"APPLICATION_ID","ACTIVITY","ADMINISTERING_IC","APPLICATION_TYPE","ARRA_FUNDED","AWARD_NOTICE_DATE","BUDGET_START","BUDGET_END","CFDA_CODE","CORE_PROJECT_NUM","ED_INST_TYPE","FOA_NUMBER","FULL_PROJECT_NUM","FUNDING_ICs","FUNDING_MECHANISM","FY","IC_NAME","NIH_SPENDING_CATS","ORG_CITY","ORG_COUNTRY","ORG_DEPT","ORG_DISTRICT","ORG_DUNS","ORG_FIPS","ORG_IPF_CODE","ORG_NAME","ORG_STATE","ORG_ZIPCODE","PHR","PI_IDS","PI_NAMEs","PROGRAM_OFFICER_NAME","PROJECT_START","PROJECT_END","PROJECT_TERMS","PROJECT_TITLE","SERIAL_NUMBER","STUDY_SECTION","STUDY_SECTION_NAME","SUBPROJECT_ID","SUFFIX","SUPPORT_YEAR","DIRECT_COST_AMT","INDIRECT_COST_AMT","TOTAL_COST","TOTAL_COST_SUB_PROJECT"
"9991993","F31","HD","1","N","04/22/2020","05/01/2020","04/30/2021","865","F31HD100098","SCHOOLS OF MEDICINE","PA-19-195","1F31HD100098-01A1","NICHD:31446\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","SAINT LOUIS","UNITED STATES","NEUROSCIENCES","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","Human genetic studies have linked intellectual disability to disruption of genes encoding epigenetic factors, but little is known about how a variety of different disease mutations disrupt protein function to lead to disease. DNA methyltransferase 3a (DNMT3A) functions to add methyl groups to cytosines in DNA, and mutations in DNMT3A are associated with a neurodevelopmental disorder with intellectual disability known as Tatton-Brown-Rahman Syndrome (TBRS). Though DNA methylation is classically considered to only occur in mammalian cells in the CpG context, neurons have high levels of a recently-discovered form of methylation in non-CpG contexts established by DNMT3A. This non-CpG methylation, primarily occurring at CA dinucleotides (mCA), is critical to proper neuronal development, as it is necessary for establishment of neuronal cell-type-specific transcription. Though mCA plays an important role regulating neuronal gene expression, little is known about how loss of DNMT3A and mCA relate to neurodevelopmental disease. Additionally, it is unknown how mutations within the three conserved protein domains of DNMT3A each mechanistically lead to loss of mCA. In this proposal, I will determine how disease mutations in the chromatin targeting domains of DNMT3A impact protein function and demonstrate how DNMT3A disruption alters neuronal transcription. In Aim 1, I model disease mutations identified in TBRS studies and analyze how disease mutations within different protein domains differentially affect targeting to the genome and methyltransferase activity to alter mCA build-up. This will define the mechanisms leading to disease and provide insight into the functional domains of DNMT3A. In Aim 2, I will explore how loss of DNMT3A differentially affects specific neuronal cell-types, dissecting out how the epigenome and transcriptome are changed during maturation of Parvalbumin positive interneurons and Somatostatin positive interneurons. This analysis will begin to uncover how disruption of DNMT3A affects specific cell types and will result in target genes such as ion channels or receptors to further study functional cellular outcomes. Together, these analyses will elucidate the function of DNMT3A and mCA in neurons and mechanistically link them to neurodevelopmental disease.","15212108; ","CHRISTIAN, DIANA ;","PARISI, MELISSA","05/01/2020","04/30/2022","Ablation; Adult; Affect; autism spectrum disorder; base; Behavioral; Binding; Biology; Brain; Cell Culture System; Cell physiology; cell type; Cerebral cortex; Cessation of life; Chromatin; Cytosine; Deposition; Development; Dinucleoside Phosphates; Disease; Disease model; DNA Binding; DNA Methylation; DNA Modification Methylases; DNA Sequence Alteration; DNA-Binding Proteins; Enzymes; Epigenetic Process; epigenome; Etiology; Explosion; Functional disorder; Future; Gene Expression; Gene Expression Profile; Genes; Genetic study; Genetic Transcription; Genome; genome wide methylation; Genomic approach; Genomics; Histones; Human; Human Genetics; In Vitro; in vitro Assay; in vivo; insight; Intellectual functioning disability; Interneurons; Ion Channel; Knockout Mice; Lead; Link; link protein; Mammalian Cell; Maps; methyl group; Methylation; Methyltransferase; Modeling; Molecular; Mus; Mutant Strains Mice; Mutation; nervous system disorder; Nervous System Physiology; Nervous system structure; neurodevelopment; Neurodevelopmental Disorder; Neurologic Deficit; neuron development; Neurons; Nuclear; Nucleic Acid Regulatory Sequences; Outcome; Parvalbumins; Pathology; Pattern; Phenotype; Play; Population; Predisposition; protein activation; protein function; Proteins; receptor; Regulation; Research; Role; Seizures; Somatostatin; Structure; Syndrome; System; Tertiary Protein Structure; Testing; transcriptome; transcriptomics; Work; ","Dissecting the mechanism and function of DNMT3A in neural development","100098","ZRG1","Special Emphasis Panel ","","A1","01","31446","","31446",""
"9894569","R21","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R21AI144641","","PA-19-053","1R21AI144641-01A1","NIAID:175000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","080798860","US","10047972","HDT BIO CORPORATION","WA","981023788","PROJECT NARRATIVE Despite the provision of free multidrug therapy by the World Health Organization, leprosy remains a public health problem and disease elimination will likely require a vaccine. We have developed LepVax, a new leprosy vaccine that provides effective pre-exposure and post-exposure protection in animal models and demonstrated safety in a Phase 1 clinical trial. The studies proposed here will characterize immune responses elicited by LepVax, validate assays to ensure data robustness going forward, and develop exploratory assays to maximize output from the next clinical trials in target populations.","8246165; ","DUTHIE, MALCOLM S;","EICHELBERG, KATRIN","05/21/2020","04/30/2022","Address; Animal Model; anti-leprosy vaccine; Antibodies; Antigens; Biological Assay; Biological Markers; Blood specimen; Brazil; candidate marker; Case Study; Charge; Chimeric Proteins; Chronic Disease; Clinical; clinical development; Clinical Trials; Country; cytokine; Data; Dermatologic; Detection; disability; Disease; Dose; Ensure; Enzyme-Linked Immunosorbent Assay; experience; Family Dasypodidae; first-in-human; Flow Cytometry; Funding; Future; Genus Mycobacterium; global health; Goals; Gold; Growth; Human; human study; IgG1; Immune; Immune response; immunogenicity; Immunoglobulin G; Immunophenotyping; Incidence; Individual; Infection; Intercept; Interferon Type II; Intervention; Leprosy; Licensure; London; Lymphocyte Activation; Measures; Methods; Modeling; Mus; mycobacterial; Mycobacterium bovis; Mycobacterium leprae; neglected tropical diseases; nervous system disorder; Nervous system structure; Neurologic; Organism; Output; Patients; Performance; Phase; Phase I Clinical Trials; programs; prophylactic; Prophylactic treatment; Public Health; public health priorities; Regimen; Reporting; research clinical testing; response; Risk; Safety; Sampling; Serum; Serum Proteins; Skin; Specific qualifier value; Specificity; Specimen; Stains; Subunit Vaccines; Target Populations; tool; transmission process; Tuberculosis; Vaccination; vaccine candidate; Vaccine Clinical Trial; vaccine development; vaccine efficacy; vaccine evaluation; Vaccines; validation studies; Whole Blood; Work; World Health Organization; ","Assessing immunogenicity of LepVax: a new leprosy vaccine in clinical development","144641","VMD","Vaccines Against Microbial Diseases Study Section ","","A1","01","125000","50000","175000",""
"9692803","R01","MH","5","N","05/20/2020","05/01/2020","04/30/2021","242","R01MH108442","SCHOOLS OF MEDICINE","PA-14-127","5R01MH108442-05","NIMH:336658\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","DETROIT","UNITED STATES","FAMILY MEDICINE","13","001962224","US","9110501","WAYNE STATE UNIVERSITY","MI","482024050","PUBLIC HEALTH RELEVANCE: Youth living with HIV show significant adherence difficulties resulting in poor health outcomes as well as increased likelihood of transmission of the disease. If successful, the proposed adherence intervention, by targeting adherence issues before they begin, could improve the individual health of these youth, and also affect public health by reduced transmission when viral loads are improved and reduced likelihood of transmitting resistant strains of virus.","2481755; 1948959 (contact); ","NAAR, SYLVIE ; OUTLAW, ANGULIQUE Y (contact);","ALLISON, SUSANNAH","08/01/2015","04/30/2021","Acquired Immunodeficiency Syndrome; active control; Address; Adherence; adherence rate; Adolescent Medicine; Adolescent Medicine Trials Network; Adult; Affect; Age; AIDS/HIV problem; analog; antiretroviral therapy; Area; base; Behavior Therapy; Behavioral; Biological Assay; brief intervention; CD4 Lymphocyte Count; comparative efficacy; Computer software; Computers; Disease Management; disease transmission; Dose; Elements; Event; executive function; Exercise; follow-up; Funding; Hair; Health; HIV; improved; Individual; innovation; Intervention; Knowledge; Life; Measures; Mediator of activation protein; medication compliance; Medicine; Mental Health; Modeling; Motivation; motivational enhancement therapy; motivational intervention; Nature; novel; novel strategies; nutrition; Outcome; overtreatment; Perception; Persons; prevent; Prevention approach; Prevention program; Preventive Intervention; primary outcome; Primary Prevention; Protocols documentation; Public Health; public health relevance; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; recruit; resistant strain; response; Sampling; Self Efficacy; Site; skills; Specimen; standard care; Structure; Substance abuse problem; Symptoms; System; Technology; Testing; theories; transmission process; treatment adherence; treatment effect; trend; United States; United States National Institutes of Health; Update; Viral Load result; Virus; Visual; Youth; ","Motivational Enhancement System for Adherence (MESA) for Youth Starting ART","108442","BSCH","Behavioral and Social Consequences of HIV/AIDS Study Section ","","","05","232376","104282","336658",""
"10055808","R21","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R21AI148774","SCHOOLS OF MEDICINE","PA-19-053","1R21AI148774-01A1","NIAID:237480\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","HERSHEY","UNITED STATES","PATHOLOGY","10","129348186","US","1524204","PENNSYLVANIA STATE UNIV HERSHEY MED CTR","PA","170332360","NARRATIVE Pathogens can form organized multicellular communities known as biofilms. This proposal explores the cues that govern the synthesis of a biofilm component in a bacterial pathogen. !","11286751; ","PONTES, MAURICIO HENRIQUES;","ALEXANDER, WILLIAM A","05/21/2020","04/30/2022","Acute; acute infection; Affect; Anabolism; Bacteria; Behavior; Biological Assay; cell motility; Cell physiology; Cells; Cellulose; Communities; Cues; Defect; Development; diguanylate cyclase; environmental change; enzyme activity; Enzymes; experience; Extracellular Matrix; Fluorescence; Fostering; Genes; genetic analysis; Genetic Epistasis; GMP synthase; Goals; Growth; High-Throughput Nucleotide Sequencing; Infection; Investigation; Life Style; macrophage; Maps; Mediating; Metabolic; Metabolic Control; Metabolism; metabolomics; Microbial Biofilms; Mus; mutant; Mutation; novel; Organism; pathogen; pathogenic bacteria; Pathway interactions; Periodicity; Phagocytes; phosphoric diester hydrolase; Physiological; Physiological Adaptation; Play; Production; Protein Biosynthesis; Proteins; Proxy; Pyruvate Kinase; Reporter; Reporting; Ribosomes; Role; Salmonella; Salmonella typhimurium; Second Messenger Systems; Signal Transduction; Signaling Molecule; Testing; Translational Activation; Virulence; ","Metabolic control of the second messenger cyclic diguanylate: implications to intracellular bacterial pathogens","148774","PCMB","Prokaryotic Cell and Molecular Biology Study Section ","","A1","01","150000","87480","237480",""
"10145109","P30","CA","3","N","05/21/2020","03/04/2020","12/31/2020","397","P30CA015704","","PAR-17-095","3P30CA015704-45S2","NCI:249999\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","SEATTLE","UNITED STATES","","07","078200995","US","861001","FRED HUTCHINSON CANCER RESEARCH CENTER","WA","981094433","PROJECT NARRATIVE: OVERALL There were an estimated 1.7 million new cases of cancer in the United States in 2018, and an estimated 609,000 deaths from the disease. Cancer is the second leading cause of the death in the U.S. The goal of the Fred Hutchinson/University of Washington Cancer Consortium is the elimination of cancer as a cause of suffering and death through more effective prevention, diagnosis, and treatment, deriving from fundamental insights into the biology of the disease.","8549026; ","LYNCH, THOMAS JAMES;","HE, MIN","01/01/1997","12/31/2024","Alaska; anticancer research; Area; base; Biology; Cancer Biology; cancer care; Cancer Center; Cancer Center Support Grant; Cancer Detection; cancer diagnosis; Cancer Etiology; cancer therapy; carcinogenesis; Carcinogenesis Mechanism; Caregivers; Catchment Area; Cause of Death; Cessation of life; Child; Childhood; Clinical; clinical care; clinical practice; Clinical Research; Collaborations; Communities; Comprehensive Cancer Center; Computational Biology; computer studies; County; Development; Diagnosis; Diagnostic; Discipline; Disease; Education and Outreach; Educational process of instructing; Enrollment; Ensure; epigenomics; Exposure to; Faculty; Faculty Recruitment; Fostering; Funding; Genomics; Goals; graduate student; Grant; Health; Health Sciences; Hematopoietic Stem Cell Transplantation; host neoplasm interaction; Idaho; Immunology; Immunotherapeutic agent; improved; Individual; insight; Institution; inter-institutional; interdisciplinary collaboration; interest; Intervention; Investments; Knowledge; Laboratories; Laboratory Research; Leadership; Malignant Neoplasms; Measures; member; Mentors; Mission; Molecular; Montana; mortality; multidisciplinary; next generation; Outcome; outreach; pathogen; Patients; Peer Review; Population Research; Postdoctoral Fellow; Prevention; Prevention strategy; Primary Prevention; profiles in patients; programs; Public Health; Quality of Care; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Risk Factors; Science; Secondary Prevention; Students; synthetic biology; targeted treatment; Therapeutic; therapy development; Training; Training and Education; Training Support; Translating; Translational Research; Translations; Transplantation; treatment center; treatment trial; tumor; tumor metabolism; tumor progression; Underrepresented Groups; United States; Universities; Washington; Work; Wyoming; ","Cancer Center Support Grant","015704","NCI","Subcommittee I - Transistion to Independence ","","S2","45","142045","107954","249999",""
"9937811","T32","EY","5","N","05/20/2020","04/01/2020","03/31/2021","867","T32EY007136","SCHOOLS OF ARTS AND SCIENCES","PA-18-403","5T32EY007136-27","NEI:244157\","TRAINING, INSTITUTIONAL","2020","NATIONAL EYE INSTITUTE","","NEW YORK","UNITED STATES","NEUROSCIENCES","12","041968306","US","5998301","NEW YORK UNIVERSITY","NY","100122300","Project Narrative This project will train researchers in vision research, to provide the next generation of advances that will fuel national and international research progress in the visual sciences. The trainees will enhance our understanding of visual function and enable remediation of disabling diseases of the eye and central visual system.","1965976; ","MOVSHON, J ANTHONY;","AGARWAL, NEERAJ","01/01/1993","03/31/2024","Training; visual neuroscience; ","Training in Visual Neuroscience","007136","ZEY1","Special Emphasis Panel ","","","27","251634","15011","244157",""
"9921440","P30","EY","5","N","05/20/2020","04/01/2020","03/31/2021","","P30EY008098","","PAR-17-322","5P30EY008098-32","NEI:27377\","RESEARCH CENTERS","2020","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","","9403772; ","GROSS, JEFFREY ;","","","","Collaborations; Communication; Core Grant; Effectiveness; Ensure; Faculty; Funding; Future; Goals; Research Personnel; Resources; Services; Strategic Planning; Vision research; ","Administrative Core","008098","ZEY1","Special Emphasis Panel ","5954","","32","17493","9884","","27377"
"9985105","R01","DA","5","N","05/19/2020","05/01/2020","04/30/2021","279","R01DA036612","SCHOOLS OF MEDICINE","PA-18-060","5R01DA036612-07","NIDA:423980\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","LA JOLLA","UNITED STATES","NEUROSCIENCES","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","PROJECT NARRATIVE Achieving a better understanding of the neural circuitry that control motivated behavior is critical to developing new strategies to treat and prevent drug addicition and other compulsive disorders. Dopamine neurons in the VTA have been widely implicated as a common substrate of drugs of abuse, but other VTA neuron types also contribute and may represent new targets for future intervention. This continuing research program will evaluate the contribution of novel populations of VTA neurons that release and co-release glutamate to behavioral reinforcement and other processes that underlie addictions.","8861110; ","HNASKO, THOMAS ;","SORENSEN, ROGER","04/01/2014","04/30/2024","addiction; Adult; Amino Acid Neurotransmitters; Anabolism; Anatomy; Animals; Basal Ganglia; base; Behavior; Behavior Control; Behavioral; Biological Assay; Cell Nucleus; cell type; Cells; Clustered Regularly Interspaced Short Palindromic Repeats; Complex; CRISPR/Cas technology; Development; Disease; Distal; Dopamine; dopaminergic neuron; Drug Addiction; drug of abuse; Drug Targeting; Electron Microscopy; Electrophysiology (science); frontal lobe; Future; gamma-Aminobutyric Acid; Genetic; genetic approach; Globus Pallidus; Glutamates; Goals; Habenula; Heterogeneity; Image; Interneurons; Intervention; Label; Lateral; Learned Helplessness; light microscopy; Limbic System; Link; Maps; Mediating; Membrane Potentials; motivated behavior; Mus; Negative Reinforcements; neural circuit; Neuromodulator; Neurons; neuropsychiatric disorder; novel; optogenetics; Pathway interactions; Pharmaceutical Preparations; Population; Positioning Attribute; Positive Reinforcements; postsynaptic neurons; prevent; Process; programs; Psychological reinforcement; Recycling; Research; Rewards; Role; Selective Serotonin Reuptake Inhibitor; Shapes; Signal Transduction; Site; Synapses; targeted treatment; Testing; Ventral Striatum; Ventral Tegmental Area; ","Role of novel VTA neurons in addiction-related behaviors","036612","NMB","Neurobiology of Motivated Behavior Study Section ","","","07","271677","152303","423980",""
"9921436","P30","EY","5","N","05/20/2020","04/01/2020","03/31/2021","","P30EY008098","","PAR-17-322","5P30EY008098-32","NEI:161381\","RESEARCH CENTERS","2020","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","","1863527; ","HENDRICKS, ROBERT L;","","","","base; Biological Assay; Cell Separation; Cells; Cellular Morphology; Computer software; Consult; Core Grant; Data Analyses; design; Development; experience; Faculty; Flow Cytometry; Fluorescent Antibody Technique; Fluorescent Dyes; Goals; Instruction; Label; Laboratory Personnel; Lasers; Learning; Measurement; Methodology; operation; Phenotype; Population; Principal Investigator; programs; Research; Research Personnel; Research Project Grants; Sampling; Scientist; Services; Signal Transduction; single cell analysis; Sorting - Cell Movement; Specific qualifier value; Speed; Suspensions; Techniques; Technology; theories; Training; Vision; Vision research; ","Flow Cytometry Core","008098","ZEY1","Special Emphasis Panel ","5952","","32","103119","58262","","161381"
"9925294","R01","HL","5","N","05/18/2020","05/01/2020","04/30/2021","838","R01HL135156","","PA-13-302","5R01HL135156-04","NCMHD:160000\NHLBI:605609\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","DENVER","UNITED STATES","","01","076443019","US","5720901","NATIONAL JEWISH HEALTH","CO","802062761","PROJECT NARRATIVE Although all people with asthma exhibit some degree of airway obstruction and respiratory symptoms, the clinical severity of their disease and response to common asthma medications varies greatly. We will use genetic and genomic analyses of nasal airway epithelial brushings from children with asthma to identify the pathobiological mechanisms (endotypes) that underlie severe asthma disease and poor response to albuterol. Results from this study will inform clinical practice and therapeutic decisions.","6266245; 10398827 (contact); ","BURCHARD, ESTEBAN GONZALEZ; SEIBOLD, MAX  (contact);","NOEL, PATRICIA","05/01/2017","04/30/2022","Adrenal Cortex Hormones; Affect; African American; airway epithelium; airway inflammation; airway obstruction; Albuterol; analytical method; Asthma; asthma exacerbation; asthmatic; Biological Markers; Blood; Bronchoscopy; Cell Culture Techniques; Cells; Child; Childhood Asthma; Chromosome Mapping; Clinical; clinical practice; Collaborations; Communities; Complex; Computer Analysis; cytokine; Data; Death Rate; design; differential expression; Disease; disease phenotype; DNA; Environment; Epithelial; Epithelial Cells; Epithelium; ethnic difference; ethnic diversity; Exhibits; experience; Expression Profiling; Functional disorder; Gene Expression; Gene Expression Profiling; Genetic; Genetic Determinism; Genetic Markers; Genetic Screening; Genetic Transcription; genome sequencing; genome wide association study; Genomics; Goals; Health Policy; Heterogeneity; high risk; Human; In Vitro; Infection; Inhalation; Interleukin-13; Laboratories; Latino; Lead; Measures; Medical; Methods; minimally invasive; minority children; Modeling; Molecular; Morbidity - disease rate; mortality; Nasal Epithelium; Nose; novel; Pathogenesis; Pathology; Patients; peripheral blood; personalized medicine; Pharmaceutical Preparations; Pharmacogenetics; Population; Public Health; Publications; Puerto Rican; racial and ethnic; Recurrence; Research; Resources; Respiratory physiology; Respiratory Signs and Symptoms; response; Rhinovirus; Risk; RNA; Sampling; Severities; Subgroup; success; synergism; targeted treatment; Testing; Therapeutic; trait; transcriptome; transcriptome sequencing; transcriptomics; whole genome; ","Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority Children","135156","IRAP","Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section ","","","04","600374","165235","765609",""
"9916744","U10","CA","5","N","05/18/2020","03/01/2020","02/28/2021","","U10CA180868","","RFA-CA-17-056","5U10CA180868-07","NCI:6252584\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","PHILADELPHIA","UNITED STATES","","03","078695317","US","10033231","NRG ONCOLOGY FOUNDATION, INC.","PA","191032800","","1873940; ","WOLMARK, NORMAN ;","","","","Adolescent and Young Adult; African; Alaska Native; American; base; Clinical Research; Communication; Country; Credentialing; data quality; Discipline of Nursing; Disease; Enrollment; General Population; Grant; Guidelines; health disparity; Hispanics; Image; improved; innovation; Latino; Malignant Neoplasms; member; Mission; Monitor; Monitoring Clinical Trials; National Clinical Trials Network; Native Americans; Native Hawaiian; oncology; oncology trial; operation; Pacific Island Americans; Patients; Performance; Process; programs; Protocols documentation; Puerto Rico; quality assurance; Radiation Oncology; Radiation therapy; rare cancer; Review Committee; Science; Site; Time; Translational Research; Underrepresented Populations; Update; Washington; ","NRG Oncology Network Group Operations Center","180868","ZCA1","Special Emphasis Panel ","7985","","07","6717144","134284","","6252584"
"9944688","R01","MH","5","N","05/22/2020","05/01/2020","04/30/2021","242","R01MH113761","","PA-16-388","5R01MH113761-04","NIMH:442500\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BOSTON","UNITED STATES","","07","076593722","US","1504801","BOSTON CHILDREN'S HOSPITAL","MA","021155724","NARRATIVE  The overarching goal of the proposed research is to improve our understanding of the neurobiological basis of autism spectrum disorders (ASDs). In this project we will analyze sequencing data collected from tens of thousands of individuals with and without ASD, examine the rate at which gene knockouts (mutations that disrupt both functional copies of a gene) occur, and generate a catalog of gene knockouts that are seen in individuals with autism. Gene knockouts, while rare, can reveal critical biological pathways that teach us about the basis of disease, and possibly lead to treatments.","10431218; ","YU, TIMOTHY WEI-WEN;","GITIK, MIRI","07/21/2017","04/30/2022","Affect; Attention; autism spectrum disorder; autistic; Behavior; biobank; Biological; Biological Process; Biology; Brain; Candidate Disease Gene; Case-Control Studies; Catalogs; Categories; Cell Line; chromatin remodeling; Clustered Regularly Interspaced Short Palindromic Repeats; cohort; Collection; Complex; Data; Data Set; de novo mutation; Defect; Development; Disease; disorder risk; exome; experimental study; Functional disorder; Future; Gender; Gene Frequency; General Population; Generations; Genes; genetic architecture; Genetic Screening; Genetic study; Genome; Goals; human population genetics; human tissue; improved; Individual; insight; interest; Investigation; Knock-out; knockout gene; Language Delays; Large-Scale Sequencing; Lead; Link; male; Modeling; Molecular; Mutation; National Institute of Mental Health; Neurobiology; Neurons; novel; Nuclear Hormone Receptors; Pathogenesis; Pathway interactions; Pattern; Phase; Phenotype; Population; Publishing; rare variant; Research; Risk; risk variant; Sample Size; Sampling; Social Behavior; Social Interaction; Stereotyping; Steroids; Structure; Synapses; Testing; Transcription Coactivator; transcription factor; Validation; Variant; whole genome; Work; ","Complete gene knockouts in autism: identification and functional characterization","113761","GHD","Genetics of Health and Disease Study Section ","","","04","250000","192500","442500",""
"9922306","P20","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P20GM103440","","PAR-14-233","5P20GM103440-18","NIGMS:1570650\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","Outreach / Diversity / Pipeline Program - Project Narrative The Outreach / Diversity / Pipeline program will train a diverse workforce to be the next generation of biomedical and bioinformatics specialists in Nevada. Undergraduate students from underserved communities will experience intensive summer workshops, hands-on training, mentoring and engagement in authentic research to increase their success along the pathway to careers in biomedical and bioinformatics research.","11346171; ","ELLSWORTH, JULIE ;","","","","Address; Awareness; base; Bioinformatics; Biomedical Research; bridge program; career; cell growth; college; Communities; community college; curriculum development; Differentiation and Growth; Diverse Workforce; Economically Deprived Population; Education; education pathway; Educational Curriculum; Educational process of instructing; Educational workshop; Enrollment; experience; Future; Generations; Graduation Rates; Industry; Infrastructure; Institution; Internships; Link; Mentors; Minority; Mission; Nevada; next generation; Occupations; outreach; Pathway interactions; peer; programs; Readiness; Research; Research Personnel; Science; southern nevada; Specialist; Students; success; symposium; Teacher Professional Development; Training; undergraduate research; undergraduate student; Underrepresented Students; Underserved Population; Underserved Students; Universities; workforce needs; ","Outreach/Diversity/Pipeline Project","103440","ZGM1","Special Emphasis Panel ","7786","","18","1543426","27224","","1570650"
"10069080","F31","DK","1","N","05/12/2020","05/12/2020","05/11/2021","847","F31DK126457","SCHOOLS OF MEDICINE","PA-19-196","1F31DK126457-01","NIDDK:45520\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","Los Angeles","UNITED STATES","PHYSIOLOGY","37","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PROJECT NARRATIVE  Main risk factors for chronic kidney disease are high blood pressure and type 2 diabetes, which account for about 75% of all chronic kidney disease cases. Premenopausal females are protected against disease (hypertension, cardiovascular and diabetic kidney disease) and mechanisms contributing to this ?female advantage? are understudied. This proposal aims to define key sexual dimorphic regulatory mechanisms in kidney disease that can inform sex-tailored treatments to reduce progression of chronic kidney disease.","15501699; ","MCFARLIN, BRANDON EUGENE;","RIVERS, ROBERT C","05/12/2020","05/11/2022","Accounting; Acute; Adult; Affect; Age; Apical; base; Biological Markers; Blood; Blood Pressure; blood pressure reduction; blood pressure regulation; Cardiovascular Diseases; cardiovascular disorder risk; Cardiovascular system; cellular microvillus; Chronic; Chronic Kidney Failure; comorbidity; Diabetes Mellitus; diabetic; Diabetic Nephropathy; diabetic rat; Disease; Disease Progression; Diuresis; Electrolytes; Excretory function; Exhibits; exosome; experimental study; Female; Glucose; Goals; Homeostasis; human disease; Hypertension; Immunoblot Analysis; Immunohistochemistry; improved; in vivo; Incidence; Individual; individualized medicine; Injury; Injury to Kidney; insight; Kidney; Kidney Diseases; Learning; Limb structure; Liquid substance; Location; male; Mediating; Mediator of activation protein; Metabolic; Modeling; Modification; Morphology; Natriuresis; Nephrons; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Operative Surgical Procedures; Pathologic; Patients; Phenotype; Phosphotransferases; Physiological; Physiology; Play; Population; Postmenopause; Premenopause; pressure; Rattus; real-time images; Regulation; Research; response; Risk Factors; Role; Saline; sex; sexual dimorphism; Signal Transduction; Sodium Chloride; Sprague-Dawley Rats; Therapeutic; Thick; Thinness; Time; Tubular formation; two photon microscopy; urinary; vasoconstriction; wasting; Woman; ","Pressure Natriuresis and Renal Na+ Transporter Regulation in Males and Females: Impact of Diabetes with Hypertension","126457","ZDK1","Special Emphasis Panel ","","","01","45520","","45520",""
"10038935","R21","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R21AI153817","SCHOOLS OF MEDICINE","PA-18-872","1R21AI153817-01","NIAID:226845\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","IOWA CITY","UNITED STATES","PEDIATRICS","02","062761671","US","3972901","UNIVERSITY OF IOWA","IA","522421320","The live attenuated varicella vaccine was approved by the FDA in 1995 for universal administration to all children in the United States. We have identified a problem with the live attenuated vaccine that may lead to more severe cases of reactivation and herpes zoster.","1969867; ","GROSE, CHARLES F.;","BEISEL, CHRISTOPHER E","05/21/2020","04/30/2022","Acyclovir; Admission activity; Adverse event; afferent nerve; Alleles; Applications Grants; Arginine; Arvin; Asians; Asthma; Attenuated; Attenuated Live Virus Vaccine; attenuation; Autoimmune Diseases; base; Cessation of life; Chickenpox; Chickenpox Vaccine; Child; Country; Data; dermatome; Disease; European; Exanthema; FDA approved; Genes; Genetic Polymorphism; Genome; Goals; Grant; Hearing; Herpes zoster disease; Immunize; Immunocompetent; improved; Infection; Injections; Iowa; Journals; Lead; Left; mouse model; Mutate; Mutation; North America; Nucleotides; Open Reading Frames; Patients; Pediatric Neurology; Physicians; Proteins; Reporting; Research; Research Personnel; Risk Factors; Role; SCID Mice; Scientist; Secondary to; side effect; Site; Skin; Spinal Ganglia; Structure; Terminator Codon; Thigh structure; Transverse Myelitis; Travel; United States; Vaccination; Vaccine Design; vaccine safety; Vaccines; Variant; varicella-zoster virus glycoprotein gp1; varicella-zoster virus immediate early protein 62; Viral; Viremia; virtual; Virulence; Virulent; Virus; Virus Diseases; VZV vaccine; whole genome; Work; ","Wild-type allele found in varicella vaccine virus during severe herpes zoster","153817","VIRB","Virology - B Study Section ","","","01","150000","76845","226845",""
"9938679","R25","MH","5","N","05/18/2020","04/01/2020","03/31/2021","242","R25MH094612","","PAR-14-306","5R25MH094612-09","NIMH:195550\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Project Narrative In 2007, the Massachusetts General Hospital (MGH) and McLean Hospital piloted an integrated Research Concentration within the MGH/McLean Adult Psychiatry Residency Training Program to address the critical shortage of physician-scientists engaged in mental health research careers. This now established program has been highly successful through its first federally funded period. This competitive renewal application will provide support and infrastructure to continue, improve, and expand this well-integrated research education program that serves to attract and train residents to become future psychiatrist-scientists in basic, translational, and patient-oriented research, while increasing research literacy among all psychiatry residents.","1882325 (contact); 1869054; ","FAVA, MAURIZIO  (contact); GREENFIELD, SHELLY F.;","CHAVEZ, MARK","06/01/2011","03/31/2022","ABCB1 gene; Address; Adult; Basic Science; Behavior; Big Data; Bioinformatics; Biomedical Research; career; catalyst; Center for Translational Science Activities; Clinical; clinical practice; Clinical Research; Clinical Sciences; Clinical Trials; cognitive neuroscience; cognitive system; Complex; Data; design; Development; Disease; Doctor of Philosophy; education research; education resources; Educational Curriculum; Educational workshop; effectiveness research; Electroencephalography; Enrollment; Evaluation; experience; Exposure to; faculty research; Fellowship; Financial Support; Formulation; Fostering; Funding; Future; General Hospitals; genome wide association study; Genomics; Goals; Grant; Health; health care delivery; Health Professional; Health Services Research; Healthcare; Hospital Departments; Hospitals; Human; improved; Infrastructure; Institution; interest; K-Series Research Career Programs; Knowledge; Leadership; literacy; Massachusetts; medical schools; Medical Students; member; Mental Health; Mentorship; Molecular and Cellular Biology; National Institute of Mental Health; neural circuit; neuroimaging; Neurophysiology - biologic function; Neurosciences; next generation; patient oriented; patient oriented research; Periodicity; Physicians; Program Evaluation; Program Reviews; programs; Psychiatrist; Psychiatry; Recommendation; recruit; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Research Training; Residencies; response; Rotation; Scientist; Secure; Seeds; skills; Structure; success; Talents; Time; Training; Training Programs; translational neuroscience; Translational Research; United States National Institutes of Health; Work; Writing; ","Fostering Research Mentorship and Training During Psychiatry Residency","094612","ZMH1","Special Emphasis Panel ","","","09","181065","14485","195550",""
"9966059","R43","HG","1","N","05/22/2020","05/22/2020","04/30/2021","172","R43HG010435","","RFA-HG-18-003","1R43HG010435-01A1","NHGRI:280001\","SBIR-STTR RPGs","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","SAN DIEGO","UNITED STATES","","52","129852864","US","10008060","ELECTRONIC BIOSCIENCES, INC.","CA","921214206","Project Narrative This program is aimed at developing a complete end-to-end system for targeted, high-accuracy, microsatellite characterization and quantification, including the associated sample/library preparation and data output/characterization. Our direct, electronic, nanopore-based, single-molecule, strand sequencing methodology will enable high accuracy, single nucleotide resolution, which is suitable for diagnostic/clinical applications. The developments and demonstrations performed during this program will lay the foundation for the development of improved targeted sequence preparation/isolation methods and the associated microsatellite research, which in turn will lead to the development of microsatellite-based clinical diagnostics and/or prognostics technologies, ultimately improving human health and personalized patient care.","10966916; ","SCHIBEL, ANNA ;","SMITH, MICHAEL","05/22/2020","04/30/2021","Back; base; Biological Assay; Biological Markers; Biological Sciences; Biopsy; Biotin; Buffers; cancer type; Capillary Electrophoresis; Cells; Chromosome 4; Cleaved cell; Clinical; clinical application; clinical diagnostics; Colon Carcinoma; Complex; Consensus; Consensus Sequence; Consumption; cost; Data; Data Analyses; Development; Diagnostic; Disease; DNA; DNA Restriction Enzymes; DNA Sequence; ds-DNA; Foundations; G-Quartets; Genome; genome sequencing; Genomics; Genotype; Goals; Gold; GTP-Binding Protein alpha Subunits, Gs; Guanine; Health; Heart Diseases; Human; Human Chromosomes; Human Genome; Immobilization; improved; Infection; insertion/deletion mutation; interest; Length; Libraries; Logistics; Malignant Neoplasms; Methodology; Methods; Microsatellite Instability; Microsatellite Repeats; Motor; Mutation; nanopore; next generation sequencing; novel; Nucleotides; outcome forecast; Output; Patients; personalized care; Phase; point-of-care diagnostics; Polymerase; Population; Predisposition; Preparation; prevent; Process; prognostic; prognostic assays; programs; Reader; Reading; Research; Resolution; Role; Sampling; signal processing; single molecule; Single Nucleotide Polymorphism; Small Business Innovation Research Grant; Streptavidin; Structure; Survival Rate; synthetic construct; System; Technology; Third Generation Sequencing; Time; Variant; Virus Diseases; whole genome; ","Nanopore Based Direct BAT-25 Microsatellite Sequencing","010435","ZHG1","Special Emphasis Panel ","","A1","01","","","280001",""
"9912748","R01","EY","5","N","05/21/2020","05/01/2020","04/30/2021","867","R01EY011787","GRADUATE SCHOOLS","PA-16-160","5R01EY011787-19","NEI:395525\","Non-SBIR/STTR RPGs","2020","NATIONAL EYE INSTITUTE","","NEW YORK","UNITED STATES","BIOLOGY","13","049179401","US","1833202","COLUMBIA UNIV NEW YORK MORNINGSIDE","NY","100277922","Imaging Functional Connectivity in Visual Cortex The role of coordinated neuronal activity by groups of neurons in the visual cortex is still poorly understood. In the last cycle of the grant we discovered that one can reconfigure cortical activity in mouse visual cortex using optogenetics, by imprinting and recalling artificial activity patterns, and we now propose to understand how these patterns are build and whether their manipulation can lead to changes in behavior. This work could help to understand how neural circuits in the visual cortex operate and can be altered and also help to design novel strategies to ameliorate amblyopia and cortical cerebral visual impairment by reconfiguring abnormal circuits.  ","8020146; ","YUSTE, RAFAEL ;","FLANDERS, MARTHA C","01/01/1998","04/30/2022","3-Dimensional; Amblyopia; Anatomy; Animal Behavior; Animals; area striata; awake; Behavior; Behavioral; Brain; cell type; Cells; Cerebral cortex; Cerebrum; Characteristics; Child; Code; Computational algorithm; design; developmental plasticity; Discrimination; Disease; Electrophysiology (science); Epidemic; excitatory neuron; experimental study; Generations; Goals; Grant; Image; imprint; In Vitro; in vivo; Individual; Injury; Interneurons; Lead; Machine Learning; Maps; Mediating; Methods; Microscopy; Modeling; Morphology; mouse genetics; Mus; Neocortex; nerve supply; neural circuit; neural network; Neurons; novel; novel strategies; novel therapeutics; operation; Optical Methods; Optics; optogenetics; Outcome; Pathologic; Pattern; Perceptual learning; phenomenological models; photoactivation; Population; Premature Infant; Preparation; Process; programs; Property; relating to nervous system; Research; Research Personnel; response; Rest; Role; sensory discrimination; Slice; spatiotemporal; Structure; Synapses; Synaptic plasticity; Techniques; Testing; Three-Dimensional Imaging; Time; Transgenic Mice; two-photon; Vision; Visual; Visual Cortex; Visual impairment; visual stimulus; Work; ","Imaging Functional Connectivity in Visual Cortex","011787","SPC","Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section ","","","19","250000","145525","395525",""
"10131393","R21","DC","3","N","05/20/2020","04/01/2020","08/31/2020","173","R21DC018327","SCHOOLS OF MEDICINE","PA-18-906","3R21DC018327-01S1","NIDCD:27835\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS","","PITTSBURGH","UNITED STATES","INTERNAL MEDICINE/MEDICINE","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","Project Narrative The deep layers of the auditory cortex give rise to a massive projection system that innervates a variety of downstream targets. The proposed studies will rigorously characterize, both anatomically and functionally, one of the largest output pathways in the brain. This kind of cortical dissection will provide a foundation for future work that may reveal how improper regulation of neural circuits can contribute to various perceptual and neurological disorders.","14154159; ","WILLIAMSON, ROSS STEWART;","POREMBA, AMY","09/24/2019","08/31/2022","Address; Affect; Amygdaloid structure; Anatomy; Area; Arousal; Attention; Auditory; Auditory area; auditory nuclei; auditory pathway; auditory processing; auditory stimulus; Axon; Behavior; Biophysics; Biosensor; Brain; Brain region; Calcium; Caliber; cell type; Cerebral cortex; Cerebrum; Cognition; cognitive function; Corpus striatum structure; Data; Development; Dissection; experimental study; Foundations; Future; Genetic; Goals; in vivo; Individual; Inferior Colliculus; insight; Label; Learning; Locomotion; Mediating; Microscope; Midbrain structure; Monitor; Morphology; Motor Activity; Mus; nervous system disorder; neural circuit; Neurons; neuroregulation; novel; Optics; Output; Pathway interactions; Pattern; Perception; Perceptual Disorders; Physiological; Physiology; Play; Population; Population Process; Process; Property; Pupil; Rabies; Research Personnel; response; Rewards; Role; Route; selective expression; Sensory; Series; Signal Transduction; System; Techniques; Thalamic structure; Transgenic Mice; two-photon; Viral; Work; ","Functional Organization of Auditory Corticofugal Circuits","018327","","","","S1","01","17786","10049","27835",""
"9918450","R01","MH","5","N","05/18/2020","05/01/2020","04/30/2021","242","R01MH112168","SCHOOLS OF MEDICINE","PAR-14-309","5R01MH112168-04","NIMH:421237\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","NEW YORK","UNITED STATES","NEUROSCIENCES","13","078861598","US","3839801","ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI","NY","100296574","PROJECT NARRATIVE Parvalbumin-expressing (PV) GABAergic interneurons in prefrontal cortex regulate cortical function, cognition and emotionality, and their dysfunction contributes to behavioral abnormalities in schizophrenia and other psychiatric disorders. Nevertheless, little is currently know about the molecular mechanisms by which PV interneuron activity is regulated. The work proposed in this application is likely to provide important new insights into how PV interneuron activity is controlled and facilitate better understanding of the pathophysiology of psychiatric disorders in which deficiencies in these neurons has been implicated.","8033639; ","KENNY, PAUL J.;","KIM, DOUGLAS S","07/21/2017","04/30/2022","3' Untranslated Regions; Alleles; Anxiety; Attention; Autopsy; Axon; Behavior; Behavioral; Behavioral inhibition; behavioral response; Binding; Biological Assay; Bipolar Disorder; bipolar patients; Calcium-Binding Proteins; Candidate Disease Gene; cell behavior; Cells; Cognition; Cognitive; Cognitive deficits; cognitive process; Complex; conditioned fear; Control Groups; CRISPR/Cas technology; crosslink; Data; Disease; Emotional; Enterobacteria phage P1 Cre recombinase; experimental study; expression vector; Extinction (Psychology); fear memory; flexibility; Fright; Functional disorder; gamma-Aminobutyric Acid; Gene Expression; Gene Targeting; Genes; Genetic Transcription; Goals; High-Throughput Nucleotide Sequencing; hippocampal pyramidal neuron; Human; Human Genetics; Immunoblotting; Immunohistochemistry; Immunoprecipitation; in vivo; information processing; insight; Interneuron function; Interneurons; knock-down; Knockout Mice; Luciferases; Mediating; Mental Depression; Mental disorders; Messenger RNA; MicroRNAs; Midbrain structure; Molecular; Molecular Mechanisms of Action; Mus; Mutant Strains Mice; Neocortex; nerve supply; Neurons; neuropsychiatry; Nucleotides; Parvalbumins; Play; Prefrontal Cortex; Proteins; Psychotic Disorders; Published Comment; Pyramidal Cells; Regulator Genes; relating to nervous system; Reporter; response; RNA; RNA-Induced Silencing Complex; Role; Schizophrenia; Seeds; Short-Term Memory; Signal Transduction; stem; Stem cells; Stimulus; Structure; Synapses; Testing; Transcript; Translations; transmission process; Untranslated RNA; Variant; Virus; Work; ","MicroRNAs in schizophrenia","112168","ZRG1","Special Emphasis Panel ","","","04","250000","171237","421237",""
"10084646","R01","AI","7","N","05/18/2020","01/01/2020","06/30/2020","855","R01AI132634","","PA-18-590","7R01AI132634-04","NIAID:649245\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","048682157","US","1531401","SEATTLE CHILDREN'S HOSPITAL","WA","981053901","Narrative Tuberculosis, caused by Mycobacterium tuberculosis is a major global health problem with millions of deaths annually and increasing antibiotic resistance. M. tuberculosis can survive and multiply inside macrophage, the immune cells normally meant to kill pathogens. We will develop a novel high content screen to identify compounds that act against M. tuberculosis inside macrophages.","9286276; ","PARISH, TANYA ;","BOYCE, JIM P","01/01/2020","06/30/2020","","High Content Screening of Mycobacterium Tuberculosis","132634","ZRG1","Special Emphasis Panel ","","","04","355992","293253","649245",""
"9937166","P01","AG","2","N","05/22/2020","04/01/2020","03/31/2021","","P01AG002132","","PAR-18-297","2P01AG002132-39","NIA:306692\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","1891234; ","SALI, ANDREJ ;","","","","3-Dimensional; Aging; Amyloid beta-Protein; analytical ultracentrifugation; Architecture; base; Biophysics; Cells; Chemicals; Circular Dichroism Spectroscopy; Complex; Computer software; crosslink; Cryoelectron Microscopy; Data; Data Analytics; Disease; Electron Microscopy; Environment; experimental study; Fluorescence; Fluorescence Microscopy; Goals; Grain; Human; Image; In Vitro; infrared spectroscopy; Length; Libraries; light scattering; Mass Spectrum Analysis; Membrane; Methods; Microscopy; Modeling; Molecular; Molecular Conformation; molecular mechanics; Molecular Sieve Chromatography; monomer; Mutation; Negative Staining; Nerve Degeneration; NMR Spectroscopy; Nucleotides; Optics; particle; Phenotype; Point Mutation; Prions; Process; protein complex; protein protein interaction; Proteins; Proteolysis; Protocols documentation; reconstruction; Resolution; restraint; Roentgen Rays; Sampling; Scheme; Shapes; Signal Pathway; Site-Directed Mutagenesis; solid state; solid state nuclear magnetic resonance; structural biology; Structural Models; Structure; Surface; System; tau Proteins; Testing; Tomogram; Translating; TREM2 gene; TYROBP gene; X-Ray Tomography; ","Project 4: Integrative structure modeling of protein complexes in aggregation","002132","ZAG1","Special Emphasis Panel ","6197","","39","190000","116692","","306692"
