; Gastroenterologist; Genes; Goals; gut microbiome; Impairment; Individual; individual patient; Inflammation; Inflammatory disease of the intestine; innovation; insight; Irritable Bowel Syndrome; Link; Mediating; Metabolic Pathway; metabolomics; Metagenomics; metaproteomics; Methodology; microbial; microbial community; microbiome; microbiome research; Modeling; multidisciplinary; Neuroimmune; novel; Nurse Practitioners; Oranges; Outcome Measure; Pain; pain symptom; Pathogenesis; Patients; Pattern; Pediatric Hospitals; Permeability; Pharmacotherapy; Phenotype; Physiology; Precision Medicine Initiative; Productivity; prospective; psychosocial; Public Health; Publishing; Quality of life; Questionnaires; Recurrence; Reporting; Research; Resolution; Schools; Shotguns; social; specific biomarkers; stool sample; supervised learning; symptom science; Symptoms; Technology; Texas; Therapeutic; therapeutic target; treatment strategy; United States National Institutes of Health; Virulence Factors; whole genome; Whole-Genome Shotgun Sequencing; Work; ","PATHWAYS TO NEW BIOMARKERS IN RECURRENT ABDOMINAL PAIN IN CHILDREN","013497","NRCS","Nursing and Related Clinical Sciences Study Section ","","A1","06","317211","173946","491157",""
"9853535","P20","GM","1","N","03/24/2020","12/01/2019","11/30/2020","","P20GM130418","","PAR-18-266","1P20GM130418-01A1","NIGMS:212652\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MISSOULA","UNITED STATES","","00","010379790","US","1381006","UNIVERSITY OF MONTANA","MT","598124104","","15469372; ","NEWCOMER, SOPHIA RAFF;","","","","Address; Age; Area; Attitude; base; Censuses; Cessation of life; Child; Childhood; Chronic; Clinic; Communities; Data; Disease; disorder risk; Dose; early childhood; Education; experience; Family Practice; Future; Geographic Distribution; Geography; Goals; Health; Health Resources; Healthy People 2020; Home environment; Hospitalization; Hot Spot; Immunization; improved; Individual; Information Systems; Intervention; Life; Measles; Medical; Medically Underserved Area; Methods; Modeling; Montana; motivational enhancement therapy; National Institute of Allergy and Infectious Disease; novel; Parents; Perception; Pertussis; Population; Prevalence; Prevention Research; programs; Provider; Public Health; public health intervention; Records; recruit; Risk Factors; Rural; rural area; Rural Population; Scanning; Series; social media; Structure; Surveys; System; Testing; Time; tool; Transportation; uptake; urban area; urban disparity; Vaccination; Vaccines; Visit; Work; ","Project 3: Investigating barriers to timely early childhood vaccination in Montana","130418","ZGM1","Special Emphasis Panel ","7783","A1","01","148808","63844","","212652"
"9859351","R01","CA","5","N","03/27/2020","02/01/2020","01/31/2021","393","R01CA207689","SCHOOLS OF ARTS AND SCIENCES","PA-13-292","5R01CA207689-04","NCI:788354\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","GAINESVILLE","UNITED STATES","MISCELLANEOUS","03","969663814","US","513806","UNIVERSITY OF FLORIDA","FL","326115500","PROJECT NARRATIVE A primary goal of Healthy People 2020 is to increase the percentage of individuals screened for colorectal cancer (CRC) across population subgroups to 80%. The proposed study will reduce health disparities and associated morbidity and mortality due to CRC by increasing FIT screening among racial/ethnic minorities and rural patients through a novel, culturally sensitive intervention.","9324070; ","RAUP-KRIEGER, JANICE LEE;","KOBRIN, SARAH","02/01/2017","01/31/2022","Adherence; Affect; aged; American; Appearance; Area; Attitude; base; Behavior; behavior change; Cancer Etiology; cancer health disparity; Cessation of life; Clinic; clinical data warehouse; Cognitive; Colonoscopy; Colorectal Cancer; colorectal cancer screening; Communication; Communities; computer science; Computers; Control Groups; cost; cost effective; Custom; Decision Making; efficacy testing; Electronic Health Record; Enrollment; ethnic minority population; Experimental Designs; Exposure to; falls; Focus Groups; Gender; General Population; Geography; Goals; Guidelines; health disparity; Health system; Healthcare Systems; Healthy People 2020; improved; Incidence; Individual; Informatics; Infrastructure; Intervention; Interview; Measures; meetings; Methods; Minority; Morbidity - disease rate; mortality; novel; Participant; patient engagement; patient oriented; patient population; Patient Preferences; Patient Recruitments; patient registry; Patient Self-Report; patient-level barriers; Patients; personalized screening; Population; Primary Health Care; Process; prototype; Public Health; Published Comment; racial and ethnic; Randomized; recruit; Research; Research Design; rural patients; Rural Population; scale up; screening; screening disparities; screening guidelines; Secure; Self Efficacy; Subgroup; Tablets; tailored messaging; Technology; Testing; Text; theories; therapy development; Treatment Efficacy; United States; uptake; usability; virtual human; virtual technology; web-enabled; ","A patient-centered intervention using virtual technology to reduce colorectal cancer disparities in primary care","207689","HDEP","Health Disparities and Equity Promotion Study Section ","","","04","563858","224496","788354",""
"9867676","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:71335\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Address; Affect; animal imaging; anticancer research; Basic Science; Behavior Therapy; Behavioral; behavioral health; Behavioral Research; Behavioral Sciences; biobank; Bioinformatics; Biological; Biological Models; Biostatistics Shared Resource; Breast Cancer Risk Factor; Cancer Burden; cancer care; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Cancer Model; Cancer Patient; cancer prevention; cancer risk; Cancer Survivor; Cancer Survivorship; cancer therapy; care delivery; Caregivers; Catchment Area; Chemoprevention; Clinic; Clinical; Clinical Trials; Collaborations; Colorado; Colorectal; Communities; Country; Decision Making; Development; Diagnosis; Discipline; dissemination research; Doctor of Philosophy; Early Diagnosis; Epidemiology; epidemiology study; Etiology; Face; Faculty; Flow Cytometry; Funding; Future; Genomics; Goals; Grant; Health; health care delivery; health disparity; Health Policy; Health Services; Health Services Research; Health system; Hispanics; Human; implementation research; improved; improved outcome; In Vitro; Institution; interdisciplinary approach; Investigation; Investments; Laboratories; Leadership; low socioeconomic status; malignant breast neoplasm; Malignant Neoplasms; Medical Informatics; medically underserved; member; Mentors; Mentorship; Methods; multidisciplinary; Obesity; Outcome; Patients; Peer Review; Physicians; Policies; Policy Research; Population; population health; Population Research; Population Sciences; preclinical study; prevent; Prevention; Prevention Research; prevention service; Preventive service; Primary Prevention; Production; programs; Proteins; psychologic; psychosocial; Publications; recruit; Recruitment Activity; Research; Research Activity; Research Personnel; Research Support; Resource Sharing; Resources; Risk; Risk Factors; Risk Reduction; Rodent; Schools; Scientist; Screening for cancer; screening program; Source; Survivors; survivorship; tissue culture; Tissues; Toxic effect; Training Programs; Translations; Treatment outcome; Universities; Woman; Work; ","Cancer Prevention and Control Program","046934","NCI","Subcommittee H - Clinical Groups ","5073","","32","46206","25129","","71335"
"9872186","R01","HL","5","N","03/27/2020","02/01/2020","01/31/2021","233","R01HL135483","SCHOOLS OF MEDICINE","PA-16-160","5R01HL135483-03","NHLBI:761077\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BALTIMORE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","PROJECT NARRATIVE Obstructive sleep apnea impairs breathing during sleep, and increases risks of diabetes and cardiovascular disease by unknown mechanisms. This proposal examines whether sleep apnea causes excessive free fatty acid (FFA) release during sleep, which can interfere with glucose homeostasis, vascular function and inflammation; and whether a drug that inhibits stress-induced FFA elevation (propranolol) can prevent these consequences. If this project is successful, therapies that block FFA release during sleep might protect against diabetes and cardiovascular disease in sleep apnea patients.","8741092; ","JUN, JONATHAN C.;","BROWN, MARISHKA","02/01/2018","01/01/2023","Adipose tissue; Adrenergic Agents; Adult; Affect; airway muscle; Animal Model; Atherosclerosis; Attention; base; blood glucose regulation; Blood Pressure; Blood specimen; Blood Vessels; body position; Breathing; cardiometabolic risk; cardiometabolism; Cardiovascular Diseases; Cessation of life; Chronic; Clinical Trials; Continuous Positive Airway Pressure; Cross-Over Studies; Diabetes Mellitus; diabetes risk; disability; Disease; Double-Blind Method; Dyslipidemias; Equilibrium; fatty acid oxidation; Functional disorder; Glucose; Glucose Intolerance; glucose tolerance; Health; Heart failure; Heart Rate; Hyperglycemia; Hyperlipidemia; Hypertension; Hypoxia; Impairment; Inflammation; Insulin Resistance; Knowledge; Laboratories; Lead; Link; Lipids; Lipolysis; Metabolic; metabolic abnormality assessment; Metabolic dysfunction; Metabolic syndrome; Metabolism; Modeling; Mus; Muscle Tonus; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; novel; Obesity; Obstructive Sleep Apnea; Outcome; Oxygen; Pathogenesis; Patient Noncompliance; patient stratification; Patients; Pharmaceutical Preparations; Pharmacology; Placebos; Plasma; prevent; Propranolol; Respiration Disorders; Risk; Risk Factors; Role; Sampling; Severities; Sleep; Sleep Apnea Syndromes; sleep onset; stable isotope; Stable Isotope Labeling; Statistical Data Interpretation; Stress; Sympathetic Nervous System; Techniques; Testing; Tracer; Triglycerides; Vascular Diseases; Withdrawal; ","Lipolysis during sleep and cardiometabolic consequences of sleep apnea","135483","CIDO","Clinical and Integrative Diabetes and Obesity Study Section ","","","03","502260","258817","761077",""
"9873068","R01","HL","5","N","03/23/2020","03/01/2020","02/28/2021","837","R01HL137748","SCHOOLS OF MEDICINE","PA-16-160","5R01HL137748-03","NHLBI:574543\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","MILWAUKEE","UNITED STATES","PHYSIOLOGY","05","937639060","US","46001","MEDICAL COLLEGE OF WISCONSIN","WI","532263548","PROJECT NARRATIVE Hypertension is a major cause of global mortality and a primary modifiable risk factor for renal, cardiovascular and cerebrovascular disease. In 50% of patients with essential hypertension, blood pressure increases in response to salt (salt-sensitivity). The present studies will address a significant knowledge gap by directly assessing the mechanisms mediating immune cell infiltration and activation in the kidney which amplify salt- sensitive hypertension.","8514599 (contact); 1912231; ","COWLEY, ALLEN W (contact); MATTSON, DAVID L.;","VARAGIC, JASMINA","05/01/2018","02/28/2022","Address; Adhesions; Attenuated; base; Blood Pressure; Blood Vessels; Bone Marrow; Cardiovascular Diseases; Cells; Cerebrovascular Disorders; Chronic; Custom; Dahl Hypertensive Rats; Data; design; Disease; DNA Sequence Alteration; effective therapy; Endothelium; Essential Hypertension; experimental study; Foundations; Gelatinase A; Gelatinase B; Genetic; genetic approach; Genetic Engineering; Health; Hematopoietic; high salt diet; Hydrogen Peroxide; Hypertension; Immune; Immune Cell Activation; Infiltration; Inflammasome; Inflammation; Injury; insight; Kidney; kidney cortex; Kidney Diseases; Knowledge; Laboratories; Left kidney; Leukocytes; Limb structure; Malignant Hypertension; Matrix Metalloproteinases; Mediating; Messenger RNA; Methodology; Methods; migration; Modeling; modifiable risk; Molecular; mortality; NADPH Oxidase; novel; null mutation; Pathology; Pathway interactions; Patients; Perfusion; Pharmacology; Phase; Play; pressure; prevent; Process; Production; Proteins; Rat Strains; Rattus; Reactive Oxygen Species; renal damage; Renal Hypertension; Renal Tissue; Research Proposals; response; Risk Factors; salt sensitive; salt sensitive hypertension; Sodium Chloride; Source; Sterility; Superoxides; System; T-Lymphocyte; Testing; Thick; Tissues; transcriptome sequencing; transcriptomics; Tubular formation; Tumor-infiltrating immune cells; Up-Regulation; Work; ","Mechanisms of renal immune cell infiltration in salt-sensitive hypertension","137748","HM","Hypertension and Microcirculation Study Section ","","","03","373080","201463","574543",""
"9873969","SC1","GM","5","N","03/24/2020","03/01/2020","02/28/2021","859","SC1GM121202","ORGANIZED RESEARCH UNITS","PAR-16-439","5SC1GM121202-02","NIGMS:358750\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","LOS ANGELES","UNITED STATES","NONE","44","785877408","US","489501","CHARLES R. DREW UNIVERSITY OF MED & SCI","CA","900593051","Project Narrative The proposed project is anticipated to provide a highly effective novel regimen through a combination of two natural non-toxic plant products with or without a synthetic drug to improve current chemoprevention and therapy in prostate cancer. This combination will counteract the tumor-stimulating signals of obesity in addition to targeting tumor itself thereby to enhance the preventive and therapeutic effect.","11262487; ","WANG, PIWEN ;","KRASNOVA, IRINA N","03/01/2019","02/28/2023","3T3-L1 Cells; Adenosine Monophosphate; Adipocytes; African American; androgen sensitive; Angiogenic Factor; anti-cancer; Anti-inflammatory; Antineoplastic Agents; arctigenin; base; Biological Availability; Blood; cancer cell; cancer chemoprevention; cancer health disparity; cancer prevention; cancer therapy; cancer type; CCL2 gene; Cells; chemokine; Chemoprevention; Chemopreventive Agent; Chronic Disease; clinical practice; Clinical Trials; Coculture Techniques; Colon Carcinoma; Colorectal Cancer; cost; cytokine; density; Development; Diabetes Mellitus; Diet; Dose; Epithelial; Fat-Restricted Diet; Fatty acid glycerol esters; FRAP1 gene; Goals; Greater Burdock; Green tea; Growth Factor; High Fat Diet; high risk; Human; Implant; improved; In Vitro; in vivo; Incidence; Individual; Inflammation; inhibitor/antagonist; Insulin-Like Growth Factor I; Knockout Mice; Lignans; Link; LNCaP; malignant breast neoplasm; Malignant neoplasm of prostate; Malignant Neoplasms; metastasis prevention; Modality; Modeling; Molecular; monocyte chemoattractant protein 1 receptor; Morbid Obesity; mortality disparity; mouse model; Mus; Natural Products; Nature; Neoplasm Metastasis; neoplastic cell; Non obese; Non-Insulin-Dependent Diabetes Mellitus; novel; Obese Mice; Obesity; Pathway interactions; Patients; Pharmaceutical Preparations; Phytochemical; Population; Premalignant; Prevention; Preventive; Prostate; prostate cancer cell; prostate cancer prevention; Prostate Cancer therapy; Prostatic Intraepithelial Neoplasias; Prostatic Neoplasms; protein expression; Protein Kinase; PTEN gene; Regimen; Resistance; Seeds; Severe Combined Immunodeficiency; side effect; Signal Pathway; Signal Transduction; success; synthetic drug; System; Testing; Therapeutic; Therapeutic Effect; Toxic effect; Transgenic Organisms; Treatment Failure; tumor; tumor growth; tumor progression; Tumor stage; Tumor Volume; tumor xenograft; Vascular Endothelial Growth Factors; Xenograft Model; Xenograft procedure; ","Co-targeting obesity in prostate cancer chemoprevention and therapy","121202","ZGM1","Special Emphasis Panel ","","","02","250000","108750","358750",""
"9882235","R25","CA","5","N","03/25/2020","03/01/2020","02/28/2021","398","R25CA203637","SCHOOLS OF MEDICINE","PAR-15-151","5R25CA203637-04","NCI:270037\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","LOUISVILLE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","03","057588857","US","4679701","UNIVERSITY OF LOUISVILLE","KY","402920001","Project Narrative (Relevance) Excellent care of patients diagnosed with cancer requires the integration of palliative care and the close collaboration of professionals from many disciplines including physicians, nurses, chaplains, and social workers. Through faculty development webinars, online modules and a train-the- trainer program, this project will train 160 health science educators to provide interprofessional education in oncology palliative care at 35- 50 institutions across the nation. As a result, students of the health sciences at these institutions will learn the skills and knowledge essential for providing effective team-based, patient-centered palliative oncology care.","9095094; 8126973 (contact); ","HEAD, BARBARA A; PFEIFER, MARK P (contact);","KORCZAK, JEANNETTE F","03/14/2017","02/28/2022","Accreditation; Address; base; cancer care; cancer diagnosis; cancer education; cancer palliative treatment; Cancer Patient; Caring; Collaborations; Communication; Complex; Crowding; design; Development; Diagnosis; Discipline; Discipline of Nursing; Education; Educational Activities; Educational Curriculum; Educational workshop; experience; Faculty; Future; Goals; health care service utilization; Health Sciences; improved; Infrastructure; Institution; instrument; interest; Knowledge; Lead; Learning Skill; Length; Logistics; Malignant Neoplasms; Medicine; Mentors; method development; Modeling; Nature; Nurses; oncology; Outcome; outcome forecast; palliative; Palliative Care; Patient Care; patient oriented; Patient-Centered Care; Patients; pedagogy; Physicians; practice setting; Pre-Post Tests; Program Sustainability; programs; Quality of life; Resources; Role; science teacher; Site; skills; Social Work; Social Workers; student training; Students; success; symposium; Teacher Professional Development; Time; Trainers Training; Training; Training Programs; webinar; Work; ","Training in Interprofessional Education for Palliative Care in Oncology","203637","NCI","Subcommittee H - Clinical Groups ","","","04","294015","23521","270037",""
"9883827","R01","HL","5","N","03/25/2020","03/01/2020","02/28/2021","838","R01HL125734","SCHOOLS OF MEDICINE","PA-13-302","5R01HL125734-05","NHLBI:688534\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","Aurora","UNITED STATES","INTERNAL MEDICINE/MEDICINE","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","PUBLIC HEALTH RELEVANCE: This project seeks to identify microRNAs that are associated with in utero smoke (IUS) exposure in the human lung that may be a biomarker for asthma susceptibility later in life. Identification of an integrative network of IUS exposure during human lung development, which includes genomic and epigenetic data, may identify microRNAs and pathways for novel therapies and targeted preventive strategies for asthma. Since asthma remains a leading cause of childhood hospitalizations, school absences, and missed days of work in the United States, both novel therapies and preventive strategies have the potential to substantially decrease the morbidity and financial burden related to asthma worldwide.","9579860; ","SHARMA, SUNITA ;","LACHOWICZ-SCROGGINS, MARRAH ELIZABETH","04/01/2016","02/28/2021","Affect; Age; Alveolar Macrophages; Animal Model; antenatal; Asthma; asthmatic; Bayesian Method; biobank; Biological; Biological Markers; Blood specimen; bronchial epithelium; Childhood; cohort; Data; Development; differential expression; Disease; DNA Methylation; early life exposure; early onset; epidemiologic data; Epigenetic Process; exposed human population; Exposure to; Expression Profiling; Fetal Lung; Financial Hardship; Gaussian model; Gene Expression; Genes; Genome; genome-wide; Genomic approach; Genomics; Health Expenditures; Hospitalization; Human; human fetal lung tissue; Human Genome; human subject; in utero; Knowledge; Lead; Life; Linear Models; Lung; lung development; MicroRNAs; miRNA expression profiling; Modeling; Morbidity - disease rate; Network-based; new therapeutic target; novel; novel therapeutics; Pathway Analysis; Pathway interactions; Pattern; Play; postnatal; Predisposition; prenatal; prenatal exposure; Prevention strategy; Public Health; public health relevance; Respiratory physiology; Reverse Transcriptase Polymerase Chain Reaction; Role; Sampling; Schools; Severity of illness; sex; Signal Transduction; Smoke; Testing; Therapeutic Agents; therapeutic target; Time; Tissue Sample; Tobacco smoke; Umbilical Cord Blood; United States; Vitamin D; Wheezing; Whole Blood; Work; ","MICRORNAS AND EARLY LIFE EXPOSURES IN THE DEVELOPMENTAL ORIGIN OF ASTHMA","125734","IRAP","Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section ","","","05","537679","150855","688534",""
"9886889","R01","HD","1","N","03/25/2020","03/25/2020","02/28/2021","865","R01HD100985","SCHOOLS OF MEDICINE","PA-19-056","1R01HD100985-01A1","NICHD:350262\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","HOUSTON","UNITED STATES","UROLOGY","09","051113330","US","481201","BAYLOR COLLEGE OF MEDICINE","TX","770303411","PROJECT NARRATIVE: Although birth defects of the genitourinary (GU) tract are common, the cause of such defects remains largely unknown. This study aims to understand the causes of common GU tract birth defects by identifying new genes that may play a role in development of the urinary tract.","12031192; ","SETH, ABHISHEK ;","TAYMANS, SUSAN","03/25/2020","02/28/2025","16p11.2; Actins; Affect; Androgen Receptor; Birth; Cell Line; cell motility; Complex; Congenital Abnormality; Copy Number Polymorphism; Critical Pathways; Cryptorchidism; CUL3 gene; Cytoskeleton; Data; Defect; design; Development; Diagnosis; Diagnostic; Disease; Essential Genes; Exhibits; experimental study; Feminization; Gametogenesis; Gene Dosage; Gene Targeting; Genes; Genetic; Genitalia; Genitourinary system; Germ Cells; Goals; gonad development; High Prevalence; Human; Hypospadias; In Vitro; in vitro Model; in vivo; Incidence; Individual; Intercellular Junctions; knock-down; Knockout Mice; Knowledge; Lead; Lesion; Link; Maintenance; male; Male Genital Organs; Malignant Neoplasms; Masculine; Mediating; Molecular; mouse model; mRNA Expression; Mus; Mutant Strains Mice; Mutation; Neurologic; Newborn Infant; overexpression; Pathway interactions; Patients; penis; Physiological; Play; Proteins; RBX1 gene; receptor expression; Receptor Signaling; Recovery; Regulation; RHOA gene; Risk; Role; Seminal Vesicles; sertoli cell; Sex Behavior; sex development disorder; Signal Transduction; subfertility; Testing; Testis; Tissues; tool; ubiquitin-protein ligase; Ubiquitination; Up-Regulation; Urinary tract; Urination; urogenital tract; Virilism; ","The Role of E3-Ubiquitin Ligase Complex in Genitourinary Tract Development and Function.","100985","KMBD","Kidney Molecular Biology and Genitourinary Organ Development ","","A1","01","221262","129000","350262",""
"9888367","R25","EB","5","N","03/26/2020","03/01/2020","02/28/2021","286","R25EB013070","BIOMED ENGR/COL ENGR/ENGR STA","PAR-13-111","5R25EB013070-10","NIBIB:21600\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","MILWAUKEE","UNITED STATES","BIOMEDICAL ENGINEERING","04","046929621","US","4833601","MARQUETTE UNIVERSITY","WI","532011881","PUBLIC HEALTH RELEVANCE: The proposed project will better prepare biomedical engineering graduates to identify unmet needs and opportunities for new products, translate and commercialize new product ideas, and produce more diverse and potentially better solutions through a multidisciplinary team approach. This can significantly impact public health through providing more students with the opportunity to work on senior design projects that address the needs of underserved populations (domestic and global) including people with disabilities, which could result in more biomedical engineering graduates seeking careers that allow them to address the needs of these groups.","10479627; ","GOLDBERG, JAY RICHARD;","ERIM, ZEYNEP","04/15/2011","02/28/2021","Address; Arthrogryposis; Arts; Back; base; Behavior; bench to bedside; Biomedical Engineering; Biomedical Technology; career; Caregivers; Client; Clinical; Collaborations; commercialization; Dentists; design; Development; Devices; Disabled Persons; Economics; Education; Educational Curriculum; engineering design; Environment; Ethical Issues; Ethics; experience; family support; Funding; Goals; Health; Health Benefit; Healthcare; Human Resources; improved; Industrialization; Industry; innovation; Institutes; Knowledge; laboratory equipment; Learning Module; Legal; Marketing; Medical Device; Medical Device Designs; medical schools; Medical Technology; meetings; member; Methods; Mission; multidisciplinary; National Institute of Biomedical Imaging and Bioengineering; new product development; novel; Nurses; open-ended problem; Paper; Patient Care Team; Patients; Phase; physical therapist; Physicians; Positioning Attribute; Preparation; Procedures; Process; product development; Production; programs; prototype; Provider; Public Health; public health relevance; Resources; Sales; Self-Help Devices; service learning; skills; social; Students; Support Groups; Surgeon; Thinness; three-dimensional modeling; Translating; undergraduate student; Underserved Population; United States; Universities; verification and validation; Wisconsin; Work; Workplace; ","Multidisciplinary Team-Based Design Education to Create Biomedical Engineering Innovators","013070","ZEB1","Special Emphasis Panel ","","","10","20000","1600","21600",""
"9889985","R01","HL","5","N","03/23/2020","03/01/2020","02/28/2021","837","R01HL141343","SCHOOLS OF MEDICINE","PA-18-484","5R01HL141343-02","NHLBI:571003\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LEXINGTON","UNITED STATES","PHYSIOLOGY","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","Project Narrative The molecular clock mechanism serves a ubiquitous cellular time-keeping function, and it regulates the tissue- specific expression of many genes. Molecular clock signaling in cardiomyocytes controls the expression of several K+ channel genes that are important for normal cardiac excitability. We are applying approaches developed in chronobiology to study the regulation of cardiac K+ channels at an entirely new level.","7001509; ","DELISLE, BRIAN P;","SHI, YANG","03/08/2019","02/28/2023","Action Potentials; Adverse event; ARNTL gene; Arrhythmia; Biological Assay; Bioluminescence; Brain; Cardiac; Cardiac Electrophysiologic Techniques; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular Physiology; cardiovascular risk factor; Cardiovascular system; Cells; Cessation of life; Chemistry; chromatin immunoprecipitation; Chronic; Chronobiology; circadian; circadian pacemaker; Circadian Rhythms; Cues; Data; Electrophoretic Mobility Shift Assay; Elements; Environment; Gene Expression; Genes; Genetic; Genetic Transcription; Goals; Half-Life; Health; Heart; heart cell; Hour; Human; Hypothalamic structure; in vivo; Incidence; insight; Ion Channel; Knowledge; Kv channel-interacting protein 2; Label; Length; Light; Long QT Syndrome; Mammals; Measures; Messenger RNA; Molecular; molecular clock; Molecular Target; mouse model; mRNA Stability; Mus; Myocardial Infarction; Patients; Pattern; Periodicity; Phase; Phenotype; Physiological; Pluripotent Stem Cells; Potassium Channel; premature; Premature Mortality; promoter; Proteins; Regulation; Reporter Genes; RNA; Role; shift work; Signal Transduction; Stroke; Sudden Death; suprachiasmatic nucleus; Telemetry; Testing; Time; Tissues; Transcript; transcription factor; Transcriptional Regulation; Transgenic Mice; Uridine; ","Transcriptional Regulation of KCNH2","141343","ESTA","Electrical Signaling, Ion Transport, and Arrhythmias Study Section ","","","02","398411","172592","571003",""
"9893601","R21","AI","1","N","03/23/2020","03/23/2020","02/28/2021","855","R21AI144658","SCHOOLS OF MEDICINE","PA-19-053","1R21AI144658-01A1","NIAID:244067\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","PORTLAND","UNITED STATES","OTHER BASIC SCIENCES","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","PROJECT NARRATIVE We recently described the Long-Chain triacylglycerol (LC-TAG) and mycolate wax ester (MWE) of Mycobacterium tuberculosis (Mtb) that are exported from the cytoplasm to the mycobacterial outer membrane or capsule by the MmpL11 transporter. TAGs and wax esters have been described as ?storage lipids?, but the fates of LCTAG and MWE once they are extracellular are not known. This proposal will test the hypothesis that Mtb utilizes exported storage lipids to promote resuscitation from hypoxic and nutrient-restricted environments.","8191270; ","PURDY, GEORGIANA E;","MENDEZ, SUSANA","03/23/2020","02/28/2022","Anabolism; Antibiotic Resistance; Bacteria; base; Biochemical; Biological; Biological Process; capsule; Carbon; Cause of Death; cell envelope; Cell Wall; Communicable Diseases; Cytoplasm; Data; deprivation; Disease; Drug Tolerance; Energy-Generating Resources; Environment; esterase; Esters; Exhibits; experimental study; extracellular; Failure; Fatty Acids; Genes; Genetic; Genus Mycobacterium; Granuloma; Homeostasis; human pathogen; Hypoxia; In Vitro; in vitro Model; in vivo; latent infection; lipid transport; Lipids; Membrane; Metabolic; Metabolism; metabolomics; Microbial Biofilms; Modeling; mutant; mycobacterial; Mycobacterium tuberculosis; mycolate; Necrosis; Nutrient; Organism; Oxygen; Pathway interactions; Phase; Phenotype; Physiology; Proteins; Recycling; Research; Research Personnel; Resource Sharing; Resources; response; Resuscitation; Role; Source; Stress; success; Surface; System; targeted treatment; Testing; transcriptome sequencing; Triglycerides; Tuberculosis; tuberculosis drugs; Up-Regulation; Virulence; Waxes; ","The role and fate of Mtb storage lipids LCTAG and MWE","144658","ZRG1","Special Emphasis Panel ","","A1","01","158485","85582","244067",""
"9898418","R01","HD","5","N","03/24/2020","03/01/2020","02/28/2021","865","R01HD097122","","PA-17-478","5R01HD097122-02","NICHD:682652\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","LOS ANGELES","UNITED STATES","","28","052277936","US","1520001","CHILDREN'S HOSPITAL OF LOS ANGELES","CA","900276062","PROJECT NARRATIVE To date, the youngest transgender/gender-nonconforming (TGNC) individuals have been overlooked despite the May 2011 Institute of Medicine (IOM) report, ?The Health of Lesbian, Gay, Bisexual, and Transgender People,? explicitly calling for NIH-supported research on the health needs of TGNC individuals, including: (1) the collection of empirical data on TGNC-specific health care to address gender dysphoria, (2) rigorous research aimed at understanding the health implications of approaches to care, and (3) longitudinal cohort studies that incorporate a life-course perspective to examine specific experiences of TGNC individuals across developmental stages. The proposed study leverages the resources of the only NIH-funded network of four US-based pediatric gender centers (Grant #R01HD082554), expanding on this current collaboration (studying TGNC adolescents) to include a younger and understudied cohort of prepubertal TGNC children. Specifically, the study aims to expand the body of empirical knowledge pertaining to gender development and cognition in TGNC children, their mental health symptomology and functioning over time, and how family-initiated social gender transition may predict or alleviate mental health symptoms and/or diagnoses.","9801731; 14648538; 11627867 (contact); 12096451; ","CHEN, DIANE ; EHRENSAFT, DIANE ; HIDALGO, MARCO  (contact); TISHELMAN, AMY C.;","ESPOSITO, LAYLA E","03/21/2019","02/29/2024","Address; Adolescence; Adolescent; Agreement; Area; Attention; base; Behavior; Behavioral; behavioral health; Birth; Boston; California; Caregivers; Caring; Characteristics; Chicago; Child; Childhood; Classification; Clinic; Clinical; clinical care; Clinical Management; clinical practice; Cognition; cohort; Collaborations; Collection; Companions; Consensus; Data; Data Reporting; Development; Diagnosis; Distress; early childhood; emerging adult; Enrollment; experience; externalizing behavior; Family; First Name; Funding; Gender; gender dysphoria; gender expression; Gender Identity; gender nonconforming; Gender Role; gender transition; Goals; Grant; Health; Healthcare; improved; Individual; Institute of Medicine (U.S.); Intervention; Investigation; Knowledge; Lesbian Gay Bisexual Transgender; Life Cycle Stages; Longitudinal cohort; Longitudinal cohort study; Longitudinal prospective study; Longitudinal Studies; Los Angeles; Measures; medical schools; Mental Health; National Institute of Child Health and Human Development; Outcome; outcome forecast; Parents; Participant; Pattern; Pediatric Hospitals; person centered; population based; prepuberty; programs; psychosocial; recruit; Reporter; Reporting; Research; Research Support; resilience; Resources; Risk; Role; Sampling; San Francisco; sex; Site; social; Subgroup; Symptoms; Time; transgender; United States; United States National Institutes of Health; Universities; University Hospitals; Work; Youth; ","A Longitudinal Study of Gender Nonconformity in Prepubescent Children","097122","PDRP","Psychosocial Development, Risk and Prevention Study Section ","","","02","585743","96909","682652",""
"9909786","F32","GM","1","N","02/19/2020","03/09/2020","03/08/2021","859","F32GM136061","SCHOOLS OF MEDICINE","PA-19-188","1F32GM136061-01","NIGMS:64554\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","CHICAGO","UNITED STATES","BIOLOGY","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","Project Narrative Coevolution of humans and our parasites shapes many facets of human health and disease. Understanding the coevolutionary process is thus a biomedical imperative, but the functional genetic experiments required to elucidate human-parasite interactions at the molecular level are often intractable. To illuminate generalizable features of coevolution, I will dissect the genetic and functional bases of interactions between cabbage white butterflies and their Arabidopsis host plants, a classic coevolutionary model.","15917937; ","O'CONNOR, TIMOTHY KEVIN;","XU, JIANHUA","03/09/2020","03/08/2023","Affect; Alleles; Amino Acid Substitution; Amino Acids; Arabidopsis; arm; Automobile Driving; base; Biochemical; Biochemistry; Biological Assay; Biological Sciences; Biology; Butterflies; Cabbage - dietary; Candidate Disease Gene; career; Chicago; comparative genomics; CRISPR/Cas technology; Disease; Event; Evolution; experimental study; Gene Duplication; Gene Proteins; Genealogy; Genes; Genetic; Genetic Phenomena; genetic variant; Genetic Variation; genome editing; genome wide association study; Genomics; Glucosinolates; Health; Human; In Vitro; in vivo; innovation; Insecta; Lead; Life; Light; Mediating; Methods; Modeling; Molecular; Mouse-ear Cress; Mustard; Mustard Plant; Mutation; Myrosinase; Natural Selections; Nature; Nitriles; novel; Parasites; Plants; Play; pleiotropism; Population; post-doctoral training; Process; protein function; Proteins; Race; reconstruction; Research; Research Personnel; Resistance; Resources; Series; Shapes; skills; Specific qualifier value; success; System; Training; Trees; Universities; Work; ","Dissecting the functional basis of butterfly-plant coevolution","136061","ZRG1","Special Emphasis Panel ","","","01","64554","","64554",""
"9910374","R25","DA","5","N","03/26/2020","03/01/2020","02/28/2021","279","R25DA033674","SCHOOLS OF MEDICINE","PAR-15-184","5R25DA033674-07","NIDA:92426\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","VERMILLION","UNITED STATES","OTHER BASIC SCIENCES","00","929930808","US","7596201","UNIVERSITY OF SOUTH DAKOTA","SD","570692307","Project Narrative The proposed training program is designed to facilitate the pipeline of young promising scientists in the field of substance abuse and mental health research. This is important given that substance abuse and related mental health issues pose a significant social, health and financial burden within the U.S., and the treatment of substance abuse and dependence is often compounded by severe mental illness. Therefore, it is critical to increase the pool of quality, innovative and highly motivated scientists in the area of substance abuse in mental health research.","8834200 (contact); 10336908; ","BURRELL, BRIAN DONALD (contact); MCFADDEN, LISA M;","COTTO, JESSICA","06/15/2013","02/29/2024","addiction; Address; Animal Behavior; Animals; Area; Arts; base; Basic Science; Behavioral; behavioral study; biobehavior; Biology; Biomedical Research; career; Clinical; Clinical Sciences; Cognitive; college; design; Discipline; Disease; Drug Addiction; Education; Electrophysiology (science); Elements; Enrollment; experience; Extramural Activities; Faculty; Family; Financial Hardship; First Generation College Students; Fostering; Health; Human; Individual; innovation; Institution; Interdisciplinary Study; Laboratories; lectures; medical schools; member; Mental disorders; Mental Health; Mentors; Methods; Molecular; multidisciplinary; National Institute of Drug Abuse; Neuropharmacology; Neurosciences; postgraduate education; programs; Psychology; Research; Research Training; Rural; rural area; Schools; Science; Scientist; severe mental illness; social; Societies; South Dakota; student training; Students; Substance abuse problem; substance abuse treatment; Substance Addiction; summer program; summer research; System; Training; Training Programs; undergraduate research; undergraduate student; Underrepresented Minority; underrepresented minority student; Underserved Population; United States; Universities; Work; ","SPURA - Summer Program for Undergraduate Research in Addiction","033674","ZDA1","Special Emphasis Panel ","","","07","85580","6846","92426",""
"9911662","F31","DA","1","N","03/11/2020","03/16/2020","03/15/2021","279","F31DA048559","SCHOOLS OF MEDICINE","PA-19-196","1F31DA048559-01A1","NIDA:38407\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","RICHMOND","UNITED STATES","PSYCHIATRY","04","105300446","US","353201","VIRGINIA COMMONWEALTH UNIVERSITY","VA","232980568","PROJECT NARRATIVE The college years represent a vulnerable period for exposure to traumatic events, as well as engagement in cannabis use, and consequently, cannabis use disorder (CUD), and posttraumatic stress disorder (PTSD). The self-medication (i.e., PTSD à CUD) and high-risk (i.e., CUD à PTSD) hypotheses have been proposed as etiologic models explaining the relationship between cannabis use and trauma-related phenotypes, but have not been thoroughly tested with longitudinal data over the course of college; furthermore, understanding whether and how genetic influences may underlie these phenotypes is also essential. This F31 award will provide the candidate with the training necessary to conduct innovative, interdisciplinary research aimed at examining the etiologic relationship between cannabis use and trauma-related phenotypes in a genetically-informative study of college students.","14380829; ","HICKS, TERRELL ALEXANDER;","BABECKI, BETH","03/16/2020","03/15/2023","Age-Years; Alcohol or Other Drugs use; Attention; Award; base; Behavioral; Biological; Cannabis; career; Clinical; clinically relevant; clinically significant; Collaborations; college; Comorbidity; Complex; Data; Development; Dropout; Drug Addiction; Drug usage; Early Intervention; Educational workshop; Environmental Risk Factor; Ethics; Etiology; Exercise; experience; Exposure to; Foundations; Frequencies; Future; Genetic; genetic analysis; Genetic Predisposition to Disease; Genetic Risk; genome wide association study; genome-wide; Genomics; Goals; Heritability; high risk; Individual; innovation; Interdisciplinary Study; International; Intervention; Knowledge; Longevity; longitudinal analysis; Longitudinal Studies; marijuana use; marijuana use disorder; Mental Health; Mentorship; Mission; Modeling; Molecular; Molecular Analysis; Molecular Genetics; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; National Research Service Awards; Outcome; Pattern; Phenotype; phenotypic data; physical conditioning; Population; Post-Traumatic Stress Disorders; Predisposition; Prevalence; Preventive Intervention; prospective; Recording of previous events; Research; Research Training; Risk; Risk Factors; Sampling; Science; Self Medication; skill acquisition; social; Solid; Statistical Methods; statistics; Strategic Planning; Substance Use Disorder; suicidal risk; Techniques; Testing; Time; Training; trait; Trauma; trauma exposure; traumatic event; Twin Multiple Birth; Universities; university student; young adult; ","Genetics of Cannabis use and Trauma-related phenotypes","048559","ZRG1","Special Emphasis Panel ","","A1","01","38407","","38407",""
"9930694","K43","TW","5","N","03/23/2020","03/01/2020","02/28/2021","989","K43TW011178","","PAR-17-001","5K43TW011178-03","FIC:113400\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","CAPE TOWN","SOUTH AFRICA","","","538552788","SF","10028111","UNIVERSITY OF CAPE TOWN LUNG INSTITUTE","","7700","Project Narrative Immune-mediated adverse drug reactions (IM-ADRs) are a major obstacle to treatment success in both TB and HIV and a cause of tremendous morbidity, management complexity and economic burden. IM-ADRs are 100-fold more common in persons with HIV/AIDs, and over-represented in Africa; however, the immune pathogenesis is poorly understood, especially in non-European and HIV-infected populations. This study will fill significant gaps in our understanding of IM-ADR, for drugs used to treat HIV and TB in African populations. !","14280621; ","PETER, JONATHAN ;","BANSAL, GEETHA PARTHASARATHY","09/16/2018","02/28/2023","abacavir; Acquired Immunodeficiency Syndrome; Acute; Address; adverse drug reaction; Adverse reactions; Affect; Africa; Africa South of the Sahara; African; AIDS/HIV problem; Alleles; Antigens; antiretroviral therapy; Antitubercular Agents; Area; Biological Assay; Biology; Biopsy Specimen; burden of illness; Carbamazepine; CD3 Antigens; CD4 Positive T Lymphocytes; CD8-Positive T-Lymphocytes; CD8B1 gene; Cells; Cessation of life; Clinical; clinical phenotype; Clinical Research; Cluster Analysis; co-infection; cohort; Comorbidity; Complex; Cutaneous; Data; Development; Disease; Drug Controls; Drug Exposure; Drug Hypersensitivity; Drug Kinetics; drug metabolism; Drug Targeting; Drug usage; Early Diagnosis; Early treatment; Economic Burden; Epidemiology; epidemiology study; Etiology; Flow Cytometry; follow-up; Genetic; Genetic Polymorphism; genetic risk factor; Genomics; Goals; Health Care Costs; High Prevalence; Histocompatibility Antigens Class I; Histopathology; HIV; HIV Infections; HIV/TB; Hospitalization; Human; Hypersensitivity; Immune; immune activation; immune reconstitution; immunoglobulin receptor; Immunohistochemistry; Immunologics; Immunology; in vivo; Individual; innovation; Laboratories; Lead; Link; Mediating; Mentorship; Molecular; Molecular Immunology; Morbidity - disease rate; mortality; novel; Pathogenesis; Patients; peripheral blood; Persons; Pharmaceutical Preparations; Pharmacogenomics; Pharmacology; Pharmacotherapy; Phase; Phenotype; Population; predictive marker; Prevention; programs; Reaction; Recovery; Research; Resolution; Resources; response; Risk; Risk Factors; risk variant; Science; screening; Signal Transduction; Site; skills; Skin; Source; South Africa; Stevens-Johnson Syndrome; success; T cell response; T-Cell Receptor; T-Lymphocyte; targeted treatment; Technical Expertise; Techniques; Testing; Therapeutic; Time; Tissues; tool; Toxic Epidermal Necrolysis; Training; transcriptome sequencing; Translating; Translations; treatment optimization; Tuberculosis; tuberculosis treatment; whole genome; ","IMmune-mediated Adverse drug Reactions In African HIV endemic setting (IMARI-SA study)","011178","ICP1","International and Cooperative Projects - 1 Study Section ","","","03","105000","8400","113400",""
"9933393","P40","OD","2","N","03/23/2020","02/10/2020","01/31/2021","","P40OD010938","","PAR-17-006","2P40OD010938-40","OD:655734\","RESEARCH CENTERS","2020","OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH","","HOUSTON","UNITED STATES","","09","800772139","US","578407","UNIVERSITY OF TX MD ANDERSON CAN CTR","TX","770304009","","2079066; ","WILLIAMS, LAWRENCE E;","","","","Age; Animals; Area; Biocompatible Materials; Biological; Biomedical Research; Blood; Bolivian; brain tissue; Breeding; Caregivers; Caring; Communities; Conceptions; Data Analyses; Data Management Resources; Databases; DNA; Doctor of Philosophy; Female; fetal; Foundations; Genetic; genetic analysis; genetic pedigree; Genome; Genomics; Goals; improved; Inbreeding; Individual; Intramural Research Program; Laboratories; Lead; Liquid substance; Medical History; Medical Records; Modeling; Monitor; novel strategies; Peruvian; Pharmacologic Substance; Play; Population Genetics; Privatization; reproductive; Research; Research Contracts; Research Personnel; Resources; Role; Saimiri; Scientist; Services; social group; Source; symposium; Technology; Tissues; tool; Training and Education; United States National Institutes of Health; Veterinarians; Work; ","Squirrel Monkey Breeding and Research Resource: Resource Core","010938","ZRG1","Special Emphasis Panel ","5280","","40","409834","245900","","655734"
"9938589","R01","EB","5","N","03/25/2020","03/01/2020","02/28/2021","286","R01EB027653","","PA-18-484","5R01EB027653-02","NIBIB:457978\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Project Narrative This proposal is relevant to public health because the development of better tools to measure the hardness and softness of biomaterial, tissue and cell will advance our understanding how the mechanical properties affect health and disease and how they can be used to improve diagnosis and treatment, for example, in stem cell therapy and eye surgery. Therefore, the proposed research is relevant to the NIH?s mission of fostering innovative research strategies to increase the nation?s ability to improve the treatment of disease.","7879022; ","YUN, SEOK-HYUN ANDY;","KING, RANDY LEE","06/01/2019","02/28/2023","3-Dimensional; Adoption; Affect; Area; Atomic Force Microscopy; base; Biocompatible Materials; Biological; Biological Process; Biomechanics; Cells; Cellular Morphology; Cues; Cytoskeleton; data acquisition; Detection; Development; Devices; Diagnosis; Disease; disease diagnosis; elastography; Elements; Environment; experience; extracellular; Extracellular Matrix; Extracellular Space; Fostering; Frequencies; Goals; haptics; Hardness; Health; Hydrogels; Image; improved; In Situ; innovation; Interferometry; Intracellular Space; Label; Lasers; Light; Measurement; Measures; mechanical load; mechanical properties; Mechanics; Medical; Microscope; Microscopic; Microscopy; millimeter; millisecond; Mission; Modality; Modeling; Modulus; molecular scale; Movement; Nature; novel; Ophthalmologic Surgical Procedures; Optics; Organism; Organoids; Phenotype; physical science; Physiologic pulse; Play; Process; Property; Public Health; Research; Resolution; Role; Sampling; scaffold; Scheme; Science; Slice; Source; Spectrum Analysis; Speed; stem cell therapy; Stem cells; Stress; Surface; System; Techniques; Technology; Time; tissue regeneration; Tissues; tool; Ultrasonography; United States National Institutes of Health; Work; Wound Healing; ","Development of stimulated Brillouin microscopy for high-resolution stiffness measurement","027653","ISD","Instrumentation and Systems Development Study Section ","","","02","272606","185372","457978",""
"9939712","U54","MD","5","N","03/18/2020","02/01/2020","01/31/2021","","U54MD007597","","RFA-MD-17-006","5U54MD007597-32","NIMHD:193776\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","WASHINGTON","UNITED STATES","","98","056282296","US","3499801","HOWARD UNIVERSITY","DC","200590005","","6522277; ","HADDAD, GEORGES E.;","","","","Address; Affect; African American; Applications Grants; Area; Award; Behavioral; Behavioral Research; Biomedical Research; Biophysics; career; career development; Clinical Research; college; Communities; Data; Development; Discipline; Disease; Educational workshop; Elements; Extramural Activities; Faculty; Funding; Future; Goals; Grant; Growth; health disparity; Medicine; Mentors; Mentorship; Methods; minority health; model development; Monitor; Names; new technology; Physiology; Pilot Projects; Play; Positioning Attribute; Process; professor; Program Development; programs; Research; Research Personnel; response; Role; Seasons; Secure; Seeds; skills; Training; Universities; Writing; ","Investigator Development Core (IDC)","007597","ZMD1","Special Emphasis Panel ","5947","","32","152066","84107","","193776"
"9986023","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007590","","RFA-MD-18-012","5U54MD007590-33","NIMHD:469676\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","ATLANTA","UNITED STATES","","05","065325177","US","2189101","CLARK ATLANTA UNIVERSITY","GA","303144358","Research Infrastructure Core Project Narrative This core will provide access to instrumentation, training as well as animal services to the research and pilot projects.","8630420; ","ODERO-MARAH, VALERIE ;","","","","Address; African American; African Caribbean; American; animal care; Animal Experimentation; animal facility; Animals; anticancer research; Bioinformatics; Biological Factors; Biometry; Cancer Etiology; Caucasians; Cellular biology; Cessation of life; Collaborations; Communities; Core Facility; Death Rate; Development; Ensure; Environmental Risk Factor; Equipment; Funding; Genetic; Genomics; Histology; Image; Imaging Device; Incidence; indexing; instrument; instrumentation; Laboratories; laboratory facility; Laboratory Personnel; Logistics; Malignant neoplasm of lung; Malignant neoplasm of prostate; Malignant Neoplasms; member; men; Methodology; Minority-Serving Institution; Molecular Biology; Morehouse School of Medicine; mortality; NCI Center for Cancer Research; operation; Parents; Patients; Phase; Pilot Projects; Postdoctoral Fellow; programs; prostate cancer metastasis; Proteomics; racial disparity; repository; Research; research and development; research facility; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; senior faculty; Services; Signal Transduction; structural biology; success; Supervision; therapeutic development; tissue resource; Tissues; Training; training project; Translational Research; Travel; Universities; ","Research Infrastructure Core","007590","ZMD1","Special Emphasis Panel ","8339","","33","332049","137790","","469676"
"9986024","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007590","","RFA-MD-18-012","5U54MD007590-33","NIMHD:218716\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","ATLANTA","UNITED STATES","","05","065325177","US","2189101","CLARK ATLANTA UNIVERSITY","GA","303144358","Project Narrative ? Investigator Development Core The Investigator Development Core (IDC) will support the development for competitive and diverse pilot research projects in basic biomedical and behavior sciences from early stage investigators and postdoctoral fellows and provide mentoring for pilot project recipients.","7027023; ","WANG, ZHENGXIN ;","","","","Achievement; Address; anticancer research; Area; base; Basic Science; Behavior; Behavioral; Behavioral Sciences; behavioral/social science; Benchmarking; Biological; biological research; Cancer Biology; cancer health disparity; Communities; Data; Development; Discipline; Education and Outreach; effective intervention; Extramural Activities; Faculty; faculty research; Funding; Goals; Grant; health disparity; improved; interdisciplinary collaboration; Malignant neoplasm of prostate; Measures; Medical Research; member; Mentors; Methods; Monitor; NCI Center for Cancer Research; Performance; Pilot Projects; Postdoctoral Fellow; Process; programs; prospective; Psychology; recruit; Research; research and development; Research Personnel; Research Project Grants; Research Proposals; Science; Scientist; social; social science research; Social Sciences; Source; success; tenure track; Testing; theories; therapeutic development; United States National Institutes of Health; Universities; ","Investigator Development Core","007590","ZMD1","Special Emphasis Panel ","8340","","33","142069","76717","","218716"
"9987740","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007582","","RFA-MD-18-012","5U54MD007582-35","NIMHD:414665\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","TALLAHASSEE","UNITED STATES","","05","623751831","US","513802","FLORIDA AGRICULTURAL AND MECHANICAL UNIV","FL","323073105","","9481306; ","LEE, EUN SOOK YU;","","","","Address; African American; Applications Grants; Award; Behavioral; career; Communities; Core Facility; cost; Data; Development; disability; Disadvantaged; Economics; Educational workshop; Ensure; Ethnic group; ethnic minority population; Evaluation; experience; Extramural Activities; Faculty; Florida; Fostering; Funding; Funding Mechanisms; Generations; Goals; Grant; Health; health disparity; Health Services Accessibility; Health Status; Hispanics; improved; indexing; Individual; Infrastructure; innovation; interest; Journals; K-Series Research Career Programs; Knowledge; Mainstreaming; medically underserved; Mentors; Methodology; Minority; Minority Groups; minority health; minority investigator; minority scientist; Molecular; Native Americans; novel; Oral; Paper; Pilot Projects; Population; Postdoctoral Fellow; Procedures; Program Development; programs; Publishing; Quality of Care; Race; racial and ethnic; racial minority; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Scientist; Secure; Series; skills; socioeconomics; success; Training; United States National Institutes of Health; Universities; Work; Writing; ","Investigator Development Core","007582","ZMD1","Special Emphasis Panel ","8127","","35","280179","134486","","414665"
"10050160","P30","CA","3","N","03/24/2020","12/01/2019","11/30/2020","397","P30CA016086","SCHOOLS OF MEDICINE","PAR-13-386","3P30CA016086-44S1","NCI:250000\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","CHAPEL HILL","UNITED STATES","INTERNAL MEDICINE/MEDICINE","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","NARRATIVE The Lineberger Comprehensive Cancer Center (LCCC) forms the nexus for researchers focused on understanding and identifying the mechanisms leading to, the prevention of, and treatments for cancer. LCCC is an integral component of the research mission at The University of North Carolina (UNC) at Chapel Hill, coalescing the cancer research capabilities of the Schools of Medicine, Public Health, Pharmacy, and Nursing, and the College of Arts and Sciences. The LCCC strives to reduce cancer incidence, morbidity, and mortality in North Carolina, the United States and across the globe through innovative research, cutting-edge treatments, multi-disciplinary training, education and outreach.  ","6477317; ","EARP, HENRY SHELTON;","SHAFIK, HASNAA","06/01/1997","11/30/2020","Address; African American; angiogenesis; anticancer research; Apoptosis; Area; Arts; Basic Cancer Research; Basic Science; Behavior Therapy; Big Data; Biochemistry; Biological; Biology; Blood Vessels; Breast; Cancer Biology; cancer care; cancer cell; Cancer Center; Cancer Center Support Grant; cancer health disparity; Cancer Intervention; cancer therapy; Caregivers; Case-Control Studies; Catchment Area; Cell Cycle; Cell Cycle Regulation; cell motility; Cells; Cellular biology; Cessation of life; Chromatin; Clinical; clinical care; Clinical Research; Clinical Sciences; Clinical Trials; Cohort Studies; college; Colon; combat; Comprehensive Cancer Center; Core Facility; cost; Data; Dentistry; Development; Devices; Diagnostic; Discipline of Nursing; DNA biosynthesis; DNA Repair; Early Diagnosis; Education and Outreach; effective therapy; Ensure; Epidemiology; Epigenetic Process; Etiology; Extramural Activities; Faculty; Fostering; Foundations; Funding; Future; Gap Junctions; Generations; Goals; Grant; Growth Factor Receptors; Health Services; Healthcare Systems; Home environment; Hospitals; Incidence; innovation; insight; Intervention; Investigation; Leadership; Malignant Neoplasms; medical schools; member; Metabolism; Minority; Mission; Modernization; Molecular; Morbidity - disease rate; mortality; multidisciplinary; Neoplasm Metastasis; new therapeutic target; North Carolina; novel; oncology; Outcome; outreach; Pathogenesis; Pharmacy facility; Population; Population Sciences; Population Study; Pre-Clinical Model; Prevention; programs; Prostate; Public Health; Publishing; Research; research and development; Research Design; Research Personnel; Resistance; Risk Factors; RNA; Role; Science; Scientist; Signal Transduction; student training; Students; survivorship; targeted cancer therapy; Therapeutic; Therapeutic Intervention; Training; Training and Education; Transcriptional Regulation; Translational Research; tumor initiation; tumor registry; underserved minority; Underserved Population; United States; Universities; Ursidae Family; Work; ","Cancer Center Support Grant","016086","NCI","Subcommittee H - Clinical Groups ","","S1","44","175619","74381","250000",""
"10083805","K23","EY","7","N","03/23/2020","03/01/2020","06/30/2020","867","K23EY025273","SCHOOLS OF OPTOMETRY/OPHT TECH","PA-18-590","7K23EY025273-06","NEI:150000\","OTHER RESEARCH-RELATED","2019","NATIONAL EYE INSTITUTE","","BIRMINGHAM","UNITED STATES","OTHER HEALTH PROFESSIONS","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","PUBLIC HEALTH RELEVANCE: Myopia is a common eye disease and is listed among the top five priority eye diseases by the World Health Organization due to its high prevalence and significant socio-economic effects worldwide. The reported prevalence of myopia has increased significantly over the past three or four decades, and it currently affects approximately one-third of the population in the United States. The results of the proposed study can potentially change the standard of care for the treatment of myopia in children, and lead to novel strategies that optimize the effect of myopia control through combined pharmacological and optical interventions.","12051394; ","HUANG, JUAN ;","AGARWAL, NEERAJ","03/01/2020","06/30/2020","","Myopia Control in Children with Low-Dose Atropine and Soft Bifocal Contact Lenses","025273","ZEY1","Special Emphasis Panel ","","","06","138889","11111","150000",""
"10113901","R44","NS","7","N","03/25/2020","03/15/2020","06/30/2020","853","R44NS097113","","PA-17-302","7R44NS097113-05","NINDS:531286\","SBIR-STTR RPGs","2019","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","ATLANTA","UNITED STATES","","05","116978015","US","10053924","BIOCIRCUIT TECHNOLOGIES, INC.","GA","303091855","Project Narrative We are developing a microhook-based nerve tape device for wrapping around and holding together the two ends of a cut nerve. The distributed array of microscopic hooks strongly affixes to the outside of the nerve without penetrating into the delicate interior. Microhook nerve tape?s simple design and ease-of-use enables rapid implantation and consistently high repair quality to enhance functional recovery from potentially debilitating nerve injuries.","12197523; ","CLEMENTS, ISAAC PERRY;","CAPORELLO, EMILY LAURA","01/01/2020","06/30/2020","","Microhook nerve tape: A nerve repair coaptation aid","097113","ZRG1","Special Emphasis Panel ","","","05","","","531286",""
"10118001","R21","CA","7","N","03/27/2020","01/01/2020","08/31/2020","396","R21CA231111","","PA-18-590","7R21CA231111-02","NCI:182700\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","ELK GROVE","UNITED STATES","","07","808833771","US","10024544","CALIFORNIA NORTHSTATE UNIVERSITY","CA","957578145","PROJECT NARRATIVE A germline mutation is a change in the body's reproductive cells? (egg or sperm) DNA that becomes part of every cell in the body of the offspring. Genes in which germline mutations confer increased risks of cancer are called cancer predisposition genes (CPGs). We will develop a computational method to study CPG germline mutations in relation to other genetic changes in breast cancer, so we can identify new ways to intercept the disease and devise new strategies for treatment and prevention.","9507302; ","SHI, YIHUI ;","LI, JERRY","09/11/2019","08/31/2021","","Identification of Synthetic Lethal Partners of Cancer Germline Mutations using PanCancer Human Primary Tumor Data","231111","ZCA1","Special Emphasis Panel ","","","02","130500","52200","182700",""
"10118922","R35","GM","3","N","03/27/2020","02/01/2020","04/30/2020","859","R35GM118093","GRADUATE SCHOOLS","RFA-GM-16-002","3R35GM118093-04S2","NIGMS:25757\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","NEW YORK","UNITED STATES","BIOLOGY","13","049179401","US","1833202","COLUMBIA UNIV NEW YORK MORNINGSIDE","NY","100277922","PUBLIC HEALTH RELEVANCE    Defects in pre-mRNA processing are linked to human diseases. Our studies will contribute to understanding the molecular mechanism for mRNA processing, stability and degradation.","2197274; ","TONG, LIANG ;","BENDER, MICHAEL T","02/01/2020","04/30/2021","Biochemical; Cell Nucleus; Cells; Cleavage And Polyadenylation Specificity Factor; cleavage factor; Cleavage Stimulation Factor; Complex; Cytoplasm; Defect; Event; experimental study; Fibrinogen; Genetic Transcription; Histones; human disease; Knowledge; Link; Mammals; Messenger RNA; Molecular; Molecular Mechanisms of Action; mRNA capping; mRNA Precursor; Polyadenylation; Polynucleotide Adenylyltransferase; Protein Family; Proteins; Prothrombin; public health relevance; Quality Control; RNA; RNA Polymerase II; RNA Splicing; stem; Structure; Yeasts; ","Structural and functional studies of mRNA processing, stability and quality control","118093","ZGM1","Special Emphasis Panel ","","S2","04","17310","8447","25757",""
"10123991","UM1","AI","3","N","03/25/2020","03/25/2020","11/30/2020","855","UM1AI148452","","PA-18-591","3UM1AI148452-01S1","NIAID:192338\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","PROJECT NARRATIVE The goal of the Vanderbilt VTEU is to leverage the robust clinical research environments at four major US institutions to conduct high quality clinical research across the age spectrum and covering multiple infectious diseases. We will focus on our areas of strength, which includes early phase clinical trials of new vaccines and therapeutics; innovative laboratory assays; rapid enrollment, including enrollment of special populations; subject matter expertise across infectious diseases, including bacterial, viral, respiratory, parasitic, and sexually transmitted infections; and training of young vaccinologists and clinical trialists.","8638027; ","CREECH, CLARENCE BUDDY;","TAUSCHER, GAIL H","12/11/2019","11/30/2026","Academic Medical Centers; Adult; Age; Antibiotic Resistance; Area; Award; Bacterial Infections; base; Biological; Biological Assay; career; career development; Child; Childhood; Clinical; Clinical Investigator; Clinical Research; clinical research site; Clinical Trials; Communicable Diseases; Comorbidity; Conduct Clinical Trials; Data; design; Development; Disease; Education; Elderly; Emerging Communicable Diseases; Enrollment; Environment; ethnic diversity; Evaluation; experience; Faculty; Feasibility Studies; Fellowship; Fostering; Funding; Geography; Goals; Home environment; Human; Immune response; Immunity; Immunization; immunogenicity; Immunologist; Individual; Infant; Infection; Influenza; influenza virus vaccine; innovation; Institution; International; Intervention; Laboratories; Laboratory Scientists; Lead; Leadership; Licensure; Longevity; Malaria; Malaria Vaccines; Medical; Medical center; Mentors; Mentorship; Methods; Modeling; Mycoses; named group; next generation; novel; novel strategies; novel therapeutics; novel vaccines; Nurses; pandemic influenza; Parasitic infection; pathogen; Pathogenesis; Pennsylvania; Pertussis Vaccine; Peru; Pharmaceutical Preparations; Phase; Physicians; Pneumococcal vaccine; Population; Population Heterogeneity; Positioning Attribute; Pregnant Women; Prevention; Principal Investigator; Procedures; Process; Protocols documentation; recruit; Research; Research Infrastructure; Research Personnel; research study; respiratory; response; Safety; Scientist; Sexually Transmitted Diseases; Site; Smallpox Vaccine; Standardization; Systems Biology; Tissues; tool; Training; United States National Institutes of Health; Universities; Vaccination; Vaccine Research; vaccine trial; Vaccines; vaccinology; Viral; Virus Diseases; Visit; volunteer; Washington; Work; ","Vanderbilt Vaccine and Treatment Evaluation Unit","148452","","","","S1","01","113140","79198","192338",""
"10130930","R01","AI","3","N","03/26/2020","07/01/2019","06/30/2020","855","R01AI118505","SCHOOLS OF MEDICINE","PA-13-302","3R01AI118505-05S1","NIAID:92512\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BALTIMORE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","PUBLIC HEALTH RELEVANCE: This is a proposal to develop and conduct a non-randomized effectiveness and cost- effectiveness study of a multi-level combination HIV preventive intervention with and without daily oral Truvada pre-exposure prophylaxis (PrEP) with mobile phone-based adherence support among young men who have sex with men (YMSM, aged 18-26) in Bangkok, Thailand. The study will include a formative phase, with the refinement of a multi-level combination intervention; an effectiveness trial with an HIV incidence endpoint; and a costing and cost- effectiveness component among 1240 YMSM in a high HIV incidence context.","6519242; ","BEYRER, CHRISTOPHER ;","SHARMA, USHA K","07/01/2015","06/30/2020","Acute; acute infection; Address; Adherence; aged; AIDS prevention; Asia; Awareness; base; behavior change; Car Phone; Caring; Centers for Disease Control and Prevention (U.S.); Cohort Studies; Collaborations; Communities; community clinic; community consultation; condoms; cost; Cost Analysis; cost effective; cost effectiveness; Cost Measures; Cost Savings; Counseling; Data; density; design; disability-adjusted life years; Effectiveness; effectiveness trial; empowerment; emtricitabine; Enrollment; Epidemic; experience; Foundations; Goals; Health Promotion; high risk; HIV; HIV Infections; HIV Seropositivity; Human immunodeficiency virus test; Incidence; Individual; Infection; Intervention; LGBT Health; Lubricants; male; male sex worker; member; men; men who have sex with men; Methods; open label; Oral; Participant; Persons; Phase; Population; pre-exposure prophylaxis; Prevention; Prevention strategy; Preventive Intervention; Procedures; Process; Prostitution; public health relevance; Qualitative Methods; Recording of previous events; Reporting; Research; Research Design; Rights; Risk; Risk Reduction; Scoring Method; Service provision; Services; sex; sexual risk taking; Structural Models; Tenofovir; Testing; Thailand; Time; Treatment Cost; truvada; Universities; uptake; Work; young man; young men who have sex with men; ","Effectiveness of combination HIV preventive interventions for young Thai MSM","118505","BSPH","Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section ","","S1","05","70199","22313","92512",""
"9703472","P01","AG","2","N","03/25/2020","04/01/2019","03/31/2020","","P01AG014449","","PAR-18-297","2P01AG014449-22","NIA:832053\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","PHOENIX","UNITED STATES","","07","131606022","US","2052813","ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER","AZ","850134409","","2183135; ","MUFSON, ELLIOTT JAY;","","","","AD pathology; Affect; Alternative Splicing; Alzheimer's Disease; Amyloid; Animals; Anterior; Anterolateral; Antibodies; Apolipoprotein E; Autopsy; basal forebrain; basal forebrain cholinergic neurons; Basal Nucleus of Meynert; base; Basic Science; Cells; cholinergic; Cholinesterase Inhibitors; cingulate cortex; Clinical; Cognition; Cognitive; Cohort Studies; Complex; connectome; Data; Defect; Dementia; density; Development; Disease; disease diagnosis; Disease Progression; Dorsal; Drug Design; Drug Targeting; early detection biomarkers; Elderly; Episodic memory; Event; Evolution; Executive Dysfunction; executive function; Exons; familial Alzheimer disease; frontal lobe; Functional disorder; Gene Expression Regulation; Genes; Genetic Transcription; Goals; Heterogeneous-Nuclear Ribonucleoproteins; Hippocampus (Brain); Human; immunocytochemistry; Impaired cognition; improved; In Vitro; in vivo; Individual; innovation; Intervention; invention; Laboratories; Libraries; Link; Medial; Memory; Messenger RNA; Metabolic; Metabolism; mild cognitive impairment; Molecular; morphometry; Neocortex; Nerve Degeneration; nervous system disorder; Neurobiology; neurofibrillary tangle formation; Neurofibrillary Tangles; neuroimaging; Neurons; neurotransmission; novel; novel marker; Nuclear; Onset of illness; Optics; Participant; Pathogenicity; Pathology; Pattern; Pharmaceutical Preparations; Phosphotransferases; Plant Roots; Play; Population; Post-Translational Protein Processing; pre-clinical; protein expression; Protein Isoforms; Proteins; Religion and Spirituality; Reporting; Ribosomal RNA; Risk; RNA; RNA Splicing; Role; Series; Sirtuins; Site; spatiotemporal; Spliceosomes; SRSF2 gene; Study Subject; Subgroup; Symptoms; System; tau expression; tau phosphorylation; tau Proteins; Technology; Temporal Lobe; Testing; Tissue Sample; Tissues; transcriptome sequencing; Translating; U1 Small Nuclear Ribonucleoprotein; Untranslated RNA; ","Project 3 (BNI)-Cholinergic alteration in mild cognitive impairment","014449","ZAG1","Special Emphasis Panel ","7797","","22","710698","121355","","832053"
"9851954","K08","NS","5","N","03/25/2020","02/01/2020","01/31/2021","853","K08NS097704","SCHOOLS OF MEDICINE","PA-16-191","5K08NS097704-04","NINDS:199800\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","BALTIMORE","UNITED STATES","PEDIATRICS","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","PROJECT NARRATIVE Perinatal hypoxic-ischemic brain injury has devastating consequences, impairing quality of life for patients and their families and carrying with it substantial costs to society. The proposed studies investigating the mechanisms by which neural stem and progenitor cells respond to such injury will provide a better understanding of the role of neurogenesis in the acute recovery phase and hopefully lead to novel therapeutic targets for improving outcomes.","6706159; ","FELLING, RYAN J;","KOENIG, JAMES I","02/01/2017","01/31/2022","Acute; adult neurogenesis; Base Excision Repairs; BDNF gene; Behavior; Biological Markers; Biology; Brain; Brain Hypoxia-Ischemia; Brain Injuries; Brain region; brain repair; Brain-Derived Neurotrophic Factor; career; career development; Cell Differentiation process; Cell physiology; cell type; Cells; Cerebral Palsy; Childhood; clinical application; cost; Cytosine; Data; demethylation; design; Development Plans; Disease; DNA; DNA Methylation; DNA Sequence; Ensure; Environment; Epigenetic Process; epigenetic regulation; Epilepsy; experimental study; Family; Funding; GADD45A gene; Gene Expression Regulation; gene induction; Gene Silencing; Genes; Genetic; Genetic Transcription; Growth Factor; Heritability; Heterogeneity; Human; Hypoxia; Hypoxic-Ischemic Brain Injury; Impairment; improved; improved outcome; in vivo; Inflammatory; Injury; innovation; Intellectual functioning disability; interest; Ischemia; Knock-out; Knowledge; Lead; Life; Link; Mediating; methylation pattern; methylomics; migration; Mixed Function Oxygenases; Modification; Molecular; Morbidity - disease rate; Natural regeneration; nerve stem cell; neurogenesis; Neurologic; Neurosciences; new therapeutic target; notch protein; novel; Organism; overexpression; Paint; Pathway interactions; Patients; Perinatal; Perinatal Brain Injury; Perinatal Hypoxia; Phase; Phenotype; Play; Population; postnatal; Process; progenitor; Protein Family; Quality of life; Recovery; Regulation; repaired; Research; response; Rodent; Role; single-cell RNA sequencing; Societies; sound; stem cell biology; Stem cells; Stimulus; stroke recovery; subventricular zone; Techniques; Tetanus Helper Peptide; Therapeutic; therapy design; Training; transcriptome; Transgenic Organisms; Translating; Translational Research; ","Epigenetic regulation of neurogenesis following perinatal hypoxic-ischemic brain injury","097704","NST","NST-2 Subcommittee ","","","04","185000","14800","199800",""
"9853533","P20","GM","1","N","03/24/2020","12/01/2019","11/30/2020","","P20GM130418","","PAR-18-266","1P20GM130418-01A1","NIGMS:234224\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MISSOULA","UNITED STATES","","00","010379790","US","1381006","UNIVERSITY OF MONTANA","MT","598124104","","10117412; ","SEMMENS, ERIN O'BRIEN;","","","","Accounting; Achievement; Acute; Address; Admission activity; Age-Months; Air Pollutants; Air Pollution; American; Area; autism spectrum disorder; Birth; Birth Certificates; Birth Weight; Cardiovascular system; Child; Child Health; Childhood; Chronic; climate change; Clinic; Collaborations; Communication; Communities; Computerized Medical Record; Cookstove; Country; Data; Data Sources; Death Certificates; Development; early childhood; Education; Electronic Health Record; Ensure; Environmental Exposure; Environmental Impact; epidemiology study; Event; experience; Exposure to; Federally Qualified Health Center; Fetal Death; Fetal Mortality Statistics; Fire - disasters; forest; Frequencies; Future; Gestational Age; Health; health care service organization; Health system; Healthcare Systems; Heating; Hospitals; Household; Human; Impairment; improved; Income; Individual; Industry; Infant; Infant Development; Infant Mortality; interest; Intervention; Investigation; Knowledge; Link; Literature; Low Birth Weight Infant; Measures; Medical center; Modeling; Modification; Montana; mortality; Mothers; Neighborhoods; Neonatal Intensive Care Units; neurodevelopment; novel; Outcome; Participant; Particulate; Particulate Matter; Population; predictive modeling; Pregnancy; premature; Premature Birth; Prevention Research; Public Health; Records; Research; residence; resilience; Resource Development; Resources; respiratory health; Risk; Rural; rural area; Rural Community; Science; Seasons; Services; Severities; Small for Gestational Age Infant; social capital; Socioeconomic Status; Source; spatiotemporal; Spontaneous abortion; Surveys; Testing; therapy design; Time; trend; Wildfire; Wood stove; Work; ","Project 1: Wildfire impacts on birth and developmental outcomes in a rural state","130418","ZGM1","Special Emphasis Panel ","7781","A1","01","163685","70539","","234224"
"9853778","R01","DK","5","N","03/27/2020","02/01/2020","01/31/2021","847","R01DK116294","SCHOOLS OF MEDICINE","PA-16-160","5R01DK116294-08","NIDDK:419840\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NEW YORK","UNITED STATES","PSYCHIATRY","12","121911077","US","5998304","NEW YORK UNIVERSITY SCHOOL OF MEDICINE","NY","10016","Narrative and Relevance The obesity pandemic is no longer considered as just a major health problem, but also as an economic predicament that places an enormous financial burden on family and society for the care and treatment of patients. The obese patients often suffer from its associated illnesses such as diabetes, hypertension, dyslipidemia and cardiovascular diseases. The healthcare costs attributed to the obesity related illnesses have significantly increased in the past decades and will continue to rise in the next 20 years.  The continued rise of this epidemic is largely due to the availability of highly dense, caloric food, and poor eating habit. The central circuit regulating food intake such as the melanocortin system in the mammalian hypothalamus has been identified and studied, but we still do not have clear understanding of how these orexigenic and anorexigenic neurons in the melanocortin system are regulated by hunger or satiety, whether these neurons respond to any or specific macronutrients, whether the intimately interwoven orexigenic and anorexigenic neurons exists in invertebrate, and how these neurons regulating feeding behavior interact with other circuits mediating related behaviors.  In this renewal application, we will investigate the functions of the recently identified orexigenic and anorexigenic neurons in the Drosophila brain and determine the mechanisms by which feeding is regulated by these neurons using genetic, molecular, physiology tools, and behavior assays readily available in Drosophila. It is also easier to conduct a large number of trials in behavior testing and other experiments using flies to accelerate our understanding of feeding behavior. These would not only provide a valuable conceptual framework, but could also lead to development of therapeutic application to treat obesity and eating disorders.","8566669; ","RYOO, HYUNG D;","KARP, ROBERT W","09/13/2012","01/31/2022","Adult; Anatomy; Animals; Appetite Stimulants; base; Behavior; behavior test; Behavioral Assay; Biological Assay; Brain; Calcium; Cardiovascular Diseases; Caring; Coupled; deprivation; Diabetes Mellitus; Diet Habits; Drosophila genus; Dyslipidemias; Eating; Eating Disorders; Economics; Electrophysiology (science); Epidemic; Exhibits; experimental study; Exposure to; Family; feeding; Feeding behaviors; Financial Hardship; fly; Food; Food deprivation (experimental); Genes; Genetic; Genetic Transcription; Glucose; Health; Health Care Costs; Hemolymph; Hunger; Hypertension; Hypothalamic structure; Image; In Vitro; in vivo; Invertebrates; L-Glucose; Label; Laboratories; Lead; Macronutrients Nutrition; Maps; Mediating; Membrane Potentials; Metabolic; Methods; Molecular; Molecular Genetics; Monitor; mutant; Neurons; Neurotransmitters; Nutrient; Nutritional; Obesity; overexpression; Palate; pandemic disease; Patients; Peripheral; Physiology; Play; Population; Potassium; preference; Process; Publishing; receptor function; Regulatory Element; response; Role; Satiation; sensor; Serotonin; Sleep; Societies; Sodium; solute; Starvation; sugar; sweet receptor; symporter; System; Taste Buds; Taste Perception; Techniques; Testing; therapeutic development; tool; Transcript; ","Characterization of Taste-independent Sugar Sensor in the Brain","116294","SCS","Somatosensory and Chemosensory Systems Study Section ","","","08","247692","172148","419840",""
"9854055","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:269633\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","2091623; ","HICKE, LINDA A.;","","","","anticancer research; Area; Baltimore; base; Basic Science; Biology; Cancer Biology; Cancer Center; cancer education; cancer genetics; cancer genomics; cancer therapy; career; career development; CLIA certified; Clinical; clinical decision-making; Clinical Informatics; cohesion; Communication; Communities; Community Clinical Oncology Program; Complex; Comprehensive Cancer Center; Continuing Education; continuing medical education; Core Grant; curriculum development; Decision Making; design; E-learning; Education; Education and Outreach; educational atmosphere; Educational Curriculum; Educational process of instructing; Educational workshop; Event; experience; Faculty; faculty mentor; Fostering; Foundations; functional genomics; Funding; Future; Generations; Genetic; Genome; genomic data; Genomic medicine; Genomics; Goals; graduate student; Growth; Health Insurance Portability and Accountability Act; high school; High School Student; Informatics; innovation; Institution; Journals; Knowledge; knowledge base; Laboratories; Laboratory Research; Leadership; Learning Module; life-long learning; Maine; Malignant Neoplasms; member; Mentors; Mentorship; Molecular Biology; New Mexico; Oncologist; oncology; organizational structure; outreach program; Participant; Patients; Postdoctoral Fellow; Procedures; Program Development; programs; Provider; recruit; Research; Research Personnel; Research Training; Resource Informatics; Resources; Rural; Scientist; skills; Southwest Oncology Group; Strategic Planning; student mentoring; summer student; Testing; The Jackson Laboratory; tool; Training; Training Activity; training opportunity; Training Programs; Translational Research; tumor; undergraduate student; Universities; virtual; Work; ","Cancer Education and Career Enhancement Core","034196","NCI","Subcommittee H - Clinical Groups ","7969","","34","155459","114174","","269633"
"9854056","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:261032\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","8556573; ","CHUANG, JEFFREY HSU-MIN;","","","","Abbreviations; Achievement; Address; Algorithms; analysis pipeline; analytical tool; anticancer research; Architecture; Area; Artificial Intelligence; Big Data Methods; Bioinformatics; Biometry; Cancer Biology; Cancer Center; cancer genomics; Cancer Research Infrastructure; Cancer Research Project; Cells; Clinical; Collection; Complex; Computational Science; Computer software; Computers; Consult; Core Grant; cost; Data; Data Analyses; data portal; Data Science; Data Set; Databases; design; Development; experience; Experimental Designs; Faculty; Funding; Genomics; Goals; High Performance Computing; Hybrids; Individual; Information Technology; Infrastructure; Laboratories; Machine Learning; Malignant Neoplasms; member; Mentorship; metabolomics; multidisciplinary; Names; Ownership; Procedures; programs; Quantitative Trait Loci; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; response; scientific computing; Scientist; Services; skills; software development; Software Engineering; Statistical Methods; statistics; System; tool; Training; translational cancer research; Tumor Biology; ","Computational Sciences Shared Resource","034196","NCI","Subcommittee H - Clinical Groups ","7970","","34","150500","110532","","261032"
"9854057","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:258305\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","8152603; ","SHULTZ, LEONARD ;","","","","Abbreviations; animal care; Animal Husbandry; animal resource; anticancer research; Biology; Breeding; Cancer Center; Cancer Center Support Grant; Cancer Model; Collaborations; Complex; Consultations; Core Grant; Coupled; design; Development; Developmental Biology; Discipline; Engineering; Engraftment; experience; experimental study; Faculty; Generations; Genetic; Genetic Engineering; genetic manipulation; genetic resource; Genetic Variation; Genetically Engineered Mouse; Genome; Goals; humanized mouse; improved; Infrastructure; interest; Laboratories; Libraries; Maintenance; Malignant Neoplasms; member; model development; Modeling; Modification; Molecular; Molecular Biology; mouse model; Mus; Names; neoplasm resource; Neurobiology; novel; Patients; Performance; Phenotype; Play; Primary Neoplasm; Process; Recording of previous events; repository; Reproductive Biology; Research; research and development; Research Personnel; Resource Development; Resource Sharing; Resources; Role; Science; Services; single cell technology; Technical Expertise; Technology; tool; Validation; virtual; Xenograft Model; Xenograft procedure; ","Cancer Models Development Shared Resource","034196","NCI","Subcommittee H - Clinical Groups ","7971","","34","148928","109377","","258305"
"9858342","R01","EY","5","N","03/24/2020","02/01/2020","01/31/2021","867","R01EY029788","SCHOOL OF MEDICINE & DENTISTRY","PA-18-351","5R01EY029788-02","NEI:385000\","Non-SBIR/STTR RPGs","2020","NATIONAL EYE INSTITUTE","","ROCHESTER","UNITED STATES","NEUROSCIENCES","25","041294109","US","7047101","UNIVERSITY OF ROCHESTER","NY","146270140","PROJECT NARRATIVE Humans critically rely on a tiny region of the retina, the foveola, to inspect objects of interest. By examining how foveal processing interacts with high-resolution control of attention and microscopic eye movements, this research will advance understanding of the mechanisms underlying ?ne spatial vision in humans and may lay the basis for new treatment approaches for impairments in foveal functions.","10585953; ","POLETTI, MARTINA ;","WIGGS, CHERI","02/01/2019","01/31/2024","Area; Attention; attentional control; Attenuated; Behavior; cost; Crowding; design; Discrimination; Drops; Eye; Eye Movements; gaze; Goals; Human; Ice; Impairment; Individual; interest; Knowledge; Link; Location; Measures; Methodology; Methods; Microscopic; Monitor; Moon; Motion; Motor; motor control; Neurons; Nose; oculomotor; Outcome; Pattern; Performance; Peripheral; Physiological; Play; Preparation; prevent; Procedures; Rehabilitation therapy; Research; Resolution; Retina; Retinal; Retinal Cone; retinal rods; retinal stimulation; Role; Saccades; sample fixation; spatial vision; Stimulus; Sum; synergism; Time; Uncertainty; Ursidae Family; Vision; Visual; Visual Acuity; Visual Fields; visual map; visual motor; visual process; visual processing; Work; ","Vision, Attention and Eye Movements at the Scale of the Foveola","029788","SPC","Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section ","","","02","250000","135000","385000",""
"9867658","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:505878\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Accounting; Advocacy; anticancer research; Area; authority; Award; base; Basic Science; Budgets; Cancer Center; Cancer Center Support Grant; Cancer Control; cancer prevention; cancer research center director; cancer therapy; Charge; Clinical Research; Clinical Services; Clinical Trials; Colorado; Communication; Communities; Contracts; cost; Development; Diagnosis; Discipline; Doctor of Philosophy; Education; Ensure; Evaluation; Facilities and Administrative Costs; Faculty Recruitment; General Population; Goals; Grant; Growth; Human Resources; Individual; Industry; Infrastructure; Institution; interest; Leadership; Malignant Neoplasms; Management Information Systems; Medical center; member; Mission; Modification; Monitor; Morbidity - disease rate; mortality; multidisciplinary; new technology; Occupational activity of managing finances; Office of Administrative Management; operation; Play; Policies; Population Research; Population Sciences; Prevention; Procedures; programs; Public Relations; Publications; recruit; Research; research and development; Resource Sharing; Resources; Role; Science; Services; Strategic Planning; The University of Colorado Cancer Center; Time; Training and Education; Training Support; Translational Research; Universities; Vision; web site; ","Administrative Core","046934","NCI","Subcommittee H - Clinical Groups ","5056","","32","325655","180223","","505878"
"9867667","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:315958\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","anticancer research; Area; base; Bioinformatics; Biological Assay; Biological Markers; Budgets; Businesses; Cancer Center; Cancer Center Support Grant; Capillary Electrophoresis; Cells; Clinical; Clinical Laboratory Improvement Amendments; Clinical Research; Clinical Trials; Colorado; Communities; Complex; Computer Assisted; Consultations; Coupled; Custom; Cytogenetic Analysis; Cytogenetics; Data; Data Analyses; data management; Data Quality; Data Set; design; Diagnosis; Dideoxy Chain Termination DNA Sequencing; disease diagnosis; Doctor of Philosophy; Documentation; Education; Ensure; Environment; Equipment; Evaluation; Experimental Designs; Fees; fluorescence microscope; Fluorescent in Situ Hybridization; Funding; Future; G-Banding; Generations; Genes; Goals; good laboratory practice; Histologic; Histology; imaging system; In Situ Hybridization; Individual; innovation; Instruction; instrument; interest; Interphase; Leadership; Logistics; meetings; member; Metaphase; Microdissection; Microsatellite Instability; Microtome - medical device; Molecular; Molecular Analysis; molecular pathology; Molecular Profiling; Nature; next generation; next generation sequencing; Nucleic Acids; outreach; Pathologist; Patients; Phenotype; Play; Ploidies; pre-clinical; Pre-Clinical Model; predicting response; Prediction of Response to Therapy; predictive marker; Price; Process; prognostic; programs; prospective; Publications; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; response; Reverse Transcriptase Polymerase Chain Reaction; RNA; Role; Sampling; Scanning; Services; Specimen; Spectral Karyotyping; Stains; Surveys; Suspensions; System; Technical Degree; Technical Expertise; Technology; Testing; Time; tissue processing; Tissue Sample; Tissue Stains; Tissues; Training; Translational Research; tumor; Universities; Update; user-friendly; Validation; Work; ","Molecular Pathology Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5064","","32","203520","112438","","315958"
"9867672","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:439957\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Adult; African American; American College of Radiology Imaging Network; Area; authority; Award; base; Cancer Center Support Grant; cancer clinical trial; Cancer Patient; cancer site; Case Study; Catchment Area; central database; Chemoprevention; Clinical; Clinical Data; clinical data warehouse; clinical investigation; Clinical Investigator; Clinical Management; Clinical Protocols; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Colorado; Complement; Consultations; County; Data; data management; Data Quality; demographics; Development; Education; Educational Curriculum; Enrollment; Ensure; Faculty; Female; Funding; Geography; Goals; Grant; Growth; Health; Health care facility; health data; Health Personnel; high risk; Hispanics; Hospitals; Hour; improved; Incidence; Industrialization; Infrastructure; innovation; Institution; Intervention; Intervention Studies; Investigational Therapies; Lead; Leadership; Malignant Neoplasms; member; Monitor; Nurses; Nursing Faculty; operation; outreach; participant safety; Patients; Peer Review; Phase; Phase I Clinical Trials; Phase II Clinical Trials; Physician Executives; Policies; Population; population health; Population Sciences; Positioning Attribute; programs; Protocols documentation; Quality Control; Recording of previous events; Reporting; Research; Research Personnel; research study; Research Support; Resources; Rural; Safety; Services; Site; socioeconomics; Southwest Oncology Group; Structure; success; System; Time; tool; Training; Training and Education; trend; Universities; Update; Woman; Work; ","Clinical Protocol & Data Management","046934","NCI","Subcommittee H - Clinical Groups ","5069","","32","283262","156695","","439957"
"9867681","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:71335\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","actionable mutation; Address; Adverse effects; animal imaging; anticancer research; Area; base; Basic Science; biobank; Bioinformatics; Biological Markers; Biology; biomarker validation; Biometry; Cancer Burden; Cancer Center; Cancer Center Support Grant; cancer chemoprevention; Cancer Control; Cancer Etiology; Cancer Patient; cancer prevention; cancer stem cell; cancer therapy; career; career development; Catchment Area; Cell Culture Techniques; Cell Line; Cessation of life; Chemoprevention; Clinic; Clinical; clinical Diagnosis; Clinical Trials; cohort; Collaborations; Colorado; Dental; design; Development; Developmental Therapeutics Program; Diagnosis; Discipline; Early Diagnosis; Education; Environmental Risk Factor; Etiology; falls; Female; Flow Cytometry; Fostering; functional genomics; Funding; Future; Genetic; Genetically Engineered Mouse; Genomics; Goals; Grant; Head and Neck Cancer; head and neck cancer patient; Head and neck structure; Head Cancer; Hospitals; human disease; Human papilloma virus infection; Human Papillomavirus; Immunotherapy; improved; in vivo Model; Incidence; innovation; Institution; interest; International; Intervention; Investigation; Investigational Therapies; Leadership; Lesion; Lung; lung development; Lung nodule; Malignant neoplasm of lung; Malignant Neoplasms; medical schools; Medicine; meetings; member; Mentors; Mentorship; Mission; Modeling; Molecular; Molecular Chaperones; Molecular Diagnosis; molecular oncology; molecular pathology; molecular targeted therapies; monoclonal antibody production; Morbidity - disease rate; mortality; Mutation; National Heart, Lung, and Blood Institute; Nature; Neck Cancer; next generation; non-smoking; novel; novel strategies; novel therapeutic intervention; oncology program; Pathogenesis; Patients; Peer Review; personalized medicine; Pharmacology; Population Sciences; Pre-Clinical Model; Premalignant; prevent; Prevention; Program Development; programs; Protein Tyrosine Kinase; Proteins; Public Health; Publications; Research; Research Activity; Research Personnel; Resistance; resistance mechanism; Resource Sharing; Risk; Risk Factors; Risk stratification; Role; Science; Scientist; SECTM1 gene; Signal Transduction Pathway; Smoking; Squamous Cell Lung Carcinoma; stem cell biology; survivorship; Testing; therapeutic evaluation; therapeutic target; tissue culture; Tissues; Tobacco; Tobacco Dependence; Tobacco-Related Carcinoma; Training; Translating; Translations; Treatment Side Effects; treatment strategy; tumor; Tumor-Derived; Universities; Xenograft Model; Xenograft procedure; ","Lung, Head & Neck Cancers Program","046934","NCI","Subcommittee H - Clinical Groups ","5076","","32","46206","25129","","71335"
"9870946","F31","MH","5","N","03/23/2020","03/09/2020","09/08/2020","242","F31MH116588","SCHOOLS OF MEDICINE","PA-16-309","5F31MH116588-03","NIMH:18928\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","STANFORD","UNITED STATES","ANATOMY/CELL BIOLOGY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943052004","Project Narrative A detailed understanding of the molecular mechanisms that contribute to autism spectrum disorder (ASD) is urgently needed to improve diagnosis and develop effective treatments. The goal of this project is to provide a detailed molecular profile of autism caused by novel, loss-of-function mutations the neuron-specific chromatin remodeling gene, BAF53B. Since chromatin remodeling complexes have been implicated in a variety of neurodevelopmental disorders, we expect that our findings will facilitate a nuanced understanding of chromatin remodeling function in the healthy and diseased brain. !","12623295; ","WENDERSKI, WENDY CHRISTINE;","VAN'T VEER, ASHLEE V","03/09/2018","09/08/2020","ACTL6A gene; ACTL6B gene; Adult; Alleles; Area; ATAC-seq; autism spectrum disorder; autistic; Autopsy; behavior test; Behavioral; Biochemistry; Bioinformatics; Brain; Brain Diseases; career; ChIP-seq; Chromatin; chromatin remodeling; Chromatin Remodeling Factor; Code; cohort; Complex; Data; Defect; Development; Diagnosis; Disease; disease-causing mutation; Doctor of Philosophy; effective therapy; Electrophysiology (science); Embryo; embryonic stem cell; Epigenetic Process; experience; experimental study; Failure; Family; Gene Expression; Gene Expression Regulation; Genes; Genetic screening method; Genetic Transcription; Genome; genome-wide; Genomics; Goals; Hippocampus (Brain); Human; improved; Inheritance Patterns; Inherited; insight; liquid chromatography mass spectrometry; Long-Term Potentiation; loss of function; loss of function mutation; Measures; Mediating; Membrane; Methods; Microarray Analysis; Mitotic; Modeling; Molecular; Molecular Profiling; mRNA Expression; mRNA sequencing; Mus; Mutate; Mutation; Nervous system structure; neural stimulation; neurodevelopment; Neurodevelopmental Disorder; Neuronal Plasticity; Neurons; next generation sequencing; novel; Nucleosomes; null mutation; Pathway interactions; patient subsets; Patients; Phenotype; Play; Polycomb; Process; Proteins; Proteomics; Protocols documentation; Regulation; relating to nervous system; response; Role; Site; Slice; SMARCA2 gene; Social Behavior; Syndrome; Testing; Therapeutic Intervention; Training; transcription factor; Transcriptional Regulation; transcriptome sequencing; Treatment Efficacy; ","Defining the molecular basis of autism caused by inherited null mutations in BAF53B","116588","ZRG1","Special Emphasis Panel ","","","03","18928","","18928",""
"9873038","R01","GM","5","N","03/24/2020","03/01/2020","02/28/2021","859","R01GM067945","SCHOOLS OF MEDICINE","PA-16-160","5R01GM067945-17","NIGMS:508500\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","ANATOMY/CELL BIOLOGY","07","047006379","US","3212902","HARVARD MEDICAL SCHOOL","MA","021156027","Project Narrative The ubiquitin system is an intense research area with great promise for the improvement of human health. In addition to its critical role in normal physiology, malfunctions in ubiquitin biology have been implicated as a contributing factor in the causation of many diseases as diverse as diabetes, cancer, and Alzheimer's disease. This proposal will develop new mass spectrometry-based technologies to allow sample multiplexing such that up to 32 clinical or experimental proteomes can be analyzed simultaneously. These technologies will revolutionize our ability to profile hundreds to thousands of individual samples within a timeframe of days or weeks, respectively. 0","1879268; ","GYGI, STEVEN P;","BARSKI, OLEG","05/15/2003","02/28/2021","Address; Algorithms; Alzheimer's Disease; Amino Acids; Area; base; Benchmarking; Biochemical; Biological; Biological Assay; Biology; Brown Fat; Bulla; Cell Nucleus; Cells; Censuses; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; cohort; combinatorial; Complex; cost; Data Set; Databases; Defect; Detection; Development; Diabetes Mellitus; Disease; Encapsulated; Enzymes; Etiology; Experimental Designs; experimental study; FRAP1 gene; Generations; Genes; genetic variant; Genomics; Goals; Golgi Apparatus; Grant; Health; Heart; Human; improved; Individual; insight; Intelligence; Intervention; Ions; Isotopes; Knowledge; Liver; Malignant Neoplasms; Mass Spectrum Analysis; Measurement; Measures; member; Metabolic; Microtubules; Mitochondria; Modeling; Modification; Monitor; Mus; Neurodegenerative Disorders; novel; Organelles; overexpression; Pancreas; Pathway interactions; Peptides; peroxisome; Phosphorylation; Physiology; protein expression; Proteins; Proteome; Proteomics; Quantitative Trait Loci; Reagent; Reporter; Research; Role; Sampling; Scanning; Schedule; stable isotope; Structure; Surveys; synthetic peptide; System; Technology; theories; Therapeutic Intervention; Time; Tissues; Ubiquitin; ubiquitin ligase; Work; ","New and Disruptive Technologies to Study Ubiquitin Biology through Sample Multiplexing","067945","EBIT","Enabling Bioanalytical and Imaging Technologies Study Section ","","","17","300000","208500","508500",""
"9873065","R01","HL","5","N","03/28/2020","03/01/2020","02/28/2021","837","R01HL141429","SCHOOLS OF MEDICINE","PA-16-160","5R01HL141429-03","NHLBI:754620\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PORTLAND","UNITED STATES","OBSTETRICS & GYNECOLOGY","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","PROJECT NARRATIVE The objective of this research is to improve care and outcomes for children suffering out-of-hospital cardiac arrests (OHCA). Policies, practices, and training requirements (systems factors) for prehospital care of children are set locally and vary nationwide. This proposal will explore nationwide factors to quantify the occurrence and variation of adverse safety events in pediatric OHCA, understand the impacts and mechanisms by which these factors affect individual providers and contribute to adverse safety events and explore how provider stress affects performance in pediatric vs adult cardiac arrest cases.","1861404; ","GUISE, JEANNE-MARIE ;","EGERSON, D'ANDREA R","04/01/2018","02/28/2022","Academy; Adult; Adverse event; Affect; Area; base; care delivery; care outcomes; care systems; Caring; Cause of Death; Child; Child Care; Childhood; Clinical; cognitive load; Communities; Critical Care; Critically ill children; Data Quality; Education; Emergency Care; Emergency medical service; Emergency Situation; Epidemiology; Event; evidence base; experience; Family; Funding; Goals; Heart Arrest; high risk; Hospitals; improved; improved outcome; In Situ; Individual; injured children; innovative technologies; Institute of Medicine (U.S.); Intervention; Knowledge; Lead; Life; Measures; Medical; Medical Errors; Medicine; Methods; metropolitan; National Institute of Child Health and Human Development; Nature; out-of-hospital cardiac arrest; Outcome; Patient Care; patient safety; Pediatric cohort; Pediatric Hospitals; Performance; Policies; Pre-hospital setting; Pre-hospitalization care; Prevalence; prevent; preventable death; Prevention; Process; programs; Provider; Quality of Care; Registries; Reporting; repository; Research; Resources; Resuscitation; Safety; Serious Adverse Event; service providers; simulation; Site; Source; Stress; System; Training; trauma care; United States; Variant; Work; Workplace; ","Understanding and preventing adverse safety events in pediatric out-of-hospital cardiac arrests","141429","HSOD","Health Services Organization and Delivery Study Section ","","","03","510666","243954","754620",""
"9875461","R01","EY","5","N","03/27/2020","03/01/2020","02/28/2021","867","R01EY026640","","PA-13-302","5R01EY026640-04","NEI:488559\","Non-SBIR/STTR RPGs","2020","NATIONAL EYE INSTITUTE","","BOSTON","UNITED STATES","","08","073826000","US","6948301","SCHEPENS EYE RESEARCH INSTITUTE","MA","021142508","Project Narrative A major unmet need for the treatment of bacterial keratitis is a method of sustained ocular drug delivery that could improve treatment efficacy. This proposal seeks to test an antibiotic-eluting therapeutic contact lens for the treatment of bacterial keratitis.","9638123; ","CIOLINO, JOSEPH B.;","MCKIE, GEORGE ANN","03/01/2017","02/28/2021","Address; Anti-Bacterial Agents; Antibiotic Resistance; Antibiotics; Antifungal Agents; Astigmatism; Bacteria; bacterial resistance; biomaterial compatibility; Blindness; Ciprofloxacin; Clinical; comparative efficacy; compliance behavior; Contact Lenses; Cornea; corneal scar; cytotoxic; cytotoxicity; design; Dexamethasone; Dose; Drops; Drug Delivery Systems; Effectiveness; efficacy evaluation; Elasticity; Ensure; Eye; Eyedrops; FDA approved; Film; fluoroquinolone resistance; Fluoroquinolones; Formulation; Generations; Glaucoma; Goals; Hour; Hydrogels; Hydrophobicity; Image; improved; In Vitro; Infection; innovation; Institutes; Keratitis; Laboratories; Latanoprost; Left; lens; Light; Medical; Methods; Minimum Inhibitory Concentration measurement; Monkeys; nonhuman primate; Operative Surgical Procedures; Oryctolagus cuniculus; Pharmaceutical Preparations; physical property; Physiologic Intraocular Pressure; Polymers; Pseudomonas aeruginosa; Regimen; Research; Resistance; Safety; Side; standard of care; Staphylococcus aureus; Steroids; Testing; Therapeutic; Thinness; Tissues; Tobramycin; tomography; Topical Antibiotic; Treatment Efficacy; Vancomycin; Vision; Water; Work; ","Antibiotic eluting contact lenses for the treatment of bacterial keratitis","026640","ZRG1","Special Emphasis Panel ","","","04","255496","233063","488559",""
"9881254","R21","AR","5","N","03/25/2020","03/01/2020","02/28/2021","846","R21AR075150","SCHOOLS OF MEDICINE","PA-18-489","5R21AR075150-02","NIAMS:178200\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","DALLAS","UNITED STATES","INTERNAL MEDICINE/MEDICINE","30","800771545","US","578404","UT SOUTHWESTERN MEDICAL CENTER","TX","753909105","Project Narrative Spondyloarthritis represents a major category of chronic inflammatory rheumatic disease with a prevalence comparable to rheumatoid arthritis, but with an earlier age of onset. It is known that in general, cells that respond to the cytokine IL-23 are known to play a critical role in the development of spondyloarthritis, but little is known about the specific identity of these cells or their characteristics. This study will develop and exploit a unique rodent model to break new ground in identifying and characterizing the IL-23-responsive cells that cause spondyloarthritis, and this new insight may well lead to better treatment, and potentially even practical means of prevention.","1866799; ","TAUROG, JOEL D;","MAO, SU-YAU","03/01/2019","02/28/2021","Age of Onset; Alleles; Ankylosing spondylitis; Backcrossings; beta-2 Microglobulin; Biological Assay; Biological Models; Categories; Cell surface; cell type; Cells; Cellular Immunology; Characteristics; Chronic; CRISPR/Cas technology; cytokine; Cytokine Gene; Development; Disease; Disease model; DNA; Dose; Effector Cell; Exhibits; Exons; experimental study; Expression Profiling; Flow Cytometry; Fluorescence; Gene Expression; Generations; Genes; Genetic Risk; Genome; Genomics; Goals; Heterozygote; Histocompatibility; Histology; HLA-B27 Antigen; Homozygote; Human; Human Characteristics; IL17 gene; Immunofluorescence Immunologic; In Vitro; in vitro Assay; in vivo; incomplete Freund's adjuvant; Infertility; Inflammation; Inflammatory; Injections; insight; Interleukin-17; interleukin-23; Knock-in; Lamina Propria; Lead; Light; Limb structure; Lymphoid Tissue; Mediating; Mesentery; Methods; Molecular; mouse model; Mus; Mycobacterium tuberculosis; Odds Ratio; offspring; Pathogenesis; Pathogenicity; Pathology; Pathway interactions; Peripheral Blood Mononuclear Cell; Phase; Phenotype; Play; Population; Predisposition; Prevalence; Prevention; Process; Production; Rattus; receptor; Receptor Cell; Reporter; Research Design; Research Proposals; Reverse Transcriptase Polymerase Chain Reaction; Rheumatism; Rheumatoid Arthritis; RNA; Rodent Model; Role; Signal Transduction; Site; Spinal Diseases; Spondylarthritis; stem; Stem cells; Structure; Surface; System; Testis; therapeutic target; Tomatoes; Transgenes; Transgenic Mice; Transgenic Organisms; Work; ","Genome-targeted IL-23 receptor reporter rats for studying HLA-B27-dependent spondyloarthritis","075150","ACTS","Arthritis, Connective Tissue and Skin Study Section ","","","02","110000","68200","178200",""
"9883625","F31","DA","5","N","03/23/2020","03/10/2020","03/09/2021","279","F31DA047018","GRADUATE SCHOOLS","PA-18-671","5F31DA047018-02","NIDA:39948\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","RICHMOND","UNITED STATES","PSYCHOLOGY","04","105300446","US","353201","VIRGINIA COMMONWEALTH UNIVERSITY","VA","232980568","Project Narrative Electronic cigarette (ECIG) use has increased among smokers and nicotine-naïve individuals, and many ECIG users report using sweet, non-tobacco flavored ECIG liquids that often contain nicotine and added sweeteners. This project will examine the influence an ECIG liquid sweetener and nicotine on clinical measures of abuse liability and analytical measures of ECIG toxicant exposure. Results from this study have the potential to inform clinicians and policymakers regarding factors that influence ECIG initiation and dependence and may be useful in policies and manufacturing guidelines aimed at maximizing overall public health.","14601444; ","MALONEY, SARAH FRANCIS;","WALTON, KEVIN","03/10/2019","03/09/2022","Address; Aerosols; Affect; Aldehydes; Area; base; Behavior; Behavioral; behavioral economics; behavioral pharmacology; Berry; Blood; Candy; career; Categories; Chemicals; Cigarette; Cigarette Smoker; Clinical; clinical epidemiology; Country; Dependence; design; Devices; Drug abuse; Electronic cigarette; electronic cigarette use; electronic cigarette user; electronic liquid; Elements; Epidemiology; falls; Food; Fruit; Furans; Guidelines; Health; Heating; Human; Ice Cream; Individual; Inhalation; Irritants; Laboratory Research; Learning; liquid nicotine; Liquid substance; Measures; Menthol; Methodology; Methods; multidrug abuse; Nicotine; Nicotine Dependence; nicotine user; novel; Outcome; Outcome Measure; Participant; Pharmaceutical Preparations; Policies; Prevalence; primary outcome; Procedures; Psychopharmacology; Public Health; Publishing; Records; Regulation; Reporting; Research; Research Personnel; Research Training; respiratory; Risk; Self Administration; Smoker; Sweetening Agents; Techniques; Technology; Tobacco; tobacco products; toxicant; Toxicant exposure; Toxicology; Training; Ursidae Family; vapor; Work; ","The effect of an electronic cigarette (ECIG) sweetener, sucralose, on ECIG abuse liability","047018","ZRG1","Special Emphasis Panel ","","","02","39948","","39948",""
"9884726","R01","AI","5","N","03/24/2020","03/01/2020","02/28/2021","855","R01AI142662","SCHOOLS OF MEDICINE","RFA-AI-17-039","5R01AI142662-02","NIAID:1218191\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","PITTSBURGH","UNITED STATES","GENETICS","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","Narrative Children living with HIV are much more susceptible to Mycobacterium tuberculosis, which causes tuberculosis, for reasons that are not well understood. We will use nonhuman primates to model HIV/M. tuberculosis coinfection of preadolescent children, determine how the virus affects a subset of innate immune cells, and test whether the ability of immunocompromised animals to fight TB is improved if we boost those cells. We will also examine these same cells in children from Myanmar who are infected with HIV, M. tuberculosis, or both.","9476960; 6362174; 10439191 (contact); ","NDHLOVU, LISHOMWA C; OCONNOR, SHELBY L; SCANGA, CHARLES A. (contact);","MILLER, JUDITH A","03/04/2019","02/29/2024","adaptive immune response; adaptive immunity; Adolescent; Adult; Affect; Animal Model; Animals; anti-PD-1; anti-PD1 antibodies; Antibodies; antiretroviral therapy; Bacteria; Biological; Blood; CD4 Positive T Lymphocytes; Cell physiology; cell type; Cells; Child; Childhood; Chronic; Clinic; Clinical Data; Clinical/Radiologic; co-infection; Cohort Studies; Containment; cytokine; Cytotoxic T-Lymphocytes; Data; Defect; Disease; Event; exhaustion; fighting; Frequencies; global health; Goals; Granuloma; Harvest; Health; HIV; HIV Infections; HIV/TB; human disease; Humoral Immunities; Immune; immune function; Immune response; Immune system; Immunity; Immunocompromised Host; Impairment; improved; improved functioning; Infection; Infection Control; insight; Lung; Macaca; Measures; Mediating; Methods; Modeling; Mucous Membrane; Myanmar; Mycobacterium tuberculosis; nonhuman primate; novel; Outcome; pathogen; Pathologic; Pediatric cohort; pediatric human immunodeficiency virus; Peripheral; Peripheral Blood Mononuclear Cell; Phenotype; Population; preadolescence; Predisposition; recruit; Resistance; response; Risk; Risk Factors; Role; Severities; SIV; SLEB2 gene; Specimen; T-Lymphocyte; Testing; Tuberculosis; tuberculosis granuloma; Virus; ","Effects of HIV SIV on unconventional T cells in immunity to M. tuberculosis in pre adolescents","142662","ZRG1","Special Emphasis Panel ","","","02","1033787","184404","1218191",""
"9888404","R01","HL","5","N","03/26/2020","03/01/2020","02/28/2021","838","R01HL132996","SCHOOLS OF MEDICINE","PA-16-160","5R01HL132996-04","NHLBI:458292\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NEW YORK","UNITED STATES","INTERNAL MEDICINE/MEDICINE","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","Project Narrative  Abnormal separation of the lung and trachea from the foregut leads to multiple foregut malformations  including the common birth defect tracheoesophageal fistula which affects 1/2000-­1/3500 newborns. This birth  defect  compromises  lung  function  at  all  ages.  Although  multiple  genes  have  been  associated  with  the  formation  of  the  defect,  there  is  a  gap  in  the  understanding  of  the  underlying  cellular  and  molecular  mechanisms. Here, we use a combination of organ culture, frog and mouse models to address the issue. The  proposal will provide novel insight into fundamental mechanisms with broad scientific and clinical implications.    ","9365956; ","QUE, JIANWEN ;","LIN, SARA","03/01/2017","02/28/2021","Abbreviations; Ablation; Address; Adolescent; Adult; Affect; Age; Animal Model; Back; Behavior; Binding; Biological Assay; Cell Proliferation; Cephalic; Chromosome Deletion; Clinical; Congenital Abnormality; Data; Defect; Development; Developmental Process; Down-Regulation; Epithelial; Epithelium; Esophageal Atresia; Esophagus; Event; Extracellular Matrix; Extracellular Matrix Proteins; Family member; Fos-Related Antigens; Genes; Genetic; Genetic Models; Genetic Transcription; insight; Internal Ribosome Entry Site; Intervention; Knowledge; Link; Lobe; loss of function; Luciferases; Lung; lung development; malformation; migration; Modeling; Molecular; Molecular Genetics; Morbidity - disease rate; mouse model; Movement; Mus; mutant; Newborn Infant; novel; Operative Surgical Procedures; Organ Culture Techniques; Pathogenesis; Patients; Play; Primitive foregut structure; Primordium; Process; progenitor; promoter; Rana; Regulation; Respiration; respiratory; Respiratory physiology; Respiratory System; Role; Signal Pathway; Stem cells; Testing; tissue culture; Trachea; Tracheoesophageal Fistula; transcription factor; transcriptome sequencing; ","Mechanism of Respiratory System-Esophageal Separation","132996","LIRR","Lung Injury, Repair, and Remodeling Study Section ","","","04","286174","172118","458292",""
"9894764","UG1","CA","5","N","03/25/2020","03/01/2020","02/28/2021","395","UG1CA233259","SCHOOLS OF MEDICINE","RFA-CA-17-061","5UG1CA233259-02","NCI:750806\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","ATLANTA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","PROJECT NARRATIVE The ECOG-ACRIN Integrated Thoracic Malignancies Translational Sciences Center brings together a team of outstanding researchers in both translational and clinical sciences to discover biomarkers and develop novel treatment approaches for lung cancer within the National Clinical Trials Network.","1885529; 8576769 (contact); 1880097; ","CARBONE, DAVID P.; RAMALINGAM, SURESH S (contact); RUDIN, CHARLES M;","MOONEY, MARGARET M","03/14/2019","02/28/2025","actionable mutation; American College of Radiology Imaging Network; Area; Award; Biological Markers; biomarker development; biomarker discovery; biomarker evaluation; biomarker-driven; BRAF gene; cell free DNA; Center for Translational Science Activities; checkpoint inhibition; chemotherapy; Chest; Clinical; clinical care; Clinical Data; Clinical Sciences; Clinical Trials; Clinical Trials Network; cohort; Collaborations; Combined Modality Therapy; companion diagnostics; Detection; Development; Disease; drug development; Early Diagnosis; Eastern Cooperative Oncology Group; EGFR inhibition; Enrollment; Epidermal Growth Factor Receptor; epigenetic marker; epigenomics; Excision; Funding; Genomics; Goals; Grant; Immunologic Markers; Immunotherapy; improved; improved outcome; inhibitor/antagonist; innovation; Institution; Leadership; Lung; lung cancer screening; Lung Neoplasms; lung small cell carcinoma; Malignant neoplasm of lung; Malignant neoplasm of thorax; Molecular; Molecular Abnormality; Molecular Analysis; Mutation; National Clinical Trials Network; next generation; Non-Small-Cell Lung Carcinoma; novel; novel marker; novel strategies; Operative Surgical Procedures; Patient-Focused Outcomes; Patients; PDCD1LG1 gene; personalized medicine; phase 3 study; Pilot Projects; Plasma; Plasma Cells; Play; Precision Medicine Initiative; Precision therapeutics; Prevention; Process; programs; prospective; Proteomics; Recurrence; Research; Research Personnel; Residual Neoplasm; Resistance; Risk; Risk stratification; Role; ROS1 gene; Science; Specimen; STK11 gene; targeted agent; targeted treatment; Technology; Testing; Time; Translational Research; tumor; Work; ","ECOG-ACRIN Thoracic Malignancies Integrated Translational Science Center","233259","ZCA1","Special Emphasis Panel ","","","02","686322","64484","750806",""
"9911982","F31","HD","5","N","03/04/2020","03/25/2020","03/24/2021","865","F31HD098816","SCHOOLS OF MEDICINE","PA-18-671","5F31HD098816-02","NICHD:45520\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","ATLANTA","UNITED STATES","ANATOMY/CELL BIOLOGY","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","PROJECT NARRATIVE:  Only 10-20% of autism spectrum disorders (ASDs) are linked to genetic causes, raising the possibility of epigenetic contributions to ASDs. In the proposed research, we will assess an epigenetic mechanism that may underlie ASDs. This will enhance our understanding of the causes of these disorders and potentially contribute to therapeutic interventions.","14228042; ","SCOTT, ALYSSA MICHELLE;","KAU, ALICE S","03/25/2019","03/24/2022","Adult; advanced maternal age; Affect; Alleles; Anxiety; autism spectrum disorder; autistic; autistic behaviour; Behavior; Behavioral; Biological Assay; blastocyst; Caenorhabditis elegans; Caring; Cells; ChIP-seq; Clustered Regularly Interspaced Short Palindromic Repeats; Complex; cost; CRISPR/Cas technology; Data; Defect; density; Deposition; Development; Disease; Economic Burden; Embryo; Enzymes; epidemiologic data; Epigenetic Process; Exhibits; Failure; Family; Fertilization; Gene Expression; Genes; Genetic; Genetic Transcription; Goals; Golgi Apparatus; Heritability; Histone H3; histone methylation; Histones; Human; human model; In Vitro; Individual; Inherited; Intellectual functioning disability; interest; KDM1A gene; Knowledge; Lead; Link; Lysine; Mammals; Maternal Age; Mediating; Memory; Methylation; Mitotic; Modeling; mouse model; Mus; mutant; Mutation; Neuroanatomy; neurodevelopment; novel; offspring; Oocytes; Oogenesis; Outcome; Parental Ages; Patients; Pattern; Phenotype; Population; programs; Proteins; repetitive behavior; Research; Risk; Role; Series; Services; social; social communication; Social Interaction; Testing; Therapeutic Intervention; Time; transcriptome sequencing; Translating; Vertebral column; Work; ","The maternal role of hypomorphic LSD1 and its epigenetic contributions to neurodevelopment","098816","ZRG1","Special Emphasis Panel ","","","02","45520","","45520",""
"9921367","R21","EB","5","N","03/23/2020","02/01/2020","01/31/2021","286","R21EB027802","SCHOOLS OF VETERINARY MEDICINE","PAR-18-207","5R21EB027802-02","NIBIB:177500\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","ATHENS","UNITED STATES","NONE","10","004315578","US","676602","UNIVERSITY OF GEORGIA","GA","306021589","PROJECT NARRATIVE Mesenchymal stem cells (otherwise known as mesenchymal stromal cells or MSCs) hold great promise for treatment of bone related disorders due to their paracrine, multi-potential and immunosuppressive ef- fects. One major objective is to leverage the osteogenic differentiation of MSCs as potential treatments in metabolic bone disorders (e.g. osteoporosis, osteogenesis imperfecta, or hypophosphatasia) or localized bone defects. In these studies, we will develop and apply new, state of the art super-resolution optical imaging methods to monitor biologically relevant membrane alterations critical for MSC differentiation through the formation and release of matrix vesicles in living bone.","12592636; ","MORTENSEN, LUKE J.;","KING, RANDY LEE","05/01/2019","01/31/2022","3-Dimensional; base; Biological Assay; Biological Monitoring; bioprocess; bone; Bone Diseases; Bone Tissue; Caliber; Cartilage; cell behavior; Cell Differentiation process; Cell Therapy; Cells; Childhood; Clinical; Collagen; Crystallization; Defect; Deposition; Development; Devices; digital; Disease; Fiber; Flow Cytometry; Generations; Growth; Health; Human; Hydroxyapatites; Hypophosphatasia; Image; image reconstruction; imaging modality; Immunosuppression; Immunosuppressive Agents; improved; In Vitro; in vivo; Industry; Kinetics; Knowledge; Label; Lasers; Mammals; Measures; Membrane; Membrane Lipids; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; mesenchymal stromal cell; Metabolic Bone Diseases; Microscopy; Minerals; Modality; Monitor; multiphoton microscopy; Multivesicular Body; Mus; nanometer; nanoscale; novel imaging technology; optical imaging; Osteoblasts; Osteogenesis; Osteogenesis Imperfecta; osteogenic; Osteoporosis; Outcome; paracrine; Pathway interactions; Process; Production; Property; Protocols documentation; Refractive Indices; Research; Resolution; Role; Scanning; Scientific Advances and Accomplishments; second harmonic; Source; stem cell differentiation; Stem cell transplant; Surface; Technology; Therapeutic; three-dimensional visualization; Time; Tissues; transplant model; Vesicle; vesicular release; Work; ","Super resolution label-free imaging in highly scattering bone","027802","CMT","Cellular and Molecular Technologies Study Section ","","","02","125000","52500","177500",""
"9929050","R01","NS","5","N","03/25/2020","03/01/2020","02/28/2021","853","R01NS109023","","PA-18-484","5R01NS109023-02","NINDS:693635\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","BRONX","UNITED STATES","","14","081266487","US","10053556","ALBERT EINSTEIN COLLEGE OF MEDICINE","NY","104611900","Mobility impairments are often the most visible symptom of Multiple Sclerosis (MS) and the clinical hallmark of the disease. Falls are also very common in MS. The loss of mobility and notably the frequent falls in MS are associated with a multitude of adverse outcomes including disability and death. Recent epidemiological evidence suggests a shift in the peak prevalence of MS into older age groups, and this will likely coincide with co-occurring aging and MS-related declines in mobility and cognition. Research concerning brain systems of mobility and falls in MS, notably older adults with MS, is scarce. In aim 1 we will determine PFC HbO2 patterns associated with Single-Task-Walk (STW) and Dual-Task-Walk (DTW) in 120 MS patients and 120 controls. Using DTI, we will examine the moderating effect of white matter integrity on PFC HbO2 patterns assessed during active walking. In aim 2 we will use multi-modal neuroimaging methods to establish brain systems controlling STW and DTW in 120 MS patients and 120 healthy controls. In aim 3 we will use PFC HbO2 levels, assessed with fNIRS during DTW, to predict incident falls among 120 MS patients over a longitudinal follow-up (years 1-5). Identifying novel and potentially modifiable biomarkers of falls and mobility impairments in older adults with MS is of paramount epidemiological and clinical significance. Elucidating the mechanistic underpinnings of brain systems controlling mobility in older adults with MS will have a major impact on knowledge and important implications for treatment of mobility impairments and falls.","8752439; ","HOLTZER, ROEE ;","UTZ, URSULA","05/15/2019","02/29/2024","Address; Adult; Adverse effects; adverse outcome; Age; age group; Aging; Anisotropy; Atrophic; Attention; Axon; Basal Ganglia; Biological Markers; Brain; Cessation of life; Clinical; clinically significant; Cognition; Cognitive; cognitive control; cognitive function; density; design; Diagnosis; Diffuse; disability; Disease; Elderly; Epidemiology; executive function; Exhibits; fall risk; falls; follow-up; Gait; Gait speed; gray matter; Hemoglobin; Impaired cognition; Impairment; indexing; Individual; Knowledge; Lesion; Link; Locomotion; Memory; Methodology; Methods; mind control; motor control; multimodality; Multiple Sclerosis; multiple sclerosis patient; Near-Infrared Spectroscopy; Neurites; neuroimaging; novel; novel marker; Patients; Pattern; Performance; Prefrontal Cortex; Prevalence; processing speed; Radial; Recording of previous events; recruit; relating to nervous system; Research; Resources; Risk; Societies; Specific qualifier value; Symptoms; System; Thalamic structure; Thick; Walking; white matter; ","Brain predictors of mobility and falls in older adults with multiple sclerosis","109023","NAME","Neurological, Aging and Musculoskeletal Epidemiology ","","","02","429961","263674","693635",""
"9931304","R25","MH","5","N","03/24/2020","03/01/2020","02/28/2021","242","R25MH055929","","PAR-17-080","5R25MH055929-24","NIMH:207804\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","WOODS HOLE","UNITED STATES","","09","001933779","US","4822201","MARINE BIOLOGICAL LABORATORY","MA","025431015","Project Narrative The goal of the Summer Program in Neuroscience, Excellence and Success is to increase the tenacity and success of underrepresented minority (URM) groups in the neurosciences by creating role models and leaders committed to diversifying the research workforce in mental health. This course leverages the enriching environment at the Marine Biological Laboratory in Woods Hole, Massachusetts by networking students with the many world-renowned neuroscientists who convene at the MBL for research and teaching. This highly interactive course will offer students an intensive and rewarding immersion experience that integrates in-depth networking and mentoring with best practices for professional development, and incorporates research training focused on strengthening quantitative analytical skills in neuroscience.","1897697; ","HYMAN, LINDA E.;","VAN'T VEER, ASHLEE V","09/30/1995","02/29/2024","Action Potentials; Axon; base; Behavior; Biological; Capital; career; career development; career networking; Collaborations; Communication; Communities; Community Services; Competence; Coupled; Creativeness; design; Development; Educational process of instructing; Environment; environmental enrichment for laboratory animals; Ethics; evidence base; experience; Exposure to; Faculty; Family; Fostering; Future; Generations; Goals; Grant; Growth; health disparity; Home environment; Immersion; implicit bias; Individual; innovation; Internet; Laboratories; Laboratory Research; Leadership; Marines; Massachusetts; Measurable; Mental Health; Mentors; Mind; Minority Groups; minority scientist; Modeling; Modernization; Names; National Institute of Mental Health; Neurobiology; Neurosciences; Neurosciences Research; news; Nobel Prize; Oral; Outcome; Persons; Professional Practice; relating to nervous system; Reproducibility; Research; Research Personnel; Research Training; resilience; Rewards; role model; Running; Science; Scientist; Self Efficacy; skill acquisition; skills; Societies; Squid; Stereotyping; Students; success; summer program; symposium; Syndrome; System; Time; Training; Underrepresented Minority; Wood material; Writing; ","Summer Program in Neuroscience, Excellence and Success","055929","ZMH1","Special Emphasis Panel ","","","24","199874","7930","207804",""
"9939717","U54","MD","5","N","03/18/2020","02/01/2020","01/31/2021","","U54MD007597","","RFA-MD-17-006","5U54MD007597-32","NIMHD:100046\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","WASHINGTON","UNITED STATES","","98","056282296","US","3499801","HOWARD UNIVERSITY","DC","200590005","","15290487; ","WHITESELL, PETER LEFORT;","","","","actigraphy; acute chest syndrome; Acute Pain; Address; Adult; Adverse effects; adverse outcome; Affect; African American; Anemia; Arousal; Biological Markers; Blood Pressure; Bone necrosis; Breathing; burden of illness; Cardiovascular Diseases; cardiovascular disorder risk; Cardiovascular Physiology; Cardiovascular system; central pain; chronic pain; Clinic; Clinical; Cognitive Therapy; Comorbidity; Data; Disease; Drowsiness; Echocardiography; Endothelium; Epidemiology; Event; follow-up; Frequencies; functional disability; Functional disorder; General Population; Goals; health disparity; heart rate variability; Hour; Hypertension; improved; indexing; Inflammation; Inflammatory; Injury; Intervention; Laboratories; Left Ventricular Function; Life Expectancy; Measures; Medical; minority health; mortality; nocturnal Hypoxemia; Obesity; Obstructive Sleep Apnea; Pain; Pain Measurement; pain perception; pain sensitivity; pain symptom; patient population; Patient Self-Report; Patients; peripheral pain; Physiological; Pilot Projects; Polysomnography; Population; pressure; Prevalence; Pulmonary artery structure; Quality of life; Questionnaires; Recording of previous events; recruit; Research; response; Risk Factors; Role; Sampling; screening; Sensory; Severities; Sickle Cell; Sickle Cell Anemia; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleep Fragmentations; sleep quality; Sleeplessness; Snoring; standard of care; Stroke; Subgroup; Sympathetic Nervous System; symptomatology; Testing; Thrombosis; treatment effect; treatment response; Universities; vaso-occlusive pain; Venous; Walking; Work; ","Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to Treatment","007597","ZMD1","Special Emphasis Panel ","5951","","32","78511","43424","","100046"