"10159108","IK2","VA","5","N","05/17/2020","03/01/2020","02/28/2021","999","IK2HX002283","","RFA-HX-17-008","5IK2HX002283-03","","OTHERS","2020","Veterans Affairs","","INDIANAPOLIS","UNITED STATES","","07","608434697","US","481029","RLR VA MEDICAL CENTER","IN","462022803","Ineffective patient-provider communication is a significant contributor to mental health and healthcare disparities. Interventions to improve patient-provider communication among minority groups in VA mental health services are limited. The proposed CDA-2 project is a mixed- methods study that seeks to improve patient-provider communication, specifically, shared decision-making, (SDM), an effective patient-provider communication strategy, among racial and ethnic minority Veterans. The study will involve adaptation and testing of a patient navigation intervention to increase minority Veterans? participation in SDM, and utilization of systems redesigns methods to conduct pre-implementation planning to facilitate effective implementation and delivery of the intervention in VA mental healthcare settings. Findings from this study will contribute to VA?s efforts to improve patient-provider communication and reduce VA mental healthcare disparities.","8840368; ","ELIACIN, JOHANNE ;","","03/01/2018","02/28/2023","Address; Affect; Attention; base; cancer care; cancer health disparity; Caring; Client satisfaction; Clinical; Code; Communication; Communication Research; Conflict (Psychology); Data; Development; Discrimination; disparity reduction; Distress; effective intervention; Effectiveness; Empathy; Ensure; ethnic difference; ethnic minority population; Ethnography; evidence base; Evidence based intervention; Exclusion; experience; Feedback; Focus Groups; Fostering; Foundations; Future; Goals; Health; Health Care Costs; health care disparity; health care settings; Health Communication; health disparity; health equity; Healthcare; Healthcare Systems; Hybrids; implementation research; implementation science; improved; informant; Intervention; intervention effect; Intervention Trial; Interview; Investigator-Initiated Research; Link; Measures; medication compliance; Mental Health; Mental Health Services; Methodology; Methods; Minority; Minority Groups; Outcome; Patient Care; patient engagement; patient oriented; Patient Participation; Patient Self-Report; Patient-Centered Care; patient-clinician communication; Patient-Focused Outcomes; Patients; peer; Perception; Phase; Pilot Projects; Population; Preparation; Process; programs; Provider; provider-level barriers; Psyche structure; Quality of Care; racial and ethnic; racial difference; racial minority; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Proposals; Role; Sampling; satisfaction; Services; shared decision making; Site; skills; social culture; Social Environment; Specialist; Statistical Data Interpretation; Structure; System; system-level barriers; Testing; Training; treatment as usual; trial design; Universities; Veterans; Washington; Work; ","Improving patient-provider communication to reduce mental health disparities","002283","CDA0","HSR&D Career Development Award  ","","","03","","","",""
"9936395","R01","GM","5","N","05/21/2020","05/01/2020","04/30/2021","859","R01GM032373","SCHOOLS OF MEDICINE","PA-18-484","5R01GM032373-36","NIGMS:519772\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","LA JOLLA","UNITED STATES","OTHER BASIC SCIENCES","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","Project Narrative Humans are deficient in producing a type of cell surface sialic acid molecule called Neu5Gc, yet we incorporate it from dietary intake of red meats, and antibodies against this foreign molecule generate inflammation, which may help explain the increased risk of heart disease and cancer associated with red meat consumption. We will complete a range of novel studies ranging from basic biochemical, cell biological and physiological issues, to the diversity and significance of anti-Neu5Gc antibodies. We will also initiate detailed studies on three other kinds of sialic acid-like molecules with which similar but not identical issues arise, opening up areas of biomedically relevant research that have so far not been explored by many scientists.","1863974; ","VARKI, AJIT P;","KODURI, SAILAJA","08/01/1983","04/30/2023","Acetylation; Acids; Address; Affect; Anabolism; Animals; Antibodies; Area; Atherosclerosis; Attention; Autoantigens; Bacteria; Basic Science; Biochemical; Biochemistry; Biological; Biological Process; biological systems; Biology; Buffers; Carbon; Cell surface; cell type; Cells; Cloning; Colorectal Cancer; Complex; Coronary heart disease; Data; Dietary intake; Disease; disease diagnosis; disorder risk; Epithelial; Epithelium; Evolution; extracellular; Family; Food; Foundations; Functional disorder; Future; Glycoconjugates; Grant; Haemophilus influenzae; Health; heart disease risk; Human; human disease; human monoclonal antibodies; human tissue; Hydroxylation; In Situ; In Vitro; in vivo; Inflammation; Inflammatory Response; interest; Intrinsic factor; Italy; Knowledge; Leg; Malignant Neoplasms; Mannose; Meat; Metabolic; Metabolism; Methods; Methylation; Mission; Modification; Molecular Mimicry; Monosaccharides; mouse model; Mus; N-glycolylneuraminic acid; National Institute of General Medical Sciences; Nontypable Haemophilus influenza; novel; pathogen; Pathologic; Phenotype; Physiological; polyclonal antibody; Polysaccharides; Population Study; Prevention; Production; Prokaryotic Cells; protective effect; PubMed; red meat consumption; Research; Research Personnel; Risk; Role; Scientist; Sialic Acids; Side; Source; stereochemistry; success; sugar; Sulfate; Surface; Text; Time; Transgenic Organisms; tumor; tumor progression; United States National Institutes of Health; uptake; Variant; Vertebral column; Work; ","Biology of Sialic Acids and their Substitutions","032373","ICI","Intercellular Interactions Study Section ","","","36","330014","189758","519772",""
"10043125","R21","AI","1","N","05/20/2020","05/19/2020","04/30/2021","855","R21AI154196","","PA-19-053","1R21AI154196-01","NIAID:223750\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","Project Narrative The purpose of this project is to test the hypothesis that substantial differences between the protein synthetic machinery of T. cruzi and their human hosts can be exploited for the discovery of anti- parasitic agents for treatment of chronic infections. To test this novel hypothesis we will optimize a dual luciferase screening, fluorescent confirmation and a dual luciferase counter assays and secondary validation assay; that will enable us to identify chemical agents that specifically inhibit parasite but not human protein synthesis.","2474156; ","AKTAS, BERTAL H.;","O'NEIL, MICHAEL T","05/19/2020","04/30/2022","Acute; Adopted; Amino Acids; Antibiotics; Antineoplastic Agents; Antiparasitic Agents; Area; assay development; Bacteria; Bacterial Proteins; base; Biological; Biological Assay; Biological Process; Biology; cancer therapy; Cells; Chagas Disease; Chemical Agents; Chemicals; Chronic; chronic infection; Communities; compound 30; cost; counterscreen; Cycloheximide; Cytostatics; cytotoxic; cytotoxicity; design; Development; Diagnosis; Dimethyl Sulfoxide; drug development; Drug Targeting; Elongation Factor; Eukaryota; experience; Fostering; Gene Expression; Genetic Translation; Goals; Health; high throughput screening; Human; In Vitro; Incubated; Industry; Infection; inhibitor/antagonist; Label; Laboratories; Lead; lead optimization; lead series; Leishmania; Libraries; Life Cycle Stages; Luciferases; Mammalian Cell; Mammals; Messenger RNA; Methionine; miniaturize; Molecular Weight; Natural regeneration; novel; Oral; Oryctolagus cuniculus; Parasites; pathogen; Patients; Peer Review; Peptide Initiation Factors; Pharmaceutical Preparations; Pharmacotherapy; Positioning Attribute; Preparation; Property; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Protozoa; Publications; Renilla Luciferases; Reporter; Reporter Genes; Reporting; Reproducibility; Research; Reticulocytes; Ribosomal Proteins; Ribosomal RNA; Ribosomes; screening; small molecule libraries; Structure; Structure-Activity Relationship; Symptoms; System; Testing; Time; Toxic effect; translation assay; Translation Initiation; Translations; Trypanosoma; Trypanosoma cruzi; Tumor stage; Urea; Validation; water solubility; ","Protein Synthesis Inhibitors as anti-T. Cruzi agents","154196","ZRG1","Special Emphasis Panel ","","","01","125000","98750","223750",""
"10131351","U01","DK","3","N","05/21/2020","02/01/2020","01/31/2021","847","U01DK057182","SCHOOLS OF PUBLIC HEALTH","RFA-DK-15-501","3U01DK057182-21S1","NIDDK:109000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","MINNEAPOLIS","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","05","555917996","US","1450402","UNIVERSITY OF MINNESOTA","MN","554552070","PUBLIC HEALTH RELEVANCE: Weight loss is recommended for overweight and obese individuals with type 2 diabetes, but the long-term effects of such approaches on the issues of greatest concern to older individuals-including mortality, health care utilization and costs, diabetic complications, quality of life, and frailty-remain untested. The Look AHEAD-Extension will follow approximately 3,800 of these individuals for an additional 4.5 years to determine whether random assignment to an intensive lifestyle intervention focused on weight loss achieved through healthy eating and increased physical activity relative to a control group leads to improved long-term health in later life. This extended follow-up will provide important information about the long-term beneficial effects of a lifestyle intervention in a growing segment of the population-namely those who are older, overweight or obese, and have type 2 diabetes.","1868358; ","JEFFERY, ROBERT W;","KUCZMARSKI, ROBERT J","09/30/1999","01/31/2021","Address; adult obesity; Age; Age-Years; Aging; Ancillary Study; Biochemical; Body Weight decreased; Bone Density; Cardiovascular Diseases; Caring; Clinic Visits; Clinical; Clinical Trials; cohort; comorbidity; Complications of Diabetes Mellitus; Control Groups; cost; cost effective; Data; Data Analyses; Diabetes Mellitus; diabetic; Dimensions; Disease; Education; Elderly; Event; Face; Fatty acid glycerol esters; follow-up; frailty; functional disability; Genetic; Goals; group intervention; Guidelines; Health; Health Care Costs; health care service utilization; Healthcare; healthy aging; Healthy Eating; improved; Incidence; Independent Living; Individual; Infrastructure; Intervention; Kidney Diseases; Lead; Life; lifestyle intervention; Long-Term Effects; Longevity; Measures; medical complication; Microvascular Dysfunction; middle age; mortality; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; outcome prediction; Overweight; Participant; Pathway interactions; Patient-Focused Outcomes; Persons; Phase; Physical activity; Physical Function; Population; post intervention; primary outcome; Process; programs; Public Health; public health relevance; Publications; Quality of life; Randomized; Randomized Controlled Clinical Trials; randomized trial; Recording of previous events; Reporting; Research Project Grants; research study; resilience; secondary outcome; Subgroup; Telephone; Testing; Thinness; trial comparing; Uncontrolled Study; Weight; Weight Gain; ","08/16 Action for Health in Diabetes Extension Study Research Project","057182","ZDK1","Special Emphasis Panel ","","S1","21","70779","38221","109000",""
"9968300","T32","HD","5","N","05/22/2020","05/01/2020","04/30/2021","865","T32HD040686","SCHOOLS OF MEDICINE","PA-14-015","5T32HD040686-20","NICHD:254486\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","PITTSBURGH","UNITED STATES","INTERNAL MEDICINE/MEDICINE","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","PUBLIC HEALTH RELEVANCE: This program provides support for research training of physician-scientists specializing in the care of critically ill children with neurological crises sch as severe traumatic brain injury or anoxia from processes such as drowning or asphyxia. New therapies are desperately needed for these conditions from the field through the emergency department, intensive care unit, and rehabilitation. Our program thus attracts and trains young clinician scientists from each of these disciplines and offers training opportunities that range from basic science to clinical trials.","2275205; ","KOCHANEK, PATRICK M;","MAHOLMES, VALERIE","09/25/2000","04/30/2021","Caring; Childhood; Research; Resuscitation; ","Pediatric Neurointensive Care and Resuscitation Research","040686","ZHD1","Special Emphasis Panel ","","","20","369432","24435","254486",""
"10083537","U01","MH","3","N","05/18/2020","04/15/2020","03/31/2021","242","U01MH119736","SCHOOLS OF MEDICINE","PA-18-591","3U01MH119736-02S1","NIMH:71875\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","LOS ANGELES","UNITED STATES","NONE","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","PROJECT NARRATIVE Neuropsychiatric manifestations are common in Rare Genetic Disorders (RGDs), affecting brain development and functioning throughout the lifespan; copy number variants (CNVs) at 22q11.2 and 16p11.2 loci are among the most common RGDs impacting developmental psychopathology. We propose to capitalize on highly informative samples and integrate prospective dimensional and categorical phenotyping with whole genome sequencing across these reciprocal CNVs. This work will identify convergent risk mechanisms for developmental neuropsychiatric disorders that have relevance to the broader population.","2237816; ","BEARDEN, CARRIE E;","FRIEDMAN-HILL, STACIA","06/15/2019","03/31/2024","16p11.2; 22q11.2; adverse outcome; Affect; Algorithms; Anxiety; Anxiety Disorders; Architecture; Attention; Attention deficit hyperactivity disorder; Attentional deficit; autism spectrum disorder; base; Brain; brain behavior; case control; Categories; Clinical; clinical Diagnosis; clinical phenotype; clinical predictors; Cognition; Cognitive; cohort; Collaborations; Complement; Complex; Computing Methodologies; Copy Number Polymorphism; Custom; Data; Data Analytics; Development; Developmental Course; Developmental Delay Disorders; Diagnosis; Dimensions; Disease; Early Intervention; Emotional; Emotions; Environment; Environmental Risk Factor; Evaluation; experience; externalizing behavior; Family; Family member; Genes; Genetic; genetic architecture; Genetic Determinism; genetic pedigree; Genetic Predisposition to Disease; Genetic study; genetic variant; genome sequencing; genome wide association study; Genomics; Goals; Heterogeneity; Hyperactive behavior; Individual; Institution; Intellectual functioning disability; interest; International; Knowledge; large datasets; Lead; Literature; Longevity; Measures; Memory; Mental Depression; Mind; Modeling; Molecular; National Institute of Mental Health; Nature; neurobehavioral; Neurocognition; neuropsychiatric disorder; neuropsychiatry; Online Systems; Outcome; Patients; personalized approach; phenomics; Phenotype; Population; Positioning Attribute; processing speed; prospective; Psychiatric Diagnosis; Psychopathology; Psychotic Disorders; Public Domains; rare genetic disorder; rare variant; recruit; Recurrence; Resources; Risk; risk prediction model; Sampling; Schizophrenia; social; Social Behavior; Specificity; Structure; symptomatology; Symptoms; Syndrome; theories; tool; Variant; whole genome; Work; ","3/9 Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders","119736","ZMH1","Special Emphasis Panel ","","S1","02","46074","25801","71875",""
"10043269","R21","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R21AI154187","SCHOOLS OF MEDICINE","PA-19-053","1R21AI154187-01","NIAID:251250\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW HAVEN","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","03","043207562","US","9420201","YALE UNIVERSITY","CT","065208327","8. PROJECT NARRATIVE Late loss of transplanted kidneys is caused primarily by an immune-mediated process called chronic rejection that is unresponsive to the medications used to control acute rejection. The details of the immunological process responsible for chronic rejection are unclear, but invasion of the graft by B lymphocytes increases the risk and is therefore likely to be a contributing factor. We propose to determine mechanisms responsible for recruiting B cells to the transplanted organ and determine how this process might be reduced or prevented, leading to a new therapeutic approach.","6437805; 1930382 (contact); ","MANES, THOMAS DAVID; POBER, JORDAN S (contact);","BRIDGES, NANCY D","05/21/2020","04/30/2022","Ablation; Acute; adhesion process; adhesion receptor; Adhesives; Alloantigen; Allografting; Animal Model; Antibodies; Antigen Presentation; Antigens; Archives; B-Lymphocytes; Blood Circulation; Blood Vessels; CD3 Antigens; Cell Adhesion Molecules; Cell physiology; cell type; chemokine; chemokine receptor; Chronic; Clinical Trials; Cloning; Complement; crosslink; cytokine; Data; effective therapy; Endothelial Cells; Event; Goals; high dimensionality; Human; human migration; Immune; Immune system; Immunocompromised Host; Immunofluorescence Immunologic; Immunofluorescence Microscopy; Immunologics; Immunosuppression; In Vitro; in vitro Assay; in vitro Model; Individual; Infiltration; insight; Intervention; kappa opioid receptors; kidney allograft; Kidney Transplantation; Lasers; Light; Mediating; Memory; Microfluidics; Microscopy; migration; Migration Assay; Molecular Target; monolayer; Mus; novel therapeutic intervention; Organ Transplantation; outcome forecast; Pathogenesis; Pathway interactions; Pattern; Periodicity; peripheral blood; Pharmaceutical Preparations; Plasma Cells; Plasmablast; Population; prevent; Process; receptor; Receptor Signaling; Receptors, Antigen, B-Cell; recruit; response; Risk; Sampling; Signal Transduction; Source; Specificity; T cell response; T memory cell; T-Cell Receptor; T-Lymphocyte; Techniques; tertiary lymphoid organ; Testing; Therapeutic; Tissues; Work; ","Human B cell infiltration into allografts: mechanisms and molecules","154187","TTT","Transplantation, Tolerance, and Tumor Immunology Study Section ","","","01","150000","101250","251250",""
"9930461","P01","GM","5","N","05/20/2020","05/01/2020","04/30/2021","","P01GM099134","","PAR-13-280","5P01GM099134-09","NIGMS:451449\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","8592385; ","HOCHEDLINGER, KONRAD ;","","","","Affect; Binding; Bioinformatics; Biological Assay; Biology; Cell Fate Control; Cell Line; cell type; Cells; ChIP-seq; Chromatin; Chromatin Structure; Collaborations; Complement; design; Disease; Dissection; dynamic system; Enzymes; Epiblast; Epigenetic Process; experimental study; follow-up; Gene Expression; Gene Silencing; Generations; Genetic; Genetic Transcription; genome-wide; Germ Layers; Goals; Heterochromatin; Heterogeneity; histone modification; Histones; Human; induced pluripotent stem cell; insight; Lead; Link; Mammalian Cell; Maps; Messenger RNA; Molecular; Mus; novel; novel strategies; Pattern; Phenocopy; Phenotype; Play; pluripotency; Poly A; Polyadenylation; Polyadenylation Pathway; prevent; Process; programs; promoter; protein function; Proteins; Proteomics; recruit; Regulation; Reporter; Reporting; RNA interference screen; RNA Processing; Role; Signal Transduction; Site; small hairpin RNA; Somatic Cell; Stem cells; Sumoylation Pathway; System; Testing; Therapeutic; Tissues; tool; transcription factor; Transcription Process; Transcriptional Activation; Transgenic Organisms; ","Roles of sumoylation and alternative polyadenylation in cellular reprogramming","099134","ZRG1","Special Emphasis Panel ","6050","","09","451449","0","","451449"
"10056954","R21","AI","1","N","05/20/2020","05/20/2020","04/30/2021","855","R21AI148949","SCHOOLS OF ARTS AND SCIENCES","PA-18-048","1R21AI148949-01A1","NIAID:232327\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","Chicago","UNITED STATES","BIOCHEMISTRY","09","160079455","US","6144601","NORTHWESTERN UNIVERSITY","IL","606114579","Narrative Zika virus infections are associated with a greater incidence of microcephaly and Guillain Barré syndrome in the children of women infected during pregnancy. Despite intense research efforts, there are currently no cures for Zika virus infection or specific treatments available, and Zika virus remains a serious public health concern. The proposed research project will identify the means by which Zika virus hides from the immune system, and will identify new chemical compounds for use as anti-Zika virus therapy.","1904007; ","HORVATH, CURT M;","DAVIS, MINDY I","05/20/2020","04/30/2022","Address; Aedes; American; Antiviral Agents; antiviral immunity; Antiviral Response; Antiviral Therapy; asexual; Automobile Driving; base; Biological Assay; Cells; Cellular Assay; cellular targeting; Chemicals; Child; Coupled; Culicidae; Dengue Virus; design; Disease Outbreaks; Enzymes; Epidemic; experimental study; Flavivirus; follow-up; Foundations; Future; Genes; Genetic; Genetic Transcription; Goals; Guillain-Barré Syndrome; high risk; high throughput screening; Human; Immune Evasion; Immune response; Immune system; Immunosuppression; Incidence; Individual; Infection; innovation; insight; Interferon Suppression; interferon therapy; Interferons; International; Intervention; Investigation; Knowledge; Libraries; Life Cycle Stages; Mediating; Medical; Microcephaly; Microscopic; Molecular; Molecular Analysis; Molecular Probes; monocyte; North America; novel; novel therapeutics; Pacific Islands; Pathogenesis; pathogenic virus; Pathogenicity; Pathway interactions; Penetration; Pregnancy; Prophylactic treatment; Proteins; Public Health; Reproducibility; Research; Research Project Grants; Resistance; response; Risk; Safety; screening; Signal Transduction; small molecule; South America; STAT2 gene; success; System; targeted treatment; Techniques; Therapeutic; Therapeutic Intervention; Tissues; transmission process; Travel; Tropism; ubiquitin ligase; Uganda; vaccination strategy; vector mosquito; virology; Virulence; Virulence Factors; Virus; Virus Replication; Woman; ZIKA; Zika Virus; ZIKV disease; ZIKV infection; ","Mechanisms and Modifiers of Zika Virus Innate Immune Evasion","148949","VIRB","Virology - B Study Section ","","A1","01","150000","82327","232327",""
"9903275","R01","DA","5","N","05/20/2020","04/01/2020","03/31/2021","279","R01DA047867","SCHOOLS OF MEDICINE","RFA-HD-18-036","5R01DA047867-03","NIDA:658011\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","CHAPEL HILL","UNITED STATES","OBSTETRICS & GYNECOLOGY","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","PROJECT NARRATIVE This study will compare medically-supervised withdrawal (MSW, ?detoxification?) to opioid agonist treatment (OAT) with buprenorphine for pregnant women with opioid use disorder in terms of maternal and neonatal birth outcomes. Maternal outcomes will be assessed during pregnancy, at birth and 28 days postpartum, while neonatal outcomes will be assessed at delivery. This study has the potential to impact health service policy and practices in terms of the treatment options of pregnant women with opioid use disorder.","1961086; 1857928 (contact); ","HEIL, SARAH H; JONES, HENDREE E (contact);","ANDERSON, ANN","07/15/2018","03/31/2023","Abruptio Placentae; Academic Medical Centers; Address; Agonist; Alcohol or Other Drugs use; base; Birth; Body Size; Buprenorphine; Case Management; Characteristics; Clinic; clinical care; Cohort Studies; common treatment; Comprehensive Health Care; Counseling; Data; delivery complications; Discipline of obstetrics; disorder later incidence prevention; Drug Metabolic Detoxication; Drug Screening; evidence base; Exposure to; Family; fetal; follow-up; Government; Health; Health Services; high risk population; Incidence; Individual; innovation; intraamniotic infection; Length; Length of Stay; Literature; Maintenance; maternal outcome; Medical; Medical Societies; Methodology; Morphine; Mothers; Neonatal; Neonatal Abstinence Syndrome; neonatal outcome; neonate; Opioid; opioid agonist therapy; opioid use disorder; opioid withdrawal; Outcome; Participant; Patients; Personal Satisfaction; Pharmaceutical Preparations; Pharmacological Treatment; Policies; Population; Postpartum Period; preference; Pregnancy; Pregnant Women; Premature Birth; prenatal exposure; pressure; prospective; Prospective Studies; Protocols documentation; Provider; Psychiatry; Public Health; Recommendation; Recording of previous events; recruit; Relapse; Reporting; Research; Research Design; response; Safety; Science; Services; Site; social; social factors; Social Work; standard of care; Supervision; systematic review; treatment group; Urine; Visit; Withdrawal; Woman; ","Medically-supervised withdrawal vs. agonist maintenance in the treatment of pregnant women with opioid use disorder: Maternal, fetal, and neonatal outcomes","047867","ZHD1","Special Emphasis Panel ","","","03","576772","81239","658011",""
"9889999","R01","MH","5","N","05/22/2020","03/01/2020","02/28/2021","242","R01MH109329","SCHOOLS OF ARTS AND SCIENCES","PA-13-302","5R01MH109329-05","NIMH:680053\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","CHICAGO","UNITED STATES","PSYCHOLOGY","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","PUBLIC HEALTH RELEVANCE    Public and scientific attention alike has been increasingly engaged by the relationship between some varieties of persistent antisocial behavior and treatable mental health issues. With recent large-scale research initiatives in forensic settings, we have begun to understand the disrupted neural mechanisms involved in abnormal social and emotional processes in the severely antisocial, and it is imperative to extend this work in female samples in order to better understand gender differences. With an ultimate goal of developing more effective, targeted treatment strategies, this work addresses a major public health issue in an underserved and understudied population.","8761704 (contact); 6660654; ","DECETY, JEAN  (contact); KIEHL, KENT A;","ZALCMAN, STEVEN J","06/20/2016","02/28/2021","Address; Adopted; advanced analytics; Affective; Amygdaloid structure; anti social; antisocial behavior; Antisocial Personality Disorder; AODD relapse; Attention; Awareness; base; Behavioral; behavioral outcome; Borderline Personality Disorder; Brain; Categories; Classification; Cognition; Cognitive; Communication; comorbidity; Data; Data Analyses; Diagnostic; Dimensions; Emotional; Emotions; Empathy; Etiology; experience; Face; Face Processing; falls; Female; Forensic Medicine; Functional Magnetic Resonance Imaging; Fusiform gyrus; Future; gender difference; Goals; hemodynamics; Hyperactive behavior; improved; independent component analysis; Inferior; Inferior frontal gyrus; Insula of Reil; interest; Intervention; Investigation; Jordan; Knowledge; Machine Learning; male; Measures; Mental disorders; Mental Health; mental state; Methods; Modeling; Mood Disorders; multimodality; National Institute of Mental Health; neural circuit; Neurobiology; neuroimaging; Neurologic; neuromechanism; Neurosciences; Neurosciences Research; offender; Outcome; Pain; Pathologic; Pathology; Patient Self-Report; Pattern; Perception; Personality; Population; Prefrontal Cortex; Preventive measure; Procedures; Process; Psyche structure; psychologic; Psychopath; psychopathic personality; Psychopathology; Public Health; public health relevance; relating to nervous system; remediation; Research; Research Domain Criteria; response; Rest; Sampling; showing emotion; social; social situation; specific biomarkers; Structure of superior temporal sulcus; Substance abuse problem; Substance Addiction; Suicide; Suicide attempt; symptomatology; Symptoms; System; targeted treatment; Taxonomy; Techniques; Temporal Sulcus; Testing; trait; treatment strategy; Variant; Work; ","Socioemotional processing in female offenders - Resubmission 01","109329","ZRG1","Special Emphasis Panel ","","","05","615222","64831","680053",""
"10027875","R01","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R01AI153358","GRADUATE SCHOOLS","PA-19-056","1R01AI153358-01","NIAID:734361\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CAMBRIDGE","UNITED STATES","CHEMISTRY","05","082359691","US","3212901","HARVARD UNIVERSITY","MA","021385319","Project Narrative The research proposed here is directed towards understanding the protein machinery responsible for the biogenesis of the cell envelopes of Gram-negative bacteria and mycobacterium tuberculosis. These multi- layered envelopes are essential for survival and provide intrinsic drug resistance. A better understanding of the lipid transporters that assemble the cell envelope may lead to the discovery of inhibitors that could ultimately be developed for therapeutic uses to treat drug-resistant infections.","1883052 (contact); 10334335; ","KAHNE, DANIEL  (contact); KRUSE, ANDREW ;","MENDEZ, SUSANA","05/21/2020","04/30/2025","Acinetobacter baumannii; Address; Affinity; Amino Acids; Amino Acyl-tRNA Synthetases; Antibiotics; ATP-Binding Cassette Transporters; Bacteria; Biochemical; Biochemistry; Biogenesis; Biological Assay; Biology; Carrier Proteins; cell envelope; Cell surface; Cells; Cellular Structures; Complex; Crystallization; Data; Development; Disaccharides; Drug resistance; Escherichia coli; Face; Family; Genus Mycobacterium; Glycolipids; Gram-Negative Bacteria; Health; Human; Impairment; improved; Infection; inhibitor/antagonist; Lead; Lipid A; Lipid Binding; Lipids; Lipopolysaccharides; Maps; Membrane; Methods; Molecular Conformation; Monitor; multidisciplinary; muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol; Mycobacterium tuberculosis; Mycolic Acid; novel; novel strategies; novel therapeutics; Organism; Pathway interactions; Peptidoglycan; periplasm; Permeability; Pharmaceutical Preparations; Polymers; Polysaccharides; Process; Proteins; Public Health; Pump; Research; Resistance; resistance frequency; Role; Side; small molecule; structural biology; Structure; sugar; Surface; therapeutic development; Therapeutic Uses; tool; Toxic effect; Transmembrane Transport; transport inhibitor; Trehalose; tuberculosis treatment; Variant; Work; ","Targeting Membrane Transport Steps in Cell Envelope Assembly","153358","MSFA","Macromolecular Structure and Function A Study Section ","","","01","446091","288270","734361",""
"10063258","P30","CA","3","N","05/18/2020","04/01/2020","03/31/2021","397","P30CA138292","SCHOOLS OF MEDICINE","PAR-13-386","3P30CA138292-12S2","NCI:59999\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","ATLANTA","UNITED STATES","RADIATION-DIAGNOSTIC/ONCOLOGY","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","PROJECT NARRATIVE As the first and only NCI-designated cancer center in Georgia, the Winship Cancer Institute of Emory University (Winship) serves the state as its primary tertiary cancer care provider and its primary institution for cancer research, training, and education. Winship is an integral part of Emory University, coordinating the cancer specific research capabilities of the Emory University School of Medicine, Rollins School of Public Health, Nell Hodgson Woodruff School of Nursing, Emory College, and Emory Healthcare. Winship maintains direct responsibility to coordinate the clinical care provided to cancer patients and to oversee and coordinate the quality and multi- and trans-disciplinary nature of care with all relevant units to accomplish its mission to lessen the burden of cancer by aligning discovery and education with cancer prevention and cancer care.","9294195; ","CURRAN, WALTER J.;","HE, MIN","04/07/2009","03/31/2022","Address; African American; Animal Cancer Model; anticancer research; Area; Award; base; Basic Science; Bioinformatics Shared Resource; Biostatistics Shared Resource; Cancer Burden; cancer care; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Detection; cancer education; cancer genetics; cancer health disparity; Cancer Patient; cancer prevention; cancer therapy; care providers; Caregivers; Caring; Catchment Area; Cellular biology; clinical care; Clinical Research; Clinical Sciences; college; Comprehensive Cancer Center; Developmental Therapeutics Program; Education; Enrollment; Epigenetic Process; experience; Foundations; Funding; Genomics Shared Resource; health literacy; Healthcare; Healthcare Systems; Image; Incidence; Individual; Informatics; Infrastructure; innovation; insight; Institutes; Institution; Intervention; Knowledge; Malignant Neoplasms; medical schools; member; Mentorship; Minority Groups; Mission; Mississippi; Molecular Genetics; Nature; NCI-Designated Cancer Center; new therapeutic target; novel anticancer drug; oncology; Outcome; outcome forecast; Pathology; Pathway interactions; Patient Care; Patients; Policies; population based; Population Sciences; Positioning Attribute; Prevention; programs; Proteomics Shared Resource; Public Health Nursing; Public Health Schools; Quality of Care; Reporting; Research; Research Infrastructure; Research Project Grants; Resource Sharing; Rivers; School Nursing; therapy development; Tissues; Tobacco use; Tobacco-Related Carcinoma; Training; Training and Education; Training Programs; Translational Research; Underrepresented Minority; Underserved Population; Universities; ","Winship Cancer Institute Cancer Center Support Grant","138292","NCI","Subcommittee I - Transistion to Independence ","","S2","12","38461","21538","59999",""
"9915931","R01","GM","5","N","05/19/2020","05/01/2020","04/30/2021","859","R01GM075141","SCHOOLS OF MEDICINE","PA-16-160","5R01GM075141-15","NIGMS:319800\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","PHILADELPHIA","UNITED STATES","BIOCHEMISTRY","03","053284659","US","4050801","THOMAS JEFFERSON UNIVERSITY","PA","191074418","Project Narrative: Epigenetic inheritance lies in the heart of gene regulation during normal cell differentiation, and when changed, it contributes to development of cancer and other diseases. The mechanisms of the complicated processes involved in the conservation of chromatin structure through the cell cycle are poorly understood. By developing new experimental and conceptual approaches, we propose to address key epigenetic issues that will be beneficial for general biological and health related issues.","1901659; ","MAZO, ALEXANDER M;","ADKINS, RONALD","08/01/2005","04/30/2022","Address; base; Biological; Biological Assay; Cell Cycle; Cell Differentiation process; Cell division; Cells; Cellular Assay; Chromatin; Chromatin Structure; Complex; Conflict (Psychology); Data; Daughter; daughter cell; design; Development; Disease; DNA; DNA biosynthesis; DNA Polymerase II; DNA-Directed RNA Polymerase; drug discovery; Elongation Factor; Ensure; Epigenetic Process; epigenetic regulation; experimental study; Foundations; Future; Gene Expression; Gene Expression Regulation; Generations; Genes; Genetic Transcription; Health; Heart; Histones; Kinetics; Malignant Neoplasms; Memory; Microscopy; Modeling; Molecular Conformation; Monitor; Natural regeneration; Nature; Normal Cell; novel strategies; Nuclear; Nucleosomes; Pattern; Play; Process; programs; Proliferating; protein complex; Proteins; Publishing; recruit; Regulatory Element; Repression; Research; Resolution; restoration; RNA; RNA chemical synthesis; RNA Stability; Role; Solid; stem cell differentiation; Stem cells; TATA-Box Binding Protein; Testing; theories; Time; transcription factor; Transcriptional Elongation Factors; Transcriptional Regulation; Travel; ","Transcriptional Regulation by Epigenetic Factors","075141","DEV2","Development - 2 Study Section ","","","15","205000","114800","319800",""
"9917806","R01","HG","5","N","05/22/2020","05/01/2020","04/30/2021","172","R01HG009299","SCHOOLS OF MEDICINE","PA-16-160","5R01HG009299-04","NHGRI:382452\","Non-SBIR/STTR RPGs","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","PITTSBURGH","UNITED STATES","BIOLOGY","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","Project Narrative This research project will deliver powerful computational tools for the inference of gene and regulatory element function using patterns of convergent evolution. These tools will enable the public to identify functional elements underlying high-level biological traits, especially those of importance to human health and disease, including longevity, diet, and human development.","11978624 (contact); 7313293; ","CHIKINA, MARIA D (contact); CLARK, NATHANIEL ;","TROYER, JENNIFER L","05/01/2017","04/30/2022","accurate diagnosis; Amino Acids; Animal Model; base; Biochemical; Biological; Biological Process; Biology; blind; Candidate Disease Gene; Cells; Clinical; Cochlea; Code; Codon Nucleotides; Communities; comparative genomics; Computational algorithm; Computer software; computerized tools; Custom; Data; Data Set; Dependence; Development; Developmental Gene; Diet; Disease; DNA Sequence Alteration; ear development; Elements; Enhancers; Environment; environmental change; epigenomics; Evolution; Exhibits; Experimental Genetics; experimental study; Eye Development; fungus; Gene Expression; Genes; genetic disorder diagnosis; genetic element; Genetic Research; Genetic Transcription; Genome; genome annotation; genome browser; Genome Scan; genome-wide; genomic data; Genomics; Health; Hearing; Human; Human Development; human disease; human model; innovation; Insecta; interest; Lesion; Longevity; mammalian genome; Mammals; Measures; Medical Genetics; Methodology; Methods; Modeling; Morphology; Mutate; Mutation; Nematoda; novel; Nucleic Acid Regulatory Sequences; Pathogenicity; Patients; Pattern; Performance; Phenotype; Phylogenetic Analysis; Physiological; plant fungi; Play; pressure; programs; promoter; Proteins; Regulatory Element; Research; Research Personnel; Research Project Grants; response; Role; Statistical Computing; System; Taxonomy; Testing; Time; Tissues; tool; trait; Untranslated RNA; user-friendly; Validation; Variant; Vision; Visualization; Visualization software; web app; web based interface; Whole Organism; Work; ","Functional Annotation of Genomes via Phenotypic Convergence","009299","GVE","Genetic Variation and Evolution Study Section ","","","04","250000","132452","382452",""
"9904749","R01","MH","5","N","05/18/2020","04/01/2020","03/31/2021","242","R01MH106565","SCHOOLS OF MEDICINE","PA-13-302","5R01MH106565-05","NIMH:556145\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","Chicago","UNITED STATES","PSYCHIATRY","07","098987217","US","577703","UNIVERSITY OF ILLINOIS AT CHICAGO","IL","606124305","PUBLIC HEALTH RELEVANCE: Suicide is major public health concern. The neurobiology of suicide is not properly understood. HPA axis abnormalities are major risk factors for completed suicide and have been implicated in depression. In the proposed research we will examine the molecular mechanisms associated with the pathophysiology of adult suicide by determining the protein and gene expression and methylation (epigenetic mechanisms) of HPA axis genes in postmortem brain areas (i.e., prefrontal cortex, anterior cingulate cortex, hippocampus, and amygdala) of suicide victims, non-suicidal subjects and control subjects. These studies may provide a better understanding of the role of HPA axis in the pathophysiology of suicide.","3086389; ","PANDEY, GHANSHYAM N;","ZALCMAN, STEVEN J","04/01/2016","03/31/2021","accomplished suicide; Adrenal Glands; Adult; Amygdaloid structure; Anterior; Area; Autopsy; biological adaptation to stress; Biological Markers; Biological Psychiatry; Brain; Brain region; cingulate cortex; cingulate gyrus; cohort; corticotropin releasing factor-binding protein; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone Receptors; Data; Depressed mood; Depression and Suicide; Development; Diagnosis; DNA; DNA Methylation; DNA Modification Methylases; DNA Modification Process; DNMT3a; DNMT3B gene; Early-life trauma; Enzymes; Epigenetic Process; epigenetic regulation; Feedback; Functional disorder; Gene Abnormality; Gene Expression; Gene Expression Regulation; Genes; Genetic Transcription; Glucocorticoid Receptor; glucocorticoid receptor alpha; Hippocampus (Brain); Hypothalamic structure; hypothalamic-pituitary-adrenal axis; Immunoprecipitation; interest; Isoenzymes; Knowledge; Mental Depression; Messenger RNA; Methylation; methylation pattern; Mineralocorticoid Receptor; Molecular; mRNA Expression; Neurobiology; novel; Parahippocampal Gyrus; Patients; Pituitary Gland; Prefrontal Cortex; promoter; protein expression; Proteins; Public Health; public health relevance; pyrosequencing; Regulation; Research; Risk Factors; Role; Sampling; Schizophrenia; Serotonin; Site; Structure; Substance abuse problem; suicidal behavior; Suicide; suicide brain; suicide victim; Tacrolimus Binding Proteins; Testing; Therapeutic Agents; Transferase; ","Expression and Methylation of HPA Axis Genes in Adult Suicide Brain","106565","NPAS","Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section ","","","05","347808","208337","556145",""
"9984398","R01","GM","5","N","05/20/2020","05/01/2020","04/30/2021","859","R01GM107026","SCHOOLS OF ARTS AND SCIENCES","PA-18-484","5R01GM107026-07","NIGMS:315912\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","HADLEY","UNITED STATES","BIOLOGY","02","153926712","US","850904","UNIVERSITY OF MASSACHUSETTS AMHERST","MA","010359450","PROJECT NARRATIVE Cellular mechanisms that ensure faithful transmission of the genome during cell division are vital to normal embryonic development and the maintenance of healthy tissues through adulthood. Mistakes during cell division lead to cells acquiring an abnormal number of chromosomes ? a pathological cellular state called aneuploidy. By characterizing fundamental cell division processes, the proposed research will provide fertile ground for improving disease treatment and prevention.","8864401; ","MARESCA, THOMAS JOSEPH;","GINDHART, JOSEPH G","09/01/2013","04/30/2023","Adult; Affinity; Amino Acids; Anaphase; Aneuploidy; base; Binding; Biochemical; Biological Assay; Biophysics; cancer diagnosis; Cell division; Cell Division Process; Cell physiology; Cells; Centromere; Chromatin; chromosome missegregation; chromosome movement; chromosome number abnormality; Chromosomes; Complex; Congenital Abnormality; Disease; Drosophila genus; Elements; Embryonic Development; Ensure; experimental study; First Pregnancy Trimester; Funding; Generations; Genome; Goals; Homologous Gene; Human; human tissue; improved; In Vitro; innovation; interest; Kinetochores; Knowledge; Lead; Link; Maintenance; Mechanics; mechanotransduction; Microtubules; Mitotic Chromosome; Modeling; Molecular; Molecular Conformation; molecular mass; Names; Nature; Neoplasm Metastasis; novel; Pathologic; pointed protein; Polymers; Population; Positioning Attribute; Prevention; Proliferation Marker; Property; protein complex; protein folding; Proteins; receptor; recruit; Regulation; Regulatory Pathway; Reproducibility; Research; Role; sensor; Signal Transduction; single molecule; Sister Chromatid; Spontaneous abortion; stem; Stretching; Structure; Surface; targeted treatment; Testing; Therapeutic; Time; tissue/cell culture; Tissues; Transducers; Translating; transmission process; tumorigenesis; Work; ","Mechano-molecular regulation of kinetochore function","107026","NCSD","Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section ","","","07","210001","105911","315912",""
"9926825","K24","AT","5","N","05/18/2020","05/01/2020","04/30/2021","213","K24AT009465","","PA-16-206","5K24AT009465-04","NCCIH:176243\","OTHER RESEARCH-RELATED","2020","National Center for Complementary & Integrative Health","","BOSTON","UNITED STATES","","07","071723621","US","758101","BETH ISRAEL DEACONESS MEDICAL CENTER","MA","022155400","The focus of this research is the fundamental understanding of the role of mind-body exercises and related integrative approaches in healthcare- in particular- if, how, and for whom these multi-dimensional therapies can be helpful in improving disease states and promoting health. This K24 application will provide the support to mentor the next generation of clinical scientists in this area of integrative and mind-body medicine.","6794432; ","YEH, GLORIA Y;","MUDD, LANAY MARIE","05/01/2017","04/30/2022","Address; Adherence; Area; Award; base; Behavioral; Biometry; body-mind; Cardiovascular Diseases; Cardiovascular system; career; career development; catalyst; Chronic; Clinical; clinical efficacy; Collaborations; Complementary Health; Complex; Disease; education research; education resources; Engineering; Environment; Exercise; exercise intervention; experience; Faculty; Fellowship; Funding; Future; Grant; health care delivery; Health Promotion; Healthcare; healthy lifestyle; Hospitals; improved; Individual; innovation; Institution; Integrative Medicine; Israel; Knowledge; Leadership; Learning; Life Style; Lung; Lung diseases; Medical center; medical schools; Meditation; meetings; Mentors; Methodology; Methods; Mind-Body Intervention; Mind-Body Method; multimodality; next generation; patient oriented research; Patients; Primary Care Physician; Principal Investigator; programs; Research; research facility; Research Methodology; Research Personnel; Role; Scientist; senior faculty; Shapes; skills; Solid; success; Time; Training; training opportunity; United States National Institutes of Health; ","Mentoring and Patient-Oriented Research in Mind-Body Exercise","009465","ZAT1","Special Emphasis Panel ","","","04","163188","13055","176243",""
"9903114","F30","DK","5","N","04/27/2020","05/22/2020","05/21/2021","847","F30DK117535","SCHOOLS OF MEDICINE","PA-16-305","5F30DK117535-03","NIDDK:50520\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","Chicago","UNITED STATES","PHYSIOLOGY","07","098987217","US","577703","UNIVERSITY OF ILLINOIS AT CHICAGO","IL","606124305","PROJECT NARRATIVE  Inflammatory bowel diseases (IBD) are debilitating conditions that are becoming increasingly common, although the pathogenesis of these diseases are poorly understood and treatment remains difficult. Bile acids are important molecules for maintaining intestinal health, and their dysregulation is known to worsen the symptoms of IBD and may contribute to risk of disease development. Our proposed studies will show how epigenetic modification of DNA during fetal development contributes to bile acid dysregulation and risk of IBD in adulthood. These studies will lead to an increased understanding of IBD risk factors and may lead to the development of new treatments for IBD.","11942217; ","TICHO, ALEXANDER LOUIS;","DENSMORE, CHRISTINE L","05/22/2018","05/21/2022","absorption; Adult; Affect; Animal Model; Animals; ASBT protein; base; Bile Acid Biosynthesis Pathway; Bile Acids; Biological Assay; Carrier Proteins; Colitis; Colon; CYP7A1 gene; cytokine; Data; Development; Diarrhea; Diet; Disease; disorder risk; Distal; DNA; DNA Methylation; DNA Modification Process; drug discovery; Early identification; Early Intervention; Electrolytes; Enterocytes; Enzymes; Epigenetic Process; epigenetic regulation; Epithelial; Epithelium; Exposure to; Feedback; Fetal Development; FGF19 gene; Fluids and Secretions; Functional disorder; Gene Expression; Genes; Genetic Transcription; Half-Life; Health; Hepatic; high risk; Homeostasis; Hypermethylation; ileum; In Vitro; in vivo; in vivo imaging system; in vivo Model; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; innovation; Intestines; Lead; Link; Lipids; Liver; Luciferases; luciferin; luminal membrane; luminescence; Measures; Mediating; Messenger RNA; Methods; Methylation; Modeling; mouse model; mRNA Expression; Mus; new therapeutic target; non-invasive monitor; novel; offspring; overexpression; Pathogenesis; Pathway interactions; Patients; Phosphoric Monoester Hydrolases; Phosphotransferases; Physiological; Predisposing Factor; Predisposition; Production; promoter; Protein Kinase C; Protein Tyrosine Phosphatase; Regulation; Risk; Risk Factors; Rodent; Signal Pathway; Sodium Dextran Sulfate; Symptoms; temporal measurement; Testing; Time; time use; tool; Transgenic Mice; uptake; Weaning; ","Epigenetic regulation of bile acids in health and disease","117535","DDK","Kidney, Urologic and Hematologic Diseases D Subcommittee ","","","03","50520","","50520",""