"9942868","D43","TW","1","N","03/24/2020","03/26/2020","12/31/2020","989","D43TW011506","","PAR-19-243","1D43TW011506-01","FIC:233079\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","MAYWOOD","UNITED STATES","","07","791277940","US","4689203","LOYOLA UNIVERSITY CHICAGO","IL","601533328","Project Narrative The proposed fellowship program, a partnership between Loyola University Chicago and Ukrainian Catholic University, aims to provide doctoral and post-doctoral bioethics training to Ukrainian fellows who will conduct conceptual and empirical research on research ethics as well as educate and consult with researchers and research ethics committee members across Ukraine. The development of research ethics scholars is critical to the protection of human research participants and public trust in global research.","9812492; ","ANDERSON, EMILY E.;","SINA, BARBARA J","03/26/2020","12/31/2025","behavioral/social science; Bioethics; Chicago; Competence; Consultations; Development; Development Plans; Educational workshop; Ethical Issues; Ethical Review; Ethics; Fellowship; Foundations; Funding; global health; Government Agencies; Health; Individual; Institution; International; Lead; Leadership; Mentors; Methods; Persons; Positioning Attribute; Postdoctoral Fellow; Process; programs; Research; Research Activity; Research Design; Research Ethics; Research Personnel; Research Training; Scholarship; Solid; success; theories; Training; Training Programs; Ukraine; Universities; webinar; ","Loyola-Ukrainian Catholic University International Bioethics Research Training Program","011506","ZRG1","Special Emphasis Panel ","","","01","225493","7586","233079",""
"9948892","R21","AI","1","N","03/25/2020","03/25/2020","02/28/2021","855","R21AI150910","SCHOOLS OF MEDICINE","PA-19-053","1R21AI150910-01","NIAID:197500\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CHICAGO","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","005436803","US","6144650","NORTHWESTERN UNIVERSITY AT CHICAGO","IL","606113152","! Narrative The Peter Lab has identified a robust form of cell death that is induced by expression of toxic small RNAs carrying a ?kill code?. This proposal will investigate whether HIV kills infected cells with small RNAs carrying toxic sequences and sensitizes infected cells to cell death by inducing downregulation of protective small RNAs. The goal of this proposal is to develop a novel cure for AIDS based on eliminating all infected cells by activating this kill code.","6483309; ","PETER, MARCUS E.;","MCDONALD, DAVID JOSEPH","03/25/2020","02/28/2022","3' Untranslated Regions; Acquired Immunodeficiency Syndrome; Antioxidants; antiretroviral therapy; Apoptosis; Automobile Driving; Autophagocytosis; base; Basic Science; Biogenesis; CD4 Positive T Lymphocytes; Cell Death; Cell Death Induction; cell killing; Cell Line; Cells; Cessation of life; Code; Complex; crosslink; Data; Data Set; Dicer Enzyme; Down-Regulation; effective therapy; Generations; Genes; Goals; HIV; HIV Infections; HIV-1; Hybrids; immunoregulation; in vivo; Infection; knock-down; Knock-out; Ligation; Mediating; Messenger RNA; MicroRNAs; Mitotic; Molecular; mutant; Necrosis; neuron loss; novel; overexpression; Pathway interactions; Pharmacotherapy; prevent; Production; Proteins; Proviruses; Reactive Oxygen Species; response; RNA; RNA Interference; RNA-Induced Silencing Complex; Route; Seeds; Shock; Site; Small Interfering RNA; Small RNA; Stress; T-Lymphocyte; Testing; Therapeutic; Tissues; Toxic effect; transcriptome sequencing; Untranslated RNA; Viral; virology; Virus; Virus Replication; Work; ","6mer seed toxicity and AIDS","150910","ZRG1","Special Emphasis Panel ","","","01","125000","72500","197500",""
"9967524","U54","MD","3","N","03/23/2020","01/01/2020","04/30/2020","307","U54MD000214","SCHOOLS OF PUBLIC HEALTH","PA-18-906","3U54MD000214-18S1","NIMHD:41666\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","BALTIMORE","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Project Narrative: This project seeks to reduce health disparities by partnering with the Black Church to facilitate the adoption of a dementia education program with dementia caregivers, those with mild dementia, and their family, learn influences of the social cultural environment on dementia caregiving at the interpersonal and community levels.","6374004; ","GASKIN, DARRELL J.;","SAYRE, MICHAEL","09/22/2002","04/30/2022","Address; Adoption; advocacy organizations; African American; Aging; Awareness; Back; base; Belief; Biological; brain health; care burden; Caregiver Burden; caregiver interventions; Caregivers; Caring; Characteristics; Cholesterol; Church; Communities; Community Outreach; Data; Decision Making; Dementia; dementia care; Dementia caregivers; dementia caregiving; Development; Diabetes Mellitus; Diagnosis; Discipline of Nursing; Discrimination; Disease Management; disparity reduction; District of Columbia; Education; education resources; Educational Intervention; Educational Materials; Educational workshop; Environment; ethnic minority population; experience; Face; faith-based intervention; Family; Family Caregiver; family caregiving; Financial Hardship; Focus Groups; Foundations; Friends; Future; Goals; Health; health disparity; Health education; health literacy; Health Services; Healthcare; hearing impairment; Home environment; Hour; Hypertension; Impaired cognition; improved; Individual; informal caregiver; Institution; Institutionalization; Knowledge; Lead; Learning; Life; Life Cycle Stages; Link; literacy; Literature; member; Memory Loss; Mental Depression; Morbidity - disease rate; mortality; Nurses; Outcome; Participant; Population; Preventive measure; programs; psychological distress; Quality of life; racial minority; Recommendation; recruit; Reporting; Research; Resources; Risk Factors; risk minimization; satisfaction; Services; skills; Sleep; social; social stigma; Stress; symposium; Testing; Time; Training; Training and Education; Training Programs; Trust; uptake; Work; ","Development of a Faith-Based intervention in Dementia Caregiving","000214","","","","S1","18","25445","16221","41666",""
"9971329","R01","AI","3","N","03/26/2020","03/26/2020","05/31/2020","855","R01AI127709","SCHOOLS OF MEDICINE","PA-18-906","3R01AI127709-02S1","NIAID:19998\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAN FRANCISCO","UNITED STATES","PATHOLOGY","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","NARRATIVE Autoimmune diseases can lead to chronic and often disabling illnesses, and is a major health problem in the US as it affects millions of Americans. While there are treatments available to help prevent the symptoms of autoimmune disease, there is no cure, and the available treatments do not work for all patients with autoimmune diseases. There is therefore an urgent need for greater understanding of the underlying mechanisms of disease in order to facilitate improved treatments, and perhaps one day ? a cure.","9883060; 10214012 (contact); ","FRIETZE, SETH E; SCHJERVEN, HILDE  (contact);","PEYMAN, JOHN A","06/15/2018","05/31/2023","Affect; Age; American; Antibodies; Antigens; Antinuclear Antibodies; Autoimmune Diseases; Autoimmune Process; Autoimmunity; autoreactive B cell; autoreactivity; B-Cell Activation; B-Cell Development; B-Lymphocytes; Biological Assay; Cell Maturation; cell type; Cells; central tolerance; Chronic; clinically relevant; Data; Defect; Development; Disease; DNA Binding; Ensure; Environmental Risk Factor; Epigenetic Process; epigenetic regulation; Etiology; Exons; Fellowship; Flow Cytometry; gene repression; Genes; Genetic; Genetic Predisposition to Disease; Genetic Transcription; genome wide association study; Grant; Health; Human; Immune; Immune Tolerance; immunoregulation; improved; insight; Investigation; Knowledge; Laboratory Research; Lead; Link; LoxP-flanked allele; Lung; Mature B-Lymphocyte; Mediating; member; Modeling; Molecular; mouse model; Mus; mutant; mutant mouse model; Mutant Strains Mice; Mutate; Mutation; novel; Pathogenesis; Patients; Phenotype; prevent; programs; Protein Isoforms; Proteins; Regulator Genes; Reporting; response; Role; Serum; Signal Transduction; Specificity; Symptoms; System; targeted treatment; Testing; TNFSF5 gene; tool; Training; transcription factor; transcriptomics; United States; Work; Zinc Fingers; ","Studies to understand how mutations in the IKZF1 gene can contribute to development of autoimmune disease","127709","","","","S1","02","12460","7538","19998",""
"9973935","R01","AI","2","N","03/24/2020","03/24/2020","02/28/2021","855","R01AI072648","SCHOOLS OF MEDICINE","PA-19-056","2R01AI072648-11","NIAID:486000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SYRACUSE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","24","058889106","US","5992619","UPSTATE MEDICAL UNIVERSITY","NY","132102306","PROJECT NARRATIVE This project is focused on the pathogenesis of systemic lupus erythematosus (SLE), a chronic autoimmune disease of unknown etiology. The proposed research is relevant to public health as SLE affects 0.1% of the US population, mainly women of child-bearing age, with 10% mortality in 5 to 10 years. There is an unmet medical need as current treatments are only partially effective and carry significant side effects. Development of new therapies has been hampered by gaps in our understanding of pathogenesis. Metabolic pathways that control the production of energy in the form of ATP and generate reactive oxygen intermediates (ROI) have emerged as essential regulators of immune responses and contributors to lupus pathogenesis. Comprehensive metabolome studies indicate that SLE profoundly impacts the utilization of glucose through the pentose phosphate pathway (PPP) eliciting changes that mimic deficiency of a rate-limiting enzyme, transaldolase (TAL). In turn, TAL deficiency elicits activation of the mechanistic target of rapamycin (mTOR), which has been recently identified as a key sensor of oxidative stress and driver of inflammation in SLE. The results of the proposed studies will bring new breakthroughs in our understanding of how metabolic pathways control oxidative stress during development of autoimmunity that can be harnessed for safe and effective treatment of SLE.","1891355; ","PERL, ANDRAS ;","JOHNSON, DAVID R","02/01/2008","02/28/2025","Adaptive Immune System; Address; Affect; Aldehyde Reductase; Anabolism; Antibody Formation; Antiphospholipid Antibodies; Antiphospholipid Syndrome; aryldialkylphosphatase; Arylesterase; Autoantibodies; Autoimmune Diseases; Autoimmunity; base; Biological Response Modifiers; Blood Circulation; Carbon; CD3 Antigens; CD8B1 gene; cell type; Cells; Chronic; chronic autoimmune disease; Citric Acid Cycle; Comorbidity; Complex; congenic; constriction; Development; DNA; effective therapy; Electron Transport; Enzymes; Etiology; Exhibits; Female of child bearing age; FRAP1 gene; Fumarates; gene therapy; Genetic; Glomerulonephritis; Glucose; Glycolysis; glycosylation; Goals; Hepatocyte; Human; Immune response; Immune system; in vivo; Inflammation; Inflammatory; innovation; inorganic phosphate; Interleukin-17; Interleukin-4; Knowledge; Liver; Liver diseases; Longitudinal Studies; Lupus; lupus prone mice; Lymphocyte; Mediating; Medical; Metabolic; Metabolic Control; Metabolic Pathway; Metabolism; metabolome; Mitochondria; Modeling; mortality; Mus; NADH dehydrogenase (ubiquinone); NADP; Nephritis; novel therapeutics; overexpression; Oxidation-Reduction; Oxidative Stress; Pathogenesis; Pathway interactions; Patients; Pentosephosphate Pathway; Pharmacology; Plasma; Population; Production; Proteins; Public Health; reactive oxygen intermediate; Regulation; Regulatory T-Lymphocyte; Research; Resolution; Role; sensor; side effect; Sirolimus; stable isotope; Stable Isotope Labeling; stem; systemic autoimmunity; Systemic Lupus Erythematosus; T memory cell; T-Cell Development; T-Lymphocyte; Testing; Therapeutic; Therapeutic Intervention; Transaldolase; Work; ","Metabolic Control of Systemic Autoimmunity","072648","HAI","Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section ","","","11","300000","186000","486000",""
"9984848","R01","ES","5","N","03/24/2020","03/01/2020","02/28/2021","113","R01ES027544","SCHOOLS OF MEDICINE","RFA-ES-15-020","5R01ES027544-04","NIEHS:393675\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","HOUSTON","UNITED STATES","INTERNAL MEDICINE/MEDICINE","09","051113330","US","481201","BAYLOR COLLEGE OF MEDICINE","TX","770303411","Project Narrative The proposed project will address the gender difference in diabetes development due to exposure to inorganic arsenic. We will examine the role of estrogen and estrogen receptor in the process, and test whether modulating these molecules could protect the body from arsenic toxicity. The project is highly relevant to public health because arsenic and diabetes are widespread environmental hazard or human disease, and recent human studies identified correlation between the two.","10455071; ","SUN, ZHENG ;","SCHUG, THADDEUS","03/01/2017","02/28/2022","Address; Animal Genetics; Animal Model; Arsenic; Binding; Blood; blood glucose regulation; carcinogenesis; Chemicals; Complex; Deacetylase; Development; Diabetes Mellitus; Disease; DNA Methylation; Environmental Hazards; enzyme activity; epidemiology study; epigenome; Estradiol; Estrogen Receptor alpha; Estrogen Receptors; Estrogens; Exposure to; Female; gain of function; Gender; gender difference; Gene Expression; genetic manipulation; Glucose Clamp; Glucose Intolerance; glucose metabolism; glucose tolerance; Hazardous Substances; HDAC3 gene; Hepatic; hepatic gluconeogenesis; Hepatocyte; Histone Deacetylase Inhibitor; Hormones; Human; human disease; insulin signaling; insulin tolerance; knock-down; Knock-in; Knock-in Mouse; Knock-out; Knowledge; Light; Lipids; Liver; male; Measurement; Mediating; Metabolic; Metabolic Diseases; Metabolism; Modeling; Molecular; Mus; Mutation; NCOR1 gene; Non-Insulin-Dependent Diabetes Mellitus; novel; Nuclear; Nuclear Receptors; Ovariectomy; pandemic disease; Postmenopause; Predisposition; Prevention; Process; protective effect; Public Health; Pyruvate; Reporting; Resistance; Role; Running; Selective Estrogen Receptor Modulators; sexual dimorphism; small molecule; Techniques; Testing; Toxic effect; Toxic Environmental Substances; Transcriptional Activation; transcriptome sequencing; transcriptomics; Work; ","Gender-Specific Effects of Arsenic in Diabetes","027544","ZES1","Special Emphasis Panel ","","","04","250000","143675","393675",""
"9986018","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","307","U54MD007590","SCHOOLS OF ARTS AND SCIENCES","RFA-MD-18-012","5U54MD007590-33","NIMHD:2116902\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","ATLANTA","UNITED STATES","BIOLOGY","05","065325177","US","2189101","CLARK ATLANTA UNIVERSITY","GA","303144358","Narrative The incidence of prostate cancer is 1.6 and the mortality rate is ~ 2.5 times higher in African- American men when compared to Caucasian men. The reasons for this increased risk for African-American men could be due to inherent biological differences and/or socio-economic reasons. Combined strategies based on basic biological research and community outreach programs are required to combat this disease in the African-American community. Center for Cancer Research and Therapeutic Development (CCRTD) at Clark Atlanta University focuses on its trilateral mission to conduct basic research in prostate cancer, to train the next generation of scientists in prostate cancer and to provide an educational format for the dissemination and treatment of prostate cancer in the African-American community. This proposal seeks funding for partial support of CCRTD to expand and enhance its current activities.","1878925; ","KHAN, SHAFIQ A;","DAS, RINA","06/01/1997","02/29/2024","advanced disease; Affect; African American; Age; Animal Experimentation; anticancer research; Area; Awareness; base; Basic Science; Behavioral; Biological; biological research; Biological Sciences; Caliber; Cancer Biology; cancer cell; cancer therapy; Caucasians; Cellular biology; certificate program; Chemistry; cohesion; combat; Communities; community based participatory research; Community Outreach; Core Facility; Development; Disease; drug discovery; Early Diagnosis; Early treatment; Education; Educational Activities; Equipment; Faculty; Faculty Recruitment; Funding; Future Generations; graduate student; higher education; Incidence; Information Dissemination; Infrastructure; infrastructure development; Institution; interest; International; Laboratories; Laboratory Research; Malignant neoplasm of prostate; Malignant Neoplasms; member; men; Mentors; Mission; Modernization; Molecular; Molecular and Cellular Biology; Molecular Biology; mortality; NCI Center for Cancer Research; next generation; outreach program; Pilot Projects; Postdoctoral Fellow; Prevention; Privatization; Program Development; program dissemination; programs; prostate cancer progression; Prostate Cancer therapy; racial and ethnic; racial diversity; recruit; Research; Research Activity; research and development; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Risk; Schools; Scientist; socioeconomics; Students; Teacher Professional Development; tenure track; Therapeutic; therapeutic development; Time; Training; Training and Education; undergraduate student; United States National Institutes of Health; Universities; ","Enhancement of Cancer Research at Clark Atlanta University","007590","ZMD1","Special Emphasis Panel ","","","33","1402016","715572","2116902",""
"9995792","R01","AI","9","N","03/23/2020","03/23/2020","02/28/2021","855","R01AI152494","SCHOOLS OF MEDICINE","PA-19-056","9R01AI152494-25","NIAID:421998\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","IOWA CITY","UNITED STATES","PHYSIOLOGY","02","062761671","US","3972901","UNIVERSITY OF IOWA","IA","522421320","Candida glabrata is the second major cause of candidemias owing in part to its ability to develop high level resistance to azole antifungal drugs. This application is focused on analyzing connections between the two major pathways for azole resistance.","6365642; ","MOYE-ROWLEY, W SCOTT;","LOVE, DONA","08/01/1993","02/28/2025","Alleles; Antifungal Agents; Aspergillus fumigatus; ATP-Binding Cassette Transporters; Attenuated; Automobile Driving; Azole resistance; Azoles; Biochemical; Biological Assay; C-terminal; Candida; Candida albicans; Candida glabrata; candidemia; Carrier Proteins; CDR1 gene; Cell membrane; Cell Nucleus; Cells; chromatin immunoprecipitation; Clinic; Complex; Coupled; crosslink; Data; DNA Binding; Drug Efflux; Drug resistance; efflux pump; Enzymes; Epitopes; Ergosterol; Exhibits; Fluconazole; gain of function; gain of function mutation; Gene Activation; Gene Expression; gene induction; Genes; genetic analysis; Genetic Transcription; Goals; Haploidy; High-Throughput Nucleotide Sequencing; Homologous Gene; Infection; insight; intermolecular interaction; Lanosterol; Lead; Link; Maps; Mass Spectrum Analysis; Mediating; Mediator of activation protein; Molecular; mRNA Expression; multi drug transporter; Mutagenesis; mutant; Mutation; Organism; Pathogenicity; Pathway interactions; Pharmaceutical Preparations; Physiological; Polyenes; prevent; Production; Proteins; recruit; Regulation; Resistance; resistance allele; response; Sepsis; Specificity; Sterols; Testing; transcription factor; Transcriptional Activation; Transcriptional Activation Domain; Transcriptional Regulation; transcriptome sequencing; Yeasts; Zinc Cluster; ","Genetic analysis of pleiotropic drug resistance","152494","ZRG1","Special Emphasis Panel ","","","25","276842","145156","421998",""
"10013526","R01","AI","1","N","03/23/2020","03/24/2020","02/28/2021","855","R01AI150502","SCHOOLS OF ARTS AND SCIENCES","PA-19-056","1R01AI150502-01A1","NIAID:746936\NICHD:200000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW YORK","UNITED STATES","PSYCHOLOGY","12","620127915","US","1605019","HUNTER COLLEGE","NY","100655024","Project Narrative Gay, bisexual, and other sexual minority men (SMM), who are at disproportionately high risk for HIV infection, are also less likely to achieve viral load (VL) suppression compared to other groups. Research is needed to identify preventable structural, psychosocial, and behavioral factors that influence VL suppression for the purposes of developing effective early intervention strategies. Moreover, the successful implementation of TasP and U=U messaging is a necessary component of the strategy to end the HIV epidemic, but rigorous research is needed to inform its successful implementation. We aim to address these issues with two studies grounded in the Social Ecological Model (SEM) to simultaneously examine both VL suppression and implementation barriers surrounding U=U from multiple levels of influence. Study 1 will involve longitudinally following 250 newly diagnosed SMM, capitalizing on an existing cohort tracking HIV seroconversion, to examine predictors of durable VL suppression as well as any potential risks associated with implementing U=U. In Study 2, we will use focus groups conducted three times over five years to inform implementation of U=U messaging.","10767419 (contact); 15292330; ","RENDINA, H JONATHON  (contact); TALAN, ALI ;","SHARP, GERALD B","03/24/2020","02/28/2025","Address; Adherence; Advocacy; AIDS prevention; American; antiretroviral therapy; Back; base; Behavioral; Biological; Bisexual; Blood; care providers; Caring; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Trials; cohort; Complement; Consensus; Continuity of Patient Care; Couples; critical period; Data Reporting; design; Diagnosis; Drops; Early Intervention; Empirical Research; Enrollment; Epidemic; Epidemiology; Event; Financial compensation; Focus Groups; Future; Gays; General Population; Goals; Guidelines; Health; Health Personnel; high risk; HIV; HIV diagnosis; HIV Infections; HIV Seronegativity; HIV Seropositivity; Home environment; improved; improved outcome; indexing; Individual; Infection; insight; Intervention; Interview; Lead; Link; Location; men; men who have sex with men; men's group; Methods; Minority; Modeling; Monitor; Morbidity - disease rate; mortality; Movement; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; National Institute of Mental Health; Nature; Newly Diagnosed; Outcome; Patient Self-Report; Pattern; Persons; Phase; Population; Prevention; Provider; psychosocial; Public Health; Qualitative Methods; recruit; Research; resilience; Resistance; Risk; Risk Factors; routine practice; Safety; Sampling; scale up; Sex Behavior; Sexual Health; sexual HIV transmission; sexual minority; social; Spottings; Stress; Structure; Study models; success; surveillance data; Surveys; theories; therapy adherence; therapy development; Time; TimeLine; Translating; transmission process; Treatment Efficacy; United States National Institutes of Health; uptake; Viral; Viral Load result; virtual; ","Understanding Viral Suppression for Newly Diagnosed HIV+ Men to Inform Implementation of TasP and U=U","150502","HIBI","HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section ","","A1","01","625013","321923","946936",""
"10013582","R01","CA","1","N","03/24/2020","03/24/2020","02/28/2021","395","R01CA250851","SCHOOLS OF PUBLIC HEALTH","PAR-18-189","1R01CA250851-01","NCI:679536\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","BALTIMORE","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","NARRATIVE The proposed project will answer key questions to inform the HIV, oncology, and geriatric clinical management of older people living with HIV (PLWH) diagnosed with a non-AIDS defining cancer (NADC). In order to disentangle the influence of HIV from the socio-behavioral factors associated HIV acquisition, we will leverage claims data from more than 5 million Medicaid beneficiaries across 14 states between 2001-2017 which provides an appropriate comparison population for older (i.e., >50 years of age), low income PLWH. Findings from this study will inform how aging in the presence of HIV affects the risk and consequences of non-AIDS defining cancers, and impacts HIV care and age-related outcomes among older adults.","10795436 (contact); 8609959; ","JOSHU, CORINNE E. (contact); LAU, BRYAN ;","DOMINGUEZ, GERALDINA","03/24/2020","02/28/2025","Acquired Immunodeficiency Syndrome; Address; Admission activity; Affect; Age; age related; Age-Years; Aging; aging population; AIDS/HIV problem; antiretroviral therapy; base; beneficiary; Cancer Control; cancer diagnosis; cancer prevention; cancer therapy; cancer type; Caring; Cessation of life; Chemotherapy and/or radiation; Chronic; Clinical Management; cohort; Cohort Studies; Colorectal Cancer; Comorbidity; comparison group; Complement; Continuity of Patient Care; Data; Dementia; demographics; Development; Diagnosis; Elderly; Enrollment; Ethnic Origin; Event; experience; Female; Fracture; General Population; Health Services Accessibility; healthy aging; High Prevalence; high risk; HIV; HIV diagnosis; HIV Infections; Incidence; Infection; Knowledge; Length of Stay; Low income; malignant breast neoplasm; Malignant neoplasm of lung; Malignant neoplasm of prostate; Malignant Neoplasms; Medicaid; Medicare; men; Modernization; mortality; multidisciplinary; Older Population; oncology; Operative Surgical Procedures; Outcome; outcome forecast; Polypharmacy; Population; Population Heterogeneity; Poverty; Prevention strategy; Race; racial difference; Radiation therapy; Resources; Risk; Risk Factors; Sample Size; sex; Sex Differences; Smoking; Social Behavior; Socioeconomic Status; Subgroup; therapy adherence; Time; treatment strategy; Treatment-Related Cancer; Woman; ","Medicaid data as a complement to cohort studies for investigating cancers among older people with HIV","250851","PPAH","Population and Public Health Approaches to HIV/AIDS Study Section ","","","01","414984","264552","679536",""
"10055438","R21","DC","7","N","03/25/2020","09/01/2019","06/30/2020","173","R21DC017227","SCH ALLIED HEALTH PROFESSIONS","PAR-16-057","7R21DC017227-03","NIDCD:156158\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS","","PITTSBURGH","UNITED STATES","OTHER HEALTH PROFESSIONS","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","PROJECT NARRATIVE  Stuttering is a neurodevelopmental disorder with profound consequences for communication and quality of life. This project will take an innovative approach that combines neurophysiological and behavioral data, along with parental report measures, to enhance our understanding of attentional control in the development of stuttering. Project outcomes will lay the foundation for a long-term research program that informs theories and treatment approaches in stuttering by incorporating attentional control processes.","10699998; ","HAMPTON WRAY, AMANDA M;","SHEKIM, LANA O","07/05/2018","06/30/2021","","Attentional control in children who stutter","017227","CDRC","Communication Disorders Review Committee ","","","03","108162","47996","156158",""
"10098632","R21","NS","7","N","03/27/2020","02/06/2020","08/31/2020","853","R21NS099632","","PA-18-590","7R21NS099632-03","NINDS:15592\","Non-SBIR/STTR RPGs","2017","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","PHOENIX","UNITED STATES","","07","131606022","US","2052813","ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER","AZ","850134409","Contact PD/PI: Manfredsson, Fredric P Project Narrative This project is aimed at addressing the novel hypothesis which states that a functional loss of the Parkinson's disease (PD) - associated protein alpha-synuclein (?-syn) is causative in PD. This hypothesis is in stark contrast to the prevailing hypothesis which states that ?-syn aggregates themselves are directly toxic: the basis for a substantial amount of PD therapeutic research. This proposal outlines a set of experiments aimed to characterize the neurodegenerative profile in a new mouse model of ?-syn functional loss; thus providing a foundation for future therapeutic PD research aimed at maintaining ?-syn homeostasis. Project Narrative Page 7","10623256; ","MANFREDSSON, FREDRIC ;","SIEBER, BETH-ANNE","09/30/2016","08/31/2020","","Alpha-synuclein is crucial for neuronal function and survival-Characterization of a novel conditional alpha-synuclein knockout mouse model","099632","CDIN","Cell Death in Neurodegeneration Study Section ","","","03","10060","5532","15592",""
"10102102","OT2","HL","1","N","03/23/2020","03/23/2020","12/31/2020","837","OT2HL155038","","RFA-OT-A1-007","1OT2HL155038-01","NHLBI:409398\","OTHERS","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","HOUSTON","UNITED STATES","","09","051113330","US","481201","BAYLOR COLLEGE OF MEDICINE","TX","770303411","","10643285; ","SHEEHAN, VIVIEN ANDREA;","","03/23/2020","12/31/2020","Allogenic; base; Biological Markers; biomarker performance; Blood; blood rheology; Cellular Morphology; Chimerism; Clinical Trials; CRISPR/Cas technology; Data; Defect; Disease; Engraftment; epidemiology study; Erythrocytes; experience; Fetal Hemoglobin; gene therapy; Gene-Modified; Genes; Genotype; Goals; Hematological Disease; Hematopoietic Stem Cell Transplantation; hemoglobin AA; hydroxyurea; improved; Individual; Laboratories; Measures; Microfluidic Microchips; Modality; Outcome; Patients; Perfusion; Pharmacology; predictive marker; reduce symptoms; Reproducibility; Research; response; Rheology; Running; Sampling; Sensitivity and Specificity; Shipping; Sickle Cell Anemia; Sickle Cell Trait; sickling; Site; Stem cells; Subfamily lentivirinae; Symptoms; Testing; Transfusion; ","Rheology biomarkers for gene-based therapy","155038","ZHL1","Special Emphasis Panel ","","","01","409398","","409398",""
"10130954","P20","GM","5","N","03/24/2020","02/12/2020","06/30/2020","","P20GM109089","","PAR-14-035","5P20GM109089-05","NIGMS:149963\","RESEARCH CENTERS","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","ALBUQUERQUE","UNITED STATES","","01","829868723","US","10021612","UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR","NM","871310001","","14905570; ","HOGEVEEN, JEREMY P;","CALDWELL, SHEILA","","","","Reinforcement Learning Neuropathologies Underlying Psychiatric Sequelae in Traumatic Brain Injury","109089","ZGM1","Special Emphasis Panel ","5240","","05","101785","48178","","149963"
"9841181","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:223500\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE Obesity and diabetes are at epidemic levels, and the toxicity of environmental contaminants during perinatal development could be a significant contributor to these trends. The proposed studies will offer innovative new insights to understanding the role of exercise in mitigating the health impacts of in utero contaminant exposures. Project 2 clearly addresses three of the Superfund Research Program primary objectives: Mandate 1, ?advanced techniques for detection, assessment and evaluation of the effect of hazardous substances on human health?, Mandate 2, ?methods to assess the risks to human health presented by hazardous substances?, and Mandate 4, ?methods to reduce the amount and toxicity of hazardous substances.?","10180341; ","PEARSON, KEVIN JOSEPH;","","","","Acids; Address; adipocyte differentiation; Adipocytes; Adolescent; Adult; Agonist; Aryl Hydrocarbon Receptor; base; Behavior Therapy; Biochemical; biological adaptation to stress; blood glucose regulation; Body Composition; Breast; Cells; Child; cohort; Collaborations; cost effective; dechlorination; Detection; Development; Diabetes Mellitus; diabetes risk; diphenyl; Discipline of Nursing; disorder risk; Endocrine Disruptors; Environmental Exposure; Environmental Impact; Environmental Pollution; Epidemic; Erythroid; Evaluation; Exercise; exercise intervention; Exposure to; Fatty acid glycerol esters; Female; fetal; Funding; Future; Gender; Glucose Clamp; Glucose Intolerance; glucose uptake; Goals; Gold; Hazardous Substances; Health; Home environment; Human; Human Development; impaired glucose tolerance; Impairment; improved; in utero; in vivo; Infant; innovation; insight; Insulin Resistance; insulin sensitivity; insulin signaling; Intervention; Kentucky; Knockout Mice; Life Style; lipid biosynthesis; Liver; male; Measures; Mesenchymal Stem Cells; Metabolic; Methods; Modeling; Molecular; mouse model; Mus; Muscle Cells; Neonatal; neonate; Nuclear; nutrition; Obesity; obesity development; obesity in children; obesity risk; obesogen; offspring; offspring obesity; Outcome; Oxidative Stress; Pathway interactions; perfluorooctanoic acid; Perinatal; perinatal development; Perinatal Exposure; Phenotype; Play; pollutant; Polychlorinated Biphenyls; postnatal; Predisposition; Pregnancy; prenatal exposure; Preventive Intervention; Process; programs; Research; Risk; Role; Running; Sampling; sedentary; Serum; specific biomarkers; Superfund; superfund chemical; Techniques; Testing; Thinness; Time; Tissues; Toxic effect; transcription factor; trend; Umbilical cord structure; Universities; Work; ","Postnatal Complications and Interventions against Halogenated Organics during Pregnancy","007380","ZES1","Special Emphasis Panel ","5741","","22","154138","69362","","223500"
"9844952","R01","HL","5","N","03/22/2020","01/01/2020","12/31/2020","837","R01HL073021","SCHOOLS OF MEDICINE","PA-18-484","5R01HL073021-11","NHLBI:764407\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PHILADELPHIA","UNITED STATES","SURGERY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Ischemic mitral regurgitation (IMR) is a large and growing global public health problem. IMR repair with undersized ring annuloplasty is currently the preferred treatment for IMR. However, 1/3 of all patients treated this way develop significant recurrent IMR. There is now agreement that adjunctive procedures are required. But there is no consensus regarding the best procedure. Many procedures have been proposed. Given the number of proposed procedures clinical studies comparing the efficacy of each would be extremely unwieldy if not impossible to carry out. It is the goal of this proposal to develop novel computational approaches directed towards optimized annuloplasty ring design and leaflet augmentation procedures to help expedite the development of the most efficacious techniques.","1897289 (contact); 1914720; ","GORMAN, ROBERT C (contact); SACKS, MICHAEL S;","SOPKO, GEORGE","01/04/2019","12/31/2022","Affect; Age; Agreement; American; Anatomy; Animal Model; Animals; Anterior; base; Calibration; Cells; Clinical; clinical application; Clinical Research; Clinical Trials; comparative efficacy; Computer Models; Computer software; Consensus; Coronary Artery Bypass; Coupled; Data; Data Reporting; design; Development; Devices; Dilatation - action; Elements; Etiology; Evaluation; Geometry; Goals; hemodynamics; Human; Image; Image Analysis; Image-Guided Surgery; imaging software; in silico; in vitro Model; in vivo; interest; Knowledge; Left Ventricular Function; Left Ventricular Remodeling; Measures; Mechanics; Methodology; Methods; Mitral Valve; Mitral Valve Insufficiency; Modeling; Myocardial Infarction; novel; papillary muscle; Pathogenesis; Pathology; patient subsets; Patients; Phase; Population; Postoperative Period; Procedures; prospective; Public Health; randomized trial; Recurrence; Registries; repaired; Resolution; Retrospective Studies; Secondary to; simulation; Stress; Structure; Structure of chordae tendineae cordis; Techniques; Three-Dimensional Echocardiography; Time; Tissues; tool; translation to humans; Validation; Work; ","Quantitative Methods for Optimizing IMR Repair","073021","ZRG1","Special Emphasis Panel ","","","11","616916","147491","764407",""
"9850639","R34","MH","5","N","03/26/2020","03/05/2020","01/31/2021","242","R34MH112648","","RFA-MH-17-612","5R34MH112648-03","NIMH:159000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","CINCINNATI","UNITED STATES","","01","071284913","US","615001","CINCINNATI CHILDRENS HOSP MED CTR","OH","452293039","PROJECT NARRATIVE Relevance: Medication is an efficacious treatment strategy for adolescents with attention-deficit/hyperactivity disorder (ADHD), however use significantly declines during adolescence when the consequences of ADHD are most severe (e.g. dropping out of school, delinquency, etc.). We expect to produce an optimized intervention that engages the mechanism underlying medication continuity among adolescents with ADHD. Dissemination of an effective intervention platform could markedly improve outcomes for millions of adolescents and thereby has a tremendous potential public health impact.","8934295; ","BRINKMAN, WILLIAM BERNARD;","PINTELLO, DENISE","04/12/2018","01/31/2021","Accounting; Address; Adherence; Adolescence; Adolescent; Attention deficit hyperactivity disorder; Behavior; behavior change; care outcomes; Caring; Child; Chronic; Data; design; Development; effective intervention; Effectiveness; efficacy study; Evidence based intervention; expectation; experience; experimental study; falls; forgetting; Funding; Future; improved; improved outcome; Individual; Intention; Intervention; Mediator of activation protein; medication compliance; Medicine; Modeling; multi-component intervention; Online Systems; Outcome; Parents; pediatrician; Pharmaceutical Preparations; Positioning Attribute; Practice Guidelines; prevent; Problem Solving; Public Health; Randomized Controlled Trials; Research; School Drop-Outs; Shapes; Side; skills; Supervision; System; Testing; Text Messaging; theories; therapy development; Time; treatment strategy; United States National Institutes of Health; usability; ","Improving Medication Continuity among Adolescents with ADHD","112648","ZMH1","Special Emphasis Panel ","","","03","100000","59000","159000",""
"9851389","R01","EY","5","N","03/26/2020","02/01/2020","01/31/2021","867","R01EY027314","SCHOOL OF MEDICINE & DENTISTRY","PA-13-302","5R01EY027314-04","NEI:385646\","Non-SBIR/STTR RPGs","2020","NATIONAL EYE INSTITUTE","","ROCHESTER","UNITED STATES","OPHTHALMOLOGY","25","041294109","US","7047101","UNIVERSITY OF ROCHESTER","NY","146270140","Our goal is to induce, magnify and accelerate vision recovery in cortical blindness (CB) using attention cues during training. The proposed stimulus and trial design will allow us to also characterize processing mechanisms that underlie training-induced plasticity in V1-damaged, adult visual systems. Expected outcomes include a better understanding of the properties and mechanisms that underlie visual recovery in CB. The impact of this project will include improved scientific knowledge, development of new methods to optimally recruit plasticity of the damaged, adult visual system, and improved technical capability and clinical practices for enhancing vision and quality of life for people suffering from CB.","7762327; ","HUXLIN, KRYSTEL R;","WIGGS, CHERI","02/01/2017","01/31/2021","Address; Adult; Affect; Age-Years; Area; area striata; Attention; base; blind; Chronic; Clinical; clinical practice; Communities; Computers; Conscious; Contralateral; Cortical Blindness; Cues; Data; Development; Discrimination; Discrimination Learning; Effectiveness; Ensure; Eye; gaze; Goals; improved; Individual; insight; Knowledge; Learning; Location; Measurable; Methods; Motion; Motor Cortex; Noise; Outcome; Patient Education; patient expectation; patient population; Patients; Performance; Physical therapy; Population; Property; Quality of life; Recovery; recruit; rehabilitation strategy; Rehabilitation therapy; relating to nervous system; Research; Research Personnel; Residual state; response; restoration; selective attention; signal processing; Site; Standardization; Stimulus; Sum; Task Performances; Testing; theories; tool; Training; Treatment outcome; trial design; Vision; Visual; Visual attention; Visual Fields; visual processing; Visual system structure; Width; Work; ","Attention-driven enhancement of visual training in cortical blindness","027314","CP","Cognition and Perception Study Section ","","","04","261640","124006","385646",""
"9853531","P20","GM","1","N","03/24/2020","12/01/2019","11/30/2020","","P20GM130418","","PAR-18-266","1P20GM130418-01A1","NIGMS:493714\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MISSOULA","UNITED STATES","","00","010379790","US","1381006","UNIVERSITY OF MONTANA","MT","598124104","","15276374; ","GRAHAM, JONATHAN ;","","","","Academic Medical Centers; Address; Air; Area; base; Biometry; Child; Child Health; Climate; cluster computing; Computerized Medical Record; computing resources; Consult; Data; data access; data acquisition; Data Analyses; Data Analytics; data centers; data management; data registry; data resource; Data Science; Data Sources; demographics; Development; disease transmission; Electronic Health Record; Environmental Monitoring; Exposure to; fine particles; Fire - disasters; Future; Geography; Health; health data; High Performance Computing; Immunization; improved; Individual; innovation; Laboratories; Manuscripts; Mathematics; Medical Records; Modeling; Montana; Outcome; Particulate Matter; Population; Preparation; Prevention Research; Prevention strategy; Provider; Records; Research; Research Personnel; Research Project Grants; Resolution; Resources; Risk; Rural; Rural Community; Rural Health; rural setting; Science; Smoke; sociodemographics; spatiotemporal; statistics; Structure; Testing; Time; Training; urban area; Vital Statistics; Wildfire; ","Data and Modeling Core","130418","ZGM1","Special Emphasis Panel ","7779","A1","01","368384","125330","","493714"
"9854058","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:258011\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","1884959; ","WEINSTOCK, GEORGE M;","","","","Abbreviations; Address; Archives; Area; Automation; Automobile Driving; base; Binding; Biological Assay; Biology; Cancer Biology; cancer cell; Cancer Center; cancer genome; cancer genomics; cancer therapy; Cells; Cellular biology; Chromatin Structure; Collaborations; community center; Complement; Complex; Computational Science; Core Grant; cost; Cytometry; Data; Data Analyses; data management; Dideoxy Chain Termination DNA Sequencing; Dissociation; DNA; DNA Modification Process; DNA sequencing; Educational workshop; Ensure; Epigenetic Process; epigenome; epigenomics; Experimental Designs; Faculty; Funding; Generations; Genetic; Genome; genome analysis; Genomic Instability; Genomics; Goals; graduate student; Heterogeneity; host neoplasm interaction; Image; improved; Individual; Infrastructure; innovation; intercellular communication; Laboratories; Libraries; liquid biopsy; Malignant Neoplasms; Management Information Systems; meetings; member; Metadata; Methods; Microfluidics; Modification; Molecular; Molecular Biology; Names; NCI Center for Cancer Research; novel sequencing technology; nucleic acid purification; operation; Phenotype; Positioning Attribute; Postdoctoral Fellow; Process; programs; Proteins; Protocols documentation; Regulation; Research; Resistance; Resolution; Resource Sharing; Resources; RNA; Sampling; Scientist; service programs; Services; single cell technology; single molecule; Specificity; structural genomics; Structure; System; Systems Analysis; Technology; technology development; Testing; The Jackson Laboratory; Time; Tissues; tool; Toxic effect; Training; Training and Education; transcriptome; transcriptome sequencing; transcriptomics; tumor; Tumor Biology; tumor DNA; tumor heterogeneity; tumor microenvironment; Variant; whole genome; ","Genome and Single Cell Technologies Shared Resource","034196","NCI","Subcommittee H - Clinical Groups ","7972","","34","148758","109253","","258011"
"9856434","R03","DE","5","N","03/23/2020","02/01/2020","01/31/2021","121","R03DE027108","SCHOOLS OF MEDICINE","PAR-15-344","5R03DE027108-02","NIDCR:149204\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH","","EAST LANSING","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","08","193247145","US","5245901","MICHIGAN STATE UNIVERSITY","MI","488242600","Project Narrative The proposed research will formulate a less restrictive semiparametric model to further our understanding of the life course of early childhood dental caries in relation to important risk factors. The success of the project will advance our knowledge of early childhood caries in low-income African-American children, and help policy makers formulate prevention recommendations targeted for specific subgroups of this population, which ultimately will eliminate intra-group oral health disparities.","8035326; ","TODEM, DAVID ;","RIDDLE, MELISSA","02/01/2019","01/31/2021","Address; African American; Age; Behavior; Behavioral; Biological; Caregivers; Caries prevention; Child; Cities; Clinical; Clinical Research; Communities; Complex; Computer software; Coupled; Data; Dental caries; Development; Disease; DMF Index; early childhood; epidemiology study; evidence base; experience; flexibility; Formulation; Frequencies; Funding; health disparity; Human; improved; indexing; Individual; inner city; Intervention; Investigation; Knowledge; Life; Life Cycle Stages; Link; Literature; longitudinal analysis; Longitudinal Studies; Low Birth Weight Infant; Low income; Measures; Methodology; Methods; Michigan; Modeling; Oral cavity; Oral health; Pathologic Processes; Play; Policies; Policy Maker; Population; Prevalence; Prevention; Primary Dentition; psychologic; Public Health; Recommendation; Research; Research Design; Risk Factors; Role; screening; semiparametric; socioeconomics; Statistical Methods; Structure; Subgroup; success; Surface; Time; Tooth structure; tooth surface; Toothbrushing; United States National Institutes of Health; ","Longitudinal Analysis of Dental Caries Indices in Inner-City African-American Children","027108","ZDE1","Special Emphasis Panel ","","","02","100000","49204","149204",""
"9867659","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:39185\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Address; Advisory Committees; Area; Cancer Center; Cancer Center Support Grant; clinical investigation; Clinical Research Associate; Clinical Trials; Colorado; Development; Doctor of Philosophy; Effectiveness; Ensure; Evaluation; Extramural Activities; Feedback; Funding; Goals; Hematologic Neoplasms; Hormones; Individual; Infrastructure; Laboratories; Leadership; lens; Malignant Neoplasms; Measures; meetings; member; Monitor; NCI Center for Cancer Research; operation; organizational structure; Play; Policies; Population Sciences; Process; programs; Protocols documentation; reconstruction; recruit; Research; Resource Sharing; Role; Series; Site Visit; Strategic Planning; Structure; Sum; System; The University of Colorado Cancer Center; Universities; Vision; Visit; ","Planning and Evaluation","046934","NCI","Subcommittee H - Clinical Groups ","5057","","32","25531","13654","","39185"
"9867665","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:185637\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Agreement; anticancer research; Area; Automobile Driving; Basic Science; Bibliography; Bioinformatics; Budgets; Cancer Center Support Grant; cancer diagnosis; cancer type; Cell Line; cell preparation; Cells; Client; Cloning; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Collection; Colorado; Consultations; CRISPR library; CRISPR/Cas technology; Custom; deep sequencing; design; Development; DNA; Doctor of Philosophy; Education; Equipment; Experimental Designs; Experimental Models; experimental study; Fees; fly; functional genomics; Funding; Future; gain of function; gene function; Gene Pool; Genes; genetic analysis; genetic manipulation; Genetic Screening; genome editing; genome-wide; Genomic DNA; genomic tools; Genomics Shared Resource; Glycerol; Guide RNA; Human; Human Genome Project; Human Resources; improved; Individual; Institutes; interest; Investigation; knock-down; knockout gene; Laboratories; Leadership; Lentivirus Vector; Libraries; Licensing; loss of function; meetings; member; Modification; Mus; new technology; next generation sequencing; novel; novel therapeutics; Open Reading Frames; operation; particle; Pathway interactions; Peer Review; Plasmids; Platyhelminths; Positioning Attribute; Preparation; Prevention; programs; promoter; protein expression; protein function; Protein Overexpression; Protocols documentation; Publications; Reaction; Reagent; Reporting; repository; Research; Resources; response; RNA Interference; RNA library; Services; small hairpin RNA; Source; Suspensions; Technology; Time; tool; Training; Universities; Update; vector; Vertebral column; Viral; web site; webinar; Work; Yeasts; ","Functional Genomics Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5062","","32","119712","65925","","185637"
"9867670","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:161760\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","anticancer research; antitumor agent; Area; Awareness; base; Basic Science; Biophysics; Budgets; Cancer Biology; cancer cell; Cancer Center Support Grant; Cell physiology; Chromatin; Clinic; Colorado; Complement; Consult; Consultations; Core Facility; Cryoelectron Microscopy; Crystallization; Data; Data Analyses; Data Collection; detector; Development; Dimensions; Doctor of Philosophy; Drops; Drug Design; drug discovery; Education; Educational workshop; Ensure; Epigenetic Process; Equipment; experience; Experimental Designs; falls; Fees; Funding; Future; Gene Expression Regulation; Goals; Grant; Human Resources; Hybrids; Image; improved; insight; Institution; instrument; instrumentation; Light; Malignant Neoplasms; Medical; member; Methods; Molecular; Molecular Structure; Molecular Target; NMR Spectroscopy; novel; Optics; Outcomes Research; outreach; Peer Review; Pharmacology; Preparation; Process; Production; programs; protein expression; protein purification; Publications; Research; Research Personnel; Resource Sharing; Resources; robotic system; Roentgen Rays; Sampling; Science; Services; Signal Transduction; Site; solid state nuclear magnetic resonance; Source; Spectrum Analysis; Structural Biochemistry; structural biology; Structure; System; Technology; theories; Time; tool; Training; Translations; tumor progression; United States National Institutes of Health; Universities; Validation; Work; Writing; X-Ray Crystallography; ","Structural Biology Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5067","","32","104357","57403","","161760"
"9867671","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:180516\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Academic Medical Centers; Advanced Malignant Neoplasm; Anatomy; anticancer research; Archives; Area; biobank; Blood specimen; Body Fluids; Budgets; cancer care; Cancer Center; Cancer Center Support Grant; cancer clinical trial; cancer prevention; Chemoprevention; Clinical; Clinical Data; Clinical Research; Clinical Trials; clinically relevant; Collaborations; Collection; Colorado; Computer Assisted; Consent; Consult; Consultations; Core Facility; Custom; Data; Data Sources; data warehouse; design; Detection; Development; Doctor of Philosophy; Education; Ensure; epidemiologic data; Equipment; equipment acquisition; Fees; Formalin; Funding; Future; Goals; Grant; health data; Human; Human body; human tissue; Image; Image Analysis; improved; Individual; Institution; laser capture microdissection; Leadership; Link; Logistics; Longterm Follow-up; Medical; member; Molecular; molecular pathology; Morphology; National Institute of Diabetes and Digestive and Kidney Diseases; oncology; Outcome; Outcome Assessment; Pathologic; Pathology; Patients; Peer Review; Peer Review Grants; Population Sciences; precision medicine; Procedures; Process; professor; programs; prospective; Prostate Cancer Prevention Trial; Protocols documentation; Publications; Quality Control; repository; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Selenium and Vitamin E Efficacy Trial; Services; Southwest Oncology Group; Specimen; Standardization; Students; System; Tissue Microarray; Tissue Sample; Tissues; Translational Research; Universities; ","Tissue Biobanking & Processing Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5068","","32","116419","64097","","180516"
"9867740","R01","MH","5","N","03/24/2020","03/24/2020","02/28/2021","242","R01MH094524","SCHOOLS OF ARTS AND SCIENCES","PA-13-302","5R01MH094524-10","NIMH:629153\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","ATLANTA","UNITED STATES","PSYCHOLOGY","05","837322494","US","676604","GEORGIA STATE UNIVERSITY","GA","303023999","Project Narrative. The recognition that bipolar disorder and schizophrenia are closely linked phenomenologically, physiologically and genetically, rather than clearly separated disorders, leads us to perform a diagnosis-blind three-way analysis of structural neuroimaging, genome-wide scan, and symptom data on an aggregated dataset of over 4000 individuals with diagnoses of bipolar disorder or schizophrenia. We identify the linked patterns of gray matter effects and symptom presentation across diagnostic groups, distinguishing genetic networks and brain patterns underlying the clinically disparate presentations of positive and negative psychotic symptoms.","7117069 (contact); 8825358; ","CALHOUN, VINCE D (contact); TURNER, JESSICA ;","KOESTER, SUSAN E","03/01/2012","02/28/2022","Address; Anhedonia; Arousal; Attention; Auditory; Automobile Driving; base; Behavior; Biological; Bipolar Disorder; bipolar spectrum; blind; Brain; case control; Categories; Clinical; Clinical Data; clinical heterogeneity; Cognitive; Complex; Corpus striatum structure; Data; Data Set; density; Development; Diagnosis; Diagnostic; Dimensions; Disease; epidemiology study; Family; follow-up; Foundations; Fright; Functional disorder; General Population; Genes; Genetic; genetic analysis; Genetic Models; genetic pedigree; genetic profiling; Genome Scan; Genotype; Goals; gray matter; Grouping; Hallucinations; Heritability; Heritable Quantitative Trait; Heterogeneity; Image; Image Analysis; Imaging Techniques; Individual; Inferior; interest; International; Label; Language; language perception; Left; Link; Maps; Measures; Medial; Memory; Mental Processes; Methods; Mining; Modeling; morphometry; Nature; neural circuit; Neurobehavioral Manifestations; Neurobiology; neuroimaging; Paranoia; Parietal; Pathway interactions; Patient Self-Report; Patients; Pattern; Perception; Physiological; Play; Psyche structure; psychiatric symptom; Psychotic Disorders; psychotic symptoms; Quantitative Trait Loci; Research; Research Domain Criteria; response; Rewards; Risk; risk variant; Role; Sampling; Schizophrenia; Self Perception; social; Source; Structure; Subgroup; symptom cluster; Symptoms; Techniques; theories; Time; Update; Variant; vector; Work; ","Mining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia","094524","NPAS","Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section ","","","10","468149","161004","629153",""
"9876961","R01","NS","5","N","03/23/2020","03/01/2020","02/28/2021","853","R01NS110707","SCHOOLS OF MEDICINE","PA-18-484","5R01NS110707-02","NINDS:336875\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","HOUSTON","UNITED STATES","NEUROSURGERY","09","800771594","US","578417","UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON","TX","770305400","Project Narrative Spinal cord injury is a devastating neurological condition which often leaves patients wheelchair bound. No cure has been found so far. Stem cell transplantation is a promising therapy which could replace lost neurons and possibly stimulate regrowth of endogenous tissues. We propose to test stem cells derived from patients? own cells in their potential to improve locomotor function recovery in clinically relevant spinal cord injury animal models.","10660819; ","LIU, YING ;","BAMBRICK, LINDA LOUISE","03/01/2019","02/29/2024","Ablation; Acute; Address; Anatomy; Animal Model; Astrocytes; Axon; axon regeneration; axonal degeneration; axonal sprouting; base; behavior test; Biological Assay; biotinylated dextran amine; Cell Nucleus; Cell Therapy; cell type; Cells; Cervical; Cervical spinal cord injury; Cervical spinal cord structure; Cholera Toxin Protomer B; clinically relevant; Contusions; Corticospinal Tracts; Data; Dorsal; dorsal column; Electron Microscopy; Electrophysiology (science); Food; functional loss; Future; Generations; graft function; gray matter; Horns; Human; Immunoelectron Microscopy; improved; induced pluripotent stem cell; injured; insight; interest; Label; Laceration; Locomotor Recovery; Mediating; Microscopy; Modeling; Molecular; motor recovery; Natural regeneration; nerve stem cell; neural circuit; neural graft; Neurologic; Neurons; neuroprotection; novel therapeutics; Patients; Phase; Phenotype; progenitor; Protocols documentation; Recovery of Function; relating to nervous system; remyelination; Role; Sensory; Somatosensory Evoked Potentials; Spinal Cord Contusions; Spinal cord injury; Spinal Cord Lacerations; Stem cell transplant; Stem cells; Synapses; System; Testing; Therapeutic; Time; Tissues; tool; Transplantation; Vesicular stomatitis Indiana virus; Walking; Wheelchairs; white matter; Work; ","Reconnecting the injured cervical spinal cord by transplanted human iPSC-derived neural progenitors","110707","ANIE","Acute Neural Injury and Epilepsy Study Section ","","","02","218750","118125","336875",""
"9878912","R01","HL","5","N","03/24/2020","01/01/2020","12/31/2020","837","R01HL136407","SCHOOLS OF MEDICINE","PA-16-160","5R01HL136407-03","NHLBI:771585\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LA JOLLA","UNITED STATES","FAMILY MEDICINE","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","PROJECT NARRATIVE Heart failure (HF) affects approximately 6 million Americans, with approximately 650,000 new cases/year, and is associated with high rates of mortality. Although regular physical activity / exercise has been shown to significantly improve exercise tolerance and reduce morbidity and mortality in HF, exercise as a reliable adjunctive intervention remains limited due to extremely poor adherence. This proposed study will examine the effectiveness of the HEART?PLAY exercise intervention led by peer and clinic staff to significantly improve and sustain exercise adherence in HF patients.","1962688; ","MILLS, PAUL J;","COOPER, LAWTON S","01/15/2018","12/31/2022","Accelerometer; Adherence; Adopted; Aerobic; Affect; Age; American; base; behavior change; Biological Markers; California; Cardiac health; Cardiology; Clinic; Clinical; Congestive Heart Failure; Cost Analysis; cost effectiveness; Counseling; Data; design; Diagnosis; disorder later incidence prevention; Education; Educational Materials; Effectiveness; EFRAC; Elderly; Ensure; Environment; ethnic diversity; Event; Exercise; exercise adherence; exercise intervention; exercise program; exercise regimen; Exercise Therapy; Exercise Tolerance; exercise training; Feedback; follow-up; Funding; Galectin 3; Goals; Guidelines; Hand Strength; Health; Health Educators; health training; Healthcare Systems; Heart; Heart failure; Heart Rate; Hospitals; implementation strategy; improved; inclusion criteria; Individual; Infrastructure; interest; Intervention; intervention program; Lead; Leadership; life time cost; markov model; Measures; men; Modeling; Moderate Exercise; Monitor; Moods; Morbidity - disease rate; mortality; Motivation; National Heart, Lung, and Blood Institute; National Institute on Aging; Outcome; Participant; Patients; pedometer; peer; peer support; Physical activity; Physical Function; preservation; programs; Public Health; Quality of life; Randomized Controlled Trials; Regimen; Request for Proposals; Research; Resistance; response; role model; Running; Schedule; sex; Site; sleep quality; social; social cognitive theory; Social support; socioeconomics; Specialist; strength training; successful intervention; Support Groups; Telephone; Testing; tool; Training; Universities; Use Effectiveness; Walking; Woman; Work; ","HL-132: Increasing Adherence to Guideline-Based Exercise Therapy For Chronic Heart Failure","136407","BMIO","Behavioral Medicine, Interventions and Outcomes Study Section ","","","03","497797","273788","771585",""
"9886302","D43","TW","5","N","03/26/2020","03/01/2020","02/28/2021","989","D43TW010913","SCHOOLS OF PUBLIC HEALTH","PAR-17-057","5D43TW010913-03","FIC:246101\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","NEW ORLEANS","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","01","053785812","US","8424601","TULANE UNIVERSITY OF LOUISIANA","LA","701185665","8. Project Narrative Peru is rapidly increasing in stature in public health and tropical disease research, but training grants based in major universities in Lima that support this work have largely bypassed academic institutions in Iquitos, the major infectious disease research center on the Amazon River. This D43 training grant is specifically designed to address and correct this disparity, offering a collaborative research training program in partnership with the Universidad Nacional de la Amazonia Peruana (UNAP). Our goal is to expand the local workforce of highly trained professionals with public health and infectious diseases research skills, which we propose to achieve by forming a collaborative Master?s degree program based at UNAP with both north-south and south-south training components, led by faculty from UNAP, Universidad Peruana Cayetano Heredia [the leading biomedical research university in Peru, located in Lima], Tulane, and Johns Hopkins Universities.","6669192; 1974691 (contact); ","KOSEK, MARGARET N; OBERHELMAN, RICHARD A (contact);","SINA, BARBARA J","04/11/2018","02/28/2023","Address; base; Biomedical Research; Biometry; Bypass; Certification; Cities; Communicable Diseases; Communities; Counseling; Degree program; design; Educational Curriculum; Epidemiology; Faculty; Field Workers; Funding Agency; Future; Goals; Grant; Health education; Health Professional; Infectious Diseases Research; Institution; International; Laboratories; Master's Degree; Mentors; Peru; Peruvian; programs; Public Health; public health research; Research; Research Training; Role; Science; Services; skills; Students; summer institute; technological innovation; Technology; Training; Training Activity; Training Programs; Tropical Disease; Tropical Medicine; Universities; Writing; ","Enabling Infectious Disease Research Capacity in the Peruvian Amazon","010913","ZRG1","Special Emphasis Panel ","","","03","241331","4770","246101",""