"9868869","P01","AG","5","N","05/18/2020","03/01/2020","02/28/2021","","P01AG009524","","PAR-13-258","5P01AG009524-25","NIA:280626\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","TAMPA","UNITED STATES","","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","PUBLIC HEALTH RELEVANCE NARRATIVE- Project 3 Presbycusis, or Age -Related Hearing Loss (ARHL), is the number one communication disorder and number one neurodegenerative condition of our expanding aging population; and comprises one of the top 3 chronic medical conditions, along with arthritis and cardiovascular diseases. The vast majority of people over age 60 are affected by this progressive decline in auditory sensitivity and speech understanding, which are hallmarks of ARHL. Despite this high prevalence of ARHL, there currently are no medical treatments for preventing or reversing permanent hearing loss (ARHL or other types). The thematic focus of this proposal is modulation of presbycusis through biotherapeutics and acoustic treatments. If the experiments proposed here to test hypotheses concerning interventions to modulate the progression of presbycusis are successful, the novel results should lead to clinical trials of the efficacy of these innovative technological, acoustic and drug-related treatments.","2098075; ","WALTON, JOSEPH P;","","","","Acoustics; Acquired Deafness; Acute; Address; Affect; Age; age effect; aged; Aging; aging auditory system; aging brain; aging population; Aldosterone; Animal Model; Animals; Anti-inflammatory; Arthritis; Auditory; Auditory area; auditory processing; auditory stimulus; Auditory system; base; Behavioral; Bilateral; Bilateral Hearing Loss; Biological Markers; Biological Response Modifier Therapy; Brain; Cardiovascular Diseases; Chronic; Clinical; Clinical Trials; Communication impairment; Complex; Data; Development; Disease; Ear; efficacy trial; Electrophysiology (science); Environment; experimental study; Exposure to; FDA approved; Goals; hearing impairment; High Prevalence; Hormonal; Hormones; human model; human subject; improved; Inbred CBA Mice; innovation; insight; Intervention; Investigation; Lead; Link; Measures; Medical; Methods; Midbrain structure; middle age; Molecular; Mus; Nerve Degeneration; Nervous system structure; neural correlate; Neuronal Plasticity; neurophysiology; Noise; Normal Range; novel; Pathway interactions; Peripheral; permanent hearing loss; Pharmaceutical Preparations; Play; Plug-in; Presbycusis; Prevalence; prevent; Prevention; Public Health; public health relevance; relating to nervous system; repetitive transcranial magnetic stimulation; Research; Role; Salicylic Acids; Sensorineural Hearing Loss; Serum; Signal Transduction; Sodium Salicylate; sound; Speech; Stimulus; Supplementation; Testing; Therapeutic; Therapeutic Effect; Transcranial magnetic stimulation; Unilateral Hearing Loss; young adult; ","Project 3 - Animal Neurophysiology","009524","ZAG1","Special Emphasis Panel ","5995","","25","191636","88990","","280626"
"9914150","R01","HL","5","N","05/22/2020","05/01/2020","04/30/2021","837","R01HL146603","SCHOOLS OF PHARMACY","PA-18-484","5R01HL146603-02","NHLBI:714436\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","SEATTLE","UNITED STATES","PHARMACOLOGY","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","Project Narrative Sudden cardiac arrest (SCA) is a major public health concern, accounting for up to 400,000 deaths in the US alone. This project will identify novel pathways related to H2S that will help improve prediction and identify potential new drug targets to help prevent and treat SCA.","6983923; 3077234 (contact); ","SOTOODEHNIA, NONA ; TOTAH, RHEEM ANGELA (contact);","SHI, YANG","05/01/2019","04/30/2023","Accounting; Address; Adult; Anabolism; Animal Model; Animals; Apoptosis; Arrhythmia; Atherosclerosis; Biochemical; Biocompatible Materials; Biological; Cardiac; Cardiac Electrophysiologic Techniques; Cardiac Myocytes; cardioprotection; carotid intima-media thickness; case control; Case-Control Studies; Cell physiology; Cell Survival; Cellular biology; Cessation of life; Clinical; Clinical assessments; clinical material; Cohort Studies; combat; Complex; Coronary Arteriosclerosis; coronary artery occlusion; Data; Dietary Factors; Disease; Drug Targeting; Electrophysiology (science); Environmental Pollutants; Enzymes; Erythrocyte Membrane; Etiology; Evaluation; Functional disorder; General Population; Genes; Genetic; Genetic Variation; genomic data; Genomics; Health; Heart Arrest; Heart failure; heart function; Heart Hypertrophy; Heart Injuries; Homeostasis; Human; Hydrogen Sulfide; Hypoxia; improved; in vivo; Injury; innovation; Ischemia; ischemic injury; knock-down; Link; Measurement; Measures; Mediating; Mediation; Membrane; Metabolism; Methodology; modifiable risk; Molecular; mortality; multidisciplinary; Muscle Cells; myocardial infarct sizing; Myocardial Infarction; Myocardial Ischemia; new therapeutic target; novel; Outcome; Pathologic; Pathway interactions; Patients; Pharmaceutical Preparations; Pharmacology; Phenotype; phenotypic data; Physical activity; Physiological; Plasma; Population; population based; Population Study; preservation; prevent; Prevention; Property; prospective; Public Health; Randomized; Reactive Oxygen Species; Regulation; Reperfusion Injury; Reperfusion Therapy; Research Project Grants; response; Risk; Risk Factors; Risk stratification; Role; Sampling; Signal Transduction; Signaling Molecule; small hairpin RNA; Smoking; Stress; study population; Tachyarrhythmias; Testing; Time; Tissues; Toxic effect; Transcriptional Regulation; transcriptome; transcriptome sequencing; Vasodilator Agents; Ventricular; Ventricular Fibrillation; ","Sudden cardiac arrest and circulating hydrogen sulfide","146603","CHSA","Cancer, Heart, and Sleep Epidemiology A Study Section ","","","02","499999","214437","714436",""
"10120518","R01","HL","5","N","05/21/2020","05/01/2020","04/30/2021","838","R01HL146764","SCHOOLS OF MEDICINE","PA-18-484","5R01HL146764-02","NHLBI:393750\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","LA JOLLA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","Project Narrative Chronic hypoxia causes pulmonary hypertension (PH) that is a progressive disease characterized by elevated blood pressure in the lung. Endothelial cells regulate vascular tone and dysfunction of endothelial cells is implicated in many cardiovascular diseases including hypoxia-induced PH (HPH) and diabetes. In this project, we will investigate how endothelial dysfunction in distal pulmonary arteries contributes to the development of HPH and whether diabetes or hyperglycemia alters the susceptibility and severity of HPH. This study will also help develop personalized treatment for diabetic patients living at high altitude and have hypoxic cardiopulmonary diseases.","8448292; ","MAKINO, AYAKO ;","XIAO, LEI","05/01/2019","04/30/2023","Acute; Altitude; Altitude Sickness; Alveolar; Animals; arterial stiffness; Arteries; Attenuated; base; Blood Pressure; Blood Vessels; Calcium-Activated Potassium Channel; Caliber; Cardiovascular Diseases; Cell Hypoxia; Cells; Cessation of life; Chronic; Chronic Obstructive Airway Disease; clinically relevant; connexin 40; Data; Development; Diabetes Mellitus; Diabetic mouse; diabetic patient; Distal; Down-Regulation; Electric Capacitance; Endothelial Cells; endothelial dysfunction; Endothelium; Epoprostenol; Exhibits; Functional disorder; Gap Junctions; Genes; Genetic; Goals; Heart failure; Hyperglycemia; Hypoxia; Impairment; Intercellular Junctions; Interstitial Lung Diseases; Lesion; Lung; Mediating; Messenger RNA; Molecular; Morbidity - disease rate; mortality; Mus; Muscle Contraction; Nitric Oxide; Non-Insulin-Dependent Diabetes Mellitus; overexpression; Pathogenicity; Pathologic; Patients; personalized medicine; Pharmaceutical Preparations; Population; Predisposition; pressure; Progressive Disease; Prostaglandins I; Proteins; Pulmonary artery structure; Pulmonary Heart Disease; Pulmonary Hypertension; Pulmonary Vascular Resistance; Relaxation; Reporting; Risk Factors; RNA; Role; Severities; Signal Transduction; Sleep; small molecule; Smooth Muscle; Smooth Muscle Myocytes; statistics; Systolic Pressure; Testing; vascular abnormality; vascular endothelial dysfunction; Vascular remodeling; vasoconstriction; Vasodilation; Ventricular; ","Role of Gap Junction in Hypoxia-induced Pulmonary Hypertension","146764","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","","02","250000","143750","393750",""
"10126644","R01","AI","3","N","05/18/2020","05/18/2020","08/31/2020","855","R01AI150246","SCHOOLS OF MEDICINE","PA-18-935","3R01AI150246-01S1","NIAID:111910\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","PHILADELPHIA","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Narrative Due to the dearth of antiviral therapeutics, there is an urgent need for the discovery of novel therapeutics active against emerging viruses, with this supplement focusing on SARS-CoV-2. There are no approved treatments and thus we will screen a library of approved drugs to potentially repurpose existing therapeutics for use against this emerging pathogen.","1879302; ","CHERRY, SARA ;","ALARCON, RODOLFO M","05/18/2020","08/31/2022","2019-nCoV; A549; Adjuvant; Agonist; Animal Model; Antibodies; Antiviral Agents; Autophagocytosis; base; Biological Assay; Bunyaviridae; Cells; China; Chloroquine; Clinical Trials; Coronavirus; COVID-19; cytotoxicity; Development; Disease Outbreaks; Dose; Double-Stranded RNA; Drug Screening; drug testing; Engineering; Epithelial Cells; experience; FDA approved; Filovirus; Flavivirus; Funding; Future; Goals; Grant; Hand; high throughput screening; Hour; Human; Immune; Immunity; indexing; Infection; inhibitor/antagonist; Libraries; Methods; Microscopy; Monitor; novel therapeutics; Nuclear; parent grant; pathogen; patient population; Pattern Recognition; Pharmaceutical Preparations; Positioning Attribute; Proteins; Publishing; receptor; remdesivir; Reproducibility; response; Role; Running; screening; small molecule; Stains; Testing; Therapeutic; Therapeutic Uses; Time; Vaccines; Virus; Virus Diseases; Virus Inhibitors; Work; Zika Virus; ","The role of pattern recognition and autophagy in innate anti-bunyaviral immunity","150246","","","","S1","01","69080","42830","111910",""
"9948477","F32","AA","5","N","05/19/2020","05/16/2020","05/15/2021","273","F32AA027692","SCHOOLS OF MEDICINE","PA-18-670","5F32AA027692-02","NIAAA:24176\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM","","PORTLAND","UNITED STATES","OTHER BASIC SCIENCES","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","Project Narrative Genetics significantly contribute to the risk for the development of an alcohol use disorder (AUD). The goal of this project is to identify the role of dysregulation of a part of the stress system, the glucocorticoid receptor, as a genetic risk factor for excessive alcohol consumption in both non-dependent and dependent models of drinking using genetically at-risk High Drinking in the Dark (HDID-1) mice. The results of this project will determine whether the same genetic mechanisms driving binge drinking also underlie relapse-like drinking and may identify biological targets for the prevention and treatment of AUD.","14129588; ","SAVARESE, ANTONIA ;","GRAKALIC, IVANA","05/16/2019","05/15/2021","Agonist; Air; Alcohol abuse; alcohol abuse therapy; Alcohol consumption; alcohol exposure; alcohol response; alcohol use disorder; Alcohols; Animals; Area; Automobile Driving; base; Basic Science; Behavioral Genetics; behavioral pharmacology; Bilateral; binge drinking; Biological; Blood; Brain; Breeding; Cannulas; Cannulations; Chronic; Data; Dependence; Development; Dexamethasone; Dose; drinking; Ethanol; Exhibits; experimental study; Exposure to; Failure; Fellowship; FK506 binding protein 5; Genes; Genetic; Genetic Predisposition to Disease; genetic risk factor; Genetic Transcription; Glucocorticoid Receptor; glucocorticoid receptor alpha; glucocorticoid-induced orphan receptor; Goals; Health; Heavy Drinking; high risk; high risk drinking; Hour; Implant; Infusion procedures; insight; Intoxication; Literature; Measures; Messenger RNA; Mifepristone; Modeling; Molecular; Mus; Neurobiology; new therapeutic target; Nucleus Accumbens; Pathway interactions; Patients; Peripheral; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacology; pressure; prevent; Prevention; Proteins; Rattus; receptor expression; receptor sensitivity; Relapse; Research Training; Resistance; response; Rewards; Risk; Risk Factors; Role; Saline; Severities; Signal Transduction; Societies; Stress; Study models; System; tacrolimus binding protein 4; Therapeutic Effect; Tissue-Specific Gene Expression; Training; transcriptomics; vapor; Withdrawal; Work; ","Glucocorticoid Receptor Dysregulation: a Genetic Risk Factor for Excessive Alcohol Consumption in High Drinking in the Dark (HDID-1) Mice","027692","ZAA1","Special Emphasis Panel ","","","02","24176","","24176",""
"9842406","R01","CA","5","N","05/21/2020","12/01/2019","11/30/2020","393","R01CA205633","SCHOOLS OF MEDICINE","PA-13-302","5R01CA205633-04","NCI:183047\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","MILWAUKEE","UNITED STATES","PHARMACOLOGY","05","937639060","US","46001","MEDICAL COLLEGE OF WISCONSIN","WI","532263548","Project Narrative: We propose to evaluate a widely used Chinese herbal formula Antitumor B (ATB) and its more active ATB-KAC? as potent oral cancer preventive agents. We will conduct a ?window of opportunity? (WOO) clinical trial of ATB and ATB-KAC? in patients with oral cancer. The WOO trial will be supported by mouse oral cancer chemoprevention studies to determine the efficacy of ATB-KAC? on oral carcinogenesis and compare it against ATB. We will also perform pharmacokinetic characterizations and PD/PK modeling of ATB-KAC? in both animal models and humans. We believe that the proposed studies are highly significant because future Phase II clinical prevention trials of ATB-KAC? will require vigorous characterization of its bioavailability and pharmacokinetics and the use of efficacy related biomarkers.","1955698; 6779404; 6776789 (contact); ","HU, MING ; WONG, STUART J; YOU, MING  (contact);","SZABO, EVA","12/08/2016","11/30/2022","A/J Mouse; Aftercare; Animal Model; antitumor effect; Antitumor Response; Area; arm; base; Biological; Biological Availability; Biological Markers; Blood Circulation; cancer chemoprevention; Cancer Model; Cell Proliferation; Chemicals; Chemoprevention; Chemopreventive Agent; Chinese Herbs; Chinese People; Clinical; Clinical Research; Clinical Trials; cohort; Control Groups; design; Development; Dictamnus; Dose; Drug Kinetics; Esophageal Squamous Cell Carcinoma; Exposure to; Future; Goals; Human; In Vitro; in vivo; Incidence; inhibitor/antagonist; insight; Knowledge; Lesion; liquid chromatography mass spectrometry; malignant mouth neoplasm; Malignant neoplasm of esophagus; Measures; Medicinal Herbs; Modernization; molecular marker; Molecular Target; mouse model; Mouth Neoplasms; mouth squamous cell carcinoma; Mus; neoplastic cell; Newly Diagnosed; Normal tissue morphology; novel marker; Oral; Oral Administration; oral carcinogenesis; oral lesion; Oral Leukoplakia; oral tissue; oral tumorigenesis; Pathway interactions; patient population; Patients; pharmacodynamic model; Pharmacodynamics; pharmacokinetic model; pharmacokinetics and pharmacodynamics; Phase; phase 2 study; Phase II Clinical Trials; Phytochemical; Placebo Control; Placebos; Plasma; Polygonum; pre-clinical; predictive marker; prevent; Prevention trial; Preventive; Property; Protocols documentation; Prunella vulgaris; Publishing; Randomized; Randomized Clinical Trials; Research Project Grants; Resected; response; response biomarker; Saliva; Sampling; Sonchus; Sophora; Tablets; Testing; Time; Tissues; transcriptome sequencing; Transgenic Organisms; tumor; United States; Yam - dietary; ","Inhibition of Oral Tumorigenesis by Antitumor B","205633","CDP","Chemo/Dietary Prevention Study Section ","","","04","328235","75248","183047",""
"9909367","R43","HD","1","N","04/20/2020","05/18/2020","04/30/2021","865","R43HD101181","","PAR-17-199","1R43HD101181-01","NICHD:224927\","SBIR-STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","HUNTSVILLE","UNITED STATES","","05","185169620","US","2805101","CFD RESEARCH CORPORATION","AL","358062922","Project Narrative: The novel respiratory inhalation framework proposed in this project will provide an efficient, accurate and validated computational platform to virtually test, design, and develop inhaled drug products by investigating interactions between pulmonary delivery systems and the age-specific pediatric anatomical and physiological systems at multiple scales. Applications of the proposed computational tool will reveal key aspects affecting the fate of pediatric administered drugs as well as suggesting guidelines for age-specific dose calculations in diseased states. The long term implications for the application of our developed computational tool for the entire upper and lower airways coupled with other major organs will aid in the unmet need of suggesting and standardizing pediatric inhaled drug doses and devices to deliver the most effective therapy and has the potential to change the current approach to management.","12268751; ","SINGH, NARENDER ;","LEE, JUNE","05/18/2020","04/30/2021","3-Dimensional; 8 year old; absorption; Adrenal Cortex Hormones; Adult; Aerosols; Affect; Age; age group; Anatomy; Appearance; appropriate dose; Arkansas; Asthma; asthmatic; base; Biochemical Process; Biological Availability; Biological Products; Biophysics; Birth; Blood; Caliber; Calibration; Child; Childhood; Childhood Asthma; clinical practice; Collaborations; college; computational platform; computer framework; Computer Models; Computer software; computerized tools; constriction; cost; Coupled; Data; Deposition; design; Development; Devices; Dimensions; Disease; Dose; Drug Combinations; Drug Delivery Systems; drug development; drug inhalation; Drug Kinetics; effective therapy; evaluation/testing; Formulation; Geometry; Goals; Guidelines; Human; Image; image reconstruction; improved; Inhalation; Inhalation Device; Inhalation Therapy; Inhalators; Liquid substance; Literature; Lung; Mechanics; Medicine; Metered Dose Inhaler Device; Methodology; Modeling; Modernization; National Institute of Child Health and Human Development; Nebulizer; novel; Organ; Pathologic; Patients; Pattern; pediatric department; Pharmaceutical Preparations; pharmacokinetic model; Phase; Physiological; Physiology; Population; Powder dose form; pressure; programs; Publishing; Pulmonology; Radiology Specialty; Reporting; Research; Research Personnel; Research Project Grants; Resolution; Respiration Disorders; respiratory; Respiratory Mechanics; Respiratory System; response; Safety; Scanning; simulation; Standardization; Structure; System; Testing; Therapeutic Effect; Toxic effect; United States National Institutes of Health; Universities; Validation; virtual; Water; Work; X-Ray Computed Tomography; ","A mechanism-based computational toolkit to optimize age-specific pediatric pulmonary drug delivery","101181","ZRG1","Special Emphasis Panel ","","","01","","","224927",""
"10057918","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI146500","SCHOOLS OF VETERINARY MEDICINE","PA-19-053","1R21AI146500-01A1","NIAID:222423\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","FORT COLLINS","UNITED STATES","VETERINARY SCIENCES","04","785979618","US","1725201","COLORADO STATE UNIVERSITY","CO","805232002","PROJECT NARRATIVE Severe fever with thrombocytopenia syndrome virus is an emerging infectious tick-borne disease with a relatively high mortality rate in humans. Little is known about the reservoir hosts for this virus, which limits our ability to understand transmission cycles and spread of the pathogen. The objectives of this proposal are to evaluate wildlife for host competence with the intention of utilizing this information to inform surveillance efforts in both endemic regions and predict emergence in non-endemic locations.","15079150; ","BOSCO-LAUTH, ANGELA MARIAH;","ALARCON, RODOLFO M","05/22/2020","04/30/2022","Amblyomma; American; Animals; Antibodies; Antibody titer measurement; Arboviruses; Asia; Asians; Biological Assay; Bunyaviridae; Case Fatality Rates; China; Clinical; Columbidae; Competence; Country; cross reactivity; Deer; Deer Mouse; Development; Diagnostic tests; Differential Diagnosis; Disease; Disease Surveillance; disease transmission; Domestic Animals; Early Diagnosis; Ecology; Emerging Communicable Diseases; Enzyme-Linked Immunosorbent Assay; Evaluation; Event; experimental study; Exposure to; Family; Geography; Goals; Goat; Haemaphysalis longicornis; Heartland virus; Human; human pathogen; Immersion; Immune response; Infection; Intention; interest; Japan; Knowledge; Laboratory mice; Lead; Location; Maintenance; migratory bird; Modeling; Monitor; mortality; Needles; Neutralization Tests; North America; Parasites; pathogen; Pathogenesis; Periodicity; Play; Preparation; RNA Viruses; Rodent; Role; Ruminants; Sampling; seroconversion; Serologic tests; Serological; Serum; Severe Fever with Thrombocytopenia Syndrome Virus; Source; South Korea; Specificity; Sus scrofa; Tail; Testing; tick feeding; tick-borne; Tick-Borne Diseases; Ticks; tool; transmission process; United States; vector; vector tick; Viral; Viral Pathogenesis; viral RNA; viral transmission; Viremia; Virus; Wild Animals; Zoonoses; ","Evaluation of zoonotic reservoir hosts for severe fever with thrombocytopenia syndrome virus","146500","VB","Vector Biology Study Section ","","A1","01","150000","72423","222423",""
"10139922","U54","EB","3","N","05/22/2020","05/21/2020","05/22/2021","286","U54EB027049","BIOMED ENGR/COL ENGR/ENGR STA","PA-18-591","3U54EB027049-02S1","NIBIB:6707769\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","Chicago","UNITED STATES","BIOMEDICAL ENGINEERING","09","160079455","US","6144601","NORTHWESTERN UNIVERSITY","IL","606114579","The extent and urgency of the COVID-19 pandemic requires an aggressive and innovative approach to accelerate the delivery of solutions to address immediate and future healthcare needs. Our approach augments the strong technical and clinical expertise within our own existing network of 7 African universities and their partners at Northwestern University. Our aim is to rapidly accelerate the development of promising COVID-19 technologies both in the US and globally.","2467355; 2224028 (contact); ","MCFALL, SALLY MAUREEN; MURPHY, ROBERT L (contact);","LASH, TIFFANI BAILEY","05/21/2020","05/22/2021","2019-nCoV; Accident and Emergency department; Address; Africa South of the Sahara; African; AIDS/HIV problem; Award; Back; base; Biological Assay; Biomedical Engineering; Care Technology Points; Caring; Clinic; Clinical; Communicable Diseases; COVID-19; Development; Diagnosis; Engineering; Faculty; Funding; Future; global health; Health Technology; Healthcare; Hospital Nursing; innovation; Institutes; International; low and middle-income countries; Mali; Medical; Microfluidics; Molecular; Molecular Diagnostic Testing; Needs Assessment; Nigeria; novel; Nursing Homes; pandemic disease; point of care; programs; Public Health; Research Project Grants; Sampling; scale up; Scientist; Site; South Africa; Specialist; Tanzania; Technology; technology development; Testing; Universities; University resources; urgent care; Validation; ","The Center for Innovation in Point-of-Care Technologies for HIV/AIDS at  Northwestern University (C-THAN) Supplemental Request","027049","","","","S1","02","4411084","2296685","6707769",""
"9933901","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:194867\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1878595; ","POWERS, ALVIN C;","","","","Abbreviations; Administrative Supplement; Area; career; Career Choice; career development; Clinical; Clinical Research; Communities; Country; Development; Diabetes Mellitus; E-learning; Educational Materials; Ethnic Origin; experience; Exposure to; Financial Support; follow-up; Fostering; Funding; Future; Geography; Institutes; K-Series Research Career Programs; Lead; Medical; medical schools; Medical Students; Metabolism; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Obesity; organizational structure; Outcome; outreach; Participant; Patient Care; Process; Program Evaluation; programs; Research; research and development; Research Personnel; Research Training; Resources; response; Scientist; skills; social media; Students; success; summer research; Supervision; symposium; synergism; Time; Training; Training Programs; Work; ","NIDDK Medical Student Research Program","020593","ZDK1","Special Emphasis Panel ","7653","","43","134681","60186","","194867"
"9973914","R01","HL","1","N","05/23/2020","04/01/2020","03/31/2021","837","R01HL146582","","PA-19-056","1R01HL146582-01A1","NHLBI:538864\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","COLUMBUS","UNITED STATES","","03","147212963","US","1495302","RESEARCH INST NATIONWIDE CHILDREN'S HOSP","OH","432052664","This research is highly relevant to public health because of the rapidly growing population of individual that now survive critical congenital heart defects and are expect to reach adolescence and adulthood with the possible burden of long-term neurodevelopmental deficits. Identifying the nature and timing of specific social, academic, and emotional difficulties, as well as the resources or protective factors that decrease risk, will inform new and effective interventions to optimize quality of life across the lifespan in children affected by critical CHD. This is relevant to the part of NIH?s mission that pertains to developing fundamental knowledge that will extend human life and help to reduce the burdens of illness and disability.","2266691; ","VANNATTA, KATHRYN ;","EGERSON, D'ANDREA R","04/01/2020","03/31/2024","Academic achievement; Adolescence; Adult; Affect; Affective; Age; Attention; base; Behavioral; Buffers; burden of illness; Child; Child Rearing; Childhood; Chronically Ill; cognitive skill; cohort; Common Ventricle; Congenital Heart Defects; coping; Critical Congenital Heart Defects; Cross-Sectional Studies; Cyanosis; design; Deterioration; Development; Developmental Process; Diagnosis; disability; effective intervention; elementary school; Emotional; Environment; Evaluation; Executive Dysfunction; executive function; experience; Family; fifth grade; fourth grade; Friendships; Gender; Goals; Home visitation; Human; Impairment; improved; Individual; informant; Intervention; junior high school; Knowledge; Life; Link; Longevity; Measures; Mediating; Medical; Methods; middle childhood; Mission; Morbidity - disease rate; mortality; Nature; Neurocognitive; Neurodevelopmental Deficit; Neurologic; novel; Occupational; Operative Surgical Procedures; Outcome; Parents; Pathology; Patient Self-Report; peer; Performance; Perioperative complication; Personal Satisfaction; Play; Population; post-traumatic stress; Preschool Child; protective factors; psychosocial; psychosocial development; Public Health; Quality of life; Reporting; Research; resilience; Resources; Risk; Role; School Teachers; Schools; social; Social Adjustment; Social Behavior; Social Functioning; Social Interaction; social metrics; Social Problems; social skills; Socialization; Specificity; Stress and Coping; stressor; Structure; Survivors; Symptoms; teacher; Tetralogy of Fallot; theories; Time; United States; United States National Institutes of Health; Victimization; Vulnerable Populations; Withdrawal; Work; Youth; ","Developmental Progression of Youth with Critical Congenital Heart Defects","146582","PDRP","Psychosocial Development, Risk and Prevention Study Section ","","A1","01","354516","184348","538864",""
"9927570","UC7","AI","5","N","05/19/2020","05/01/2020","04/30/2021","","UC7AI094660","","RFA-AI-15-009","5UC7AI094660-10","NIAID:674005\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","GALVESTON","UNITED STATES","","14","800771149","US","578406","UNIVERSITY OF TEXAS MED BR GALVESTON","TX","775555302","National Biocontainment Laboratories Operational Support ensures the availability of maximum containment laboratories for research that will develop the next generation of therapeutics, diagnostics and vaccines for infectious diseases that can pose a public health risk. It also ensures that high containment labs are available in the event of a public health or bioterrorism emergency. This support is essential due to the high cost of building and maintaining laboratories that protect researchers, ensure the biosecurity of dangerous pathogens, and safeguard the communities where these laboratories are located.","6916526; ","NICHOLS, JOAN E;","","","","Aerosols; Animals; biodefense; biosecurity; Bioterrorism; Communicable Diseases; Communities; Containment; cost; Dangerousness; Diagnostic; Disease; Emergency Situation; Ensure; Environmental Health; Equipment; Event; experimental study; Funding; Goals; Human Resources; Infrastructure; Institution; Laboratories; Laboratory Research; Maintenance; Medical; National Institute of Allergy and Infectious Disease; nonhuman primate; novel therapeutics; operation; pathogen; pre-clinical; Public Health; public health emergency; Regulation; Research; Research Activity; research facility; Research Personnel; Research Support; Resources; Risk; Services; Standardization; Texas; Training; Training Support; Universities; Vaccines; ","Integrated Suppport Services Core - Galveston National Laboratory BSL4 Operations","094660","ZAI1","Special Emphasis Panel ","8724","","10","436628","237377","","674005"
"9947954","T32","HD","5","N","05/22/2020","05/01/2020","04/30/2021","865","T32HD071844","","PA-16-152","5T32HD071844-08","NICHD:261654\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","PHILADELPHIA","UNITED STATES","","02","148406911","US","3988301","ALBERT EINSTEIN HEALTHCARE NETWORK","PA","191413098","Central nervous system injuries and diseases frequently lead to persistent cognitive and movement impairments that limit independence, functional abilities, and quality of life. Advances in a number of scientific domains offer new tools to improve patient assessment and rehabilitation interventions. The proposed training program, led by a group of long-standing collaborators at Moss Rehabilitation Research Institute and the University of Pennsylvania's Department of Neurology, will prepare trainees to conduct translational neurorehabilitation research that will help turn these scientific advances into feasible assessment and treatment tools that can reduce the disabling effects of neurologic disease.","1865824; ","WHYTE, JOHN ;","NITKIN, RALPH M","05/13/2013","04/30/2023","Neurorehabilitation; post-doctoral training; Research; ","Postdoctoral Training in Translational Neurorehabilitation Research","071844","ZHD1","Special Emphasis Panel ","","","08","262100","20968","261654",""
"9880436","R01","GM","5","N","05/21/2020","03/01/2020","02/28/2021","859","R01GM123181","SCHOOLS OF ARTS AND SCIENCES","PA-16-160","5R01GM123181-04","NIGMS:293983\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BERKELEY","UNITED STATES","CHEMISTRY","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947101749","Project Narrative (Public Health Relevancy Statement) Fluorinated small molecules have become a key class of structurally diverse compounds with high effectiveness in treating a broad range of human health conditions, such as cancer, bacterial and fungal infections, depression, allergies, pain, and high cholesterol. Indeed, approximately 30% of pharmaceuticals contain a fluorine atom, including over half of the top five drugs sold in the last year. Our long-term goal is to develop new methods to discover and prepare fluorinated pharmaceuticals using biological approaches that will be complementary to existing chemical methods.","8300299; ","CHANG, MICHELLE C;","FABIAN, MILES","04/01/2017","02/28/2021","Active Sites; Acyltransferase; Affect; analog; Antibiotics; Bacterial Infections; base; Behavior; Biochemical; Biological; Biological Models; Carbon; Catalysis; chemical property; Chemicals; Cholesterol; Coenzyme A; Complement; Complex; design; Development; drug candidate; Drug Design; drug discovery; effective therapy; Effectiveness; Elements; Engineering; Enzymes; Erythromycin; Escherichia coli; Event; Family; Fermentation; Fluorine; Fluoroacetates; fluoroacetyl-coenzyme A; Goals; Health; Human; Hypersensitivity; improved; In Vitro; in vivo; Individual; insight; knowledge base; Lead; Length; Link; Malignant Neoplasms; Mental Depression; Metabolism; Methods; methylmalonyl-coenzyme A; Mind; Modeling; Molecular; molecular recognition; Molecular Structure; monomer; Mycoses; Natural Products; novel strategies; novel therapeutics; Organism; Pain; Pathway interactions; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacologic Substance; polyketide synthase; preference; Preparation; Production; Property; Proteins; public health relevance; Reagent; Role; Saccharopolyspora; scaffold; Science; Site; small molecule; Streptomyces; Streptomyces lividans; Structure; synthetic biology; synthetic drug; System; Walkers; Work; ","Synthetic biology approaches to new fluorinated pharmaceuticals","123181","ZRG1","Special Emphasis Panel ","","","04","192500","101483","293983",""
"9929732","R01","NR","1","N","05/20/2020","05/20/2020","02/28/2021","361","R01NR018400","","PAR-17-496","1R01NR018400-01A1","NINR:765603\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","BOSTON","UNITED STATES","","07","005492160","US","3617301","BOSTON MEDICAL CENTER","MA","021182908","Despite the rapid expansion of advance care planning (ACP) services in the health care system, Native Hawaiians consistently have negligible rates of ACP and low use of palliative and hospice care services. To address these shortcomings, our multi-disciplinary community and research group has partnered together to create the I kua na'u 'Let Me Carry Out Your Last Wishes' ACP video intervention.","1875407; 8641729 (contact); 8605013; ","MAU, MARJORIE K. LEIMOMI MALA; PAASCHE-ORLOW, MICHAEL  (contact); VOLANDES, ANGELO ;","ADAMS, LYNN S","05/20/2020","02/28/2025","Address; Advance Care Planning; Advance Directives; Age; Ambulatory Care; Animals; Assisted Living Facilities; base; Boston; care systems; Caregivers; Caring; Clinic; Collaborations; collaborative approach; Communication; Communities; Conflict (Psychology); control trial; Counseling; Data; Decision Making; design; Development; Documentation; Elderly; Electronic Health Record; end of life; end of life care; evidence base; Exhibits; falls; Family; Family Caregiver; Focus Groups; Fostering; Friends; Funding; Future; Goals; Grant; Group Interviews; Hawaiian population; Health; health care delivery; health care disparity; health care service utilization; Health Insurance; Healthcare; Healthcare Systems; Hospice Care; hospice environment; improved; Indigenous; Individual; innovation; Insurance; Intervention; intervention program; Intervention Studies; Knowledge; Life; Literature; Medical; meetings; member; Methods; Modeling; Morbidity - disease rate; mortality; multidisciplinary; Native Hawaiian; Native-Born; non-Native; Oceans; Oral; Outcome; palliative; Palliative Care; Patient Preferences; Patients; Plants; Population; preference; Process; programs; Provider; Quality of Care; Randomized; randomized trial; Recording of previous events; recruit; Research; Research Design; response; Services; social; Surveys; Testing; therapy design; therapy development; Time; tool; Training Programs; Translating; United States National Institutes of Health; Use Effectiveness; user-friendly; Work; ","I kua na'u 'Let Me Carry Out Your Last Wishes' Advance Care Planning for Native Hawaiian Elders","018400","ZRG1","Special Emphasis Panel ","","A1","01","596905","168698","765603",""
"9992985","F31","NS","1","N","05/05/2020","05/15/2020","05/14/2021","853","F31NS115361","SCH ALLIED HEALTH PROFESSIONS","PA-19-195","1F31NS115361-01A1","NINDS:41144\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","RICHARDSON","UNITED STATES","OTHER HEALTH PROFESSIONS","32","800188161","US","578409","UNIVERSITY OF TEXAS DALLAS","TX","750803021","Narrative Cognitive impairment occurs in about 40-70% of multiple sclerosis (MS) patients with processing speed and memory impairments as the most commonly observed. Slowed processing speed may underlie memory impairments; however, the mechanisms are still under investigation. I propose to use novel calibrated functional MRI techniques, permitting measures of blood flow and neural activity, as well as structural, functional and resting-state connectivity analyses, to investigate the neurophysiology of slowed processing speed and its effects on connectivity and working memory in MS in order to understand cognitive impairments and inform treatment development.","15693712; ","ZUPPICHINI, MARK ;","UTZ, URSULA","05/15/2020","05/14/2022","Affect; Area; Astrocytes; base; Blood; Blood flow; blood oxygen level dependent; Blood Vessels; Brain; Brain region; Cerebrovascular Circulation; Cerebrum; CNS autoimmune disease; Cognitive; cognitive ability; cognitive function; Communication; Core-Binding Factor; Coupling; Delayed Memory; Diffusion; Distributed Systems; experience; Fire - disasters; Functional Magnetic Resonance Imaging; Grant; Image; Image Analysis; Imaging Techniques; Impaired cognition; Impairment; indexing; Individual Differences; Investigation; Knowledge; Letters; Magnetic Resonance Imaging; Measures; Mediating; Memory; Memory impairment; memory process; Metabolic; metabolic rate; Modeling; Motor; Multiple Sclerosis; multiple sclerosis patient; Neurons; neurophysiology; Neuropsychology; novel; Nutrient; Oligodendroglia; operation; Oxygen; Participant; Performance; Process; processing speed; relating to nervous system; Resources; response; Rest; Sensory; Short-Term Memory; Signal Transduction; Speed; Structure; Synaptic Transmission; Techniques; Testing; therapy development; Time; transmission process; Variant; white matter; ","Neurophysiologic and Connectivity Changes Associated with SlowedProcessing Speed and Working Memory Impairments in Multiple Sclerosis","115361","ZRG1","Special Emphasis Panel ","","A1","01","41144","","41144",""
"9933896","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:136048\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1888144; ","MAGNUSON, MARK A;","","","","Abbreviations; Academic Medical Centers; Animals; base; Biological Assay; blastocyst; cellular imaging; Clustered Regularly Interspaced Short Palindromic Repeats; Cryopreservation; Derivation procedure; Diabetes Mellitus; Disease; DNA; embryo cryopreservation; embryonic stem cell; Endocrine System Diseases; Fertilization in Vitro; Gene Targeting; Hormones; Human Resources; knock out mouse project; medical schools; member; Metabolic; metabolic phenotype; Microinjections; mouse model; Mus; Mutagenesis; Mutant Strains Mice; Mutation; new technology; novel therapeutics; Obesity; Pathogenesis; Physiology; Preclinical Testing; preservation; public repository; repository; Research Personnel; Research Training; Resource Sharing; Resources; RNA; Scientific Advances and Accomplishments; Services; sperm cell; sperm cryopreservation; Transgenic Mice; Universities; ","Transgenic Mouse/ES Shared Resource","020593","ZDK1","Special Emphasis Panel ","7649","","43","136048","0","","136048"
"9922307","P20","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P20GM103440","","PAR-14-233","5P20GM103440-18","NIGMS:397752\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","Bioinformatics Core - Project Narrative The Nevada INBRE Bioinformatics Core will support research investigating Cell Growth and Differentiation by (1) Continuing to serve and support basic science research state-wide with a focus on current next-generation whole-genome sequencing studies and their biomedical applications, (2) Expanding to support the design and analysis of advanced clinical studies, and (3) Implementing a strong statewide Bioinformatics Outreach and Training Program to teach, train, and mentor undergraduate students in Nevada Outreach Institutions to enable them to incorporate Big Data and advanced analytical tools into biomedical research. These aims will facilitate researchers to perform state-of-the-art biomedical research and compete successfully for NIH funding.","8675168; ","SCHLAUCH, KAREN ;","","","","advanced analytics; analytical tool; base; Basic Science; big biomedical data; Big Data; Big Data Methods; Big Data to Knowledge; Bioinformatics; Biomedical Research; causal variant; cell growth; Clinical; Clinical Research; clinically relevant; Complex; computer infrastructure; computing resources; Data; Databases; data tools; design; Differentiation and Growth; Disease; Educational workshop; Environmental Risk Factor; experience; Experimental Designs; experimental study; Funding; Generations; genome sequencing; genome wide association study; Genomic Segment; Genomics; Grant; Haplotypes; Institution; large datasets; Learning; Medical Economics; Mentors; Methods; Multivariate Analysis; Nevada; next generation; next generation sequencing; outreach; outreach program; Pathway Analysis; programs; Proteomics; Research; Research Personnel; Research Support; Resources; Services; Site; SNP array; Social Network; sound; Specific qualifier value; Statistical Data Interpretation; Students; Technology; Testing; tool; Training; Training Activity; Training Programs; transcriptome; tutoring; undergraduate student; United States National Institutes of Health; whole genome; Work; ","Bioinformatics Core","103440","ZGM1","Special Emphasis Panel ","7787","","18","308903","88849","","397752"
"9942278","U01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","838","U01HL123009","","RFA-HL-14-015","5U01HL123009-07","NHLBI:4984311\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","PUBLIC HEALTH RELEVANCE: Acute Respiratory Distress Syndrome (ARDS) is a life threatening lung condition that may develop after severe infections or trauma and requires mechanical ventilation and admission to an ICU. Each year in the United States there are an estimated 190,600 cases of ARDS which are associated with 74,500 deaths and 3.6 million hospital days. The proposed PETAL Network will seek to find the first specific treatment for ARDS or a method of prevention and has the potential to save thousands of lives annually. .","7508231; 8915131 (contact); ","SCHOENFELD, DAVID ALAN; THOMPSON, BOYD TAYLOR (contact);","REINECK, LORA A","06/17/2014","04/30/2021","acute care; Acute Lung Injury; Admission activity; Adult Respiratory Distress Syndrome; Adverse event; Biological Markers; Cessation of life; Clinical; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials Network; Cluster randomized trial; cohesion; Communication; community involvement; Computer Assisted; Critical Care; Data; data quality; data dissemination; design; Development; drug distribution; Early treatment; electronic data capture system; Ensure; experience; improved; Infection; Infrastructure; injury prevention; innovation; Institutional Review Boards; Leadership; Length of Stay; Life; Logistics; Lung; Manuscripts; Measures; Mechanical ventilation; meetings; Methods; Monitor; Morbidity - disease rate; mortality; National Heart, Lung, and Blood Institute; Newsletter; novel; Pathogenesis; patient safety; Patients; Performance; Physicians; prevent; Prevention; Prevention trial; primary endpoint; Process; Productivity; programs; Protocol Compliance; protocol development; Protocols documentation; public health relevance; Publishing; Quality Control; Randomized; Readability; Reporting; Resources; response; Risk; Sampling; Site; Statistical Data Interpretation; symposium; System; targeted treatment; Techniques; Time; Trauma; trial design; United States; web site; Writing; ","CCC for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL Network","123009","ZHL1","Special Emphasis Panel ","","","07","4267995","716316","4984311",""
"10111795","R01","HD","3","N","05/20/2020","05/01/2020","04/30/2021","865","R01HD090118","SCHOOLS OF ARTS AND SCIENCES","PA-18-591","3R01HD090118-04S1","OD:99999\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","BERKELEY","UNITED STATES","MISCELLANEOUS","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947101749","Project Narrative This project estimates the causal impact of health, skills, and financial investments made during childhood and adolescence on recipients' long-run life outcomes, as well as on the health and cognitive development of recipients' children, exploiting experimental variation to overcome the key methodological challenge of confounding. The research builds on the existing Kenya Life Panel Survey longitudinal dataset, which contains detailed information on individual health, education, social, and labor market outcomes over an exceptionally long timeframe (1998-2016). The project will extend this unusual panel dataset through 2020 for 6,500 adults and 7,200 of their children, and estimate the extent to which the youth human capital and financial interventions can improve long-run living standards, and help break the intergenerational transmission of poverty.","6687867; ","MIGUEL, EDWARD ANDREW;","BURES, REGINA M","09/15/2017","04/30/2022","5 year old; Academic achievement; Address; Adolescence; Adult; Aftercare; Age; age group; aged; Attitude; Behavioral; beneficiary; burden of illness; Businesses; Capital; Characteristics; Child; Child Development; Child Health; Childhood; Cities; Cognitive; cognitive ability; cognitive development; cost effectiveness; Costs and Benefits; Data; Data Collection; Data Set; design; Development; Discipline; Emotional; Employment; Entrepreneurship; experience; Family; Fathers; Fertility; Funding; Gender; Grant; Health; Health education; Health Status; Hour; human capital; improved; Individual; innovation; interest; intergenerational; Intervention; Interview; Investments; Kenya; Language; Life; Link; Living Standards; longitudinal dataset; Longitudinal Surveys; Marriage; Measures; Methodology; migration; Monitor; Mothers; Motor Skills; National Institute of Child Health and Human Development; nutrition; Nutritional; Outcome; Parents; Participant; Personality Traits; Pharmaceutical Preparations; Politics; Poverty; Primary Schools; Program Effectiveness; programs; Randomized; Research; Respondent; Running; Rural; Sampling; Schools; Sex Behavior; skills; skills training; social; Socioeconomic Status; success; Surveys; Training; Training Programs; transmission process; United States National Institutes of Health; Variant; Vocation; Vocational Education; voucher; Wages; Work; Youth; ","Intergenerational Impacts of Health Investments","090118","SSPB","Social Sciences and Population Studies B Study Section ","","S1","04","90901","9098","99999",""
"9948769","P51","OD","5","N","05/22/2020","05/01/2020","04/30/2021","351","P51OD011104","SCHOOLS OF MEDICINE","PAR-17-144","5P51OD011104-59","NIA:79105\OD:8391339\","RESEARCH CENTERS","2020","OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH","","NEW ORLEANS","UNITED STATES","INTERNAL MEDICINE/MEDICINE","01","053785812","US","8424601","TULANE UNIVERSITY OF LOUISIANA","LA","701185665","Project Narrative ? Overall The Tulane National Primate Research Center (TNPRC) has a mission to improve human and animal health through basic and applied biomedical research. The Center serves as a national resource for biomedical research that requires the use of nonhuman primates. Hundreds of NIH-funded investigators each year rely on the resources of the TNPRC to conduct their research.","1866413; ","HAMM, L. LEE;","HILD, SHERI ANN","05/09/1997","04/30/2023","Accreditation; animal care; animal resource; Animals; applied biomedical research; Area; base; Biomedical Research; biomedical resource; Businesses; Cellular Immunology; Communicable Diseases; Communities; Contracts; Development; Emerging Communicable Diseases; Employee; Engineering; Environment; Equipment; evidence base; experience; Faculty; Five-Year Plans; Foundations; Funding; Funding Agency; graduate student; Grant; Growth; Health; Health Sciences; Human; imaging facilities; improved; Individual; Infrastructure; interest; Laboratories; laboratory facility; Louisiana; Marketing; medical schools; Mentors; Methods; Mission; Modernization; NIH Grants and Contracts; nonhuman primate; operation; Operative Surgical Procedures; outreach; PET/CT scan; Plants; Postdoctoral Fellow; Primates; Private Sector; Privatization; Process; programs; Public Health Schools; recruit; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Schools; Science; Security; Strategic Planning; Students; System; Technology; Time; Training; Training Activity; Training and Education; Tropical Medicine; Tuberculosis; United States National Institutes of Health; Universities; vaccine evaluation; Vision; wasting; water treatment; Work; ","Tulane National Primate Research Center","011104","ZRG1","Special Emphasis Panel ","","","59","7270305","1200139","8470444",""
"9874891","R03","AI","1","N","05/12/2020","05/18/2020","04/30/2021","855","R03AI149144","SCHOOLS OF ARTS AND SCIENCES","PA-19-052","1R03AI149144-01","NIAID:72336\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","STILLWATER","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","03","049987720","US","1450502","OKLAHOMA STATE UNIVERSITY STILLWATER","OK","740781016","Project Narrative Coxiella burnetii is an obligate intracellular bacterium and the causative agent of acute Q fever and chronic diseases. It is a zoonotic pathogen which has been designated a Category B level Select Agent by the CDC. Very little is known about the molecular interactions of C. burnetii and its host cell. In the current proposal we will characterize changes in C. burnetii gene expression and eventual DNA changes in bacteria grown in cell- free media as a means to determine crucial aspects of surviving inside of a host cell. This ?reverse evolution? approach will likely lead to the identification of unique diagnostic or therapeutic targets for Q-fever detection and intervention.","8313236; ","SHAW, EDWARD I.;","PERDUE, SAMUEL S","05/18/2020","04/30/2022","Acute; Address; Animals; Bacteria; Bacterial Genes; Bacterial Proteins; base; Binding; Biology; Catalogs; Categories; Cell physiology; Cells; Cellular Stress; Centers for Disease Control and Prevention (U.S.); Chickens; Chromosomes; Chronic Disease; Citrates; Communities; comparative; Coxiella burnetii; Culture Media; Cysteine; Cytolysis; Data; Deletion Mutagenesis; Detection; Diagnostic; Disease; DNA; DNA Sequence Alteration; DNA sequencing; egg; Environment; Evolution; Face; Foundations; Funding; Future; Gene Expression; gene synthesis; Genes; Genetic; Genetic Transcription; Goals; Growth; Human; Infection; innovation; Insertional Mutagenesis; Intervention; Laboratories; Length; Libraries; Life; Methods; Molecular; Molecular Analysis; mutant; Mutation; Nature; Organism; parasitism; pathogen; Pathogenesis; Pathway interactions; Phagolysosome; Phagosomes; Phase; Phase Transition; Physiological; Process; Proteins; Proteomics; Q Fever; Research; Serial Passage; sound; Stress; stressor; System; Testing; therapeutic target; Time; transcriptome sequencing; Type IV Secretion System Pathway; Vacuole; Vesicle; Virulence; Virulent; Zoonoses; ","'Reverse Evolution' Approach to Identify Coxiella burnetii Strategies of Intracellular Survival","149144","ZRG1","Special Emphasis Panel ","","","01","50000","22336","72336",""
"9942143","R01","HD","1","N","05/18/2020","05/18/2020","03/31/2021","865","R01HD101545","","PA-18-031","1R01HD101545-01","NICHD:419793\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","BIRMINGHAM","UNITED STATES","","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","Project Narrative Hepatitis B virus is an infection that can be easily transmitted from women to newborns at the time of delivery. The REVERT-B study (Reducing Vertical Transmission of Hepatitis B in Africa) is a clinical trial designed to test a new strategy of using antiviral medication in high-risk pregnant women and newborns to reduce the risk of hepatitis B transmission. The study will measure efficacy, safety, tolerability and adherence to medication.","11299422; ","DIONNE-ODOM, JODIE ANN;","RUSSO, DENISE","05/18/2020","03/31/2025","Address; Adherence; Adverse event; Africa; Africa South of the Sahara; Age-Months; AIDS prevention; Alabama; American; Antigens; Antiviral Agents; arm; Asia; base; Birth; Breast Feeding; Cameroon; China; Chronic Hepatitis B; Cirrhosis; Clinic; Clinical Trials Design; Cold Chains; college; Conduct Clinical Trials; Country; Data; Decision Modeling; design; Diphtheria-Tetanus-Pertussis Vaccine; Discipline of obstetrics; Disease; Dose; Effectiveness; efficacy testing; Enrollment; Equipoise; experience; Flare; Follow-Up Studies; Fumarates; Goals; Guidelines; Gynecology; Health; Hepatitis B; Hepatitis B Transmission; Hepatitis B Vaccination; Hepatitis B Vaccines; Hepatitis B Virus; high risk; High Risk Woman; HIV; Immunoglobulins; Infant; Infection; Infection prevention; innovation; Intervention; Knowledge; Lamivudine; Liver diseases; Maternal and Child Health; Maternal-fetal medicine; Measures; medication compliance; Mother-to-child HIV transmission; Multi-Institutional Clinical Trial; National Institute of Child Health and Human Development; Neonatal; neonatal infection; neonate; Newborn Infant; novel; novel strategies; nucleotide analog; Oral; Outcome; Perinatal; perinatal HIV; Perinatal Infection; perinatal intervention; Perinatal transmission; Pharmaceutical Preparations; Pharmacy facility; phase III trial; Placebos; Policies; Population; Postpartum Period; Pregnancy; pregnant; Pregnant Women; prenatal; Prevalence; prevent; Prevention; Primary carcinoma of the liver cells; primary endpoint; priority pathogen; Prophylactic treatment; Publishing; Randomized; Randomized Controlled Trials; randomized placebo controlled trial; randomized trial; Recommendation; Reporting; Research; Research Design; Resources; response; Risk; Role; Safety; Series; Social Values; Societies; standard care; standard of care; success; Tenofovir; Testing; Thailand; Time; treatment as usual; trial design; United States; United States National Institutes of Health; Universities; Vaccinated; Vaccination; Vaccines; Vertical Disease Transmission; Viral Load result; Virus Diseases; virus envelope; Woman; World Health Organization; ","Reducing Vertical Transmission of Hepatitis B in Africa (REVERT-B Trial)","101545","IRAP","Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section ","","","01","298737","121056","419793",""
"9933900","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:51674\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1970983; ","GANNON, MAUREEN A;","","","","Abbreviations; Academic Medical Centers; Adult; American; Area; Awareness; base; Bicycling; career development; Childhood; Collaborations; Communities; cost; Country; Diabetes Mellitus; Education and Outreach; Endocrinology; Environment; Event; Faculty; Family; Financial Support; Fostering; Funding; General Population; Goals; graduate student; Grant; Health Professional; innovation; Institution; interest; Interest Group; Leadership; lecturer; lectures; Medical center; medical schools; Medical Students; meetings; member; Mentors; metabolic phenotype; Mission; Modeling; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; next generation; organizational structure; outreach; outreach program; Participant; posters; programs; Research; Research Personnel; Research Training; Resources; Scientist; Series; Site Visit; Source; supportive environment; symposium; Tennessee; Training; Training Activity; Training and Education; Training Programs; Training Support; Translations; Treatment outcome; undergraduate student; United States National Institutes of Health; Universities; Walking; Work; ","Enrichment, Training, and Outreach Program","020593","ZDK1","Special Emphasis Panel ","7652","","43","32705","18969","","51674"
"9991315","F32","AG","1","N","04/07/2020","05/01/2020","04/30/2021","866","F32AG067675","","PA-19-188","1F32AG067675-01","NIA:67096\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE ON AGING","","CHAPEL HILL","UNITED STATES","","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","RELEVANCE TO PUBLIC HEALTH The premise of this study is that the interaction between foot-ankle structure and function is a poorly understood, yet vastly important, biomechanical mechanism that influences walking ability and may be uniquely compromised with aging. The experimental approach combines novel dual-probe ultrasound imaging, computational modeling, and electromyography techniques to uncover the mechanisms underlying age-related differences in propulsive power during walking. The expected results will have an immediate impact on our understanding of musculoskeletal mechanisms underlying age-related mobility impairment toward improving the health and welfare of our aging population.","15901616; ","KRUPENEVICH, REBECCA LYNN;","JOSEPH, LYNDON","05/01/2020","04/30/2023","Age; age effect; age related; Aging; aging population; Animals; Ankle; aponeurosis; Behavior; Biomechanics; Characteristics; Clinical Management; Computer Models; cost; Data; design; Development; Devices; Economics; Elderly; Electromyography; Energy Metabolism; Exhibits; Fellowship; Financial compensation; foot; Gait; Generations; Health; Human; Image; Imaging Techniques; Impairment; improved; improved mobility; in vivo; Indirect Calorimetry; innovation; Intervention; Lead; Link; Locomotion; Lower Extremity; Measures; Mechanics; Mediating; Metabolic; Methods; Modeling; Muscle; Musculoskeletal; musculoskeletal imaging; negative affect; novel; Outcome; Output; Performance; Phase; Play; Postdoctoral Fellow; preservation; Public Health; Quality of life; response; Role; Structure; System; Techniques; Tendon structure; Testing; treadmill; Triceps Brachii Muscle; Ultrasonography; Walking; walking speed; welfare; Work; young adult; ","The Role of Foot Structure and Function on Walking Mechanics and Energetics in Aging","067675","ZRG1","Special Emphasis Panel ","","","01","67096","","67096",""
"9947947","T32","EY","5","N","05/19/2020","05/01/2020","04/30/2021","867","T32EY007125","SCHOOLS OF ARTS AND SCIENCES","PA-14-015","5T32EY007125-30","NEI:312066\","TRAINING, INSTITUTIONAL","2020","NATIONAL EYE INSTITUTE","","ROCHESTER","UNITED STATES","OPHTHALMOLOGY","25","041294109","US","7047101","UNIVERSITY OF ROCHESTER","NY","146270140","PUBLIC HEALTH RELEVANCE    The vision training grant provides interdisciplinary training in vision science for graduate students and post-docs of 29 faculty mentors in the Center for Visual Science at the University of Rochester. It also supports a summer undergraduate research program that attracts students from outside Rochester to spend 10 weeks in the summer working in CVS mentors' labs and attending lectures on a broad range of topics in vision science.","9213144; ","TADIN, DUJE ;","AGARWAL, NEERAJ","09/30/1990","04/30/2021","Training; vision science; ","Training in Vision Science","007125","ZEY1","Special Emphasis Panel ","","","30","314891","19794","312066",""
"10049576","R01","AI","1","N","05/18/2020","05/18/2020","01/31/2021","855","R01AI148240","","PA-19-056","1R01AI148240-01A1","NIAID:434730\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","PHILADELPHIA","UNITED STATES","","03","073757627","US","1499101","CHILDREN'S HOSP OF PHILADELPHIA","PA","191462305","NARRATIVE We have discovered an E3 ubiquitin ligase, Cul5, that becomes activated following T cell receptor stimulation and then functions in T cells to limit their differentiation into pathogenic Th2 and Th2/17 cells. Cul5 thus prevents the development of asthma following allergen exposure. We now propose studies that will reveal the biology and mechanistic underpinnings of how this ligase functions in T cells. These studies will provide molecular insight into how Th2/17 cells develop and drive pathology, and will aid the rational design of therapies that target this pathway.","9324189; ","OLIVER, PAULA MARIA;","DAVIDSON, WENDY F","05/18/2020","01/31/2025","Acute; Affect; Airway Disease; airway remodeling; Allergens; allergic airway disease; American; Antigens; Asthma; asthma model; asthmatic patient; base; Binding; Biochemical; Bioinformatics; Biological; Biology; Cell Count; Cell Differentiation process; Cell physiology; Cell Survival; Cells; Cellular biology; Cessation of life; Chronic; Clustered Regularly Interspaced Short Palindromic Repeats; Complement; Complex; Cullin Proteins; cytokine; Data; Development; Disease; Eosinophilia; Etiology; Extrinsic asthma; Fibrosis; Foundations; Glycine; Goals; Goblet Cells; Hyperplasia; In Vitro; in vivo; Individual; Inflammation; Inflammatory; insight; Interleukin-9; Ligase; Lung Inflammation; Mass Spectrum Analysis; mast cell; Mediating; Methods; Modeling; Molecular; Mouse Strains; Mus; novel; novel therapeutics; Pathogenicity; Pathology; Pathway interactions; Patients; Predisposition; prevent; Production; Proteins; Proteomics; Pyroglyphidae; receptor; recruit; Reporter; response; Role; screening; Severity of illness; Signal Pathway; small molecule; success; T cell differentiation; T-Cell Receptor; T-Lymphocyte; targeted treatment; Th2 Cells; Therapeutic; therapy design; therapy development; tool; transcriptome sequencing; Ubiquitin; ubiquitin ligase; ubiquitin-protein ligase; ","A Cul5 E3 ubiquitin ligase complex that prevents allergic asthma","148240","ZRG1","Special Emphasis Panel ","","A1","01","256629","178101","434730",""
"9922225","P01","AG","5","N","05/22/2020","05/01/2020","04/30/2021","","P01AG031719","","PAR-13-258","5P01AG031719-10","NIA:191679\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","DURHAM","UNITED STATES","","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","Is it true that males are healthier than females but die younger? If so, why? This research Project addresses these questions concerning the human health-survival paradox. Findings will provide a deeper understanding of the basis for sex differences in health and survival -- and of the opportunities that society, and particularly health professionals, have to improve health and survival for males and females.","1860078; ","VAUPEL, JAMES W.;","","","","Address; Adult; Age; age difference; Age Specific Death Rate; Aging; Agriculture; Algorithms; Animals; base; biodemography; Birds; Birth; Budgets; Caring; Categories; Cause of Death; Cessation of life; Characteristics; child bearing; Computer software; cost; Country; Data; Data Analyses; Data Set; Databases; Death Rate; Demography; Development; Differential Mortality; dimorphism; doctoral student; Environment; experience; Female; frailty; Health; health difference; Health Professional; Human; human data; human female; human male; human mortality; improved; innovation; Life; Life Expectancy; Light; Literature; Longevity; male; Malignant neoplasm of lung; Mammals; member; middle age; Modeling; mortality; mortality risk; Northern Europe; offspring; Partner in relationship; Pattern; Population; Population Heterogeneity; Postdoctoral Fellow; Predatory Behavior; Pregnancy Complications; Primates; reproductive; Research; Research Personnel; Research Project Grants; Resources; sex; Sex Differences; skeletal; Skeleton; social structure; Societies; Supervision; Testing; Time; Trees; Vertebrates; Violence; web site; Work; working group; World Health Organization; ","Project 1","031719","ZAG1","Special Emphasis Panel ","8036","","10","187092","4587","","191679"
"9989430","F30","MH","1","N","02/18/2020","03/01/2020","02/28/2021","242","F30MH120922","SCHOOLS OF MEDICINE","PA-19-191","1F30MH120922-01A1","NIMH:45059\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","NEW YORK","UNITED STATES","NEUROSCIENCES","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","PROJECT NARRATIVE Reduced desire for social interaction is a prominent feature of psychiatric and neurological disorders including autism spectrum disorder, depression, and schizophrenia, which results in social isolation that is often detrimental to a patient?s physical and mental well-being. The brain circuits that modulate sociability are poorly understood, presenting a challenge for clinicians and researchers interested in developing new treatments for these disorders. This project will explore a potential novel role for the hippocampus in sociability, as well as the underlying circuits and activity that mediate this role, and thereby present a potential novel target for circuit- based therapy of disorders with reduced social interest.","14412797; ","BOYLE, LARA MARIE;","VAN'T VEER, ASHLEE V","03/01/2020","02/29/2024","Acute; Address; Aggressive behavior; Animals; Anxiety; autism spectrum disorder; base; Behavior; Behavioral; Brain; Chronic; cognitive function; Disease; Dorsal; emotion regulation; Emotional; experimental study; Fiber; field study; flexibility; Genetic Polymorphism; Goals; hippocampal pyramidal neuron; hippocampal subregions; Hippocampus (Brain); Human; improved; interest; Intervention; Investigation; Knock-out; knockout gene; Lateral; Lead; Mediating; Memory; memory recognition; Mental Depression; Mental disorders; Molecular; Mus; nervous system disorder; Neuropeptides; Neurosciences; novel; Oxytocin; Patients; Pattern; Pharmacogenetics; Photometry; preference; receptor; receptor expression; Research; Research Personnel; Rodent; Role; Schizophrenia; social; Social Behavior; Social Desirability; Social Interaction; Social isolation; Structure; Testing; Vasopressins; way finding; Well in self; Work; ","A potential novel role for hippocampal subregion ventral CA2 in sociability","120922","ZRG1","Special Emphasis Panel ","","A1","01","45059","","45059",""
"10048069","R01","AI","1","N","05/22/2020","05/23/2020","04/30/2021","855","R01AI148160","SCHOOLS OF ARTS AND SCIENCES","PA-19-056","1R01AI148160-01A1","NIAID:561166\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CHAMPAIGN","UNITED STATES","BIOCHEMISTRY","13","041544081","US","577704","UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN","IL","618207406","NARRATIVE Staphylococcus aureus is one of the most dangerous and costly bacterial pathogens in the United States. This proposal will uncover the mechanism by which the respiratory metabolism regulates virulence and advance our understanding on the adaptive mechanisms that enable this organism to be such a versatile pathogen.","1871873; ","GENNIS, ROBERT B;","HUNTLEY, CLAYTON C","05/23/2020","04/30/2025","Aerobic; Affect; alpha Toxin; Anaerobic Bacteria; Animals; Bacteria; Biochemical; Biochemistry; Bioenergetics; Cell physiology; Cells; cost; Cytochrome c Reductase; Dangerousness; Data; detection of nutrient; Development; differential expression; Disease; Elements; Environment; Enzymes; Evolution; flexibility; Gene Expression Profiling; Generations; Genetic; Genus staphylococcus; Goals; Growth; Human body; In Vitro; Infection; interdisciplinary approach; Kinetics; Knock-out; Knowledge; Lead; Link; Longitudinal Studies; Membrane; Membrane Proteins; Metabolic; Metabolic Pathway; Metabolism; metabolomics; Methods; Microbial Biofilms; microfluidic technology; Molecular; Monitor; Morbidity - disease rate; mortality; Multi-Drug Resistance; NADH; Nebraska; new therapeutic target; Nitrates; Organ; Organism; oxidation; Oxidation-Reduction; Oxygen; pathogen; Pathogenesis; pathogenic bacteria; Pattern; Process; Production; promoter; Proteins; Proteomics; Regulation; Respiration; respiratory; Respiratory Chain; respiratory enzyme; Role; sensor histidine kinase; Signal Transduction; Signaling Molecule; Site; Staphylococcus aureus; Staphylococcus aureus infection; System; Techniques; Technology; Testing; Treatment Efficacy; United States; Universities; Variant; Virulence; Virulence Factors; Vitamin K 2; ","The molecular mechanism linking respiratory NADH oxidation and virulence in Staphylococcus aureus","148160","PCMB","Prokaryotic Cell and Molecular Biology Study Section ","","A1","01","416157","145009","561166",""
"9969899","R01","AR","1","N","05/22/2020","05/22/2020","04/30/2021","846","R01AR075730","SCHOOLS OF MEDICINE","PA-19-056","1R01AR075730-01A1","NIAMS:470864\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","SAINT LOUIS","UNITED STATES","ORTHOPEDICS","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","PROJECT NARRATIVE MicroRNAs (miRNAs) are small non-coding RNA molecules that function to suppress synthesis of a number of proteins in the cell. We have identified miRNA candidates (miR-138 and miR-181a/b-1) that regulate bone formation. These studies will determine the mechanism by which these miRNAs control bone production and address the therapeutic potential of modulating their activity in vivo to attempt to enhance bone fracture repair or inhibit abnormal bone formation (heterotopic ossification).","6809408; ","MCALINDEN, AUDREY ;","CHEN, FAYE H","05/22/2020","04/30/2025","achilles tendon; Address; Affect; Biological Assay; bone; Bone callus; bone healing; Bone Regeneration; Cell Differentiation process; Cell physiology; cell type; Cells; Chondrocytes; Chondrogenesis; Chromosome 1; clinically relevant; Computer Analysis; Data; Defect; design; Development; differential expression; Disease; Disease model; Down-Regulation; Embryo; Enzymes; Epigenetic Process; Epiphysial cartilage; FOXO1A gene; Fracture; Fracture Healing; Genes; Goals; Heterotopic Ossification; Human; In Vitro; in vivo; Inflammation; inhibitor/antagonist; Knock-in Mouse; Lead; long bone; Mediating; Messenger RNA; Metabolic; MicroRNAs; Minerals; Mitochondria; mitochondrial metabolism; Modeling; mouse model; novel; novel strategies; Orthopedics; Osteogenesis; overexpression; Oxidative Phosphorylation; Oxygen Consumption; Pathway Analysis; Pathway interactions; Pharmaceutical Preparations; Physiologic Ossification; PI3K/AKT; Population; Process; Production; progenitor; Protein Biosynthesis; Proteins; Publishing; pyruvate dehydrogenase; Pyruvate Dehydrogenase Complex; pyruvate dehydrogenase kinase 4; Regulation; repaired; Reporting; Respiration; Role; Signal Transduction; skeletal; Testing; Therapeutic; therapeutic target; Transcription Coactivator; transcriptome sequencing; Translating; Translations; Ulna Fractures; Untranslated RNA; ","MicroRNA regulation of bone formation and repair","075730","SBSR","Skeletal Biology Structure and Regeneration Study Section ","","A1","01","299199","171665","470864",""
"10148862","U01","DK","7","N","05/21/2020","05/22/2020","06/30/2020","847","U01DK061734","SCHOOLS OF MEDICINE","RFA-DK-18-505","7U01DK061734-19","NIDDK:701603\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","LA JOLLA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","Narrative Section: The Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) is a consortium of clinical centers and a Data Coordinating Center studying the cause and treatment of NASH, in order to prevent known outcomes of cirrhosis, liver transplant and liver cancer. Our studies have identified noninvasive measures for diagnosis, prognosis and prevention of disease. Our center aims to continue being the major site for the design of needed studies and enrolling the largest number of children and minorities in the Network.","9825707; ","LOOMBA, ROHIT ;","SHERKER, AVERELL H","09/15/2002","06/30/2024","","Clinical Research on Nonalcoholic Fatty Liver Disease","061734","ZDK1","Special Emphasis Panel ","","","19","516263","185340","701603",""
"10159451","P01","AI","3","N","05/18/2020","05/01/2020","04/30/2021","","P01AI091580","","PA-18-591","3P01AI091580-09S1","NIAID:107532\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","8021013; ","ROOSE, JEROEN ;","MALLIA, CONRAD M","05/18/2020","06/30/2021","","Project 2","091580","","","8191","S1","09","66998","40534","","107532"
"9999807","G11","TW","1","N","05/19/2020","05/19/2020","12/30/2020","989","G11TW011542","","PAR-19-285","1G11TW011542-01","FIC:102674\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","WASHINGTON","UNITED STATES","","98","043990498","US","2863301","GEORGE WASHINGTON UNIVERSITY","DC","200520042","Project Narrative The overall goal of the George Washington University-Kinshasa University (GWU-KU) Strengthening Ethical Review Capacity in Democratic Republic of Congo (SERC-DRC) is to strengthen operational efficiency, quality of ethical reviews and general research oversight practices of the KU School of Public Health Institutional Review Board. This will be achieved through various ways including implementation of a tracking and quality system that will begin with a formal needs assessment of bioethics related programs, teaching, institutional policies, and structures of the KUSPH-IRB, intensive mentoring of the REC administrators and members from GWU-IRB experts, participation of key members of the IRB in intensive training with GWU, participation of KU IRB members in seminars and webinars, enhancing IRB administration along with standard operating procedures through intensive technical support from African consultants, and implementation of best practices from GWU. By the end of this project, we expect to have strengthened the administrative infrastructure of KUSPH-IRB operations and in turn improved its administrative efficiency, reduced review times, and improved the quality of the review process all consistent with the mission of KUSPH and DRC to improve the KUSPH-IRB into a highly functional and well respected IRB.","7507391 (contact); 11808387; ","HYDER, ADNAN A (contact); NDEBELE, PAUL ;","BANSAL, GEETHA PARTHASARATHY","05/19/2020","12/30/2022","Acquired Immunodeficiency Syndrome; Administrative Efficiency; Administrator; Africa; Africa South of the Sahara; African; Applied Skills; Assessment tool; Attention; Awareness; Bioethics; Biomedical Research; Caring; Childhood; Collaborations; Communication; Complex; Country; Democratic Republic of the Congo; Educational process of instructing; Ensure; Equipment; Ethical Issues; Ethical Review; Ethics; experience; Foundations; global health; Goals; HIV; HIV prevention trials network; Human; human subject protection; improved; Infrastructure; infrastructure development; Institution; Institutional Policy; Institutional Review Boards; Joints; Knowledge; Leadership; low and middle-income countries; member; Mentors; Mission; Modeling; Needs Assessment; operation; Participant; Performance; Persons; Policies; Population; Positioning Attribute; Procedures; Process; professor; programs; Protocols documentation; Public Health Schools; Research; Research Ethics; Research Infrastructure; Resources; response; Schools; Site; skills; sound; Structure; System; Telephone; Time; tool; Training; Training and Infrastructure; United States National Institutes of Health; Universities; Visit; Washington; webinar; Work; ","Strengthening Ethical Review Capacity in Democratic Republic of Congo (SERC-DRC)","011542","ZRG1","Special Emphasis Panel ","","","01","96383","6291","102674",""
"10029497","R01","AI","1","N","05/20/2020","05/20/2020","04/30/2021","855","R01AI153167","","PA-19-056","1R01AI153167-01","NIAID:581911\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","PROJECT NARRATIVE Systemic lupus erythematosus (SLE) is an autoimmune disease with no known cure and limited effective therapies. A major comorbidity of SLE and common cause of death is accelerated atherosclerosis. This proposal seeks to determine whether defects in T cell metabolism underpin mechanisms for SLE autoimmunity and resulting cardiovascular disease and test two potential targets to address this unmet medical need.","6167025; 6713064 (contact); ","MAJOR, AMY S; RATHMELL, JEFFREY C. (contact);","JOHNSON, DAVID R","05/20/2020","04/30/2025","Acetyl Coenzyme A; Acetylation; Address; Affect; Affinity; alpha ketoglutarate; Anabolism; Animal Model; anti-cancer; Antigen-Antibody Complex; Arthritis; Atherosclerosis; ATP Citrate (pro-S)-Lyase; Autoantibodies; Autoimmune Diseases; Autoimmunity; autoreactive B cell; B-Lymphocytes; base; Bioenergetics; Bone Marrow; Cardiovascular Diseases; Cause of Death; CD4 Positive T Lymphocytes; Cells; Cellular Metabolic Process; Characteristics; Chimera organism; Chromatin; Chronic; chronic graft versus host disease; Citrates; Clinical Trials; comorbidity; Consumption; Coronary Arteriosclerosis; cytokine; Data; Defect; Deposition; Disease; DNA; effective therapy; Epigenetic Process; epigenetic regulation; Event; Frequencies; Gene Expression; Genetic; Glucose; Glucose Transporter; glucose uptake; Glutaminase; Glutamine; Helper-Inducer T-Lymphocyte; Histone Acetylation; histone methylation; Histones; Immune; Immunosuppression; Impairment; in vivo Model; Individual; Inflammation; Inflammatory; inhibitor/antagonist; insight; Investigation; Knock-out; Lead; Mediating; Medical; Metabolic; Metabolic Pathway; Metabolism; Methylation; Modeling; Modification; mortality; mouse model; Mus; Nephritis; new therapeutic target; novel; Pathogenicity; Pathway interactions; Patients; Pharmaceutical Preparations; Phase II Clinical Trials; Play; Production; programs; Proliferating; Publishing; Regulation; Regulatory T-Lymphocyte; response; Role; side effect; Signal Transduction; SLEB1 gene; Structure of germinal center of lymph node; Systemic Lupus Erythematosus; T cell differentiation; T cell regulation; T-Lymphocyte; T-Lymphocyte Subsets; Testing; Therapeutic; therapeutic target; Transgenic Organisms; tumor metabolism; vascular inflammation; Work; ","Targeting Tfh Cell Metabolic Regulation in SLE and SLE-Associated Atherosclerosis","153167","HAI","Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section ","","","01","352718","229193","581911",""
"9926312","R01","MH","5","N","05/20/2020","05/20/2020","04/30/2021","242","R01MH107487","UNIVERSITY-WIDE","PAR-14-309","5R01MH107487-06","NIMH:339585\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","TOLEDO","UNITED STATES","NONE","09","807418939","US","229501","UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS","OH","436142595","Narrative: This project will identify the critical elements of brain function that contribute to the pathophysiology of schizophrenia. Identification of the molecular elements underlying schizophrenia will provide new targets for the development of medicines to treat this illness.","1879270 (contact); 7056050; ","MCCULLUMSMITH, ROBERT E (contact); MELLER, JAREK ;","MEINECKE, DOUGLAS L","01/01/2019","04/30/2021","Address; Adverse effects; Anatomy; Antipsychotic Agents; Astrocytes; atypical antipsychotic; Autopsy; Basal Ganglia; base; Biochemical; Bioinformatics; Biological; Biological Assay; Brain; Brain region; brain tissue; cell type; Cells; Climacteric; Clozapine; Cognitive; Cognitive deficits; cognitive task; comparison group; Consensus; Corpus striatum structure; Coupling; Cyclic AMP-Dependent Protein Kinases; Data; Databases; Delusions; density; Development; disability; Disease; Disinhibition; Dopamine Antagonists; Dopamine D2 Receptor; drug development; Drug Targeting; Elements; Environment; Environmental Risk Factor; Equilibrium; executive function; experimental study; Expression Profiling; Failure; follow-up; frontal lobe; Functional disorder; Gene Expression; Genes; Genetic Predisposition to Disease; Genetic Transcription; Goals; Hallucinations; hippocampal pyramidal neuron; in silico; innovation; Interneurons; Intervention; knock-down; laser capture microdissection; Lead; Lesion; Libraries; Measures; Medicine; Messenger RNA; migration; Modeling; Molecular; Motivation; myelination; network models; Network-based; Neurobehavioral Manifestations; Neuronal Plasticity; Neurons; Neuropil; neurotransmission; new therapeutic target; novel; novel therapeutics; Parvalbumins; Pathologic; Pathway interactions; Persons; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacology; Phenotype; Phosphoproteins; Phosphotransferases; Population; Prefrontal Cortex; Protein Kinase; Proteomics; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Rodent; Sampling; Schizophrenia; Serine; severe mental illness; Short-Term Memory; side effect; Signal Pathway; Signal Transduction; small molecule; Standardization; Symptoms; Synaptic plasticity; Synaptic Transmission; Techniques; Testing; Thalamic structure; Threonine; treatment strategy; Vertebral column; young adult; ","Cell-specific analysis of sub-kinomes in schizophrenia","107487","ZRG1","Special Emphasis Panel ","","","06","250000","89585","339585",""
"9921221","U54","MD","5","N","05/18/2020","04/01/2020","03/31/2021","","U54MD010722","","RFA-MD-15-013","5U54MD010722-05","NIMHD:542177\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","2404525; ","CARRASQUILLO, OLVEEN ;","","","","African American; Area; Attenuated; Award; base; cancer health disparity; care systems; Chronic; Clinical Data; Collaborations; Communities; community based participatory research; community involvement; community organizations; design; Discipline; disorder prevention; Educational Activities; effective intervention; Ensure; Ethics; ethnic diversity; ethnic minority population; Event; experience; Failure; Florida; Fostering; Funding; Goals; Health; health disparity; health equity; Health Priorities; Health Promotion; Health Sciences; improved; Incidence; Individual; Infrastructure; infrastructure development; Institutes; Institution; interest; Investments; Latino; Lead; member; mortality; novel; novel strategies; Outcome; Outreach Research; Patients; personalized approach; Persons; population health; precision medicine; Process; Productivity; programs; racial and ethnic; racial diversity; recruit; Research; Research Activity; research and development; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Science; Seeds; skills; Structure; Universities; uptake; user-friendly; Vulnerable Populations; willingness; ","Consortium Core","010722","ZMD1","Special Emphasis Panel ","8200","","05","420367","121810","","542177"
"9922304","P20","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P20GM103440","","PAR-14-233","5P20GM103440-18","NIGMS:623104\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","Administrative Core - Project Narrative The Administrative Core provides logistical support and financial management to all NV INBRE programs and activities to facilitate the training of the next generation of biomedical researchers, enhance nationally- competitive biomedical research in Nevada, and ultimately improve the health of Nevadans.","1896564; ","KENYON, JAMES L;","","","","Advisory Committees; Bioinformatics; Biomedical Research; cell growth; Communication; Core Facility; Databases; Development; Differentiation and Growth; Education; Educational process of instructing; Evaluation; faculty mentor; faculty research; Funding; Grant; Health; improved; Institution; Link; Logistics; Mentors; Mission; Nevada; next generation; Occupational activity of managing finances; Office of Administrative Management; organizational structure; outreach; outreach program; programs; Reporting; Research; Research Activity; Research Personnel; Research Training; Shapes; Structure; Students; Training; web site; ","Administrative Core","103440","ZGM1","Special Emphasis Panel ","7784","","18","475998","147106","","623104"
"9955344","R21","MH","5","N","05/18/2020","05/01/2020","04/30/2021","242","R21MH118675","SCHOOLS OF MEDICINE","PA-18-350","5R21MH118675-02","NIMH:193750\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","JACKSON","UNITED STATES","PSYCHIATRY","03","928824473","US","5390304","UNIVERSITY OF MISSISSIPPI MED CTR","MS","392164500","The brain mechanisms responsible for major depression involve not only neurons, but also astrocytes and oligodendrocytes, the latter forming myelin around the axons of neurons. We propose that a mechanism based on the interaction between astrocytes and the nodes of Ranvier of myelinated axons contributes to depression and could be leveraged for new antidepressant treatments.","7366913 (contact); 1960116; ","MIGUEL-HIDALGO, JOSE JAVIER (contact); RAJKOWSKA, GRAZYNA ;","MEINECKE, DOUGLAS L","06/14/2019","04/30/2021","Action Potentials; Anatomy; Animal Experiments; Animal Model; Animals; Anterior; Antidepressive Agents; Astrocytes; Autopsy; Axon; base; Behavior; Behavioral; Brain; Brain region; brain tissue; Cell Adhesion Molecules; Cells; Chronic; Corpus Callosum; CSPG4 gene; density; depression model; Diagnosis; Disease model; Ensure; Excitatory Amino Acid Transporter 1; Extracellular Matrix; Freezing; Functional disorder; GLAST Protein; gray matter; Human; Immunohistochemistry; Knowledge; Laboratories; loss of function; Major Depressive Disorder; Mental Depression; Messenger RNA; Methods; Molecular; Morphology; morphometry; Myelin; Neuraxis; neurobiological mechanism; Neuroglia; Neurons; Nodal; novel; Occipital lobe; Oligodendroglia; Pathologic; Pathology; Pathway interactions; Probability; Process; Proteins; Proteoglycan; Ranvier's Nodes; Rattus; Research; Research Support; Risk Factors; Rodent; Role; Seminal; Signal Transduction; small hairpin RNA; stem; Stress; Structure; Symptoms; Testing; Viral Vector; Western Blotting; white matter; ","Astrocytes and the pathology of nodes of Ranvier in depression","118675","PMDA","Pathophysiological Basis of Mental Disorders and Addictions Study Section ","","","02","125000","68750","193750",""
"9890172","R21","HD","1","N","05/21/2020","05/22/2020","04/30/2021","865","R21HD098086","","PA-18-482","1R21HD098086-01A1","NICHD:259749\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","KANSAS CITY","UNITED STATES","","05","073067480","US","1529501","CHILDREN'S MERCY HOSP (KANSAS CITY, MO)","MO","641084619","PROJECT NARRATIVE The burden of adolescent unintended pregnancy in the US is substantial, despite declines in pregnancy rates in recent years. Because many high-risk adolescents face multi-level barriers to contraceptive access and use, we propose using a non-traditional site ? the Emergency Department? to deliver a novel, patient-centered contraceptive counseling intervention.","9014156; ","MILLER, MELISSA KRISTINE;","KING, ROSALIND B","05/22/2020","04/30/2022","Accident and Emergency department; Address; Adolescent; Adolescent Medicine; Advanced Practice Nurse; African American; aged; arm; base; care seeking; Caring; Characteristics; child bearing; Clinic; Comprehensive Health Care; condoms; contextual factors; Contraceptive Agents; Contraceptive methods; cost; Counseling; Data; design; disparity reduction; emergency contraception; Emergency department visit; Emergency Department-based Intervention; Emergency Nursing; Enrollment; evidence base; Face; Feasibility Studies; Female; Female Adolescents; Future; Generations; Health; Health Educators; Health Services; Healthcare Systems; high risk; high-risk adolescents; Hispanics; hormonal contraception; Human Resources; Implant; Incidence; indexing; Individual; Injections; innovation; interest; Intervention; intervention participants; Knowledge; Lead; Length; Literature; Location; Methodology; Minority; Modeling; motivational enhancement therapy; novel; novel strategies; Oral; Outcome; Outpatients; Participant; patient oriented; patient-level barriers; Patients; pediatric emergency; pill; point of care; Positioning Attribute; Poverty; Pregnancy; Pregnancy in Adolescence; Pregnancy Rate; programs; Provider; provider-level barriers; randomized trial; Reporting; reproductive; Research; response; Risk; Risk Reduction; Sampling; Services; Sexual Health; sexual health intervention; sexually active; Sexually Transmitted Diseases; Site; Specialist; standard of care; System; system-level barriers; Testing; theories; Time; Training; treatment arm; unintended pregnancy; uptake; Vaginal Ring; Work; Youth; ","Multi-level Emergency Department Intervention to Reduce Pregnancy Risk Among Adolescents","098086","ZRG1","Special Emphasis Panel ","","A1","01","192982","66767","259749",""
"9922217","P01","AG","5","N","05/22/2020","05/01/2020","04/30/2021","","P01AG031719","","PAR-13-258","5P01AG031719-10","NIA:113637\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","DURHAM","UNITED STATES","","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","Is it true that males are healthier than females but die younger? If so, why? This Core supports research projects that address these questions concerning the human health-survival paradox. Findings will provide a deeper understanding of the basis for sex differences in health and survival -- and of the opportunities that society and particularly health professionals have to improve health and survival for males and females.","1860078; ","VAUPEL, JAMES W.;","","","","Address; Administrative Coordination; Aging; Budgets; Cause of Death; Certification; Charge; cohesion; Communication Tools; Data; Data Analyses; Databases; Demography; Denmark; design; Development; dissemination research; Educational workshop; Encapsulated; Ensure; Female; Funding; Gap Junctions; Goals; Health; health difference; Health Professional; Human; Human Resources; human subject; IACUC; improved; insight; Institutional Review Boards; Internet; Leadership; Maintenance; male; meetings; member; Methodology; Personnel Management; Postdoctoral Fellow; pressure; Process; programs; Protocols documentation; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resources; Services; Sex Differences; Societies; Thinness; Time; United States National Institutes of Health; Universities; Update; Vertebrates; Wages; Women's Health; Work; working group; ","Administrative Core","031719","ZAG1","Special Emphasis Panel ","8035","","10","71470","42167","","113637"
"9926324","D43","TW","5","N","05/18/2020","05/01/2020","04/30/2021","989","D43TW010562","SCHOOLS OF MEDICINE","PAR-16-279","5D43TW010562-04","FIC:218566\NIDA:80000\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","BROOKLYN","UNITED STATES","INTERNAL MEDICINE/MEDICINE","09","040796328","US","5992616","SUNY DOWNSTATE MEDICAL CENTER","NY","112032012","PROJECT NARRATIVE This NYS-ITRP HIV Research Training Program will build capacity in Ukraine to conduct implementation science research addressing HIV treatment cascade gaps. This program aims to decrease the burden of HIV disease through the systematic HIV-related research training of investigators and by increasing in-country training capacity. The knowledge gained from this effort will improve public health by informing health care providers and policymakers about best practices in the management of persons living with HIV infection.","1890872; ","DEHOVITZ, JACK A;","BANSAL, GEETHA PARTHASARATHY","06/01/2017","04/30/2022","Academy; Address; Applications Grants; Award; base; Caring; Central Asia; certificate program; Collaborations; Conflict (Psychology); Country; Development; Eastern Europe; Educational Curriculum; Elements; Epidemic; Epidemiology; Faculty; faculty mentor; Goals; Health Care Sector; HIV; implementation science; injection drug use; institutional capacity; International; Link; Measures; Mentorship; New York; Nongovernmental Organizations; programs; Public Health Education; Public Health Schools; Recording of previous events; Research; Research Methodology; Research Support; Research Training; Russia; Statistical Data Interpretation; Students; Surveys; Training; Training Programs; Training Support; Ukraine; USSR; ","Ukraine HIV Research Training Program","010562","ZRG1","Special Emphasis Panel ","","","04","283905","14661","298566",""
"9976784","R21","HD","1","N","05/22/2020","05/22/2020","04/30/2021","865","R21HD099380","SCHOOLS OF NURSING","PA-18-482","1R21HD099380-01A1","NICHD:234000\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","COLUMBUS","UNITED STATES","NONE","03","832127323","US","6218701","OHIO STATE UNIVERSITY","OH","432101016","Narrative Excessive gestational weight gain frequently occurs in overweight or obese pregnant women. It increases pregnant women?s risk for gestational diabetes, gestational hypertension, cesarean delivery and giving birth to an overly large baby. The proposed self-directed, web-based intervention aims to prevent excessive gestational weight gain in overweight or obese pregnant women by promoting stress management, healthy eating and physical activity.","8024122; ","CHANG, MEI-WEI ;","MIODOVNIK, MENACHEM","05/22/2020","04/30/2022","37 weeks gestation; actigraphy; Address; Affect; Attention; Behavior; Behavior Therapy; Behavioral; Birth; Body Weight; Brain region; Cellular Phone; Cesarean section; Clinic; clinical practice; Cognition; cost; Data; design; Diet; Eating; Electronic Health Record; emotion regulation; Emotions; Energy Metabolism; Enrollment; Event; executive function; Fatty acid glycerol esters; Feedback; Fetal Macrosomia; Fostering; fruits and vegetables; Future; Gestational Diabetes; gestational weight gain; Goals; Health; Healthy Eating; healthy lifestyle; High birth weight infant; Hour; Imagination; improved; Individual; innovation; Intake; Internet; Intervention; intervention effect; intervention participants; Intervention Studies; Life; Life Style; Location; Measurement; Measures; Medical center; Minority; Motivation; Obesity; obesity in children; Ohio; Online Systems; Outcome; Overweight; Participant; Persons; Physical activity; postpartum weight; Pregnancy; pregnancy hypertension; pregnant; Pregnant Women; Prenatal care; prevent; Prevention; primary outcome; Psyche structure; Randomized; Randomized Controlled Trials; recruit; Risk; secondary outcome; Self Efficacy; Self-Direction; Stress; stress management; stress reduction; Surveys; Testing; Thinking; Time; treatment as usual; Treatment Efficacy; Universities; Visualization; Walking; weight maintenance; Weight maintenance regimen; Woman; ","Using mental imagination to prevent excessive gestational weight gain in overweight and obese pregnant women","099380","PRDP","Psychosocial Risk and Disease Prevention Study Section ","","A1","01","150000","84000","234000",""
"10167304","U19","AI","3","N","05/19/2020","05/19/2020","07/31/2020","","U19AI128913","","PA-18-591","3U19AI128913-03S2","NIAID:89137\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","1867400 (contact); 7748143; ","REED, ELAINE F (contact); SARWAL, MINNIE M;","ROBIEN, MARK ANDREW","05/19/2020","07/31/2021","","Core-003","128913","","","9130","S2","03","57139","31998","","89137"