"9889131","R25","GM","5","N","03/23/2020","03/01/2020","02/28/2021","859","R25GM104547","","PAR-17-051","5R25GM104547-09","NIGMS:411564\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BRONX","UNITED STATES","","14","081266487","US","10053556","ALBERT EINSTEIN COLLEGE OF MEDICINE","NY","104611900","Project Narrative The goal of this Post-Baccalaureate Research Education Program (PREP) is to provide underrepresented minority and disabled students who want to pursue a career in biomedical research with the intensive research experience and academic enhancement to make them competitive applicants to rigorous PhD and MD-PhD programs. This will expand the diversity of the biomedical research and teaching workforce in the United States as it seeks the best and brightest scientists to improve the health of all Americans.","1859306; ","AKABAS, MYLES H.;","GIBBS, KENNETH D","04/01/2013","02/28/2023","Active Learning; Admission activity; African American; Alaska Native; American; Bachelor's Degree; base; Biomedical Research; career; college; Communication; Communities; County; Creativeness; design; Development Plans; Disabled Persons; disabled students; Doctor of Philosophy; doctoral student; Economically Deprived Population; Economics; education research; Educational process of instructing; Engineering; Enrollment; Ensure; Environment; ethnic diversity; Evaluation; expectation; experience; Faculty; Family; Foundations; Goals; Health; Hispanic Americans; improved; Individual; innovation; Institution; Interdisciplinary Study; Interview; Journals; Knowledge; Laboratory Research; Learning; medical schools; Medicine; Mentors; Minority; minority scientist; National Institute of General Medical Sciences; Native Americans; Native Hawaiian; NIH Program Announcements; novel; Occupations; Oral; Outcome; Pacific Islands; peer; peer coaching; Population; pressure; Process; programs; racial and ethnic; racial diversity; Recording of previous events; Reporting; Research; Research Project Grants; Running; Science; Science, Technology, Engineering and Mathematics; Scientist; skills; social; socioeconomic disadvantage; Solid; statistics; success; support network; System; Training; Training Programs; undergraduate research; undergraduate student; Underrepresented Minority; underrepresented minority student; United States; United States National Institutes of Health; Universities; volunteer; Woman; Work; ","Einstein Postbaccalaureate Research Education Program","104547","TWD","Training and Workforce Development Subcommittee - D ","","","09","381078","30486","411564",""
"9903375","R01","GM","5","N","03/27/2020","03/01/2020","02/28/2021","859","R01GM115342","SCHOOLS OF MEDICINE","PA-18-484","5R01GM115342-06","NIGMS:312257\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","CORAL GABLES","UNITED STATES","BIOCHEMISTRY","27","052780918","US","5221250","UNIVERSITY OF MIAMI SCHOOL OF MEDICINE","FL","331462926","The Nucleolar Detention Center: A Hub of Long Noncoding RNA that Imprison Proteins During Stress Narrative My group has recently discovered a cellular prison used to temporarily detain proteins and RNA. Cells imprison proteins and RNA to survive adverse conditions, such as low oxygen and high temperature. We want to understand how this prison confines proteins and RNA so that we can make our normal cells live when they are exposed to damaging incidents including stroke and heart attack. !","11232879; ","LEE, STEPHEN ;","REDDY, MICHAEL K","07/24/2015","02/28/2023","Amyloid; amyloidogenesis; Architecture; base; Biochemical Pathway; Biological; Biology; Cell Nucleolus; Cells; Cytoplasmic Structures; Data; detention center; Development; Dinucleoside Phosphates; Dinucleotide Repeats; DNA; environmental stressor; Eukaryotic Cell; experimental study; Exposure to; extreme temperature; Family; Funding; Genome; Germ Cells; Grant; granule cell; High temperature of physical object; human disease; Human Genome; Immobilization; Imprisonment; insight; interest; Investigation; Junk DNA; Laboratories; Length; Light; Liquid substance; Malignant Neoplasms; Membrane; Modeling; Molecular; Myocardial Infarction; National Institute of General Medical Sciences; nervous system disorder; Normal Cell; novel; Nuclear; Nuclear Envelope; Organelles; Oxygen; Pathologic; Phase; Physiological; Physiological Processes; Play; Poly(A)+ RNA; Prisons; Process; programs; Property; protein aminoacid sequence; Protein Array; Protein Dynamics; Proteins; Publishing; Radiation; Recovery; recruit; Regulatory Pathway; Repetitive Sequence; Reporting; Research; response; Ribosomes; RNA; RNA, Messenger, Stored; Role; Scientist; Seeds; Solid; Stimulus; Stress; stress granule; stressor; Stroke; System; Testing; Untranslated RNA; Work; ","The Nucleolar Detention Center: a Hub of Long Noncoding RNAs that Imprison Proteins During Stress","115342","NCSD","Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section ","","","06","203425","108832","312257",""
"9905410","U01","HL","5","N","03/26/2020","03/01/2020","02/28/2021","838","U01HL135842","SCHOOLS OF MEDICINE","PAR-15-085","5U01HL135842-04","NHLBI:532263\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","ANN ARBOR","UNITED STATES","SURGERY","12","073133571","US","1506502","UNIVERSITY OF MICHIGAN AT ANN ARBOR","MI","481091276","PROJECT NARRATIVE Pulmonary hypertension (PH) is a complex disorder associated with elevated pulmonary arterial pressure. Unlike in systemic hypertension, for which patients have effective pharmacological management of blood pressure for decades, PH prognosis remains poor with 15% mortality within 1 year on modern therapy. Animal models and invasive clinical assessment have yielded limited insight into disease progression. We submit that there is a pressing need to develop a multi-scale (MS) computational model that can couple the short term (e.g. hemodynamics) and long-term tissue growth & remodeling interactions between the RV and the pulmonary circulation in PH subjects.","9240273; 9961543; 11309245 (contact); ","BAEK, SEUNGIK ; DORFMAN, ADAM LEE; FIGUEROA, CARLOS ALBERTO (contact);","NATARAJAN, ARUNA R","03/15/2017","02/28/2021","Anatomy; Animal Model; Assimilations; base; Bayesian Analysis; Biological Markers; Biomechanics; Blood Circulation; blood pressure regulation; Blood Vessels; Calibration; Cardiac; Cardiac Catheterization Procedures; Cardiopulmonary; cardiopulmonary system; Cardiovascular system; Cessation of life; Child; Childhood; Chronic; Clinical; Clinical assessments; Clinical Data; Clinical Research; Complex; computer framework; Computer Models; Coronary artery; Coupled; Coupling; Data; Diagnosis; diagnosis standard; Disease; Disease Progression; dosage; Early Diagnosis; Engineering; Etiology; Evolution; Failure; follow-up; Goals; Gold; Growth; Heart; Heart failure; heart function; Heart Transplantation; hemodynamics; Human; hypertension control; Hypoxia; Image; Individual; insight; Intervention; Intravenous; Kinetics; Lead; Lung; Magnetic Resonance Imaging; Measurement; Mechanics; Medication Management; Methods; Microcirculation; Modeling; Modernization; Monitor; mortality; multi-scale modeling; Operative Surgical Procedures; Oral; Organ; Outcome; outcome forecast; palliative; patient population; Patients; Pediatric cohort; Peripheral; Pharmacology; Physical Examination; Physics; pressure; Prevalence; primary pulmonary hypertension; prospective; Pulmonary artery structure; Pulmonary Circulation; Pulmonary Hypertension; Pulmonary Vascular Resistance; Right ventricular structure; simulation; Statistical Methods; Statistical Models; Structure; Study models; System; Systemic hypertension; Techniques; Time; treatment strategy; Uncertainty; Vasodilator Agents; Ventricular; Ventricular Septal Defects; Work; ","Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension","135842","ZEB1","Special Emphasis Panel ","","","04","425217","107046","532263",""
"9913988","F32","HD","5","N","03/27/2020","03/01/2020","02/28/2021","865","F32HD095597","SCHOOLS OF MEDICINE","PA-18-670","5F32HD095597-02","NICHD:65310\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","STANFORD","UNITED STATES","PSYCHIATRY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943052004","PROJECT NARRATIVE. Loss of sexual desire causes great personal distress, exacerbates mental illness, and drives patient noncompliance when induced by treatment side effects. Development of effective treatments to alleviate hypoactive sexual desire is hampered by an incomplete understanding of the neural substrates of sexual motivation. The present proposal will provide basic insight into how arousal systems interact with and support sexual motivation.","15079103; ","JENNINGS, KIMBERLY J;","RAVINDRANATH, NEELAKANTA","03/01/2019","10/31/2022","Address; Animals; Antidepressive Agents; Antipsychotic Agents; anxiety-like behavior; Arousal; Automobile Driving; Behavior; Behavioral; Calcium; Cardiovascular Diseases; cell type; Comorbidity; Data; Development; Distress; effective therapy; Electroencephalography; Environment; Etiology; Exposure to; Female; Fiber; Functional disorder; Goals; Gonadal Hormones; Gonadal Steroid Hormones; Hormonal; hormone regulation; Hormones; hypocretin; Hypothalamic structure; Impairment; Infusion procedures; insight; Institution; Interpersonal Relations; Investigation; Lateral; Lateral Hypothalamic Area; Libido; Literature; male; Medial; Mediating; Mental disorders; Metabolic Diseases; Methodology; Mood Disorders; Mood stabilizers; Motivation; Mus; nerve supply; nervous system disorder; neural correlate; Neurobiology; Neuroendocrinology; Neurons; Neuropeptides; Neurosecretory Systems; optogenetics; Partner in relationship; Patient Noncompliance; Patients; Pattern; Personal Satisfaction; Photometry; Physiological; Population; Population Dynamics; Preoptic Areas; Psyche structure; Psychiatric therapeutic procedure; Public Health; Quality of life; Regulation; relating to nervous system; Reporting; reproductive; Reproductive Behavior; Research Personnel; response; Rewards; Risk; Role; self esteem; Sex Behavior; Sexual Dysfunction; skills; social; Social Behavior; Social Interaction; Stimulus; System; Technology; Testing; Training; Treatment Side Effects; Tweens; Universities; Vertebrates; Work; ","Hypothalamic regulation of animal reproductive behavior","095597","ZRG1","Special Emphasis Panel ","","","02","65310","","65310",""
"9940235","D43","TW","1","N","03/25/2020","03/15/2020","12/31/2020","989","D43TW011240","","PAR-19-243","1D43TW011240-01A1","FIC:253834\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","DURBAN","SOUTH AFRICA","","","637360244","SF","5622101","UNIVERSITY OF KWAZULU-NATAL","","3630","The South African Research Ethics Training Initiative (SARETI) is the oldest and most established Africa-based Masters program in the field of health research ethics. The new SARETI PhD program equips African research ethics scholars with advanced theoretical, applied and leadership skills to improve health research systems in Africa, improve effectiveness and efficiency of ethics review systems, and maximize the social value of research in Africa through research ethics leadership and scholarship. Intensive on-site training and home-based research work, including attendance of the Johns Hopkins Intensive Global Bioethics Program, will be facilitated by our experienced local and international multidisciplinary faculty.","10551720; 7963109 (contact); ","KRUGER, MARIANA ; WASSENAAR, DOUGLAS R (contact);","SINA, BARBARA J","03/15/2020","12/31/2025","Achievement; Adult; Africa; African; Area; base; Bioethics; career development; Certification; cohort; Data Analyses; Doctor of Philosophy; Education; Educational workshop; Effectiveness; Ethical Issues; Ethicists; Ethics; experience; Faculty; Funding; Generations; Grant; Health; Home environment; improved; Institutional Review Boards; interest; International; Lead; Leadership; Master's Degree; Mentors; Mentorship; Mission; multidisciplinary; multimodality; Process; programs; Publications; Research; Research Ethics; Research Methodology; Research Proposals; Running; Scholarship; Selection Criteria; Site; skills; Social Values; South African; Structure; Supervision; symposium; System; systems research; Training; United States National Institutes of Health; Universities; Visit; Writing; ","South African Research Ethics Training Initiative (SARETI) Leadership Program","011240","ZRG1","Special Emphasis Panel ","","A1","01","235948","17886","253834",""
"9956715","UG1","DA","5","N","03/25/2020","03/01/2020","02/28/2021","279","UG1DA049467","SCHOOLS OF MEDICINE","RFA-DA-19-008","5UG1DA049467-02","NIDA:422584\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","CHICAGO","UNITED STATES","PSYCHIATRY","07","068610245","US","6644301","RUSH UNIVERSITY MEDICAL CENTER","IL","606123833","Project Narrative This application will establish the Great Lakes Node of the Drug Abuse Clinical Trials Network. The creation of this node will help facilitate research on substance and opioid misuse which are key components of NIH and federal government strategy to reduce the mortality and morbidity associated with the current opioid and substance epidemics. This node will support clinical trials relevant to the epidemics and also advance research in novel models of care, data analytics, mobile interventions and training.","8626029; ","KARNIK, NIRANJAN ;","DOBBINS, RONALD","06/15/2019","02/29/2024","Academic Medical Centers; addiction; Adolescent; adolescent health; African American; Aging; Area; Artificial Intelligence; Asians; base; Buprenorphine; Caring; Cessation of life; Chicago; Cities; Clinical Trials; Clinical Trials Network; Collaborations; collaborative care; Communities; cooking; County; Data Analytics; digital; Distance Education; Drug abuse; eHealth; Electronic Health Record; Emergency department visit; Epidemic; ethnic diversity; experience; Federal Government; Gender Identity; Geography; Health; health disparity; Health system; Heroin; Home environment; Homelessness; Hospitals; Illinois; Indiana; Individual; interest; Intervention; Latino; Learning; Life Cycle Stages; Los Angeles; medical schools; Mentorship; Methods; metropolitan; mHealth; Midwestern United States; Minority; mobile computing; Modeling; Morbidity - disease rate; mortality; National Institute of Drug Abuse; Native Americans; Natural Language Processing; New York; novel; Opioid; Opioid Analgesics; opioid misuse; opioid overdose; opioid treatment program; overdose death; Pacific Island Americans; Pathway interactions; Population; population health; Prevention strategy; Professional Education; Professional Practice; programs; Protocols documentation; Public Health; racial and ethnic; racial diversity; Refugees; Research; Research Methodology; Research Personnel; Research Training; Rest; Rural; rural area; screening; Sex Orientation; sexual identity; Side; socioeconomics; substance misuse; suburb; success; System; telehealth; Testing; Training; Training Support; United States National Institutes of Health; Universities; urban area; Veterans; Vulnerable Populations; waiver; Wisconsin; Work; young adult; ","Great Lakes Node of the Drug Abuse Clinical Trials Network","049467","ZDA1","Special Emphasis Panel ","","","02","285763","136821","422584",""
"9987743","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007582","","RFA-MD-18-012","5U54MD007582-35","NIMHD:317644\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","TALLAHASSEE","UNITED STATES","","05","623751831","US","513802","FLORIDA AGRICULTURAL AND MECHANICAL UNIV","FL","323073105","","1862149; ","SACHDEVA, MANDIP SINGH;","","","","3-Dimensional; Address; Adriamycin PFS; African American; anaphase-promoting complex; Angiotensin Receptor; anti-cancer; Antineoplastic Agents; Apoptosis; Attenuated; base; BAY 54-9085; Binding; Bioavailable; Biological Assay; BRAF gene; Breast; Cancer Biology; cancer cell; Cancer Cell Growth; Cancer cell line; Cancer Etiology; Cancer Patient; cancer therapy; CASP8 gene; cell growth; cell motility; Cells; Cessation of life; Chemosensitization; chemotherapy; Chronic; Clinical Trials; crizotinib; cytotoxic; cytotoxicity; Data; design; Disadvantaged; docetaxel; Dose; Down-Regulation; Drug Kinetics; E-Cadherin; Effectiveness; Endothelial Growth Factors Receptor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor; Epiregulin; Erlotinib; Etoposide; Evaluation; experimental study; Fibroblast Growth Factor Receptors; Fibrosis; Formulation; Future; Gatekeeping; Gefitinib; Generations; Goals; Growth; health disparity; High Pressure Liquid Chromatography; improved; improved outcome; In Vitro; in vivo; indexing; inhibitor/antagonist; knock-down; Laboratories; Lead; Legal patent; Losartan; Lung; Lung Neoplasms; lung xenograft; Malignant neoplasm of lung; MAPK8 gene; Mediating; medulloblastoma; MET gene; migration; mimetics; Minority; Modeling; Mus; mutant; Mutation; nanoparticle; NF1 gene; Non-Small-Cell Lung Carcinoma; novel; Nude Mice; Oral; outcome forecast; p38 Mitogen Activated Protein Kinase; Particle Size; Pathway interactions; Patients; Permeability; Pharmaceutical Preparations; pharmacokinetics and pharmacodynamics; Phosphotransferases; PIK3CA gene; Platelet-Derived Growth Factor Receptor; Population; PPAR gamma; prevent; programs; Protein Tyrosine Kinase; Protocols documentation; Publishing; Research; Research Project Grants; Resistance; response; Rodent; Role; Signal Transduction; small molecule inhibitor; Sprague-Dawley Rats; Stem cells; success; Survival Rate; Sutent; targeted agent; targeted treatment; telmisartan; Therapeutic; Therapeutic Agents; therapy development; Time; Toxic effect; Transforming Growth Factor beta; Treatment outcome; tumor; Tumor Burden; Tumor Stem Cells; Tyrosine Kinase Inhibitor; ubiquitin-protein ligase; Vascular Endothelial Growth Factors; Vimentin; water solubility; Work; Xenograft Model; Xenograft procedure; ","Research Project 2","007582","ZMD1","Special Emphasis Panel ","8130","","35","214624","103020","","317644"
"10046681","UG1","EY","7","N","03/24/2020","03/01/2020","06/30/2020","867","UG1EY020522","SCHOOLS OF MEDICINE","PA-18-590","7UG1EY020522-11","NEI:715679\","OTHER RESEARCH-RELATED","2019","NATIONAL EYE INSTITUTE","","Aurora","UNITED STATES","OPHTHALMOLOGY","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","PROJECT NARRATIVE With 12 years of National Eye Institute support, the US Satellite of Cochrane Eyes and Vision (CEV@US) has guided production of priority systematic reviews of comparative effectiveness research (CER); these reviews inform decisions about vision care and lead to preserved sight and prevention of blindness. We will partner with individual and organizational stakeholders to build a workforce in CER by providing educational opportunities, to identify evidence gaps, to support evidence-based guidelines, and to disseminate our findings.","10498318; ","LI, TIANJING ;","BHARGAVA, SANGEETA","05/01/2010","06/30/2022","Academic Medical Centers; Achievement; Address; Blindness; care delivery; Caring; Clinical; clinical practice; Clinical Practice Guideline; Collaborations; Communities; comparative effectiveness; compare effectiveness; design; Development; Diagnosis; E-learning; Education; Educational workshop; effectiveness research; Ensure; Equilibrium; evidence base; evidence based guidelines; Evidence based intervention; experience; Eye; flexibility; Foundations; Funding; Generations; Goals; Guidelines; Health; Health Professional; health training; Healthcare; improved; Individual; Influentials; innovation; Institute of Medicine (U.S.); International; Intervention; Journals; Knowledge; Lead; Leadership; Learning; Link; Manuals; massive open online courses; Medical center; medical specialties; meetings; Meta-Analysis; Methodology; Methods; Modeling; Monitor; National Eye Institute; Ophthalmologist; Optometrist; organizational structure; Outcome; Patients; Persons; Policy Maker; Positioning Attribute; preservation; prevent; Prevention; Printed Media; Procedures; Production; Professional Organizations; programs; Publications; Publishing; Recommendation; Research; Research Methodology; Research Personnel; research study; Risk; Role; Slide; social media; Societies; Students; success; symposium; systematic review; Time; United States; Update; Vision; vision science; Visual impairment; Work; ","Comparative Effectiveness Research & Cochrane Eyes and Vision (CEV)","020522","ZEY1","Special Emphasis Panel ","","","11","621550","94129","715679",""
"10075623","R44","AI","4","N","03/24/2020","03/25/2020","02/28/2021","855","R44AI136273","","PA-17-302","4R44AI136273-03","NIAID:962825\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LEBANON","UNITED STATES","","02","828763263","US","10020536","CELDARA MEDICAL, LLC","NH","037661441","PROJECT NARRATIVE Filoviruses, including ebolaviruses and Marburg virus, cause a rapidly progressing and fatal hemorrhagic fever and as demonstrated in the 2013-2016 West Africa epidemic, have the potential to cause widespread disease. Currently, there are no therapeutic strategies on market to mitigate Sudan virus (SUDV), one of the five types of ebolavirus that poses a highly lethal risk to communities, aid workers and civilian populations in the event of a pandemic. We are developing CM-SV1, a first-in-class single dose monoclonal antibody that can be used both as a therapeutic and a prophylactic treatment in the unfortunate event of a SUDV outbreak.","1888855; ","GUYRE, PAUL ;","BEISEL, CHRISTOPHER E","02/16/2018","02/28/2023","Africa; Amino Acid Sequence; animal rule; Animals; Antibodies; Antibody Therapy; base; biodefense; Case Fatality Rates; Categories; Cavia; cell bank; Cessation of life; Chinese Hamster Ovary Cell; Clinical; clinical efficacy; commercialization; Communities; comparative efficacy; Complementarity Determining Regions; Cyclic GMP; Democratic Republic of the Congo; Development; Disease Outbreaks; Dose; Drug Compounding; Drug Kinetics; Ebola Hemorrhagic Fever; Ebola virus; efficacy study; Emergency Situation; Engineering; Epidemic; Event; Family; Fill-It; Filovirus; Frankfurt-Marburg Syndrome Virus; global health emergency; Glycoproteins; Gold; Government; Half-Life; Human; Immunoglobulin G; Immunotherapeutic agent; improved; in vivo; Industry Standard; Infection; Interferon-alpha; Investigational Drugs; Investigational New Drug Application; Knockout Mice; Letters; Life; manufacturability; Medical Staff; meetings; Modality; Modeling; Monoclonal Antibodies; Monoclonal Antibody Therapy; Mus; Nature; neglected tropical diseases; nonhuman primate; novel; pandemic disease; pathogen; Persons; Phase; phase 2 study; Population; preclinical development; Preparation; prevent; Prevention; Production; programs; Property; prophylactic; Prophylactic treatment; Readiness; Research; Risk; RNA Viruses; Safety; Savings; Standard Model; success; Sudan Ebola virus; Technology; Therapeutic; Therapeutic Agents; therapeutic development; therapeutic evaluation; Tobacco; Toxic effect; Uganda; United States Food and Drug Administration; Vaccines; Viral Hemorrhagic Fevers; Virulent; Virus; Virus Diseases; Western Africa; Widespread Disease; Zaire Ebola virus; ","Development of CM-SV1, a monoclonal antibody treatment for Sudan Virus","136273","ZRG1","Special Emphasis Panel ","","","03","","","962825",""
"10102523","R01","HD","7","N","03/27/2020","11/01/2019","07/31/2020","865","R01HD093598","SCHOOLS OF MEDICINE","PA-18-590","7R01HD093598-03","NICHD:408246\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","STANFORD","UNITED STATES","PSYCHIATRY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943052004","PROJECT NARRATIVE This project seeks to improve the effectiveness of a novel dissonance-based obesity prevention program that has reduced future BMI gain and overweight/obesity onset by (a) experimentally testing whether implementing it in single- versus mixed-sex groups, which should increase dissonance-induction that contributes to weight gain prevention effects, and (b) experimentally testing whether adding food response and attention training, which theoretically reduces valuation of and attention for high-calorie foods, increases weight gain prevention effects. This randomized trial would be the first to experimentally manipulate these two factors in an effort to produce superior weight gain prevention effects. A brief effective obesity prevention program that can be easily, inexpensively, and broadly implemented to late adolescents at risk for excess weight gain, as has been the case with another dissonance-based prevention program, could markedly reduce the prevalence of obesity and associated morbidity and mortality.","1890634; ","STICE, ERIC M;","ESPOSITO, LAYLA E","11/01/2019","07/31/2023","","Enhancing Effectiveness of a Dissonance-Based Obesity Prevention Program","093598","CHHD","Biobehavioral and Behavioral Sciences Subcommittee ","","","03","354667","53579","408246",""
"10128593","UM1","HG","5","N","03/24/2020","12/01/2017","11/30/2018","","UM1HG008898","","RFA-HG-15-001","5UM1HG008898-03","NHGRI:522206\","Non-SBIR/STTR RPGs","2018","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","HOUSTON","UNITED STATES","","09","051113330","US","481201","BAYLOR COLLEGE OF MEDICINE","TX","770303411","","1898145; ","GIBBS, RICHARD A;","FELSENFELD, ADAM","","","","ConProject-001","008898","ZHG1","Special Emphasis Panel ","5074","","03","356627","165579","","522206"
"10132036","U10","EY","3","N","03/26/2020","08/01/2018","03/31/2020","867","U10EY022881","","PA-18-590","3U10EY022881-06S1","NEI:129730\","OTHER RESEARCH-RELATED","2020","NATIONAL EYE INSTITUTE","","MEMPHIS","UNITED STATES","","09","941884009","US","578302","UNIVERSITY OF TENNESSEE HEALTH SCI CTR","TN","381034903","PUBLIC HEALTH RELEVANCE: Dry eye disease (DED), one of the most common eye conditions, has significant impact on the quality of life and work place productivity, with an average economic burden estimated at $55 billion/year in the USA. The high prevalence, cost of DED, and graying of the population contribute to its growing public health significance. This project will determine if Omega3 is a more efficacious and cost-effective alternative for DED and provide new information for developing future treatments.","1864722; ","ASBELL, PENNY ;","REDFORD, MARYANN","09/30/2013","03/31/2020","Address; age related; Anti-inflammatory; Area; Artificial Tears; Behavior; Biological Markers; capsule; Caring; Characteristics; Chronic; chronic pain; Clinical; Clinical Data; Clinical Research; Clinical Trials; cost; cost effective; Cyclosporine; Data; Dietary Supplementation; Disease; Economic Burden; effective therapy; Effectiveness; Evaluation; evidence base; Eye; Eye diseases; eye dryness; Fatigue; fatty acid supplementation; Fatty Acids; Future; Health Expenditures; High Prevalence; improved; Inflammation; Inflammatory; Knowledge; Level of Evidence; Long-Term Effects; Masks; Medical Care Costs; ocular surface; Omega-3 Fatty Acids; Ophthalmologist; overtreatment; Pathogenesis; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Physicians; placebo group; Placebos; Polyunsaturated Fatty Acids; Population; pre-clinical research; Prevalence; Productivity; productivity loss; Public Health; public health relevance; Quality of life; Randomized; Randomized Clinical Trials; Safety; Signs and Symptoms; Sjogren's Syndrome; Steroids; Supplementation; Symptoms; Testing; Time; Treatment Efficacy; Vision; Visual; Withdrawal; Workplace; ","Dry Eye Evaluation and Management (DREAM)","022881","ZEY1","Special Emphasis Panel ","","S1","06","85348","44382","129730",""
"9775971","R43","NR","1","N","03/27/2020","03/27/2020","02/28/2021","361","R43NR018622","","PA-18-573","1R43NR018622-01","NINR:219569\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","HUNTSVILLE","UNITED STATES","","05","080423571","US","10051975","GRATEPIC, INC.","AL","358066014","PROJECT NARRATIVE Research suggests that gratitude offers a wide range of physical and psychological benefits. The goal of the GratePic mHealth application is to help users become more grateful and realize many of the associated benefits discovered in previous research projects. The purpose of this project is to test the effectiveness of GratePic. An app with the proven capability to enhance gratitude has the potential to make a significant positive impact on society.","15679879; ","ARRINGTON, CHRISTOPHER LAWSON;","BOUGH, KRISTOPHER J","03/27/2020","02/28/2021","Affect; Amaze; Behavior; blood pressure reduction; Clinical; commercialization; Control Groups; depressive symptoms; design; Development; Effectiveness; Emotions; Empirical Research; Environment; Evaluation; evidence base; Exercise; Fatigue; Feasibility Studies; Feeling suicidal; Focus Groups; Fostering; Goals; gratitude; Image; immune function; improved; Individual; Intervention; iterative design; Journals; Length; Life; Mobile Health Application; Multimedia; Outcome; Participant; Personal Satisfaction; Physiological; Process; psychologic; Psychologist; psychosocial; Randomized; Recovery; recruit; reduce symptoms; Research; Research Project Grants; Research Support; response; social; Social Behavior; Social Network; social relationships; Societies; Techniques; Technology; technology development; Testing; Text; usability; Well in self; Writing; ","GratePic mHealth App Feasibility Study","018622","ZRG1","Special Emphasis Panel ","","","01","","","219569",""
"9839693","R01","NS","5","N","03/25/2020","02/01/2020","01/31/2021","853","R01NS078168","BIOMED ENGR/COL ENGR/ENGR STA","PAS-18-483","5R01NS078168-07","NINDS:347331\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","UNIVERSITY PARK","UNITED STATES","ENGINEERING (ALL TYPES)","12","003403953","US","1524202","PENNSYLVANIA STATE UNIVERSITY-UNIV PARK","PA","168027000","Project Narrative: Cerebral blood flow is controlled by local neural activity and global neuromodulatory state. This proposal will determine how neural activity and neuromodulation combine to generate changes in hemodynamic signals and oxygenation, allowing a more accurate interpretation of hemodynamic signals. 1","10746454; ","DREW, PATRICK JAMES;","BABCOCK, DEBRA J","03/01/2013","01/31/2024","Adrenergic Antagonists; Affect; alertness; Anesthesia procedures; Area; Attention; awake; Behavior; Behavioral; Blood; Blood flow; Blood Vessels; Blood Volume; Brain; brain health; cell type; cerebral hemodynamics; Cerebrovascular Circulation; Coupling; designer receptors exclusively activated by designer drugs; Electrodes; Electrophysiology (science); experimental study; frontal lobe; Functional Magnetic Resonance Imaging; Goals; hemodynamics; Human; Image; Infusion procedures; inward rectifier potassium channel; Light; Locomotion; Masks; Measures; Metabolism; Microelectrodes; Microscopy; Modeling; Molecular; mouse model; Mus; Muscimol; Names; neuroimaging; Neuromodulator; Neurons; neuroregulation; neurovascular coupling; Nitric Oxide Synthase; noradrenergic; Norepinephrine; optical imaging; Optics; Oxygen; Pharmacology; Polarography; Process; recruit; relating to nervous system; response; Role; Signal Transduction; somatosensory; Somatosensory Cortex; Testing; tissue oxygenation; two photon microscopy; two-photon; vasoconstriction; Vasodilation; ","Dissecting the roles of neuromodulation and neural activity in neurovascular coupling during behavior","078168","SPC","Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section ","","","07","218750","128581","347331",""
"9841176","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:152399\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE Exposure to environmental chemicals increases the risk of many non-communicable human diseases. The UK- SRC serves our stakeholders and the broader objectives of the Superfund Research Program by conducting studies to understand mechanisms linking exposure to environmental chemicals with human disease risk, lifestyle based approaches to mitigate these risks and strategies for improved sensing and remediation of toxic environmental chemicals. This core component provides UK-SRC investigators with measurements of these environmental chemicals, their metabolites and degradation products and other biological molecules of relevance to human health.","1879477; ","MORRIS, ANDREW J;","","","","Address; Amendment; Analytical Chemistry; analytical method; base; Basic Science; Biological; Biological Markers; Biological Monitoring; Biological Process; Businesses; Cardiovascular Diseases; cardiovascular disorder risk; Chemicals; Clinical; Clinical Management; clinical translation; Cohort Studies; Collaborations; Communities; computerized data processing; Consent; Coupled; Data Analyses; Data Analytics; data management; Data Reporting; Data Science; Data Storage and Retrieval; Detection; Development; Diet and Nutrition; Disease; disorder risk; Doctor of Philosophy; Ecology; Ensure; environmental chemical; environmental chemical exposure; Environmental Engineering technology; Environmental Exposure; Environmental Health; environmental intervention; Environmental Pollutants; Equipment; Evaluation; Exercise; experience; Exposure to; Funding; Gas Chromatography; Gas-Liquid Chromatography; Goals; Grant; Health; health administration; High Pressure Liquid Chromatography; Human; human disease; Human Resources; improved; In Vitro; Institutional Review Boards; instrument; instrumentation; interest; Intervention; Investigation; Laboratories; laboratory facility; Lead; Life Style; Link; Liquid Chromatography; Literature; Malignant Neoplasms; Management Information Systems; mass spectrometer; Mass Spectrum Analysis; Measurement; Medical center; metabolomics; Methods; National Institute of Environmental Health Sciences; nutrition; offspring; operation; Outcome; pollutant; population health; Pre-Clinical Model; preclinical study; Preparation; Procedures; programs; Protocols documentation; Publications; quality assurance; Quality Control; ranpirnase; Reaction; remediation; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resolution; Risk; Role; Sampling; Schedule; Service provision; Services; Soil; Source; stressor; Superfund; superfund chemical; Support System; System; Technology; Testing; Toxic effect; Toxic Environmental Substances; United States National Institutes of Health; Veterans; Vulnerable Populations; Water; water sampling; Work; ","Biomonitoring and Environmental Analytical Chemistry Core","007380","ZES1","Special Emphasis Panel ","5736","","22","105103","47296","","152399"
"9844415","F30","MH","5","N","03/24/2020","03/01/2020","02/28/2021","242","F30MH118804","SCHOOLS OF MEDICINE","PA-18-668","5F30MH118804-02","NIMH:45861\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","HOUSTON","UNITED STATES","NEUROSCIENCES","09","051113330","US","481201","BAYLOR COLLEGE OF MEDICINE","TX","770303411","Project Narrative The proposed research is relevant to public health because it seeks to understand the control of cortical activity, a central feature of numerous neuropsychiatric disorders. While most current therapies for such diseases target the neuromodulatory systems, our proposed research seeks to target overall cortical activity by manipulating GABAergic interneurons, providing a potential alternative approach to treatment. This project is applicable to the NIH?s mission because it will provide fundamental knowledge about the molecular mechanisms regulating cortical activity and the potential therapeutic applications of these mechanisms in disease.","12384455; ","BRADY, COLLEEN MICHELLE;","PINARD, COURTNEY","03/01/2019","06/30/2022","Address; autism spectrum disorder; base; cell type; Cells; Cerebral cortex; Data; Disease; Electroencephalography; Electrophysiology (science); Enterobacteria phage P1 Cre recombinase; Family; Family member; Frequencies; Functional disorder; Future; Genetic; genetic manipulation; Goals; Image; in vivo; Individual; inhibitory neuron; Inhibitory Synapse; insight; Interneurons; Knock-out; Knowledge; Lead; Maintenance; Mediating; member; Mission; Molecular; mouse model; Mutation; neuroligin 2; neuropsychiatric disorder; neuropsychiatric symptom; neuroregulation; new therapeutic target; novel strategies; optogenetics; Output; Pathogenesis; Pharmacology; Physiology; Play; postsynaptic; presynaptic; Probability; Protein Family; Proteins; Public Health; Pyramidal Cells; recombinase; Regulation; Research; Role; Schizophrenia; Shapes; Slice; Somatostatin; spatiotemporal; Symptoms; Synapses; synaptic inhibition; Synaptic Membranes; System; targeted treatment; Testing; Therapeutic; United States National Institutes of Health; Vasoactive Intestinal Peptide; Viral; virus genetics; ","The role of Neuroligin 2 in the regulation of GABAergic interneuron activity and cortical inhibition","118804","ZRG1","Special Emphasis Panel ","","","02","45861","","45861",""
"9846211","R01","EY","5","N","03/25/2020","01/01/2020","12/31/2020","867","R01EY019743","SCHOOLS OF MEDICINE","PA-13-302","5R01EY019743-10","NEI:381250\","Non-SBIR/STTR RPGs","2020","NATIONAL EYE INSTITUTE","","SALT LAKE CITY","UNITED STATES","OPHTHALMOLOGY","02","009095365","US","514002","UNIVERSITY OF UTAH","UT","841128930","NARRATIVE Normal brain function depends on the orderly development of circuits in the cerebral cortex and on their intact function. Knowledge of the normal circuitry provides a foundation for understanding the causes of impaired brain function and developing corrective measures. Our studies of the normal circuitry between early visual cortical areas will provide greater insight into the causes and effects of central vision defects when these circuits are damaged by stroke or other neurological or developmental cause. In addition, our studies of the normal organization of long-range circuits between visual cortical areas will provide a foundation for understanding the consequences of their dysfunction in disorders of brain function such as autism and schizophrenia, which have been directly linked to abnormalities in inter-areal connectivity (Belmonte et al., 2004, Lynall et al., 2010).","6987105; ","ANGELUCCI, ALESSANDRA ;","FLANDERS, MARTHA C","08/01/2009","12/31/2020","Address; anatomical tracing; Anatomy; Area; area V1; area V2; autism spectrum disorder; Axon; base; Brain; Brain Diseases; cell type; Cells; Cerebral cortex; Complex; Conflict (Psychology); cytochrome c oxidase; Data; Defect; density; design; Development; Dorsal; Electrodes; extrastriate visual cortex; Foundations; Frequencies; Functional disorder; Funding; Goals; Impairment; Injections; insight; Interneurons; Knowledge; Label; Learning; Link; Maps; Measures; Methodology; Modeling; Morphology; neural circuit; Neurologic; Neurons; novel; object recognition; optical imaging; Optics; optogenetics; Output; parallel processing; Pathway interactions; Pattern; Population; presynaptic; Primates; Process; Property; receptive field; Resolution; response; Retina; Retinal; Schizophrenia; segregation; Signal Transduction; Sorting - Cell Movement; Source; Specificity; Stains; Stimulus; Stream; Stroke; Study models; System; Technology; Testing; theories; Thick; Thinness; Tracer; Utah; V1 neuron; Viral; Viral Vector; virtual; Vision; Visual; Visual Cortex; visual information; visual process; visual processing; Visual system structure; Work; ","Parallel pathways in visual cortex: functional connectivity of output pathways from area V1 to area V2","019743","ZRG1","Special Emphasis Panel ","","","10","250000","131250","381250",""
"9853530","P20","GM","1","N","03/24/2020","12/01/2019","11/30/2020","","P20GM130418","","PAR-18-266","1P20GM130418-01A1","NIGMS:677044\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MISSOULA","UNITED STATES","","00","010379790","US","1381006","UNIVERSITY OF MONTANA","MT","598124104","","8320633; ","NOONAN, CURTIS WILLIAM;","","","","Academic Medical Centers; Administrator; Advisory Committees; Applications Grants; Award; Benchmarking; career; career development; Child; Child Health; Collaborations; Communication; Data; design; Development; Development Plans; Ensure; epidemiological model; Evaluation; experience; Extramural Activities; Faculty; formative assessment; Fostering; Funding; Future; Goals; graduate student; Grant; Growth; Health; improved; Individual; Infrastructure; innovation; Intervention; Intervention Studies; Leadership; leadership development; Marketing; Mentors; Mentorship; Modeling; Modification; Montana; Newsletter; outreach; Pathway interactions; Pilot Projects; Prevention Research; Process; Productivity; programs; Recommendation; Recording of previous events; recruit; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Rural; Rural Community; skills; Structure; success; Talents; Teacher Professional Development; Testing; Training; Update; Vision; web site; Work; Writing; ","Admin Core","130418","ZGM1","Special Emphasis Panel ","7778","A1","01","466927","210117","","677044"
"9854060","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:258595\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","1864042; ","SUNDBERG, JOHN PAUL;","","","","Abbreviations; Aging; Anatomy; animal tissue; Autopsy; base; Biochemical; Biological Models; Biometry; Blood Chemical Analysis; Budgets; Cancer Center; Cancer Model; Capital; Capital Financing; Cell surface; Cells; Characteristics; Chemicals; Chemistry; Clinical assessments; Collection; Consultations; Core Grant; cost; Custom; Data; Educational workshop; Electron Microscopy; Ensure; Equipment; experience; Experimental Designs; Flow Cytometry; Fresh Tissue; Funding; Genetic; Genomics; Goals; Health Services Accessibility; Hematology; Histology; Histopathology; Image; Individual; innovation; Institution; instrument; instrumentation; Laboratories; Learning; Link; Mass Spectrum Analysis; member; Microscopy; Modernization; Mus; Names; NON Mouse; peer; Phenotype; Physiological; Price; Process; programs; Protein Analysis; Protein Chemistry; Proteins; Quality Control; Research Project Grants; Resolution; Resource Sharing; Resources; Sampling; Science; Services; Site; skills; Structure; success; symposium; Technology; Time; tissue/cell preparation; Tissues; tool; Training; Training and Education; tumor; whole animal imaging; Work; ","Phenotyping Technologies Shared Resource","034196","NCI","Subcommittee H - Clinical Groups ","7974","","34","149095","109500","","258595"
"9854062","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:409247\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","8683998; ","LIU, EDISON TAK-BUN;","","","","Abbreviations; Acute Myelocytic Leukemia; Award; base; Basic Science; Cancer Center; cancer genome; cancer genomics; Cancer Model; Chronic Lymphocytic Leukemia; Clinical; Core Grant; Data; Development; Direct Costs; Epithelial; Epithelial ovarian cancer; Faculty; Fostering; Funding; Future; Genomics; Goals; Grant; Growth; Hematopoietic stem cells; Human; Human Genetics; human genomics; Immunooncology; in silico; in vivo; innovation; Institution; interdisciplinary collaboration; Laboratories; Leadership; Malignant Neoplasms; member; Mentors; Mesenchymal; Modeling; Mus; Names; novel; Pilot Projects; precision oncology; Productivity; professor; programs; Publications; recruit; Request for Applications; Research; Research Personnel; Resource Sharing; Science; Secure; Seeds; Services; Shapes; Source; System; Systems Biology; technological innovation; The Jackson Laboratory; tool; tumor microenvironment; Validation; Work; ","Developmental Funds","034196","NCI","Subcommittee H - Clinical Groups ","7976","","34","235955","173292","","409247"
"9867661","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:175300\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Advanced Malignant Neoplasm; anatomic imaging; angiogenesis; animal imaging; Animal Model; Animals; anticancer research; Applications Grants; Area; base; Biological Markers; Bioluminescence; Budgets; Cancer Biology; Cancer Center Support Grant; cancer clinical trial; cancer imaging; cancer immunotherapy; Cancer Model; Cellularity; Clinical Sciences; Clinical Trials; Collaborations; Colorado; Consultations; contrast enhanced; Contrast Media; cost effective; cost effectiveness; Data Reporting; Development; Developmental Therapeutics Program; Diffusion Magnetic Resonance Imaging; Doctor of Philosophy; Education; Educational workshop; Emission-Computed Tomography; Equipment; Faculty; Faculty Workshop; Fees; Fluorescence; Fostering; FPS-FES Oncogene; Funding; Future; Grant; Half-Life; Human; human imaging; IACUC; Image; Image Analysis; image guided; image processing; imager; imaging software; Imaging technology; improved; innovation; Institutes; instrumentation; iron oxide nanoparticle; Leadership; magnetic field; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mediation; Medical; medical schools; member; Mentorship; Metabolic; metabolic imaging; Metabolism; metabolomics; microPET; Molecular Probes; mouse model; Multimodal Imaging; Mus; nanoparticle; Nanotechnology; NMR Spectroscopy; novel; optical imaging; Optics; Patients; Peer Review; Pharmacy Schools; Phase I Clinical Trials; Physics; Physiology; Play; Positron-Emission Tomography; postpartum breast cancer; pre-clinical; pregnancy-associated breast cancer; Preparation; programs; Protocols documentation; Publications; quantitative imaging; Radiochemistry; Radioisotopes; Radiology Specialty; Reporting; Research; Research Design; Research Personnel; Resolution; Resource Sharing; Roentgen Rays; Role; Schedule; Science; Secure; Services; single photon emission computed tomography; Students; Technology; Time; Tomography, Computed, Scanners; Training; Training and Education; Translating; Translational Research; Translations; treatment response; tumor; United States National Institutes of Health; Universities; Update; Validation; Visualization; web page; X-Ray Computed Tomography; Xenograft procedure; ","Animal Imaging Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5059","","32","113064","62236","","175300"
"9867663","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:291101\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","aldehyde dehydrogenases; anticancer research; Apoptosis; Awareness; Basic Science; Biological Assay; Budgets; cancer cell; Cancer Center Support Grant; Cancer Grant Supplements (P30); Cancer Research Project; cancer stem cell; Catchment Area; CD44 gene; cell analyzer; Cell Count; Cell Cycle; Cell Membrane Permeability; Cell Proliferation; Cell Separation; Cell Survival; Cells; Clinical; Collaborations; Color; Colorado; Complex; Computer software; Consult; Consultations; cost; cost effective; cytokine; Data; Data Analyses; design; Detection; Development; DNA; Education; Educational workshop; Emerging Technologies; Ensure; Equipment; experience; experimental study; Faculty; Fees; Flow Cytometry; Flow Cytometry Shared Resource; Fluorescent Probes; Funding; Future; Hour; Individual; Institution; instrument; instrumentation; Ions; Knowledge; Laboratories; Lasers; Leadership; Malignant Neoplasms; Manuscripts; member; Methods; Microspheres; National Institute of Arthritis and Musculoskeletal and Skin Diseases; novel; Peer Review; Pharmacotherapy; Phenotype; Play; Population; Positioning Attribute; Post-Translational Protein Processing; Preparation; Price; Procedures; programs; Protein Analysis; protein expression; Protocols documentation; Publications; Quality Control; repaired; Reproducibility; Research; Research Personnel; Resource Sharing; Resources; RNA; Role; Sampling; Science; Services; Signal Transduction; Speed; Stains; Stem cells; System; Techniques; Technology; tool; Training; tumor; Universities; Work; ","Flow Cytometry Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5061","","32","187534","103567","","291101"
"9867668","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:119227\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","analytical method; Animals; anticancer research; ATP-Binding Cassette Transporters; base; Biochemical; Biological; Biological Assay; Biopsy; Budgets; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Model; cancer prevention; Carrier Proteins; Clinical Research; Clinical Trials; Collection; Colorado; Consultations; Data; Data Analytics; design; Detection; Development; Developmental Therapeutics Program; Doctor of Philosophy; Dose; drug development; drug discovery; Drug Exposure; Drug Kinetics; drug mechanism; drug metabolism; Education; efficacy study; Enzyme-Linked Immunosorbent Assay; Enzymes; Equipment; experience; experimental study; Fees; first-in-human; Funding; Future; Goals; Grant; Guidelines; Head and Neck Cancer; High Pressure Liquid Chromatography; improved; In Vitro; in vivo; International; Lead; Letters; liquid chromatography mass spectrometry; Liquid substance; Malignant neoplasm of lung; mathematical analysis; Measures; Medication Management; member; Metabolism; Methods; Modeling; molecular oncology; novel drug combination; novel therapeutics; Patients; Peer Review; Pharmaceutical Preparations; pharmacodynamic biomarker; pharmacodynamic model; pharmacokinetic model; pharmacokinetics and pharmacodynamics; Pharmacology; Pharmacology Shared Resource; Pharmacology Study; Phase; phase 1 study; Physiological; Population; population based; pre-clinical; preclinical development; preclinical study; Procedures; Process Measure; programs; Proteins; Proteomics; Publications; quality assurance; Quality Control; Recording of previous events; Research Design; Research Personnel; response; Rodent Model; Sampling; Secure; Service delivery model; Services; Specimen; System; tandem mass spectrometry; Technology; The University of Colorado Cancer Center; Time; Tissues; Translational Research; tumor; Universities; Validation; Xenobiotics; ","Pharmacology Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5065","","32","110128","9099","","119227"
"9867669","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:218900\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Address; Advocate; Antibodies; anticancer research; Apoptosis; Area; Baculovirus Expression System; base; Basic Science; Biocompatible Materials; bioimaging; Biological; Biological Process; Biological Sciences; Biomedical Research; Budgets; Cancer Biology; cancer cell; Cancer cell line; Cancer Center Support Grant; cancer therapy; Cell Culture Techniques; Cell Line; cell motility; Cell Proliferation; Cells; Cellular biology; Cetuximab; Chemotaxis; Collection; Colorado; Communities; Consult; Consultations; Cultured Cells; Custom; Data; Development; Doctor of Philosophy; Education; Ensure; Epitopes; Equipment; established cell line; Fees; Funding; Future; Gene Expression; Generations; Genes; Guidelines; Hand; Human; humanized antibody; hybridoma production; Hybridomas; Immunodeficient Mouse; In Vitro; in vivo; Institution; instrument; Intellectual Property; interest; International; Investigation; Journals; live cell imaging; Logistics; Malignant Neoplasms; member; Methods; migration; Molecular; Monoclonal Antibodies; monoclonal antibody production; Mus; neoplastic cell; Oncogenes; Peer Review; Pertuzumab; Policies; preclinical study; Price; Process; Production; programs; Property Rights; Proteins; Publications; Reagent; real-time images; Recombinant Proteins; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Services; Signal Pathway; structural biology; System; Technology; Therapeutic Uses; Time; Tissue Culture Shared Resource; tool; translational cancer research; Translational Research; Trastuzumab; tumor; Tumor Cell Line; United States National Institutes of Health; Universities; ","Protein Production / Monoclonal Antibody / Tissue Culture Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5066","","32","141103","77797","","218900"
"9867673","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:136664\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Administrator; Allogenic; Area; base; Cancer Center; Cancer Center Support Grant; cancer clinical trial; Clinical Investigator; Clinical Research; Clinical Trials; Colorado; Committee Members; Cytomegalovirus Infections; data centers; Discipline; Disease; Engineering; Ensure; Evaluation; Grant; Hematologic Neoplasms; Industry; Institutional Review Boards; Intervention; Intervention Studies; Intervention Trial; Letters; Medicine; member; mid-career faculty; Monitor; NCI Center for Cancer Research; Peer Review; programs; Protocols documentation; Research Personnel; research study; Review Committee; Safety; Scientific Evaluation; Site; Stem cell transplant; System; The University of Colorado Cancer Center; Time; Universities; ","Protocol Review & Monitoring System","046934","NCI","Subcommittee H - Clinical Groups ","5070","","32","88218","48446","","136664"
"9867758","R01","NS","5","N","03/25/2020","02/01/2020","01/31/2021","853","R01NS103873","SCHOOLS OF ARTS AND SCIENCES","PA-18-484","5R01NS103873-02","NIA:359460\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","PHILADELPHIA","UNITED STATES","CHEMISTRY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","The aggregation of proteins into neurotoxic oligomers (clusters) and ultimately into fibrillar tangles plays a pivotal role in the progression of Alzheimer's Disease, Parkinson's Disease, and related dementias. The proposed research will study the structures of these protein aggregates to gain insight into the mechanism of their aggregation and the propagation of pathology from cell-to-cell, as well as the ways in which candidate diagnostic and therapeutic molecules interact with the proteins.","7895724; ","PETERSSON, ERNEST JAMES;","MCGAVERN, LINDA","02/15/2019","01/31/2023","abeta accumulation; Adopted; alpha synuclein; Alzheimer's Disease; Amino Acids; Amyloid beta-Protein; Amyloid Fibrils; base; Binding; Cells; Chemicals; Complex; Computer Models; crosslink; Cryoelectron Microscopy; cytotoxicity; Data; Dementia; design; Development; Diagnostic; Disease; Early Diagnosis; Exhibits; experimental study; Fluorescence; Funding; Genetic Polymorphism; Image; imaging agent; in silico; in vitro Assay; inhibitor/antagonist; insight; Invaded; Investigation; Label; Lewy Body Dementia; Measurement; Memory; Methods; Modeling; Modification; Molecular; Molecular Conformation; molecular modeling; Molecular Structure; Monitor; monomer; Multiple System Atrophy; Nerve Degeneration; Nervous system structure; Neurodegenerative Disorders; Neurofibrillary Tangles; Neurons; neurotoxic; novel; Parkinson Disease; Parkinson's Dementia; Pathologic; Pathology; Pathway interactions; Patients; Peptides; Pharmaceutical Preparations; Play; Polymorph; predictive test; preservation; prevent; Principal Component Analysis; Process; protein aggregate; protein aggregation; Protein Dynamics; protein misfolding; protein protein interaction; protein structure; Proteins; Publishing; recruit; Reporting; Research; Resistance; Role; screening; Seeds; small molecule; solid state nuclear magnetic resonance; Structural Protein; Structure; synthetic protein; tau aggregation; tau Proteins; Techniques; Testing; Therapeutic; tool; unnatural amino acids; uptake; ","Studying Aggregation in Neurodegenerative Disease Using Synthetic Proteins","103873","ZRG1","Special Emphasis Panel ","","","02","250000","109460","359460",""
"9872206","R01","MH","5","N","03/26/2020","03/01/2020","02/28/2021","242","R01MH107515","SCHOOLS OF MEDICINE","PA-13-302","5R01MH107515-05","NIMH:434241\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","SAINT LOUIS","UNITED STATES","GENETICS","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","PUBLIC HEALTH RELEVANCE    Williams-Beuren Syndrome is a multisystem disorder, caused by loss of a set of 28 genes, which includes an unusual cognitive profile of increased social drive and profound visual spatial deficits. Duplications of the same genes cause autism. This project aims 1) to discover whether the loss of the three of these genes, the Gtf2i family of transcription factors, might be responsible for this cognitive profile and to 2) discover the molecular and neuroanatomical circuit abnormalities that mediate the alterations in behavior. A better understanding of circuits controlling social behavior is important for identifying new targets for treatment.","6370147; ","DOUGHERTY, JOSEPH D;","ARGUELLO, ALEXANDER","05/06/2016","02/28/2021","7q11.23; Address; analog; Anatomy; autism spectrum disorder; Behavior; Behavioral; Blood; Brain; Cardiac; Chromosomes; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 7; Cognitive; Disease; dosage; Dose; Face; falls; Family; Family member; FKBP10 gene; Gene Expression; Genes; genetic approach; genome editing; GTF2I gene; Heart Diseases; Human; Hypercalcemia; Individual; innovation; interest; Language; Language Delays; Language Development; Mammals; Mediating; Mental Retardation; Molecular; Mus; mutant; Mutant Strains Mice; Mutation; Neurocognitive; Neuropeptides; novel; Oxytocin; Pair Bond; Personality; Phenotype; Plasma; Protein Family; public health relevance; Recurrence; Regulation; response; Role; Separation Anxiety; Series; Signal Pathway; Signal Transduction; social; Social Behavior; social deficits; social engagement; Social Interaction; Statistical Data Interpretation; Stimulus; Symptoms; Synteny; Testing; transcription factor; Transcription Factor 3; transcriptome sequencing; Visuospatial; Williams Syndrome; ","REGULATION OF MAMMALIAN SOCIAL BEHAVIOR BY THE GTF2I FAMILY OF PROTEINS","107515","GHD","Genetics of Health and Disease Study Section ","","","05","284748","149493","434241",""
"9873985","U01","HL","5","N","03/25/2020","02/01/2020","01/31/2021","837","U01HL130204","SCHOOLS OF MEDICINE","PAR-13-128","5U01HL130204-05","NHLBI:402735\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","MADISON","UNITED STATES","BIOSTATISTICS & OTHER MATH SCI","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","PUBLIC HEALTH RELEVANCE: Influenza infection is known to be associated with increased risk of cardiovascular events, and leads to significant morbidity and mortality each year. Annual influenza vaccination is recommended by the Centers for Disease Control and Prevention, but the optimal vaccine regimen that portends the most protection in patients with high risk cardiovascular disease is unclear. The INVESTED study is a multi-center, randomized, active- control clinical trial of high dose influenza vaccine compared to standard dose influenza vaccine for three seasons in adult individuals with a history of myocardial infarction or heart failure who are at high risk for cardiovascular events. The primary outcome is time to first occurrence of death or cardiopulmonary hospitalization, and key secondary outcomes include time to occurrence of the cardiopulmonary death or cardiopulmonary hospitalizations, time to occurrence of all-cause death or all-cause hospitalizations, time to occurrence of all-cause death or cardiovascular hospitalizations, cardiopulmonary death, and all-cause death. The association between geometric mean antibody titers with the risk for death or cardiopulmonary hospitalizations will also be investigated. The results of this trial have the potential to inform health care policy regarding optimal influenza vaccination for individuals with high risk cardiovascular disease, which may in turn reduce morbidity from this annual threat to health stability in patients with cardiovascular conditions. (End of Abstract)","1965840; ","KIM, KYUNGMANN ;","COOPER, LAWTON S","02/15/2016","01/31/2021","Achievement; active control; Acute; acute coronary syndrome; Acute myocardial infarction; Adult; adverse event risk; Age; American; American Heart Association; Antibodies; Antibody Response; Antibody titer measurement; Antibody-mediated protection; Biological Assay; Cardiac; Cardiology; Cardiopulmonary; Cardiovascular Diseases; cardiovascular disorder risk; cardiovascular risk factor; Cardiovascular system; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chest; Chronic; Clinical Trials; college; control trial; Data; Data Coordinating Center; Dose; Double-Blind Method; Elderly; Electronic Health Record; Event; FDA approved; Gold; Health; Health Care Costs; Health Policy; Heart failure; Hemagglutination; high risk; Hospitalization; human old age (65+); Immune response; Individual; Influenza; Influenza A Virus, H1N1 Subtype; Influenza vaccination; influenza virus vaccine; Laboratories; Medical; Meta-Analysis; Methods; Morbidity - disease rate; mortality; mortality risk; Myocardial Infarction; North America; Outcome; Outcome Measure; Outcome Study; Participant; Patients; Pilot Projects; Population; primary endpoint; primary outcome; Protocols documentation; public health relevance; Randomized; randomized trial; Recording of previous events; Regimen; Reporting; Research; Risk; Seasons; secondary outcome; seroconversion; standard measure; Telephone; Testing; Time; trivalent influenza vaccine; Vaccination; vaccination strategy; Vaccine Antigen; vaccine efficacy; vaccine-induced immunity; Vaccines; ","INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated heart failure (INVESTED)-Data Coordinating Center","130204","ZHL1","Special Emphasis Panel ","","","05","294185","108550","402735",""
"9876959","K23","HL","5","N","03/24/2020","03/01/2020","02/28/2021","837","K23HL136657","SCHOOLS OF ARTS AND SCIENCES","PA-16-198","5K23HL136657-04","NHLBI:157132\","OTHER RESEARCH-RELATED","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","GLASSBORO","UNITED STATES","PSYCHOLOGY","01","139203145","US","3873001","ROWAN UNIVERSITY","NJ","080281700","Project Narrative Midlife women are at unique risk for cardiovascular disease, in part due to physical inactivity, and innovative approaches are needed to promote activity in this group. Existing mobile health tools do not target midlife women's distinct physical activity determinants in real time, and rarely are developed or evaluated with input from behavioral scientists. Training in real-time physical activity assessment and optimization of mobile interventions for this group will prepare the candidate to be a leading patient-oriented researcher in physical activity promotion for cardiovascular risk reduction among midlife women.","11815766; ","ARIGO, DANIELLE R;","BOYINGTON, JOSEPHINE","03/01/2018","02/28/2023","Accelerometer; Address; Adult; Adverse event; Age; apprenticeship; Attention; base; Behavioral; Behavioral Research; Behavioral Sciences; Biological; Cardiovascular Diseases; cardiovascular disorder risk; Cardiovascular Physiology; cardiovascular risk factor; Cardiovascular system; Data; design; disorder risk; Effectiveness; Environment; Evaluation; Event; evidence base; experience; Female; gender difference; Goals; group intervention; Health Expenditures; Hour; Human; improved; Individual; innovation; Intervention; Light Exercise; Manuscripts; men; Menopause; Mentored Patient-Oriented Research Career Development Award; mHealth; middle age; mobile application; Moods; mortality; multidisciplinary; National Heart, Lung, and Blood Institute; negative mood; novel; Obesity; Overweight; Participant; Patient Care; patient oriented; Patient Self-Report; Patients; peer; Peer Review; Physical activity; Physical assessment; physical inactivity; Physiology; post intervention; Primary Health Care; Primary Prevention; programs; Psychology; psychosocial; recruit; Reporting; Research; Research Design; Research Personnel; Resources; Risk; Risk Marker; Risk Reduction; Safety; satisfaction; Scientific Advances and Accomplishments; Scientist; skills; smartphone Application; social; Statistical Methods; statistics; Strategic Planning; Symptoms; Testing; therapy development; Time; tool; Training; Training Programs; trait; Translating; Translations; Woman; Women's Health; ","Identifying and Targeting Unique Physical Activity Determinants for Midlife Women","136657","MPOR","NHLBI Mentored Patient-Oriented Research Review Committee ","","","04","145493","11639","157132",""
"9880284","R21","CA","5","N","03/26/2020","03/01/2020","02/28/2021","396","R21CA223887","SCHOOLS OF ARTS AND SCIENCES","RFA-CA-17-010","5R21CA223887-03","NCI:184890\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","MADISON","UNITED STATES","CHEMISTRY","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","Project Narrative The proposed research will make possible the identification and quantification of intact proteoforms in clinically relevant cancer tissue samples. This will both open a new realm of potential cancer biomarkers for early cancer detection and provide critical new information on the precise molecular forms of proteins present in cancer tissues. This information is essential to understanding, and eventually treating, cancer.","1866109; ","SMITH, LLOYD M;","KNOWLTON, JOHN R","03/14/2018","02/28/2021","Address; Amino Acids; base; Cancer Biology; cancer biomarkers; Categories; Cell Culture Techniques; Cells; Chemistry; clinically relevant; Complex; Complex Mixtures; Cysteine; design; Human; Isotope Labeling; Isotopes; Knowledge; Laboratories; Light; liquid chromatography mass spectrometry; Lysine; Malignant Neoplasms; Measurement; Molecular; Motivation; Neutrons; Normal tissue morphology; novel; novel strategies; Pathway interactions; PC3 cell line; Peptide Hydrolases; Peptides; Process; professor; Prostate; Prostatic Neoplasms; protein complex; Proteins; Proteomics; Reaction; Reagent; Research; Resolution; Sampling; Screening for cancer; Specificity; Stable Isotope Labeling; success; Technology; Testing; Tissue Sample; Tissues; Trypsin; Variant; Work; Yeasts; ","Novel NeuCode Tagging Reagents for Identification and Quantification of Intact Proteoforms in Cancer Tissues","223887","ZCA1","Special Emphasis Panel ","","","03","125000","59890","184890",""
"9881346","R01","MH","5","N","03/26/2020","03/01/2020","02/28/2021","242","R01MH112788","SCHOOLS OF MEDICINE","PA-16-160","5R01MH112788-03","NIMH:490408\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","ATLANTA","UNITED STATES","PSYCHIATRY","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","Narrative Genetic variation in the oxytocin receptor gene is associated with variation in social cognition and psychiatric disorders such as autism spectrum disorders. The mechanisms by which variation in the oxytocin receptor gene influence brain function are unknown. This proposal uses the prairie vole model to understand how variation in the oxytocin receptor gene leads to an alteration in brain function, which may inform treatment strategies and a precision medicine approach for autism and other psychiatric disorders.","1879792; ","YOUNG, LARRY J;","ARGUELLO, ALEXANDER","05/24/2018","02/28/2023","Affect; Alleles; Animal Model; Area; Attention; autism spectrum disorder; Behavior; Behavioral; Behavioral Genetics; Binding; Biological; Brain; brain behavior; Brain region; brain tissue; Cell Nucleus; ChIP-seq; Chromatin; chromatin immunoprecipitation; Chromatin Structure; Cognition Disorders; CRISPR/Cas technology; Cues; Data; density; Detection; Diagnosis; disorder risk; Emotions; Encyclopedia of DNA Elements; endophenotype; Enhancers; experience; Eye; Face; Future; gaze; Gene Expression; Genes; Genetic; Genetic Polymorphism; Genetic study; Genetic Transcription; Genetic Variation; genome editing; Goals; Human; Human Genetics; Immediate-Early Genes; in vivo; Individual; individual variation; information processing; insight; Intranasal Administration; Lead; Learning; Life; Link; Linkage Disequilibrium; Mammals; Mental disorders; Microtus; Modeling; Molecular; molecular phenotype; Mus; Mutation; neglect; Nucleus Accumbens; Oxytocin; Oxytocin Receptor; Pair Bond; Partner in relationship; Pattern; Pharmacology; Phenotype; Play; Population Heterogeneity; prairie vole; precision medicine; prevent; Process; Psychopathology; Receptor Gene; Regulation; resilience; response; reward processing; Rewards; RNA Interference; Role; Sampling; Sampling Studies; Sensory; sex; Signal Transduction; Single Nucleotide Polymorphism; SNP genotyping; social; social attachment; Social Behavior; social cognition; Social Functioning; Social Values; Stimulus; Symptoms; System; Testing; Tissues; trait; Translating; treatment strategy; Untranslated RNA; Variant; ","Genetic Regulation of Variability in Brain Oxytocin Receptors","112788","NNRS","Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section ","","","03","296916","193492","490408",""
"9891971","R44","CA","5","N","03/26/2020","03/01/2020","02/28/2021","395","R44CA213715","","PA-18-574","5R44CA213715-03","NCI:973003\","SBIR-STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","YPSILANTI","UNITED STATES","","12","079942146","US","10040007","MEKANISTIC THERAPEUTICS, LLC","MI","481976054","NARRATIVE Public Health Impact: There is an urgent need to develop more effective therapies to improve the low survival rate for metastatic colorectal cancer, where the prognosis for patients diagnosed with KRAS mutant disease is especially poor. This project is focused on evaluation of MTX-211, a novel first-in-class agent, that selectively targets EGFR and PI3 kinase, key signaling molecules implicated in the progression of KRAS mutant colorectal cancer.","10364446; 14229366 (contact); ","LEOPOLD, JUDITH S; WHITEHEAD, CHRISTOPHER EMIL (contact);","FRANCA-KOH, JONATHAN C","02/01/2017","02/28/2021","1-Phosphatidylinositol 3-Kinase; Achievement; active control; Advanced Development; Antineoplastic Agents; base; Cancer Model; Cancer Prognosis; candidate marker; Capital; Chemistry; Chemotherapy-Oncologic Procedure; Clinical; clinical development; Clinical Trials; Collaborations; colon cancer patients; Colorectal Cancer; colorectal cancer treatment; Combined Modality Therapy; commercial application; Data; design; Development; Diagnosis; Disease; Dose; effective therapy; efficacy trial; Epidermal Growth Factor Receptor; Evaluation; Fluorouracil; follow-up; Funding; Future; Immunotherapy; improved; improved outcome; In Vitro; inhibitor/antagonist; interest; Investments; KRAS2 gene; Laboratories; Lead; lead candidate; MAP Kinase Gene; Maximum Tolerated Dose; MEK inhibition; MEKs; metastatic colorectal; Michigan; Mismatch Repair; Mitogen-Activated Protein Kinases; Modeling; Molecular Profiling; Molecular Target; Mus; mutant; Mutation; novel; Oncogenic; Pathway interactions; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; Phase; phase 2 study; Phosphotransferases; Play; Population; pre-clinical; preclinical study; Process; Production; Prognostic Marker; Public Health; resistance mechanism; response; response biomarker; Risk; Role; Safety; safety study; scale up; Signal Transduction; Signaling Molecule; single molecule; Small Business Innovation Research Grant; Survival Rate; targeted agent; Testing; Therapeutic; therapy development; therapy outcome; Time; Toxicology; trial design; tumor; Universities; Up-Regulation; Xenograft Model; ","Development of MTX-211 for the Treatment of KRAS Mutant Colorectal Cancer","213715","ZRG1","Special Emphasis Panel ","","","03","","","973003",""
"9893909","R21","HD","5","N","03/24/2020","03/01/2020","02/28/2021","865","R21HD098700","SCHOOLS OF MEDICINE","PA-18-482","5R21HD098700-02","NICHD:235500\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","DAVIS","UNITED STATES","NEUROLOGY","03","047120084","US","577503","UNIVERSITY OF CALIFORNIA AT DAVIS","CA","956186153","NARRATIVE Episodic memory, the ability to remember past events in specific detail, is a fundamental aspect of cognition supporting children's capacity to face daily challenges (such as remembering to turn in one's homework), form autobiographical memories, and learn in the classroom. The hippocampus is a brain structure that is critical for episodic memory and is thought to play a fundamental role in early memory development. The proposed research will explore new approaches to examine hippocampal structure and function in healthy infants and toddlers between 18 and 30 months of age, elucidating the neural mechanisms that underlie typical episodic memory improvement and its relations to word learning.","8567143; ","GHETTI, SIMONA ;","MILLER, BRETT","03/15/2019","02/28/2021","Academic achievement; Address; Adult; Age; Age-Months; Amnesia; Anxiety; Auditory; base; Behavioral; Brain; Child; Child Support; Cognition; cognitive neuroscience; Data; Development; Developmental Process; Disease; early childhood; early experience; Episodic memory; Event; experience; Eye; Eye Movements; Face; Foundations; Functional Magnetic Resonance Imaging; Future; Hippocampus (Brain); Human; Human Development; imaging modality; Impairment; improved; in vivo; Individual; infancy; Infant; innovation; Investigation; Language; Language Development; Learning; Learning Skill; Life; Light; Literature; Memory; Mental Depression; Mental Health; Methodology; Methods; Names; Neurodevelopmental Disorder; neuroimaging; Neurologic; neuromechanism; novel; novel strategies; Performance; Play; Population; Public Health; Puppet; relating to nervous system; Reporting; Research; Role; skills; Sleep; Source; spatiotemporal; Structure; Testing; theories; Time; Toddler; Vocabulary; word learning; ","The Role of the Hippocampus in Early Memory for Words","098700","CP","Cognition and Perception Study Section ","","","02","150000","85500","235500",""
"9902474","R01","HD","5","N","03/26/2020","02/01/2020","01/31/2021","865","R01HD038384","SCHOOLS OF MEDICINE","PA-13-302","5R01HD038384-20","NICHD:595223\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","BALTIMORE","UNITED STATES","PHYSIOLOGY","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","PUBLIC HEALTH RELEVANCE    Down syndrome (DS) is the most frequent cause of intellectual disability. Using a mouse model, we have identified a potential treatment that normalizes the limited growth of a brain region called the cerebellum and also improves learning and memory. We will carry out experiments to 'translate' these findings to a clinical approach for people by understanding exactly why learning is improved, and finding suitable molecular points where drug intervention can be focused to greatest effect. We also propose to take DS research into a new era with a greatly superior rodent model for pharmaceutical and behavioral studies.","1866121; ","REEVES, ROGER H;","PARISI, MELISSA","03/01/2000","01/31/2021","Acute; Adult; Adverse drug effect; Affect; Agonist; Anatomy; Aneuploidy; Animal Model; Animals; antenatal; Area; Award; base; Behavior; behavior test; Behavioral Model; behavioral pharmacology; behavioral study; Biological Assay; biological systems; Birth; Brain; Brain region; calmodulin-dependent protein kinase II; Candidate Disease Gene; Cell Line; Cells; Cerebellum; Child; Chromosomes, Human, Pair 21; Clinic; Clinical; Clinical Trials; Cognition; cognitive function; combinatorial; Complementary DNA; Congenital cerebellar hypoplasia; craniofacial; cranium; Data; Defect; Development; Dose; Down Syndrome; Doxycycline; Drug Delivery Systems; Drug Targeting; druggable target; Dysmorphology; Electrophysiology (science); Embryo; Equilibrium; Erinaceidae; Evaluation; Exhibits; experimental study; Exposure to; GABA Antagonists; GABA-A Receptor; Generations; Genes; genetic approach; Genetic Models; Genomic approach; Grant; granule cell; Growth; Growth and Development function; Growth Factor; Hand; Hippocampus (Brain); Human Chromosomes; improved; in vivo; Individual; Injections; Intellectual functioning disability; Intervention; Investigation; Knock-out; Learning; Life; Luciferases; Mammals; Measures; Mediating; Memory; Methods; Milk; Modeling; Molecular; Morphology; morris water maze; mouse model; mouse Ts65Dn; Mus; National Institute of Child Health and Human Development; Pathway interactions; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacotherapy; Phase; Physiology; Placenta; Problem Solving; promoter; Prosencephalon; public health relevance; pup; Purkinje Cells; rat genome; Rattus; Reporter; Research; response; restoration; restraint; Rewards; Rodent Model; SHH gene; side effect; Skeleton; smoothened signaling pathway; Societies; Sonic Hedgehog Pathway; Specificity; Structural defect; Suggestion; Synaptic plasticity; Testing; Time; Transgenes; Translating; Trisomy; Work; young adult; Zebrafish; ","Genomic Approaches to Aneuploidy","038384","GHD","Genetics of Health and Disease Study Section ","","","20","401391","193832","595223",""
"9906862","R01","CA","5","N","03/26/2020","03/01/2020","02/28/2021","393","R01CA208257","SCHOOLS OF MEDICINE","PA-16-160","5R01CA208257-05","NCI:369431\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","CHICAGO","UNITED STATES","UROLOGY","07","005436803","US","6144650","NORTHWESTERN UNIVERSITY AT CHICAGO","IL","606113152","PROJECT NARRATIVE  Breast cancer is the leading cause of cancer-related deaths in American women, and one subtype, triple negative breast cancer (TNBC) is the most difficult to treat. In this project, we will investigate the novel role for the gene silencer, Polycomb Repressive Complex 2 (PCR2), in DNA-damage repair. Successful completion of this project will provide novel mechanistic insights into the crosstalk between PRC2 and PARP, a DNA-damage repair protein, in TNBC, as well as the rationale to develop combinational targeted therapies for the treatment of advanced breast cancers.","9460288; ","CAO, QI ;","FINGERMAN, IAN M","03/15/2017","02/28/2022","advanced breast cancer; Advanced Malignant Neoplasm; Affect; American; Attention; Biological Assay; BMI1 gene; BRCA1 gene; BRCA2 gene; Breast Cancer Cell; Breast Cancer Patient; breast cancer progression; Breast Carcinoma; Breast Epithelial Cells; cancer biomarkers; Cancer Etiology; cancer initiation; cancer type; cDNA Arrays; Cell Line; Cell Maintenance; Cells; Cessation of life; ChIP-seq; Chromosomal Instability; Clinical; Clinical Trials; Complex; Core Protein; Data; Data Set; Defect; Development; Diagnosis; DNA Damage; DNA Repair; DNA Repair Enzymes; DNA Repair Gene; DNA Repair Pathway; Drug Combinations; Environmental Risk Factor; Epigenetic Process; EZH2 gene; Feedback; GATA4 gene; Gene Expression; gene repression; Genes; Genomics; Growth; Histone H3; Histones; Impairment; In Vitro; inhibitor/antagonist; insight; Invaded; knock-down; Lead; loss of function; Lysine; malignant breast neoplasm; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant Neoplasms; Mass Spectrum Analysis; Mediating; member; Metastatic breast cancer; Methylation; Microarray Analysis; Modification; Molecular; Morbidity - disease rate; mortality; mutant; Neoplasm Metastasis; non-histone protein; novel; novel therapeutics; Oncogenic; Oncoproteins; Organ; Outcome; overexpression; Pathway interactions; Patients; Play; Poly(ADP-ribose) Polymerases; Polycomb; Post-Translational Protein Processing; preclinical study; prognostic value; protein H(3); Proteins; recruit; Regimen; Regulation; Reporting; response; Role; Site; STAT3 gene; Stem cells; systemic toxicity; targeted treatment; Therapeutic; therapeutic target; Tissue Microarray; Transcript; triple-negative invasive breast carcinoma; tumor growth; tumor progression; Tumor-Derived; Woman; Xenograft Model; ","The inhibitory network between EZH2 and PARP1 in triple-negative breast cancer","208257","ZRG1","Special Emphasis Panel ","","","05","256367","113064","369431",""
"9908168","R01","MH","5","N","03/25/2020","03/01/2020","02/28/2021","242","R01MH107652","SCHOOLS OF MEDICINE","PA-13-302","5R01MH107652-05","NIMH:757515\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","CHICAGO","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","005436803","US","6144650","NORTHWESTERN UNIVERSITY AT CHICAGO","IL","606113152","PUBLIC HEALTH RELEVANCE: Early irritability is a precursor to most common childhood mental disorders, but identifying 'when to worry' is challenging because infants' regulatory capacities develop so rapidly. The goal of this study is to develop a scientific evidence base beginning in infancy that distinguishes the normative irritability of early childhood from atypical irritability patterns. We will use a neurodevelopmental framework to characterize typical and atypical brain and behavioral patterns longitudinally from infancy to preschool age, including how infant irritability shapes and is shaped by proximal interactions with parents, and link these to dimensional patterns of clinical risk. Generating reliable markers of irritability that identify those infants at highest risk for developmental psychopathology lays the foundation for targeted early intervention at the earliest phase of clinical risk.","1878944; ","WAKSCHLAG, LAUREN S;","FRIEDMAN-HILL, STACIA","03/02/2016","02/28/2021","Accounting; Acoustics; Age; Anatomy; Anterior; base; Behavior; Behavioral; Brain; Child; Child Rearing; Childhood; cingulate cortex; Clinical; Clinical Pathways; clinical predictors; clinical risk; Code; cognitive task; cohort; Communities; Cross-Sectional Studies; Data; Deformity; Development; Devices; Dimensions; early childhood; Early Intervention; Elements; Environment; Event; evidence base; executive function; Fathers; follow-up; Foundations; Goals; Growth; high risk; Impairment; Individual Differences; infancy; Infant; infant monitoring; innovation; Joints; Language; Link; Longevity; Magnetic Resonance Imaging; Maps; Measures; Medial; mental disorder prevention; Mental disorders; Methods; Mothers; neural correlate; Neurocognitive; neuromechanism; novel; novel strategies; Nursery Schools; Outcome; Parents; Pattern; Performance; Phase; Phenotype; population based; Prevention; Probability; Process; Property; Psychopathology; public health relevance; rapid growth; real time monitoring; Regulation; Reporting; response; Role; Sampling; Science; Severities; Shapes; Sleep; Specific qualifier value; Structure; Surveys; Symptoms; System; Temperament; Testing; Thick; Time; Toddler; tool; Transact; Variant; Visit; vocalization; Work; ","Generating an Earlier Science of When to Worry: A Neurodevelopmental, Transactional Approach to Characterizing Irritability Patterns Beginning in Infancy","107652","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","","05","506512","251003","757515",""
"10027336","R00","NR","4","N","03/24/2020","01/21/2020","12/31/2020","361","R00NR017416","SCHOOLS OF NURSING","PA-16-193","4R00NR017416-03","NINR:248999\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","NEW YORK","UNITED STATES","NONE","12","041968306","US","5998301","NEW YORK UNIVERSITY","NY","100122300","PROJECT NARRATIVE Findings from this project will determine the viability of sleep as a treatment intervention for persons with prediabetes, thereby; expanding intervention options beyond calorie restricted diets and increased physical activity. The effects of widely prevalent sleep habits, such as restricted work day sleep and irregular sleep timing, on glucose regulation in community dwelling adults will be quantified. Raising opportunities for mitigating T2D risk based on individual sleep profiles may particularly benefit persons resistant to diet and exercise interventions, sustain the metabolic benefits reached by traditional lifestyle modification interventions, and open the door for a wide range of behavioral and environmental rhythm interventions to reduce T2D risk (e.g., light-dark exposure, timed restricted eating schedules).","11276865; ","MALONE, SUSAN KOHL;","YOON, SUNG SUG","01/21/2020","12/31/2022","Accelerometer; actigraphy; Address; Adult; American; arm; Award; base; Beds; Behavior; Behavior Therapy; Behavioral; blood glucose regulation; Body mass index; bridge program; Caloric Restriction; career; Circadian Rhythms; cohort; Communities; community intervention; community setting; Data; Data Collection; Data Set; design; Diabetes Mellitus; diabetes risk; Diet; diet and exercise; Dietary Intervention; dietary restriction; Dimensions; Disease; Eating; eligible participant; Epidemic; Exclusion; exercise intervention; Glucose; glucose monitor; Glycosylated hemoglobin A; Goals; Health; Health Promotion; Hour; Impairment; improved; Individual; Individual Differences; innovation; Insulin Resistance; insulin sensitivity; Intervention; intervention effect; Life Style Modification; Light; Measures; Mentorship; Metabolic; Metabolism; Mission; Modeling; National Health and Nutrition Examination Survey; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Outcome Measure; Pathway interactions; Persons; Pharmaceutical Preparations; Pharmacology; Phase; Physical activity; Populations at Risk; Prediabetes syndrome; prevent; primary outcome; programs; racial and ethnic; Randomized; Randomized Clinical Trials; recruit; Reporting; Research; research study; resilience; Resistance; response; Risk; Role; Sample Size; Sampling; Schedule; Self Management; skills; Sleep; sleep behavior; sleep pattern; Sleep Starts; sociodemographics; socioeconomics; stem; Structure; success; Sum; Testing; Therapeutic Intervention; Time; Training; trend; wearable sensor technology; Work; Writing; ","Personalizing Sleep Interventions to Prevent Type 2 Diabetes in Community Dwelling Adults with Pre-Diabetes","017416","NSS","Special Emphasis Panel ","","","03","157097","91902","248999",""
"10053029","R01","DA","7","N","03/24/2020","11/06/2019","02/29/2020","279","R01DA044471","SCHOOLS OF MEDICINE","PA-18-590","7R01DA044471-03","NIDA:526644\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","WINSTON-SALEM","UNITED STATES","BIOLOGY","05","937727907","US","9021205","WAKE FOREST UNIVERSITY HEALTH SCIENCES","NC","271570001","NARRATIVE The consequences of cigarette smoking constitute the greatest preventable cause of mortality and morbidity in the US. As a significant conceptual advance in the field, this proposal will evaluate 2 promising neural-circuit based strategies as tools to decrease cigarette demand, use, and the brain reactivity to smoking cues. The results from this 2 site, double blinded proposal will pave a clear pathway for the systematic development of these neural-circuit based strategies as treatments for our patients.","1860001; 7335815 (contact); ","BICKEL, WARREN K; HANLON, COLLEEN A (contact);","WALTON, KEVIN","11/06/2019","02/28/2022","","Translational approaches to TMS treatment development for smoking","044471","NPAS","Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section ","","","03","347153","179491","526644",""
"10055860","R01","CA","7","N","03/25/2020","12/01/2019","12/31/2019","393","R01CA234266","SCHOOLS OF MEDICINE","PA-18-590","7R01CA234266-02","NCI:245080\","Non-SBIR/STTR RPGs","2019","NATIONAL CANCER INSTITUTE","","MAYWOOD","UNITED STATES","BIOLOGY","07","791277940","US","4689203","LOYOLA UNIVERSITY CHICAGO","IL","601533328","Relevance to public health: Maintenance of genome stability is essential for preventing diseases including early aging, cancer, neurological diseases, and other complex diseases. There is growing evidence that environmental agents induce replication stress that result in DNA lesions and genome instability. This proposal aims to yield new insights into how replication stress is countered by cellular machineries, and may lead to new targets for improved therapies.","6822235; ","CHAI, WEIHANG ;","OBERDOERFFER, PHILIPP","12/01/2019","12/31/2023","","Molecular Modulator of RPA and RAD51 in Maintaining Genome Stability","234266","CE","Cancer Etiology Study Section ","","","02","160708","84372","245080",""
"10076558","R21","HD","5","N","03/23/2020","03/01/2020","02/28/2021","865","R21HD097557","","PA-18-482","5R21HD097557-02","NICHD:208750\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","BRONX","UNITED STATES","","14","079783367","US","10039582","ALBERT EINSTEIN COLLEGE OF MEDICINE, INC","NY","104611975","Project Narrative  Pol III-associated leukodystrophy is a progressive and untreatable neurodegenerative disease characterized by hypomyelination, loss of motor function, cognitive defects and variable additional phenotypes. We have generated a mouse model of Pol III-associated leukodystrophy to enable studies on the mechanisms of disease pathogenesis. In this work we will test the hypothesis that decreased transcription of small non- coding RNAs by Pol III leads to defects in protein synthesis in the brain and impairs neuronal function. In addition, to inform therapeutic approaches, we will test a genetic mechanism for suppressing Pol III-associated leukodystrophy phenotypes in the mice.","10405482; 1887722 (contact); ","MOIR, ROBYN ; WILLIS, IAN M (contact);","PARISI, MELISSA","03/01/2019","02/28/2021","6 year old; Affect; Age; Animals; base; Behavior; Behavioral; Biogenesis; Biological Models; Brain; Catalytic Domain; Cell Differentiation process; Cell physiology; Cellular Stress; Cerebrum; Characteristics; Chemicals; Childhood; Chronic; Clinical; Clinical/Radiologic; Cognitive deficits; cognitive function; cognitive regression; Defect; Developmental Delay Disorders; Diagnosis; Diet; Disease; disease phenotype; Disease Progression; DNA Polymerase I; DNA Polymerase III; DNA-Directed RNA Polymerase; Electron Microscopy; Electron Transport Complex III; Endocrine; Enzymes; Eukaryota; Exhibits; experimental study; Genes; Genetic; Genetic Models; Genetic Suppression; Genetic Transcription; Goals; Human; Hypodontia; Immunohistochemistry; Impairment; Intellectual functioning disability; Knock-in Mouse; Knock-out; Knockout Mice; Laboratories; leukodystrophy; Link; Magnetic Resonance Imaging; Mammals; Measures; Missense Mutation; Molecular; Motor; mouse model; Mus; Mutant Strains Mice; Mutation; Myelin; Myopia; negative affect; Nerve Degeneration; Neurodegenerative Disorders; Neurons; neuropathology; Nutritional; Obesity; Onset of illness; Pathogenesis; Patients; Phenotype; Polymerase; Population; prevent; Production; Proliferating; Protein Biosynthesis; Proteins; Radiology Specialty; Repression; Research; Resistance; response; ribosome profiling; Saccharomycetales; Sensorimotor functions; Severities; Severity of illness; targeted treatment; Testing; Therapeutic; therapeutic evaluation; Thinness; Tissues; Transfer RNA; Translations; Untranslated RNA; white matter; Work; ","Studies on Pol III-Associated Leukodystrophy","097557","ZRG1","Special Emphasis Panel ","","","02","125000","83750","208750",""
"10077638","R01","GM","3","N","03/23/2020","07/01/2019","06/30/2020","859","R01GM068803","SCHOOLS OF MEDICINE","PA-18-906","3R01GM068803-15S1","NIGMS:21068\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","WORCESTER","UNITED STATES","BIOCHEMISTRY","02","603847393","US","850903","UNIV OF MASSACHUSETTS MED SCH WORCESTER","MA","016550002","PROJECT NARRATIVE Cellular growth, development, movement and communication absolutely require accurate vesicle targeting and membrane fusion; an essential component of these fundamental cell biological processes is the exocyst complex, which is conserved from yeast to man, and has been implicated in a variety of human diseases, such as cancer, diabetes, ciliopathies, and bacterial pathogenesis. Our studies of the exocyst and its regulation of membrane fusion proteins will lead to a molecular understanding of the function of the exocyst complex. In addition, our research will also lead to the development of many technologies, constructs, reagents and ideas that will be valuable tools for studying how the exocyst complex regulates secretion in all eukaryotic cells.","1881510; ","MUNSON, MARY ;","AINSZTEIN, ALEXANDRA M","07/01/2005","06/30/2022","Animal Model; Architecture; Auxins; Binding; Biochemical; Biological; Biological Process; biophysical techniques; Biophysics; cell growth; Cell membrane; Cells; Cellular biology; Cellular Morphology; Chimeric Proteins; ciliopathy; Communication; Complex; crosslink; Cryoelectron Microscopy; Crystallography; Data; Development; Diabetes Mellitus; Dissection; Electron Microscopy; Eukaryota; Eukaryotic Cell; Event; Foundations; Funding; Genetic; Golgi Apparatus; Growth; Growth and Development function; Hormones; Human; human disease; improved; In Vitro; in vitro Assay; in vivo; Individual; insight; Investigation; Knowledge; Lead; Liposomes; Malignant Neoplasms; man; Maps; Mass Spectrum Analysis; Measures; Mechanics; Mediating; Membrane; Membrane Fusion; Methods; Modeling; Molecular; Molecular Conformation; molecular modeling; Molecular Structure; Monomeric GTP-Binding Proteins; Movement; multidisciplinary; mutant; Myosin ATPase; Negative Staining; Neurons; neurotransmission; novel; Organelles; Organism; Pathogenesis; Pathway interactions; Plant Roots; Play; Process; protein complex; Proteins; Publishing; Quality Control; rab GTP-Binding Proteins; Reagent; Recycling; Regulation; Research; Resolution; rho GTP-Binding Proteins; Role; Saccharomyces cerevisiae; Secretory Vesicles; single molecule; Site; SNAP receptor; Specificity; Spectrum Analysis; Structure; System; Techniques; Technology; Testing; three dimensional structure; Time; tool; trafficking; Vesicle; vesicle transport; Yeast Model System; Yeasts; ","Structure and Function of the Exocyst Complex","068803","","","","S1","15","12578","8490","21068",""
"10085711","R44","AA","4","N","03/24/2020","03/25/2020","02/28/2021","273","R44AA028164","","PA-18-573","4R44AA028164-02","NIAAA:844191\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM","","New York","UNITED STATES","","07","079901181","US","10042499","HEALTH RHYTHMS, INC.","NY","10002","PROJECT NARRATIVE HealthRhythms, Inc. is on a mission to become the world leader in tracking clinically meaningful behavioral health rhythms in order to provide automated intervention advice to patients around the globe. The work we propose in this Fast Track SBIR application will enable HealthRhythms create and test a smartphone application to address the sleep problems experienced by individuals with alcohol use disorder who are in early recovery. Since such sleep problems represent a major risk factor for relapse, this intervention app has the potential to reduce the risk of relapse and, in so doing, improve the lives of individuals with AUD and reduce the costs of their healthcare.","1861111; ","FRANK, ELLEN ;","HAGMAN, BRETT THOMAS","09/15/2019","02/28/2022","Abstinence; addiction; Address; Affect; alcohol abstinence; alcohol use disorder; American; Anxiety; base; Behavior; Behavior monitoring; Behavior Therapy; Behavioral; behavioral health; Cellular Phone; Circadian Rhythms; Clinical; Cognitive Therapy; Complex; cost; Cues; Data; depressive symptoms; Development; drinking; Education; efficacy testing; Environment; experience; Family; Feedback; Follow-Up Studies; Funding; Goals; Grant; Health; Healthcare; Heart Diseases; Hygiene; Hypertension; immune function; improved; indexing; Individual; interest; Intervention; Interview; intimate behavior; Measurement; Measures; Mediating; Mediation; Mediator of activation protein; member; Mental Depression; Mental disorders; Mission; mobile application; mobile computing; Modeling; Monitor; Outcome; Participant; Pathway interactions; patient population; Patients; Personal Satisfaction; personalized intervention; Phase; Polysomnography; Population; primary outcome; Productivity; psychoeducation; psychoeducational intervention; Qualitative Methods; Randomized Controlled Trials; Recovery; reduce symptoms; Regulation; Relapse; relapse risk; Rest; Risk; Risk Factors; Role; secondary outcome; sensor; Series; Severities; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Small Business Innovation Research Grant; smartphone Application; social; Structure; Surveys; Technology; Telephone; Testing; Treatment outcome; Universities; Utah; welfare; Work; ","Smartphone-Based Intervention for Sleep Disturbance in Individuals Recovering from Alcohol Use Disorder","028164","ZRG1","Special Emphasis Panel ","","","02","","","844191",""
"10103922","R18","HS","7","N","03/27/2020","10/01/2019","03/31/2020","226","R18HS026662","SCHOOLS OF PHARMACY","PA-17-260","7R18HS026662-02","AHRQ:268656\","OTHER RESEARCH-RELATED","2019","AGENCY FOR HEALTHCARE RESEARCH AND QUALITY","","SALT LAKE CITY","UNITED STATES","PHARMACOLOGY","02","009095365","US","514002","UNIVERSITY OF UTAH","UT","841128930","Project Narrative Torsades de Pointes (TdP), is a life-threatening arrhythmia associated with the prolongation of the heart rate- corrected QT (QTc) interval on the electrocardiogram (ECG), and if unrecognized and untreated, patients can experience multiple TdP episodes, leading to ventricular fibrillation and sudden cardiac death. To reduce exposure to medications that can affect the QTc interval, computer algorithms have been successfully developed and implemented in critical care units at several hospitals. The purpose of this project is to disseminate and evaluate a risk score for QTc interval prolongation across all care units at 28 hospitals that have a high proportion of underserved American Indian, Latino, and economically disadvantaged populations, include rural critical access facilities.","1911825; ","MALONE, DANIEL C;","LOMOTAN, EDWIN A","04/01/2019","03/31/2021","","Dissemination and Implementation of QT Risk Clinical Decision Support","026662","HITR","Healthcare Information Technology Research ","","","02","","","268656",""
"10134892","Y01","AI","","N","","","","","Y01AI200270","","","AAI20027001-1-0-1","NIAID:180000\","INTERAGENCY AGREEMENTS","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","","","","","","","","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","","","16428146; ","HEWLETT, INDIRA ;","","","","Agreement; Antibodies; Antigens; base; Biological Assay; Cameroon; Cells; Diagnostic; diagnostic assay; Diagnostic tests; Evaluation; Generations; genome sequencing; HIV; HIV Antigens; National Institute of Allergy and Infectious Disease; next generation; Performance; Pharmaceutical Preparations; Plasma; receptor; Recombinants; repository; Research; Sampling; Tropism; vaccine trial; Viral Load result; Virus; whole genome; Work; ","HIV Characterization","","","","","","","","","180000",""
"9703471","P01","AG","2","N","03/25/2020","04/01/2019","03/31/2020","","P01AG014449","","PAR-18-297","2P01AG014449-22","NIA:692625\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","PHOENIX","UNITED STATES","","07","131606022","US","2052813","ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER","AZ","850134409","","2095212; ","COUNTS, SCOTT E;","","","","Address; Alzheimer's Disease; Amyloid; Antibodies; Automobile Driving; Basal Nucleus of Meynert; base; Binding; Binding Sites; Biochemical; Bioinformatics; Biological Assay; Brain; Brain Diseases; Cell Nucleus; cholinergic; cingulate cortex; Cognitive; Collaborations; connectome; Data; Deacetylase; Dementia; density; Disease; Disease Progression; Elderly; Epitopes; Evolution; frontal lobe; Functional disorder; Gene Expression Profiling; Glutamates; Goals; Human; Impaired cognition; Inflammation; Inflammatory; insight; laser capture microdissection; Mediating; Messenger RNA; Metabolic; Metabolic Pathway; Metabolism; Methods; MicroRNAs; mild cognitive impairment; miRNA expression profiling; Molecular; Molecular Weight; monomer; mRNA Stability; Nerve Degeneration; nerve supply; Neurobiology; Neurofibrillary Tangles; neuron loss; Neurons; neuropathology; neurotoxicity; novel; Optics; overexpression; Pathologic; Pathology; Pathway interactions; Pattern; Phosphoric Monoester Hydrolases; Phosphotransferases; pre-clinical; Principal Investigator; programs; protein expression; Protein Isoforms; Protein phosphatase; Regulatory Pathway; Reporter; Research; Respiration; RNA Splicing; Sampling; SIRT1 gene; Site; Site-Directed Mutagenesis; spatiotemporal; Spliceosomes; Synapses; Synaptic plasticity; Synaptic Transmission; targeted treatment; tau aggregation; tau expression; tau phosphorylation; tau Proteins; tau-1; tau-protein kinase; Testing; Therapeutic; Therapeutic Intervention; Tissues; Transcript; Untranslated Regions; Untranslated RNA; validation studies; ","Project 1 (MSU)-Neurofibrillary tangle evolution in mild cognitive impairment","014449","ZAG1","Special Emphasis Panel ","7796","","22","571270","121355","","692625"
"9703473","P01","AG","2","N","03/25/2020","04/01/2019","03/31/2020","","P01AG014449","","PAR-18-297","2P01AG014449-22","NIA:426678\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","PHOENIX","UNITED STATES","","07","131606022","US","2052813","ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER","AZ","850134409","","8659956; ","IKONOMOVIC, MILOS D;","","","","AD pathology; Address; Alzheimer's Disease; Amyloid; Amyloid beta-Protein; amyloid pathology; Anterior; Attenuated; Autopsy; Basal Nucleus of Meynert; Binding; Biochemistry; Biological Assay; Brain; Brain region; Case Study; cholinergic; cingulate cortex; Clinical; Cognition; Cognitive; cognitive testing; Collaborations; connectome; cytokine; Data; Dementia; Denervation; Disease; Disease Progression; Down-Regulation; Drug Targeting; Elderly; enzyme activity; Enzyme-Linked Immunosorbent Assay; Evaluation; Exhibits; frontal lobe; Functional Magnetic Resonance Imaging; Glutamates; Goals; Image; imaging study; Immunofluorescence Microscopy; Immunohistochemistry; Impaired cognition; In Vitro; insight; Ligands; Liquid Chromatography; Measures; Messenger RNA; mild cognitive impairment; Molecular Conformation; Morphology; nerve supply; neural circuit; Neurobiology; neurochemistry; neuroinflammation; Neuronal Plasticity; neuropathology; Neuropsychology; neurotransmitter release; Neurotransmitters; new therapeutic target; novel; novel therapeutics; Onset of illness; Pathology; Pharmacotherapy; Positron-Emission Tomography; pre-clinical; preservation; Presynaptic Terminals; prevent; Proteins; Proteomics; Religion and Spirituality; resilience; Resistance; response; Study Subject; Synapses; Synaptosomes; System; tandem mass spectrometry; tau Proteins; Testing; Tissues; Tracer; Translational Regulation; Universities; Up-Regulation; ","Project 4 (Pitts)-Cholinergic and amyloid alteration in mild cognitive impairment","014449","ZAG1","Special Emphasis Panel ","7798","","22","305323","121355","","426678"
"9841175","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:189886\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE The Administrative Core of the UK-SRC will continue to promote problem-based, solution-oriented research to reduce exposure and/or negative health impacts associated with exposure to a subclass of persistent halogenated chemicals (e.g. PCBs, TCE, and PFAS). This will be accomplished by using an innovative transdisciplinary research approach that brings together biomedical and environmental scientists, engineers, and trainees using an integrative administrative structure that links together individual projects and cores. The Administrative Core will ensure the continued relevance of the proposed research through bi-directional communication with the SRP and SRP staff, academia, the general public and relevant federal and state communities of practice (e.g. EPA, ATSDR, KYDEP) as well as communities of impact in Appalachia.","1897514; ","HENNIG, BERNHARD ;","","","","Academia; Address; Advisory Committees; Analytical Chemistry; Animal Model; Animals; Appalachian Region; arm; base; Biological Monitoring; Biomedical Research; Chemicals; Clinical Sciences; Communication; Communities; Community of Practice; Complex; Coupled; crosslink; Data; Data Analyses; data management; Databases; design; Detection; Development; disorder risk; Ecology; Educational workshop; Engineering; Ensure; Environment; Environmental Engineering technology; Environmental Exposure; Environmental Health; Evaluation; Event; Exercise; experience; Exposure to; Funding; General Population; Goals; Government Agencies; Grant; Health; healthy lifestyle; Human; Human Resources; Individual; Industry; Information Dissemination; Infrastructure; innovation; Institutes; Internships; Intervention; Investigator-Initiated Research; Kentucky; Leadership; Life Style; Link; Longevity; Maintenance; materials science; meetings; member; Mentorship; multidisciplinary; National Institute of Environmental Health Sciences; novel; nutrition; Physical activity; pollutant; Polychlorinated Biphenyls; Positioning Attribute; prevent; Prevention; Preventive Intervention; Process; Productivity; programs; ranpirnase; remediation; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk; Role; Science; Scientist; Structure; Superfund; superfund chemical; Targeted Research; Technology; technology development; Technology Transfer; Testing; Toxic effect; Toxicity Tests; Training; Training Activity; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Water; webinar; ","Administration Core","007380","ZES1","Special Emphasis Panel ","5735","","22","130955","58931","","189886"
"9853041","R01","GM","5","N","03/27/2020","02/01/2020","01/31/2021","859","R01GM115584","SCHOOLS OF VETERINARY MEDICINE","PA-13-302","5R01GM115584-04","NIGMS:300158\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","CHAMPAIGN","UNITED STATES","VETERINARY SCIENCES","13","041544081","US","577704","UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN","IL","618207406","PROJECT NARRATIVE Recently, it has been shown that epoxygenases convert dietary ?-3 and ?-6 fatty acids into eicosanoids that mediate beneficial anti-inflammatory and cardiovascular effects. Herein we will unveil the biochemical mechanism of a CYP2J2, an epoxygenases highly expressed in the cardiovascular system.","10512535; ","DAS, ADITI ;","GARCIA, MARTHA","04/01/2017","01/31/2022","Acids; Active Sites; Amiodarone; Anti-inflammatory; aqueous; Arachidonic Acids; Binding; Binding Proteins; Biochemical; Biochemistry; Cardiac Myocytes; Cardiotoxicity; Cardiovascular Diseases; cardiovascular health; Cardiovascular Physiology; Cardiovascular system; Cholesterol; Complex; Consumption; CYP2J2 gene; design; Detection; Diet; Dietary Fatty Acid; Doxorubicin; Eicosanoids; Electron Transport; Electrostatics; Endocannabinoids; Environment; Enzyme Interaction; Enzymes; Epithelium; Epoxy Compounds; Exhibits; Exogenous Factors; fatty acid metabolism; Fluorescence Spectroscopy; Future; Generations; Goals; Health Benefit; Heart; Homeostasis; Human; Inflammation; innovation; Kinetics; Link; Linoleic Acids; lipid mediator; Lipids; Literature; Mass Spectrum Analysis; Mediating; Mediator of activation protein; Membrane; Membrane Lipids; Metabolism; Methodology; Methods; Muscle Cells; nanodisk; novel; novel strategies; Omega-3 Fatty Acids; Omega-6 Fatty Acids; Outcome; Oxidation-Reduction; Pathway interactions; Pharmaceutical Preparations; Physiological; Play; Positioning Attribute; Process; Proteins; Role; Solubility; Spectrum Analysis; Techniques; Terfenadine; Testing; therapeutic development; therapeutic target; Thermodynamics; Work; ","Biochemical Mechanism of Eicosanoid Synthesizing Enzymes","115584","BBM","Biochemistry and Biophysics of Membranes Study Section ","","","04","197500","102658","300158",""
"9853532","P20","GM","1","N","03/24/2020","12/01/2019","11/30/2020","","P20GM130418","","PAR-18-266","1P20GM130418-01A1","NIGMS:266724\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MISSOULA","UNITED STATES","","00","010379790","US","1381006","UNIVERSITY OF MONTANA","MT","598124104","","8850972; ","WARD, TONY JOHN;","","","","behavioral response; career; Child; Child Health; Communities; Complement; Consult; County; Data; Data Collection; design; Development; economic evaluation; Economics; educationally disadvantaged; Ensure; epidemiologic data; epidemiological model; Evaluation; experience; Face; frontier; Funding; Future; Geography; Grant; Health; health disparity; health economics; Health Promotion; improved; Intervention; Intervention Studies; Investments; Low income; Medically Underserved Area; Methods; Modeling; Montana; Outcome; Participant; Pathway interactions; Pattern; Persons; Phase; Prevention; Prevention Research; Process; programs; Publications; Qualitative Research; recruit; Research; Research Personnel; Research Project Grants; Reservations; Risk; Rural; rural area; Rural Community; Rural Health; rural setting; Structure; Surveys; theories; therapy design; training opportunity; Vulnerable Populations; ","Stakeholder Engagement and Intervention Support Core","130418","ZGM1","Special Emphasis Panel ","7780","A1","01","188250","78474","","266724"
"9853534","P20","GM","1","N","03/24/2020","12/01/2019","11/30/2020","","P20GM130418","","PAR-18-266","1P20GM130418-01A1","NIGMS:234602\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MISSOULA","UNITED STATES","","00","010379790","US","1381006","UNIVERSITY OF MONTANA","MT","598124104","","11671022; ","LANDGUTH, ERIN L;","","","","Acute; Address; Affect; Air; Air Pollution; Algorithms; Area; Assimilations; Asthma; Biological Models; Bronchiectasis; Child; Childhood; Chronic lung disease; Climate; Communicable Diseases; Communities; Complex; Data; data modeling; design; Disease Management; dynamic system; Economics; Ensure; Environmental Risk Factor; Epidemic; Event; experience; fine particles; Future; Geography; Goals; Health; health care availability; Health Personnel; Health Professional; Hospitalization; Household; Housing; improved; Incidence; indexing; Indoor Air Quality; Infection; infection risk; Influenza; Intervention; Investigation; Link; Lower Respiratory Tract Infection; Maps; mathematical model; Measures; Medical Records; Modeling; Montana; mortality; multiple data sources; neglect; novel; nutrition; Performance; Policies; Pollution; Populations at Risk; Prevalence; Prevention Research; Process; prospective; Public Health; Reliability of Results; Resolution; respiratory health; Respiratory Tract Infections; Risk; Risk Assessment; Rural; rural area; Schools; social; sociodemographic factors; sociodemographics; Socioeconomic Factors; socioeconomics; spatiotemporal; Statistical Models; Stream; Structure; Testing; Time; tool; Translating; trend; Uncertainty; Water Pollution; weather patterns; Wildfire; ","Project 2: Mathematical modeling of factors that influence children's respiratory health","130418","ZGM1","Special Emphasis Panel ","7782","A1","01","163946","70656","","234602"
"9854059","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:258807\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","9827663; ","LUTZ, CATHLEEN M;","","","","Abbreviations; Alleles; animal care; Animals; anticancer research; assay development; biosecurity; Cancer Center; Cancer Model; Cellular biology; Clustered Regularly Interspaced Short Palindromic Repeats; Complement; Complex; Conceptions; Consultations; Core Grant; cost effective; design; Development; embryonic stem cell; Engineered Gene; Engineering; Ensure; experience; Experimental Designs; gene function; Gene Transfer Techniques; Gene-Modified; Genes; Genetic; Genetic Engineering; genetic manipulation; genetic technology; genetic variant; Genetically Engineered Mouse; Genome engineering; Genotype; In Vitro; in vivo; Inbreeding; instrumentation; Laboratories; Laboratory Research; Lead; Leadership; Mammalian Cell; medical specialties; member; Methods; Microinjections; Modeling; Modernization; Modification; Molecular; mouse genome; mouse model; Mouse Strains; Mus; mutant; Mutation; Names; next generation; novel; Preparation; Process; Production; Reagent; reagent testing; recombinant virus; Reporting; Reproductive Biology; Research Personnel; Resource Development; Resource Sharing; Resources; Services; Specialist; Study models; success; targeted nucleases; Technical Expertise; Technology; Testing; tool; Training; Transgenes; Validation; Viral Vector; Virus Diseases; Work; zygote; ","Genetic Engineering Technologies Shared Resource","034196","NCI","Subcommittee H - Clinical Groups ","7973","","34","149217","109590","","258807"
"9867660","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:90232\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Administrative Supplement; anticancer research; Applications Grants; Area; Attention; Award; base; Cancer Center Support Grant; Cancer Control; cancer prevention; Cancer Survivor; Cancer Survivorship; central database; Charge; Clinical Trials; Collaborations; Colorado; Cost Sharing; Data; Data Collection; data warehouse; Databases; Development; Doctor of Philosophy; Enrollment; Ensure; exercise program; exercise regimen; experience; Funding; Future; Genomics; Goals; Grant; Growth; Health; Human; innovation; Institution; interest; investigator-initiated trial; Investments; Lead; Leadership; Malignant Neoplasms; Measurable; Measures; Medicine; member; Mission; Modeling; Monitor; Outcome; Patients; Peer Review; personalized medicine; Philanthropic Fund; Pilot Projects; population health; programs; Proteomics; Protocols documentation; Publications; Published Comment; Quality of life; Reporting; repository; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Source; special interest group; success; Supervision; survivorship; Time; transcriptomics; Translating; Translational Research; tumor; Universities; Vision; Wellness Center; Writing; Xenograft procedure; ","Developmental Funds","046934","NCI","Subcommittee H - Clinical Groups ","5058","","32","58358","31874","","90232"
"9867666","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:159142\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Adopted; anticancer research; aptamer; base; Basic Science; Bioinformatics; Biological Assay; biomarker development; biomarker discovery; Biometry; Budgets; Cancer Center Support Grant; cancer genomics; cancer subtypes; cancer type; cell type; Cells; Clinical Sciences; Collaborations; Colorado; Computer software; Consultations; cost effective; CRISPR library; Data; Data Analyses; Decision Making; design; Development; Diagnosis; Diagnostic; digital; DNA; DNA Microarray Chip; DNA Mutational Analysis; Doctor of Philosophy; Education; empowered; Epigenetic Process; epigenetic profiling; epigenomics; Equipment; Evaluation; experience; Experimental Designs; experimental study; Fees; functional genomics; Funding; Future; Galaxy; Gene Chips; Gene Expression; Gene Expression Profiling; Genes; Genetic Markers; Genetic Predisposition to Disease; Genetic Transcription; genome sequencing; genome-wide; genome-wide analysis; genomic data; Genomics; Genomics Shared Resource; Grant; Human; Individual; insight; Institutes; Investigation; Malignant Neoplasms; member; Methodology; Microarray Analysis; Mus; next generation sequencing; Oligonucleotide Microarrays; Pathogenesis; Pathway interactions; Peer Review; programs; protein profiling; Proteins; Proteome; Proteomics; Protocols documentation; Publications; Research; Research Personnel; RNA; Series; Services; single molecule; small hairpin RNA; SNP genotyping; Students; System; Technology; Therapeutic; Time; Tissues; tool; Training; transcriptome; transcriptomics; Translational Research; Translations; tumor; United States National Institutes of Health; Universities; Variant; whole genome; ","Genomics Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5063","","32","102673","56469","","159142"
"9867677","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:70379\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","American College of Radiology Imaging Network; American Society of Clinical Oncology; animal imaging; Animals; anti-cancer therapeutic; Area; Arts; aurora kinase; Autophagocytosis; base; Basic Science; bench to bedside; Binding; biobank; Bioinformatics; Biological Markers; Biological Models; Biological Products; Biological Sciences; biomarker selection; Biometry; BRAF gene; Breast Cancer cell line; Cancer Burden; Cancer Center; Cancer Center Support Grant; cancer therapy; Cancer Therapy Evaluation Program; Caring; Cell Line; Characteristics; Clinical; clinical application; clinical development; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; college; Colorado; Communication; Companions; comparative; Contracts; Cyclosporine; data management; Development; Developmental Therapeutics Program; Diagnosis; Disease; Drug Combinations; Drug Delivery Systems; drug development; drug discovery; Drug Discovery Groups; Drug Industry; Evaluation; Experimental Models; first-in-human; Flow Cytometry; Focus Groups; Fostering; Functional Imaging; Funding; Future; Genes; Genomics; Goals; Grant; Image; Immunotherapy; in vivo; Individual; Industry; inhibitor/antagonist; Institution; interest; Investigation; Investigational Therapies; Investments; Joints; kinase inhibitor; Laboratory Research; Laboratory Study; Leadership; Link; Malignant Neoplasms; MAP2K1 gene; medical schools; meetings; MEKs; member; Mission; Modality; Molecular; molecular pathology; multidisciplinary; National Surgical Adjuvant Breast and Bowel Project; Nature; neoamphimedine; novel; novel anticancer drug; novel drug combination; novel therapeutics; oncology trial; Outcome; Patient Selection; Patients; peer; Peer Review; personalized medicine; Pharmacology; Pharmacy facility; Phase; phase II trial; Phase II/III Trial; pre-clinical; Pre-Clinical Model; Precision therapeutics; preclinical development; Preclinical Drug Development; preclinical study; Preclinical Testing; Process; programs; Public Health; Publications; radiation delivery; Radiation Therapy Oncology Group; Radiobiology; Reagent; Research; research clinical testing; Research Personnel; Resistance; Resource Sharing; response; Sampling; Schools; Science; Scientist; Selection Criteria; Southwest Oncology Group; Stem cells; targeted agent; targeted biomarker; targeted treatment; Testing; therapeutic development; therapeutic evaluation; Time; Tissues; Toxicity Tests; TP53 gene; translational scientist; tumor; tumor microenvironment; United States National Institutes of Health; Universities; Update; Validation; Veterinary Medicine; Vision; Work; Xenograft procedure; ","Developmental Therapeutics Program","046934","NCI","Subcommittee H - Clinical Groups ","5074","","32","53265","17114","","70379"
"9875272","R01","DE","5","N","03/24/2020","03/01/2020","02/28/2021","121","R01DE025832","SCHOOLS OF DENTISTRY/ORAL HYGN","PA-15-135","5R01DE025832-05","NIDCR:658631\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH","","GAINESVILLE","UNITED STATES","DENTISTRY","03","969663814","US","513806","UNIVERSITY OF FLORIDA","FL","326115500","PUBLIC HEALTH RELEVANCE: Dental caries, periodontal diseases and fungal infections of the oral cavity are all associated with changes in the composition of the microorganisms colonizing the tissues of the mouth; with certain bacteria being prominent in health and other organisms abundant in disease. Probiotic therapy, where naturally occurring bacteria with beneficial properties are used to promote health by preventing the establishment or outgrowth of pathogens, holds tremendous promise for control of oral diseases. The research to be conducted here unites the most current understanding of the cause of oral diseases with cutting-edge genomic, molecular, in vitro, in vivo and clinical studies to dissect the basis for probiotic effects of beneficial bacteria. Collectively, the research will establish a sound foundation for the design of new therapies to detect, diagnose and prevent dental caries and other oral infectious diseases.","1883700; ","BURNE, ROBERT A;","LUMELSKY, NADYA L","03/01/2016","02/28/2021","Address; Amino Acids; Animal Model; Animals; Antibiotics; Arginine; Arginine deiminase; Bacteria; bacteriocin; base; Behavior; Biochemical; Biological; Biological Markers; Biological Models; biomarker identification; Clinical; Clinical Research; commensal bacteria; Communicable Diseases; comparative genomics; Coupled; dental biofilm; Dental caries; Dental Plaque; design; Development; Diagnosis; Disease; efficacy evaluation; Enzymes; Formulation; Foundations; functional genomics; Future; Gene Expression Profile; Genetic; Genetic Markers; Genomics; Goals; Growth; Health; Health Promotion; Heterogeneity; Human; Human Microbiome; Hydrogen Peroxide; In Vitro; in vivo; Individual; Light; Metabolic; Metabolic Pathway; Metabolism; Metagenomics; metatranscriptomics; Methodology; microbial; microbiome research; microbiota; microorganism; Modeling; Molecular; Monitor; mouse model; Mouth Diseases; Mycoses; novel; novel marker; novel therapeutics; oral bacteria; oral biofilm; Oral cavity; Oral health; oral infection; oral microbiome; oral pathogen; Organism; Outcome; Oxidases; pathogen; Peptide Hydrolases; Periodontal Diseases; Periodontitis; pH Homeostasis; Phenotype; prebiotics; prevent; probiotic therapy; Probiotics; Property; public health relevance; Research; Risk Assessment; Rodent Model; Role; Running; Science; Solid; sound; Source; Streptococcus; Streptococcus mutans; structural genomics; System; Testing; Tissues; tool; weapons; Work; ","Probiotics that moderate pH and antagonize pathogens to promote oral health","025832","ZRG1","Special Emphasis Panel ","","","05","454845","203786","658631",""
"9882232","R01","AR","5","N","03/26/2020","03/01/2020","02/28/2021","846","R01AR071649","EARTH SCIENCES/RESOURCES","PA-16-160","5R01AR071649-04","NIAMS:341000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","WEST LAFAYETTE","UNITED STATES","VETERINARY SCIENCES","04","072051394","US","1481402","PURDUE UNIVERSITY","IN","479072114","Narrative This project aims to explore a novel signaling mechanism regulating the function of muscle satellite cell ? muscle resident stem cells that are important for muscle maintenance and regeneration, especially under disease and aging conditions. Knowledge from the proposed work will benefit future studies into treatment of debilitating muscular dystrophy diseases and age-related muscle wasting. ","9570841; ","KUANG, SHIHUAN ;","BOYCE, AMANDA T","03/01/2017","02/28/2022","Ablation; adult stem cell; Affect; age related; Aging; Biological Process; Cell Cycle; cell growth; Cell Maintenance; Cell Nucleus; Cell physiology; Cell Survival; cell type; Cells; Cytoplasm; Degenerative Disorder; Deterioration; Disease; DNA Maintenance; Embryo; FRAP1 gene; Future; Gene Expression; Goals; Growth; improved; Injury; injury and repair; insight; Knock-out; Knowledge; Label; Lipids; Long-Term Effects; Maintenance; Malignant Neoplasms; Mediating; Molecular; Mus; Muscle; Muscle function; muscle hypertrophy; muscle regeneration; Muscle satellite cell; Muscular Atrophy; Muscular Dystrophies; Mutate; Myoblasts; myogenesis; Natural regeneration; notch protein; novel; novel strategies; Nuclear; Outcome; overexpression; Pathologic; Pathway interactions; Phenotype; Phosphoric Monoester Hydrolases; Phosphorylation; postnatal; Proliferating; Property; Protein phosphatase; Proto-Oncogene Proteins c-akt; PTEN gene; regenerative; Regulation; response; Role; satellite cell; self-renewal; Signal Transduction; Skeletal Muscle; Specificity; stem cell population; Stem cells; Time; Tumor Suppressor Proteins; Work; ","PTEN Function in Satellite Cells","071649","SMEP","Skeletal Muscle Biology and Exercise Physiology Study Section ","","","04","220000","121000","341000",""
"9884771","R24","EY","5","N","03/25/2020","02/01/2020","01/31/2021","867","R24EY028767","","PAR-17-099","5R24EY028767-03","NEI:1176331\","OTHER RESEARCH-RELATED","2020","NATIONAL EYE INSTITUTE","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","PROJECT NARRATIVE Patients with a corneal disease called a 'limbal stem cell deficiency' lose their vision and ultimately become blind because they develop an opaque cornea that is unable to transmit light to the retina. We discovered a new gene called 'ABCB5' that is expressed on limbal stem cells that can be used to purify these cells for transplantation to affected patients. The goal of this project is to translate our laboratory research findings to develop new clinically relevant ABCB5 stem cell-based therapies to treat these patients.","8148663; 7554725 (contact); 1879572; ","FRANK, MARKUS H.; FRANK, NATASHA Y (contact); KSANDER, BRUCE R;","AGARWAL, NEERAJ","04/01/2018","01/31/2023","Affect; Allogenic; Allografting; Apoptotic; Applications Grants; Autologous; Bilateral; Binding; biobank; blind; Blindness; Boston; Cell Maintenance; Cell Surface Proteins; Cell Therapy; Cell Transplantation; Cells; Chronic; Clinical; clinically relevant; Cornea; Corneal Diseases; corneal epithelium; Corneal Stroma; Data; Dermal; Disease; Ear; Epithelial Cells; experimental study; Eye; Genes; Genetic; Goals; Hospitals; Human; human model; Immune system; Immunity; immunodeficient mouse model; Immunosuppressive Agents; improved; In Vitro; Inflammation; Intestines; Laboratories; Laboratory Research; Light; limbal; Malignant Neoplasms; member; Methods; Monoclonal Antibodies; mouse model; Multipotent Stem Cells; Mus; Natural regeneration; Nature; neovascularization; novel strategies; Ophthalmology; patient population; Patients; Pediatric Hospitals; Procedures; Production; prospective; Publishing; real time monitoring; regenerative; Reporter; Research; Research Personnel; restoration; Retina; Retinal; Role; Skin; Source; Specimen; stem cell niche; stem cell population; stem cell therapy; Stem cell transplant; Stem cells; success; Therapeutic; Therapeutic Uses; Tissue Transplantation; Tissues; Transgenic Organisms; Translating; Translations; transplant model; Transplantation; Vision; Woman; ","Multipotent ABCB5-positive cell therapeutics for corneal disease","028767","ZEY1","Special Emphasis Panel ","","","03","1008263","168068","1176331",""
"9887322","R01","AI","2","N","03/23/2020","03/23/2020","02/28/2021","855","R01AI079293","SCHOOLS OF MEDICINE","PA-19-056","2R01AI079293-11","NIAID:835666\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","WORCESTER","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","603847393","US","850903","UNIV OF MASSACHUSETTS MED SCH WORCESTER","MA","016550002","Project Narrative Malaria is caused by Plasmodium, a parasite that is spread by mosquitoes, and the disease is often characterized by a high fever and other flu-like symptoms. The disease affects all organs of the body and can cause a heightened immune response that can lead to death; the World Health Organization reported that in 2017 there were ~435,000 deaths due to malaria. To better treat and prevent malaria, the goal of this proposal is to understand how the body?s immune system detects Plasmodium and identify the genes and pathways responsible for responding to and eliminating this parasite.","8244005; 6256752 (contact); ","FITZGERALD, KATHERINE A.; GOLENBOCK, DOUGLAS T (contact);","PESCE, JOHN T","09/24/2009","02/28/2025","3-Dimensional; Acute; acute infection; Affect; AIM2 gene; Anemia; Animal Model; Antigen-Antibody Complex; ATAC-seq; Bacterial Infections; base; Brazil; Cell Culture Techniques; Cell Nucleus; Cells; Cerebrum; Cessation of life; Chromatin; chromatin modification; Clinical; Culicidae; cytokine; Cytokine Gene; cytokine release syndrome; Data; defined contribution; Disease; DNA; DNA-Binding Proteins; ds-DNA; Epigenetic Process; epigenetic regulation; Exposure to; Falciparum Malaria; Fever; flu; Funding; gain of function; Gene Expression; Generations; Genes; Genetic; Genetic Transcription; Goals; Grant; Heme; hemozoin; Human; Immune; immune activation; Immune response; Immune Response Genes; Immune system; Immunologic Memory; immunoregulation; In Vitro; in vivo; in vivo Model; Inflammasome; Inflammatory; Infrastructure; Innate Immune Response; Innate Immune System; Interferon Type I; Interferons; Interleukin-12; Knockout Mice; Knowledge; Lead; Leukocytes; Life; Ligands; Ligation; Lymphocyte Subset; Lymphoid Cell; Malaria; malaria infection; Manuscripts; Mediating; Methods; Modeling; Modification; Molecular; Monitor; monocyte; Mus; Natural Immunity; novel; nucleic acid binding protein; Nucleic Acids; Organ; Paper; Parasites; Pathway interactions; Patients; Peer Review; Phagocytes; Phagolysosome; Plasmodium; Plasmodium falciparum; Plasmodium vivax; prevent; Process; Production; promoter; Publications; receptor; Regulation; Reporting; response; Role; Sampling; sensor; Signal Transduction; Site; Symptoms; systemic inflammatory response; T-Lymphocyte Subsets; Toll-like receptors; Toxin; Training; Untranslated RNA; Vivax Malaria; Work; World Health Organization; ","Innate Immune Activation in Malaria","079293","ZRG1","Special Emphasis Panel ","","","11","498905","336761","835666",""