"9921432","P30","EY","5","N","05/20/2020","04/01/2020","03/31/2021","","P30EY008098","","PAR-17-322","5P30EY008098-32","NEI:247014\","RESEARCH CENTERS","2020","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","","11426441; ","SIGAL, IAN A;","","","","base; Biological Assay; Caring; Core Grant; Data; data acquisition; Data Analyses; Data Collection; data integrity; Data Storage and Retrieval; Development; Equipment; Ethical Analysis; Ethics; experience; Experimental Designs; Faculty; Fluorescence; Funding; Goals; Image; Image Analysis; imaging modality; Knowledge; Laboratories; Methodology; Methods; Microscopy; Optical Coherence Tomography; Phase; Protocols documentation; Research Personnel; Research Project Grants; success; Technical Expertise; theories; Training; Vision; Vision research; ","Image Acquisition and Analysis Core","008098","ZEY1","Special Emphasis Panel ","5949","","32","157836","89178","","247014"
"9938147","S10","OD","1","N","05/18/2020","05/18/2020","05/17/2021","351","S10OD027038","","PAR-19-179","1S10OD027038-01A1","OD:600000\","OTHER RESEARCH-RELATED","2020","OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH","","HOUSTON","UNITED STATES","","09","800772139","US","578407","UNIVERSITY OF TX MD ANDERSON CAN CTR","TX","770304009","Project Narrative:  High-precision functional imaging of the lungs allows scientists and physicians to better understand the pathophysiological processes of pulmonary injury and disease. The Polarean® 9820 129Xe hyperpolarizer system enables researchers the ability to conduct HP 129Xe gas MRI of the lungs of both humans and small animals, which provides unparalleled capabilities for probing pulmonary dysfunction. Specifically, at MD Anderson Cancer Center, this system will provide scientists with a means to investigate the pathophysiology of lung pathologies in vivo, which will provide a deeper understanding of the cause and progression of lung injury and disease, as well as provide a superior means to diagnose and stage pulmonary disease and quantify response to therapy.","7614471; ","BANKSON, JAMES A;","HORSKA, ALENA","05/18/2020","05/17/2021","animal imaging; Animal Model; Animals; Applied Research; Basic Science; Cancer Center; Cancer Center Support Grant; cancer therapy; clinical practice; Communities; Ensure; Environmental air flow; Equipment; Functional disorder; Functional Imaging; Funding; Future; Gases; Goals; high resolution imaging; Home environment; Human; human disease; human model; Human Resources; imaging facilities; improved outcome; Injury; Institution; Interdisciplinary Study; Laboratories; Lung; Lung diseases; lung imaging; lung injury; Magnetic Resonance; Magnetic Resonance Imaging; Malignant neoplasm of lung; Malignant Neoplasms; Medical center; member; morphometry; Mus; Patients; Principal Investigator; Quality of life; ranpirnase; Rattus; Research; research facility; Research Personnel; Research Project Grants; Resources; Respiratory physiology; System; Technology; Texas; tool; Translational Research; Translations; United States National Institutes of Health; University of Texas M D Anderson Cancer Center; ","Mark-III 129Xe Gas Polarizer System","027038","ZRG1","Special Emphasis Panel ","","A1","01","600000","","600000",""
"10085517","R01","HL","7","N","05/22/2020","05/22/2020","03/31/2021","837","R01HL141612","SCHOOLS OF MEDICINE","PA-16-160","7R01HL141612-03","NHLBI:325920\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CHICAGO","UNITED STATES","SURGERY","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","Project Narrative For vascular bypass and vascular access procedures, preventing anastomotic stenosis and stricture is the key to improving long-term surgical outcomes and prognosis of patients. We propose to test novel drug-eluting sutures that can release drug right at the site of anastomosis to prevent stenosis and stricture. Our novel electrospinning platform allows us to produce drug-eluting sutures composed of standard surgical sutures wrapped in a biodegradable, nanofiber coating, as well as fully absorbable twisted nanofiber sutures. If successful, these sutures may serve as a platform technology for preventing stenosis in any type of organ anastomosis.","12112655; ","HIBINO, NARUTOSHI ;","LEE, ALBERT","04/01/2018","03/31/2023","Adopted; Anastomosis - action; Animal Model; Animals; antiproliferative drugs; appropriate dose; Arteries; biodegradable polymer; biomaterial compatibility; Blood Cell Count; Blood Vessels; Body Weight; Bypass; Caliber; Cardiovascular Diseases; Cardiovascular Surgical Procedures; Characteristics; Childhood; controlled release; Coronary; Devices; dosage; Dose; drug efficacy; Drug Formulations; drug release kinetics; Electrospinning; Engineering; Ensure; Formulation; Functional disorder; Gel; Gold; graft failure; Growth; healing; Hemodialysis; Human; Hyperplasia; improved; In Vitro; Incidence; Inflammation; Kidney; Lipids; liver function; Longevity; manufacturing process; Metabolic; Methods; migration; Modeling; Morbidity - disease rate; Morphology; nanofiber; novel; novel therapeutics; Nylons; Obstruction; Operative Surgical Procedures; Organ; Organ Transplantation; outcome forecast; Patients; Peripheral; Pharmaceutical Preparations; Physiologic arteriovenous anastomosis; Polymers; Polypropylenes; prevent; Procedures; Process; Prosthesis; Rattus; reconstruction; repaired; restenosis; Sheep; side effect; Sirolimus; Site; Smooth Muscle Myocytes; Spleen; Stenosis; Stents; surgery outcome; Surgical sutures; Technology; Tensile Strength; Testing; Therapeutic; Thinness; Time; Transplantation; Vascular Graft; Vascular Smooth Muscle; Veins; Venous; Wool; ","Novel drug-eluting sutures to prevent vascular graft anastomosis stenosis","141612","BMBI","Biomaterials and Biointerfaces Study Section ","","","03","250000","75920","325920",""
"10131532","U01","DK","3","N","05/21/2020","02/01/2020","01/31/2021","847","U01DK056992","","RFA-DK-15-501","3U01DK056992-21S1","NIDDK:115000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","PROVIDENCE","UNITED STATES","","01","063902704","US","5369401","MIRIAM HOSPITAL","RI","029062853","PUBLIC HEALTH RELEVANCE: Weight loss is recommended for overweight and obese individuals with type 2 diabetes, but the long-term effects of such approaches on the issues of greatest concern to older individuals --including mortality, health care utilization and costs, diabetic complications, quality of life, and frailty -- remain untested. The Look AHEAD-Extension will follow approximately 3800 of these individuals for an additional 4.5 years to determine whether random assignment to an intensive lifestyle intervention focused on weight loss achieved through healthy eating and increased physical activity relative to a control group leads to improved long-term health in later life. This extended follow-up will provide important information about the long-term beneficial effects of a lifestyle intervention in a growing segment of the population-namely those who are older, overweight or obese, and have type 2 diabetes.","1884416; ","WING, RENA R;","KUCZMARSKI, ROBERT J","09/30/1999","01/31/2021","Address; adult obesity; Age; Age-Years; Aging; Ancillary Study; Biochemical; Body Weight decreased; Bone Density; Cardiovascular Diseases; Caring; Clinic Visits; Clinical; Clinical Trials; cohort; comorbidity; Complications of Diabetes Mellitus; Control Groups; cost; cost effective; Data; Data Analyses; Diabetes Mellitus; diabetic; Dimensions; Disease; Education; Elderly; Event; Face; Fatty acid glycerol esters; follow-up; frailty; functional disability; Genetic; Goals; group intervention; Guidelines; Health; Health Care Costs; health care service utilization; Healthcare; healthy aging; Healthy Eating; improved; Incidence; Independent Living; Individual; Infrastructure; Intervention; Kidney Diseases; Lead; Life; lifestyle intervention; Long-Term Effects; Longevity; Measures; medical complication; Microvascular Dysfunction; middle age; mortality; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; outcome prediction; Overweight; Participant; Pathway interactions; Patient-Focused Outcomes; Persons; Phase; Physical activity; Physical Function; Population; post intervention; primary outcome; Process; programs; Public Health; public health relevance; Publications; Quality of life; Randomized; Randomized Controlled Clinical Trials; randomized trial; Recording of previous events; Reporting; Research Project Grants; research study; resilience; secondary outcome; Subgroup; Telephone; Testing; Thinness; trial comparing; Uncontrolled Study; Weight; Weight Gain; ","12/16 Action for Health in Diabetes Extension Study Research Project","056992","ZDK1","Special Emphasis Panel ","","S1","21","78767","36233","115000",""
"9971823","R01","AI","3","N","05/21/2020","04/01/2020","03/31/2021","855","R01AI123422","SCHOOLS OF PUBLIC HEALTH","PA-19-056","3R01AI123422-04S1","NIAID:155563\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BALTIMORE","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","PROJECT NARRATIVE This collaboration between Johns Hopkins University (Drs. Sack, Sears & Debes), the University of Virginia (Drs. Houpt, Liu), a research organization in Tanzania, Kilimanjaro Christian Medical Center (KCMC), (Drs. Mmbanga and Ayesiga) and parent R01 research organization in Cameroon, Meilleur Accès aux Soins de Santé (M.A.Sante) (Dr. Ateudjieu) will characterize the microbiome associations of CRC in Tanzania and their potential linkage to diarrheal diseases in Tanzania and Cameroon. The pro:anti-carcinogenic balance of colon bacteria will be probed to determine if these biomarkers and/or other microbiome features may be useful for early detection and/or prevention of CRC in Africa.","1966424; ","SACK, DAVID A;","HALL, ROBERT H","04/01/2017","03/31/2021","Address; Africa; African; Age; Age of Onset; American Cancer Society; Bacteria; bacterial community; Bacterial Genes; Bacteroides fragilis; Biological Markers; Biopsy Specimen; burden of illness; Cameroon; Cancer Center; Cancer Etiology; carcinogenicity; Cardiovascular Diseases; Cell Proliferation; Cessation of life; Chemopreventive Agent; Cholera; Clinical; Collaborations; Colon; colon bacteria; colon cancer patients; colon carcinogenesis; Colon Carcinoma; colon microbiome; colon microbiota; Colonic Neoplasms; Colonoscopy; Colorectal Cancer; colorectal cancer prevention; colorectal cancer progression; colorectal cancer screening; Communicable Diseases; Communities; cost; cost effective; Country; Data; design; Detection; Developing Countries; Development; Diabetes Mellitus; Diarrhea; diarrheal disease; Disease; E-Cadherin; Early Diagnosis; early onset; Ecology; Ecosystem; Elements; Enteral; Epidemiology; Equilibrium; Escherichia coli; Excision; experience; Feces; Fluorescent in Situ Hybridization; Formalin; Frequencies; frontier; Funding; Fusobacterium nucleatum; Genomic approach; Geography; germ free condition; Germ-Free; Health; Heart Diseases; Human; improved; Incidence; Individual; insight; interest; Interleukin-6; Link; low and middle-income countries; low income country; Malignant Neoplasms; Maternal and Child Health; Medical center; medical schools; men; Metadata; Metagenomics; Methods; microbial; Microbial Biofilms; microbial community; Microbiology; microbiome; microbiota; Molecular; Molecular Epidemiology; Morbidity - disease rate; mortality; mouse model; mucosal biofilms; Mucous Membrane; novel; Parasites; Parents; Pathogenesis; Patients; Pilot Projects; Polyps; Population; population based; potential biomarker; Prevalence; Prevention; Prevention strategy; prospective; Public Health; Publishing; Reporting; Research; Resources; Role; rRNA Genes; screening; Screening for cancer; Shotguns; Site; Specimen; structural biology; surveillance study; Tanzania; Techniques; Testing; Time; trend; United States; United States National Institutes of Health; Universities; Virginia; Virus; Woman; World Health Organization; ","Epidemiology and Ecology of Cholera in Africa","123422","IRAP","Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section ","","S1","04","95000","60563","155563",""
"9924652","P20","NR","5","N","05/22/2020","05/01/2020","04/30/2021","","P20NR016599","","RFA-NR-16-001","5P20NR016599-05","NINR:111362\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","HADLEY","UNITED STATES","","02","153926712","US","850904","UNIVERSITY OF MASSACHUSETTS AMHERST","MA","010359450","","8115068; ","JACELON, CYNTHIA S;","","","","Activities of Daily Living; Acute; Adult; Affect; Arthritis; base; Beds; Behavior; Boston; Cellular Phone; Chronic; Chronic Disease; Clinical; Clinical Sciences; Communities; Computer Analysis; Computers; Congestive Heart Failure; cost; design; Development; Drug Prescriptions; Educational workshop; Engineering; Exercise; experience; Family; Fatigue; Feedback; Fibromyalgia; Fostering; functional status; Funding; Goals; Grant; handheld equipment; Health; health care service; Healthcare; Home Care Services; Human; improved; Individual; Industry; Infrastructure; innovative technologies; International; Intervention; Intervention Studies; Lead; Length of Stay; Malignant Neoplasms; Massachusetts; Medical center; medical schools; meetings; Mentors; mindfulness; Monitor; multidisciplinary; multiple chronic conditions; Multiple Sclerosis; new technology; Nurses; Obstructive Sleep Apnea; Office Visits; Onset of illness; persistent symptom; Physiological; Pilot Projects; Postpoliomyelitis Syndrome; prevent; Productivity; program dissemination; psychologic; Publications; Quality of life; Reporting; Research; Resources; Scientist; Secure; sensor technology; Sleep disturbances; Stroke; symptom management; symptom science; symptom self management; symptomatic improvement; Symptoms; System; Tablets; Technology; Testing; Time; Translational Research; Universities; wearable sensor technology; Wireless Technology; Workplace; ","UManage Admin-Core","016599","ZNR1","Special Emphasis Panel ","5300","","05","88779","54121","","111362"
"9933894","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:226384\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1880061; ","NISWENDER, KEVIN D;","","","","Abbreviations; Address; Animals; Award; bariatric surgery; Bioinformatics; Biological Assay; Biological Models; Canis familiaris; Capital; Catheters; Clinical and Translational Science Awards; Closure by clamp; Complex; design; Development; Diabetes Mellitus; Digestive System Disorders; embryonic stem cell; energy balance; experience; Experimental Designs; experimental study; farmer; flexibility; Funding; Gastrectomy; Gastric Bypass; Genetic; genetic resource; genetic variant; Gluconeogenesis; Glucose; Grant; Hormones; Human; Human Genetics; Human Resources; human subject; Human Volunteers; Image; in vivo; in vivo Model; Infrastructure; Institutes; Insulin; Measurement; Measures; Metabolic; metabolic phenotype; Metabolism; Methodology; Methods; mouse model; Mus; Operative Surgical Procedures; Organism; Performance; Personnel Staffing; Philosophy; Physiology; Polishes; pre-clinical; Procedures; Process; Protocols documentation; Rattus; Research; Research Personnel; Research Training; Resource Sharing; Resources; Rodent; scale up; Scientist; Services; stable isotope; Structure; Training; Translations; Work; Zebrafish; ","Metabolic Physiology Shared Resource","020593","ZDK1","Special Emphasis Panel ","7647","","43","159795","66589","","226384"
"9906232","P01","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P01GM095467","","PAR-13-280","5P01GM095467-10","NIGMS:74726\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","","1887763; ","SERHAN, CHARLES NICHOLAS;","","","","Acute; Advisory Committees; Area; Basic Science; Bioinformatics; career; CD59 Antigen; Clinical; Communication; Communities; cost effective; Data; Data Analyses; data sharing; Development Plans; Disease; Equilibrium; Expenditure; experience; experimental study; Floor; Fostering; Goals; graduate student; Health; Home Page; Hospitals; Human; Human Resources; improved; Individual; Infection; Inflammation; insight; Institute of Medicine (U.S.); Institution; Internet; Letters; Link; Manuscripts; Mediator of activation protein; medical schools; meetings; member; Mission; Monitor; multidisciplinary; National Institute of General Medical Sciences; operation; Pathway interactions; Pharmacology; Postdoctoral Fellow; Preparation; programs; Progress Reports; Protocols documentation; Reagent; Research; Research Personnel; Resolution; Resources; Role; Schedule; Services; Site; Supervision; symposium; synergism; Translations; United States National Institutes of Health; Update; Validation; Woman; Work; ","Advisory and Communications Core A","095467","ZGM1","Special Emphasis Panel ","6578","","10","45689","29037","","74726"
"9868866","P01","AG","5","N","05/18/2020","03/01/2020","02/28/2021","","P01AG009524","","PAR-13-258","5P01AG009524-25","NIA:165212\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","TAMPA","UNITED STATES","","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","PUBLIC HEALTH RELEVANCE NARRATIVE- Core-002 Presbycusis, or Age -Related Hearing Loss (ARHL), is the number one communication disorder and number one neurodegenerative condition of our expanding aging population; and comprises one of the top 3 chronic medical conditions, along with arthritis and cardiovascular diseases. The vast majority of people over age 60 are affected by this progressive decline in auditory sensitivity and speech understanding, which are hallmarks of ARHL. Despite this high prevalence of ARHL, there currently are no medical treatments for preventing or reversing permanent hearing loss (ARHL or other types). The thematic focus of this proposal is modulation of presbycusis through biotherapeutics and acoustic treatments. If the experiments proposed here to test hypotheses concerning interventions to modulate the progression of presbycusis are successful, the novel results should lead to clinical trials of the efficacy of these innovative technological, acoustic and drug-related treatments.","10191757; ","DING, BO ;","","","","Acoustics; Affect; Age; age related; aged; Aging; aging auditory system; aging brain; aging population; Aldosterone; Ammonium Chloride; Anatomy; Animal Experiments; Animals; Arthritis; Auditory; auditory processing; base; behavior measurement; Biological; Biological Assay; Biological Markers; Biological Response Modifier Therapy; Blood; Blood Chemical Analysis; Blood Pressure; Brain; brain circuitry; brain tissue; Cardiovascular Diseases; Cellular biology; Chronic; Clinical; Clinical Trials; Collaborations; Communication impairment; Complement; Complex; Data Analyses; Dissection; drug discovery; efficacy trial; Environment; Enzyme-Linked Immunosorbent Assay; Etiology; experimental study; Exposure to; follow-up; Future; Gene Expression; Goals; Hearing; High Pressure Liquid Chromatography; High Prevalence; Histologic; Hormonal; Hormones; Image Analysis; Immune; immunocytochemistry; improved; In Situ Hybridization; Inbred CBA Mice; indexing; innovation; Intervention; Investigation; Knowledge; Lead; Longitudinal Studies; Measurement; Medical; Modification; Molecular; Molecular Biology; multidisciplinary; Mus; Nerve Degeneration; Neural Pathways; neuropathology; novel; Outcome Measure; Pathway interactions; Perfusion; Peripheral; permanent hearing loss; Pharmaceutical Preparations; Physiological; Presbycusis; prevent; Procedures; Production; Progress Reports; protein expression; Proteomics; public health relevance; Publications; Rattus; relating to nervous system; Reporting; Research; Rodent; Science; Serum; Services; Severities; sound; Speech; Standardization; Structure; Sum; Supplementation; System; Systems Biology; Techniques; Testing; Therapeutic Intervention; Time; tissue processing; Tissues; Translational Research; Western Blotting; ","Structure and Function Services Core","009524","ZAG1","Special Emphasis Panel ","5992","","25","110807","54405","","165212"
"9974889","R21","HG","1","N","05/18/2020","05/18/2020","04/30/2021","172","R21HG011120","SCHOOLS OF MEDICINE","RFA-HG-18-002","1R21HG011120-01","NHGRI:234000\","Non-SBIR/STTR RPGs","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","PHILADELPHIA","UNITED STATES","BIOCHEMISTRY","03","053284659","US","4050801","THOMAS JEFFERSON UNIVERSITY","PA","191074418","Project Narrative  We aim to explore 3Dpol as an RNA-dependent RNA polymerase in direct and real-time sequencing of RNA. As a processive polymerase across long and highly structured RNA, with electronic protein conductance that is sensitive to NTP-binding, 3Dpol is uniquely suited as an enzymatic reader of RNA. If this potential of 3Dpol is fully developed, we envision that direct RNA-seq by the polymerase can be realized in the clinic with real-time feedback.","1862335; ","HOU, YA-MING ;","SMITH, MICHAEL","05/18/2020","04/30/2023","Address; Arizona; base; Base Sequence; Binding; Biological Sciences; Clinic; clinical practice; Complement; Complementary DNA; Complementary RNA; Complex; conformational conversion; Crystallization; Data; Decision Making; Development; Devices; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerase; Double-Stranded RNA; Dyes; electric field; Electrodes; Electronics; Engineering; epigenomics; experimental study; Feedback; Gene Expression; Generations; Genetic Transcription; Genome; Genomics; High-Throughput Nucleotide Sequencing; Human Genome; Human poliovirus; improved; Individual; Ions; Label; Masks; Measurement; Measures; Methods; Modification; Monitor; nanopore; novel; novel sequencing technology; Nucleic Acids; nucleobase; Nucleotides; Polymerase; Process; Property; Proteins; Reader; Reading; Reporting; Reproducibility; Research; Resolution; response; RNA; RNA chemical synthesis; RNA Sequences; RNA-Directed DNA Polymerase; RNA-Directed RNA Polymerase; Scanning Probe Microscopes; sequencing platform; Signal Transduction; Signaling Protein; single molecule; solid state; Stretching; Structure; Technology; Testing; Therapeutic; Third Generation Sequencing; Time; tool; transcriptome sequencing; Variant; Viral Proteins; viral RNA; Virus Replication; Work; ","Exploring 3Dpol for RNA sequencing in real time","011120","ZHG1","Special Emphasis Panel ","","","01","150000","84000","234000",""
"9997415","R01","DK","1","N","05/21/2020","05/21/2020","04/30/2021","847","R01DK124097","SCHOOLS OF MEDICINE","PA-19-056","1R01DK124097-01A1","NIDDK:739547\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NEW YORK","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","13","078861598","US","3839801","ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI","NY","100296574","Current treatment options for obesity are limited, have a modest impact, and are typically short-lived. Traditionally, research has focused on obese individuals and on the mechanisms that cause weight gain. Here, we propose a paradigm shift and aim to provide new targets for treatment and prevention by studying the mechanisms that prevent weight gain in normal weight individuals with a high genetic predisposition to obesity.","11307605; ","LOOS, RUTH JF;","KARP, ROBERT W","05/21/2020","04/30/2024","Alleles; Animal Model; Behavior; biobank; Body Weight; Brain; Calorimetry; Characteristics; Chronic Disease; Data; Desire for food; doubly-labeled water; Eating; Energy Intake; Energy Metabolism; Exercise stress test; exome; Functional Magnetic Resonance Imaging; Funding; General Population; Genes; Genetic; Genetic Predisposition to Disease; Genetic study; Genome; genome wide association study; Genotype; Human; Hunger; Hypothalamic structure; Individual; induced pluripotent stem cell; insight; interest; LEPR gene; Leptin; Life Style; loss of function; Metabolism; microbiome analysis; Monitor; Mutation; mutation carrier; Neurons; Non obese; non-genetic; Nonsense Mutation; Obesity; obesogenic; Outcome; Overweight; Participant; Pathway interactions; Patients; Penetrance; Phenotype; phenotypic data; Physiology; Population; Positioning Attribute; prevent; Prevention; programs; recruit; Regulation; Reporting; Research; resilience; Rewards; Risk Factors; Satiation; severe early onset obesity; SH2B gene; Signal Transduction; Testing; Time; Trans-Omics for Precision Medicine; Variant; Weight; Weight Gain; Work; ","Resilience to obesity in carriers of monogenic obesity mutations - a study on the underlying mechanisms","124097","ZRG1","Special Emphasis Panel ","","A1","01","498333","241214","739547",""
"10073138","R01","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R01AI148648","","PA-19-056","1R01AI148648-01A1","NIAID:847913\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Blockade of the T cell inhibitory receptor PD-1 has revolutionized cancer therapy and is now explored for treatment of chronic viral infection, another condition marked by exhausted immunity. In this project we will evaluate whether and how PD-1 blockade enhances immunity to hepatitis B virus (HBV) in an HBV PD-1 blockade trial. The expected results will dramatically increase our understanding of the molecular response to PD-1 blockade and thus will enable further refinement of these groundbreaking new therapies.","1936402; 7117365 (contact); ","CHUNG, RAYMOND T; LAUER, GEORG MICHAEL (contact);","KOSHY, RAJEN","05/22/2020","04/30/2025","Advanced Malignant Neoplasm; Affect; AIDS clinical trial group; Antigen Targeting; antigen-specific T cells; Antigens; Antitumor Response; Antiviral Agents; Blood; cancer therapy; CD8-Positive T-Lymphocytes; CD8B1 gene; Cell Nucleus; Cells; Cellular Immunity; Cessation of life; checkpoint therapy; Chronic; Chronic Hepatitis B; chronic infection; Clinical Trials; Data; design; digital; Disease; Epigenetic Process; exhaust; exhaustion; Fine needle aspiration biopsy; Freezing; Funding; Genetic Transcription; Genomics; global health; Hepatitis B Vaccines; Hepatitis B Virus; Hepatocyte; HIV; Human; Immune; immune checkpoint blockade; Immune response; Immune system; Immunity; Immunologics; Immunotherapeutic agent; Immunotherapy; In Situ; Individual; Inflammatory; Innate Immune Response; insight; intrahepatic; laser capture microdissection; Liver; macrophage; Mediating; Mediator of activation protein; Minority; Molecular; monocyte; National Institute of Allergy and Infectious Disease; Natural Immunity; novel; novel therapeutics; Participant; pathogen; Pathway interactions; Patients; PD-1 blockade; PD-1 pathway; Peripheral Blood Mononuclear Cell; Persons; pgRNA; Phagocytes; Phenotype; Population; Population Heterogeneity; programmed cell death ligand 1; programmed cell death protein 1; receptor; Recovery; Regulation; response; Sampling; Structure of molecular layer of cerebellar cortex; T cell response; T-Lymphocyte; Testing; Therapeutic; Tissues; Transcriptional Regulation; Treatment Failure; Treatment outcome; Viral; Viral Antigens; Viral Cancer; viral RNA; Virus; Virus Diseases; Virus Replication; ","Immunologic correlates of functional cure of HBV with immune checkpoint blockade","148648","ZRG1","Special Emphasis Panel ","","A1","01","508000","339913","847913",""
"10142952","U19","AI","3","N","05/19/2020","05/19/2020","03/31/2021","855","U19AI057229","SCHOOLS OF MEDICINE","PA-18-591","3U19AI057229-17S1","NIAID:640459\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","STANFORD","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943052004","PROJECT NARRATIVE COVID-19, caused by SARS-CoV-2, is now a worldwide pandemic and requires urgent and swift attention to develop efficacious therapeutics. Here we propose to use cutting-edge technologies developed in the Davis and Mak labs to comprehensively map viral epitopes and identify T cell targets critical for protection. Work here will directly inform ongoing vaccine development efforts and will be critical in halting the spread and mortality due to this virus.","1884203; ","DAVIS, MARK MORRIS;","JIANG, CHAO","05/19/2020","03/31/2022","2019-nCoV; Affect; antiviral immunity; Attention; Blood specimen; Cancer Center; CD8-Positive T-Lymphocytes; China; Country; COVID-19; Development; Disease; Epidemic; Epitope Mapping; Epitopes; experience; Haplotypes; Hong Kong; Infection; Influenza; Maps; Mediating; Middle East Respiratory Syndrome Coronavirus; mortality; Organoids; pandemic disease; Patients; Persons; response; RNA Viruses; SARS coronavirus; Specificity; success; Survivors; T cell response; T-Cell Immunologic Specificity; T-Lymphocyte; Technology; Therapeutic; Tonsil; tool; Travel; Vaccination; vaccine development; Vaccines; Viral; Virus; Work; World Health Organization; ","Influenza responses and repertoire in vaccination, infection and tonsil organoids.","057229","ZAI1","Special Emphasis Panel ","","S1","17","456251","184208","640459",""
"10116650","R01","DE","7","N","05/21/2020","04/15/2020","06/30/2021","121","R01DE026471","SCHOOLS OF MEDICINE","PA-18-590","7R01DE026471-04","NIDCR:305000\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH","","Chicago","UNITED STATES","PHARMACOLOGY","07","098987217","US","577703","UNIVERSITY OF ILLINOIS AT CHICAGO","IL","606124305","RELEVANCE Although the overall incidence of head and neck cancer has decreased steadily in the past decades, the number of reported oropharyngeal cancer cases has increased significantly. The long-term goal of this research is to develop clinical prognostic assays for individualized oropharyngeal cancer treatment by focusing on microRNAs, which are a class of small non-coding RNAs that play important regulatory roles in tumorigenesis.","8280466; ","WANG, XIAOWEI ;","WANG, CHIAYENG","04/15/2020","06/30/2023","","MICRORNA BIOMARKERS FOR OROPHARYNGEAL CANCER","026471","CBSS","Cancer Biomarkers Study Section ","","","04","200000","105000","305000",""
"10167305","U19","AI","3","N","05/19/2020","05/19/2020","07/31/2020","","U19AI128913","","PA-18-591","3U19AI128913-03S2","NIAID:77994\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","1867400 (contact); 7748143; ","REED, ELAINE F (contact); SARWAL, MINNIE M;","ROBIEN, MARK ANDREW","05/19/2020","07/31/2021","","Core-004","128913","","","9131","S2","03","49996","27998","","77994"
"9899740","T32","CA","5","N","05/22/2020","04/01/2020","03/31/2021","398","T32CA009172","","PA-16-152","5T32CA009172-45","NCI:789722\","TRAINING, INSTITUTIONAL","2020","NATIONAL CANCER INSTITUTE","","BOSTON","UNITED STATES","","07","076580745","US","1464901","DANA-FARBER CANCER INST","MA","022155450","Narrative  The overall objective of this Training Program is to prepare the next generation of leaders in Medical Oncology in laboratory and clinical translational sciences. The program will provide outstanding mentored laboratory and clinical investigation research experiences from senior and experienced junior faculty and support for the recruitment and mentorship of under-represented minority fellows. It is expected that at the conclusion of their training, those individuals supported by this training program will have the ability to design, initiate, and complete individual clinical or laboratory research projects, will be able to function independently or with minimal supervision, and will be positioned to soon establish themselves as independent research investigators.","1941096; ","DECAPRIO, JAMES A;","SCHMIDT, MICHAEL K","07/01/1980","03/31/2022","anticancer research; Training; ","Graduate Training in Cancer Research","009172","NCI","Subcommittee I - Transistion to Independence ","","","45","731224","58498","789722",""
"9918915","R01","DK","5","N","05/20/2020","05/01/2020","04/30/2021","847","R01DK113504","","PA-16-188","5R01DK113504-05","NIDDK:396261\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","WASHINGTON","UNITED STATES","","98","143983562","US","1518602","CHILDREN'S RESEARCH INSTITUTE","DC","200102916","Painful bladder syndromes affect up to 40% of some patient populations and effective therapies do not exist for many of these people. We propose to exploit a parasite-derived protein, IPSE, as a candidate therapeutic due to its ability to modulate host immune and non-immune responses to bladder injury. We hypothesize that IPSE can be optimized for therapeutic potential (while minimizing toxicity) through the generation of mutant forms with altered ability to modulate host responses via three distinct mechanisms: IL-4-binding, chemokine-binding, and nuclear localization.","9958935; ","HSIEH, MICHAEL HARRISON;","BAVENDAM, TAMARA G","05/05/2017","04/30/2022","Adverse reactions; Affect; Apoptosis; Basophils; Behavior; Binding; Biology; Bladder; Bladder Diseases; Bladder Injury; bladder pain; CCL2 gene; CCL3 gene; Cell Adhesion; Cell Nucleus; Cells; chemokine; Chinese Hamster Ovary Cell; Chronic; Cystitis; cytokine; Data; Dendritic Cells; Disease model; Dose; effective therapy; egg; Engineering; Enteral; Epithelial Cells; Freezing; Functional disorder; gastrointestinal; Generations; Genes; Genetic Transcription; Genitourinary system; Hemorrhage; Homologous Gene; Hypersensitivity; Ifosfamide; IgE; IL8 gene; Immune; Immune response; in silico; Incidence; Increased frequency of micturition; ineffective therapies; Interleukin-4; Interstitial Cystitis; intestinal epithelium; Intravenous; intravesical; Lead; Ligands; Link; Malignant neoplasm of urinary bladder; mast cell; Mesna; Modeling; mouse model; Mus; mutant; Nerve; Nitric Oxide Synthase; novel therapeutics; Nuclear; Nuclear Localization Signal; Nuclear Translocation; Oncogenes; Overactive Bladder; Pain; pain behavior; pain receptor; Parasites; Pathway interactions; patient population; Patients; Peripheral; Production; Property; Proteins; RANTES; Recombinants; Resiniferatoxin; Rodent; Rodent Model; Role; Schistosoma haematobium; Schistosoma mansoni; side effect; Spinal Ganglia; spontaneous pain; standard of care; Symptoms; Syndrome; Testing; Therapeutic; therapeutic candidate; Therapeutic Effect; Toxic effect; TRPV1 gene; Ulcer; Uropathogen; Urothelial Cell; Variant; Viral; Work; ","Therapeutic Exploitation of IPSE, a Urogenital Parasite-Derived Host Modulatory Protein, for Bladder Hypersensitivity Syndromes","113504","ZRG1","Special Emphasis Panel ","","","05","225000","171261","396261",""
"9930083","R01","DK","5","N","05/20/2020","05/01/2020","04/30/2021","847","R01DK117481","EARTH SCIENCES/RESOURCES","PAS-16-033","5R01DK117481-03","NIDDK:427075\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BERKELEY","UNITED STATES","NUTRITION","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947101749","Project Narrative This project details a study that will elucidate how mitochondrial stress leads to the functional decline of hematopoietic stem cells during aging. This study will have profound implications in drug development for preventing bone marrow failure, improving injury repair, and preventing diseases of hematopoietic stem cell origin.","8876418; ","CHEN, DANICA ;","BISHOP, TERRY ROGERS","05/01/2018","04/30/2022","2 year old; Address; Adult; Age; age related; aged; Aging; Animals; Biochemical; biological adaptation to stress; Blood; CASP1 gene; Cell Aging; Cell Death; Cell Maintenance; Cell physiology; Clinic; Collection; Data; Deacetylase; Deterioration; Disease; DNA Damage; drug development; Event; functional decline; Functional disorder; gain of function; genetic manipulation; Hematopoiesis; hematopoietic stem cell fate; Hematopoietic Stem Cell Research; Hematopoietic stem cells; Hematopoietic System; improved; Incidence; Inflammasome; injury and repair; Knock-out; Knockout Mice; Lead; leukemia; Life; Maintenance; Mitochondria; Molecular; Molecular Target; mouse model; Myelogenous; nicotinamide-beta-riboside; novel; Pancytopenia; Pathway interactions; Physiological; prevent; Process; programs; Regulatory Pathway; Role; self-renewal; Signal Pathway; Signal Transduction; Sirtuins; stem cell biology; Stress; System; Testing; Therapeutic; ","Hematopoietic Stem Cell Aging","117481","ASG","Aging Systems and Geriatrics Study Section ","","","03","272022","155053","427075",""
"9927560","UC7","AI","5","N","05/19/2020","05/01/2020","04/30/2021","855","UC7AI094660","SCHOOLS OF MEDICINE","RFA-AI-15-009","5UC7AI094660-10","NIAID:11500000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","GALVESTON","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","14","800771149","US","578406","UNIVERSITY OF TEXAS MED BR GALVESTON","TX","775555302","PUBLIC HEALTH RELEVANCE    Project Narrative National Biocontainment Laboratories Operational Support ensures the availability of maximum containment laboratories for research that will develop the next generation of therapeutics, diagnostics and vaccines for infectious diseases that can pose a public health risk. It also ensures that high containment labs are available in the event of a public health or bioterrorism emergency. This support is essential due to the high cost of building and maintaining laboratories that protect researchers, ensure the biosecurity of dangerous pathogens, and safeguard the communities where these laboratories are located.            Admin-Core-001 - Administrative Core","10363552; ","LEDUC, JAMES W.;","BOYD, NANCY G","05/31/2011","04/30/2021","biodefense; biosecurity; Bioterrorism; Communicable Diseases; Communities; Containment; cost; Dangerousness; Diagnostic; Emergency Situation; Ensure; Environmental Health; Event; Funding; Goals; Infrastructure; Laboratories; Laboratory Research; Maintenance; Medical; National Institute of Allergy and Infectious Disease; novel therapeutics; operation; pathogen; pre-clinical; Public Health; public health emergency; public health relevance; Regulation; Research; research facility; Research Personnel; Resources; Risk; Services; Texas; Universities; Vaccines; ","Limited Competition: National Biocontainment Laboratories (NBLs) Operations Support (UC7)","094660","ZAI1","Special Emphasis Panel ","","","10","7786165","3713835","11500000",""
"10146615","R01","AI","3","N","05/22/2020","05/22/2020","07/31/2020","855","R01AI134236","SCHOOLS OF MEDICINE","PA-18-591","3R01AI134236-03S1","NIAID:117308\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAINT LOUIS","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","01","068552207","US","9083901","WASHINGTON UNIVERSITY","MO","631304862","Narrative COVID-19 has emerged as a major pandemic leading to widespread morbidity and mortality. Innate lymphoid cells in the lung may provide protection against viral pathogens including SARS-CoV-2. As part of this R01 proposal, we have established unique BSL-3 containment single cell technologies to study innate responses in the lung against tuberculosis. In this supplement, we will utilize these unique BSL-3 capabilities for single cell technologies to analyze lung samples from a recently developed macaque model of SARS-Cov-2 infection and determine the role of innate cells in protection and pathogenesis of COVID-19.","7360179; 8802018 (contact); ","COLONNA, MARCO ; KHADER, SHABAANA A. (contact);","JIANG, CHAO","05/22/2020","07/31/2022","","The Role of Group 3 Innate Lymphoid cells (ILC3) in Tuberculosis","134236","ZRG1","Special Emphasis Panel ","","S1","03","74481","42827","117308",""
"10160488","R35","GM","3","N","05/21/2020","09/01/2019","08/31/2020","859","R35GM128675","SCHOOLS OF MEDICINE","PAR-17-190","3R35GM128675-02S1","NIGMS:12026\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","VALHALLA","UNITED STATES","ANATOMY/CELL BIOLOGY","17","041907486","US","5948901","NEW YORK MEDICAL COLLEGE","NY","105951524","PROJECT NARRATIVE Our proposal focuses on investigating the molecular mechanism by which Estrogen Receptor cooperates with the mechanistic target of rapamycin (mTOR) signaling in regulating cellular processes in homeostasis and disease. Specifically, we would determine how estrogen activates mTOR, and what downstream processes are subsequently affected.","10183528; ","HOLZ, MARINA K;","KODURI, SAILAJA","09/01/2018","08/31/2023","Affect; base; Biochemical; Cell physiology; Cells; Cellular biology; Coupled; Data; Disease; Estrogen Receptors; estrogenic; Estrogens; Event; FRAP1 gene; Goals; Growth; Homeostasis; interest; Investigation; Mediating; Molecular; Normal Cell; Pathway interactions; phosphoproteomics; polysome profiling; Process; programs; Protein Biosynthesis; Proteins; Proteomics; Publishing; Research; Role; Signal Pathway; Signal Transduction; stem; Transcriptional Regulation; transcriptome sequencing; Work; ","Estrogenic signaling upstream and downstream of mTOR","128675","ZGM1","Special Emphasis Panel ","","S1","02","7333","4693","12026",""
"9903224","R01","CA","5","N","05/20/2020","05/01/2020","04/30/2021","393","R01CA163915","SCHOOLS OF MEDICINE","PA-13-302","5R01CA163915-09","NCI:377649\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","STANFORD","UNITED STATES","PATHOLOGY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943052004","NARRATIVE Human genetic studies over the past 5 years revealed that mutations in the mSWI/SNF or BAF complex contribute to about 20% of human cancers. We will define the molecular mechanism by which the BAF or mSWI/SNF complex suppresses the emergence of cancer in humans and explore the possibility that small molecules binding to these complexes could be useful in treatment of specific kinds of cancer.","1891587; ","CRABTREE, GERALD R.;","WITKIN, KEREN L","07/10/2012","04/30/2022","Amino Acids; ATPase Domain; base; Binding; Biological; Biological Assay; cancer cell; Characteristics; Chromatin; chromatin remodeling; combinatorial; Complex; Dependence; design; Development; early screening; exome sequencing; Gene Deletion; Genes; Genetic Recombination; Genetic study; Genetic Transcription; Genome; Grant; Human; Human Genetics; in vivo; inhibitor/antagonist; Investigation; Kinetics; Laboratories; Malignant Neoplasms; Mediating; Missense Mutation; Molecular; Mutation; Nature; Normal Cell; novel; Oncogenic; Pattern; Pharmaceutical Preparations; Play; Polycomb; PRC1 Protein; Production; Proteins; Recurrence; repaired; Repression; Role; small molecule; Specificity; Surface; System; Techniques; Therapeutic; tool; tumor; Tumor Suppressor Proteins; tumorigenesis; Work; ","ATP-Dependent Chromatin Remodeling in Human Malignancy","163915","CG","Cancer Genetics Study Section ","","","09","237500","140149","377649",""
"9907247","R43","HL","1","N","05/20/2020","05/20/2020","04/30/2021","837","R43HL150917","","PA-18-574","1R43HL150917-01","NHLBI:791543\","SBIR-STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","SAN DIEGO","UNITED STATES","","52","830062803","US","10021734","VENTRIX, INC.","CA","921095754","Project Narrative The development of therapies to treat myocardial infarction is a necessity because of the large patient population that declines into heart failure. This proposal seeks to perform initial pre-clinical studies to translate a novel catheter deliverable biomaterial therapy for treating acute myocardial infarction.","6766164; 9846988 (contact); ","CHRISTMAN, KAREN L; KINSEY, ADAM M (contact);","LUNDBERG, MARTHA","05/20/2020","04/30/2021","Acute; Acute myocardial infarction; American; Animals; Apoptosis; Arrhythmia; Balloon Angioplasty; Balloon Occlusion; Biocompatible Materials; Cardiac Myocytes; Cardiomyopathies; Catheters; Cause of Death; Cell Therapy; Cells; clinically relevant; cost; Data; Development; Echocardiography; Environment; Extracellular Matrix; Family suidae; Fibrosis; Formulation; Gel; Geometry; Germ Cells; Guidelines; Heart; Heart failure; heart function; Heart Transplantation; Histology; Holter Electrocardiography; Hydrogels; Immunohistochemistry; improved; Infarction; inflammatory milieu; Infusion procedures; Injectable; Injections; Intervention; ischemic cardiomyopathy; Left; left ventricular assist device; Meta-Analysis; Metabolism; minimally invasive; Modeling; Myocardial; Myocardial Infarction; Myocardium; neovascularization; new technology; novel; novel therapeutics; Organ; particle; Particulate; patient population; Patients; Phase; Phase I Clinical Trials; Phase II Clinical Trials; Pre-Clinical Model; preclinical study; Rattus; Recording of previous events; Recurrence; regenerative; Regenerative Medicine; repaired; Safety; Small Business Innovation Research Grant; standard of care; statistics; submicron; success; Testing; therapy development; Therapy trial; Tissue Engineering; Tissues; Translating; United States National Institutes of Health; Ventricular; ","New infusible ECM hydrogel for treating acute myocardial infarction","150917","ZRG1","Special Emphasis Panel ","","","01","","","791543",""
"9913377","U01","AI","5","N","05/20/2020","04/01/2020","03/31/2021","855","U01AI138334","","RFA-AI-17-001","5U01AI138334-03","OD:462874\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAN FRANCISCO","UNITED STATES","","12","080199257","US","10043351","OSSIUM HEALTH, INC.","CA","941023916","NARRATIVE Bone marrow transplants could be life-saving procedures for victims of accidental radiation exposure or nuclear attack. The procedure is commonly used to treat blood cancers; however, there are significant risks. Largely because of these risks, bone marrow transplant is not recommended for victims of accidental or intentional (i.e, terrorist attack) radiation exposure. Certain stem cells have been shown in patients to reduce risks associated with transplants and facilitate recovery. Ossium Health is developing a novel stem cell, termed OssioStem-M3, that has shown promise in bone marrow transplant patients. We propose to develop OssioStem for treating radiation victims.","6160295; ","WOODS, ERIK J.;","RIOS, CARMEN I","04/19/2018","03/31/2023","Acute Graft Versus Host Disease; Address; Affect; Allogenic; analog; animal rule; Aplastic Anemia; Aspirate substance; Autologous; Biological Process; Body Weight; bone; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Cadaver; Cell Count; cell injury; Cells; Characteristics; Clinical Data; Clinical Research; Clinical Trials; Colony-Forming Units Assay; Complication; cost effective; Cryopreservation; Data; Devices; Digestion; disorder prevention; Dose; Effectiveness; efficacy study; Engraftment; Exposure to; Failure; Family suidae; gastrointestinal; gastrointestinal system; Goals; graft failure; graft vs host disease; Harvest; Head; Health; Hematopoietic; Hematopoietic Cell Production; Hematopoietic Neoplasms; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Hematopoietic System; Immune Cell Suppression; Immune response; Immune system; immunoregulation; Incidence; Industrial Accidents; Infusion procedures; innovation; Ionizing radiation; irradiation; Licensure; Life; Liver; Living Donors; long bone; Medical; Medicine; Mesenchymal; Methods; Miniature Swine; Modeling; mouse model; Mus; next generation; novel; Nuclear; Nuclear Warfare; Occupational Accidents; Organ; Organ Donor; Pathology; Patients; Peptide Hydrolases; peripheral blood; Phenotype; pre-clinical; prevent; Procedures; Process; product development; Production; programs; Property; Protocols documentation; Radiation; Radiation exposure; Radiation Toxicity; reconstitution; Recovery; Research; rib bone structure; Risk; Safety; Savings; Severities; Skin; soft tissue; Source; Spinal; stem; stem cell therapy; Stem cells; Sternum; Stream; Stromal Cells; success; Supporting Cell; Syndrome; System; Terrorism; Testing; Therapeutic; Time; Tissue Donors; tissue regeneration; Tissues; Transplant Recipients; Transplantation; Validation; vertebra body; ","OssioStem-matched multipotent MSC (M3): banked, low passage bone marrow MSC for treatment of hematopoietic acute radiation syndrome.","138334","ZAI1","Special Emphasis Panel ","","","03","282240","180634","462874",""