"9889114","F31","DK","5","N","02/25/2020","03/26/2020","03/25/2021","847","F31DK116536","SCHOOLS OF MEDICINE","PA-16-309","5F31DK116536-03","NIDDK:34814\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","DETROIT","UNITED STATES","GENETICS","13","001962224","US","9110501","WAYNE STATE UNIVERSITY","MI","482024050","Project Narrative Dysregulation of adipose tissue due to chronic overnutrition contributes directly to the etiology of Type 2 Diabetes. Expanding the catabolic phenotypes in adipose tissue via activation of adrenergic signaling improves energy balance and insulin sensitivity. In order to exploit this remodeling of adipose tissue for therapeutic benefit, this project seeks to understand the mechanisms by which adrenergic signaling expands the population of catabolic adipocytes in vivo.","14970685; ","BURL, RAYANNE ;","CASTLE, ARTHUR","03/26/2018","03/25/2021","Address; Adipocytes; Adipose tissue; Adrenergic Agents; Adrenergic Receptor; Adult; Anatomy; angiogenesis; beta-adrenergic receptor; Blindness; Brown Fat; Capillary Endothelial Cell; Cardiovascular Diseases; cell type; Cells; Chronic; Comorbidity; Complex; Coupled; Data; Denervation; Dorsal; Economic Burden; Emerging Technologies; energy balance; Energy Metabolism; Epidemic; Etiology; experience; Fluorescent in Situ Hybridization; Gene Expression Profiling; Genetic; Goals; Health; Heterogeneity; Human; Impairment; improved; in vivo; Incidence; innovation; Insulin Resistance; insulin secretion; insulin sensitivity; Kidney Failure; Knock-out; lipid biosynthesis; loss of function; macrophage; Mammals; Mediating; Medical Economics; Mentors; Metabolic; metabolic profile; Modeling; monocyte; multidisciplinary; Neonatal; Non-Insulin-Dependent Diabetes Mellitus; novel; Obesity; Operative Surgical Procedures; Organ; Overnutrition; Pancreas; Pathogenesis; Peripheral; Phenotype; Physiological; Play; Population; Process; progenitor; Receptor Activation; recruit; relating to nervous system; Resolution; Rodent; Role; Signal Transduction; single molecule; single-cell RNA sequencing; Site; Source; Stromal Cells; Testing; Therapeutic; Thermogenesis; Tissue Expansion; Tissues; tool; Training; transcriptomics; Work; ","Deconstructing the brown neogenic zone in classic brown adipose tissue","116536","ZDK1","Special Emphasis Panel ","","","03","34814","","34814",""
"9896666","F31","NS","5","N","03/23/2020","03/11/2020","03/10/2021","853","F31NS108629","SCHOOLS OF MEDICINE","PA-18-671","5F31NS108629-02","NINDS:32717\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","SAINT LOUIS","UNITED STATES","INTERNAL MEDICINE/MEDICINE","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","Project Narrative Multiple sclerosis (MS) is a major cause of non-traumatic disability among young adults in the United States16; currently, there are no treatments to halt MS progression or induce recovery19. The goal of this proposal is to understand the mechanisms behind immunomodulatory cues that drive chronic disease and translate these findings into novel therapeutic strategies for MS.","12324941; ","MANIVASAGAM, SINDHU ;","UTZ, URSULA","03/11/2019","03/10/2021","Acute; Address; Adoptive Transfer; Affect; Age of Onset; Animals; Antigen-Presenting Cells; Antiviral Agents; Autoimmune Diseases; Autoimmune Process; Autoimmunity; Automobile Driving; autoreactivity; Axon; axon injury; base; Binding; Biological Assay; CD80 gene; Cell Communication; Cells; Cerebrospinal Fluid; Chronic; Chronic Disease; Clinical; CNS autoimmune disease; CNS autoimmunity; Coculture Techniques; Confocal Microscopy; Cues; cytokine; Data; Demyelinating Diseases; Demyelinations; Development; disability; Disease; Disease Progression; Endothelium; Enzyme-Linked Immunosorbent Assay; Exhibits; Experimental Autoimmune Encephalomyelitis; experimental study; Fluorescence Microscopy; Frequencies; Goals; Human; Immune; immune activation; Immune system; Immunohistochemistry; immunoregulation; improved; In Situ Hybridization; In Vitro; Infiltration; Inflammation; Inflammatory; insight; Interferons; Lead; Lesion; Limb structure; Link; Lymphocyte; lymphocyte proliferation; macrophage; Maintenance; Measures; Mediating; member; Modeling; monocyte; mouse model; Multiple Sclerosis; multiple sclerosis patient; multiple sclerosis treatment; Mus; Myelin; Myeloid Cells; Nature; Neuraxis; Neurologic Symptoms; Neurons; novel; novel therapeutic intervention; novel therapeutics; Onset of illness; Optic Neuritis; Pathogenicity; Pathologic; Patients; Peptides; Phenotype; Play; Population; prevent; Prevention; Production; Property; Protein Family; receptor; Recovery; Relapse; Reporter; Resolution; Role; Sampling; Secondary Lesion; Secondary Progressive Multiple Sclerosis; Secondary to; Serum; Severities; side effect; Signal Pathway; Signal Transduction; socioeconomics; Source; spatiotemporal; Spinal Cord Lesions; T-Lymphocyte; Testing; Th1 Cells; Therapeutic; Tissues; Translating; Treatment Efficacy; United States; Viral; young adult; ","TARGETING INTERFERON LAMBDA SIGNALING DURING CENTRAL NERVOUS SYSTEM AUTOIMMUNITY","108629","ZRG1","Special Emphasis Panel ","","","02","32717","","32717",""
"9905301","F31","EY","1","N","02/13/2020","03/01/2020","02/28/2021","867","F31EY031165","SCHOOLS OF MEDICINE","PA-19-195","1F31EY031165-01","NEI:40127\","TRAINING, INDIVIDUAL","2020","NATIONAL EYE INSTITUTE","","SEATTLE","UNITED STATES","BIOCHEMISTRY","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","PROJECT NARRATIVE Aerobic glycolysis is key to maintaining photoreceptor health and function, yet how photoreceptors convert pyruvate to lactate instead of using it to more efficiently make ATP in oxidative phosphorylation is still unknown. A high cytosolic NADH/NAD+ ratio could explain how pyruvate is converted to lactate before it has a chance to be oxidized in mitochondria, but a causative link between a high NADH/NAD+ ratio and aerobic glycolysis has not yet been shown. This project proposes the use of well-validated metabolic flux methods in order to identify how glycolytic retinas but not oxidative tissues maintain a high cytoplasmic NADH/NAD+ ratio, and how photoreceptor metabolism is altered when this ratio is lowered.","14750641; ","BISBACH, CELIA ;","AGARWAL, NEERAJ","03/01/2020","02/28/2023","Address; aerobic glycolysis; Affect; alternative oxidase; Automobile Driving; Blindness; cell type; Cerebellum; Citric Acid Cycle; comparative; Complex; Cultured Cells; Cytosol; Data Collection; Disease; Ecosystem; Etiology; experience; Eye; Genes; Glucose; Glycolysis; Health; human fetal retinal pigment epithelial cell; Investigation; Lead; Link; Malignant Neoplasms; Measurement; Measures; Metabolic; Metabolism; Methods; Mitochondria; Mus; Mutate; NADH; Natural regeneration; Neurons; Oxidative Phosphorylation; Oxides; Photoreceptors; Play; Production; Publishing; Pyruvate; Respiration; Retina; Retinal; Retinal Cone; Role; Source; Structure of retinal pigment epithelium; Testing; Tissues; Vision; Zebrafish; ","Understanding the role of cytosolic NADH production in maintaining aerobic glycolysis in the retina","031165","ZRG1","Special Emphasis Panel ","","","01","40127","","40127",""
"9911649","F31","HD","1","N","12/20/2019","02/01/2020","01/31/2021","865","F31HD101252","SCHOOLS OF ARTS AND SCIENCES","PA-19-195","1F31HD101252-01","NICHD:37073\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","TEMPE","UNITED STATES","OTHER BASIC SCIENCES","09","943360412","US","488301","ARIZONA STATE UNIVERSITY-TEMPE CAMPUS","AZ","852876011","PROJECT NARRATIVE The placenta plays a critical role in healthy pregnancy by regulating nutrition and protecting the fetus from the mother?s immune system. Poor placentation may lead to severe pregnancy complications including preterm birth, intrauterine growth restriction, preeclampsia, and subchorionic hemorrhage, which show a sex difference in incidence. Here, we will characterize gene expression from full-term healthy placentas from male and female offspring and maternal decidua tissue to comprehensively understand the molecular mechanisms of expression in successful pregnancy.","15557758; ","OLNEY, KIMBERLY ;","ILEKIS, JOHN V","02/01/2020","01/31/2022","Alleles; Arizona; Automobile Driving; Biological; Biological Response Modifiers; Cesarean section; Communities; Data; Decidua; Development; differential expression; Disease; Doctor of Philosophy; Down-Regulation; Environment; Equilibrium; exome; Feedback; Female; Fetal Development; Fetal Growth; Fetal Growth Retardation; Fetus; gastrulation; Gene Expression; Gene Expression Regulation; Genes; Genetic; genome-wide; Genomics; Genotype; Goals; gonad development; Growth and Development function; Hand; Health; health difference; healthy pregnancy; Hemorrhage; High Performance Computing; Human; human female; human tissue; Immune; Immune response; Immune system; immunoregulation; Incidence; Inflammation; Inflammatory; Inherited; Innate Immune System; insight; Journals; Knowledge; Lead; Left; Location; male; meetings; Molecular; Mothers; nutrition; offspring; Ovary; Parents; Pathway interactions; Phase; Placenta; Placentation; Play; Pre-Eclampsia; Predisposition; Pregnancy; Pregnancy Complications; pregnancy disorder; Pregnancy Outcome; Premature Birth; programs; Protein Isoforms; Research; Resources; response; Risk; Role; Sampling; sex; Sex Differences; sexual dimorphism; Steroids; Structure; symposium; T cell differentiation; Testing; Tissues; trait; transcriptome; trophoblast; Universities; Uterus; Variant; Vascular remodeling; Work; X Chromosome; XY females; Y Chromosome; ","Characterization of sex differences in human placentas","101252","ZRG1","Special Emphasis Panel ","","","01","37073","","37073",""
"9919017","K43","TW","5","N","03/24/2020","03/01/2020","02/28/2021","989","K43TW011022","","PAR-17-001","5K43TW011022-03","FIC:90317\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","KUMASI","GHANA","","","535154264","GH","10014286","KWAME NKRUMAH UNIVERSITY/SCIENCE/TECH","","0000","Project Narrative This career development plan provides coursework and mentored experiences to acquire additional skills for an independent global health research career. The research project will test the feasibility of implementing Respectful Maternal Care Modules (RMC-M) among midwives to change the culture of disrespect and abuse in maternity care in Kumasi, Ghana. Additionally, it will examine whether exposure to RMC-M increases Ghanaian women?s perception of respectful maternity care in a public hospital setting in Ghana.","15264355; ","DZOMEKU, VERONICA MILLICENT;","LEVINTOVA, MARYA","09/16/2018","02/28/2023","Africa South of the Sahara; antenatal care; Attention; Attitude; base; Behavior; Birth; Brain; career; career development; Caring; Case Study; Child; Childbirth; clinical care; clinical practice; Clinical Practice Patterns; Communication; comparison group; Data; Data Collection; design; Developed Countries; Development Plans; Emergency Situation; Empathy; Evaluation Research; evidence base; experience; Exposure to; Fright; Ghana; global health; Goals; hazard; Health; Health care facility; Healthcare; Home environment; improved; Infant Care; Infrastructure; interactive teaching; Intervention; intervention program; intrapartum; Knowledge; learning strategy; Life; Literature; Live Birth; maltreatment; Maternal and Child Health; Maternal Mortality; meetings; Mentors; Methodology; Michigan; Midwife; mortality; Mothers; neglect; Newborn Infant; North Carolina; obstetric care; Outcome; patient response; Perception; Play; Policies; Positioning Attribute; postnatal; Postpartum Period; Postpartum Women; Practice Guidelines; Pregnancy; Pregnant Women; prenatal; Prenatal care; prevent; Privacy; programs; Public Health; Public Hospitals; Qualitative Methods; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; responsible research conduct; Risk; Role; satisfaction; Schools; Science; Scientist; Secure; senior faculty; skills; Surveys; symposium; Teaching Hospitals; Teaching Method; Techniques; Technology; Temperament; Testing; Time; tool; Training; Translating; Universities; uptake; Verbally abusive behavior; Woman; Work; ","Changing the Culture of Disrespect and Abuse in Maternity Care in Kumasi, Ghana","011022","ICP1","International and Cooperative Projects - 1 Study Section ","","","03","83627","6690","90317",""
"9942064","R25","TW","1","N","03/24/2020","03/26/2020","12/31/2020","989","R25TW011505","","PAR-19-244","1R25TW011505-01","FIC:247318\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","WASHINGTON","UNITED STATES","","98","043990498","US","2863301","GEORGE WASHINGTON UNIVERSITY","DC","200520042","Project Narrative The overall goal of the United States-Mali Research Ethics Training Program (US-Mali RETP) is to strengthen research ethics education and research in Mali through an innovative model of sustainable capacity development to prepare the next generation of ethics researchers. Our approach will be based on close collaboration between George Washington University (GWU) Milken Institute School of Public Health (GWSPH), USA - and University of Science, Techniques & Technologies of Bamako (USTTB), Mali and is aimed at supporting USTTB?s vision of becoming a regional focus for research ethics in French Speaking west Africa. These institutions have a great commitment to understanding the ethical issues around health research, experience and expertise in research and a history of collaborative work and build on their twenty years of experience developing ethics training in Africa and the research environment built at USTTB plus over 25 years of collaboration between USTTB and NIH.","10128727; 7507391 (contact); 11808387; ","DOUMBIA, SEYDOU ; HYDER, ADNAN A (contact); NDEBELE, PAUL ;","SINA, BARBARA J","03/26/2020","12/31/2025","academic program; Address; Africa; Area; base; Bioethics; built environment; burden of illness; Clinical Research; Clinical Trials; Collaborations; Communication; Country; design; Development; Disease; dissemination research; Distance Learning; Ebola virus; education research; Educational Curriculum; Educational process of instructing; Educational workshop; Ensure; Environment; Epidemic; Ethical Issues; Ethics; expectation; experience; Faculty; Funding; Future; Generations; Genetic; genetic approach; Genomics; Goals; Grant; Health; health care delivery; Health Services; Home environment; Human; improved; innovation; Institutes; Institution; Institutional Review Boards; Instruction; International; Knowledge; Lead; Leadership; Learning; Longevity; low income country; Mali; Master of Public Health; Master's Degree; member; Mentors; model development; Modeling; next generation; online course; pedagogy; Policy Research; Program Development; programs; Public Health; Public Health Education; Public Health Schools; Recording of previous events; Research; Research Activity; research and development; Research Ethics; Research Ethics Committees; Research Personnel; Research Priority; Research Support; Research Training; Risk Factors; Science; Teacher Professional Development; technology/technique; Testing; Time; Training; Training Programs; Trust; United States; United States National Institutes of Health; Universities; Vision; Visit; Washington; webinar; Work; ","United States-Mali Research Ethics Training Program (US-Mali RETP)","011505","ZRG1","Special Emphasis Panel ","","","01","235686","11632","247318",""
"9959217","R21","AI","1","N","03/24/2020","03/24/2020","02/28/2021","855","R21AI151987","","PA-19-053","1R21AI151987-01","NIAID:208750\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","","28","075307785","US","1225501","CEDARS-SINAI MEDICAL CENTER","CA","900481804","PROJECT NARRATIVE In this proposal we will investigate the role of the commensal microbiota in promoting antigen- specific memory T cell responses, in both experimental models and humans. We anticipate these studies will contribute for the understanding of the crosstalk between the immune system and the commensal microbiota and can potentially inform for the design of new vaccines.","9600063; ","MARTINS, GISLAINE A.;","ROTHERMEL, ANNETTE L","03/24/2020","02/28/2022","16S ribosomal RNA sequencing; Adoptive Transfer; Antibiotic Therapy; Antibiotics; Antigens; Area; Bacteria; Cell physiology; cell type; Cells; cohort; commensal microbes; Complex; Confocal Microscopy; cytokine; Data; design; Development; dysbiosis; Epithelial; Experimental Models; experimental study; Flow Cytometry; fungus; Gastrointestinal tract structure; Gene Expression; Gene Expression Profiling; germ free condition; Germ-Free; gut microbiota; Human; human subject; Immune; Immune response; Immune system; Immune System Diseases; immune system function; Immunity; Immunization; immunoregulation; Impairment; improved; in vivo; Individual; Infection; Influenza; Interleukin-15; Intestines; Lamina Propria; Light; Lung; Lymphoid; Lymphoid Tissue; Maintenance; Memory; memory CD4 T lymphocyte; Memory impairment; microbiota; microorganism; mouse model; Mucous Membrane; Mus; novel therapeutic intervention; novel vaccines; Oral Administration; Organ; peripheral blood; Physiology; Play; Predisposition; Production; reconstitution; Reporter; response; Role; Sampling; Shapes; Signal Transduction; Source; Stains; Stromal Cells; Surface; System; Systems Development; T cell response; T memory cell; T-Lymphocyte; Testing; Training; transcriptome sequencing; Vaccination; Vaccines; Yellow Fever; Yellow fever virus; ","Investigating the requirement of the commensal microbiota for long term T cell immunity","151987","CMIB","Cellular and Molecular Immunology - B Study Section ","","","01","125000","83750","208750",""
"9970979","R01","AI","1","N","03/23/2020","03/25/2020","02/28/2021","855","R01AI146031","SCHOOLS OF MEDICINE","PA-19-056","1R01AI146031-01A1","NIAID:548492\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","MINNEAPOLIS","UNITED STATES","INTERNAL MEDICINE/MEDICINE","05","555917996","US","1450402","UNIVERSITY OF MINNESOTA","MN","554552070","Project Narrative Malaria is still a major cause of death partially because we do not understand how antibodies protect. We recently found that natural killer (NK) cells could kill infected RBCs via antibody mediated cellular cytotoxicity (ADCC), and in an endemic malaria cohort, specific NK cells enhanced for ADCC activity correlated with decreased parasitemia and protection from malaria. This proposal builds on our findings to understand how these specific NK cells form and function, as well as understand how antibodies function to protect humans from malaria with the hope to improve vaccine design and efficacy readouts.","14941858; ","HART, GEOFFREY T;","MO, ANNIE X Y","03/25/2020","02/28/2025","Ablation; Adherence; Adhesions; Affect; Antibodies; Antibody Response; antibody-dependent cell cytotoxicity; Antibody-Dependent Enhancement; Antibody-mediated protection; Apoptosis; base; Binding; Biological Assay; Cause of Death; CD3 Antigens; Cell Adhesion Molecules; Cell Nucleus; Cell-Mediated Cytolysis; Cessation of life; child bearing; Chondroitin Sulfate A; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; cohort; CRISPR/Cas technology; cytokine; Cytokine Signaling; Data; design; Development; Effector Cell; Engineering; Fc Receptor; FCGR3B gene; Frequencies; Future; granulysin; Granzyme; Growth; Human; human monoclonal antibodies; Immunization; Immunize; Immunotherapy; improved; In Vitro; Individual; Infection; insight; Label; Lead; Malaria; malaria infection; Malaria Vaccines; Mediating; Membrane Proteins; men; Monkeys; Monoclonal Antibodies; Natural Killer Cells; Nature; Necrosis; Nitric Oxide; novel; Parasitemia; Parasites; perforin; Placenta; placental malaria; Plasma; Plasmodium; Pregnancy; Pregnancy Outcome; programs; Protein Isoforms; Proteins; response; Role; Sampling; Signal Transduction; Spontaneous abortion; Surface; System; T-Lymphocyte; Testing; Therapeutic; Therapeutic antibodies; tool; transcription factor; Vaccination; Vaccine Design; vaccine efficacy; Vaccines; Woman; ZAP-70 Gene; ZNF145 gene; ","The role of natural killer cells and antibodies in protection from malaria","146031","IHD","Immunity and Host Defense ","","A1","01","366620","181872","548492",""
"9973847","R01","AI","1","N","03/24/2020","03/24/2020","02/28/2021","855","R01AI143694","SCHOOLS OF MEDICINE","PA-19-056","1R01AI143694-01A1","NIAID:774283\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CLEVELAND","UNITED STATES","OTHER HEALTH PROFESSIONS","11","077758407","US","218601","CASE WESTERN RESERVE UNIVERSITY","OH","441061712","Our proposal's goal is to develop new approaches for the prevention and treatment of human malaria caused by Plasmodium vivax (P. vivax). This type of malaria, known as vivax malaria, is the most widely distributed type of malaria with 3.3 billion people at risk and at least 15 million clinical cases worldwide each year. The proposal aims to isolate and produce monoclonal antibodies that recognize molecules essential for the parasite to infected liver and red blood cells from individuals who have become immune to vivax malaria. The production and characterization of these human monoclonal antibodies will help in the design and development of vaccines against vivax malaria and provide novel therapeutics to both prevent and treat individuals at risk or infected with this parasite.","1877985; ","KING, CHRISTOPHER L;","PESCE, JOHN T","03/24/2020","02/28/2025","Address; Adjuvant; Adult; Affinity; Africa South of the Sahara; Amino Acid Sequence; Antibodies; Antigens; apical membrane; Area; B-Lymphocytes; Binding Proteins; Biological Assay; Biomass; Blood; Brazil; Cambodia; Cells; Cessation of life; Child; Chimeric Proteins; Chronic; circumsporozoite protein; Clinical; Clone Cells; Complement; Copy Number Polymorphism; Data; design; Development; disorder risk; Drug resistance; Epitopes; Erythrocytes; Ethiopia; Event; experimental study; Exposure to; Fever; Gene Dosage; Genetic Polymorphism; Geography; Goals; Health Policy; Hepatic; Hepatocyte; Human; human monoclonal antibodies; Immune; Immune Sera; Immunity; Immunize; Immunoglobulin G; Immunologist; In Vitro; in vitro Assay; in vivo; Individual; Infection; Infection prevention; Injections; innovation; Knowledge; Liver; Longitudinal cohort; Lymphocyte; Malaria; Malaria Vaccines; Measures; Mediating; migration; Monoclonal Antibodies; Morbidity - disease rate; mouse model; neutralizing monoclonal antibodies; next generation; novel strategies; novel therapeutics; novel vaccines; Papua New Guinea; parasite invasion; Parasites; Patients; Plasmodium falciparum; Plasmodium vivax; Plasmodium vivax vaccine; Play; Population; Population Heterogeneity; prevent; Prevention; Prevention approach; Primary Infection; Production; Proteins; Public Health; receptor; receptor binding; Relapse; Residual state; Reticulocytes; Risk; Role; sample fixation; Solomon Islands; Sporozoites; Structure; Syndrome; Technology; Time; Transcend; Transgenic Organisms; transmission process; vaccine development; vaccine-induced immunity; Vaccines; Vivax Malaria; Work; ","Defining targets of protective immunity to vivax malaria using human monoclonal antibodies","143694","CRFS","Clinical Research and Field Studies of Infectious Diseases Study Section ","","A1","01","510066","264217","774283",""
"9986027","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007590","","RFA-MD-18-012","5U54MD007590-33","NIMHD:214762\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","ATLANTA","UNITED STATES","","05","065325177","US","2189101","CLARK ATLANTA UNIVERSITY","GA","303144358","Project Narrative In the first aim, we propose a concept that prostate cancer patients, particularly Black men (African American (AA), Caribbean, or African), may express higher HMGA2 wild-type and truncated isoforms. In the second aim we plan to examine the correlation between HMGA2 single nucleotide polymorphisms that more prevalent in Black men and prostate cancer incidence, while in the third aim, we will explore the mechanism(s) by which HMGA2 mediates cancer-bone interactions. Using the following proposed aims we hope to determine the importance of HMGA2 in prostate health disparities and prostate cancer bone metastasis.","8630420; ","ODERO-MARAH, VALERIE ;","","","","3' Untranslated Regions; Affect; African; African American; Alternative Splicing; alternative treatment; anticancer research; bone; bone cell; Bone Density; Bone neoplasms; Calcium; cancer cell; Cancer Patient; Caribbean region; caucasian American; Caucasians; cell motility; Cells; Cessation of life; Chromatin; Chromosomal Rearrangement; Clinical; Coculture Techniques; Data; density; Diagnosis; Disease; Epithelial; Genotype; health disparity; High Mobility Group Proteins; Hormones; Hydroxyapatites; Implant; In Vitro; in vivo; Incidence; Lead; Length; LNCaP; Malignant Bone Neoplasm; Malignant neoplasm of cervix uteri; Malignant neoplasm of prostate; Malignant Neoplasms; Mediating; men; Mesenchymal; Metastatic Neoplasm to the Bone; Metastatic Prostate Cancer; Minerals; Molecular; mortality; mouse model; Neoplasm Metastasis; novel; Nuclear; older men; overexpression; paracrine; Patients; Prostate; prostate cancer cell; prostate cancer metastasis; prostate cancer progression; Protein Isoforms; Proteins; Race; Reactive Oxygen Species; Refractory; Risk; Role; Sampling; Signal Transduction; Single Nucleotide Polymorphism; small molecule inhibitor; Testing; Time; Tissues; Tobago; Trinidad; Universities; Uterine Cancer; Variant; ","Role of High Mobility Group A2 (HMGA2) in Prostate Cancer","007590","ZMD1","Special Emphasis Panel ","8343","","33","139500","75330","","214762"
"9991479","F31","HD","1","N","03/03/2020","03/26/2020","03/25/2021","865","F31HD102155","SCHOOLS OF MEDICINE","PA-19-195","1F31HD102155-01","NICHD:37885\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","DAVIS","UNITED STATES","PSYCHIATRY","03","047120084","US","577503","UNIVERSITY OF CALIFORNIA AT DAVIS","CA","956186153","PROJECT NARRATIVE This study compares the parent-child interactions for parents of children with autism spectrum disorder (ASD) who received coaching in positive behavior support strategies and those coached in a manualized naturalistic developmental behavioral intervention (NDBI), the Parent Early Start Denver Model (P-ESDM) as part of a larger study in which children received intensive, therapist-implement treatment using either a structured behavioral strategy, Discrete Trial Teaching (DTT) or Early Start Denver Model (ESDM). To our knowledge, no studies have compared parent implementation of structured behavioral and NDBI interventions despite the fact that the two approaches differ in the strategies they use to improve parent-child interactions. Measuring the active ingredients across intervention approaches may lead to a greater understanding of how best to support parents of children with ASD.","15900518; ","VEJNOSKA, SARAH ;","KAU, ALICE S","03/26/2020","03/25/2022","Adult; Affect; Affective; Aftercare; applied behavior analysis; Attention; autism spectrum disorder; autistic children; base; Behavior; Behavior Therapy; Behavioral; Caregivers; Child; Child Development; Child Rearing; Child Support; Code; Collaborations; Communication Research; Communities; Coupled; Cues; Data; Data Analyses; design; Development; early childhood; Early Intervention; Education; Educational Intervention; Educational process of instructing; Environment; Evidence based intervention; Evidence based practice; Exceptional Child; Fellowship; Frequencies; Goals; Grant; Home environment; improved; Intervention; intervention effect; Intervention Studies; Lead; Learning; Learning Disorders; Link; Measurement; Measures; Mediating; Methodology; Methods; Modeling; National Research Council; Outcome; Parent-Child Relations; parental role; Parents; Play; Provider; Psychology; Research; Research Infrastructure; Research Project Grants; Research Support; Role; Science; skills; Structure; Toddler; Toy; Training; treatment strategy; Video Recording; ","An examination of the role of parental sensitivity and responsivity and learning opportunities in parent-mediated intervention for toddlers with autism spectrum disorder","102155","ZRG1","Special Emphasis Panel ","","","01","37885","","37885",""
"9994521","R13","NS","1","N","03/23/2020","03/20/2020","02/28/2021","853","R13NS117006","SCHOOLS OF MEDICINE","PA-18-648","1R13NS117006-01","NINDS:15000\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","DALLAS","UNITED STATES","PEDIATRICS","30","800771545","US","578404","UT SOUTHWESTERN MEDICAL CENTER","TX","753909105","Project Narrative SLC13A5 Deficiency is a devastating epileptic encephalopathy with no disease-modifying treatments currently available. We propose our 4th International SLC13A5 Deficiency Research Roundtable to bring together families, clinicians and scientists with diverse expertise. It is anticipated that this conference will build upon the clinical and scientific gaps identified at our previous Research Roundtable and enable researchers to develop translational research programs and clinical trial readiness based on knowledge gained.","10311114; ","BAILEY, RACHEL M;","WHITTEMORE, VICKY R","03/20/2020","02/28/2021","Address; Affect; Aging; Area; authority; Award; base; bench to bedside; Biology; boys; Brain; Cells; Child; Childhood; citrate carrier; Citrates; Clinical; Clinical Trials; Collaborations; Communities; Consensus; Data; Dentistry; Development; Developmental Delay Disorders; Diabetes Mellitus; Diagnosis; Disease; Doctor of Philosophy; Drug resistance; effective therapy; Energy Metabolism; Epilepsy; epileptic encephalopathies; Ethnic Origin; Faculty; Family; Foundations; Funding; gene therapy; Gene therapy trial; Gene Transduction Agent; Genes; Genetic; girls; Goals; graduate student; Health Professional; induced pluripotent stem cell; Industry; innovation; interest; International; Knowledge; Life; Lighting; Liver; Location; Longevity; loss of function mutation; Medical center; meetings; member; Metabolic; Minority Groups; Monitor; Mothers; Motor; mouse model; Movement Disorders; multidisciplinary; nervous system disorder; Neurology; Neurons; Non-Insulin-Dependent Diabetes Mellitus; Nonprofit Organizations; novel; Pathogenesis; Pathology; patient population; Patients; pediatric department; Pediatric Neurology; preclinical development; Production; programs; Race; Readiness; Reporting; Research; Research Personnel; Research Priority; Resistance; Resources; Role; Scientist; Seizures; SLC13A5 deficiency; Sodium; Speech; symposium; Texas; therapeutic development; therapy development; Translating; Translational Research; translational research program; Translations; Travel; Underrepresented Minority; Universities; vector; Viral; Walking; Work; ","4th International SLC13A5 Deficiency Research Roundtable","117006","ZNS1","Special Emphasis Panel ","","","01","15000","0","15000",""
"10013957","R01","AI","1","N","03/25/2020","03/25/2020","02/28/2021","855","R01AI150381","","PA-19-056","1R01AI150381-01A1","NIAID:443750\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LA JOLLA","UNITED STATES","","49","781613492","US","7375802","SCRIPPS RESEARCH INSTITUTE","CA","920371000","PROJECT NARRATIVE  As a novel approach to the treatment of HIV, this proposal seeks to provide a solution to eventually eliminate the pool of cells harboring latent virus. We will express surface-bound and soluble broadly- neutralizing antibodies targeting HIV that are highly effective against a diverse range of HIV strains. As the surface-bound antibodies recognize viral proteins on infected cells, this recognition will lead to its killing, while soluble antibodies neutralize free virus.","8871482; ","LAWSON, BRIAN RANDOLPH;","POON, BETTY","03/25/2020","02/28/2025","Address; Adverse event; Affinity; Anti-Retroviral Agents; Antibodies; Antigens; antiretroviral therapy; Autologous; Binding; Binding Sites; Biological Assay; CD8-Positive T-Lymphocytes; cell killing; Cell Line; Cells; cellular transduction; Chemicals; chimeric antigen receptor; chimeric antigen receptor T cells; Chronic; combat; density; design; Disease Progression; engineered T cells; Evaluation; Future; Generations; Goals; HIV; HIV Infections; Human; humanized mouse; Immunotherapeutic agent; Immunotherapy; improved; In Vitro; in vivo; in vivo evaluation; Individual; Infection; innovation; insight; Life; Link; Membrane; Methods; Modality; Modeling; mouse model; Mus; Nature; neutralizing antibody; nonhuman primate; novel; novel strategies; pathogen; Patients; Process; prophylactic; Proviruses; Route; Scanning; Serum; Signal Transduction; simian human immunodeficiency virus; Surface; synergism; T-Lymphocyte; Testing; Therapeutic; Toxic effect; vector; Viral; Viral Load result; Viral Proteins; Viral reservoir; virtual; Virus; Virus Latency; ","CAR T CELLS ENGINEERED TO KILL HIV-INFECTED CELLS WHILE SECRETING BROADLY NEUTRALIZING ANTIBODIES","150381","HIVD","HIV Immunopathogenesis and Vaccine Development Study Section ","","A1","01","250000","193750","443750",""
"10055833","R01","NS","3","N","03/24/2020","01/01/2020","07/31/2020","853","R01NS107398","SCHOOLS OF MEDICINE","PA-18-906","3R01NS107398-01A1S1","NINDS:40577\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","DAYTON","UNITED STATES","OTHER BASIC SCIENCES","07","047814256","US","253101","WRIGHT STATE UNIVERSITY","OH","454350001","Project Narrative Disruption of the axon initial segment in neurons is associated with cognitive impairment in type 2 diabetes, in which the glucose metabolite methylglyoxal is elevated. This diversity supplement application together with the parent R01 grant will elucidate the mechanisms of how methylglyoxal affects axon initial segment and neuronal function by identifying a critical cellular mechanism involved in this process. The proposed research is relevant to public health because it is expected to provide critical knowledge of nervous system pathophysiology needed to establishing novel treatments for cognitive impairment while training a future physician scientist to diversify the research field.","12239236; ","SUSUKI, KEIICHIRO ;","MORRIS, JILL A","01/01/2020","07/31/2022","Action Potentials; Address; Affect; African American; Alzheimer's Disease; Applications Grants; Axon; Behavior; Biological Assay; Brain; Butyric Acids; Calcium; Calpain; career; career development; Caspase; Cell Death; Cell Survival; Characteristics; Clinic; Clinical; Cognition Disorders; Cognitive deficits; Communities; Comorbidity; Coupled; cytotoxicity; Data; Data Analyses; db/db mouse; Diabetes Mellitus; diabetic; Disease; doctoral student; Endoplasmic Reticulum; endoplasmic reticulum stress; experience; Exposure to; Fellowship; Female; Functional disorder; Future; Genes; Glucose; glucose metabolism; Goals; Grant; GRP78 gene; Hippocampus (Brain); Hour; Immunofluorescence Immunologic; Impaired cognition; inhibitor/antagonist; innovation; Knowledge; Lead; Length; Life; Measures; Mediating; Mediator of activation protein; Mentors; Modeling; Molecular; multi-electrode arrays; Mus; National Institute of Neurological Disorders and Stroke; National Research Service Awards; Nerve Degeneration; Nervous System Physiology; Nervous system structure; network dysfunction; neural network; Neurodegenerative Disorders; Neurologic; Neuronal Dysfunction; neuronal excitability; Neurons; Non-Insulin-Dependent Diabetes Mellitus; novel; parent grant; Parents; Patients; Pharmaceutical Preparations; Physicians; Positioning Attribute; prevent; Process; protein complex; Proteins; Public Health; Pyruvaldehyde; Research; Research Design; Research Personnel; Resources; response; Scientist; Structure; Study Skills; success; Synaptic Transmission; Techniques; Testing; Training; Translational Research; Tunicamycin; Western Blotting; Woman; Work; ","ER stress mediates methylglyoxal-evoked AIS shortening and neuronal dysfunction","107398","","","","A1S1","01","31817","8760","40577",""
"10068227","R21","AI","7","N","03/23/2020","03/01/2020","02/28/2021","855","R21AI144916","","PA-18-590","7R21AI144916-02","NIAID:218850\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","MENANDS","UNITED STATES","","20","153695478","US","5966012","WADSWORTH CENTER","NY","122042726","Project Narrative The studies proposed in this application are aimed at delineating how specific host genetic polymorphisms elicits the type of inflammatory immune responses that lead to the development of disadvantageous clinical outcomes in Lyme disease. We believe that our multiprong approach, which is based in a human system and utilizes tissue, cells, and clinical information from exceptionally well-defined patients, coupled with the latest systems-based methods, will generate important new insight into the pathogenesis of Lyme disease from initial infection to post-treatment complications. These findings will help lay the groundwork for new diagnostic approaches and more rational and effective treatment strategies for patients with severe disease.","9348150; ","STRLE, KLEMEN ;","ILIAS, MALIHA R","12/10/2019","02/28/2021","acute infection; adverse outcome; Affect; Aftercare; Agonist; Antibiotic Therapy; Antibiotics; Arthritis; autoreactive T cell; B-Lymphocytes; base; Biological Markers; Biological Models; Borrelia burgdorferi; Caucasians; Cell Culture Techniques; Cell surface; Cells; Chronic; Clinical; cohort; Combined Antibiotics; Communities; Complication; Coupled; cytokine; Development; diagnostic assay; Disease; effective therapy; Epidemic; erythema migrans; experimental study; Fatigue; Frequencies; Gene Family; Genes; Genetic; Genetic Polymorphism; genetic risk factor; genome wide association study; Grant; Human; human disease; Immune; Immune response; Immunity; Immunology; Immunotherapy; Impairment; Infection; Inflammation; Inflammatory; insight; interest; Interferons; Interleukin-10; interleukin-23; Investigation; Knowledge; Lead; Link; Location; Lyme Arthritis; Lyme Disease; lyme pathogenesis; Mediator of activation protein; Methodology; Methods; microbial; Microbial Genetics; microbial host; Modeling; Molecular; Neurocognitive; New England; novel; novel diagnostics; Order Spirochaetales; Other Genetics; Outcome; Pain; Pathogenesis; Pathogenicity; Patients; Phenotype; Physicians; Play; Production; Psoriasis; Psoriatic Arthritis; Refractory; Regulatory Pathway; response; Risk; Risk Factors; risk variant; RNA Interference; Role; Sampling; Serum; Severities; Severity of illness; Signal Transduction; Single Nucleotide Polymorphism; Susceptibility Gene; Symptoms; Syndrome; Synovial Fluid; Synovitis; System; Techniques; tick borne spirochete; Tissues; TLR1 gene; transcriptome; transcriptome sequencing; translational approach; treatment strategy; Variant; Work; ","Defining host genetic factors in adverse clinical outcomes in Lyme disease","144916","ZRG1","Special Emphasis Panel ","","","02","173520","45330","218850",""
"10071680","R01","MD","7","N","03/23/2020","03/23/2020","02/28/2021","307","R01MD009708","","PA-18-590","7R01MD009708-05","NIMHD:377171\","Non-SBIR/STTR RPGs","2019","National Institute on Minority Health and Health Disparities","","ALBUQUERQUE","UNITED STATES","","01","098640696","US","10003182","THE MIND RESEARCH NETWORK","NM","871063834","PUBLIC HEALTH RELEVANCE: Hispanic youth generally, and adjudicated Hispanic youth in particular, suffer from higher rates of lifetime and current alcohol and cannabis use than do non-Hispanic youth, and do not benefit as much from addiction treatment. Some of this health disparity may be due to differences in the ways that substance use clinicians interact with Hispanic vs. non-Hispanic clients during treatment sessions. Investigating these within-session behaviors and communication patterns in an existing sample of 506 recorded treatment sessions may help us to modify existing treatments so that they are more effective with Hispanic youth, which could potentially translate into substantial savings in public health dollars.","9283176; ","HOUCK, JON M.;","STINSON, NATHANIEL","07/01/2016","02/28/2021","","Improving adolescent health by assessing in-session communication patterns","009708","HDEP","Health Disparities and Equity Promotion Study Section ","","","05","268913","108258","377171",""
"10079514","U54","MD","3","N","03/23/2020","09/01/2019","08/31/2020","","U54MD000214","","PA-18-906","3U54MD000214-18S1","NIMHD:41666\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","BALTIMORE","UNITED STATES","","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","","6374004; ","GASKIN, DARRELL J.;","SAYRE, MICHAEL","09/22/2002","04/30/2022","","HCHDS Administrative Core","000214","","","6974","S1","18","25445","16221","","41666"
"10087165","R00","EY","4","N","03/24/2020","03/01/2020","02/28/2021","867","R00EY028625","BIOMED ENGR/COL ENGR/ENGR STA","PA-16-193","4R00EY028625-03","NEI:249000\","Non-SBIR/STTR RPGs","2020","NATIONAL EYE INSTITUTE","","BERKELEY","UNITED STATES","ENGINEERING (ALL TYPES)","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947101749","NARRATIVE The central nervous system (CNS) is made up of a large diversity of neuronal types, a major proportion of which remain to be identified and defined in terms of molecular markers so that their roles in function and dysfunction can be assessed. This project seeks to combine high-throughput single-cell transcriptomics, innovative computational and histological methods to comprehensively define neuronal heterogeneity in an accessible system ? the mouse retina, and use this as a foundation to (1) initiate a similar mapping of the macaque retina, and (2) study cell-type specific responses in a tractable model of nerve injury (optic nerve crush) to map the resilience of different cell types, and identify molecular correlates underlying these differences. Our work will create transformational tools to address similar challenges in other CNS regions.","12610716; ","SHEKHAR, KARTHIK ;","LIBERMAN, ELLEN S","03/01/2018","02/28/2023","Address; Amacrine Cells; Animal Model; Axon; base; Behavioral; Brain; Brain region; Cell Communication; cell type; Cells; Censuses; central nervous system injury; Cerebral cortex; Cessation of life; Complex; Computer Analysis; Computing Methodologies; Custom; Data; Data Analyses; design; Disease; Event; Felis catus; Foundations; Functional disorder; ganglion cell; Gene Expression; Genetic; Genetic Transcription; Genomics; Glaucoma; Goals; Growth; Heterogeneity; Histologic; Histology; Human; human model; Immune; in vivo; Individual; Inflammation; injured; Injury; innovation; Intervention; Intervention Studies; Investigation; knock-down; Label; Learning; Location; Macaca; Machine Learning; Maps; Measurement; Mediating; Methods; Minority; Modeling; Molecular; Molecular Genetics; molecular marker; Molecular Profiling; Morphology; Mus; Natural regeneration; Nerve Crush; nerve injury; Neuraxis; Neurons; neuroprotection; Neurosciences; novel marker; Optic Nerve; Optic Nerve Injuries; Pattern; Physiological; Physiology; Plant Roots; programs; Recovery of Function; relating to nervous system; Reporting; resilience; Resources; response; Retina; Retinal; retinal ganglion cell regeneration; Retinal Ganglion Cells; retinal neuron; Role; single-cell RNA sequencing; Stroke; stroke-like episode; Structure; Surveys; Survival Rate; System; Taxonomy; Technology; Therapeutic; Therapeutic Intervention; Tissues; tool; transcriptomics; Tumor-infiltrating immune cells; Vertebrates; Vision; Visual; Work; ","Uncovering the molecular identity of retinal cell types, and their responses to nerve injury using single-cell transcriptomics","028625","NSS","Special Emphasis Panel ","","","03","201474","47526","249000",""
"10128572","R25","DK","3","N","03/24/2020","04/01/2019","03/31/2020","847","R25DK096999","","PAR-15-138","3R25DK096999-08S1","NIDDK:19440\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","There is a critical national need for educational innovations that recruit undergraduate students to pursue STEM (science, technology, engineering, mathematics) disciplines that fill the pipeline with scientists who conduct research in areas relevant to the NIH mission, and, in particular, that of NIDDK. In this renewal, we propose to leverage our success in recruiting, preparing and increasing the numbers of diverse undergraduate students that pursue STEM careers relevant to the NIDDK mission. Additionally, we will implement several innovations, piloted over the previous funding cycle, to perfect a holistic model of research experiences augmented with professional skills development and guided self-discovery. .","1866004; ","HUDSON, BILLY GERALD;","RANKIN, TRACY L","09/30/2012","03/31/2023","Academic Medical Centers; Address; American; American Indians; Area; Award; Biology; Cancer Education Grant Program; Data; Dental Schools; Development; Disease; Economically Deprived Population; Educational Background; Engineering; Ethnic group; ethnic minority population; experience; Family; Funding; Geography; Goals; Graduate Degree; Grant; guided inquiry; holistic approach; Individual; innovation; K-12 student; Kidney; mathematical ability; Mathematics; Medical; Mentors; Minority Groups; Mission; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; novel; Outcome; Outcomes Research; Participant; programs; Publications; Race; racial minority; Recovery; recruit; Research; Schools; Science; Scientist; skill acquisition; skills; stem; STEM career; STEM field; Students; success; Technology; Training; undergraduate student; United States National Institutes of Health; ","Aspirnaut Undergraduate Discovery Science Experience in Renal Biology and Disease","096999","DDK","Kidney, Urologic and Hematologic Diseases D Subcommittee ","","S1","08","18000","1440","19440",""
"10129115","R01","DA","7","N","03/26/2020","01/01/2020","07/31/2020","279","R01DA043162","SCHOOLS OF MEDICINE","PA-18-590","7R01DA043162-05","NIDA:575693\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE ON DRUG ABUSE","","NORTH CHICAGO","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","10","069501252","US","1402201","ROSALIND FRANKLIN UNIV OF MEDICINE & SCI","IL","600643037","PROJECT NARRATIVE HIV-1 infection and abuse of drugs such as cocaine often cause a number of brain diseases and affect the ability of people to care for themselves and thus the quality of their daily life. The social and economic impact cannot be overemphasized. The current study seeks to have a better understanding of how HIV and drug abuse interact in the era of combination antiviral therapy and then use the knowledge acquired to develop new markers to monitor the disease progression and treatment response and develop new therapeutics.","2089992; ","HE, JOHNNY J;","LIN, YU","01/01/2020","07/31/2021","","HIV Infection and Latency In Astrocytes","043162","ZDA1","Special Emphasis Panel ","","","05","369034","206659","575693",""
"10131908","U43","DA","3","N","03/24/2020","09/30/2018","09/30/2020","279","U43DA046148","","RFA-DA-18-010","3U43DA046148-01S1","NIDA:75000\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","SAN FRANCISCO","UNITED STATES","","12","065461750","US","10047212","SPIRE, INC.","CA","941101310","PROJECT NARRATIVE The ability of an addict to recover from substance abuse disorders is greatly impacted by the cognitive and emotional state of the individual, and learning new thought and behavioral patterns can facilitate successful treatment and recovery. This project will test the ability of a clothing-adhered smart device, the Spire Health Tag, to help drug addicts manage the stress and anxiety that influences cravings by monitoring their physiological patterns and issuing real-time feedback and prompts to trigger the behavioral change that improves stress and anxiety management.","15174553; ","MORAVEJI, NEEMA MORTAZAVI;","HAMPSON, AIDAN","09/30/2018","09/30/2020","Adherence; Adhesives; Anxiety; anxiety management; Apple; Awareness; base; Behavior Therapy; Behavioral; Biological Markers; Clinical; Clothing; Cognitive; Cognitive Therapy; Complement; cost; craving; design; Devices; Disease; drug addict; Drug usage; emotion regulation; Emotional; Feedback; Goals; Health; improved; Incidence; Individual; Intervention; Lead; Learning; Measurable; Monitor; National Institute of Drug Abuse; novel; Patients; Pattern; Phase; Physiological; Pilot Projects; Population; Productivity; programs; prototype; Quality of life; Recovery; Relapse; Research; Research Personnel; respiratory; smartphone Application; Stress; stress management; Substance abuse problem; Substance Use Disorder; Technology; Testing; Time; tool; wearable device; ","A Clothing-Adhered Wearable to Monitor Biomarkers of Cognitive/Emotional State and Deliver Just-in-Time Behavioral Interventions","046148","ZDA1","Special Emphasis Panel ","","S1","01","","","75000",""
"9883053","R01","MH","5","N","03/27/2020","03/01/2020","02/28/2021","242","R01MH108555","","PAR-13-055","5R01MH108555-05","NIMH:705232\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PHILADELPHIA","UNITED STATES","","03","073757627","US","1499101","CHILDREN'S HOSP OF PHILADELPHIA","PA","191462305","PUBLIC HEALTH RELEVANCE: Demonstrating that (a) agency therapists and supervisors who have had little to no prior exposure to EBPs can implement an anxiety disorders EBP with fidelity, (b) a shorter and culturally sensitive version of a treatment for anxiety is at least as effective as the original version, and (c) determining which of two implementation strategies for therapists (internal supervision with or without consultation for supervisors) will lead to better outcomes, should encourage wider spread adoption of EBPs for anxiety disorders in under-served school children.","6714222; ","EIRALDI, RICARDO B;","PINTELLO, DENISE","06/15/2016","02/28/2021","Address; Adoption; Aftercare; Anxiety; Anxiety Disorders; anxiety treatment; arm; Behavioral; behavioral health; Characteristics; Child; child services; Cities; Clinical; cloud based; Cognitive Therapy; Communities; community setting; comparative cost effectiveness; Competence; Consultations; contextual factors; Contracts; cost; Cost Analysis; cost effective; cost effectiveness; Counseling; design; Diagnostic; dissemination research; Effectiveness; Emotional; evidence base; Evidence based practice; Exposure to; Friends; Funding; Health; Health Insurance Portability and Accountability Act; Hybrids; Impairment; implementation research; implementation strategy; implementation trial; improved; interdisciplinary collaboration; Intervention; Learning; Life; Link; Low income; Measures; Mediating; Mediator of activation protein; Medicaid; Mental Health; Mental Health Services; mental training; National Institute of Mental Health; Nonprofit Organizations; Outcome; Philadelphia; Population; Procedures; Process; Program Development; Protocols documentation; Provider; psychosocial; public health relevance; Randomized; Research; Resources; school district; Schools; Services; Severities; Social Problems; Strategic Planning; Stress; Supervision; Symptoms; System; Testing; Trainers Training; Training; Training Support; Treatment Effectiveness; treatment group; Treatment Protocols; urban school; Work; ","A Hybrid Effectiveness-Implementation Trial of Group CBT in Urban Schools","108555","DIRH","Dissemination and Implementation Research in Health Study Section ","","","05","440263","264969","705232",""
"9883768","K99","DA","5","N","03/25/2020","03/01/2020","02/28/2021","279","K99DA045765","OVERALL MEDICAL","PA-18-398","5K99DA045765-02","NIDA:193796\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","PISCATAWAY","UNITED STATES","NONE","06","078795875","US","10034170","RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL","NJ","088548021","PROJECT NARRATIVE The orexin (hypocretin) system has been identified as a promising target for pharmacotherapies designed to treat addiction. The proposed research will examine how the orexin system interacts with stress and reward circuits in the brain, and how these systems are changed in addiction. This knowledge will facilitate the development of orexin-based therapies that can effectively treat the multifaceted symptoms associated with addiction.","12179318; ","JAMES, MORGAN ;","SORENSEN, ROGER","03/01/2019","02/28/2021","Acute; addiction; Animals; Anxiety; anxiety-like behavior; associated symptom; Automobile Driving; Award; base; Behavior; Behavioral; behavioral economics; Brain; career; Cells; Chronic; Cocaine; Cocaine Dependence; Contralateral; Data; design; designer receptors exclusively activated by designer drugs; Development; Dopamine; dopaminergic neuron; Down-Regulation; drug seeking behavior; Drug usage; drug withdrawal; Electrophysiology (science); Exhibits; experimental study; Exposure to; Future; Grant; Human; hypocretin; Hypothalamic structure; Infusion procedures; Knowledge; Learning; Measures; Medial; Mediating; Mediator of activation protein; Mentors; Mentorship; Microinjections; Modeling; Motivation; multiple drug use; negative emotional state; Negative Reinforcements; Neurons; Neuropeptides; Neurosciences; novel; Nucleus Accumbens; optogenetics; orexin 1 receptor; Pathway interactions; Pattern; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Phase; Phenotype; Population; Prefrontal Cortex; Process; Rattus; Recording of previous events; Relapse; Reporting; Research; Rewards; Role; SB-334867; Scientist; Self Administration; Signal Transduction; Site; Stress; Symptoms; System; Techniques; Testing; Training; Treatment Efficacy; Ventral Tegmental Area; Viral; Viral Vector; Withdrawal; withdrawal-induced anxiety; Work; ","Orexin/hypocretin as a common mediator of stress and reward behavior in cocaine addiction","045765","ZDA1","Special Emphasis Panel ","","","02","179441","14355","193796",""
"9888209","R21","EB","5","N","03/25/2020","02/01/2020","01/31/2021","286","R21EB026012","SCHOOLS OF MEDICINE","PAR-16-390","5R21EB026012-03","NIBIB:157091\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","SAN FRANCISCO","UNITED STATES","RADIATION-DIAGNOSTIC/ONCOLOGY","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","PROJECT NARRATIVE In this proposal, we describe a method for predicting the presence of aggressive prostate cancer and subsequent disease progression using a recently developed method for high signal to noise ratio hyperpolarized 13C imaging of interstitial pH using 13C bicarbonate produced by polarization of a precursor molecule, glycerol carbonate. A plan for optimization of the technique and suitable quality control measures are proposed for subsequent FDA IND submission. This method could be incorporated in prostate magnetic resonance imaging protocols and could find immediate use in initial staging of prostate cancer.","7258963; ","FLAVELL, ROBERT RICHARD;","WANG, SHUMIN","05/01/2018","01/31/2021","Acidity; Androgens; Animal Model; Bicarbonates; Biological; Biological Markers; Carbonates; Clinical; clinical translation; clinically relevant; clinically translatable; cohort; Data; deprivation; Detection; Disease; Disease Outcome; Disease Progression; Engineering; Event; Exclusion; experimental study; first-in-human; Genetically Engineered Mouse; Glycerol; Goals; Growth and Development function; high resolution imaging; Histologic; Human; Hydrolysis; Image; imaging biomarker; imaging modality; improved; insight; interstitial; Investigational Drugs; lymph nodes; Magnetic Resonance Imaging; Malignant neoplasm of prostate; Malignant Neoplasms; Maps; Measures; men; Metastatic Neoplasm to the Liver; Methods; Modeling; Molecular; mouse model; Neoplasm Metastasis; Noise; Oncogenic; Operative Surgical Procedures; outcome forecast; Pathologic; Pathway interactions; Patients; Pharmacology; Phase I Clinical Trials; Physiologic pulse; Preparation; Production; prognostic; Prostate; Prostate Adenocarcinoma; prostate cancer model; prostate cancer risk; Prostatic Neoplasms; Protocols documentation; PTEN gene; Quality Control; Resolution; Risk stratification; Role; Signal Transduction; Staging; Sterility; Techniques; Testing; transgenic adenocarcinoma of mouse prostate; Transgenic Organisms; Translations; tumor; tumor growth; ","Application of hyperpolarized 13C interstitial pH imaging to risk stratification in prostate cancer","026012","MEDI","Medical Imaging Study Section ","","","03","125000","32091","157091",""
"9912197","R01","MH","5","N","03/26/2020","03/01/2020","02/28/2021","242","R01MH109885","SCHOOLS OF MEDICINE","RFA-MH-16-300","5R01MH109885-05","NIMH:520041\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","LA JOLLA","UNITED STATES","PSYCHIATRY","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","PUBLIC HEALTH RELEVANCE Our study will help to gain insights into a molecular mechanism of ASD that is impacted by the de novo splice site mutations. By predicting and investigating cellular and molecular changes as a result of these mutations, we will uncover the pathways that may represent high priority targets for future therapeutic interventions.","7852260 (contact); 9661279; ","IAKOUCHEVA, LILIA M (contact); MUOTRI, ALYSSON R.;","ARGUELLO, ALEXANDER","05/01/2016","02/28/2021","16p11.2; Alternative Splicing; Animal Model; Attention; autism spectrum disorder; base; Binding; Biology; Brain; brain size; Cells; Copy Number Polymorphism; CRISPR/Cas technology; Data; Data Set; Databases; Development; Disease; disease-causing mutation; Exhibits; exome; follow-up; Future; Gene Expression; Genes; Genome; genome sequencing; Genotype-Tissue Expression Project; Goals; Human; human disease; human interactome; induced pluripotent stem cell; Information Networks; insight; interest; Maps; Mental disorders; Methods; Modeling; Molecular; molecular phenotype; mouse model; mutant; Mutate; Mutation; nerve stem cell; Neurons; Pathway interactions; Patients; Play; Post-Translational Protein Processing; Process; Property; Protein Isoforms; protein protein interaction; Proteins; Proteomics; public health relevance; Reporting; Risk; RNA Splicing; Role; Site; spatiotemporal; Specificity; Splice-Site Mutation; Testing; Therapeutic Intervention; Tissues; Transcript; transcriptome sequencing; transcriptomics; whole genome; Work; Yang; ","Evaluating the effect of splicing mutations on isoform networks in autism","109885","ZMH1","Special Emphasis Panel ","","","05","335510","184531","520041",""
"9928056","R01","ES","5","N","03/23/2020","03/01/2020","02/28/2021","113","R01ES011858","SCHOOLS OF MEDICINE","PA-18-484","5R01ES011858-29","NIEHS:541697\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","BALTIMORE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","We will investigate, in colorectal cancer (CRC) cells, assembly for key components of the NURD transcription complex which we have found can trigger, during reactive oxygen species induced DNA damage in CRC, initiation and maintenance of functional epigenetic abnormalities. We have tied the downstream repressed genes involved to the age-related risk of CRC in humans and have a model for this in organoids from colon. We will explore, including in our above model and with respect to key new proteins including PARP, UHRF1 and TET2, the hierarchy of complex assembly with a translational goal of targeting key members for new strategies to prevent, intersect, and manage CRC.","1871762 (contact); 10366365; 8252994; ","BAYLIN, STEPHEN B. (contact); EASWARAN, HARIHARAN ; RASSOOL, FEYRUZ VIRGILIA;","TYSON, FREDERICK L","04/01/1991","02/29/2024","actionable mutation; Acute; addiction; Affect; Age; age related; Aging; Base Excision Repairs; BRAF gene; cancer cell; Cancer Etiology; cancer initiation; cancer prevention; cancer risk; cancer statistics; cell assembly; Cessation of life; CHD4 gene; Chromatin; Chronic; Clinic; Clustered Regularly Interspaced Short Palindromic Repeats; Colon; Colon Carcinoma; Colorectal Cancer; colorectal cancer prevention; colorectal cancer progression; colorectal cancer risk; colorectal cancer treatment; Complex; CpG Island Methylator Phenotype; CpG Islands; Cryoelectron Microscopy; Data; Deacetylase; Derivation procedure; Developmental Gene; DNA; DNA Damage; DNA Methylation; DNA Modification Methylases; DNA Repair; DNA Repair Gene; Drug Targeting; Enhancers; Epigenetic Process; epigenetic therapy; Event; Evolution; Failure; Fostering; Funding; Gene Abnormality; Gene Expression; gene repression; Gene Silencing; Genes; Genetic; Genetic Transcription; Goals; Human; in vitro Model; in vivo; Inflammation; Intercept; Lasers; Link; Maintenance; Maps; member; Methylation; methylation pattern; Modeling; Molecular; Mus; Mutate; Mutation; nanometer; novel; Nucleosomes; NuRD complex; Oncogenes; One-Step dentin bonding system; Organoids; outcome forecast; Pathway interactions; Pharmaceutical Preparations; Positioning Attribute; prevent; Prevention strategy; prognostic significance; promoter; Proteins; Reactive Oxygen Species; recruit; Resolution; response; Risk; Role; Series; Site; small hairpin RNA; stem-like cell; stemness; Stress; Structure; targeted treatment; Tertiary Protein Structure; Time; Translations; tumor; tumor progression; Tumor Suppressor Genes; tumorigenesis; Tumorigenicity; Work; working group; Yang; ","DNA Methyltransferase Gene Expression in Colon Cancer","011858","CE","Cancer Etiology Study Section ","","","29","419660","122037","541697",""
"9939708","U54","MD","5","N","03/18/2020","02/01/2020","01/31/2021","","U54MD007597","","RFA-MD-17-006","5U54MD007597-32","NIMHD:418665\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","WASHINGTON","UNITED STATES","","98","056282296","US","3499801","HOWARD UNIVERSITY","DC","200590005","","2064409; ","SOUTHERLAND, WILLIAM M;","","","","Achievement; Advisory Committees; Biomedical Research; Clinical Research; Collection; Communities; cost; Data Analyses; Development; Effectiveness; Evaluation; Evaluation Reports; Generations; Goals; health disparity; Logistics; Maintenance; minority health; Monitor; Performance; Principal Investigator; programs; Recommendation; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Review Committee; Role; Services; Time; Training; Training Activity; training opportunity; Universities; ","Administrative Core","007597","ZMD1","Special Emphasis Panel ","5945","","32","328544","181720","","418665"
"9939716","U54","MD","5","N","03/18/2020","02/01/2020","01/31/2021","","U54MD007597","","RFA-MD-17-006","5U54MD007597-32","NIMHD:141493\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","WASHINGTON","UNITED STATES","","98","056282296","US","3499801","HOWARD UNIVERSITY","DC","200590005","","9890781; ","GHOSH, SOMIRANJAN ;","","","","Address; Affect; African American; Age-Years; base; Biological; Biological Assay; burden of illness; Candidate Disease Gene; Categories; Cause of Death; Cessation of life; Chronic Hepatitis C; chronic liver disease; Cirrhosis; Clinical; Collaborations; collaborative approach; Communities; Comorbidity; Complex; Coupled; Data; density; Diabetes Mellitus; diabetic; diabetic patient; Disease; Disease Marker; District of Columbia; Enrollment; Epidemiology; Ethnic group; experience; experimental study; Gene Expression; Gene Expression Profiling; Genes; Genetic; genetic signature; Goals; Health; health disparity; Hepatitis C; Hepatitis C virus; Infection; Insulin Resistance; Knowledge; Laboratories; Leukocytes; Light; Liver; Liver Cirrhosis; Malignant neoplasm of liver; Metabolic; Methodology; Minority; minority health; Mission; Molecular Profiling; negative affect; Non-Insulin-Dependent Diabetes Mellitus; novel strategies; Outcome; Participant; Pathogenicity; Pathway interactions; patient population; Patients; Persons; Population; Population Research; Prevention; profiles in patients; recruit; Reproducibility; Research; Resources; Risk; Risk Factors; Severities; Testing; Tissue-Specific Gene Expression; transcriptome; Universities; Validation; Viral Pathogenesis; Washington; ","Molecular and Genetic Signatures of Perturbed Diabetic Pathways with Hepatitis C Virus infection and Co-morbidity Risks in African American Population","007597","ZMD1","Special Emphasis Panel ","5949","","32","132841","45688","","141493"
"9990511","F31","DK","1","N","02/28/2020","03/26/2020","03/25/2021","847","F31DK124080","GRADUATE SCHOOLS","PA-19-195","1F31DK124080-01A1","NIDDK:37924\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","DAVIS","UNITED STATES","NONE","03","047120084","US","577503","UNIVERSITY OF CALIFORNIA AT DAVIS","CA","956186153","PROJECT NARRATIVE  Non-alcoholic fatty liver disease (NAFLD) affects a quarter of the global population and is the most common cause of chronic liver disease, but there are currently no available therapeutics. Fibroblast growth factor-21 (FGF21) is a liver-produced hormone that decreases hepatic triglycerides and has therefore gained tremendous interest as a novel therapeutic for NAFLD, but the mechanism by which FGF21 causes this decrease is unclear. The proposed study is expected to elucidate this mechanism and also reveal new potential targets for the treatment of NAFLD.","14076781; ","CHAFFIN, AKI TERATA-BOWERS;","DENSMORE, CHRISTINE L","03/26/2020","03/25/2022","Adipocytes; Affect; analog; autocrine; Biochemical Pathway; Brain; Brain region; Cannulations; career; chronic liver disease; Cirrhosis; Clinical Trials; clinically relevant; Comorbidity; Data; Development; Diet; Disease; experimental study; Fatty Liver; fibroblast growth factor 21; Fibrosis; Genetic; Goals; Hepatic; Hepatocyte; Hormones; Hypothalamic structure; improved; Injections; insight; interest; intraperitoneal; Intuition; Investigation; knock-down; Light; lipid metabolism; Lipids; Liver; LoxP-flanked allele; Measures; Mediating; Mentorship; Metabolism; Modeling; Mus; Nerve; Neuraxis; non-alcoholic fatty liver disease; Norepinephrine; novel; novel therapeutics; Obese Mice; Obesity; Organ; paracrine; Pathology; Pathway interactions; Pharmacologic Substance; Pharmacology; Population; Preparation; Prevalence; receptor; Reporting; Research; response; Role; Scientist; Signal Transduction; Site; Steatohepatitis; suprachiasmatic nucleus; Sympathectomy; Sympathetic Nervous System; Techniques; Testing; Therapeutic; Time; Training; Translational Research; Triglycerides; Work; ","Central mechanisms of fibroblast growth factor-21 to decrease hepatic triglycerides","124080","ZDK1","Special Emphasis Panel ","","A1","01","37924","","37924",""
"10050164","P30","CA","3","N","03/25/2020","12/01/2019","11/30/2020","397","P30CA016086","SCHOOLS OF MEDICINE","PAR-13-386","3P30CA016086-44S2","NCI:133332\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","CHAPEL HILL","UNITED STATES","INTERNAL MEDICINE/MEDICINE","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","NARRATIVE The Lineberger Comprehensive Cancer Center (LCCC) forms the nexus for researchers focused on understanding and identifying the mechanisms leading to, the prevention of, and treatments for cancer. LCCC is an integral component of the research mission at The University of North Carolina (UNC) at Chapel Hill, coalescing the cancer research capabilities of the Schools of Medicine, Public Health, Pharmacy, and Nursing, and the College of Arts and Sciences. The LCCC strives to reduce cancer incidence, morbidity, and mortality in North Carolina, the United States and across the globe through innovative research, cutting-edge treatments, multi-disciplinary training, education and outreach.  ","6477317; ","EARP, HENRY SHELTON;","SHAFIK, HASNAA","06/01/1997","11/30/2020","Address; African American; angiogenesis; anticancer research; Apoptosis; Area; Arts; Basic Cancer Research; Basic Science; Behavior Therapy; Big Data; Biochemistry; Biological; Biology; Blood Vessels; Breast; Cancer Biology; cancer care; cancer cell; Cancer Center; Cancer Center Support Grant; cancer health disparity; Cancer Intervention; cancer therapy; Caregivers; Case-Control Studies; Catchment Area; Cell Cycle; Cell Cycle Regulation; cell motility; Cells; Cellular biology; Cessation of life; Chromatin; Clinical; clinical care; Clinical Research; Clinical Sciences; Clinical Trials; Cohort Studies; college; Colon; combat; Comprehensive Cancer Center; Core Facility; cost; Data; Dentistry; Development; Devices; Diagnostic; Discipline of Nursing; DNA biosynthesis; DNA Repair; Early Diagnosis; Education and Outreach; effective therapy; Ensure; Epidemiology; Epigenetic Process; Etiology; Extramural Activities; Faculty; Fostering; Foundations; Funding; Future; Gap Junctions; Generations; Goals; Grant; Growth Factor Receptors; Health Services; Healthcare Systems; Home environment; Hospitals; Incidence; innovation; insight; Intervention; Investigation; Leadership; Malignant Neoplasms; medical schools; member; Metabolism; Minority; Mission; Modernization; Molecular; Morbidity - disease rate; mortality; multidisciplinary; Neoplasm Metastasis; new therapeutic target; North Carolina; novel; oncology; Outcome; outreach; Pathogenesis; Pharmacy facility; Population; Population Sciences; Population Study; Pre-Clinical Model; Prevention; programs; Prostate; Public Health; Publishing; Research; research and development; Research Design; Research Personnel; Resistance; Risk Factors; RNA; Role; Science; Scientist; Signal Transduction; student training; Students; survivorship; targeted cancer therapy; Therapeutic; Therapeutic Intervention; Training; Training and Education; Transcriptional Regulation; Translational Research; tumor initiation; tumor registry; underserved minority; Underserved Population; United States; Universities; Ursidae Family; Work; ","Cancer Center Support Grant","016086","NCI","Subcommittee H - Clinical Groups ","","S2","44","85744","47588","133332",""
"10073345","IK2","VA","5","N","03/24/2020","04/01/2019","03/31/2020","999","IK2RX001180","","RFA-RX-13-009","5IK2RX001180-05","","OTHERS","2020","Veterans Affairs","","CLEVELAND","UNITED STATES","","14","093016124","US","481118","LOUIS STOKES CLEVELAND VA MEDICAL CENTER","OH","441413204","PUBLIC HEALTH RELEVANCE:     Primary fatigue represents a major cause of disability in patients with multiple sclerosis (MS), being reported in about 90% of cases. Fatigue interferes with everyday functioning but, unfortunately, little is known about its mechanisms. We propose a characteristic eye movement abnormality (internuclear ophthalmoparesis, INO), commonly encountered in MS, as a simple model for primary motor fatigue. We described worsening of ocular performance in MS patients with INO following visual tasks (ocular motor fatigue), which is likely due to decreased neural conduction along brain pathways injured by MS. This mechanism could represent a major component of MS-related primary motor fatigue. Relevant to Veterans' care, INO is a significant cause of visual disability, especially when complicated by ocular fatigue, and limits daily activities such as reading and driving. We propose a medical treatment to improve ocular performance/fatigue in INO, which can reduce visual disability and improve quality of life in our Veterans with MS.","11420409; ","SERRA, ALESSANDRO ;","","04/01/2015","03/31/2020","Abnormal coordination; Acceleration; adduct; Affect; Aftercare; associated symptom; Automobile Driving; Axon; base; brain pathway; Brain Stem; Caring; Categories; Characteristics; Clinical; Cognitive; Cross-Over Trials; Data; deconditioning; Demyelinations; Deterioration; disability; Disease; Double-Blind Method; Dyskinetic syndrome; effective therapy; efficacy testing; Enrollment; Equipment and supply inventories; Exercise; Exhibits; Eye; Eye Movements; Fatigue; FDA approved; foot; Frequencies; Functional disorder; Gait; gaze; Generations; horizontal gaze; Impairment; improved; improved functioning; Inflammation; injured; Limb structure; mathematical model; Measures; Medial; Medical; Mental Depression; Modeling; Motor; motor deficit; Multiple Sclerosis; multiple sclerosis patient; Muscle Fatigue; Neural Conduction; Neuraxis; Neurons; neurophysiology; neurotransmission; Nose; Ocular Motility Disorders; oculomotor; Ophthalmopareses; Outcome Measure; Pathway interactions; Patients; Performance; Pharmaceutical Preparations; Physiologic pulse; Placebos; Play; Population; Potassium Channel Blockers; Psyche structure; public health relevance; Quality of life; Quality-of-Life Assessment; Questionnaires; Randomized; Reading; Rehabilitation therapy; Reporting; Reproducibility; response; Role; Saccades; Severities; Signal Transduction; Site; Sleep Disorders; Speed; Testing; Time; transmission process; Veterans; Vision; Visual; visual performance; Walking; ","Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis","001180","RRD8","Career Development Program - Panel I ","","","05","","","",""
"10092607","DP5","OD","7","N","03/24/2020","02/01/2020","08/31/2020","310","DP5OD028155","EARTH SCIENCES/RESOURCES","PA-18-590","7DP5OD028155-02","NIDCR:1\OD:330454\","Non-SBIR/STTR RPGs","2019","OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH","","LEXINGTON","UNITED STATES","ZOOLOGY","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","Allergies affect more than 50 million people in the United States, with estimates of health costs exceeding $18 billion annually. Central to combatting allergic disease and asthma are efforts to understand the environmental risk factors that induce allergic responses. This project, stemming from my recent discovery that bed bugs disseminate large amounts of histamine in their feces, will comprehensively document the prevalence and distribution of histamine in homes infested with bed bugs and determine the risks of exogenous histamine exposure to human health, both of which are critical to promote human health and well-being in the indoor environment.","15186293; ","DEVRIES, ZACHARY ;","BASAVAPPA, RAVI","09/16/2019","08/31/2024","","Histamine in homes: Exposure risks and health effects","028155","ZRG1","Special Emphasis Panel ","","","02","220660","109795","330455",""
"10119349","R01","HD","7","N","03/26/2020","03/26/2020","06/30/2020","865","R01HD079113","OVERALL MEDICAL","PA-18-480","7R01HD079113-07","NICHD:484473\","Non-SBIR/STTR RPGs","2019","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","PISCATAWAY","UNITED STATES","NONE","06","078795875","US","10034170","RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL","NJ","088548021","Project Narrative This project aims to improve treatment and to prevent relapse for severe destructive behavior exhibited by children with developmental disabilities.24,25,78 Relapse, the increase in destructive behavior after initially effective treatment, is a common problem that negatively impacts long-term treatment effectiveness and often occurs when: (a) we transfer treatment to different therapists, caregivers, or settings;19 (b) caregivers stop delivering reinforcement for appropriate, alternative behavior;9 and (c) caregivers deliver reinforcement at unplanned times.15 Our novel treatment will be more effective and will mitigate or prevent relapse more often than traditional treatments.","3122741; ","FISHER, WAYNE W;","KING, TRACY","07/11/2014","06/30/2024","","Stimulus Control Refinements of Functional Communication Training in ID","079113","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","","07","387345","97128","484473",""
"10131356","R01","DE","3","N","03/24/2020","01/15/2020","03/31/2020","121","R01DE026122","","RFA-DE-16-007","3R01DE026122-04S1","NIDCR:15436\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH","","CHICAGO","UNITED STATES","","07","789085941","US","256502","AMERICAN DENTAL ASSOCIATION FOUNDATION","IL","606112637","Narrative With root caries prevalence in older adults being reportedly as high as 90 %, the expected demographic elderly boom will inevitably lead to a substantial increase in need for root caries treatments. Conventional Class V restoratives do not address comprehensively the specific challenges typical for elderly population with generally deteriorated health, reduced salivary flow and compromised periodontium. Glass ionomer cements (GICs) and resin-modified GICs, predominantly used for this purpose, exhibit a burst release of fluoride (F) and no sustained remineralization. Generally, the antimicrobial (AM) activity of these restoratives has been neglected, and clinically marginalized. This proposal, submitted in response to the RFA-DE-16-007, leans strongly on our group?s unique experience with amorphous calcium phosphate (ACP)-based dental materials. By applying lessons learned from the structure/composition/property studies of polymeric ACP systems, we propose to design AM remineralizing polymeric composites capable of simultaneously responding to microbial challenges due to the presence of AM functionalities in their polymer phase, and regenerating tooth mineral phases due to the bioactivity of ACP filler. Both AM and remineralizing function will be long-lived. New, resin-compatible, AM poly-functional monomers and coupling agents and ACP will be incorporated into highly cross- linked, yet flexible resins. The AM resins and the ensuing ACP composites will be evaluated for their physicochemical, mechanical properties and biological/cellular responses under conditions closely simulating a dynamic oral milieu. Newly designed materials are also expected to outperform the conventional Class V controls with respect to leachability of the unreacted monomers and polymerization shrinkage, while matching their mechanical performance and bonding properties. Successful completion of this application will yield a prototype(s) Class V composite(s) suitable for further testing in animal studies and/or in randomized clinical trials.","2792835; ","SKRTIC, DRAGO ;","LOPEZ, ORLANDO","01/15/2020","03/31/2021","Acids; Address; Adhesiveness; Adhesives; Adult; Affect; Animals; antimicrobial; antimicrobial drug; Antimicrobial Effect; base; Biological; biomaterial compatibility; Biomimetics; Calcium; calcium phosphate; Cells; chemical property; Chemicals; Chemistry; Clinical; Clinical Treatment; Clinical Trials; combat; Composite Resins; copolymer; Coupling; crosslink; cytotoxicity; demineralization; Dental; Dental caries; Dental crowns; Dental Enamel; Dental Materials; Dentin; design; Disease; Elderly; Endodontics; Environment; Evaluation; Exhibits; experience; Filler; flexibility; Fluorides; Formulation; Generations; Glass Ionomer Cements; Goals; Health; High Prevalence; Immobilization; improved; Interdisciplinary Study; Ions; Lead; Mammalian Cell; mechanical properties; Mechanics; microbial; mineralization; Minerals; monomer; National Institute of Dental and Craniofacial Research; neglect; NMR Spectroscopy; novel strategies; nucleophilic substitution; Oral; Orthodontic; Particle Size; Performance; Periodontium; Phase; physical property; Pit and Fissure Sealants; Plant Resins; polymerization shrinkage; polymerization stress; Polymers; Population; Prevalence; prevent; Procedures; Property; Protons; prototype; Psychological reinforcement; Randomized Clinical Trials; Reaction; Regimen; remineralization; Repair Material; Research; response; restoration; Root Caries; Salivary; Scientist; Solid; Spectroscopy, Fourier Transform Infrared; stem; Structure; Surface; System; Technology; Testing; Thermodynamics; Thinness; tissue repair; tool; Tooth regeneration; Tooth structure; Toxic effect; treatment strategy; Validation; ","ANTIMICROBIAL AND REMINERALIZING COMPOSITES FOR CLASS V RESTORATIONS","026122","ZDE1","Special Emphasis Panel ","","S1","04","9895","5541","15436",""
"9703468","P01","AG","2","N","03/25/2020","04/01/2019","03/31/2020","866","P01AG014449","","PAR-18-297","2P01AG014449-22","NIA:2659479\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","PHOENIX","UNITED STATES","","07","131606022","US","2052813","ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER","AZ","850134409","Project Narrative This program renewal will provide a greater understanding of the pathogenesis of a critical brain network that modulates cognitive function by identifying connectome deficits during preclinical Alzheimer?s disease (AD) so early treatment strategies can be implemented. Proposed studies are relevant to the NIA mission supporting research to define the cellular and molecular biology of dementia at the earliest stage of onset, which provide targets for transcriptionally aided drug discovery at a time when no treatments exist for AD.","2183135; ","MUFSON, ELLIOTT JAY;","OPANASHUK, LISA A","09/01/1997","03/31/2024","Acetylcholine; AD pathology; Affect; age related; Alzheimer's Disease; Amyloid; Amyloid beta-Protein; Animal Model; Anterior; Atrophic; Automobile Driving; basal forebrain; basal forebrain cholinergic neurons; base; Biological; Brain; Brain Diseases; brain tissue; Case Study; Cell model; cholinergic; Clinical; Cognitive; cognitive function; Cohort Studies; Complement; Complex; connectome; data management; Defect; Dementia; Disease; drug discovery; Drug or chemical Tissue Distribution; Early treatment; Elderly; Event; executive function; FDA approved; Functional disorder; Genetic Transcription; Goals; Gold; Human; human tissue; Impaired cognition; in vivo; Individual; Institutes; interest; Intervention; Lead; Measures; Memory; Michigan; MicroRNAs; mild cognitive impairment; Mission; Molecular; Molecular and Cellular Biology; multidisciplinary; Nerve Degeneration; Neuroanatomy; Neurobiology; Neurodegenerative Disorders; neuroimaging; neuroinflammation; Neurologic; neuron loss; neuronal circuitry; Neuronal Plasticity; Neurons; neuropathology; Neurotransmitters; novel; novel therapeutic intervention; novel therapeutics; Nuclear; Onset of illness; Participant; Pathogenesis; Pathologic; Pathology; Pharmaceutical Preparations; Phase; Play; pre-clinical; Pre-Clinical Model; preservation; prevent; Process; Program Research Project Grants; programs; Proteins; public health priorities; Religion and Spirituality; Research; Research Design; Research Project Grants; Research Support; resilience; Role; Route; Scientist; Series; statistics; Stress; Suggestion; Synapses; System; Systems Biology; tau mutation; tau Proteins; Testing; Therapeutic; Time; Tissues; treatment strategy; Universities; Vulnerable Populations; ","Neurobiology of Mild Cognitive Impairment in the Elderly","014449","ZAG1","Special Emphasis Panel ","","","22","2052704","606775","2659479",""
"9703470","P01","AG","2","N","03/25/2020","04/01/2019","03/31/2020","","P01AG014449","","PAR-18-297","2P01AG014449-22","NIA:306781\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","PHOENIX","UNITED STATES","","07","131606022","US","2052813","ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER","AZ","850134409","","14375337; ","MALEK-AHMADI, MICHAEL ;","","","","Address; Alzheimer's Disease; Alzheimer's Disease Core Center; basal forebrain; Bioinformatics; case-based; Cellular Neurobiology; Chicago; cholinergic; Clinical; Cognitive; Data; Data Analyses; Data Analytics; data management; Data Set; Databases; Diagnosis; Disease Progression; Elderly; Ensure; Exclusion Criteria; experience; Goals; human tissue; Laboratories; Libraries; Link; mild cognitive impairment; Mission; Molecular; Molecular Neurobiology; Network-based; Neurobiology; Pathologic; pre-clinical; Program Research Project Grants; Religion and Spirituality; Research; Research Design; Research Personnel; Research Project Grants; Resources; Specific qualifier value; Statistical Data Interpretation; statistics; success; Tissue Sample; Tissues; ","Core B - Statistical and Data Management","014449","ZAG1","Special Emphasis Panel ","7795","","22","185426","121355","","306781"
"9832993","F31","MH","1","N","07/02/2019","09/01/2019","08/31/2020","242","F31MH120920","","PA-18-671","1F31MH120920-01","NIMH:24816\","TRAINING, INDIVIDUAL","2019","NATIONAL INSTITUTE OF MENTAL HEALTH","","TORONTO","CANADA","","","259999779","CA","8360001","UNIVERSITY OF TORONTO","ON","M5S 1S8","Project Narrative  This proposal will characterize how the development of perineuronal nets in in the hippocampus contributes to the ontogeny of memory specificity. It will dissect how generalized versus specific memories are differentially represented by neuronal ensembles across development and the role of link protein HAPLN1 in the early transition from memory generalization to specificity. This proposal will identify the brain extracellular matrix as a key regulator of memory development.","12588971; ","RAMSARAN, ADAM I;","PINARD, COURTNEY","09/01/2019","08/31/2021","Address; Adult; Age; age related; Amnesia; Animal Model; Behavior; Behavioral; Biological Process; Brain; Brain Diseases; Brain-Derived Neurotrophic Factor; Characteristics; Child; Childhood; Chondroitin ABC Lyase; Chondroitin Sulfate Proteoglycan; conditioned fear; crosslink; Cyclophosphamide; Data; Dependovirus; depressive symptoms; Development; Dorsal; early childhood; Enzymes; episodic like memory; Episodic memory; Event; Excision; Exhibits; experience; Extracellular Matrix; fear memory; foot; forgetting; Foundations; Freezing; Fright; generalized anxiety; Growth; Hippocampus (Brain); human model; human subject; Hyaluronan; Impairment; infancy; Infant; insight; interest; Interneurons; janusin; Knowledge; Life; link protein; Measures; Mediating; Memory; memory retrieval; Modeling; Molecular; Mus; Mutate; Neurobiology; neuromechanism; Neurons; Neurosciences; novel; optogenetics; overexpression; Post-Traumatic Stress Disorders; postnatal; Proteins; Proteoglycan; Psychologist; Publishing; Rattus; Regulation; Research; Rodent; Role; Shock; Specificity; Stimulus; Structure; Techniques; Testing; Time; Training; Vertebral column; Viral; Viral Genes; Work; ","Developmental Regulation of Memory Specificity by the Brain Extracellular Matrix","120920","ZRG1","Special Emphasis Panel ","","","01","24816","","24816",""
"9854054","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:162645\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","8033823; ","TENNENT, BARBARA J;","","","","Abbreviations; Administrative Personnel; Administrator; Advisory Committees; Agreement; Award; Budgets; Cancer Center; Cancer Center Support Grant; cancer education; cancer research center director; career; Center for Translational Science Activities; Clinical; Clinical Research; cohesion; Collaborations; Communication; Computational Science; Coordinating Center Administration; Core Grant; cost effective; Development; Education; Ensure; Evaluation; Faculty; Funding; Funding Agency; Future; Genetic Engineering; Genome; Genomics; Goals; Grant; Growth; Health Services Research; innovation; Israel; Laboratories; Leadership; Malignant Neoplasms; Medical center; meetings; member; Mentors; microbial; Names; operation; Organization administrative structures; outreach; Phenotype; Pilot Projects; Policies; precision oncology; Process; Program Development; programs; quality assurance; recruit; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Science; Services; single cell technology; Southwest Oncology Group; Staff Development; symposium; Technology; The Jackson Laboratory; Training; translational cancer research; Translational Research; Travel; Vision; Work; ","Cancer Center Administration","034196","NCI","Subcommittee H - Clinical Groups ","7968","","34","93774","68871","","162645"
"9867627","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","397","P30CA046934","SCHOOLS OF MEDICINE","PAR-13-386","5P30CA046934-32","NCI:3853226\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","NONE","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","PROJECT NARRATIVE The University of Colorado Cancer Center (UCCC) is an NCI-designated matrix consortium of six academic institutions and clinical affiliates encompassing the State of Colorado as its catchment area. Bringing together nearly all NCI-funded investigators in the State, the UCCC has established a multidisciplinary nexus of research excellence in the fight against cancer with a mission to discover, develop, and deliver breakthroughs in cancer science. Skillful management and key recruitments over the past 5 years led to impactful innovations in cancer biology that translated into prevention, diagnostic and therapeutic strategies in clinical trials and commercialization. The UCCC also addresses needs of underserved populations by providing targeted, culturally appropriate behavioral interventions, colorectal cancer screenings and shaping state tobacco control legislation. CCSG renewal and new institutional commitments of $65M and 20K sf of space will continue our upward trajectory and enhance our fight against cancer for Colorado and the world.","6713387; ","SCHULICK, RICHARD D;","HE, MIN","04/04/1997","01/31/2022","Acute Myelocytic Leukemia; Address; Adult; Androgen Antagonists; Androgen Receptor; Automobile Driving; Autophagocytosis; Award; base; Behavior Therapy; Behavioral Sciences; Biomedical Engineering; Breast Carcinoma; Cancer Biology; Cancer Burden; cancer care; cancer cell; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Model; cancer prevention; cancer risk; Cancer Science; cancer survival; Cancer Therapy Evaluation Program; Catchment Area; Cellular biology; Clinical; Clinical Research; Clinical Trials; Colon Carcinoma; Colorado; colorectal cancer risk; colorectal cancer screening; commercialization; comparative; Complement; Computational Biology; Consultations; Coordination and Collaboration; Critiques; design; Development; Developmental Therapeutics Program; Diagnostic; diet and exercise; Disease; Early Therapeutic-Clinical Trials Network; Ecology; Education; Ensure; Epidemiology; Epigenetic Process; Faculty; Faculty Recruitment; fight against; functional genomics; fundamental research; Funding; Future; Gap Junctions; Genomics; Genotype; Grant; Guanosine Triphosphate Phosphohydrolases; Hand; Head Cancer; health care delivery; Health Services; Healthcare Systems; Hematologic Neoplasms; high risk; Hispanics; Hospitals; Hypoxia; Immunobiology; Immunotherapy; In Situ; Infrastructure; inhibitor/antagonist; innovation; Institution; Interdisciplinary Study; Intervention; Intervention Trial; investigator-initiated trial; Investments; Laboratories; Leadership; Legal patent; Licensing; Lung; malignant breast neoplasm; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Malignant neoplasm of urinary bladder; Malignant Neoplasms; Mediation; medical schools; Medicine; member; Mentorship; Metabolic Pathway; Mission; Molecular; molecular oncology; Molecular Structure; Mucositis; multidisciplinary; National Comprehensive Cancer Network; NCI Center for Cancer Research; Neck Cancer; Network-based; New Agents; next generation; Noninfiltrating Intraductal Carcinoma; novel; novel therapeutics; NTRK1 gene; oncology; Oral; Palliative Care; Patient Care; Patients; Pediatric Hospitals; Peer Review; Policy Research; Population Sciences; Postpartum Period; Pre-Clinical Model; Prevention; Prevention trial; Primary Health Care; programs; Protocols documentation; PTGS2 gene; Publications; Radiation; recruit; Research; Research Infrastructure; Research Personnel; Resistance; Resource Sharing; Role; Scientific Advances and Accomplishments; Scientist; screening; Secure; Shapes; Signal Pathway; Site Visit; Statutes and Laws; structural biology; Survivors; targeted agent; Technology; The University of Colorado Cancer Center; Therapeutic; tobacco control; Training; Translating; Translational Research; Translations; treatment strategy; treatment trial; undergraduate student; Underserved Population; United States National Institutes of Health; Universities; Writing; ","University of Colorado Cancer Center Support Grant","046934","NCI","Subcommittee H - Clinical Groups ","","","32","2526044","1327182","3853226",""
"9867662","P30","CA","5","N","03/26/2020","02/01/2020","01/31/2021","","P30CA046934","","PAR-13-386","5P30CA046934-32","NCI:280729\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","Aurora","UNITED STATES","","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","","6182841; ","THEODORESCU, DAN ;","","","","Address; Animals; anticancer research; Applications Grants; Area; base; Biochemistry; Bioinformatics; Bioinformatics Shared Resource; bioinformatics tool; biomedical informatics; Biometry; Biostatistics Core; Budgets; Cancer Center; Cancer Center Support Grant; cancer clinical trial; Catchment Area; Clinical; Clinical Research; Clinical Sciences; Clinical trial protocol document; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Colorado; Communities; Consultations; Data; Data Analyses; Data Quality; Data Set; Department chair; design; Development; Doctor of Philosophy; Education; Educational workshop; Ensure; Epidemiology; Evaluation; experience; Faculty; Fees; fundamental research; Funding; Future; Genetic; genetic variant; Genomics; Genomics Shared Resource; Goals; Grant; Growth; Health; Health Services Research; high throughput analysis; Individual; Informatics; Institutes; Institution; Investigational Therapies; Knowledge; Laboratories; Leadership; malignant breast neoplasm; Malignant Neoplasms; Manuscripts; Medicine; member; Methodology; Methods; Mining; Mission; Molecular Genetics; molecular pathology; Monitor; Monitoring Clinical Trials; multidimensional data; Mutation; next generation sequencing; novel; Outcome; Outcome Study; patient safety; Peer Review; personalized medicine; Play; Population Research; Population Sciences; Population Study; Positive Lymph Node; predictive modeling; Preparation; professor; programs; Protocols documentation; Publications; Radiation Oncology; Radiation therapy; Reporting; Reproducibility; Research; Research Assistant; Research Design; Research Personnel; Research Project Grants; research study; Resistance; Resource Sharing; Resources; Role; Safety; Sample Size; Sampling; Scoring Method; Series; Services; Statistical Methods; Summary Reports; symposium; System; targeted agent; Technology; The University of Colorado Cancer Center; Therapeutic Studies; tool; Training; Translational Research; tumor; Universities; virtual; web page; Work; ","Biostatistics / Bioinformatics Shared Resource","046934","NCI","Subcommittee H - Clinical Groups ","5060","","32","180864","99865","","280729"
"9881327","R01","HD","5","N","03/24/2020","03/01/2020","02/28/2021","865","R01HD096909","SCHOOLS OF MEDICINE","PA-18-480","5R01HD096909-02","NICHD:671019\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","NEW YORK","UNITED STATES","PEDIATRICS","12","121911077","US","5998304","NEW YORK UNIVERSITY SCHOOL OF MEDICINE","NY","10016","PROJECT NARRATIVE Public health disasters have disproportionate impacts on low income communities, through pathways that add to those of poverty and associated stressors, and act over extended periods. Very young children are highly vulnerable to long-term impacts on development and mental health in the context of parenting challenges following disasters, yet frequently receive the least attention and resources. This study will test the role of universal parenting support in enhancing young children's development and mental health in Flint, Michigan following the Flint Water Crisis.","1912106; ","MENDELSOHN, ALAN L.;","GRIFFIN, JAMES","03/01/2019","02/29/2024","3 year old; Address; adverse outcome; Anger; Anxiety; Area; Attention; base; Birth; blood lead; Buffers; Caring; Characteristics; Child; Child Behavior; Child Development; child mental development; child poverty; Child Rearing; Childhood; Chronic; Clinic; Cluster Analysis; Communities; Community Surveys; contaminated drinking water; contaminated water; Corrosives; Cost Savings; Data; Data Analyses; Development; Disasters; Enrollment; experience; Exposure to; Failure; Family; follow-up; Goals; Government; Health; health data; Healthcare; infancy; innovation; Intervention; Knowledge; Lead; lead contamination; lead exposure; Lead levels; Link; longitudinal analysis; Low income; Maps; Measures; Mediating; Mental Health; Methods; Michigan; Modeling; National Institute of Child Health and Human Development; Neighborhoods; Newborn Infant; novel; Outcome; Parent-Child Relations; Parents; Participant; Pathway interactions; Patient Self-Report; Pattern; Periodicity; Plant Roots; Population; population based; Poverty; prevent; Prevention; Preventive; Preventive Intervention; Primary Health Care; Primary Prevention; programs; psychosocial; Public Health; Race; racial disparity; Randomized; Research Priority; Resources; response; Rivers; Role; routine care; Safety; socioeconomic disparity; socioeconomics; Stress; stressor; Testing; therapy development; Time; Toxicology; Trauma; Variant; Video Recording; Water; water quality; Water Supply; ","Universal strengths-based parenting support in pediatric health care for families with very young children following the Flint Water Crisis","096909","PDRP","Psychosocial Development, Risk and Prevention Study Section ","","","02","577587","93432","671019",""
"9884769","R01","EY","5","N","03/24/2020","03/01/2020","02/28/2021","867","R01EY027701","SCHOOL OF MEDICINE & DENTISTRY","PA-13-302","5R01EY027701-04","NEI:518435\","Non-SBIR/STTR RPGs","2020","NATIONAL EYE INSTITUTE","","ROCHESTER","UNITED STATES","OPHTHALMOLOGY","25","041294109","US","7047101","UNIVERSITY OF ROCHESTER","NY","146270140","Vision loss in glaucoma is caused by the death of retinal ganglion cells (RGCs), the output neurons in the retina. The endothelin system has been hypothesized to be involved in RGC death. This application will critically test the importance of this pathway in a widely used mouse model of glaucoma. Furthermore, the signaling pathways that control activation of the endothelin system in the retina will be identified. Together, these data will identify potential pharmaceutical targets for the treatment and prevention of glaucoma as well as genes that may underlie patient susceptibility to vision loss.","10363075; 8746232 (contact); ","HOWELL, GARETH R; LIBBY, RICHARD T (contact);","LIBERMAN, ELLEN S","03/01/2017","02/28/2022","Affect; Animal Model; Astrocytes; axonal degeneration; Axonal Transport; Biological; Blindness; Cause of Death; Cell Death; cell type; Cells; Cellular Morphology; Cessation of life; Critical Pathways; Data; Disease; Disease Progression; EDN2 gene; Endothelial Cells; Endothelin; Endothelin Receptor; Event; experimental study; Functional disorder; Gene Expression Profiling; Genes; Genetic; genetic approach; genome-wide; Glaucoma; Goals; Human; human model; in vivo evaluation; Individual; Injury; Intervention; intravitreal injection; Ischemia; Ligands; macrophage; Mediating; Microglia; Modeling; Molecular; monocyte; Morphology; mouse model; Muller's cell; Mus; Mutant Strains Mice; Myelogenous; Myeloid Cells; Nature; Nerve Degeneration; neuroinflammation; Neurons; novel; Ocular Hypertension; Onset of illness; Optic Disk; Optic Nerve; optic nerve disorder; Outcome Measure; Output; Pathogenesis; Pathogenicity; Pathologic; Pathway interactions; Patients; Pericytes; Pharmacologic Substance; Pharmacology; Physiological; Play; Predisposition; prevent; Prevention; Process; receptor; Receptor Cell; Research Design; response; Retina; Retinal; retinal damage; Retinal Ganglion Cells; Role; Signal Pathway; Signal Transduction; Smooth Muscle Myocytes; Study models; System; Testing; Tissues; transcription factor; transcriptome sequencing; transcriptomics; Up-Regulation; Vascular Smooth Muscle; ","Cell specific roles of the endothelin system in glaucoma-relevant retinal ganglion cell death","027701","ZRG1","Special Emphasis Panel ","","","04","433294","85141","518435",""
"9888431","R01","MH","5","N","03/25/2020","03/25/2020","02/28/2021","242","R01MH113619","SCHOOLS OF MEDICINE","PA-16-160","5R01MH113619-03","NIMH:628206\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","NEW YORK","UNITED STATES","PSYCHIATRY","13","078861598","US","3839801","ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI","NY","100296574","Dysconnectivity between brain regions is the leading systems-level model for psychosis, but the neurobiological origins of this dysconnectivity are poorly understood. This proposal tests the hypothesis that psychotic dysconnectivity arises from abnormalities in cortical myelination that alter the topological role of brain regions in the structural and functional connectome. We will thus provide crucial mechanist insights into the origins of dysconnectivity in psychosis and potential new targets for novel interventions.","9493261; ","FRANGOU, SOPHIA ;","ZALCMAN, STEVEN J","05/10/2018","02/28/2022","Address; Adolescence; Algorithmic Analysis; Anterior; Area; Autopsy; Axon; base; Behavior; Bilateral; Brain; Brain imaging; Brain region; burden of illness; case control; Clinical; Cognition; Cognitive deficits; cognitive function; cognitive testing; Complement; Complex; connectome; Coupled; Data; density; diffusion weighted; Dimensions; disability; disability burden; disorder risk; dysmyelination; Early Diagnosis; emerging adult; experience; experimental study; follow-up; Functional disorder; Gene Expression; Genes; graph theory; healthy volunteer; Histologic; Human; imaging study; improved outcome; indexing; Individual; insight; Insula of Reil; Intervention; Interview; Investigation; Knowledge; Lateral; Link; magnetic field; Magnetic Resonance Imaging; Measurable; Measures; Middle frontal gyrus structure; Modeling; Morphology; Myelin; myelination; neural network; Neurobiology; neurodevelopment; neuroimaging; Neurons; neurophysiology; novel; novel therapeutic intervention; novel therapeutics; Oligodendroglia; Onset of illness; Participant; Pathology; Patients; Pharmaceutical Preparations; Phenotype; Physiological; prevent; Primary Prevention; processing speed; Property; Psychopathology; Psychotic Disorders; psychotic symptoms; recruit; relating to nervous system; Reporting; Reproducibility; Research Domain Criteria; Resolution; response; Risk; Role; Sampling; Scanning; Schizophrenia; secondary analysis; Series; Severities; Severity of illness; Siblings; Speed; Structure; Superior temporal gyrus; support network; Symptoms; System; Testing; theories; Therapeutic Agents; therapy development; Time; ","Brain connectivity and the role of myelin in Psychosis","113619","NPAS","Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section ","","","03","370623","257583","628206",""
"9922117","F32","HD","5","N","03/05/2020","03/27/2020","03/26/2021","865","F32HD098808","SCHOOLS OF MEDICINE","PA-18-670","5F32HD098808-02","NICHD:70146\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","STANFORD","UNITED STATES","NEUROLOGY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943052004","Project Narrative This research aims to advance our understanding of biological pathways related to rehabilitation strategies (i.e. electrical modulation and physical exercise) and stem cells, and their combined therapeutic benefits for improving nerve regeneration and functional recovery in animal models with peripheral nerve injury. The knowledge of how to improve the therapeutic effectiveness of transplanted human neural stem cells (hNSCs) is limited. A better understanding of hNSCs' response to their microenvironment through electrical modulation and physical rehabilitation will provide discoveries and insights on new device approaches and drug candidates for neural recovery and nerve regeneration. These advances will translate into better therapies for patients with peripheral nerve injury.","11083103; ","SONG, SHANG ;","BONNER, JOSEPH FRANCIS","03/27/2019","03/26/2022","Accidents; Acute; Adult; Animal Model; behavior test; Biochemical; bioelectricity; Biological; Biomedical Engineering; Biophysics; Birth; Blood Vessels; Brachial plexus structure; cell behavior; Cell Communication; Cell Differentiation process; Cell Membrane Permeability; Cell Survival; Cells; Child; Childhood; Cicatrix; combat; Complex; cost; Coupled; Cues; cytokine; Defect; Devices; disability; drug candidate; Effectiveness; Electric Stimulation; electrical potential; Electrophysiology (science); Encapsulated; Engineering; Europe; excitotoxicity; Exposure to; Fostering; Goals; Gold; Graft Survival; Harvest; Healthcare Systems; Human; Immune; Immune response; Implant; improved; In Vitro; in vivo; Infiltration; Inflammatory; Inflammatory Response; Injury; injury and repair; insight; Knowledge; Left; Location; Longevity; Mediator of activation protein; Membrane; Methods; Modeling; Molecular Analysis; Motor Vehicles; Muscle; Muscular Atrophy; nanopore; Nature; Nerve; nerve injury; Nerve Regeneration; nerve stem cell; nerve supply; neuromuscular; Neurons; neurotrophic factor; Neurotrophin 3; NTF3 gene; Operative Surgical Procedures; Oxidative Stress; Pathway interactions; Patients; Peripheral nerve injury; peripheral nerve regeneration; Peripheral Nerves; Physical Exercise; Physical Rehabilitation; Population; prevent; Process; Production; Proteins; Rattus; Recovery; Recovery of Function; regenerative; rehabilitation strategy; Rehabilitation therapy; relating to nervous system; release factor; repaired; Research; response; Role; sciatic nerve; Silicon; Site; Spinal; stem cell therapy; Stem cells; Synapses; Techniques; Therapeutic; therapeutic effectiveness; TNF gene; Training; Translating; Transplantation; Trauma; treatment optimization; tumor; vehicular accident; Withdrawal; Work; ","Enhanced Stem Cell Therapy with Rehabilitation Strategies for Peripheral Nerve Regeneration","098808","ZRG1","Special Emphasis Panel ","","","02","70146","","70146",""
"9933185","SC2","GM","1","N","03/23/2020","03/23/2020","01/31/2021","859","SC2GM136500","SCHOOLS OF ARTS AND SCIENCES","PAR-16-438","1SC2GM136500-01","NIGMS:145000\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","NORTHRIDGE","UNITED STATES","BIOLOGY","30","055752331","US","513617","CALIFORNIA STATE UNIVERSITY NORTHRIDGE","CA","913308222","PROJECT NARRATIVE The research direction described herein presents a new strategy to combat bacteria?s ability to adapt to their environment and minimize intake of antibiotics. The biomolecules designed in this work will increase the effectiveness of existing antibiotics and reduce the impact of antibiotic resistant bacteria on public health.","15513306; ","TAKAHASHI, MELISSA K.;","KRASNOVA, IRINA N","03/23/2020","01/31/2023","5' Untranslated Regions; Amino Acids; Antibiotic Resistance; Antibiotic susceptibility; Antibiotics; antimicrobial; antimicrobial drug; Antisense RNA; Arginine; Bacteria; Bacteria sigma factor KatF protein; Bacterial Antibiotic Resistance; Bacteriophage P22; Binding; biological adaptation to stress; Biomedical Research; Cells; Cephalosporins; Code; combat; Combined Modality Therapy; Cytoplasm; design; Development; Effectiveness; efficacy testing; efflux pump; Environment; Environmental Risk Factor; Escherichia coli; Ethnic group; Exposure to; Foundations; Funding; Gammaproteobacteria; Gene Expression; Gene Expression Regulation; Genetic Transcription; Goals; Health; HIV; Human; innovation; insight; Institution; Intake; Klebsiella pneumoniae; Link; locked nucleic acid; Membrane; Membrane Proteins; Methods; novel; Nucleic Acids; OprF protein; Output; Oxidative Stress; pathogen; pathogenic bacteria; Peptide Nucleic Acids; Peptides; Permeability; Pharmaceutical Preparations; Post-Transcriptional Regulation; Predisposition; prevent; Production; Public Health; Race; Randomized; Reaction; Regulation; Reporter; Research; resistance mechanism; Resistance Process; response; RNA; RNA Binding; RNA-Protein Interaction; Salmonella typhimurium; Sampling; sensor; Small RNA; Specificity; Students; System; targeted agent; Testing; Time; training opportunity; Translations; treatment strategy; Untranslated Regions; uptake; Validation; VDAC1 gene; Work; ","Discovering novel antimicrobial agents that target sRNA regulated antibiotic resistance mechanisms","136500","ZGM1","Special Emphasis Panel ","","","01","100000","45000","145000",""
"9939718","U54","MD","5","N","03/18/2020","02/01/2020","01/31/2021","","U54MD007597","","RFA-MD-17-006","5U54MD007597-32","NIMHD:138069\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","WASHINGTON","UNITED STATES","","98","056282296","US","3499801","HOWARD UNIVERSITY","DC","200590005","","9034272; ","KWABI-ADDO, BERNARD ;","","","","Aberrant DNA Methylation; Acetylation; Address; Affect; African American; Alleles; American; bead chip; Behavior; Benign; bioinformatics tool; Biological; Biological Markers; Biology; Cancer Biology; cancer health disparity; cancer initiation; Cancer Patient; Cell Line; cell motility; Clinical; cohort; Data; Data Set; Defect; design; Disease; Disease Progression; DNA; DNA Methylation; Environmental Exposure; Environmental Risk Factor; epigenetic drug; Epigenetic Process; epigenetic therapy; Epithelial Cells; European; Evaluation; experience; expression vector; Family; Gene Chips; Gene Expression; Genes; Genetic; Genetic Predisposition to Disease; Genetic Transcription; Genetic Variation; genome wide methylation; genome-wide; Goals; health disparity; histone methylation; histone modification; Hypermethylation; In Vitro; in vivo; Incidence; Indolent; insight; knock-down; Knock-out; Lead; Life Style; Link; Malignant neoplasm of prostate; men; Messenger RNA; Methylation; methylation pattern; minority health; Mission; mortality; Mutation; Nature; novel; novel strategies; Outcome; overexpression; overexpression analysis; Pathogenesis; Pathologic; Pathway interactions; Patients; Pattern; Phenotype; Play; Populations at Risk; Predisposing Factor; Predisposition; Prevalence; Principal Investigator; Prostate; prostate cancer cell line; prostate cancer risk; Prostate Cancer therapy; pyrosequencing; Recording of previous events; Recurrence; Research; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Role; Sampling; SCID Mice; Small Interfering RNA; Socioeconomic Factors; study population; Testing; The Cancer Genome Atlas; Tissues; Transcript; transcriptome; tumor; Tumor Biology; tumor growth; tumor progression; Universities; Validation; Variant; vector control; Work; Xenograft procedure; ","Epigenetic Regulated Genes in African-American Prostate Cancer Patients","007597","ZMD1","Special Emphasis Panel ","5950","","32","132841","42264","","138069"
"9976825","R21","DK","1","N","03/24/2020","03/25/2020","02/28/2021","847","R21DK124894","SCHOOLS OF MEDICINE","RFA-NS-18-042","1R21DK124894-01","NIDDK:224250\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","TAMPA","UNITED STATES","PHYSIOLOGY","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","Project Narrative There is currently no effective treatment for a large population of patients with gastroesophageal reflux diseases who suffer from chronic heartburn not relieved by acid-suppression therapy. This project is based on novel concepts and innovative genetic strategies and aims to identify the sensory nerve pathway mediating heartburn to enable selective therapeutic targeting of this pathway.","8344500; ","KOLLARIK, MARIAN ;","SHEA-DONOHUE, TEREZ","03/25/2020","02/28/2022","Acids; Address; adeno-associated viral vector; Adult; afferent nerve; Afferent Pathways; Agonist; Anatomy; Area; base; Brain Stem; C Fiber; Capsaicin; Cells; Central Nervous System Agents; Chronic; Clozapine; Conscious; Data; designer receptors exclusively activated by designer drugs; Detection; Direct Costs; effective therapy; Embryo; Esophageal mucous membrane; Esophagus; Esthesia; Exposure to; Facial Expression; Fiber; Ganglia; Gastroesophageal reflux disease; Genetic; Goals; Heartburn; Human; Infusion procedures; innovation; irritation; Knowledge; Label; Location; Lung; Mechanics; Mechanoreceptors; Mediating; Mucous Membrane; Mus; Nerve; nerve supply; Neural Crest; Neurons; Neuropeptide Gene; Nociception; Nociceptors; Nodose Ganglion; novel; novel strategies; novel therapeutics; Office Visits; Oxides; Pain; Pain management; pain sensation; Pathway interactions; patient population; Patients; Perception; Peripheral; Peripheral Nerves; Preparation; Property; Proton Pump Inhibitors; Purinoceptor; Rattus; receptor; recombinase; Reporter; Resistance; Resort; response; Role; selective expression; Sensory; Spinal; Stimulus; Symptoms; TAC1 gene; therapeutic target; Time; TRPV1 gene; United States; Vagus nerve structure; Validation; vector; Viscera; Visceral; Visceral pain; ","Vagal nociceptive pathway mediating pain from the esophagus","124894","ZRG1","Special Emphasis Panel ","","","01","150000","74250","224250",""
"9986026","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007590","","RFA-MD-18-012","5U54MD007590-33","NIMHD:214865\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","ATLANTA","UNITED STATES","","05","065325177","US","2189101","CLARK ATLANTA UNIVERSITY","GA","303144358","PROJECT NARRATIVE This proposed research assembles a team of investigators, utilizes clinical samples and novel cell and animal models and conducts molecular studies to demonstrated a direct link between the YAP/TAZ-NFkB axis and prostate cancer cell migration and metastasis.","11214731; ","CINAR, BEKIR ;","","","","African American; Animal Model; anticancer research; Attenuated; base; Binding; Bioinformatics; Biology; bone; Cancer Cell Growth; Cancer Etiology; cancer health disparity; Cancer Prognosis; cancer stem cell; Cause of Death; Cell Line; Cell model; cell motility; cell stroma; Cells; Cessation of life; Characteristics; chemokine; Chromatin; Clinical; Clinical Research; cohort; Complex; Computer Analysis; Cyclic AMP-Dependent Protein Kinases; cytokine; Development; Disease; Disease Surveillance; disparity reduction; Ectopic Expression; effective therapy; Environment; Etiology; Genes; genetic signature; Genetic Transcription; Goals; Human; improved; In Vitro; in vivo; Incidence; inhibitor/antagonist; insight; Knock-out; Knowledge; Laboratories; Link; Malignant neoplasm of prostate; Malignant Neoplasms; Mediating; Mediator of activation protein; men; Mesenchymal; Metastatic Prostate Cancer; Metastatic to; Molecular; mortality; Neoplasm Metastasis; NF-kappa B; novel; Nuclear; Oncogenes; Oncogenic; Outcome; Pathway interactions; Patient Care; Patient Selection; Patients; Pattern; Play; preclinical study; programs; promoter; Prostate; prostate cancer cell; prostate cancer metastasis; protein complex; Protein Kinase; Proteins; Quality of life; Race; RELA gene; Reporter Genes; Research; Research Personnel; Role; Sampling; Science; Signal Transduction; Stromal Cells; Testing; therapeutic target; Tissues; TNFSF11 gene; Transcription Coactivator; transcription factor; United States; Universities; Variant; ","The YAP/TAZ-Nuclear Factor Kappa B Axis in Prostate Cancer","007590","ZMD1","Special Emphasis Panel ","8342","","33","139567","75366","","214865"
"9986028","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007590","","RFA-MD-18-012","5U54MD007590-33","NIMHD:214402\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","ATLANTA","UNITED STATES","","05","065325177","US","2189101","CLARK ATLANTA UNIVERSITY","GA","303144358","Project narrative The proposed research will investigate how age-related re-growth of prostate epithelial cells initiates and will develop a novel strategy to specifically inhibit this growth event for prostate cancer treatment.","7027023; ","WANG, ZHENGXIN ;","","","","Adult; Age; age related; aged; Aging; Androgen Receptor; anticancer research; Cancer Cell Growth; cancer initiation; cell growth; Cell Nucleus; Cell Proliferation; Chemicals; Cytoplasm; design; Development; Epithelial Cell Proliferation; Epithelial Cells; Event; Goals; Growth; Growth and Development function; inhibitor/antagonist; Knowledge; Laboratories; Lesion; Libraries; Malignant neoplasm of prostate; men; Methyltransferase; Modification; Molecular; mouse model; Mus; novel; novel strategies; Pathologic; Phosphorylation; Premalignant; prevent; Process; Proliferating; Prostate; prostate cancer cell; prostate cancer model; Prostate Cancer therapy; prostate carcinogenesis; prostate enlargement; Prostatic Intraepithelial Neoplasias; Prostatic Neoplasms; protein activation; Protein-Arginine N-Methyltransferase; Proteins; Research; screening; Signal Transduction; Testing; tumor xenograft; Ubiquitination; Universities; Work; ","To Investigate Molecular Mechanisms of Aging-Related Growth of the Prostate - Implications in Prostate Tumorigenesis and Cancer Treatment","007590","ZMD1","Special Emphasis Panel ","8344","","33","139266","75204","","214402"
"9987738","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007582","","RFA-MD-18-012","5U54MD007582-35","NIMHD:787005\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","TALLAHASSEE","UNITED STATES","","05","623751831","US","513802","FLORIDA AGRICULTURAL AND MECHANICAL UNIV","FL","323073105","","6223124; ","SOLIMAN, KARAM F.A.;","","","","Achievement; Address; Advisory Committees; Affect; Area; Basic Science; Behavioral; Behavioral Research; career; Collaborations; community partnership; Data; Development; disadvantaged population; Disease; Educational workshop; Effectiveness; Ensure; Evaluation; experience; Extramural Activities; Faculty; faculty support; Funding; Future; Goals; Health; health disparity; improved; Knowledge; Mentors; Minority; Minority Groups; minority health; Monitor; next generation; novel; Outcome; Program Evaluation; programs; racial health disparity; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Scientist; Services; skills; success; Supervision; symposium; Time; Training; Training Programs; Work; ","Research Program Administration","007582","ZMD1","Special Emphasis Panel ","8125","","35","534962","252043","","787005"
"9987739","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007582","","RFA-MD-18-012","5U54MD007582-35","NIMHD:660244\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","TALLAHASSEE","UNITED STATES","","05","623751831","US","513802","FLORIDA AGRICULTURAL AND MECHANICAL UNIV","FL","323073105","","10519499; ","MOORE, TIMOTHY ;","","","","Address; Antineoplastic Agents; Area; Behavioral Research; Biomedical Research; Biotechnology; Cancer Biology; Collaborations; Communities; Core Facility; cytokine; Data; data management; Development; Drug Delivery Systems; drug discovery; Educational workshop; Epigenetic Process; ethnic minority population; experience; Extramural Activities; Florida; Flow Cytometry; Funding; Goals; graduate student; health disparity; high throughput screening; Image; indexing; Infrastructure; infrastructure development; innovation; innovative technologies; investigator training; Journals; Knowledge; knowledge base; medically underserved population; Methodology; minority scientist; Mission; molecular modeling; new technology; Pilot Projects; programs; Proteomics; Publishing; racial minority; Research; Research Activity; research and development; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Rural; Services; skills; success; Teacher Professional Development; Techniques; Training; training opportunity; United States National Institutes of Health; Universities; Writing; ","Research Infrastructure Core","007582","ZMD1","Special Emphasis Panel ","8126","","35","446111","214133","","660244"
"9987741","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007582","","RFA-MD-18-012","5U54MD007582-35","NIMHD:267426\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","TALLAHASSEE","UNITED STATES","","05","623751831","US","513802","FLORIDA AGRICULTURAL AND MECHANICAL UNIV","FL","323073105","","9226249; ","SUTHER, SANDRA G;","","","","Access to Information; Address; Adoption; African American; AIDS/HIV problem; base; Beauty; Behavior; Behavior Therapy; Breast Cancer Detection; Breast Cancer Early Detection; Cancer Death Rates; cancer diagnosis; cancer health disparity; cancer prevention; cancer risk; cancer therapy; Capital; Cardiovascular Diseases; Censuses; Collaborations; college; Colorectal Cancer; colorectal cancer screening; Communities; community based participatory research; community organizations; Community Outreach; community planning; Complex; County; Death Rate; Depressed mood; Diabetes Mellitus; Diagnosis; Early Diagnosis; Economics; Education; education research; education resources; Educational Activities; Environment; Ethnic group; Event; Family; Florida; follow-up; Fright; General Population; Goals; hands-on learning; Health; health disparity; Health education; Health Fairs; Healthcare Systems; healthy lifestyle; Heavy Drinking; high risk population; high school; Home environment; Incidence; Inequality; Infant Mortality; Information Services; Institution; interest; Intervention; intervention effect; Knowledge; laboratory experiment; malignant breast neoplasm; Malignant neoplasm of lung; Malignant Neoplasms; Mammography; Medical; member; men; Mentors; minority communities; Modeling; mortality; nutrition; Outcome; outreach; Participant; Patient Recruitments; Personal Satisfaction; Pharmacologic Substance; Pharmacy facility; physical inactivity; Population; prevent; preventable death; Public Health; Quality of life; Race; racial and ethnic; racial disparity; real world application; recruit; Research; research data dissemination; Research Personnel; Research Project Grants; Resources; Role; rural counties; Science; Scientist; screening; Screening for cancer; Services; skills; social; State Government; Students; Testing; Tobacco use; Underinsured; underserved minority; Uninsured; Universities; Voice; webinar; Weight; Woman; ","Community Engagement Core","007582","ZMD1","Special Emphasis Panel ","8128","","35","180693","86733","","267426"
"9992183","F32","DE","1","N","02/21/2020","03/25/2020","03/24/2021","121","F32DE029412","SCHOOLS OF DENTISTRY/ORAL HYGN","PA-19-188","1F32DE029412-01A1","NIDCR:70492\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH","","RICHMOND","UNITED STATES","DENTISTRY","04","105300446","US","353201","VIRGINIA COMMONWEALTH UNIVERSITY","VA","232980568","Project Narrative Ferroportin repression occurs in cancers to boost intracellular iron levels needed for their increased proliferation rate. In this proposal we aim to explore the molecular mechanisms of ferroportin repression in head and neck cancer and how this may contribute to tumor progression and metastasis. Successful completion of this project will broaden our understanding of the contribution of iron to head and neck cancers facilitate new therapeutic strategies.","12365010; ","BELVIN, BENJAMIN ROSS;","FRIEDEN, LESLIE A","03/25/2020","03/24/2023","Binding; Binding Sites; Biochemical; Biology; Cancer Biology; Cancer cell line; cancer type; Cell Death; Cell Line; Cell Proliferation; cell type; Cells; Cellular biology; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Data; Disseminated Malignant Neoplasm; Distant; Elements; Endocytosis Induction; Environment; Enzyme-Linked Immunosorbent Assay; experience; Experimental Models; Fellowship; Fibroblasts; Gases; Gingiva; Goals; Growth; Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma; Head Cancer; hepcidin; Homeostasis; Homologous Gene; Hormones; Human; Iron; keratinocyte; knock-down; Life; Light; Lymphoma; Maintenance; malignant breast neoplasm; malignant mouth neoplasm; Malignant neoplasm of lung; Malignant Neoplasms; Measures; Mediating; Membrane; Membrane Proteins; Mentors; metal transporting protein 1; migration; Migration Assay; Modeling; Molecular; Mouth Diseases; Neoplasm Metastasis; new therapeutic target; Normal Cell; novel; novel therapeutic intervention; Oral; Oral cavity; Oral health; Organism; Outcome; Oxidation-Reduction; Pharmaceutical Preparations; Physiology; Plasma; Play; Predisposition; Primary Neoplasm; Process; Production; Property; Proteins; Proteolysis; Reaction; Recombinants; Regulation; Repression; Roentgen Rays; Role; small hairpin RNA; Structural Models; Structure; System; Testing; therapeutic evaluation; therapeutic target; Training; tumor; tumor progression; Work; Xenograft Model; ","Ferroportin Repression in Head and Neck Squamous Cell Carcinoma","029412","ZDE1","Special Emphasis Panel ","","A1","01","70492","","70492",""
"9992638","F31","AI","1","N","03/05/2020","03/05/2020","02/28/2021","855","F31AI152460","SCHOOLS OF MEDICINE","PA-19-195","1F31AI152460-01","NIAID:30773\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAINT LOUIS","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","01","050220722","US","7915401","SAINT LOUIS UNIVERSITY","MO","631032006","The incidence of flavivirus seropositivity can be as high as 100% in certain areas of South America, likely resulting in a substantial number of people having experienced ZIKV infection during the recent epidemic in the context of pre-existing flavivirus immunity. Our preliminary data show that this prior exposure alters the functional capacity of T cells with cross-reactive specificities during ZIKV infection. The proposed study dissects the transcriptional alterations that occur which drive this altered functionality during heterologous infection, how those functional alterations place differential pressure on ZIKV viral swarms within the host, and the implications for pathogenesis.","15769846; ","HASSERT, MARIAH A;","WOODSON, SARA ELAINE","03/05/2020","02/28/2022","Activities of Daily Living; Address; Americas; Animals; Antibodies; antigen-specific T cells; Area; arthropod-borne; B-Lymphocytes; base; Blood Circulation; CD4 Positive T Lymphocytes; CD8-Positive T-Lymphocytes; CD8B1 gene; Cell physiology; Cells; Color; Costs and Benefits; cross reactivity; Culicidae; Cytoplasmic Granules; Data; Dengue; Dengue Virus; Disease; Disease Outcome; Epidemic; Epitopes; experience; Exposure to; Flavivirus; Flavivirus Infections; Generations; Genetic; Genetic Transcription; Geographic Locations; Granzyme; Human; human pathogen; Immune; Immune response; Immune System Diseases; Immunity; Immunologics; immunopathology; improved; in vivo; Incidence; Individual; Infection; Infection Control; Kunjin virus; Mediating; member; Memory; Modeling; mouse model; next generation sequencing; Outcome; pathogen; Pathogenesis; Phenotype; Play; Population; preservation; pressure; Production; programs; research study; response; RNA vaccine; RNA Viruses; Role; secondary infection; seropositive; Serotyping; Shapes; single cell sequencing; South America; Specificity; T cell response; T-Lymphocyte; T-Lymphocyte Epitopes; Testing; Transcription Alteration; Vaccination; Vaccine Design; Vaccines; Viral; Virus; Virus Diseases; West Nile virus; Yellow Fever; Yellow fever virus; Zika Virus; ZIKV disease; ZIKV infection; ","Transcriptional and functional profiling of cross-reactive T cells to understand outcomes for the pathogen and host during heterologous infection","152460","ZRG1","Special Emphasis Panel ","","","01","30773","","30773",""