"10117918","R01","GM","3","N","05/19/2020","02/01/2020","01/31/2021","859","R01GM126048","SCHOOLS OF ARTS AND SCIENCES","PA-18-906","3R01GM126048-03S1","NIGMS:45543\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","IRVINE","UNITED STATES","ANATOMY/CELL BIOLOGY","45","046705849","US","577504","UNIVERSITY OF CALIFORNIA-IRVINE","CA","926173213","PROJECT NARRATIVE  The Hippo pathway, which is conserved from Drosophila to mammals, has been recognized as a  crucial signaling pathway governing cell proliferation and apoptosis, two key events involved in tissue  homeostasis and organ size control. Although several upstream regulators, conserved kinase cascade, key  downstream effectors and nuclear transcriptional factors have all been identified, the detailed regulatory  mechanisms for the Hippo pathway remain to be elucidated. My proposed research will focus on a new lipid  signaling branch in regulation of the Hippo pathway, which will provide us an opportunity to uncover additional  components/regulators for this putative pathway.    ","11795711; ","WANG, WENQI ;","XU, JIANHUA","02/01/2018","01/31/2023","Actins; Address; Apoptosis; base; Binding; cell growth; Cell Nucleus; Cell Polarity; Cell Proliferation; Complex; Contact Inhibition; Cues; Cytoskeleton; Data; Drosophila genus; Enzymes; Event; extracellular; F-Actin; G Protein-Coupled Receptor Signaling; Gene Silencing; Genetic Transcription; Goals; Growth Factor; Homeostasis; Hormones; Hypoxia; Interleukin-2; Knowledge; LATS1 gene; Lipids; Mammals; Mechanics; Mediating; Mediator of activation protein; Metabolic; Modeling; novel; Nuclear; Nuclear Translocation; Organ; Organ Size; Pathway interactions; Phosphatidic Acid; phospholipase D1; Phospholipids; Phosphorylation; Phosphotransferases; Play; Polymers; Production; protein function; Proteomics; Regulation; Research; Resistance; response; rho; rho GTP-Binding Proteins; Role; Second Messenger Systems; Signal Pathway; Signal Transduction; Stimulus; Stress; Tissues; transcription factor; upstream kinase; ","Lipid signaling in Hippo pathway regulation","126048","","","","S1","03","32988","12555","45543",""
"9932123","F30","HL","5","N","05/18/2020","05/15/2020","05/14/2021","837","F30HL147499","SCHOOLS OF ARTS AND SCIENCES","PA-18-668","5F30HL147499-02","NHLBI:34763\","TRAINING, INDIVIDUAL","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","Boulder","UNITED STATES","CHEMISTRY","02","007431505","US","1199902","UNIVERSITY OF COLORADO","CO","803031058","Project Narrative  This proposal will study how Polycomb Repressive Complex 2 regulates cardiomyocyte specific gene  expression. Findings generated from the proposed aims will expand our understanding of a mechanism that  governs proper heart development, function, and could provide pathways for future cardiomyopathy therapies. ","12361399; ","YOUMANS, DANIEL THOMAS;","MEADOWS, TAWANNA","05/15/2019","05/14/2023","Affect; Affinity; Alleles; alpha Actin; Binding; Biochemistry; Biology; Biotechnology; Cardiac; Cardiac development; Cardiac Myocytes; cardiogenesis; Cardiomyopathies; Cell Lineage; cell type; Cells; Cessation of life; Chromatin; chromatin immunoprecipitation; Colorado; Community Developments; Complex; Computational Biology; Data; Development; Developmental Gene; Diffusion; Dilated Cardiomyopathy; DNA; DNA Binding; DNA Sequence; Doxycycline; Ectopic Expression; Embryonic Development; experimental study; fascinate; Functional disorder; Future; Gene Expression; Gene Expression Regulation; Gene Silencing; Genes; Genetic; Genetic Transcription; Genome; genome editing; Genomics; heart function; Heart Hypertrophy; Heterochromatin; High-Throughput Nucleotide Sequencing; Histone H3; Histones; Human; human pluripotent stem cell; Hypertrophic Cardiomyopathy; Hypertrophy; Image; imaging approach; immunocytochemistry; improved; Individual; Knock-out; Knockout Mice; Lysine; Maintenance; Manuscripts; Mediating; Mentorship; Methods; Modeling; Modification; molecular imaging; multidisciplinary; Mus; mutant; Mutation; Oral; osteosarcoma; Pathway interactions; Phenotype; Physicians; Play; Polycomb; Post-Translational Protein Processing; premature; prevent; programs; promoter; Property; Proteins; Publications; recruit; Research; residence; Role; Scientist; single molecule; Site; Stains; stem cell differentiation; symposium; System; Testing; Time; Training; transcription factor; Transcriptional Regulation; transcriptome sequencing; Troponin T; Universities; Up-Regulation; Ventricular Remodeling; ","Mechanism of PRC2-mediated Gene Silencing during Cardiomyocyte Differentiation","147499","ZRG1","Special Emphasis Panel ","","","02","34763","","34763",""
"9912199","R01","MH","5","N","05/19/2020","04/01/2020","03/31/2021","242","R01MH112758","SCHOOLS OF MEDICINE","PA-16-160","5R01MH112758-03","NIMH:544762\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PITTSBURGH","UNITED STATES","PSYCHIATRY","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","PROJECT NARRATIVE This project seeks to describe the neurobiological processes underlying a core dimensional phenotype of negative emotional experience that cuts across the mood and anxiety disorders. We will examine whether this phenotype is associated with a specific pattern of abnormal brain function during attempts to regulate emotional experience. Findings from this project will help us to identify neurobiological targets that we could use to develop more effective, individually tailored treatments for young people with depression and anxiety. !","9771070; ","FOURNIER, JAY C;","ZALCMAN, STEVEN J","06/01/2018","03/31/2023","Acute; Amygdaloid structure; Anger; Anterior; Anxiety; Anxiety Disorders; anxiety symptoms; base; Brain; brain abnormalities; cingulate cortex; Clinical; cognitive control; Conflict (Psychology); Conscious; Data; Depressive disorder; depressive symptoms; diaries; Dimensions; Distress; Dorsal; emotion regulation; Emotional; emotional experience; Emotions; Ensure; experience; follow up assessment; follow-up; Functional disorder; functional outcomes; Future; Goals; Grain; Hostility; humiliation; Impairment; improved; Individual; individualized medicine; interest; Lead; Measures; Mental Depression; Mental disorders; Modeling; Mood Disorders; National Institute of Mental Health; Nature; negative affect; network dysfunction; neural circuit; neural model; neural patterning; neurobiological mechanism; Neurobiology; neuroimaging; neuroimaging marker; neuromechanism; Neuronal Dysfunction; novel; Occupational; Participant; Pattern; personalized medicine; Phenotype; Prefrontal Cortex; Process; Productivity; prospective; Protocols documentation; Psychiatric Diagnosis; psychiatric symptom; Psychopathology; Public Health; recruit; Regulation; relating to nervous system; Research Domain Criteria; response; Rest; secondary analysis; Severities; Shame; Symptoms; System; Testing; Visit; Work; young adult; ","Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety","112758","NPAS","Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section ","","","03","360371","184391","544762",""
"9927666","R01","HL","5","N","05/23/2020","05/01/2020","04/30/2021","837","R01HL143067","SCHOOLS OF MEDICINE","PA-18-484","5R01HL143067-02","NHLBI:489753\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","HOUSTON","UNITED STATES","GENETICS","09","051113330","US","481201","BAYLOR COLLEGE OF MEDICINE","TX","770303411","Project Narrative Heart failure has a circadian rhythmicity and is associated with a stereotypical gene expression program. We have identified a circadian repressor that suppress the switch to the pathological gene program in the heart. Understanding how the circadian machinery controls gene expression programs in the heart may lead to novel intervention for heart failure.","11974958; ","ZHANG, LILEI ;","TJURMINA, OLGA A","05/08/2019","04/30/2024","Address; Affect; Age; Aging; Agonist; base; Base Pairing; Binding; Binding Sites; Biotin; Cardiac; Cardiac health; Cardiac Myocytes; Cell Nucleus; cell type; Cells; chromatin modification; circadian; Circadian Rhythms; Clinical; Dilated Cardiomyopathy; Disease; DNA; DNA Binding Domain; Enhancers; Exhibits; experimental study; Foundations; gain of function; Gene Expression; Gene Expression Regulation; gene repression; Genes; Genetic; Genetic Transcription; Genome; Goals; Heart; Heart failure; heart function; Heart Hypertrophy; hemodynamics; Human; Hypertrophy; improved; in vivo; Incidence; induced pluripotent stem cell; Intervention; Lead; loss of function; LoxP-flanked allele; Modeling; Molecular; mortality; mouse model; Mus; Muscle Cells; mutant; Neonatal; novel; novel strategies; novel therapeutics; Output; Pathologic; Periodicity; Pharmaceutical Preparations; Pharmacology; Physiological; pressure; prevent; Prevention; programs; Rattus; recruit; Resolution; Rest; Role; Site; Specificity; Stable Disease; stem cell differentiation; Stress; Structure; Swimming; Switch Genes; Testing; Therapeutic; Time; Tissues; tool; transcription factor; Transcriptional Regulation; transcriptomics; Transgenic Organisms; Treatment Failure; Ventricular; young adult; ","Transcriptional regulation of cardiac pathological remodeling by REV-ERB?","143067","CCHF","Cardiac Contractility, Hypertrophy, and Failure Study Section ","","","02","321481","168272","489753",""
"10075697","R01","HL","3","N","05/20/2020","05/20/2020","03/31/2021","837","R01HL141941","BIOMED ENGR/COL ENGR/ENGR STA","PA-18-906","3R01HL141941-03S1","NHLBI:68610\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","COLUMBUS","UNITED STATES","ENGINEERING (ALL TYPES)","03","832127323","US","6218701","OHIO STATE UNIVERSITY","OH","432101016","PROJECT NARRATIVE The initial flow of blood plasma across the vessel wall that may ultimately trigger angiogenesis is regulated by the mechanical junctions between endothelial cells that line blood vessel walls. This research aims to establish a fundamental understanding of the role of endothelial cell interactions and remodeling in mediating the early stage mechanisms that lead to local plasma leakage, which could ultimately provide novel mechanisms for controlling pathological angiogenesis.","11145278; 9639007; 10452976 (contact); ","CASTRO, CARLOS E.; PRAKASH, SHAURYA ; SONG, JONATHAN  (contact);","LEE, ALBERT","04/01/2018","03/31/2022","3-Dimensional; Actins; Address; angiogenesis; Angiogenesis Inhibitors; Architecture; base; Benchmarking; Biophysics; Blood; Blood flow; Blood Vessels; cadherin 5; Cardiovascular Diseases; CD31 Antigens; Cell Communication; Cell Line; Cell membrane; Cells; Characteristics; Confocal Microscopy; Coupled; Data; design; Devices; DNA; DNA Binding; Electron Microscopy; Endothelial Cells; Endothelium; Engineering; experimental study; Extravasation; fluid flow; Fluorescence Resonance Energy Transfer; functional outcomes; Goals; In Vitro; Inflammation; Intercellular Junctions; Knowledge; Lead; Length; Liquid substance; Malignant Neoplasms; Measurement; Measures; Mechanical Stimulation; Mechanical Stress; Mechanics; Mediating; Microfluidics; Microscopy; microsystems; Modeling; Monitor; monolayer; Morphology; nanodevice; nanoscale; novel; Optics; Pathologic Neovascularization; Pathology; Pathway interactions; Pharmacology; Physiological; Plasma; pressure; Proteins; Reporting; Research; Resolution; response; Role; Rupture; sensor; shear stress; Side; Site; solute; Spectrum Analysis; Stress; Structure; System; Techniques; Testing; Therapeutic; Time; Tissues; Vascular Diseases; Vascular Permeabilities; Vascular remodeling; Water; ","Biophysical-based approach for controlling blood vessel structure and function","141941","BMBI","Biomaterials and Biointerfaces Study Section ","","S1","03","49329","19281","68610",""
"9917811","R01","HL","5","N","05/18/2020","05/01/2020","04/30/2021","838","R01HL138473","SCHOOLS OF MEDICINE","PA-16-160","5R01HL138473-04","NHLBI:705629\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","STANFORD","UNITED STATES","PEDIATRICS","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943052004","Pulmonary arterial hypertension is a lethal disease, currently without cure, that arises after the inner lining of blood vessels is injured.  Our proposal evaluates the relationship between a genetic vulnerability causing loss of a protective pathway related to abnormal BMPR2 function, and an environmental stress causing deleterious expansion of two potentially deleterious innate immune factors HERV-K and LTB4. We determine how these factors contribute to the obliteration of lung vessels and to the progression of pulmonary arterial hypertension.  ","8432204; 2413447 (contact); ","NICOLLS, MARK ROBERT; RABINOVITCH, MARLENE  (contact);","XIAO, LEI","07/01/2017","04/30/2021","Anabolism; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Arterial Disorder; Autoimmune Process; Autoimmunity; Biological Models; Biological Response Modifiers; Biology; Blood Vessels; bone loss; bone morphogenetic protein receptors; cell injury; cell transformation; Clinical Trials; Confocal Microscopy; Coupled; cytokine; Data; Development; Disease; Drug Targeting; dUTP pyrophosphatase; Endogenous Retroviruses; Endothelial Cells; Endothelium; endotracheal; Evolution; Exposure to; Flow Cytometry; Functional disorder; Gene Expression; Gene Expression Profile; Genetic; Genetic Predisposition to Disease; Genetic Transcription; Genetic Translation; Genotype; Human; Hypoxia; IL6 gene; Immune; Immunologic Factors; immunotherapy trials; Impairment; Inflammation; Inflammatory; Inflammatory Response; injured; Injury; Intravenous; Knowledge; Laboratories; Lead; Leukotriene B4; Leukotriene Production; Leukotrienes; Link; Lung; macrophage; Macrophage Activation; Maps; Mediating; Mesenchymal; Microfluidics; Modeling; monocyte; Mus; mutant; Natural Immunity; Oxidants; Pathway interactions; Patients; Play; Population; Process; Production; Proteins; pulmonary arterial hypertension; pulmonary artery endothelial cell; Pulmonary Hypertension; Pulmonary Pathology; Rattus; receptor; Recombinants; recruit; Recurrence; Resistance; response; Retroviridae Infections; Rodent Model; Role; Signal Transduction; single-cell RNA sequencing; Stimulus; Stress; success; Testing; Time; TP53 gene; Transferase; Transgenic Organisms; Vascular Diseases; Vascular remodeling; Virus Diseases; Work; ","Endothelial Injury, BMPR2 Dysfunction and Macrophage Activation Cause EndMT and PAH","138473","ZRG1","Special Emphasis Panel ","","","04","573092","132537","705629",""
"10050063","R01","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R01AI148365","SCHOOLS OF VETERINARY MEDICINE","PA-19-056","1R01AI148365-01A1","NIAID:743912\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ATHENS","UNITED STATES","VETERINARY SCIENCES","10","004315578","US","676602","UNIVERSITY OF GEORGIA","GA","306021589","PUBLIC HEALTH RELEVANCE: Pneumocystis jirovecii is the causative agent of Pneumocystis pneumonia (PCP), which remains a life-threatening illness of increasing concern in individuals with weakened immune systems. The research proposed research will further advance a vaccine candidate and immune-therapeutic for the prevention and treatment of PCP in immunocompromised individuals. The successful completion of these studies will advance these vaccine candidate and immunotherapeutics toward clinical trials.","1882082; ","NORRIS, KAREN A;","ZOU, LANLING","05/21/2020","04/30/2025","Acute; Address; Adverse reactions; Aging; Animals; Antibiotics; Antibodies; Antibody titer measurement; antiretroviral therapy; Autoimmune Diseases; Bone Marrow Transplantation; Cancer Patient; Chemotherapy-Oncologic Procedure; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Clinical Trials; clinically relevant; Collagen; Crohn's disease; Data; Defect; Development; Diagnosis; Diagnostic; Disease; experience; Exposure to; Generations; Goals; Guidelines; Hematologic Neoplasms; HIV; Human; Humoral Immunities; Hyperimmunoglobulin M Syndrome; Immune; Immune response; Immune system; Immunity; Immunization; Immunocompromised Host; immunosuppressed; Immunosuppression; Immunosuppressive Agents; Immunotherapeutic agent; Impairment; improved; Incidence; Individual; Infection; Infection Control; Inflammatory; innovation; innovative technologies; insight; Life; Lung; Macaca mulatta; Memory; Modeling; Monkeys; Monoclonal Antibodies; Morbidity - disease rate; mortality; Nature; nonhuman primate; novel therapeutics; Obstructive Lung Diseases; Opportunistic Infections; Organ; Organ Transplantation; Organism; pathogen; pathogenic fungus; patient population; Patients; Persons; Pharmaceutical Preparations; Pneumocystis; Pneumocystis carinii; Pneumocystis carinii Pneumonia; Pneumocystis Infections; Pneumonia; Population; pre-clinical; Pre-Clinical Model; prevent; Prevention; Prevention strategy; Preventive; prophylactic; Prophylactic treatment; Prospective Studies; protective efficacy; Protein Subunits; public health relevance; pulmonary function; Pulmonary Pathology; Recombinant Proteins; Regimen; Reporting; Research; Resolution; Resources; response; Rheumatoid Arthritis; Risk; Role; seropositive; Severe Combined Immunodeficiency; SIV; Solid; Solid Neoplasm; Subunit Vaccines; Testing; Therapeutic; Therapeutic immunosuppression; Therapeutic Uses; Transplant Recipients; Treatment Failure; Trimethoprim-Sulfamethoxazole; vaccine candidate; Vaccines; Vascular Diseases; Virus Diseases; ward; Work; ","Prevention and Treatment of Pneumocystis Pneumonia","148365","VMD","Vaccines Against Microbial Diseases Study Section ","","A1","01","498905","245007","743912",""
"9919642","K01","MH","5","N","05/22/2020","04/01/2020","03/31/2021","242","K01MH117443","SCHOOLS OF MEDICINE","PA-18-369","5K01MH117443-02","NIMH:179426\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","NEW YORK","UNITED STATES","OBSTETRICS & GYNECOLOGY","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","The proposed research is relevant to public health because nearly 40% of children worldwide experience adversities, including physical and sexual abuse, poverty, and parental death, and these adversities may account for nearly a third of adult mental disorders. The research career made possible by this K01 award will help to generate new evidence about maternal childhood adversity and biological and behavioral pathways of intergenerational transmission of mental health risk. This research career will help to inform public health policy and intervention strategies for breaking the cycle of poor mental health and socioeconomic disadvantage.","11841079; ","SCORZA, PAMELA LORRAINE;","BECHTHOLT, ANITA J","04/22/2019","03/31/2023","Address; Adult; adverse childhood events; attentional control; base; Behavior; behavior observation; Behavioral; Behavioral Mechanisms; biobank; biobehavior; Biological; Biological Assay; Blood specimen; Budgets; career; caregiving; Cessation of life; Child; Child Health; Child Mental Health; Child Rearing; Childhood; childhood adversity; cohort; Cohort Studies; Communities; Data; Data Collection; Data Set; Development; Disadvantaged; disadvantaged population; Disease; DNA; DNA Methylation; early childhood; early life stress; epigenetic marker; Epigenetic Process; epigenome; Event; experience; Exposure to; Future; Generations; Genes; genome-wide; genome-wide analysis; Goals; hands-on learning; Health; Health Policy; Human; Individual; Infant; innovation; intergenerational; Intervention; Investigation; Knowledge; Life; Longitudinal Studies; maternal caregiving; Measures; Mental disorders; Mental Health; Mentored Research Scientist Development Award; Mentors; Mentorship; Methylation; Mother-Child Relations; Mothers; National Institute of Mental Health; New York; Newborn Infant; next generation; offspring; Outcome; Parents; Participant; Pathway interactions; Perinatal; peripheral blood; physical abuse; Population; population based; Population Study; Poverty; Pregnancy; Pregnant Women; Prevention Research; Process; programs; prospective; psychobiology; psychologic; Public Health; Puerto Rican; Puerto Rico; Reaction; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; response; Risk; Risk Factors; Sample Size; Sampling; Sexual abuse; Signal Transduction; socioeconomic disadvantage; Stress; stressor; Training; translational approach; transmission process; Umbilical Cord Blood; United Kingdom; United States National Institutes of Health; Vulnerable Populations; Woman; Work; Youth; ","Mothers' childhoods and the intergenerational transmission of mental health risk in the context of adversity","117443","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","","02","166268","13158","179426",""
"9977767","R43","MH","5","N","05/18/2020","05/01/2020","04/30/2021","242","R43MH119906","","PA-18-708","5R43MH119906-02","NIMH:260927\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","SOUTH SAN FRANCISCO","UNITED STATES","","14","169610016","US","10000058","BIODESY, INC","CA","940806102","Narrative A biophysical tool for the on-target study of G protein coupled receptors (GPCRs) that reports on structural, and in turn functional, outcomes of ligand binding to these important drug targets is in demand. The goal of the proposed project is to solve this problem by developing a high-throughput, Second Harmonic Generation (SHG)-based, commercial screening platform for use in both identifying new chemical matter and characterizing known ligands that directly modulate the structure and function of GPCRs.","15540631 (contact); 11944509; ","MOREE, BEN  (contact); O'MALLEY, MICHELLE ANN;","GRABB, MARGARET C","05/10/2019","04/30/2021","ADORA2A gene; Affinity; Animal Model; assay development; Avidin; base; Binding; Biochemical; Biological; Biological Assay; biophysical tools; Biophysics; Biotin; Brain; C-terminal; Cells; Chemicals; Chimeric Proteins; Collection; Consumption; Coupling; Cysteine; Data; design; Detergents; Development; Devices; Docking; drug discovery; Drug Targeting; Dyes; Equipment; Exhibits; Family member; flexibility; functional outcomes; G-Protein-Coupled Receptors; Generations; Goals; GTP-Binding Proteins; high throughput analysis; high throughput screening; in silico; interest; Label; Length; Libraries; Ligand Binding; Ligands; Liquid substance; Lysine; Measures; Membrane Proteins; Mental disorders; Methods; Miniaturization; Modeling; Mutagenesis; Neurotensin Receptors; novel; Optics; Peptide antibodies; Phenotype; Play; Point Mutation; Problem Solving; Process; programs; Proteins; prototype; Reading; receptor; Reporting; Resistance; Resolution; response; Role; Running; Sampling; screening; second harmonic; Signal Transduction; small molecule; small molecule libraries; Specificity; Structure; structured data; Surface; Tail; Technology; Testing; Time; Validation; Work; X-Ray Crystallography; Yeasts; ","SHG based screening assay for detecting effectors of brain localized GPCRs that can be used to probe mental illness related phenotypes","119906","ZRG1","Special Emphasis Panel ","","","02","","","260927",""
"10126188","K23","MH","7","N","05/20/2020","05/12/2020","12/31/2021","242","K23MH119331","","PA-18-590","7K23MH119331-02","NIMH:156166\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","NEW YORK","UNITED STATES","","13","167204994","US","1590919","NEW YORK STATE PSYCHIATRIC INSTITUTE","NY","100321007","PROJECT NARRATIVE The proposed research will be accomplished through a research-practice partnership. It will develop an innova- tive service delivery model by adapting an evidence-based health communication strategy for educational set- tings and applying this new method to improve access and continuity of care for children with autism spectrum disorder (ASD) in diverse communities. This work will strengthen the public health impact of NIMH-supported research.","15393142; ","AZAD, GAZI FERDOUSI ;","HILL, LAUREN D","01/01/2020","12/31/2024","Address; Adherence; Area; autism spectrum disorder; autistic children; Award; Baltimore; base; Behavior; Behavioral; career; career development; Child; Cities; Communication; Communication Barriers; communication theory; Communities; Complement; Complex; Consultations; Continuity of Patient Care; Control Groups; Data Collection; Distal; Doctor of Philosophy; dosage; early childhood; Education; Elements; Ensure; evidence base; Evidence based practice; Evidence based program; experimental group; Feedback; Focus Groups; Funding; Goals; Health; Health Communication; Home environment; Impairment; Improve Access; improved; innovation; Institutes; Intervention; Interview; Knowledge; Link; Literature; Measures; Mental Health Services; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modeling; multidisciplinary; National Institute of Mental Health; National Research Service Awards; Nursery Schools; Online Systems; Outcome; Parents; Partnership Practice; patient oriented research; Patients; Physicians; Problem Solving; psychoeducational; Public Health; Qualitative Methods; Randomized; Regulation; Research; Research Personnel; Research Support; Sampling; satisfaction; Schedule; school health; Schools; Self Efficacy; Service delivery model; shared decision making; skills; skills training; Students; Surveys; System; teacher; Testing; Training; Translating; treatment planning; Universities; Visual; webinar; Work; ","Partners in School: Promoting Continuity across Home and School for Children with Autism by Improving Parent-Teacher Communication during the Transition to School","119331","SERV","Mental Health Services Research Committee ","","","02","144598","11568","156166",""
"9922333","R01","HL","5","N","05/18/2020","05/01/2020","04/30/2021","837","R01HL114822","","PA-16-160","5R01HL114822-08","NHLBI:396588\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CAMBRIDGE","UNITED STATES","","05","054552435","US","1589901","NATIONAL BUREAU OF ECONOMIC RESEARCH","MA","021385359","OTHER PROJECT INFORMATION ? Project Narrative The recent proliferation of life-saving cardiac technologies such as percutaneous coronary intervention (PCI) tends to concentrate among affluent communities, often resulting in poorer access to these facilities in low-income communities. By providing direct evidence of how changes in PCI access affect health outcomes of patients with AMI and stable CAD in different communities, this research will inform policymakers about the implications of PCI proliferation and closures at the community, hospital, and individual level.","9676886; 8614007 (contact); ","HSIA, RENEE YUEN-JAN; SHEN, YU-CHU  (contact);","FINE, LARRY","08/17/2012","04/30/2021","Address; Affect; American; American Hospital Association; Area; Automobile Driving; base; beneficiary; Cardiac; care delivery; Caring; Censuses; Characteristics; Code; cohort; Communities; Community Hospitals; Community Surveys; Control Groups; Coronary Arteriosclerosis; County; Data; Data Sources; Databases; Diffusion; experience; Goals; Health; Health Care Costs; Healthcare; Healthcare Market; Hospitals; improved; improved outcome; Individual; individual patient; information organization; Information Systems; Investments; Lead; Life; Light; Link; Location; Low income; Medicaid; Medical; Medicare; Medicare claim; Minority; neighborhood safety; Outcome; Pathway interactions; Patient-Focused Outcomes; Patients; Pattern; percutaneous coronary intervention; Population; population health; Procedures; Provider; Reporting; Research; Resource Allocation; Resources; Rural; safety net; Savings; Site; Surveys; System; Technology; Testing; Time; Ursidae Family; Vulnerable Populations; wasting; ","Effects of Percutaneous Coronary Intervention Lab Openings and Closures on Patients, Hospitals, and Communities","114822","HSOD","Health Services Organization and Delivery Study Section ","","","08","330690","65898","396588",""
"10145110","P30","CA","3","N","05/21/2020","01/01/2020","12/31/2020","","P30CA015704","","PAR-17-095","3P30CA015704-45S2","NCI:249999\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","SEATTLE","UNITED STATES","","07","078200995","US","861001","FRED HUTCHINSON CANCER RESEARCH CENTER","WA","981094433","Not applicable to P30 CCSG as stated in the FOA PAR-17-095.","1862283; ","LAW, WENDY ;","HE, MIN","","","Administrator; anticancer research; Area; Attention; Cancer Center; Cancer Center Support Grant; career; Catchment Area; Clinical Trials; Collaborations; Communities; Community Outreach; Data; design; Development; Ensure; Evaluation; Faculty; Feedback; Funding; Goals; Grant; Guidelines; Heart; improved; Infrastructure; innovation; Institution; Interdisciplinary Study; Intervention Trial; Journals; Leadership; Maintenance; Malignant Neoplasms; Measures; meetings; member; Mind; Monitor; mouse model; operation; Philanthropic Fund; pre-clinical; Process; programs; Publications; ranpirnase; Recommendation; Research; Research Support; Resource Allocation; Resource Sharing; Resources; Science; Secure; Strategic Planning; success; symposium; Training and Education; tumor; Universities; Vision; Washington; Work; ","Cancer Center Administration","015704","NCI","Subcommittee I - Transistion to Independence ","7829","S2","45","142045","107954","","249999"
"9995569","R01","HL","5","N","05/21/2020","05/01/2020","04/30/2021","838","R01HL148152","SCHOOLS OF PUBLIC HEALTH","PA-18-484","5R01HL148152-02","NHLBI:557405\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","149617367","US","3212904","HARVARD SCHOOL OF PUBLIC HEALTH","MA","021156028","Project Narrative To migrate, it is widely presumed that the epithelial cell must first go through an epithelial-to-mesenchymal transition (EMT) or, more commonly, a partial EMT; this proposal argues, however, that our discovery of the cellular unjamming transition (UJT) reveals a powerful, unifying, and overriding biological principle that is distinct from the EMT mechanism but potentially is no less important. If true, we will have reframed a core concept in epithelial cell biology. Impact potentially spans development biology, wound repair, asthmatic airway remodeling, and metastatic disease.","1887476 (contact); 10337610; ","FREDBERG, JEFFREY J (contact); PARK, JIN-AH ;","POSTOW, LISA","08/15/2019","04/30/2023","Adherens Junction; Air; airway remodeling; Appearance; asthmatic; asthmatic airway; attenuation; Back; Behavior; Biological; Biology; body cavity; bronchial epithelium; Carcinoma; Cell Line; cell motility; Cells; Cellular biology; combinatorial; Complement; Data; design; Development; Diffusion; Disease; Duct (organ) structure; E-Cadherin; Electrical Resistance; Embryonic Development; Epithelial; Epithelial Cells; epithelial to mesenchymal transition; Epithelium; Event; Fingerprint; fluorescein isothiocyanate dextran; Foundations; Gatekeeping; Growth; Health; Human; immune function; Intervention; Lead; Liquid substance; Literature; Malignant Neoplasms; Maps; Measures; Mechanics; Mesenchymal; migration; Molecular; Molecular Structure; Morphogenesis; Multicellular Process; multiple omics; N-Cadherin; Neoplasm Metastasis; novel; Organ; PARD6A gene; Permeability; Phenotype; Physics; Physiological; Physiological Processes; Process; programs; protein biomarkers; protein protein interaction; repaired; Route; slug; Structure; Surface; Testing; Tight Junctions; transcription factor; Transitional Epithelium; Vimentin; Wound Healing; ","Physics of bronchial epithelial unjamming","148152","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","","02","349470","207935","557405",""
"10130995","R01","HL","3","N","05/20/2020","05/18/2020","06/30/2020","838","R01HL136143","SCHOOLS OF MEDICINE","PA-16-160","3R01HL136143-03S1","NHLBI:427924\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PITTSBURGH","UNITED STATES","INTERNAL MEDICINE/MEDICINE","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","Project Narrative: Acute lung injury, or acute respiratory distress syndrome (ARDS) is characterized by persistent neutrophilic inflammation and is the final common pathway of a variety of direct and indirect insults to the lungs. Lower respiratory tract bacterial infections and pneumonia contribute to prolonged respiratory failure, and increase morbidity and mortality in patients with ARDS. The broad, long term objective is to identify key factors that promote host protection against pathogen-triggered lung injury.","6579067; ","LEE, JANET S.;","ZHOU, GUOFEI","05/18/2020","06/30/2021","Acute; Acute Lung Injury; Acute Pneumonia; Adult Respiratory Distress Syndrome; Aggressive behavior; Alpha Granule; Alveolar; Anti-inflammatory; Bacterial Infections; Bacterial Pneumonia; base; Biological Assay; Blood Circulation; Blood Platelets; Blood Vessels; Bone Marrow Transplantation; Cathepsin G; Cells; Clinical; combat; Complication; cytokine; Cytoplasmic Granules; Data; day length; Development; Elastases; Endothelium; Exhibits; extracellular; Extracellular Matrix; Failure; Future; Glycoproteins; Gram-Negative Bacteria; Hematopoietic; Hemostatic function; Host Defense; Immune; Immune response; Immunity; Impairment; In Vitro; in vivo; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; inhibitor/antagonist; Injury; Interleukin-10; Knock-out; Knowledge; Lead; Length of Stay; Leukocyte Elastase; Lower respiratory tract structure; Lung; Lung infections; Lung Inflammation; lung injury; macrophage; Mediating; Metalloproteases; Modeling; Morbidity - disease rate; mortality; mouse model; MPL gene; Mus; neutrophil; Neutrophil Activation; novel; pathogen; Pathway interactions; Patients; Peptide Hydrolases; Platelet Count measurement; Pneumonia; pneumonia model; prevent; Proteins; Proteolysis; Pseudomonas; Pseudomonas aeruginosa; Pseudomonas aeruginosa infection; Recovery; repaired; resilience; Resolution; respiratory; Respiratory Failure; Risk Factors; RNA Interference; Role; screening; Sepsis; Serine Protease; Signal Transduction; Source; Sterility; Testing; Thrombospondin 1; tissue injury; Tissues; Type II Secretion System Pathway; Ventilator; Virulence Factors; ","Mechanisms of host protection against pathogen-secreted proteases in acute lung injury","136143","ZRG1","Special Emphasis Panel ","","S1","03","274517","153407","427924",""
"9923689","R21","HG","5","N","05/19/2020","05/01/2020","04/30/2021","172","R21HG010165","SCHOOLS OF MEDICINE","PA-18-489","5R21HG010165-02","NHGRI:205308\","Non-SBIR/STTR RPGs","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","NEW YORK","UNITED STATES","PEDIATRICS","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","PROJECT NARRATIVE We will develop novel genomic and bioinformatics methods to map how DNA is replicated in the human genome in different cells or different diseases. These methods will help us better understand patterns of DNA replication and genetic stability, ultimately yielding insights into cell proliferation in development, cancer and other diseases.","14183064 (contact); 9361675; ","EGLI, DIETER MEINRAD (contact); WANG, KAI ;","SEN, SHURJO KUMAR","05/01/2019","04/30/2021","Address; Affect; Aging; Asians; ATAC-seq; base; Bioinformatics; Biological Phenomena; Biological Process; Bromodeoxyuridine; Cell Proliferation; cell type; Cells; Cellular biology; ChIP-seq; Communities; computational pipelines; Computer software; Computing Methodologies; cost effective; Cultured Cells; Custom; Data; deep neural network; Detection; Development; Disease; DNA; DNA analysis; DNA biosynthesis; DNA Markers; DNA Modification Process; DNA replication fork; DNA Replication Timing; DNA Sequence; DNA sequencing; DNA-Directed DNA Polymerase; Drops; electrical property; epigenomics; experience; Family; Genetic; Genome; genome integrity; genome-wide; genome-wide analysis; Genomics; Goals; Human; Human Genome; Immunoprecipitation; insertion/deletion mutation; insight; Knowledge; Link; Location; Malignant Neoplasms; Maps; Measures; Methodology; Methods; Modeling; Modification; Names; nanopore; new technology; novel; novel strategies; nucleotide analog; Nucleotides; Optics; Pattern; Phase; Physiologic pulse; Positioning Attribute; Price; Protocols documentation; Publishing; Replication Initiation; Reproducibility; Resolution; Resources; sequencing platform; Series; Signal Transduction; single molecule; stem cell differentiation; Technology; Testing; Time; Tissues; tumor progression; ","Novel approaches to map DNA replication traffic in a genome-wide scale","010165","GCAT","Genomics, Computational Biology and Technology Study Section ","","","02","161150","44158","205308",""
"10038761","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI153683","SCHOOLS OF MEDICINE","PA-19-053","1R21AI153683-01","NIAID:231750\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","IOWA CITY","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","02","062761671","US","3972901","UNIVERSITY OF IOWA","IA","522421320","Virus proteins accomplish virus assembly by making critical interactions with each other. Identifying and characterizing those interactions represents a promising avenue for development of viral therapies and vaccines. This proposal presents a novel system for identifying and characterizing these critical interactions in herpes simplex virus infection.","1903199; ","ROLLER, RICHARD J;","BEISEL, CHRISTOPHER E","05/22/2020","04/30/2022","Animal Model; Apical; Bacterial Artificial Chromosomes; base; Biology; Capsid; Capsid Proteins; Cell Culture Techniques; Cell Line; Cell membrane; Cell Nucleus; Cells; Cytomegalovirus; Cytoplasm; Data; Development; Docking; Dynein ATPase; Endocytosis; Epithelial Cells; Event; Fibroblasts; Glycoproteins; Herpesviridae; Herpesvirus 1; Human; Infection; insight; Integration Host Factors; Kinesin; Maintenance; Membrane; Microtubules; Minus End of the Microtubule; Modeling; Morphogenesis; Motor; Mus; Mutagenesis; Nature; Neurons; novel; Pathway interactions; Production; protein function; Proteins; recruit; Retrieval; Simplexvirus; Site; Source; Structure; System; Testing; Transmembrane Transport; Vaccines; Vesicle; Viral; Viral Genes; Viral Physiology; Viral Proteins; Virion; Virus Assembly; Virus Diseases; ","Characterization of the herpes simplex virus cytoplasmic assembly center in neuronal cells","153683","VIRA","Virology - A Study Section ","","","01","150000","81750","231750",""
"9930460","P01","GM","5","N","05/20/2020","05/01/2020","04/30/2021","","P01GM099134","","PAR-13-280","5P01GM099134-09","NIGMS:439364\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","6746193; ","ZARET, KENNETH ;","","","","Animals; base; Binding; cell type; Cells; Chromatin; Code; Complex; Data; data curation; design; Development; Disease model; Epigenetic Process; Euchromatin; Fibroblasts; Future; Genes; Genetic; Genome Mappings; Genomics; Germ Layers; Goals; Heterochromatin; Histones; Human; Impairment; in vitro Assay; in vitro testing; in vivo; induced pluripotent stem cell; inhibitor/antagonist; interest; knock-down; Maps; Methods; Mus; Mutagenesis; Play; pluripotency; protein function; Proteins; Proteomics; reconstitution; RNA; RNA Processing; Role; Set protein; Somatic Cell; Teratoma; Testing; Therapeutic; transcription factor; X Inactivation; ","Overcoming Barriers to Pluripotency Reprogramming","099134","ZRG1","Special Emphasis Panel ","6049","","09","439364","0","","439364"
"10065844","F30","DC","1","N","05/15/2020","05/16/2020","05/15/2021","173","F30DC018450","SCHOOLS OF MEDICINE","PA-19-191","1F30DC018450-01A1","NIDCD:41270\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS","","BOSTON","UNITED STATES","NONE","07","039318308","US","8422704","TUFTS UNIVERSITY BOSTON","MA","021111901","Project Narrative Successful completion of these aims will elucidate the impact that the Notch ligand, Dll1, has on the functional and molecular identity of horizontal basal cells (HBCs) prior to and during olfactory epithelium (OE) regeneration. Given the Notch signaling pathway's inherent complexities and the diversity of Notch receptors and ligands expressed within the OE, defining the role that Dll1 plays in specifying HBC activity will allow us to more deftly manipulate the only signaling pathway currently known to regulate HBC status both molecularly and functionally. This, in turn, will contribute foundational knowledge to the development of a treatment that therapeutically activates persistently dormant HBCs found in pathologically deteriorated and aneuronal human OE to controllably reverse age-related hyposmia.","14149674; ","LOUIE, JONATHAN DANIEL;","RIVERA-RENTAS, ALBERTO L","05/16/2020","05/15/2024","Age; age related; aged; American; attenuation; Basal Cell; Binding; career; Cell Culture Techniques; cell type; Clinical Treatment; Communication; Data; Demographic Aging; design; Development; Developmental Biology; effective therapy; epithelial injury; exhaust; experience; Failure; Fellowship; Flow Cytometry; Fluorescence-Activated Cell Sorting; Foundations; functional decline; functional status; Genetic Transcription; Grant; Hour; Human; hyposmia; Impairment; In Vitro; in vivo; interdisciplinary approach; knock-down; Knock-out; Knowledge; Laboratories; Lesion; Ligands; Mediating; Medical; Mission; Modeling; Molecular; Morphogenesis; mouse model; Mus; National Institute on Deafness and Other Communication Disorders; Natural regeneration; notch protein; Notch Signaling Pathway; novel; Nutritional status; Olfactory Epithelial Cell; Olfactory Epithelium; olfactory sensory neurons; Output; overexpression; Pathologic; Pathway interactions; Physicians; Play; premature; prevent; Principal Investigator; Quality of life; receptor; Resolution; Role; Safety; Scientist; Sensory; Signal Pathway; Signal Transduction; Smell Perception; Specific qualifier value; stem; stem cell biology; stem cell population; sustentacular cell; Testing; Therapeutic; Tissues; Training; transcription factor; Up-Regulation; Viral; ","The Role of Dll1 in Specifying the Molecular and Functional Status of Horizontal Basal Cells","018450","ZDC1","Special Emphasis Panel ","","A1","01","41270","","41270",""
"9864299","R01","ES","1","N","05/18/2020","05/19/2020","02/28/2021","113","R01ES031080","SCHOOLS OF ARTS AND SCIENCES","PA-19-056","1R01ES031080-01","NIEHS:465692\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","CAMDEN","UNITED STATES","BIOLOGY","01","625216556","US","1196202","RUTGERS THE STATE UNIV OF NJ CAMDEN","NJ","081021405","PROJECT NARRATIVE Hepatotoxicity is a leading safety concern in the development of new chemicals. We will create virtual ?Adverse Outcome Pathway? models that will directly evaluate the hepatotoxicity potentials of chemicals using massive public toxicity data. The primary deliverable of this project will be a publically-accessible, web-based search engine to evaluate new chemicals for risk of hepatotoxicity.","10409713; ","ZHU, HAO ;","RAVICHANDRAN, LINGAMANAIDU V, PHD","05/19/2020","02/28/2025","Address; adverse outcome; Animal Model; Animal Testing; Antioxidants; base; Big Data; Biochemical; Biological; Biological Assay; Biological Markers; candidate validation; cell injury; Cellular Stress; Chemical Injury; Chemical Structure; Chemicals; Clinical; combat; Complement; Complex; computational toxicology; computer framework; Computer Models; Computer software; computerized tools; Computers; cost; Cryopreservation; Custom; Data; data mining; Data Set; Data Sources; Databases; deep neural network; design; Development; developmental toxicity; Drug Costs; drug development; endoplasmic reticulum stress; Ensure; Environment; Environmental Pollution; Evaluation; experimental study; Face; Generations; hepatocellular injury; Hepatocyte; Hepatotoxicity; Human; improved; In Vitro; in vitro Assay; in vitro testing; in vivo; Industrialization; Injury; interest; Internet; knowledge base; large datasets; Libraries; Liver; liver injury; Luciferases; Machine Learning; Marketing; Meta-Analysis; Methodology; Methods; Mining; Modeling; next generation; novel; Nutraceutical; Online Systems; Pathway interactions; Pharmaceutical Preparations; Pharmacologic Substance; Population; pre-clinical; predictive modeling; Process; Property; Proteomics; PubChem; Public Health; Quantitative Structure-Activity Relationship; reproductive toxicity; Research; research clinical testing; Research Personnel; Resources; Response Elements; Risk; Safety; safety assessment; safety testing; screening; search engine; Signal Transduction; Source; Statutes and Laws; System; Test Result; Testing; Time; tool; Toxic effect; toxicant; Toxicology; transcriptomics; Translating; Validation; Vertebrates; virtual; web portal; ","Mechanism-Driven Virtual Adverse Outcome Pathway Modeling for Hepatotoxicity","031080","BDMA","Biodata Management and Analysis Study Section ","","","01","303376","162316","465692",""
"9821171","F32","AG","5","N","05/20/2020","04/01/2020","03/31/2021","866","F32AG057107","ORGANIZED RESEARCH UNITS","PA-16-307","5F32AG057107-03","NIA:67446\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE ON AGING","","BERKELEY","UNITED STATES","NEUROSCIENCES","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947101749","Project Narrative This proposal is focused on measuring the progression of tau pathology, one of the hallmarks of Alzheimer's disease (AD), and on downstream effects of tau on functional connectivity and memory performance in healthy older adults who may be in the preclinical phase of AD. Characterizing the progression of tau pathology, the severity of which is closely related to cognition, in healthy older adults using longitudinal PET imaging will help to differentiate normal aging from pathological aging, with the long-term goal of identifying individuals who would benefit from effective intervention. Local and distant functional connectivity changes associated with tau pathology progression may be indicators of a pathological aging trajectory and reveal aspects of the mechanism underlying the close association between tau burden and cognition. 1","11517742; ","HARRISON, THERESA M.;","WISE, BRADLEY C","12/01/2017","03/31/2021","abeta accumulation; abeta deposition; Accounting; AD pathology; Adult; Affect; Aging; Alzheimer's Disease; American; Amyloid beta-Protein; Amyloid deposition; Anatomy; Area; Autopsy; base; Behavior; Behavioral; Behavioral Symptoms; Binding; Biological Assay; Biological Markers; Brain; Cessation of life; Clinical; Clinical Trials Design; Cognition; Cognitive; Cohort Studies; Data; Dementia; density; Deposition; design; Diagnosis; Disease; Distant; Early Intervention; effective intervention; Effectiveness; Elderly; entorhinal cortex; Environment; follow-up; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Hippocampus (Brain); Human; Impaired cognition; Impairment; in vivo; Individual; Intervention; Light; Link; longitudinal analysis; longitudinal dataset; longitudinal positron emission tomography; Measures; Medial; Mediating; Memory; mild cognitive impairment; multimodality; neuropathology; normal aging; novel; novel strategies; Outcome; Participant; Pathogenesis; pathological aging; Pathology; Performance; Phase; Population; Positron-Emission Tomography; potential biomarker; pre-clinical; prevent; Process; Proxy; radiotracer; Research; Research Personnel; Risk; Scanning; Severities; Severity of illness; Spinal Tap; Staging; Symptoms; tau aggregation; tau Proteins; Temporal Lobe; Terminal Disease; therapy design; Time; Tissues; Tracer; Work; ","Tracking Tau with In Vivo Braak Staging: Longitudinal Analysis of Tau Pathology and Functional Sequelae in Cognitively Healthy Older Adults","057107","ZRG1","Special Emphasis Panel ","","","03","67446","","67446",""