"9992703","F30","AI","1","N","02/10/2020","02/18/2020","02/17/2021","855","F30AI152342","SCHOOLS OF PUBLIC HEALTH","PA-19-191","1F30AI152342-01","NIAID:50520\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ATLANTA","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","PROJECT NARRATIVE Tuberculosis (TB) is the leading cause of mortality from an infectious disease worldwide, and the spread of the most drug-resistant strains make it a global public health crisis. Recent evidence suggests that it is primarily transmitted through casual contact (brief interactions in the community), however, there exist large gaps in our understanding of where casual contact transmission occurs. This proposal uses epidemiological, biostatistical, and geospatial approaches to better understand transmission dynamics and identify where infections are occurring to effectively target prevention strategies.","14629284; ","HARRINGTON, KRISTIN R.;","MENDEZ, SUSANA","02/18/2020","02/17/2024","Address; Air; Area; Bayesian Method; Bayesian Modeling; Beauty; Biometry; Carbon Dioxide; Categories; Censuses; Cessation of life; Church; Clinic; Cohort Studies; Communicable Diseases; Communities; Country; Data; Data Collection; Dependence; Diagnosis; Dose; Drug resistance; Drug resistance in tuberculosis; Environmental air flow; Epidemic; Epidemiologic Methods; Epidemiology; extensive drug resistance; Extreme drug resistant tuberculosis; Funding; Gaussian model; Generations; Goals; HIV; Home environment; Hour; Household; improved; Incidence; Individual; Infection; infection risk; Infectious Disease Epidemiology; Interruption; Knowledge; Location; Measurement; Measures; Methods; Modeling; Modification; mortality; multidisciplinary; Mycobacterium tuberculosis; Neighborhoods; Notification; novel; pathogen; Patients; Physicians; Population; Population Density; Prevention strategy; Probability; Prospective cohort study; Proxy; Public Health; public health intervention; Reporting; Research; Research Proposals; Research Training; resistant strain; Resources; Risk; Schools; Scientist; Site; skills; South Africa; South African; Structure; Time; Training; transmission process; Tuberculosis; United States National Institutes of Health; Visit; World Health Organization; ","Investigating Transmission Risk and Incidence of Extensively Drug-Resistant Tuberculosis in South Africa","152342","ZRG1","Special Emphasis Panel ","","","01","50520","","50520",""
"10023879","R01","AI","1","N","03/23/2020","03/23/2020","02/28/2021","855","R01AI153025","SCHOOLS OF MEDICINE","PA-19-056","1R01AI153025-01","NIAID:762975\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","DAVIS","UNITED STATES","NONE","03","047120084","US","577503","UNIVERSITY OF CALIFORNIA AT DAVIS","CA","956186153","Narrative Mesenchymal stem/stromal cells (MSC) are anti-inflammatory and immunomodulatory. They have capacity to enhance host immunity and support tissue repair during inflammatory diseases. HIV impairs host immunity and establishes latent reservoirs. This study will investigate the potential of MSCs in enhancing anti-viral mucosal immunity and tissue renewal for viral clearance in the SIV model of AIDS.","1901772; ","DANDEKAR, SATYA ;","POON, BETTY","03/23/2020","02/28/2025","Acquired Immunodeficiency Syndrome; adult stem cell; Allogenic; Animals; Anti-inflammatory; Antibodies; Antigen Presentation; antiretroviral therapy; Antiviral Agents; antiviral immunity; Autologous; Automobile Driving; B-Lymphocyte Subsets; Biological Markers; Cells; Chronic; Clinical Trials; Cytotoxic T-Lymphocytes; Dependovirus; Disease; Disease remission; Environment; Flow Cytometry; Gene Expression; Genes; Gut associated lymphoid tissue; gut microbiota; Gut Mucosa; HIV; HIV Infections; Human; Immune; immune activation; Immune response; Immunity; Immunologics; Immunology; immunoregulation; Impairment; Individual; Inflammation; Inflammatory; inhibitor/antagonist; Injury; innovation; Interruption; Lead; Lymphoid Follicle; Lymphoid Tissue; Macaca; Macaca mulatta; Measures; Mediating; Mesenchymal; metabolomics; Modeling; Molecular; Molecular Analysis; Mucosal Immunity; mucosal site; Mucous Membrane; nonhuman primate; novel; Pathogenicity; Patients; peripheral blood; Quantitative Reverse Transcriptase PCR; Recovery; repaired; response; simian human immunodeficiency virus; Site; SIV; stem; stem cell biology; stem cell therapy; Stem cell transplant; Stem cells; Stromal Cells; Structure; T Virus; T-Lymphocyte; Testing; Therapeutic; therapeutic target; tissue repair; Viral; Viral Load result; Viral reservoir; virology; Virus; Virus Inhibitors; Virus Replication; ","'Corral and Kill' strategy for HIV eradication using MSC in an SIV model","153025","HIVD","HIV Immunopathogenesis and Vaccine Development Study Section ","","","01","499999","262976","762975",""
"10061996","R01","HL","7","N","03/24/2020","03/24/2020","05/31/2020","838","R01HL140839","","PA-18-590","7R01HL140839-03","NHLBI:833289\","Non-SBIR/STTR RPGs","2019","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","PROJECT NARRATIVE Numerous people in the United States are exposed to wood smoke because of forest fires and inefficient household burning stoves. We found that exposure to wood smoke causes reduced lung function and increases the risk for chronic bronchitis, especially in individuals who have a susceptibility gene. Also mice with this susceptibility gene show increased mucin gene expression, especially after exposure to wood smoke. The studies in this proposal will identify the components of WS that increase mucin gene expression and are designed to help develop effective therapies for susceptible individuals who suffer from chronic bronchitis.","1870696; ","TESFAIGZI, YOHANNES ;","PUNTURIERI, ANTONELLO","08/01/2018","05/31/2022","","Wood Smoke and Chronic Mucous Hypersecretion","140839","ZRG1","Special Emphasis Panel ","","","03","507508","325781","833289",""
"10087280","K01","DC","7","N","03/24/2020","08/01/2019","05/31/2020","173","K01DC016339","","PA-18-590","7K01DC016339-03","NIDCD:109891\","OTHER RESEARCH-RELATED","2019","NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS","","PROVO","UNITED STATES","","03","009094012","US","951901","BRIGHAM YOUNG UNIVERSITY","UT","846021001","Project Narrative The majority of people with Autism Spectrum Disorder (ASD) experience difficulties of with auditory, visual, touch, taste, and/or smell stimulation, which can severely decrease quality of life and hinder the development of effective social communication. The current study aims to examine neural function that may contribute to sensory dysfunction and its relationship to communication deficits in ASD. Results of the study stand to increase our general understanding of ASD and provide information that may improve the lives of patients and their families by informing clinical procedures.","10742831; ","CARDON, GARRETT JOSEPH;","RIVERA-RENTAS, ALBERTO L","06/01/2018","05/31/2021","","Neurophysiological and Behavioral Correlates of Sensory and Communication Dysfunction in Children with Autism Spectrum Disorder","016339","CDRC","Communication Disorders Review Committee ","","","03","101751","8140","109891",""
"10099745","R01","DK","3","N","03/26/2020","07/01/2019","06/30/2020","847","R01DK046718","","PA-16-160","3R01DK046718-26S1","NIDDK:66034\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","NARRATIVE  PTH-resistant hypocalcemia is the hallmark of pseudohypoparathyroidism type Ib (PHP1B), a rare imprinting disorder caused by deletions/inversions within GNAS or STX16. In addition to well-establised disease characteristics, previously not recognized clinical and laboratory abnormalities have emerged, including early-onset obesity and congenital hypothyroidism, which may occur even in the absence of mineral ion changes. By identifying novel mutations in GNAS/STX16 or elsewhere in the genome, and by introducing human mutations into clonal cell lines through CRISPR/Cas9, we will explore the mechanisms responsible for parent-specific GNAS methylation and G?s expression.","1858086; ","JUEPPNER, HARALD W.;","MALOZOWSKI, SAUL N","05/01/1993","06/30/2021","Adult; Affect; Alleles; Applications Grants; base; Biochemical; Biological; Birth; Blood Vessels; Brown Fat; Cell Fraction; Cell Line; Characteristics; Child; Clinical; Clone Cells; Complex; Coupled; Cretinism; CRISPR/Cas technology; Data; Defect; Disease; disease-causing mutation; DNA Sequence Alteration; early-onset obesity; Endocrine; Epigenetic Process; Exons; Failure to Thrive; Family; Family history of; Female; Fetal Growth Retardation; Frequencies; Gene Expression; Genes; Genetic; Genome; genome sequencing; GNAS gene; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Hormonal; hormone resistance; Hormones; Human; human disease; Hyperphagia; Hypocalcemia result; imprint; In Vitro; in vitro Model; Inherited; insight; Ions; kindred; Laboratories; Lead; Mediating; Methylation; Minerals; Molecular; Mouse Cell Line; Mus; Mutation; Neurocognitive; novel; Parents; Patients; Physiological; postnatal; Pseudohypoparathyroidism; Pseudopseudohypoparathyroidism; PTH gene; receptor; Resistance; response; RNA Splicing; Rodent; short metacarpals; Site; Syndrome; Transcript; tumor; Uniparental Isodisomies; Variant; whole genome; ","Molecular definition of pseudohypoparathyroidism","046718","MCE","Molecular and Cellular Endocrinology Study Section ","","S1","26","39306","26728","66034",""
"10124792","R01","DK","7","N","03/25/2020","07/02/2019","04/30/2020","847","R01DK113504","","PA-16-188","7R01DK113504-04","NIDDK:231816\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","WASHINGTON","UNITED STATES","","98","143983562","US","1518602","CHILDREN'S RESEARCH INSTITUTE","DC","200102916","Painful bladder syndromes affect up to 40% of some patient populations and effective therapies do not exist for many of these people. We propose to exploit a parasite-derived protein, IPSE, as a candidate therapeutic due to its ability to modulate host immune and non-immune responses to bladder injury. We hypothesize that IPSE can be optimized for therapeutic potential (while minimizing toxicity) through the generation of mutant forms with altered ability to modulate host responses via three distinct mechanisms: IL-4-binding, chemokine-binding, and nuclear localization.","9958935; ","HSIEH, MICHAEL HARRISON;","BAVENDAM, TAMARA G","05/05/2017","04/30/2022","","Therapeutic Exploitation of IPSE, a Urogenital Parasite-Derived Host Modulatory Protein, for Bladder Hypersensitivity Syndromes","113504","ZRG1","Special Emphasis Panel ","","","04","132874","98942","231816",""
"10130069","UM1","AI","3","N","03/26/2020","03/26/2020","11/30/2020","855","UM1AI148689","SCHOOLS OF MEDICINE","RFA-AI-18-046","3UM1AI148689-01S1","NIAID:319589\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BALTIMORE","UNITED STATES","PEDIATRICS","07","188435911","US","820104","UNIVERSITY OF MARYLAND BALTIMORE","MD","212011508","Project Narrative Advancing vaccines, treatments, and other tools for preventing and controlling endemic, epidemic and emerging infectious diseases that threaten health and well-being is a top NIAID and public healthy priority. In its capacity as a longstanding and accomplished VTEU, the University of Maryland Center for Vaccine Development and Global Health (CVD) proposes to harness our innovation, technical capacity, in-depth subject matter expertise, and broad network of domestic and international collaborators to achieve program goals. We will work collaboratively with VTEU sites and leadership to identify and implement the highest quality clinical research across NIAID priority areas, while mentoring and developing the next generation of clinical scientists.","2419191; ","KOTLOFF, KAREN L.;","LEE, MARINA","12/11/2019","11/30/2020","Address; Advisory Committees; age group; Ambulatory Care; Area; Award; base; Biological; Biological Response Modifier Therapy; chikungunya; Clinic; Clinical; Clinical Protocols; Clinical Research; clinical research site; Clinical Trials; cohesion; collaborative approach; Communicable Diseases; Communities; Complement; Consultations; Contracts; cost; Country; Data; design; Development; Devices; Diagnosis; Diagnostic; Disease; Disease Outbreaks; dosage; Drug Kinetics; Ebola virus; Emerging Communicable Diseases; Enrollment; Enteral; Epidemic; epidemiology study; Equipment; ethnic diversity; Evaluation; Evaluation Studies; experience; Faculty; first-in-human; flexibility; Formulation; Funding; global health; Goals; Government; Guidelines; Health; healthy volunteer; Hospitalization; Human; Human Resources; human subject; Immune response; improved; Infection; Influenza; Infrastructure; innovation; Inpatients; interest; International; Intervention; Intervention Trial; Investigation; Laboratories; laboratory facility; Laws; Leadership; Malaria; Maryland; Medical Device; medical schools; Mentors; Methods; microbiota; Modeling; National Institute of Allergy and Infectious Disease; neglected tropical diseases; next generation; novel; novel diagnostics; organizational structure; Outpatients; Participant; pathogen; patient population; Patients; Performance; Personal Satisfaction; Pharmaceutical Preparations; Phase; Policies; Population; pre-clinical; predictive marker; prevent; Prevention; Preventive; product development; Prognostic Marker; Program Development; programs; Protocols documentation; Public Health; public health emergency; Public Policy; Publishing; racial diversity; Reagent; Regulation; Reporting; Research; Research Design; Research Personnel; Research Priority; Research Subjects; Resources; Respiratory Tract Infections; response; Risk; sample collection; Sampling; Schedule; Scientist; Services; Sexually Transmitted Diseases; Site; skills; Source; study population; Surveys; System; Systems Biology; targeted delivery; Therapeutic; therapeutic vaccine; tool; Training; United States National Institutes of Health; Universities; vaccine candidate; vaccine development; vaccine evaluation; Vaccines; volunteer; Work; Zika Virus; ","Implementing Vaccine and Treatment Evaluation Unit (VTEU) clinical site protocols","148689","ZAI1","Special Emphasis Panel ","","S1","01","206854","112735","319589",""
"10130750","UM1","AI","3","N","03/24/2020","03/24/2020","11/30/2020","855","UM1AI148450","SCHOOL OF MEDICINE & DENTISTRY","RFA-AI-18-046","3UM1AI148450-01S1","NIAID:270156\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ROCHESTER","UNITED STATES","INTERNAL MEDICINE/MEDICINE","25","041294109","US","7047101","UNIVERSITY OF ROCHESTER","NY","146270140","The University of Rochester Vaccine and Treatment Evaluation Unit (VTEU) will offer a highly diversified team of investigators experienced in collaborative research and a site with the necessary scientific, clinical, administrative and organizational structure to support NIAID clinical research initiatives to evaluate methods for the treatment and prevention of infectious diseases. Our research capabilities will also provide the VTEU network with a variety of cutting edge technologies to interrogate the host response and develop a deeper understanding of the pathogenesis for many infectious diseases.","12021719; 1947253 (contact); ","BRANCHE, ANGELA RAMONA; FALSEY, ANN R (contact);","LEE, MARINA","12/11/2019","11/30/2026","Address; Adult; Age; Antibiotic-resistant organism; Antibiotics; Area; Biological Response Modifier Therapy; Categories; Child; Childhood; Cities; Clinic; Clinical; Clinical Research; clinical research site; Clinical Trials; combat; Communicable Diseases; Communities; County; Data; Data Analyses; data management; design; Development; Devices; Diagnostic; Disease; Disease Outbreaks; Drug Kinetics; drug resistant bacteria; Education; Elderly; Enrollment; Ensure; Enteral; Evaluation; experience; Faculty; fight against; flexibility; Genetic Transcription; Good Clinical Practice; Happiness; Health; Health Personnel; Hospitals; Human Resources; Immune response; Immunization; Immunology procedure; improved; Infant; Infection; Influenza; innovation; Intervention; Investigation; Laboratories; Laboratory Research; Leadership; Malaria; Measles; Methods; microbiome analysis; Multi-Drug Resistance; Multi-Institutional Clinical Trial; Multicenter Trials; Mumps; National Institute of Allergy and Infectious Disease; next generation; novel; novel therapeutics; novel vaccines; organizational structure; pathogen; Pathogenesis; Patients; Pertussis; Pharmacy facility; Phase; Physicians; Policies; Poliomyelitis; Positioning Attribute; pre-clinical research; predictive marker; Pregnant Women; premature; Preparation; preservation; Prevention; Preventive; Procedures; Protocols documentation; recruit; Reporting; Research; Research Personnel; Resources; respiratory; Risk; Sampling; Scientist; Secure; Sexually Transmitted Diseases; Site; Surgeon; Target Populations; Technology; Testing; Therapeutic; Time; Training; Tuberculosis; United States; United States National Institutes of Health; Universities; Vaccination; vaccine evaluation; Vaccines; Virus; Vulnerable Populations; War; Work; young adult; young woman; ","University of Rochester Vaccine and Treatment Evaluation Unit (VTEU)","148450","ZAI1","Special Emphasis Panel ","","S1","01","175426","94730","270156",""
"10131543","P20","GM","1","N","03/25/2020","03/15/2020","02/28/2021","","P20GM130420","","PAR-18-266","1P20GM130420-01A1","NIGMS:203183\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","COLUMBIA","UNITED STATES","","06","041387846","US","1524302","UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA","SC","292080001","","14783116; ","ARMSTRONG, BRIDGET R.;","GAO, HONGWEI","","","5 year old; Accelerometer; Address; Adult; Behavior Therapy; behavioral health; cardiovascular risk factor; Caregivers; Centers of Research Excellence; Child; Child Behavior; Child Rearing; Child Welfare; Data; Devices; early childhood; Ecological momentary assessment; Emotional; emotional behavior; Family Process; Fibrinogen; Habits; handheld mobile device; Health; Health behavior; health disparity; Intervention; Interview; Link; Low income; Measurement; Measures; Mental Depression; Mental Health; Methodology; mobile computing; Obesity; obesity risk; obesogenic; Outcome; Parents; Patient Self-Report; Personal Satisfaction; physical conditioning; prevent; Problem behavior; Process; Protocols documentation; Reporting; Research; Risk Factors; School-Age Population; Science; sedentary lifestyle; Sleep; sleep behavior; Sleep disturbances; social; Source; Stress; Substance abuse problem; Testing; Time; time use; tv watching; ","Microtemporal Family Processes Underlying Preschoolers' Screen Time and Behavioral Health","130420","ZGM1","Special Emphasis Panel ","5272","A1","01","136364","66819","","203183"
"9695870","I01","VA","5","N","03/27/2020","05/01/2019","04/30/2020","999","I01HX002362","","RFA-HX-17-001","5I01HX002362-02","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","PALO ALTO","UNITED STATES","","18","046017455","US","481014","VETERANS ADMIN PALO ALTO HEALTH CARE SYS","CA","943041207","This is an opportunity to critically examine access to emergency care within the VA and foster organizational improvement of the emergency care system. Emergency care access is particularly problematic for Veterans, in part because VA emergency departments (ED) are far and few between, and Veterans are often uncertain where to go when confronted with an emergency. This is particularly true for Veterans with special access issues, like those living in rural areas, those lacking housing, and women. We will assess capabilities and resources of VA EDs to care for acutely ill Veterans. Further, by analyzing ED data and speaking with Veterans, we will better understand where and why Veterans access the emergency care system (in both VA and non-VA settings) and will identify barriers in access amendable in future intervention and policy changes. Ultimately, our results are highly actionable to our operational partners and can be directly used to improve access to emergency care for Veterans during times of crisis.","11344073; ","VASHI, ANITA A;","","05/01/2018","04/30/2021","Accident and Emergency department; Accounting; Acute; Address; Advocate; Ambulatory Care Facilities; Area; base; Bypass; California; care seeking; care systems; Caring; Chest Pain; Chronic; cohort; Communities; Complex; contextual factors; cost; Country; Data; Data Analyses; Decision Making; design; Eligibility Determination; Emergency Care; Emergency department visit; Emergency Medicine; Emergency Situation; Enrollment; Ensure; Equipment and supply inventories; experience; Failure; Family; Fostering; Funding; Future; Gender; Glare; Government; Gunshot wound; Health; health care availability; health care service; Health Services Accessibility; Health system; Healthcare; Healthcare Systems; Home environment; Housing; Improve Access; improved; Infrastructure; innovation; Institute of Medicine (U.S.); Insurance; Intervention; Interview; Knowledge; Medical emergency; Medicare; Methods; Myocardial Infarction; Outcome; Patients; Phase; Policies; Population; preference; prevent; Primary Health Care; Provider; Qualitative Methods; Quality of Care; Reporting; Research; Resources; rural area; rurality; safety net; service organization; Services; Structure; Surveys; System; Time; Translating; United States; Variant; Veterans; Visit; Wife; Woman; Work; ","Veteran Access to Emergency Care","002362","HSR5","HSR-5 Health Care System Organization and Delivery ","","","02","","","",""
"9816583","I21","VA","5","N","03/24/2020","01/01/2020","12/31/2020","999","I21RX003019","","RFA-RX-18-012","5I21RX003019-02","","RESEARCH CENTERS","2020","Veterans Affairs","","BRONX","UNITED STATES","","13","040077133","US","481060","JAMES J PETERS VA  MEDICAL CENTER","NY","104683904","Blast exposure is associated with a variety of mental health related problems in veterans including post-­ traumatic stress disorder (PTSD). The proposed research will test whether transcranial photobiomodulation  therapy can improve the chronic anxiety and PTSD-­related behavioral traits observed in blast-­exposed rats  while ameliorating the underlying vascular pathology. The findings of this research may be used to develop  new therapeutic strategies for the treatment of veterans affected by blast-­related brain injury. ","8219765; ","ELDER, GREGORY A.;","","01/01/2019","12/31/2020","Acoustics; Acute; Affect; Afghanistan; Alzheimer's Disease; Animal Model; Animal Testing; Animals; Anxiety; ATP Synthesis Pathway; attenuation; Behavioral; Biochemistry; Blast Injuries; Blood Vessels; Brain Injuries; Cerebrovascular system; Chronic; Chronic Post Traumatic Stress Disorder; Cognitive; Collaborations; Conflict (Psychology); Cues; Department of Defense; Exhibits; Exposure to; Fright; Goals; Histopathology; Homeostasis; human model; improved; Injury; Iraq; Lasers; Light; Low-Level Laser Therapy; Major Depressive Disorder; Measures; Mental Depression; Mental disorders; Mental Health; Metabolic; microCT; mild traumatic brain injury; Military Personnel; Mitochondria; Modality; Modeling; Morbidity - disease rate; mortality; nervous system disorder; Neurons; Nitric Oxide; novel therapeutic intervention; novel therapeutics; Optics; Oxygen Consumption; Parkinson Disease; Pathology; persistent symptom; Phenotype; photobiomodulation; Pilot Projects; Play; Post-Traumatic Stress Disorders; Production; Rattus; Research; Research Personnel; response; Role; Scanning; Services; stress related disorder; Stroke; Supportive care; Testing; Therapeutic; Time; trait; Traumatic Brain Injury; treatment strategy; Veterans; Work; ","Transcranial photobiomodulation therapy for treatment of blast-induced traumatic brain injury: A pilot study in a rat model of primary blast","003019","RRDS","Rehabilitation Research and Development SPiRE Program ","","","02","","","",""
"9841177","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:196198\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE The Data Management and Analysis Core (DMAC) of the University of Kentucky Superfund Research Center (UK-SRC) provides an integral new resource by functioning as a nexus for interactions across projects and cores. It systematically integrates data assets through the entire lifecycle of the grant and facilitates interaction of investigators and trainees to assist them in conducting research that addresses Superfund mandates. The DMAC will foster data sharing within and beyond UK-SRC, including researchers, as well as community stakeholders, and governmental agencies committed to protecting public health from the adverse effects of hazardous chemicals.","8776790; ","PENNELL, KELLY G;","","","","Academy; Address; Adverse effects; Animals; application programming interface; Awareness; base; Basic Science; biomedical informatics; Biometry; Chemicals; Collaborations; Common Data Element; Communities; Complex; Computational Science; Consensus; dashboard; Data; Data Analyses; data archive; data centers; data ecosystem; data integration; data management; Data Quality; data resource; Data Science; Data Scientist; Data Set; data sharing; data tools; Deposition; design; Development; Dictionary; Discipline; Documentation; E-learning; Ecology; Educational workshop; Ensure; Environment; Environmental Health; experience; experimental study; Formulation; Fostering; Gap Junctions; Goals; Government Agencies; Grant; Hazardous Chemicals; Hazardous Substances; improved; Information Resources; Infrastructure; innovation; Interdisciplinary Study; interoperability; Investigator-Initiated Research; Kentucky; Knowledge; Knowledge Discovery; Life Cycle Stages; meetings; member; Metadata; Methods; National Institute of Environmental Health Sciences; nutrition; Online Systems; Ontology; Outcome; Planet Earth; Population; Problem Solving; Process; programs; Protocols documentation; Public Health; quality assurance; Quality Control; Registries; remediation; repository; Reproducibility; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk; Science; Scientist; Secure; Series; Site; Standardization; Superfund; superfund chemical; symposium; Technology; Terminology; Testing; tool; Toxic effect; Training; training opportunity; training project; Translational Research; Universities; Validation; webinar; Work; ","Data Management and Analysis Core","007380","ZES1","Special Emphasis Panel ","5737","","22","135309","60889","","196198"
"9841178","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:113100\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE  The Community Engagement Core (CEC) works to achieve public health benefits within communities and  supports the UK-SRC by encouraging Superfund Research Program (SRP) stakeholders to protect their health  from exposure to environmental contaminants by consuming a healthy diet and increasing physical activity to  reduce the bodily amount and toxicity of hazardous substances (mandate #4). The proposed CEC prevention/  intervention activities are community-driven, solution-oriented programs that translate the science of the UK-  SRC and addresses the needs of SRP stakeholders with concerns regarding exposure to hazardous  substances. The CEC programs achieve this by providing community residents with the opportunity to improve  nutrition, increase physical activity and enhance environmental health literacy among community residents.","12559398; ","BREWER, DAWN ;","","","","Address; Adopted; Affect; Age; Air Pollution; Area; Back; Behavior; behavior change; Biological; Chemicals; Chronic Disease; Coal Mining; Collaborations; Communication; Communities; community center; community organizations; Consumption; Country; County; design; Development; Drug Metabolic Detoxication; Education; Elderly; environmental change; Environmental Hazards; Environmental Health; Environmental Pollutants; Environmental Pollution; Evaluation; evidence base; experience; Exposure to; Family; farmers markets; Focus Groups; Fostering; Goals; good diet; Hazardous Substances; Health; Health behavior; Health behavior change; Health Benefit; health knowledge; health literacy; healthy lifestyle; Home environment; improved; Individual; innovation; Intervention; Interview; Journals; Kentucky; Kidney; Knowledge; Lead; Life Style; Liver; Longevity; meetings; Methods; Modeling; Needs Assessment; novel; nutrition; Outcome; Peer Review; Physical activity; Physiological; Plants; Policies; pollutant; Polychlorinated Biphenyls; Population; Population Growth; Populations at Risk; prevent; Preventive Intervention; programs; Public Health; rapid growth; Recommendation; Reporting; Research; Research Activity; Research Project Summaries; Resources; Risk; Science; Scientist; Services; Site; social; Solvents; Superfund; superfund chemical; superfund site; Surveys; symposium; System; tool; tool development; Toxic effect; Translating; United States; Universities; walking program; Water Pollution; Work; Youth; ","Community Engagement Core","007380","ZES1","Special Emphasis Panel ","5738","","22","78000","35100","","113100"
"9841182","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:209400\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE The persistence of toxic pollutants at Superfund sites poses a major environmental public health problem and a serious need for environmental solutions to reduce risk. Our research is expected to lead to cost-effective technologies for remediation of chemicals, such as TCE, PCE and PCBs, to nontoxic and biodegradable intermediates and for superfast sorption of PFAS compounds with responsive polymer materials. Our approaches to develop new polymer membrane and 2D-based materials to detoxify water and low energy consuming adsorption/desorption technologies should lead to an advanced technology solution in the field of remediation science and engineering from Superfund sites to water utility companies.","8534525; ","BHATTACHARYYA, DIBAKAR ;","","","","Adsorption; Advanced Development; Aftercare; Area; Attention; base; Biomedical Research; Carbon; Carbon Tetrachloride; Catalysis; Catalytic Domain; Chemicals; Chloroform; Collaborations; Consumption; contaminated water; cost; cost effective; design; Detection; Development; drinking water; Drug Metabolic Detoxication; Engineering; Environment; Environmental Health; Fiber; food science; Funding; Gel; global environment; Goals; graphene; ground water; Hazardous Waste Sites; Health; Heating; Human; Hydrogels; Individual; Industrialization; International; Iron; Kentucky; Lead; magnetic field; Magnetism; magnetite ferrosoferric oxide; materials science; Membrane; Metals; Methods; microbial; nanocomposite; nanoparticle; nanoscale; nanosized; Nanostructures; Natural regeneration; novel; nutrition; Nutritional Science; Oxidants; Oxides; particle; pollutant; Polychlorinated Biphenyls; Polymers; prevent; Property; Public Health; reaction rate; remediation; Research; Risk; Science; sensor; Site; Soil; Solvents; Source; Sulfate; Superfund; superfund chemical; superfund site; Surface; System; Techniques; Technology; Temperature; Tetrachloroethylene; Toxic effect; Toxicant exposure; Trichloroethylene; Water; water sampling; ","Responsive Membranes and Advanced Materials for Sensing and Remediation of Halo-organics","007380","ZES1","Special Emphasis Panel ","5742","","22","144414","64986","","209400"
"9841183","P42","ES","2","N","03/26/2020","12/01/2019","11/30/2020","","P42ES007380","","RFA-ES-18-002","2P42ES007380-22","NIEHS:188400\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","LEXINGTON","UNITED STATES","","06","939017877","US","2793601","UNIVERSITY OF KENTUCKY","KY","405260001","PROJECT NARRATIVE The overarching goal of this project is to advance fate and transport research to identify and reduce exposure risks associated with trichloroethene (TCE), tetrachloroethene (PCE), and PFAS. Field study results verify and calibrate new models that predict contaminant mass flux associated with damaged subsurface piping networks, which serve as preferential pathways for contaminants to be transported throughout communities. Evidence- based practices serve as a framework to promote environmental health literacy, so that community stakeholders, representatives from regulatory agencies, and industry groups can provide information to develop solutions that will ensure Superfund mandates are addressed and public health is protected.","8776790; ","PENNELL, KELLY G;","","","","Address; aged; Aging; Air; Analytical Chemistry; base; Biological Monitoring; Biomedical Research; California; Communication; Communities; Computer Models; contaminant transport; Coupled; Data; Data Analyses; data management; data modeling; data interoperability; Deterioration; drinking water; Ecology; engineering design; Ensure; Environment; Environmental air flow; Environmental Engineering technology; Environmental Exposure; Environmental Hazards; Environmental Health; Environmental Pollution; epidemiology study; Equation; Ethylenes; Evidence based practice; field study; Foundations; Fracture; Gases; Goals; ground water; Hazardous Waste; Health; health literacy; hookah; Human; Individual; Indoor Air Quality; Industry; informant; Infrastructure; Inhalation Exposure; Interview; Joints; Kentucky; Knowledge; mass flux; Measurement; Measures; Membrane; Modeling; North Carolina; novel; nutrition; Outcome; Outcome Study; Pathway interactions; Policies; Polymers; predictive modeling; pressure; prevent; Public Health; Regulation; Reporting; Research; research facility; Research Project Grants; Risk; Risk Reduction; Route; Sampling; Science; sensor; sensor technology; Services; Site; Superfund; superfund chemical; superfund site; Surveys; System; Techniques; Temperature; Testing; Tetrachloroethylene; Time; tool; Toxic effect; Transcend; Translational Research; Transport Process; Trichloroethylene; Uncertainty; United States; vapor intrusion; Volatilization; Water; water quality; Water Supply; ","Fate and Transport of Contaminants in Aging Piping Systems","007380","ZES1","Special Emphasis Panel ","5743","","22","131793","56607","","188400"
"9854061","P30","CA","2","N","03/25/2020","12/01/2019","11/30/2020","","P30CA034196","","PAR-17-095","2P30CA034196-34","NCI:49109\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","BAR HARBOR","UNITED STATES","","02","042140483","US","7096501","JACKSON LABORATORY","ME","046091500","","6488561; ","PALUCKA, ANNA KAROLINA ;","","","","Abbreviations; Adverse effects; Animal Model; anticancer research; Antigen-Presenting Cells; Area; Basic Science; behavioral response; Biological; Biological Markers; Biological Models; Biological Process; biological systems; Budgets; Cancer Biology; cancer cell; Cancer Center; Cancer Center Support Grant; cancer genomics; Cancer Model; cancer therapy; Cancer Vaccines; candidate marker; Cell model; chemotherapy; Chromosomal Rearrangement; Cities; Clinical; Collaborations; Complement; Complex; Computational algorithm; Computational Science; Computer Models; Computing Methodologies; computing resources; Connecticut; Core Grant; Data Set; design; Development; Direct Costs; Discipline; DNA Damage; DNA Repair Pathway; DNA Sequence Alteration; Evolution; Extracellular Matrix; Faculty Recruitment; Fostering; Foundations; functional genomics; Funding; Future; Genetic; Genetic Engineering; Genetic Models; genetic regulatory protein; genetic resource; Genetic Variation; Genome; genomic aberrations; Genomic Instability; Genomics; Goals; Grant; Health; Human Genetics; Immune checkpoint inhibitor; Immunodeficient Mouse; Immunologics; Immunotherapy; in vitro Model; in vivo; in vivo Model; innovation; innovative technologies; Investigation; Israel; Knowledge; Laboratories; Lead; Leadership; Maine; Malignant Neoplasms; Mediator of activation protein; Medical center; Medicine; meetings; member; Methods; model development; Modeling; Mus; Mutation; Names; NCI Center for Cancer Research; neoplastic cell; new technology; novel; Oncogene Activation; Output; Patients; Pediatric Hospitals; Peer Review; Phenotype; precision medicine; precision oncology; programs; Property; Publications; Records; Research; Research Personnel; Research Project Summaries; Research Support; Resistance; resistance mechanism; Resource Development; Resources; response; Sampling; single cell technology; Southwest Oncology Group; Structure; System; technological innovation; Technology; Telomere Maintenance; The Jackson Laboratory; therapeutic target; therapy resistant; Travel; treatment response; tumor; tumor microenvironment; Tumor Suppressor Proteins; Tumorigenicity; United States National Institutes of Health; Universities; Vision; Work; Xenograft procedure; ","Research Program","034196","NCI","Subcommittee H - Clinical Groups ","7975","","34","28314","20795","","49109"
"9865734","R01","HD","1","N","03/23/2020","03/23/2020","02/28/2021","865","R01HD100518","SCHOOLS OF MEDICINE","PA-19-056","1R01HD100518-01","NICHD:351713\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","NEW YORK","UNITED STATES","ANATOMY/CELL BIOLOGY","13","078861598","US","3839801","ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI","NY","100296574","PROJECT NARRATIVE Retrotransposons can seriously damage the genome of the nascent embryo and cause sporadic diseases and infertility. Here we will explore a new sensing mechanism that involves early embryonic cells ?sniffing? one another for endogenous retroviruses and the removal of cells that failed to silence their genetic parasites. Our line of investigation will provide new targets for genetic diagnosis and interventions targeting pregnancy loss, birth defects and childlessness.","7691607; ","ZWAKA, THOMAS P.;","RAVINDRANATH, NEELAKANTA","03/23/2020","02/28/2025","Address; Apoptosis; arm; Attention; base; blastomere structure; Cell Communication; Cell Cycle Arrest; Cells; Chromatin; Code; Congenital Abnormality; Data; Defect; defense response; Development; Disease; DNA; DNA Damage; DNA Methylation; Double-Stranded RNA; early pregnancy; early pregnancy loss; Elements; Embryo; Embryonic Development; embryonic stem cell; Endogenous Retroviruses; Epiblast; Excision; Exogenous Factors; experimental study; Fossils; gene therapy; Genetic; genetic disorder diagnosis; Genome; Goals; Grant; Growth; Health; Immune; Immune system; immunoregulation; Infertility; Investigation; Length; Monitor; Mus; Normal tissue morphology; novel; Nucleic Acids; Outcome; Parasites; peer; Phagocytosis; Physiology; Play; Pluripotent Stem Cells; Police; Pregnancy loss; Process; Proteins; Race; Repetitive Sequence; replicator; Research Proposals; response; Retrotransposon; Risk Factors; Role; sensor; Specific qualifier value; Stress; stress granule; System; Testing; tissue culture; TP53 gene; transposon/insertion element; Untranslated RNA; Viral load measurement; viral RNA; Virion; Virus; Work; Zinc Fingers; ","Protection of early embryogenesis and pluripotent stem cells against genetic parasites through a primitive immune system","100518","DEV2","Development - 2 Study Section ","","","01","207500","144213","351713",""
"9869944","R01","NS","5","N","03/25/2020","03/01/2020","02/28/2021","853","R01NS105756","SCHOOLS OF MEDICINE","PA-16-160","5R01NS105756-03","NIA:46657\NINDS:326601\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","PITTSBURGH","UNITED STATES","BIOLOGY","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","Nearly all Amyotrophic Lateral Sclerosis patients exhibit a common neuropathology in the form of cytoplasmic TDP-43 inclusions. While the mechanistic cause of TDP-43 proteinopathy is unclear, studies suggest abnormal stress granule homeostasis is involved. This proposal will utilize a novel optogentic approach to induce TDP-43 inclusions or light induced functional stress granules, to investigate the interplay between TDP-43 proteinopathy and stress granule flux.","12346091; ","DONNELLY, CHRISTOPHER JAMES;","GUBITZ, AMELIE","03/15/2018","02/28/2023","Address; ALS patients; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Autopsy; Biological Models; Brain; Cell Nucleus; Cell physiology; Cells; Cellular Stress; Chronic; Chronic stress; chronic traumatic encephalopathy; Cytoplasm; Cytoplasmic Inclusion; cytotoxic; Development; Diagnosis; Disease; DNA Sequence Alteration; DNA-Binding Proteins; Exhibits; experimental study; extracellular; Family; Family history of; Frontotemporal Dementia; frontotemporal lobar dementia-amyotrophic lateral sclerosis; Functional disorder; functional loss; Genes; Genetic; genome-wide; Heterogeneity; Homeostasis; Human; Impairment; induced pluripotent stem cell; insight; Interneurons; Light; Link; Literature; Mediating; Methods; Modeling; motor neuron degeneration; Motor Neurons; mutant; Mutation; nervous system disorder; Nervous system structure; Neurodegenerative Disorders; Neurons; neuropathology; neurotoxic; neurotoxicity; novel; Nuclear RNA; Onset of illness; optogenetics; Organelles; overexpression; Pathogenesis; Pathogenicity; Pathologic; Pathway interactions; Patients; Play; prevent; Process; Protein Biosynthesis; Protein Conformation; protein TDP-43; Proteins; Recording of previous events; Regulation; RNA interference screen; RNA Processing; Seeds; Spinal Cord; stress granule; stressor; System; Tissues; Toxic effect; ","An optogenetic approach to establish the interplay between stress granules and TDP-43 proteinopathy in ALS/FTD","105756","CMND","Cellular and Molecular Biology of Neurodegeneration Study Section ","","","03","250000","123258","373258",""
"9872135","R01","CA","5","N","03/26/2020","03/01/2020","02/28/2021","395","R01CA226776","","PA-16-160","5R01CA226776-03","NCI:400313\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","BOSTON","UNITED STATES","","07","071723621","US","758101","BETH ISRAEL DEACONESS MEDICAL CENTER","MA","022155400","Narrative Our proposal addresses the problem of advanced, PIK3CA-mutant breast cancer. We propose a role for PI3K-inhibitors in this disease at a stage when the disease no longer responds to endocrine manipulation, cdk4/6- or mTOR-inhibition and when patients typically receive palliative chemotherapy. We propose a role for next-generation PI3K-inhibitors at later stages of the disease, when PIK3CA-mutant tumors have developed endocrine, cdk4/6i and mTORi resistance. In three independent aims our goal is to develop treatment strategies for women with endocrine-resistant PIK3CA mutant breast cancer. Metabolic imaging will be used to advance that goal. Understanding the distinct anti-metabolic function of PI3Ki that are active in heavily pretreated disease will allow us to develop combination treatments and administration schedules that can be translated into clinical trials concepts.","3124175; ","WULF, GERBURG M;","CHEN, WEIWEI","03/01/2018","02/28/2023","Address; Adopted; Advanced Malignant Neoplasm; Aldehyde-Lyases; Aldolase A; Antineoplastic Agents; arm; Avidity; Binding; Breast Cancer Cell; cancer cell; cancer therapy; carbohydrate metabolism; Cell division; Cell Line; Cells; Cessation of life; chemotherapy; Clinical; Clinical Trials; comparative; Cytoskeleton; Data; Detection; Disease; Drops; Endocrine; Enzymes; Estrogen receptor positive; Estrogen Receptor Status; Estrogen Receptors; fluorodeoxyglucose; G2/M Arrest; Glucose; glucose metabolism; Glycolysis; Goals; improved; improved outcome; In Vitro; in vivo; Infusion procedures; inhibitor/antagonist; Lead; Link; malignant breast neoplasm; Mammary Neoplasms; Metabolic; metabolic imaging; Metastatic breast cancer; Mitotic; Modernization; mouse model; mTOR inhibition; mutant; Mutate; Mutation; neoplastic cell; next generation; novel; nucleotide metabolism; palliative chemotherapy; Pathway interactions; Patients; Pentosephosphate Pathway; Pharmaceutical Preparations; Phase; PIK3CA gene; Positron-Emission Tomography; predictive marker; Predictive Value; Predictive Value of Tests; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyruvate; Pyruvate Metabolism Pathway; Receptor Inhibition; receptor sensitivity; Receptor Signaling; recruit; Refractory; Resistance; resistance mechanism; response; Role; Schedule; Signal Pathway; Signal Transduction; standard of care; taxane; Time; Translating; Treatment outcome; treatment response; treatment strategy; triple-negative invasive breast carcinoma; tumor; tumor metabolism; Vinca Alkaloids; Warburg Effect; Woman; Work; ","Novel Uses of PI3K-inhibitors for the Treatment of advanced PIK3CA-mutant Breast Cancer","226776","BMCT","Basic Mechanisms  of Cancer Therapeutics Study Section ","","","03","228750","171563","400313",""
"9884797","R03","HD","5","N","03/23/2020","03/01/2020","02/28/2021","865","R03HD097425","SCH OF BUSINESS/PUBLIC ADMIN","PA-18-488","5R03HD097425-03","NICHD:75500\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","ATHENS","UNITED STATES","MISCELLANEOUS","10","004315578","US","676602","UNIVERSITY OF GEORGIA","GA","306021589","RELEVANCE FOR PUBLIC HEALTH: Hundreds of millions of children are undernourished in low- and middle-income countries. Little is known about the relations between household income around birth and early childhood health. Contributing to this knowledge has considerable relevance for identifying effective income transfer policies to help reduce global child malnutrition and hunger.","12004298; ","MAJID, MUHAMMAD FARHAN;","BURES, REGINA M","11/23/2019","02/28/2021","Address; Affect; Age; Anthropometry; Attention; Behavior; behavioral response; Biological; Birth; caregiving; Characteristics; Child; Child Development; Child Health; Child Malnutrition; Child Nutrition; Chronic; Chronic Disease; Cognitive; cohort; commune; cost; Country; critical period; Data; Development; Disease; early childhood; Economic Conditions; Economics; Education; Effectiveness; Elderly; Employment; Ensure; experience; Family; Family Life Surveys; Fire - disasters; Growth; Health; Health Services; Height; Household; Human; Hunger; improved; Income; Indonesia; Institution; Intervention; Investments; Knowledge; Laws; Life Cycle Stages; Light; Location; Longevity; longitudinal dataset; low and middle-income countries; Methods; Modeling; Mothers; Nutritional status; Occupations; parental influence; Parents; Pathway interactions; Policies; Preschool Child; Production; productivity loss; Province; public health relevance; Regulation; Research Priority; Risk; Role; sex; Shapes; Siblings; social; social factors; Social Policies; Socioeconomic Status; statistics; Time; Unemployment; United States National Institutes of Health; Urbanization; Variant; Wages; wasting; Weight; ","Household income at birth and preschool child health","097425","CHHD","Biobehavioral and Behavioral Sciences Subcommittee ","","","03","50000","25500","75500",""
"9910467","R25","NS","5","N","03/27/2020","03/01/2020","02/28/2021","853","R25NS099170","SCHOOLS OF MEDICINE","RFA-NS-16-017","5R25NS099170-04","NINDS:264890\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","DAVIS","UNITED STATES","NEUROLOGY","03","047120084","US","577503","UNIVERSITY OF CALIFORNIA AT DAVIS","CA","956186153","This project will train researchers to discover and develop new treatments for disorders of the brain and nervous system so as to reduce disability and lead to improved quality of life.","2068919 (contact); 6065429; 10442611; ","ROGAWSKI, MICHAEL A. (contact); SCHEIDT, KARL A; SLUSHER, BARBARA STAUCH;","CYWIN, CHARLES L","05/15/2017","02/28/2022","Academia; Address; ADME Study; animal efficacy; apprenticeship; Area; base; Biologic Development; Biological Assay; Biological Markers; Biological Response Modifier Therapy; Brain; Brain Diseases; Cell Therapy; Critiques; design; Development; Development Plans; disability; drug development; drug discovery; Educational Curriculum; efficacy testing; Elements; experience; Faculty; Formulation; Funding; Future; Gene Proteins; Goals; Government; Grant; improved; Individual; Industry; instructor; Intellectual Property; interest; Knowledge; Lead; Learning; lecturer; lectures; Logistics; Medicine; member; Mentors; Mentorship; Monitor; nervous system disorder; Participant; Pharmaceutical Chemistry; Postdoctoral Fellow; Process; Quality of life; recruit; Research; Research Personnel; Resources; responsible research conduct; safety testing; Scientist; Series; skills; small molecule; social media; Specialist; Structure; Students; success; teacher; Teacher Professional Development; Time; Training; Training Programs; United States National Institutes of Health; Vision; Work; ","TRAINING IN NEUROTHERAPUETICS AND DEVELOPMENT FOR ACADEMIC SCIENTISTS","099170","ZNS1","Special Emphasis Panel ","","","04","248381","16509","264890",""
"9922373","R01","HL","5","N","03/26/2020","03/01/2020","02/28/2021","837","R01HL139671","SCHOOLS OF MEDICINE","PA-18-484","5R01HL139671-02","NHLBI:1424662\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NEW YORK","UNITED STATES","INTERNAL MEDICINE/MEDICINE","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) disproportionately afflicts older Black and Hispanic Americans for which there are no effective medical therapies. Cardiac amyloidosis is a cause of heart failure that we hypothesize is misdiagnosed in 10-15% of elderly patients, potentially comprising up to 500,000 people in the United States. In this application, we propose to recruit a cohort of elderly Black and Hispanic patients with heart failure to define the number of patients who have cardiac amyloidosis by utilizing highly sensitive heart imaging and blood tests that we have developed, and to explore differences in genetics and sex as they relate to heart failure disease progression in cardiac amyloidosis.","6096543 (contact); 8082584; ","MAURER, MATHEW S (contact); RUBERG, FREDERICK LIEF;","DESVIGNE-NICKENS, PATRICE","05/01/2019","02/29/2024","Address; African; African American; African Caribbean; Age; age related; aggregation factor; All-Trans-Retinol; Alleles; Amyloid; Amyloidosis; Autopsy; base; Binding; Biological Assay; Biological Markers; Biopsy; Blood; Blood Tests; Cardiac; Caribbean Hispanic; Carrier Proteins; carrier status; Caucasians; Cessation of life; Clinic; Clinical; clinical phenotype; clinical practice; Clinical Trials; cohort; Communities; Data; Deposition; Diagnosis; diagnostic accuracy; Diagnostic tests; Diphosphates; Disease; Disease Progression; Dissociation; Early Diagnosis; Early treatment; effective therapy; EFRAC; Elderly; Failure; Gene Frequency; Genes; Genetic; Genotype; genotyped patients; genotypic sex; Heart failure; heart imaging; Hispanic Americans; Hispanics; Human; Image; improved outcome; Individual; insight; Institution; Isoleucine; Kinetics; Knowledge; Label; male; Measurement; Measures; Medical; Methodology; Minority; monomer; Multicenter Studies; mutant; Mutate; Mutation; mutation carrier; Myocardial; novel marker; nuclear imaging; older patient; Pathogenesis; patient population; Patients; Phenotype; Point Mutation; point-of-care diagnostics; Population; Positioning Attribute; Prealbumin; preservation; Prevalence; prevent; prospective; Prospective cohort study; Proteins; RBP4 gene; recruit; Renal clearance function; Reporting; Reproducibility; Research; Risk; screening; Serum; Sex Distribution; Techniques; Testing; Thyroid Hormones; tool; United States; uptake; Urine; Valine; Variant; ","SCAN-MP (Screening for Cardiac Amyloidosiswith Nuclear imaging in Minority Populations)","139671","CHSB","Cancer, Heart, and Sleep Epidemiology B Study Section ","","","02","1160065","264597","1424662",""
"9924028","U24","MH","3","N","03/24/2020","03/06/2020","02/28/2021","242","U24MH100929","SCHOOLS OF MEDICINE","PA-18-591","3U24MH100929-08S1","NIDA:257607\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","LOS ANGELES","UNITED STATES","NEUROLOGY","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","Project Narrative In order to cure CNS HIV infection and to elucidate the mechanisms of HIV neuropathogenesis under ART, investigators require a reliable source of annotated human tissues, fluids, and data. The National Neurological AIDS Bank (NNAB) has supplied these resources for 2 decades and will continue to do so in the future.","3108724; ","SINGER, ELYSE J;","JOSEPH, JEYMOHAN","05/10/2013","02/28/2023","Acquired Immunodeficiency Syndrome; Address; Adverse effects; Age; Aging; AIDS/HIV problem; Aliquot; Anti-Retroviral Agents; antiretroviral therapy; Autopsy; biobank; Biological; Blood specimen; Central Nervous System Diseases; Central Nervous System Infections; Cerebrospinal Fluid; clinical practice; clinical research site; cohort; Collaborations; Communities; Data; Data Collection; Data Coordinating Center; data sharing; Databases; Diabetes Mellitus; Enrollment; Equipment and supply inventories; Formalin; Freezing; Future; Geography; Goals; Health; high risk; HIV; HIV Infections; HIV Seronegativity; HIV-1; Human; human tissue; Hyperlipidemia; Immune; improved; Individual; Inflammation; Inflammatory Response; interest; Knowledge; Laboratories; Life; Liquid substance; Long-Term Effects; Longevity; Medical; member; Mental disorders; Methodology; mortality risk; National NeuroAids Tissue Consortium; nervous system disorder; Nervous system structure; Neuraxis; neuroAIDS; Neurocognitive Deficit; Neurologic; Neuropathogenesis; Neuropsychology; neurotoxic; Paraffin Embedding; Participant; Pathogenicity; Patients; peer; Penetration; Peripheral; Peripheral Nervous System; Peripheral Nervous System Diseases; Persons; Population; Procedures; programs; Protocols documentation; Provider; Publications; quality assurance; recruit; Research; Research Personnel; research study; Resources; restoration; sample collection; Sampling; Site; Slide; Source; Specimen; Standardization; Time; Tissue Donors; Tissue Embedding; Tissue Harvesting; Tissues; United States National Institutes of Health; Vascular Diseases; Viral; Viral reservoir; Work; ","NATIONAL NEUROLOGICAL AIDS BANK","100929","ZMH1","Special Emphasis Panel ","","S1","08","165133","92474","257607",""
"9986021","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007590","","RFA-MD-18-012","5U54MD007590-33","NIMHD:542454\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","ATLANTA","UNITED STATES","","05","065325177","US","2189101","CLARK ATLANTA UNIVERSITY","GA","303144358","Project Narrative ? Administrative Core The Administrative Core will provide the overall management of the RCMI U54 program and serve as an intermediary between all components of the program, external constituents, and NIMHD.","1878925; ","KHAN, SHAFIQ A;","","","","Accounting; Accounts Payable; anticancer research; Area; Award; base; Budgets; Cancer Biology; career development; Charge; Communication; Communities; Consultations; Contracts; Core Facility; design; Development; dissemination research; Educational workshop; Ensure; Evaluation; experience; Fostering; Goals; Grant; health disparity; Human Resources; insight; Knowledge; Leadership; Malignant neoplasm of prostate; Malignant Neoplasms; meetings; member; Mentors; minority communities; Mission; Molecular Biology; Monitor; Occupational activity of managing finances; Office of Administrative Management; Participant; Periodicity; Pilot Projects; Postdoctoral Fellow; Preparation; Principal Investigator; Productivity; professional atmosphere; Program Evaluation; programs; Progress Reports; recruit; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientist; Series; Services; Source; symposium; Teacher Professional Development; Time; training opportunity; Translating; Universities; Work; Writing; ","Administrative Core","007590","ZMD1","Special Emphasis Panel ","8338","","33","352355","190272","","542454"
"9987731","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","307","U54MD007582","SCHOOLS OF PHARMACY","RFA-MD-18-012","5U54MD007582-35","NIMHD:3021549\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","TALLAHASSEE","UNITED STATES","NONE","05","623751831","US","513802","FLORIDA AGRICULTURAL AND MECHANICAL UNIV","FL","323073105","Public Health Impact: Florida A&M University is proposing to establish the RCMI Center in collaboration and partnerships with community- based organizations to address minority health and health disparities research. The center will enhance FAMU's research capacity, increase the number of minority research investigators, promote minority health, and aid in the reduction of health disparities.","6223124; ","SOLIMAN, KARAM F.A.;","TABOR, DERRICK C","08/01/1997","02/29/2024","Address; African American; anticancer research; Area; Awareness; base; Behavioral; Behavioral Research; Biomedical Research; California; career; Clinic; Collaborations; colorectal cancer screening; Communities; Competence; Comprehensive Cancer Center; Data; Detection; Development; Doctor of Philosophy; Drug Delivery Systems; Education; Effectiveness; Ensure; Environment; Evaluation; Extramural Activities; Faculty; Florida; Funding; Goals; Grant; health disparity; health equity; Health Promotion; improved; innovation; innovative technologies; Institution; Interdisciplinary Study; Intervention; Investigator-Initiated Research; Knowledge; malignant breast neoplasm; Malignant neoplasm of lung; Mentors; Minority; minority health; Mission; novel strategies; novel therapeutics; Pharmacologic Substance; Pilot Projects; Population; programs; Public Health; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Resources; Science; Scientific Inquiry; screening; Screening for cancer; skills; success; United States National Institutes of Health; Universities; Vision; ","FAMU Center for Health Disparities Research","007582","ZMD1","Special Emphasis Panel ","","","35","2044789","976760","3021549",""
"9987742","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007582","","RFA-MD-18-012","5U54MD007582-35","NIMHD:303569\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","TALLAHASSEE","UNITED STATES","","05","623751831","US","513802","FLORIDA AGRICULTURAL AND MECHANICAL UNIV","FL","323073105","","6871503; ","LAMANGO, NAZARIUS SAAH;","","","","3-Dimensional; Address; Adopted; Affect; African American; Amides; analog; angiogenesis; Angiogenesis Inhibition; Animals; anti-cancer; Antineoplastic Agents; Apoptosis; base; Biological Assay; blood vessel development; Breast Cancer Cell; Breast Cancer therapy; cancer cell; Cancer Cell Growth; cancer therapy; cell motility; Cell Proliferation; Cells; Chick Embryo; Clinical; Cytoskeletal Modeling; design; Development; Diagnosis; disparity reduction; drug candidate; drug development; Drug Targeting; effective therapy; Effectiveness; EGF gene; egg; Embryo; Epidermal Growth Factor; Epidermal Growth Factor Receptor; ERBB2 gene; Estrogens; experimental study; F-Actin; Filopodia; Florida; Genetic; genetic regulatory protein; Goals; Growth; GTP-Binding Proteins; Guanosine Triphosphate Phosphohydrolases; health disparity; Human; Hyperactive behavior; hyperactive Ras; improved; in vivo; Incidence; inhibitor/antagonist; Latina; Literature; loss of function mutation; malignant breast neoplasm; Malignant Neoplasms; MAPK3 gene; matrigel; Mediating; Mediator of activation protein; Minority; Mission; Modification; Molecular Chaperones; Monomeric GTP-Binding Proteins; mortality; Mus; Mutation; new therapeutic target; novel; novel drug class; novel strategies; novel therapeutics; Organoids; Outcome; overexpression; Pathway interactions; Patients; Personal Satisfaction; Pharmacotherapy; Post-Translational Protein Processing; Progesterone; Protein Family; protein function; protein metabolism; Proteins; RAS Superfamily Proteins; receptor; Research; Research Project Grants; rho; Role; Signal Pathway; Signal Transduction; Structure; Survival Rate; targeted agent; targeted treatment; Therapeutic; Treatment Efficacy; triple-negative invasive breast carcinoma; Tube; tumor; tumor growth; tumor progression; Tumor Volume; tumor xenograft; Universities; Vascular Endothelial Growth Factors; Woman; Xenograft procedure; Zebrafish; ","Research Project 1","007582","ZMD1","Special Emphasis Panel ","8129","","35","205114","98455","","303569"
"9987746","U54","MD","5","N","03/27/2020","03/01/2020","02/28/2021","","U54MD007582","","RFA-MD-18-012","5U54MD007582-35","NIMHD:270996\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","TALLAHASSEE","UNITED STATES","","05","623751831","US","513802","FLORIDA AGRICULTURAL AND MECHANICAL UNIV","FL","323073105","","8861397; ","LUQUE, JOHN S;","","","","Address; Adherence; African American; Age; Area; arm; base; Behavior Therapy; Cancer Death Rates; cancer health disparity; Cellular Phone; Cessation of life; Client; Clinic; Colonoscopy; Colorectal Cancer; colorectal cancer risk; colorectal cancer screening; Communication; Communities; Community Health; community setting; comparative effectiveness; Control Groups; cost effective; cost effectiveness; Cost Effectiveness Analysis; cost-effectiveness ratio; Counseling; County; Education; education research; education resources; Educational Intervention; Educational Materials; Effect Modifiers (Epidemiology); Effectiveness; Effectiveness of Interventions; effectiveness trial; epidemiologic data; Ethnic group; evidence base; experience; Family Cancer History; Florida; follow-up; Fright; Future; Goals; group intervention; health belief; health disparity; Health education; health literacy; improved; Incidence; incremental cost-effectiveness; innovation; Intention; Intervention; intervention effect; Knowledge; Literature; Logistics; Malignant Neoplasms; Measures; Mediating; Mediator of activation protein; member; men; Modality; mortality; multi-component intervention; National Cancer Institute; Not Hispanic or Latino; Outcome; Outcome Study; outreach; Participant; Patient Education; Persons; Population; post intervention; Predisposition; preference; prevent; preventable death; primary outcome; programs; racial and ethnic; Randomized; Randomized Controlled Trials; randomized trial; Recording of previous events; recruit; Research; Research Design; Research Personnel; Research Project Grants; Resources; Rural Community; Sampling; Science; screening; Screening for cancer; secondary outcome; Self Efficacy; sex; Site; System; Telephone; Test Result; Testing; Text; Text Messaging; therapy design; tv watching; Voice; ","Research Project 3","007582","ZMD1","Special Emphasis Panel ","8131","","35","183106","87890","","270996"
"9998698","R01","AI","1","N","03/24/2020","03/25/2020","02/28/2021","855","R01AI152533","SCHOOLS OF MEDICINE","PA-19-056","1R01AI152533-01","NIAID:741668\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LA JOLLA","UNITED STATES","PEDIATRICS","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","LAY ABSTRACT Malaria continues to exert a heavy toll on global heath. However, if better preventative drugs were available, it is possible that malaria might be eliminated. Better protective antimalarials are also needed by the traveling public and the military. Our objective is to create better drugs that prevent malaria and which are easier to use.","1901612; ","WINZELER, ELIZABETH A;","O'NEIL, MICHAEL T","03/25/2020","02/28/2025","Acetyl Coenzyme A; ADME Study; Amino Acyl-tRNA Synthetases; Anemia; animal efficacy; Animal Model; Animals; Antimalarials; asexual; base; Binding Proteins; Biological Assay; Blood; Cell Culture Techniques; Cells; Cerebral Malaria; Cessation of life; Chemoprevention; Chemoprophylaxis; Chemoprotective Agent; Clinical; clinical candidate; Clinical Trials; Cluster Analysis; Culicidae; Data Set; design; Development; Dihydrofolate Reductase; Dihydroorotate dehydrogenase; Disease; Drug Design; drug development; Drug Kinetics; Drug resistance; drug testing; efficacy testing; Erythrocytes; Evolution; Family; genome analysis; Genomics; Goals; Human; In Vitro; Infection; inhibitor/antagonist; Injectable; International; Intramuscular Injections; Investigation; lead optimization; Liver; Luciferases; Malaria; malaria infection; Malaria prevention; Medicine; metabolic profile; Methods; Military Personnel; Mitochondria; mouse model; next generation; novel; Oral; Parasite resistance; Parasites; Patients; Persons; Pharmaceutical Preparations; Phenotype; Phosphotransferases; Plasmodium; Plasmodium falciparum; Plasmodium vivax; Population; predictive modeling; predictive test; prevent; Prodrugs; prophylactic; Prophylactic treatment; Proteins; Proteomics; Public Health; Research Personnel; scaffold; screening; Series; Severities; small molecule; Structure; symptom treatment; Testing; Therapeutic antibodies; therapy development; tool; Toxic effect; Travel; Vaccines; whole genome; Work; ","Discovery of long-acting, chemoprotective antimalarial compounds","152533","ZRG1","Special Emphasis Panel ","","","01","583830","157838","741668",""