"10094744","R01","HL","7","N","05/19/2020","05/20/2020","04/30/2021","837","R01HL130399","SCHOOLS OF MEDICINE","PA-18-590","7R01HL130399-05","NHLBI:386250\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","IOWA CITY","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","062761671","US","3972901","UNIVERSITY OF IOWA","IA","522421320","PUBLIC HEALTH RELEVANCE: Peripheral arterial disease (PAD) of the lower extremities is the result of arteriosclerotic blockage of blood vessels and its severity varies even among people with similar occlusions, suggesting a possible role for genetics in its severity. Individual with PAD and diabetes are at much higher risk of amputation and death. We have identified a gene called ADAM12 that improves recovery of blood flow after a vessel is blocked. We have found that diabetes appears to impair regulation of this gene in humans and in rodents such that its expression is blunted in muscles with poor blood flow. Therefore we would like to better understand how this gene works to improve blood flow and determine how to manipulate this for therapy in PAD especially in individuals with diabetes.","10505242; ","DOKUN, AYOTUNDE OLUROPO;","GALIS, ZORINA S","05/01/2016","04/30/2021","3-Dimensional; Affect; American; Amputation; angiogenesis; Ankle; arm; Atherosclerosis; base; biobank; Biological Assay; Biopsy; Blood flow; Blood Vessels; C57BL/6 Mouse; Cell Proliferation; Cell Survival; Cessation of life; Chromosome 7; Clinical; Complication; Data; Diabetes Mellitus; differential expression; Disease Outcome; Endothelial Cells; Endothelium; Exposure to; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Genes; Genetic; Genetic Polymorphism; high risk; Human; Hypoxia; Immunoprecipitation; Impairment; improved; In Vitro; in vivo; Inbred BALB C Mice; indexing; Individual; Ischemia; knock-down; Limb structure; Lower Extremity; Manipulative Therapies; Measures; Mediating; Medical; Messenger RNA; MicroRNAs; Mouse Strains; Mus; Muscle; Necrosis; Non-Insulin-Dependent Diabetes Mellitus; Outcome; overexpression; Pathway interactions; Patients; Perfusion; Peripheral arterial disease; Play; pre-clinical; Pre-Clinical Model; prevent; progenitor; protein expression; public health relevance; Quantitative Trait Loci; Receptor Activation; Receptor Protein-Tyrosine Kinases; Recovery; Regulation; Risk; RNA; Rodent; Role; Severities; Severity of illness; Single Nucleotide Polymorphism; Skeletal Muscle; Testing; Therapeutic; Therapeutic Effect; TIE-2 Receptor; Time; Tissues; Tube; Up-Regulation; Walking; Work; ","Modulation of miR29a and ADAM12 to improve peripheral arterial disease","130399","VCMB","Vascular Cell and Molecular Biology Study Section ","","","05","250000","136250","386250",""
"9937165","P01","AG","2","N","05/22/2020","04/01/2020","03/31/2021","","P01AG002132","","PAR-18-297","2P01AG002132-39","NIA:355117\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","8730935; ","SOUTHWORTH, DANIEL RYLAND;","","","","Address; Adopted; advanced disease; Affinity; Aging; Alzheimer's Disease; Amyloid; Amyloid beta-Protein; Amyloid Fibrils; amyloid formation; amyloid structure; Animal Model; Animals; Antibodies; base; beta pleated sheet; Binding; Biological Models; Brain; brain tissue; Cell Culture Techniques; Cells; chaperone machinery; Characteristics; Complex; crosslink; Cryoelectron Microscopy; Data; Dementia; Disease; Disease model; Disease Progression; disease-causing mutation; experience; Filament; Film; functional group; Future; genetic regulatory protein; Goals; graphene; Heat-Shock Proteins 70; Human; human tissue; In Vitro; in vivo; interest; K-18 conjugate; Length; Mediating; Methods; Modeling; Modification; Molecular; Molecular Chaperones; Molecular Conformation; Molecular Structure; mouse model; Mus; mutant; Mutation; Neurodegenerative Disorders; Neurofibrillary Tangles; new therapeutic target; novel therapeutic intervention; Nucleotides; Oxides; Pathologic; Peptides; Pharmacology; Population; prevent; Prions; Process; Protein Isoforms; Proteins; Quality Control; Regulation; Resolution; response; Senile Plaques; small molecule; Source; Structure; Surface; System; tau aggregation; tau Proteins; Technology; Therapeutic; Tissues; Toxic effect; ubiquitin-protein ligase; Ubiquitination; Variant; Work; ","Project 3: Structural basis of amyloid formation and chaperone-mediated turnover","002132","ZAG1","Special Emphasis Panel ","6196","","39","220000","135117","","355117"
"9992017","F30","DK","1","N","02/13/2020","05/16/2020","05/15/2021","847","F30DK124987","SCHOOLS OF MEDICINE","PA-19-192","1F30DK124987-01","NIDDK:45134\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","EAST LANSING","UNITED STATES","PHARMACOLOGY","08","193247145","US","5245901","MICHIGAN STATE UNIVERSITY","MI","488242600","Project Narrative Constipation in Parkinson?s disease drastically decreases the quality of life of 24-63% of patients. This project will investigate a novel mechanism on the role of aggregated ?-synuclein in neuromuscular and synaptic neurotransmission in the enteric nervous system that will assist in identifying new drug targets for the treatment of constipation in Parkinson?s disease.","15895079; ","YELLESWARAPU, NARAYANA KRISHNA;","DENSMORE, CHRISTINE L","05/16/2020","05/15/2024","Address; alpha synuclein; Animal Model; Bathing; Biological Assay; cell motility; cholinergic; cholinergic neuron; Clinical; Colon; Confocal Microscopy; Constipation; Data; Dietary Intervention; Digestion; Distal; Dopaminergic Agents; drug discovery; Eating; Economic Burden; Ectopic Expression; effective therapy; Electrodes; Electrophysiology (science); Enteral; Enteric Nervous System; gastrointestinal; Gastrointestinal tract structure; Goals; Health; Health Professional; Immunohistochemistry; Impairment; in vivo; Individual; Isometric Exercise; Knowledge; Label; laxative; Lead; Light; Link; Mediating; Migrating Myoelectric Complex; motility disorder; Motor; motor deficit; motor impairment; Motor Neurons; mouse model; Mus; Myenteric Plexus; Neuraxis; Neurodegenerative Disorders; neuromuscular; neuromuscular transmission; neuronal circuitry; Neurons; neurotransmission; Neurotransmitters; new therapeutic target; novel; novel therapeutics; optogenetics; Organ; Output; overexpression; Parkinson Disease; Pathologic; Pathologic Processes; Pathology; Patients; Pattern; Pharmacotherapy; Physical therapy; Point Mutation; Population; Presynaptic Terminals; Proteins; Quality of life; Recombinant adeno-associated virus (rAAV); Relaxation; Research; retrograde transport; Role; Smooth Muscle; Smooth Muscle Myocytes; Symptoms; Synapses; Synaptic Transmission; Synaptic Vesicles; System; targeted treatment; Testing; Time; Tissues; Transgenic Organisms; Weight; ","Enteric Neuronal Aggregation of a-synuclein causes disruption in Colonic Neurotransmission and results in Colonic Dysmotility","124987","ZRG1","Special Emphasis Panel ","","","01","45134","","45134",""
"10131462","U01","DK","3","N","05/21/2020","02/01/2020","01/31/2021","847","U01DK057219","SCHOOLS OF MEDICINE","RFA-DK-15-501","3U01DK057219-22S1","NIDDK:85001\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","Los Angeles","UNITED STATES","INTERNAL MEDICINE/MEDICINE","37","072933393","US","7636101","UNIVERSITY OF SOUTHERN CALIFORNIA","CA","900890701","PUBLIC HEALTH RELEVANCE: Weight loss is recommended for overweight and obese individuals with type 2 diabetes, but the long-term effects of such approaches on the issues of greatest concern to older individuals --including mortality, health care utilization and costs, diabetic complications, quality of life, and frailty -- remain untested. The Look AHEAD-Extension will follow approximately 3800 of these individuals for an additional 4.5 years to determine whether random assignment to an intensive lifestyle intervention focused on weight loss achieved through healthy eating and increased physical activity relative to a control group leads to improved long-term health in later life. This extended follow-up will provide important information about the long-term beneficial effects of a lifestyle intervention in a growing segment of the population-namely those who are older, overweight or obese, and have type 2 diabetes.","7038959; ","PETERS, ANNE L;","KUCZMARSKI, ROBERT J","09/30/1999","01/31/2021","Address; adult obesity; Age; Age-Years; Aging; Ancillary Study; Biochemical; Body Weight decreased; Bone Density; Cardiovascular Diseases; Caring; Clinic Visits; Clinical; Clinical Trials; cohort; comorbidity; Complications of Diabetes Mellitus; Control Groups; cost; cost effective; Data; Data Analyses; Diabetes Mellitus; diabetic; Dimensions; Disease; Education; Elderly; Event; Face; Fatty acid glycerol esters; follow-up; frailty; functional disability; Genetic; Goals; group intervention; Guidelines; Health; Health Care Costs; health care service utilization; Healthcare; healthy aging; Healthy Eating; improved; Incidence; Independent Living; Individual; Infrastructure; Intervention; Kidney Diseases; Lead; Life; lifestyle intervention; Long-Term Effects; Longevity; Measures; medical complication; Microvascular Dysfunction; middle age; mortality; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; outcome prediction; Overweight; Participant; Pathway interactions; Patient-Focused Outcomes; Persons; Phase; Physical activity; Physical Function; Population; post intervention; primary outcome; Process; programs; Public Health; public health relevance; Publications; Quality of life; Randomized; Randomized Controlled Clinical Trials; randomized trial; Recording of previous events; Reporting; Research Project Grants; research study; resilience; secondary outcome; Subgroup; Telephone; Testing; Thinness; trial comparing; Uncontrolled Study; Weight; Weight Gain; ","15/16 Action for Health in Diabetes Extension Study Research Project","057219","ZDK1","Special Emphasis Panel ","","S1","22","67461","17540","85001",""
"10144851","I01","VA","5","N","05/21/2020","04/01/2020","09/30/2020","999","I01RX000559","","RFA-RX-14-010","5I01RX000559-10","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","PORTLAND","UNITED STATES","","03","089461255","US","481073","PORTLAND VA MEDICAL CENTER","OR","972392964","PUBLIC HEALTH RELEVANCE:     Diabetes Mellitus (DM) affects 20-30% of Veterans receiving care at the VA. Previous work from our group demonstrates effects of diabetes at peripheral-, brainstem- and cognitive levels of auditory processing that, though found primarily among Veterans under age 50, are reminiscent of changes from presbycusis among older, non-diabetics. Our goal is to further survey auditory system measures in a valuable cohort of Veterans with DM as functional deficits in hearing and speech comprehension are continuing to emerge. We will contrast differences from normal aging, determine the DM characteristics that are risk factors for premature auditory senescence, and develop longitudinal trajectory predictions of auditory dysfunction given an individual Veteran's risk profile. Additionally in this continuation proposal, we introduce measures of temporal processing, and longitudinal assessment in a mouse model to determine the specific consequences of diabetes that are strongly (possibly causally) related to key measures of auditory dysfunction.","9612162; 8386387 (contact); ","DILLE, MARILYN F.; KONRAD-MARTIN, DAWN L (contact);","","04/01/2015","09/30/2020","Acoustic Nerve; Acoustics; Address; Adverse effects; Affect; Age; Age of Onset; age related; Aging; Animal Model; Auditory; auditory pathway; auditory processing; auditory stimulus; Auditory system; Auditory Threshold; austin; base; behavior measurement; Behavioral; Benchmarking; Biological; Blindness; Brain; Brain Stem; Caring; Characteristics; clinical Diagnosis; Clinical Trials; clinically significant; Cochlea; Cognition; Cognitive; cognitive change; cognitive function; cohort; Cohort Studies; Communication impairment; comorbidity; Complex; Comprehension; Cross-Sectional Studies; Cues; Data; Deterioration; Diabetes Mellitus; Diagnosis; disability; Disease; Economics; Emotional; Exhibits; Eye; Functional disorder; Future; glycemic control; Glycosylated hemoglobin A; Goals; Health; Hearing; hearing impairment; High Fat Diet; Human; Hyperglycemia; Hyperlipidemia; Hypertension; Impaired cognition; Impairment; improved; Individual; Insulin; Intervention; Kidney; Kidney Diseases; Knowledge; knowledge base; Laboratories; Labyrinth; Link; Longitudinal Studies; Longitudinal trends; macrovascular disease; Measures; Metabolic Control; Metabolic Diseases; Metabolic syndrome; Mission; Molecular; Morbidity - disease rate; mouse model; Mus; Nature; Neurologic; Neurons; Neuropathy; non-diabetic; Non-Insulin-Dependent Diabetes Mellitus; normal aging; Outcome; Output; Patients; Peripheral; Personal Satisfaction; Phenotype; Physiological; Population; Predictive Factor; predictive modeling; premature; Presbycusis; prevent; Prevention; Procedures; Process; programs; prospective; public health relevance; Publishing; Quality of life; relating to nervous system; Research; Retina; Retinal; Risk; Risk Factors; senescence; Sensory; Severities; Severity of illness; social; Speech; Statistical Models; Surveys; Testing; Time; Veterans; Work; ","Longitudinal Changes in Auditory Function Among Veterans with Diabetes","000559","RRD3","Sensory Systems & Communication Disorders ","","","10","","","",""
"9906233","P01","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P01GM095467","","PAR-13-280","5P01GM095467-10","NIGMS:268838\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","","1887763; ","SERHAN, CHARLES NICHOLAS;","","","","Acute; Biological; Biophysics; CD59 Antigen; cost; cost effective; experience; Goals; Group Meetings; Human Resources; Individual; Inflammation; instrument; Isomerism; lipid mediator; Location; Mediator of activation protein; meetings; metabolomics; Methods; Mission; novel; Organic Synthesis; Pathway interactions; Pharmacology; physical property; Procedures; programs; Protocols documentation; Research Personnel; Resolution; Resources; Role; Services; Standardization; Structure; Time; tissue injury; Tissues; Validation; ","Core B: Lipid Mediator-SPM Lipidomics","095467","ZGM1","Special Emphasis Panel ","6579","","10","164377","104461","","268838"
"9965302","R01","HG","1","N","05/22/2020","05/22/2020","03/31/2021","172","R01HG010514","BIOMED ENGR/COL ENGR/ENGR STA","RFA-HG-18-001","1R01HG010514-01A1","NHGRI:539479\","Non-SBIR/STTR RPGs","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","NEW YORK","UNITED STATES","ENGINEERING (ALL TYPES)","13","049179401","US","1833202","COLUMBIA UNIV NEW YORK MORNINGSIDE","NY","100277922","Narrative High throughput next-generation DNA sequencing has penetrated all areas of biology and medicine, promising to transform preventive medicine and public health, but substantial improvements in accuracy, throughput, and costs of instrumentation and analysis are needed to make the technology truly accessible. To address these issues, we have developed a new Nanopore-based Sequencing-by-Synthesis platform, which allows real-time single-molecule electronic DNA sequencing. In this proposal, we will design and synthesize novel tagged nucleotides and construct nanopore- polymerase conjugates to control the speed of the sequencing reaction and increase the single-molecule sequencing accuracy substantially.","1925956; 8073329 (contact); 6172332; ","CHURCH, GEORGE M; JU, JINGYUE  (contact); KALACHIKOV, SERGEY ;","SMITH, MICHAEL","05/22/2020","03/31/2023","Address; Affinity; Area; Bacterial Genome; Bar Codes; base; Binding; Biological Assay; Biology; carbene; Circular DNA; Complex; cost; Data; design; Detection; Development; DNA; DNA Library; DNA sequencing; DNA-Directed DNA Polymerase; Electrodes; Enzyme Kinetics; Enzymes; Evaluation; Event; Funding; gel electrophoresis; genome sequencing; Genomic DNA; Hemolysin; improved; Individual; innovation; inorganic phosphate; insertion/deletion mutation; instrumentation; Isomerism; Kinetics; Length; Libraries; Lipid Bilayers; Measurement; Measures; Medicine; Methods; Modification; Morphologic artifacts; nanopore; next generation; novel; Nucleic acid sequencing; nucleotide analog; Nucleotides; Pattern; Performance; Polymerase; Polymers; Polyphosphates; Positioning Attribute; Preventive Medicine; process optimization; Property; Protocols documentation; Public Health; Reaction; Reaction Time; Reporting; research and development; Resolution; Sampling; screening; sensor; Sequence Deletion; Sequence Determination; sequencing platform; Series; Signal Transduction; single molecule; Speed; Stuttering; synthetic construct; System; Technology; Testing; thiophosphate; Time; United States National Institutes of Health; Viral; Viral Genome; Work; ","Single-Molecule Electronic Nucleic Acid Sequencing-by-Synthesis Using Novel Tagged Nucleotides and Nanopore Constructs","010514","ZHG1","Special Emphasis Panel ","","A1","01","360853","178626","539479",""
"9933899","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:447226\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1883513; ","STEIN, ROLAND W;","","","","Abbreviations; Academic Medical Centers; Anesthesiology; Award; Awareness; Behavioral Research; Biological Assay; Biomedical Research; Biophysics; career; Categories; Chemistry; Communities; Core Facility; Critiques; Data; Diabetes Mellitus; Discipline; Effectiveness; epidemiology study; Faculty; Funding; Funding Mechanisms; Goals; Grant; Hormones; Individual; innovation; Institution; Leadership; Measures; Medicine; member; Metabolic; metabolic phenotype; Molecular; Mus; novel; Ophthalmology; Pediatrics; Peer Review Grants; Pharmacology; Physiology; Program Reviews; programs; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Research Training; Resource Sharing; Review Committee; Services; Source; Study Section; success; Time; United States National Institutes of Health; Universities; vision science; Work; ","Pilot and Feasibility Program","020593","ZDK1","Special Emphasis Panel ","7651","","43","289466","157760","","447226"
"10008615","R44","DK","2","N","05/19/2020","05/20/2020","03/31/2021","847","R44DK117726","","PA-19-272","2R44DK117726-02A1","NIDDK:892209\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","ROCKVILLE","UNITED STATES","","06","073956457","US","10045644","RISE THERAPEUTICS, LLC","MD","208506345","Project Narrative Over 3 million adults in the U.S. suffer from inflammatory bowel disease (IBD). This project aims to develop a tailored probiotic therapy, R-3750, which delivers SlpA to induce local colonic regulatory T cells for the treatment of IBD. Oral delivery of SlpA reduces gut inflammation, reestablishes gut mucosal barrier function, induces positive maintenance of the gastrointestinal microbiome, and eliminates symptoms of experimental colitis. Based upon these properties, commercialization of R-3750 could provide an important new IBD treatment that is oral-based, safer than current drug options, and potentially lower cost.","14958505; ","FANGER, GARY ;","DENSMORE, CHRISTINE L","07/01/2018","09/30/2022","Adult; Animal Model; Animals; Bacteria; base; Binding; Biological; Biological Assay; Biological Markers; biomarker identification; Biomass; C Type Lectin Receptors; C-Type Lectins; CD209 gene; Cell Adhesion Molecules; cell bank; Cells; Chemicals; Chronic; Climacteric; Clinical; Clinical Research; Clinical Trials; Colitis; commensal bacteria; commercialization; cost; Crohn's disease; cytokine; Data; Dendritic Cells; design; Development; Diagnosis; Digestive System Disorders; Disease; dosage; Dose; drug development; Engineering; Environment; Environmental Risk Factor; Experimental Models; Food; Future; gastrointestinal; Genetic Engineering; genetic manipulation; Goals; Growth; gut microbiome; Gut Mucosa; Homeostasis; Homologous Gene; host microbiota; Human; Human Microbiome; Immune; immune health; Immune system; Immunity; Immunologics; improved; Industry; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; innovation; interest; Interleukin-10; intestinal epithelium; Intestines; Investments; lactic acid bacteria; Lactobacillus; Lactococcus; Life; Ligands; lipoteichoic acid; Maintenance; manufacturing scale-up; Mediating; Medical; Membrane; Methods; microbiome; microbiota; Modeling; Mucous Membrane; Mus; normal microbiota; novel; novel therapeutics; Nutrient; Oral; overexpression; Patients; Pattern recognition receptor; Pharmaceutical Preparations; Pharmacodynamics; pharmacokinetics and pharmacodynamics; Pharmacologic Substance; Phase; Play; Population; Preparation; prevent; probiotic therapy; Probiotics; Process; Property; Proteins; receptor; Recombinants; Regulatory T-Lymphocyte; Research; research clinical testing; Research Design; Role; scale up; side effect; Signal Transduction; Small Business Innovation Research Grant; Stomach; success; Surface; Symptoms; Therapeutic; Thymidine; Toxicology; Ulcerative Colitis; vaccine delivery; vector; ","A Novel Immunological Probiotic for Treating Inflammatory Bowel Disease","117726","ZRG1","Special Emphasis Panel ","","A1","02","","","892209",""
"10147037","P30","CA","3","N","05/18/2020","04/01/2020","03/31/2021","","P30CA138292","","PAR-13-386","3P30CA138292-12S2","NCI:59999\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","ATLANTA","UNITED STATES","","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","","3150751; ","VAN MEIR, ERWIN G;","HE, MIN","","","Abnormal Cell; Affect; angiogenesis; anticancer research; Area; Attenuated; Award; base; Basic Science; BCL2 gene; Biological Markers; BRAF gene; Cancer Biology; cancer biomarkers; Cancer Burden; cancer care; cancer cell; Cancer Center; Cancer Center Support Grant; Cancer Patient; cancer stem cell; cancer therapy; Caring; Cell Communication; Cell Death; cell growth; cell motility; Cell physiology; Cell Proliferation; Cell Survival; cell transformation; Cells; Cellular biology; Cessation of life; Classification; Clinic; Clinical; clinical practice; Clinical Research; clinical translation; Collaborations; collaborative environment; college; Complex; design; Development; Diet; Doctor of Philosophy; Enzymes; Epithelial; Epithelium; Event; Family; Funding; Generations; Genetic; Genomics; Glioma; Goals; Growth; Growth Factor Receptors; High Fat Diet; Homeostasis; Human; Hypoxia; Immune; Infrastructure; inhibitor/antagonist; innovation; Institutes; interest; Knowledge; Laboratories; Leadership; Lipids; Malignant Neoplasms; medical schools; melanoma; member; Mesenchymal; Metabolic; Mission; Molecular; multidisciplinary; Mus; mutant; Mutation; Neoplasm Metastasis; Neoplasms; neoplastic cell; neovascularization; novel; novel therapeutics; Patients; Phenotype; Plant Roots; Post-Translational Protein Processing; Pre-Clinical Model; predictive marker; Process; profiles in patients; prognostic; Prognostic Marker; programs; Proteome; Publications; Publishing; receptor; Regulation; Research; Research Personnel; Resource Sharing; Science; Scientific Advances and Accomplishments; Signal Pathway; Signal Transduction; success; Testing; The Cancer Genome Atlas; therapeutic development; therapeutic target; therapy resistant; Thrombosis; Translating; tumor; tumor growth; tumor metabolism; tumor microenvironment; Universities; Work; ","Cancer Cell Biology","138292","NCI","Subcommittee I - Transistion to Independence ","8757","S2","12","38461","21538","","59999"
"9923778","R35","NS","5","N","05/20/2020","05/01/2020","04/30/2021","853","R35NS111644","SCHOOLS OF MEDICINE","RFA-NS-18-032","5R35NS111644-02","NINDS:1121140\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","SAN FRANCISCO","UNITED STATES","NEUROLOGY","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","Multiple sclerosis is a common and disabling autoimmune disease of the central nervous system in which B cells play a central pathogenic role. The principal goal of the project is to identify the disease trigger(s), and to understand the mechanisms underlying disease progression. Central elements of this initiative include large well-characterized clinical populations, comprehensive biobanked materials, serial magnetic resonance imaging of the brain and spinal cord using novel quantitative techniques, complete genetic information, and state of the art tools to investigate B cell biology including single cell B cell transcriptomics, recombinant antibody libraries, and phage-displayed synthetic protein arrays to identify antibody reactivities against foreign and self proteins.","1862648; ","HAUSER, STEPHEN L;","UTZ, URSULA","05/01/2019","04/30/2027","Acute; Affect; Antibodies; antibody libraries; Axon; B-Lymphocytes; biobank; Brain imaging; Cellular biology; Cerebrospinal Fluid; Chronic; chronic autoimmune disease; Clinical; CNS autoimmune disease; cohort; Data; Disease; Disease Progression; Elements; falls; Fingerprint; Genetic Determinism; genetic information; Goals; Human; improved; Individual; Inflammation; Magnetic Resonance Imaging; Mediating; microbial; Molecular; Multiple Sclerosis; Myelin; Neurologic Dysfunctions; Neurons; novel; Oligodendroglia; Onset of illness; Pathogenicity; Pathology; Patient-Focused Outcomes; Patients; peripheral blood; Phage Display; Pharmaceutical Preparations; Play; Population; Progressive Disease; Protein Array; Proteins; receptor; Recombinant Antibody; Research; Role; screening; Serum; Spinal Cord; synthetic protein; Techniques; Technology; Therapeutic; tool; transcriptomics; United States; Viral; ","The Role of B cells in the Origin and Progression of Multiple Sclerosis","111644","ZNS1","Special Emphasis Panel ","","","02","699218","421922","1121140",""
"9969022","U01","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","U01AI151812","","RFA-AI-19-028","1U01AI151812-01","NIAID:1955218\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LA JOLLA","UNITED STATES","","49","781613492","US","7375802","SCRIPPS RESEARCH INSTITUTE","CA","920371000","In recent years, severe outbreaks and epidemics of Ebola, Lassa, and Zika have illustrated how vulnerable the world is to threats from RNA viral pathogens. To counter the dangers posed by these viruses, we must develop flexible and scalable technologies for diagnostics, surveillance, pathogen discovery and transmission, and deploy them in the most outbreak-prone regions of the world. Here, we will establish the West African Emerging Infectious Diseases Research Center with partners in the United States, Senegal, Sierra Leone, Liberia, and Nigeria, to develop effective strategies, and deploy the necessary tools, for detecting, mitigating, and preventing future outbreaks from emerging and re-emerging infectious diseases.","10971328 (contact); 1940874; 9410597; ","ANDERSEN, KRISTIAN GRAUGAARD (contact); GARRY, ROBERT F; SABETI, PARDIS CHRISTINE;","PATTERSON, JEAN LOIS","05/21/2020","04/30/2025","Acute; Affect; Africa; African; Animals; Area; Awareness; base; Biological Assay; Chiroptera; Clinical; Clinical Management; Clustered Regularly Interspaced Short Palindromic Repeats; cohort; Collaborations; Communicable Diseases; Communication; Communities; computerized tools; Country; data sharing; Decentralization; Detection; Development; Diagnostic; diagnostic assay; Diagnostic tests; Disease Outbreaks; Ebola; Educational workshop; Emerging Communicable Diseases; Ensure; Epidemic; Epidemiologist; Evolution; experience; flexibility; Foundations; Frequencies; Funding; Future; genome sequencing; Genomics; Goals; Health; Human; Immune response; improved; Infection; Infectious Diseases Research; Infrastructure; Knowledge; Lassa virus; Liberia; metagenomic sequencing; Metagenomics; Methods; microbial; Molecular Epidemiology; National Institute of Allergy and Infectious Disease; Natural History; new technology; Nigeria; novel; Outcome; pandemic disease; pandemic preparedness; pathogen; Pathogenesis; pathogenic virus; Patients; Plant Roots; Prevalence; prevent; Prevention strategy; priority pathogen; Protocols documentation; Public Health; public health emergency; public health intervention; Reagent; Research; Research Personnel; response; Risk; Risk Factors; RNA Viruses; Rodent; Security; Senegal; Sierra Leone; Standardization; surveillance study; Surveys; System; Technology; technology development; Technology Transfer; Testing; tool; Training; transmission process; United States; United States National Institutes of Health; Viral Hemorrhagic Fevers; viral RNA; viral transmission; Virus; Virus Diseases; Work; World Bank; ZIKA; ","West African Emerging Infectious Disease Research Center (WA-EIDRC)","151812","ZAI1","Special Emphasis Panel ","","","01","1534498","420720","1955218",""
"10043222","R03","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R03AI153902","SCHOOLS OF MEDICINE","PA-19-052","1R03AI153902-01","NIAID:78000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BURLINGTON","UNITED STATES","SURGERY","00","066811191","US","8738101","UNIVERSITY OF VERMONT & ST AGRIC COLLEGE","VT","054051704","Innate-like T cells are unusual T cells that play important roles in mounting anti-microbial and anti-tumor immune responses in tissues like the gut, skin, and lung. However, while the innate-like ?? T cell subsets are well-defined, we still know very little about the innate-like ?? T cell subsets. Since all innate-like T cell subsets identified so far are characterized by i) a highly restricted T cell receptor and ii) a dependence on the SLAM/SAP signaling pathway for their development, we propose to identify new innate-like ?? T cell subsets by using single-cell next generation sequencing to identify ?? T cell receptors whose development is dependent on SLAM/SAP signaling.","2445443; ","BOYSON, JONATHAN E;","KELLY, HALONNA R","05/22/2020","04/30/2022","adaptive immune response; Adaptor Signaling Protein; Adult; Affect; anti-tumor immune response; antimicrobial; Applications Grants; Area; Bacteria; Bar Codes; Birth; Cells; Characteristics; chemokine; cytokine; Data; Data Set; Dependence; Development; Embryo; Exhibits; Family; Frequencies; fungus; Hematopoietic; Immune response; Impairment; Interferons; Interleukin-17; Interleukin-4; Investigation; Laboratories; Libraries; Lung; Lymphocyte; Lymphoid Tissue; Microbe; Mucous Membrane; Mus; neonate; next generation; next generation sequencing; novel; Organ; Pathway interactions; Peripheral; Play; Population; receptor; Receptor Signaling; Research Personnel; Resolution; Role; SH2D1A gene; Shapes; Signal Pathway; Signal Transduction; Skin; SLAM family receptor; Spleen; T-Cell Development; T-Cell Receptor; T-cell receptor repertoire; T-Lymphocyte; T-Lymphocyte Subsets; Thymus Gland; Tissues; Tumor Immunity; Virus; ","Defining the SAP-dependent and SAP-independent gamma delta TCR repertoire","153902","CMIA","Cellular and Molecular Immunology - A Study Section ","","","01","50000","28000","78000",""
"9906237","P01","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P01GM095467","","PAR-13-280","5P01GM095467-10","NIGMS:368257\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","","1885099; ","LEVY, BRUCE D;","","","","Acids; Acute; Adult Respiratory Distress Syndrome; airway epithelium; airway inflammation; Anabolism; Anti-inflammatory; Anti-Inflammatory Agents; antimicrobial peptide; Arachidonate 5-Lipoxygenase; Bacteria; Bacterial Infections; base; Biological Process; Biopsy; bronchial epithelium; Bulla; CD59 Antigen; celecoxib; Cell Communication; cell type; Cells; Clinical; Collaborations; comparative; Critical Illness; cyclooxygenase 2; cytokine; Data; design; Development; Docosahexaenoic Acids; Dose; Edema; Epithelial; Epithelial Cells; Epithelium; Escherichia coli; Experimental Models; Exposure to; Exudate; functional restoration; Funding; Gastric Acid; Generations; Histology; Host Defense; Human; Hydrochloric Acid; Image Analysis; Immune; Impairment; in vivo; Infection; Inflammation; Inflammatory Response; injured; injured airway; Injury; insight; interest; Lead; Leukocyte Trafficking; Leukocytes; Lung; Lung Inflammation; macrophage; Mechanics; Mediator of activation protein; Modeling; Molecular; Morbidity - disease rate; Mucositis; Mucous Membrane; neutrophil; non-invasive imaging; novel therapeutic intervention; novel therapeutics; Organ; Pharmacologic Substance; Pharmacology; Pneumonia; Polyunsaturated Fatty Acids; Predisposition; prevent; Production; programs; Property; Publishing; Pulmonary aspiration of gastric contents; recruit; Regulation; Reporting; Resolution; Resources; respiratory; Respiratory Mechanics; response; response to injury; Role; Secondary to; Severities; Signal Pathway; Site; Skin; Structure of parenchyma of lung; Structure-Activity Relationship; Surface; synergism; Testing; Time; tissue injury; Tissue Model; tissue regeneration; Tissues; Zileuton; ","Project 2: Specialized Pro-Resolving Mediators in the Resolution of Airway Injury","095467","ZGM1","Special Emphasis Panel ","6582","","10","235346","132911","","368257"
"10132065","R01","AI","3","N","05/21/2020","05/21/2020","01/31/2021","855","R01AI145687","SCHOOLS OF MEDICINE","PA-18-935","3R01AI145687-02S1","NIAID:732990\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","DURHAM","UNITED STATES","SURGERY","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","The causative virus behind the COVID-19 disease, SARS-CoV-2, uses a highly flexible protein on its surface to gain access to host cells. Here, using a combination of computational tools and high-resolution microscopy, we aim to define how this inherent flexibility impacts the manner in which our immune systems respond to the virus. This information will be used to optimize vaccines with enhanced efficacy and will provide critical information for the development of therapeutics.","15579240; ","ACHARYA, PRIYAMVADA ;","REFSLAND, ERIC WILLIAM","05/21/2020","01/31/2022","2019-nCoV; Antibodies; Antiviral Agents; Behavior; Behavior Disorders; Binding; Biochemical; Biological Assay; biophysical properties; Biophysics; C-terminal; Cell fusion; Cells; Chimeric Proteins; Communities; computerized tools; conformational conversion; Coronavirus; Coronavirus spike protein; COVID-19; Cryoelectron Microscopy; Data; design; detector; Development; Devices; Disease; drug candidate; Drug Design; Electron Microscope; Electrons; Event; Exhibits; expectation; experimental study; flexibility; global health emergency; Goals; Grant; HIV-1; Immune system; in silico; Infection; Information Dissemination; innovation; insight; Kinetics; Ligand Binding; Ligands; Microscopy; Molecular Conformation; molecular dynamics; Motion; Movement; mutant; Mutation; N-terminal; novel; pandemic disease; Pathway interactions; Patients; Peptide Hydrolases; Pharmaceutical Preparations; Play; Positioning Attribute; Preventive treatment; Process; protein expression; protein structure; Proteins; receptor; receptor binding; Research Personnel; Resolution; response; Role; Sampling; Severe Acute Respiratory Syndrome; Source; Specificity; stem; Structural Biochemistry; Structure; Surface; Techniques; Theoretical model; Therapeutic; therapeutic development; thermostability; Titan; vaccine candidate; Vaccine Design; vaccine development; Vaccines; Variant; Viral; Virus; ","Structures of initial CD4 engagement with pre-fusion, closed HIV-1 Envelope trimer and early CD4-induced conformational changes required for infection","145687","","","","S1","02","455273","277717","732990",""
"9850202","R01","AR","5","N","05/20/2020","01/01/2020","12/31/2020","846","R01AR070760","SCHOOLS OF MEDICINE","PA-13-302","5R01AR070760-04","NIAMS:352858\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","HANOVER","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","02","041027822","US","2021601","DARTMOUTH COLLEGE","NH","037551421","Narrative. Systemic lupus erythematosus (SLE, lupus) is an autoimmune disease commonly affecting women in young adulthood. SLE has protean manifestations, the most devastating of which are renal and CNS involvement, both associated with high morbidity and mortality. Although truly extraordinary advances have been made in the treatment of other autoimmune diseases, such as rheumatoid arthritis and ANCA- associated vasculitis, the treatment for lupus remains chemotherapy-based, for the most part effective, but also very toxic. There is clearly an ongoing unmet need for an effective, safe ?biologic? for the treatment of lupus.","1864181; ","NOELLE, RANDOLPH J.;","MANCINI, MARIE","02/10/2017","12/31/2021","Address; Affect; Antibodies; Antibody Formation; Antineutrophil Cytoplasmic Antibodies; Apoptotic; Autoimmune Diseases; Autoimmunity; base; Binding; Binding Proteins; Biological Response Modifier Therapy; Biology; CD4 Positive T Lymphocytes; Cell Compartmentation; Cell Lineage; Cells; chemokine; chemotherapy; cytokine; Data; Dendritic Cells; design; Development; Disease; drug candidate; Effector Cell; Engineering; Event; Family; Genes; Genetic; Genetic Models; Grant; Human; immune function; Immune system; Immunity; Immunoglobulin Domain; Immunoglobulins; Immunologics; In Vitro; in vivo; Inflammatory; Integral Membrane Protein; Interferons; Kidney; Leukocytes; Ligands; Lupus; Lupus Nephritis; Lymphocyte; Mediating; member; Membrane Proteins; Molecular; Morbidity - disease rate; mortality; Mouse Strains; Mus; Myelogenous; Myeloid Cells; National Institute of Arthritis and Musculoskeletal and Skin Diseases; novel; Organ; Pathogenesis; Pathology; Pathway interactions; Phase; Population; prevent; programmed cell death protein 1; Reagent; receptor; receptor function; Regulation; Rheumatoid Arthritis; Role; SLEB1 gene; Specificity; success; Suppressor-Effector T-Lymphocytes; Systemic Lupus Erythematosus; T-Cell Activation; T-Lymphocyte; Testing; Therapeutic; therapeutic target; tool; uptake; Ursidae Family; Vasculitis; Woman; young adult; ","Negative regulation of Lupus by the VISTA Pathway","070760","HAI","Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section ","","","04","235554","117304","352858",""
"9868865","P01","AG","5","N","05/18/2020","03/01/2020","02/28/2021","","P01AG009524","","PAR-13-258","5P01AG009524-25","NIA:182051\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","TAMPA","UNITED STATES","","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","PUBLIC HEALTH RELEVANCE NARRATIVE- Animal Core - 001 Presbycusis, or Age -Related Hearing Loss (ARHL), is the number one communication disorder and number one neurodegenerative condition of our expanding aging population; and comprises one of the top 3 chronic medical conditions, along with arthritis and cardiovascular diseases. The vast majority of people over age 60 are affected by this progressive decline in auditory sensitivity and speech understanding, which are hallmarks of ARHL. Despite this high prevalence of ARHL, there currently are no medical treatments for preventing or reversing permanent hearing loss (ARHL or other types). The thematic focus of this proposal is modulation of presbycusis through biotherapeutics and acoustic treatments. If the experiments proposed here to test hypotheses concerning interventions to modulate the progression of presbycusis are successful, the novel results should lead to clinical trials of the efficacy of these innovative technological, acoustic and drug-related treatments.","2098075; ","WALTON, JOSEPH P;","","","","Acoustic Stimulation; Acoustics; Acute; Affect; Age; Aging; aging auditory system; aging population; Aldosterone; animal colony; Animals; Arthritis; Attention; Auditory; Auditory Brainstem Responses; Auditory Perception; Auditory Threshold; base; Biological Response Modifier Therapy; Breeding; Cardiovascular Diseases; Chronic; Clinical Trials; Communication impairment; Complex; Databases; Date of birth; Diagnostic; Drug Delivery Systems; efficacy trial; Ensure; Environment; Exercise; experimental study; FDA approved; Health; Hearing Tests; High Prevalence; Implant; Inbred Mouse; Inbreeding; innovation; Intervention; Lead; Medical; Mus; Nerve Degeneration; neural correlate; Noise; novel; Operative Surgical Procedures; otoacoustic emission; pathogen; permanent hearing loss; Pharmaceutical Preparations; Presbycusis; Prevalence; prevent; Procedures; programs; Public Health; public health relevance; Rattus; Records; relating to nervous system; Research; Rodent; Secure; Sensorineural Hearing Loss; sex; Social Behavior; sound; Speech; Tattooing; Testing; Time; Tinnitus; Tissue Sample; ","Animal Core","009524","ZAG1","Special Emphasis Panel ","5991","","25","122101","59950","","182051"
"9976341","IK2","VA","5","N","05/21/2020","04/01/2020","03/31/2021","999","IK2RX002488","","RFA-RX-16-019","5IK2RX002488-04","","OTHERS","2020","Veterans Affairs","","DECATUR","UNITED STATES","","04","824835805","US","481023","VETERANS HEALTH ADMINISTRATION","GA","300334004","The proposed research that will result in the development of a preclinical model of repetitive mild traumatic brain injury (TBI) is highly relevant to the military and veteran populations because it is estimated that up 30% of soldiers returning from active war zones have suffered TBIs with over 82% of these being mild TBI or concussions. Additionally, repetitive mild TBI/concussion has been receiving increasing emphasis in view of its prevalence in contact sports and the growing diagnosis of chronic traumatic encephalopathy (CTE). CTE has also been detected in military and veteran personnel.","10340366; ","WHITE, TODD E;","","04/01/2017","03/31/2022","Address; Animals; Anti-inflammatory; Anxiety; Behavior; behavior test; Behavioral; behavioral outcome; Bioinformatics; Blood; Blood specimen; Brain Concussion; Characteristics; Chronic; Chronic Brain Injury; chronic traumatic encephalopathy; controlled cortical impact; Development; Diagnosis; Diagnostic; Diagnostic tests; Encephalitis; Exons; experience; Experimental Animal Model; Experimental Models; experimental study; forced swim test; Foundations; Gene Expression Profile; Genes; Goals; Human; Human Resources; improved; Inflammation; injured; Injury; innovation; Intravenous; Investigational Therapies; Laboratories; Learning; Memory; Mental Depression; Mentors; Methods; mild traumatic brain injury; Military Personnel; Modeling; Molecular; Molecular Profiling; Morehouse School of Medicine; morris water maze; Neuregulin 1; neuroprotection; Neuroprotective Agents; next generation sequencing; novel diagnostics; Outcome; patient population; Patients; Pattern; Performance; persistent symptom; Plant Roots; Play; Population; Pre-Clinical Model; precision medicine; Prevalence; Rattus; Research; Research Proposals; Role; Sample Size; Soldier; Sports; Stroke; Symptoms; targeted treatment; teacher; Techniques; Testing; Therapeutic Trials; Time; tool; transcriptome; transcriptome sequencing; Traumatic Brain Injury; Treatment Protocols; Veterans; War; ","Molecular characterization of a rat model of chronic mild traumatic brain injury","002488","HBCU","VA-ORD Historically Black College and University Research Scientist Training Program ","","","04","","","",""
"9901574","R01","MH","5","N","05/18/2020","04/01/2020","03/31/2021","242","R01MH111267","","PA-16-160","5R01MH111267-04","NIMH:526157\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","CHICAGO","UNITED STATES","","07","074438755","US","1525701","LURIE CHILDREN'S HOSPITAL OF CHICAGO","IL","606112991","One of the biggest revelations from genome-wide sequencing is that the majority of RNA transcripts do not code for proteins. This grant will investigate how the ultraconserved long non-coding RNA Evf2 regulates a novel gene network in GABAergic interneuron precursors. Given that altered GABAergic interneuron function has been directly linked to autism, schizophrenia, epilepsy, sleep, and intellectual disabilities, these studies are critical to understanding the molecular basis for multiple neuropsychiatric disorders.","6623822; ","KOHTZ, JHUMKU DUTT;","BEER, REBECCA LYNN","05/24/2017","03/31/2022","3-Dimensional; Adult; Affect; ATP phosphohydrolase; autism spectrum disorder; Binding; biochemical tools; Biochemistry; Bioinformatics; Biology; Brain; brain circuitry; brain tissue; Chromatin; chromatin remodeling; Chromosome 6; Chromosomes; Data; Development; Dimensions; DNA; DNA Methylation; Embryo; Enhancers; Epigenetic Process; epigenetic regulation; Epilepsy; Fluorescent in Situ Hybridization; Gene Expression; Gene Expression Regulation; Gene Targeting; Genes; Genetic; Genetic Models; Genetic Transcription; genome-wide; Grant; Heart; Histone Acetylation; histone modification; Individual; Institutes; Intellectual functioning disability; Interneuron function; Interneurons; Link; Mass Spectrum Analysis; member; Molecular; Molecular Conformation; mouse genetics; Mus; neuropsychiatric disorder; next generation; novel; Nucleic acid sequencing; Nucleosomes; Peptide Sequence Determination; Play; Positioning Attribute; Proteins; recruit; Regulation; Regulator Genes; Reporting; Ribonucleoproteins; RNA; Role; Schizophrenia; Signal Transduction; Site; Sleep; SMARCA4 gene; System; Technology; three dimensional structure; Transcript; transcription factor; Transcriptional Regulation; Transgenes; Untranslated RNA; Work; ","Mechanisms regulating lncRNA short and long range signaling","111267","ZRG1","Special Emphasis Panel ","","","04","377686","148471","526157",""
"9850850","I01","VA","5","N","05/22/2020","01/01/2020","12/31/2020","999","I01BX004121","","RFA-BX-18-001","5I01BX004121-02","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","CLEVELAND","UNITED STATES","","14","093016124","US","481118","LOUIS STOKES CLEVELAND VA MEDICAL CENTER","OH","441413204","RELEVANCE: The Veteran (VA) population is at increased risk of developing lung cancer as compared to the general population because of higher smoking rates and increased likelihood of exposure to other carcinogens during their military service. The VA system cares for some 6.7 million mostly older male veterans each year, many of whom have long smoking histories. In a recent study, investigators from eight VA centers across the U.S. screened more than 2,000 Veterans over two years and found that only 2.5% of all suspicious nodules identified on chest CT scans were actually malignant. This high false positive rate results in a number of unnecessary repeat CT scans and surgical interventions (biopsy, bronchoscopy, wedge resections) for patients with benign nodules. In this project we seek to develop, optimize, validate and deploy an advanced Lung Image based Risk Score (LunIRiS) decision support tool for significantly improving the diagnostic evaluation of suspicious nodules on screening chest CT scans in the VA population. 1","8352708; ","MADABHUSHI, ANANT ;","","01/01/2019","12/31/2022","3-Dimensional; Adopted; Anxiety; Architecture; Area; base; Benign; Biopsy; Blood Vessels; Bronchoscopy; Cancerous; Carcinogens; care systems; Chest; chest computed tomography; Clinical; Clinical Trials; Clinics and Hospitals; cohort; computed tomography screening; Computer software; Computer-Assisted Diagnosis; computerized; cost; Data; Detection; Diagnosis; Diagnostic; diagnostic accuracy; Discrimination; disorder prevention; Dose; Evaluation; Excision; Exposure to; follow-up; General Population; Glean; Health Promotion; Human; Image; Image Analysis; imaging biomarker; improved; innovation; learning classifier; Lung; lung cancer screening; Lung CAT Scan; lung imaging; Lung nodule; Machine Learning; male; Malignant - descriptor; Malignant neoplasm of lung; Malignant Neoplasms; Measurement; Medicare; Military Personnel; Morbidity - disease rate; Morphology; Nodule; novel; Operative Surgical Procedures; Outcome; Patients; Pattern; Pattern Recognition; Phenotype; Population; programs; radiologist; radiomics; Reader; Research Personnel; Risk; ROC Curve; Role; routine screening; Scanning; screening; Services; Shapes; Smoke; Smoking; Smoking History; Specificity; success; support tools; Technology; Texture; tool; tumor; United States Department of Veterans Affairs; University Hospitals; Validation; Veterans; Visual; X-Ray Computed Tomography; ","Lung Imaging based Risk Score (LunIRIS): Decision support tool for screening CT","004121","ZRD1","Special Emphasis Panel ","","","02","","","",""
"10055934","UM1","CA","2","N","05/22/2020","05/22/2020","03/31/2021","395","UM1CA081457","","RFA-CA-19-059","2UM1CA081457-21","NCI:4395266\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","MEMPHIS","UNITED STATES","","09","067717892","US","7893501","ST. JUDE CHILDREN'S RESEARCH HOSPITAL","TN","381053678","PBTC Project Narrative The Pediatric Brain Tumor Consortium (PBTC) conducts novel and innovative clinical trials for Pediatric Central Nervous System (CNS) malignancies that incorporate correlative biology, genomics, pharmacology and sophisticated imaging techniques to advance the understanding of high-risk and recurrent pediatric brain tumors. PBTC trials are designed to define appropriate dosing, describe pediatric-specific toxicities and tumor biology as well as to identify early signals of efficacy, thereby directly impacting future prognostication and treatment strategies. It is only through this continued prospective and systematic drug development via early phase clinical trials that the overarching goal of achieving longer, healthier lives with less morbidity can ultimately be realized for children with CNS tumors.","1938888; 8820210 (contact); ","DUNKEL, IRA J; ONAR-THOMAS, ARZU  (contact);","SMITH, MALCOLM M","04/01/1999","03/31/2025","Adult; Adverse event; anticancer research; appropriate dose; Area; base; Basic Science; Biological; Biology; Biometry; Biotechnology; BRAF gene; Brain Neoplasms; Cancer Therapy Evaluation Program; Cancer Vaccines; Central Nervous System Neoplasms; Cessation of life; Child; Childhood; Childhood Brain Neoplasm; Childhood Central Nervous System Neoplasm; Clinical; Clinical Trials; Collaborations; Committee Members; Contracts; Convection; Data; data acquisition; data management; Development; Diagnosis; Diffuse intrinsic pontine glioma; drug development; Eligibility Determination; Ependymoma; epigenomics; experience; Focused Ultrasound; Future; Genomics; Geography; Glioma; Goals; high risk; Image; Imaging Techniques; Immune checkpoint inhibitor; Immunologics; Immunotherapeutic agent; Immunotherapy; improved; Infant; innovation; Institution; Intervention; Intrinsic factor; Laboratories; Laboratory Study; Lead; Local Therapy; Magnetic Resonance Imaging; Malignant Neoplasms; MAP Kinase Gene; Measures; Mediation; medulloblastoma; member; Mission; Modality; Molecular Target; Monitor; Morbidity - disease rate; mortality; multidisciplinary; Mutation; National Cancer Institute; Neuraxis; neuroimaging; neuropathology; Neurosurgeon; novel; novel strategies; Oncologist; Oncolytic viruses; operation; Pathway interactions; Pediatric Brain Tumor Consortium; Pediatric Neoplasm; Pediatric Oncology Group; pediatric patients; Pediatrics; Pharmaceutical Preparations; pharmacokinetics and pharmacodynamics; Pharmacologic Substance; Pharmacology; Phase; phase 2 study; Phase I Clinical Trials; Phase II Clinical Trials; prognostic; Prognostic Factor; programs; prospective; protocol development; quality assurance; Quality of life; Radiation Oncologist; Radiation Oncology; Recurrence; Refractory; Research; research clinical testing; Research Design; Research Personnel; response; Safety; Saint Jude Children's Research Hospital; Science; scientific organization; Series; Signal Transduction; Site; Solid Neoplasm; Structure; success; survival outcome; System; targeted agent; Therapeutic; Tissues; Toxic effect; Translating; translational clinical trial; Translational Research; translational scientist; Treatment Failure; treatment response; treatment strategy; trial design; tumor; Tumor Biology; working group; ","Pediatric Brain Tumor ConsortiumA multi-institutional consortium devoted to novel phase I and II clinical evaluations of experimental treatment approaches for pediatric CNS tumors.","081457","ZCA1","Special Emphasis Panel ","","","21","3290575","1104691","4395266",""
"9930454","T32","HD","5","N","05/20/2020","05/01/2020","04/30/2021","865","T32HD087969","","RFA-HD-16-015","5T32HD087969-05","NICHD:124804\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","WASHINGTON","UNITED STATES","","98","143983562","US","1518602","CHILDREN'S RESEARCH INSTITUTE","DC","200102916","PUBLIC HEALTH RELEVANCE: The relevance of this postdoctoral T32 training program at CNMC, in close collaboration with the FDA, Johns Hopkins University School of Medicine and the University of Maryland School of Pharmacy, is to train the next generation of pediatric clinical pharmacologists who will perform translational, regulatory and clinical research into all aspects of drug development and use in neonates, infants, children and adolescents. This T32 application responds to the absolute need to provide 2 years of training and experience under the direction of an experienced clinical pharmacologist. Ultimately this will result in more safe and effective use of medicines in children of all ages.","6697720; ","VAN DEN ANKER, JOHANNES NICOLAAS;","PAWLYK, AARON C","05/01/2016","04/30/2021","Childhood; Clinical Pharmacology; post-doctoral training; ","Postdoctoral training in Pediatric Clinical Pharmacology","087969","ZHD1","Special Emphasis Panel ","","","05","139852","10468","124804",""
"10145509","U19","AI","3","N","05/19/2020","05/19/2020","07/31/2020","855","U19AI128913","SCHOOLS OF MEDICINE","PA-18-591","3U19AI128913-03S2","NIAID:222841\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","PATHOLOGY","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","PROJECT NARRATIVE Characterization of the immune response to SARS-CoV-2 virus using a set of high-throughput CORE technologies, epigenetics, immune function assays and novel statistical and computational approaches will permit us to advance the field by describing immunologic characteristics that are associated with COVID-19 disease. We will also determine immune correlates of COVID-19 disease severity as reflected by measures of critical illness.","1867400 (contact); 7748143; ","REED, ELAINE F (contact); SARWAL, MINNIE M;","ROBIEN, MARK ANDREW","05/19/2020","07/31/2021","2019-nCoV; antigen-specific T cells; antiviral immunity; base; Biological Assay; Biometry; Cessation of life; Characteristics; Clinical; clinical phenotype; Clonality; Computer Models; Coupled; COVID-19; Critical Illness; Cytomegalovirus; Data; Development; Disease; DNA Methylation; Epigenetic Process; experience; Frequencies; Immune; immune function; Immune response; Immunologics; Immunology; Infection; Intubation; Kidney Transplantation; Measures; Mechanics; Morbidity - disease rate; mortality; novel; novel diagnostics; Outcome; Patients; Pneumonia; prevent; Resources; respiratory; Respiratory Failure; Respiratory Signs and Symptoms; Severity of illness; Syndrome; System; T-cell receptor repertoire; Technology; Therapeutic; Time; Transplant Recipients; Upper Respiratory Infections; Viral Antigens; Virus; Virus Diseases; ","Mapping Immune Responses to CMV in Renal Transplant Recipients - Mechanistic Assays Core","128913","","","","S2","03","142847","79994","222841",""
"9918116","P30","ES","1","N","05/21/2020","05/15/2020","03/31/2021","","P30ES030284","","RFA-ES-18-003","1P30ES030284-01A1","NIEHS:184601\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","10129249; ","LAIRD, DIANA J;","","05/22/2020","03/31/2025","Address; Area; Award; base; Basic Science; Biomedical Research; California; career; career development; Clinical; Clinical Research; Collaborations; Communities; Community Health; Core Facility; Development; Ensure; Environmental Health; Epidemiology; epidemiology study; Evaluation; experience; Faculty; Feedback; Fostering; Funding; Funding Opportunities; Future; Goals; Grant; Health; innovation; Institution; interdisciplinary approach; Interdisciplinary Study; Link; member; Mentors; Mentorship; Mission; multidisciplinary; National Institute of Environmental Health Sciences; next generation; novel; Outcome; Pilot Projects; Planet Earth; Population; Process; Professional Practice; programs; Reporting; Reproduction; Request for Applications; Research; Research Personnel; Research Project Grants; Resource Allocation; Resources; San Francisco; Scientist; Seeds; Site; skill acquisition; success; Time; Transferable Skills; Translational Research; Translations; United States National Institutes of Health; Universities; Work; ","Pilot Project Program","030284","EHS","Environmental Health Sciences Review Committee ","7076","A1","01","114423","70178","","184601"
"9930685","R01","NS","5","N","05/20/2020","05/01/2020","04/30/2021","853","R01NS108376","","PA-16-160","5R01NS108376-09","NINDS:608525\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","MEMPHIS","UNITED STATES","","09","067717892","US","7893501","ST. JUDE CHILDREN'S RESEARCH HOSPITAL","TN","381053678","PROJECT NARRATIVE GAA triplet repeat expansions silence Frataxin (FXN) gene expression and result in the neurodegenerative Friedreich's ataxia. A novel class of molecules, Syn-TEFs, target GAA repeats and restore FXN synthesis. This proposal aims to elucidate the mechanism by which Syn-TEFs overcome the silencing of FXN.","7376805; ","ANSARI, ASEEM Z;","GUBITZ, AMELIE","07/01/2018","04/30/2023","Adopted; Afferent Neurons; Antisense Oligonucleotides; Ataxia; Attenuated; B-DNA; base; Cardiac Myocytes; Cell Line; cell type; Cells; chemical genetics; Chromatin; Consensus; Cytosine; design; Development; Diabetes Mellitus; Disease; DNA; DNA Methylation; DNA Polymerase II; DNA Structure; DNA-Directed RNA Polymerase; effective therapy; Epigenetic Process; Evaluation; Fragile X Syndrome; frataxin; Friedreich Ataxia; Gene Expression; Gene Silencing; Generations; Genes; Genetic Transcription; Genome; Heterochromatin; Histone Deacetylase Inhibitor; histone modification; Histones; Hybrids; Hypertrophic Cardiomyopathy; Incidence; Individual; induced pluripotent stem cell; Inherited; innovation; insight; Introns; Investigation; iron metabolism; Lead; Maps; Messenger RNA; Microsatellite Repeats; Mitochondria; Modeling; Morbidity - disease rate; Nerve Degeneration; Neurodegenerative Disorders; next generation; novel; Nuclear; Nylons; Patients; Pattern; Play; Pluripotent Stem Cells; Precision therapeutics; prevent; progressive neurodegeneration; Protein Deficiency; Proteins; recruit; Reporting; restoration; RNA; RNA chemical synthesis; Role; Specificity; Symptoms; Syndrome; synergism; Testing; tool; Transcription Elongation; Transcriptional Elongation Factors; transcriptome; Trinucleotide Repeats; triplex DNA; ","Synthetic molecules to stimulate the expression of Frataxin to ameliorate Freidreichs Ataxin","108376","MNG","Molecular Neurogenetics Study Section ","","","09","339011","269514","608525",""
"9865717","R01","DK","1","N","05/14/2020","05/18/2020","04/30/2021","847","R01DK123144","SCHOOLS OF MEDICINE","PA-19-056","1R01DK123144-01","NIDDK:439714\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NEW ORLEANS","UNITED STATES","PHYSIOLOGY","01","053785812","US","8424601","TULANE UNIVERSITY OF LOUISIANA","LA","701185665","PROJECT NARRATIVE High blood pressure affects over 46% of the United States? adult population, and if left untreated, it will lead to heart failure, stroke, and end-stage kidney diseases. This project uses highly innovative proximal tubule-selective, genetically modified animal models and novel pharmacological approaches to identify intratubular and intracellular angiotensin II and its AT1 (AT1a) receptors in the proximal tubules of the kidney as a novel mechanism and therapeutic targets of hypertension and kidney injury. This new knowledge will help develop new proximal tubule-targeting drugs to treat uncontrolled hypertension and kidney injury in humans.","7739524; ","ZHUO, JIA L.;","KETCHUM, CHRISTIAN J","05/18/2020","04/30/2024","adenoviral-mediated; Adult; Affect; Angiotensin II; Angiotensinogen; Animal Model; Antihypertensive Agents; antiporter; Attenuated; Biological Assay; Blood Pressure; blood pressure regulation; Cardiovascular Diseases; cardiovascular injury; cardiovascular risk factor; Cardiovascular system; CCL2 gene; Cells; chemokine; clinically relevant; Clip; Cre-LoxP; cytokine; Data; Development; Down-Regulation; Drug Targeting; Elastin; Electrons; End stage renal failure; extracellular; Fluorescein-5-isothiocyanate; Genes; Genetic Transcription; Genetically Modified Animals; Glomerular Filtration Rate; Glucose; Heart failure; Human; Hypertension; Image; Impairment; Infusion procedures; Injury to Kidney; innovation; Kidney; Kidney Failure; Knock-out; Knockout Mice; Knowledge; Left; Liver; Measurement; Measures; Microscopic; microscopic imaging; Mitochondria; mitochondrial dysfunction; Mitochondrial Proteins; Monitor; mouse model; multi-photon; Natriuresis; novel; organ injury; overexpression; Pathogenesis; Pathway interactions; patient response; Patients; Pharmacology; Play; polypeptide; Population; pressure; Proteins; Proteomics; Proximal Kidney Tubules; receptor; Receptor Gene; Regulation; Renal Hypertension; renal ischemia; Reperfusion Injury; response; Reverse Transcriptase Polymerase Chain Reaction; Role; Signal Transduction; Signaling Protein; Sirtuins; Small Intestines; Stroke; symporter; Telemetry; Testing; therapeutic target; Time; Tissues; TLR4 gene; Tubular formation; two-photon; United States; Western Blotting; ","Intratubular Angiotensin II and AT1a Receptors in The Proximal Tubules: Roles in Hypertension and Kidney Injury","123144","HM","Hypertension and Microcirculation Study Section ","","","01","289524","150190","439714",""
"10028560","R01","MH","3","N","05/18/2020","01/06/2020","10/31/2020","242","R01MH112681","","PA-18-591","3R01MH112681-04S1","NIMH:42525\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","LA JOLLA","UNITED STATES","","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","Narrative Binge-eating is a behavioral characteristic of bulimia nervosa and binge eating disorder and associated with significant morbidity and mortality, but its neurobiological underpinnings are not well understood. This project will identify the impact of negative affect on brain circuitry for dopamine related reinforcement learning, food value computation and cognitive control over food choice across individuals with bulimia nervosa, binge eating disorder, obesity and healthy controls. This project will provide information on specific brain circuit alterations that drive binge- eating as well as directions for future treatment development.","8051216; ","FRANK, GUIDO KW;","CHAVEZ, MARK","12/26/2017","10/31/2022","Affect; Affective; Age; base; Base of the Brain; Behavior; Behavioral; behavioral study; Binge Eating; Binge eating disorder; Biological; Brain; brain circuitry; Brain imaging; brain research; Brain scan; Bulimia; Calories; Categories; Characteristics; Cognition; Cognitive; cognitive control; Computer Models; Control Groups; Corpus striatum structure; Depressed mood; Diagnostic; Disease; Distress; Dopamine; dopamine system; Eating; Eating Disorders; Ecological momentary assessment; Emotions; Environment; Exanthema; Feeling; Food; Future; Health; healthy weight; Individual; Insula of Reil; Intervention; Knowledge; Learning; Link; Magnetic Resonance; Measures; mind control; Morbidity - disease rate; mortality; Motivation; National Institute of Mental Health; negative affect; Neurobiology; Neurosciences; Neurotransmitters; Obesity; Persons; Positive Valence; Prefrontal Cortex; Psychological reinforcement; psychopharmacologic; Quality of life; Randomized; Recurrence; Regulation; relating to nervous system; Reproducibility; Research; Research Domain Criteria; response; reward processing; Rewards; Scanning; sex; Symptoms; System; Taste Perception; Testing; therapy development; Ventral Striatum; Vomiting; Weight; ","Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes","112681","APDA","Adult Psychopathology and Disorders of Aging Study Section ","","S1","04","27000","15525","42525",""
"10008093","R43","HL","1","N","05/20/2020","05/20/2020","04/30/2021","838","R43HL152825","","PA-19-272","1R43HL152825-01","NHLBI:291369\","SBIR-STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","SAINT PAUL","UNITED STATES","","04","621641237","US","10010779","MINNESOTA HEALTHSOLUTIONS CORPORATION","MN","551053031","Project Narrative The proposed project seeks to develop and validate a software system that can use routine pulmonary CT angiograms to guide pulmonary embolism treatment decisions. Pulmonary embolism is the third most common cause of death in hospital patients with an estimated incidence of 1 per 1,000 patients. A successful completion of this project would provide a tool capable of faster PE detection and more accurate staging of right heart strain to guide the physician?s treatment decision.","9760160; ","CHAMBERLAIN, RYAN M;","FESSEL, JOSHUA P","05/20/2020","04/30/2021","Accident and Emergency department; Accounting; Acute; Angiography; Area; Artificial Intelligence; case control; Cause of Death; Cessation of life; Chest; Clinical; clinical biomarkers; Cohort Studies; Computer software; convolutional neural network; Data; deep learning; Detection; Diagnostic; Epidemiology; Europe; Functional disorder; Future; Goals; Heart; high risk; Hospitals; Image Analysis; improved; Incidence; learning strategy; Lung; Machine Learning; Manuals; Measurement; Measures; Medical; Medical Imaging; Minnesota; Modeling; Neural Network Simulation; Patient Care; Patients; Performance; Phase; Physicians; prototype; Pulmonary Embolism; radiologist; Radiology Specialty; Reader; Reporting; research and development; Right ventricular structure; software systems; Software Tools; Speed; Staging; System; Technology; technology development; Time; tool; Training; validation studies; X-Ray Computed Tomography; ","Automated acute pulmonary embolism detection and staging from CT","152825","ZRG1","Special Emphasis Panel ","","","01","","","291369",""
"9894543","R21","ES","1","N","05/18/2020","05/19/2020","04/30/2021","113","R21ES030142","","PA-19-053","1R21ES030142-01A1","NIEHS:286490\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","RESEARCH TRIANGLE PARK","UNITED STATES","","04","004868105","US","6939101","RESEARCH TRIANGLE INSTITUTE","NC","277092194","PROJECT NARRATIVE This proposed study aims to improve the exposure assessment methodology for robust studies that examine ultrafine particulate matter's (PM's) distinctive effects on lung function impairment by applying inhaled dose from novel exposure assessment approaches enabled by our innovative integration of wearable PM sensors, biometric sensors, and an ecological momentary assessment tool. This proposed effort will form the foundation of future advanced environmental health epidemiological studies by informing of the study design and approaches to produce robust exposure data of ultrafine PM with PM2.5 and other co-pollutants and providing preliminary data regarding the distinct and joint effects of varying size fractions of PM and other pollutants on lung function.","12492027 (contact); 9369171; ","CHO, SEUNG-HYUN  (contact); RYAN, PATRICK H;","CUI, YUXIA","05/19/2020","04/30/2022","Accelerometer; Address; Adolescent; Adverse effects; Affect; Air; air monitoring; Air Pollutants; Air Pollution; Alveolar; Area; Assessment tool; Asthma; asthmatic; Biometry; Caliber; Carbon Black; Child; Childhood Asthma; Clinical; Data; Data Collection; data infrastructure; Data Set; Deposition; Dose; Ecological momentary assessment; Environment; Environmental air flow; Environmental Health; Epidemiology; epidemiology study; Evaluation; Exposure to; fine particles; Foundations; Future; Global Positioning System; Health; Health Policy; Impairment; improved; Individual; Inhalation; innovation; insight; Institutes; Intake; Intervention; Joints; Knowledge; Link; Location; Lung; Measurement; Measures; Metals; Methodology; Methods; mHealth; miniaturize; Modeling; Monitor; nanometer; Nitrogen Dioxide; novel; Outcome; Ozone; Participant; particle; particle exposure; Particulate Matter; Pattern; Persons; Physiological Processes; Play; pollutant; Proxy; Reactive Oxygen Species; Research; Research Design; respiratory; respiratory health; Respiratory physiology; response; Risk; Role; sensor; Site; Source; spatiotemporal; Surface; Technology; theories; Time; tool; Toxic effect; toxicant; Toxicology; Translating; Ultrafine; ultrafine particle; Work; ","Innovative Personal Monitoring Approaches to Characterize Ultrafine and Fine Particulate Matter and Respiratory Health Effects","030142","IRAP","Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section ","","A1","01","186696","99794","286490",""
"9927926","K23","HL","5","N","05/20/2020","05/01/2020","04/30/2021","839","K23HL138261","SCHOOLS OF MEDICINE","PA-16-198","5K23HL138261-03","NHLBI:170639\","OTHER RESEARCH-RELATED","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","Aurora","UNITED STATES","INTERNAL MEDICINE/MEDICINE","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","PROJECT NARRATIVE Pain impacts more than 100 million Americans annually, including a large majority of persons with hemophilia, resulting in significant disability, loss of productivity, and reduced quality of life. The current lack of established methods for assessing and monitoring pain as a standard component of hemophilia clinical care severely limits clinicians' abilities to understand pain's impact on physical, social, and emotional function, assess responses to treatment, and monitor long-term outcomes of prevention strategies. Completing the aims of this study will contribute to the NIH mission to apply scientific knowledge to enhance health and reduce disability through improved assessment of pain in persons with hemophilia, which will ultimately lead to more effective pain management in individuals with this chronic disease.","10922579; ","BUCKNER, TYLER WAYNE;","MARTIN, IMAN","05/15/2018","04/30/2023","Acute Pain; Address; Adult; Affect; Age; American; Americas; arthropathies; Asthma; Behavior; Biological Models; Blood Coagulation Disorders; Blood Coagulation Factor; Brief Pain Inventory; career; career development; Caring; Chronic; Chronic Disease; chronic pain; Clinic; Clinical; clinical care; clinical practice; Clinical Research; cognitive interview; Colorado; Communities; computerized; Cross-Sectional Studies; daily pain; Data Collection; design; Diabetes Mellitus; diagnosis evaluation; disability; Disease; Emotional; Environment; Event; experience; Faculty; Floor; Future; General Population; Generations; Goals; Health; Health Personnel; Hemophilia A; Hemorrhage; High Prevalence; Home environment; Hour; implementation science; improved; Individual; Information Systems; Inherited; innovation; Institute of Medicine (U.S.); Intention; Intervention; Joints; Knowledge; Lead; Life; longitudinal analysis; longitudinal design; Longitudinal Studies; male; Measurement; Measures; member; men; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Mission; Monitor; Muscle; named group; novel strategies; Outcome; Outcome Assessment; Outcome Measure; Outcomes Research; Pain; Pain intensity; Pain management; Pain Measurement; pain relief; pain score; Patient Outcomes Assessments; Patients; Persons; Play; Population; Prevention strategy; Problem Solving; Procedures; productivity loss; Proteins; Psychometrics; Quality of life; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; research study; Research Training; Resolution; response; Role; Science; Self Management; SF-36; skills; social; Testing; Time; Time Study; Training; training opportunity; Trauma; treatment center; treatment response; United States National Institutes of Health; Universities; Validity and Reliability; ","Testing and Implementation of the Patient-Reported Outcomes Measurement Information System Measures of Pain Intensity, Interference, and Behavior in Routine Clinical Care of Persons with Hemophilia.","138261","MPOR","NHLBI Mentored Patient-Oriented Research Review Committee ","","","03","157999","12640","170639",""
"10040848","R21","AI","1","N","05/21/2020","05/22/2020","04/30/2021","855","R21AI153867","","PA-19-053","1R21AI153867-01","NIAID:274500\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LA JOLLA","UNITED STATES","","52","603880287","US","2465301","LA JOLLA INSTITUTE FOR IMMUNOLOGY","CA","920371387","Project Narrative The prevalence of asthma and allergic diseases has been increasing for the last several decades. Fifteen million patients suffer from asthma in the US alone. However, no treatment is preventive or curative. IgE and mast cells play a central role in the pathogenesis of asthma and allergic diseases. Respiratory virus infection- induced acute exacerbations of asthma represent severe morbidity, mortality, and burdensome healthcare costs. Thus, better understanding of asthma exacerbations is urgently needed to develop novel therapeutic and preventive strategies. Our preliminary data demonstrates that anti-viral signaling molecule MAVS inhibits Syk, the key signaling protein for allergen/IgE-induced mast cell activation. This project will reveal not only a novel aspect of Syk regulation, but also a new paradigm of asthma exacerbation pathogenesis and its cellular and molecular basis. Therefore, this project will provide novel insight into novel innovative therapeutic strategies.!","1891694; ","KAWAKAMI, TOSHIAKI ;","DONG, GANG","05/22/2020","04/30/2022","activating transcription factor; Acute; Adaptor Signaling Protein; Affinity; Allergens; Allergic Disease; Allergic Reaction; Antigens; Antiviral Agents; Asthma; asthma exacerbation; base; Basophils; Binding; Cell Density; Cells; chemokine; crosslink; cysteinyl-leukotriene; cytokine; Cytokine Gene; Cytoplasm; Data; Disulfides; Double-Stranded RNA; Eicosanoids; Enzymes; Event; experimental study; Family; Genes; Genetic Transcription; Genetically Engineered Mouse; Health Care Costs; Histamine Production; Histamine Release; i(19); IgE; IgE Receptors; In Vitro; in vivo; Infection; Inflammatory; Influenza A virus; influenzavirus; innovation; insight; Interferon Type I; Interleukin-13; Interleukin-4; IRF3 gene; ITAM; LCP2 gene; Ligands; Link; Lung Inflammation; MAP Kinase Gene; mast cell; Mast Cell Stabilizer; Mediating; Mediator of activation protein; melanoma; Mitochondria; Molecular; Morbidity - disease rate; mortality; Mus; NF-kappa B; novel; novel therapeutics; Outer Mitochondrial Membrane; Passive Cutaneous Anaphylaxis; pathogen; Pathogenesis; Pathway interactions; Patients; Pattern recognition receptor; Peptide Hydrolases; Pharmacology; Phase; phospholipase C gamma; Phosphoric Monoester Hydrolases; Phosphorylation; Play; Prevalence; prevent; Prevention strategy; Preventive; Preventive Intervention; prion-like; Production; Prostaglandins; Protein Family; Protein Tyrosine Kinase; Protein Tyrosine Phosphatase; PTPN6 gene; Pulmonary Pathology; receptor; Receptor Signaling; recruit; Regulation; respiratory infection virus; Respiratory System; respiratory virus; response; RNA; RNA Helicase; RNA Viruses; Role; Signal Pathway; Signal Transduction; Signaling Molecule; Signaling Protein; src Homology Region 2 Domain; src-Family Kinases; Structure; T-Lymphocyte; TBK1 gene; Therapeutic; TLR3 gene; TLR7 gene; TNF gene; Toll-like receptors; transcription factor; Transcriptional Activation; Tretinoin; Tyrosine; Tyrosine Phosphorylation; Ubiquitin; Virus Diseases; ","Crosstalk between FceRI and MAVS signaling pathways in mast cells","153867","ZRG1","Special Emphasis Panel ","","","01","150000","124500","274500",""
"9854039","U54","AG","1","N","05/20/2020","09/01/2019","08/31/2020","","U54AG062322","","RFA-OD-19-013","1U54AG062322-01A1","NIA:421547\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE ON AGING","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","NARRATIVE Hot flashes and night sweats, or vasomotor symptoms (VMS), affect up to 85% of postmenopausal women, persist 10 or more years in 33?40% of postmenopausal women, and are strongly liked with stress, which exerts its effects through the brain. Understanding biological mechanisms underlying VMS occurrence and persistence will have significant public health impact because VMS affect so many women, have a negative impact on quality of life, and are associated with sleep disruption and cardiometabolic disease, which increase susceptibility to dementia in aging women. As part of the Brigham/Harvard Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes, this study will advance the health of postmenopausal women by determining stress responses, neural processes, and neurobiological mechanisms that are affected when VMS occur and persist.","6684491; ","JOFFE, HADINE ;","","","","Acute; acute stress; Adrenal Cortex Hormones; Affect; Aging; Anterior; Anxiety; Autonomic nervous system; base; Behavior Therapy; Biological; biological adaptation to stress; Brain; Brain region; cardiometabolism; Cardiovascular Diseases; career; Chronic stress; cingulate cortex; cohort; common symptom; comorbidity; Data; Dementia; Disease; Dynorphins; Educational process of instructing; Enrollment; Exhibits; Faculty; follow-up; Functional Magnetic Resonance Imaging; gamma-Aminobutyric Acid; Goals; Health; High Prevalence; Hippocampus (Brain); hormone therapy; Hot flushes; hypothalamic-pituitary-adrenal axis; improved; innovation; Insula of Reil; Intervention; Investigation; KISS1 gene; Link; Magnetic Resonance Spectroscopy; Measures; Mediating; Menopause; Mental Depression; Mentors; Metabolic Diseases; Methodology; neural network; neurobiological mechanism; Neurons; Neurophysiology - biologic function; neuroregulation; Neurotransmitters; Night Sweating; novel; Outcome; Outcome Study; Pain; Participant; Pathway interactions; perceived stress; Play; Postmenopause; Predisposition; Prevention; Process; Psychosocial Stress; Public Health; Quality of life; relating to nervous system; reproductive senescence; Resources; response; Risk; Role; Sleep; Sleep disturbances; Stress; Symptoms; targeted treatment; Testing; Vasomotor; Woman; ","Stress response and neural network function in women with vasomotor symptoms","062322","ZRG1","Special Emphasis Panel ","7958","A1","01","268971","152576","","421547"
"9868921","R01","CA","7","N","05/18/2020","03/01/2020","02/28/2021","395","R01CA211648","SCHOOLS OF MEDICINE","PA-16-160","7R01CA211648-04","NCI:411369\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","CHICAGO","UNITED STATES","PEDIATRICS","07","005436803","US","6144650","NORTHWESTERN UNIVERSITY AT CHICAGO","IL","606113152","NARRATIVE The overall goal of our research has focused on understanding the genetic and epigenetic basis of chemo-resistance in ovarian cancer. Ovarian cancer is associated with the worst survival of all gynecological cancers. Although the vast majority of ovarian cancers are initially chemo-sensitive, with a 70-80% response rate, the recurrence and progression due to chemo-resistance is nearly ubiquitous. Identifying the key drivers of chemo-resistance, which is the single major cause of high mortality rate of this disease, remains a major gap in our knowledge. Our in preliminary results support the hypothesis that aberrant regulation at distal regulatory sites in the genome called enhancers drive the expression of key genes that mediate chemo resistance in ovarian cancer. In this proposal, we will use clinically relevant in vivo models to assess a novel therapeutic approach to target and inhibit the acquired chemoresistance and get mechanistic understanding on the role of chemotherapy induced aberrant gene expression in driving chemoresistance in high grade serous ovarian cancer.","11132085; ","ADLI, MAZHAR ;","VENKATACHALAM, SUNDARESAN","03/01/2017","02/28/2022","Automobile Driving; base; Biology; cancer cell; Cell Line; Cells; chemotherapy; ChIP-seq; Chromatin; Cisplatin; Clinical; clinically relevant; Clustered Regularly Interspaced Short Palindromic Repeats; combinatorial; Cues; Data; Development; Disease; Distal; Enhancers; Epigenetic Process; epigenome; epigenomics; Expression Profiling; Gene Expression; Gene Targeting; Genes; Genetic; Genetic Enhancer Element; Genetic Transcription; Genome; Genomic Segment; Goals; improved; In Vitro; in vivo; in vivo Model; inhibitor/antagonist; innovation; Knock-out; Knowledge; Lead; Malignant Female Reproductive System Neoplasm; Malignant neoplasm of ovary; Malignant Neoplasms; Maps; Mediating; mortality; new therapeutic target; novel strategies; novel therapeutic intervention; Outcome; Ovarian; Patients; Pharmacology; Phenotype; Platinum; Process; programs; promoter; Recurrence; Regulation; Research; Resistance; resistance gene; response; Role; Sampling; Serous; Site; small molecule; System; targeted biomarker; Testing; Therapeutic; Time; transcription factor; transcriptome; transcriptome sequencing; Treatment Efficacy; tumor; tumor growth; Work; Xenograft Model; Xenograft procedure; ","Identifying the Drivers and Targeting Chemo Resistance in Ovarian Cancer","211648","CAMP","Cancer Molecular Pathobiology Study Section ","","","04","266038","145331","411369",""
"9916742","U10","CA","5","N","05/18/2020","03/01/2020","02/28/2021","","U10CA180868","","RFA-CA-17-056","5U10CA180868-07","NCI:3793868\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","PHILADELPHIA","UNITED STATES","","03","078695317","US","10033231","NRG ONCOLOGY FOUNDATION, INC.","PA","191032800","","1873940; ","WOLMARK, NORMAN ;","","","","Address; Adult; Advisory Committees; Cancer Patient; Clinical; Clinical Oncology; Clinical Trials; cohort; Collaborations; data management; Development; experience; Fostering; Goals; improved; Infrastructure; Lead; Leadership; member; Mentors; Mission; Modeling; Modernization; Monitor; oncology; operation; organizational structure; Population; programs; Research; Site; statistics; success; ","NRG Oncology Network Group Operations Center","180868","ZCA1","Special Emphasis Panel ","7983","","07","4258429","134284","","3793868"
"9921435","P30","EY","5","N","05/20/2020","04/01/2020","03/31/2021","","P30EY008098","","PAR-17-322","5P30EY008098-32","NEI:158326\","RESEARCH CENTERS","2020","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","","1893838; ","KINCHINGTON, PAUL R.;","","","","Bioinformatics; Biological Assay; CLC Gene; Complex; Consult; Core Grant; Data; design; Development; DNA; education resources; Environment; Equipment; Evaluation; experience; Experimental Designs; Faculty; Gene Expression Profiling; Genomics; Learning; Libraries; Methodology; Methods; Mind; Molecular; molecular array; Molecular Biology; Molecular Evolution; nano-string; next generation; next generation sequencing; Pathway interactions; Preparation; programs; Quantitative Reverse Transcriptase PCR; Research Personnel; Research Project Grants; RNA; RNA analysis; Sampling; Services; Supercomputing; System; Techniques; Technology; tool; Training; transcriptomics; Universities; Viral; Vision; Vision research; vision science; ","Molecular Biology Core","008098","ZEY1","Special Emphasis Panel ","5951","","32","101167","57159","","158326"
"10137397","R44","AI","3","N","05/21/2020","05/21/2020","02/28/2021","855","R44AI109926","","PA-18-591","3R44AI109926-05S1","NIAID:476975\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ROCKVILLE","UNITED STATES","","06","965180610","US","10028042","SIGMOVIR BIOSYSTEMS, INC.","MD","208506330","The SARS-CoV-2 responsible for the Coronavirus disease 2019 (COVID-2019) outbreak represents a major public health threat that urgently requires development of a small animal model that can be used to test medical countermeasures. We will test whether the cotton rat model is a reliable small animal model for screening newly developed vaccines and therapeutics against SARS-CoV-2.","7035977; ","BLANCO, JORGE C;","KIM, SONNIE","05/21/2020","02/28/2021","2019-nCoV; Adult Respiratory Distress Syndrome; Animal Model; Animals; Binding; biosafety level 3 facility; Blood; chemokine; Clinical; Collaborations; Communicable Diseases; Cotton Rats; COVID-19; cytokine; Development; Disease; Disease Outbreaks; draining lymph node; efficacy testing; Enzyme-Linked Immunosorbent Assay; experience; Health; Histopathology; HMGB1 gene; Human; human model; Human Resources; Immune; Immune response; Inactivated Vaccines; Inbreeding; Infection; Investigational Therapies; Laboratories; Liver; Lung; medical countermeasure; Modeling; Monitor; Moths; Mus; neutralizing antibody; Nose; novel; novel vaccines; parent grant; Pathway interactions; Phase; Positioning Attribute; Predisposition; Preparation; prophylactic; Prophylactic treatment; Public Health; Quantitative Reverse Transcriptase PCR; Resources; respiratory; Respiratory Syncytial Virus Vaccines; Respiratory System; screening; Senior Scientist; Serologic tests; Serum; Sigmodon; Small Business Innovation Research Grant; Spleen; Testing; Therapeutic; therapeutic candidate; TLR4 gene; vaccination strategy; vaccine candidate; Vaccines; Viral; viral detection; Virus; Virus Diseases; Virus Replication; Work; ","Development of VLP vaccine for RSV","109926","","","","S1","05","","","476975",""
"9921227","U54","MD","5","N","05/18/2020","04/01/2020","03/31/2021","","U54MD010722","","RFA-MD-15-013","5U54MD010722-05","NIMHD:124091\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","8652214; ","GRIFFITH, DEREK M;","","","","20 year old; Adoption; Affect; African American; Age; age group; attentional control; Attitude; base; Behavior; Behavior Therapy; Behavioral; Belief; Biological; Biological Factors; Biology; Blood Glucose; Body fat; Body Weight decreased; Chronic Disease; Communities; comparative efficacy; Control Groups; Data; demographics; design; diabetes risk; Diet; Disease Outcome; disorder risk; Eating; Effectiveness; Effectiveness of Interventions; energy balance; Ethnic Origin; Etiology; Evaluation; experience; Focus Groups; Gender; Genetic; Glycosylated hemoglobin A; Goals; Health; Health behavior; Health Communication; Healthy Eating; Heterogeneity; improved; Individual; Internet; Intervention; Intervention Trial; Latina; Latino; Lipids; Maintenance; Measures; Mediator of activation protein; men; men's group; middle age; Monitor; Morbidity - disease rate; mortality; Motivation; Obesity; Outcome; Overweight; Pattern; personalized intervention; Persons; Phenotype; Physical activity; physical inactivity; Physiological; Pilot Projects; Play; population health; precision medicine; psychologic; psychosocial; Race; racial and ethnic; Randomized; Randomized Controlled Trials; Research; Resources; Risk; Risk Behaviors; Role; sedentary lifestyle; Self Efficacy; Shapes; social; Social support; Surface; Testing; Text; Training and Education; Treatment Efficacy; wearable device; Weight; weight loss intervention; Woman; Work; ","Project-3 Tailored behavioral intervention for overweight African Americans and Latino men","010722","ZMD1","Special Emphasis Panel ","8206","","05","96212","27879","","124091"
"10118080","I21","VA","5","N","05/22/2020","04/01/2020","03/31/2021","999","I21BX003815","","RFA-BX-17-005","5I21BX003815-03","","RESEARCH CENTERS","2020","Veterans Affairs","","EAST ORANGE","UNITED STATES","","10","087286308","US","10018809","VA NEW JERSEY HEALTH CARE SYSTEM","NJ","070181023","Volatile organic compounds (VOCs), including trichloroethylene (TCE) and tetrachloroethylene (PCE), were detected in multiple ground water sources at Camp Lejeune (CL) in the 1980s. It is estimated that they may have exceeded acceptable levels for 30 years. The contaminated water is now implicated in causing Parkinson's Disease (PD). However, toxicology studies involving the 2 primary VOCs detected in the CL water (TCE and PCE) had limited face validity to the actual exposures: dosages 100-1000 times that of the highest estimated human exposure levels; single daily administrations; and dosing periods no more that 6-8 weeks. This pilot program is an initial attempt to determine the likelihood that the water contamination caused PD in people stationed at CL by dosing rats chronically through their in drinking water and assessing their brain and behavior for signs of PD.","9464867; ","BECK, KEVIN D.;","","04/01/2018","03/31/2021","3-nitrotyrosine; Address; Affect; Aging; Animal Model; Area; Autopsy; base; Behavior; Behavior assessment; behavior test; Behavioral; Biological; Brain; brain behavior; brain tissue; Chronic; contaminated drinking water; contaminated water; Corpus striatum structure; Detection; Development; disease registry; Dopamine; dopaminergic neuron; Dorsal; dosage; Dose; drinking water; Exhibits; Experimental Designs; exposed human population; Exposure to; Face; Family; Goals; ground water; Gulf War; Harvest; Health; health assessment; Health Care Costs; High Pressure Liquid Chromatography; Individual; Ingestion; Knowledge; Longitudinal Studies; Measures; Medical; Medical center; Methods; Microglia; Modeling; Molecular Analysis; Motor; motor impairment; Nerve Degeneration; neurobehavioral; Neurodegenerative Disorders; neuroinflammation; Neurologic; Neurons; neuropathology; neurotoxic; neurotoxicity; nigrostriatal pathway; Nitrates; Ohio; Olive oil preparation; Oranges; Parkinson Disease; pars compacta; Pathology; Pilot Projects; Poison; Poisoning; Pollution; programs; Proteins; Public Health; Publishing; Rattus; Recording of previous events; Research; Research Design; Research Personnel; response; Rodent; Signal Transduction; Source; Stains; Stress; Substantia nigra structure; Testing; Tetrachloroethylene; Time; Tissues; Toxic effect; Toxicology; Trichloroethylene; Tyrosine 3-Monooxygenase; Universities; Veterans; volatile organic compound; Water; Water Supply; Work; ","Volatile organic compound effects on brain and behavior","003815","NURE","Neurobiology E ","","","03","","","",""
"10159106","I01","VA","5","N","05/17/2020","02/01/2020","01/31/2021","999","I01HX002035","","RFA-HX-16-005","5I01HX002035-04","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","INDIANAPOLIS","UNITED STATES","","07","608434697","US","481029","RLR VA MEDICAL CENTER","IN","462022803","Given the modest effectiveness of current treatments and the burden chronic neck pain places on veterans, our research proposal is significant in several regards. First, Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated (TOMCATT) Study directly addresses a high priority area for the VA and is well aligned with the VHA Pain Management Strategy and VHA Pain Management Directive 2009-053. Second, because previous massage studies have included relatively small sample sizes, our trial will provide information vital to fill an evidence vacuum regarding effectiveness of two different massage treatments for chronic neck pain. Third, TOMCATT will extend our current understanding of non-pharmacological treatments. Fourth, if the study hypotheses are corroborated massage may emerge as an effective, safe, affordable, sustainable, and accessible treatment for Veterans.","8623489; ","BAIR, MATTHEW JOHN;","","02/01/2017","08/31/2021","Address; Adherence; Ambulatory Care Facilities; Anxiety; Area; arm; Arthralgia; Back Pain; base; Books; Budgets; cancer care; Caregivers; Caring; chiropracty; Chronic; Chronic neck pain; chronic pain; Clinic; Clinical; Communities; community setting; Complementary Health; Complementary therapies; conventional therapy; Cost Savings; Data; disability; Effectiveness; eligible participant; Fatigue; Foundations; Geographic Locations; health related quality of life; Hour; improved; Individual; innovation; Intervention; intervention cost; Interview; Malignant Neoplasms; Massage; Medical; Medical center; Medication Management; Mental Depression; Methodology; Methods; Modeling; Neck Pain; Non-Steroidal Anti-Inflammatory Agents; novel; Opioid; Outcome; Pain; Pain intensity; Pain management; pain outcome; pain relief; Participant; Patients; Pharmaceutical Preparations; Physical therapy; practice setting; Prevalence; Primary Health Care; primary outcome; Public Health; Publishing; Quality of life; Randomized; Randomized Clinical Trials; recruit; Reporting; Research; Research Proposals; Risk; Role; Safety; Sample Size; Sampling; Sampling Studies; secondary outcome; Self Care; Severities; Standardization; Stress; Surveys; Testing; three-arm study; Time; Toxic effect; treatment arm; Uninsured Medical Expense; Vacuum; Veterans; Visit; Waiting Lists; Work; ","Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated (TOMCATT)","002035","HSR6","Blank ","","","04","","","",""
"9922349","R01","HL","5","N","05/22/2020","05/01/2020","04/30/2021","838","R01HL135849","","PA-16-160","5R01HL135849-04","NHLBI:511205\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","Project Narrative Acute respiratory distress syndrome (ARDS) is a common and life-threatening condition that is most frequently caused by sepsis, has a 30-50% death rate, and has no disease-specific therapies. Hemoglobin that has escaped from red blood cells is a potential proximal trigger for sepsis-induced ARDS and is a prime target for specific therapies to prevent ARDS in sepsis. This translational proposal will define the mechanisms of the injurious effects of hemoglobin in sepsis to move our findings ?from bench to bedside? by validation of new pharmacological targets that could lead to new therapies for sepsis and ARDS.","8791484; 2109379 (contact); ","BASTARACHE, JULIE ANNE; WARE, LORRAINE B (contact);","ZHOU, GUOFEI","08/01/2017","04/30/2021","Acetaminophen; Acute; Acute Lung Injury; Acute respiratory failure; Adult Respiratory Distress Syndrome; antimicrobial; Apoptosis; Area; bench to bedside; Biological Models; Biology; Blood Circulation; Cells; Clinical; Clinical Trials; clinically relevant; Critical Illness; cytochrome c; Death Rate; Disease; Early treatment; Endothelial Cells; Endothelium; Erythrocytes; Fluid Balance; Functional disorder; Goals; Hemeproteins; Hemoglobin; Human; human model; improved; in vivo Model; Injury; Lead; Life; Lung; Mediating; Mediator of activation protein; Membrane Potentials; Microvascular Permeability; Mitochondria; mitochondrial membrane; Modeling; Molecular; Morbidity - disease rate; mortality; mouse model; Mus; new therapeutic target; novel; novel strategies; novel therapeutics; Organ; Outcome; Oxidants; Oxides; Pathogenicity; Patients; Permeability; Pharmacology; Physiological; polymicrobial sepsis; Preparation; prevent; Prevention; Publishing; Pulmonary Edema; Reducing Agents; Research; Sepsis; targeted treatment; Testing; therapeutic evaluation; Translating; translational study; Translations; Validation; Work; ","Targeting cell-free hemoglobin in sepsis to reduce lung microvascular permeability: mechanistic and translational studies","135849","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","","04","332226","178979","511205",""
"9928064","R01","AI","8","N","05/20/2020","05/20/2020","04/30/2021","859","R01AI150493","SCHOOLS OF ARTS AND SCIENCES","PA-18-484","8R01AI150493-06","NIAID:398397\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","COLUMBUS","UNITED STATES","CHEMISTRY","03","832127323","US","6218701","OHIO STATE UNIVERSITY","OH","432101016","Project Narrative HIV-1 replication requires human tRNALys3 and human lysyl-tRNA synthetase. Understanding the mechanism of essential host cell factor recruitment into HIV-1 particles will provide new therapeutic targets to combat AIDS. These cellular factors interact with the genomic RNA and characterizing these interactions may lead to the development of novel anti-viral agents.","1883156; ","MUSIER-FORSYTH, KARIN M;","REFSLAND, ERIC WILLIAM","09/01/2014","04/30/2023","5' Untranslated Regions; Acquired Immunodeficiency Syndrome; Address; Affect; Affinity; Amino Acyl Transfer RNA; Antibodies; Antiviral Agents; Back; base; Binding; Binding Sites; Cell membrane; Cell Nucleus; Cells; Co-Immunoprecipitations; combat; Complex; Confocal Microscopy; CRISPR/Cas technology; crosslink; Cryoelectron Microscopy; design; Development; Dimerization; Elements; Event; Fluorescence Resonance Energy Transfer; Genetic Transcription; genomic RNA; Grant; HIV-1; Human; In Vitro; Infection; insight; Lead; Ligase; Location; Lysine-Specific tRNA; Lysine-tRNA Ligase; Measures; Molecular Conformation; Mutation; new therapeutic target; Northern Blotting; novel; novel therapeutics; Nuclear; Nuclear Export; Nuclear Localization Signal; Nucleic Acid Binding; particle; Pathway interactions; Phosphorylation; Process; Protein Isoforms; recruit; Reporting; Resolution; Reverse Transcription; Ribosomes; RNA; RNA Conformation; RNA-Directed DNA Polymerase; Roentgen Rays; Role; scaffold; Signal Transduction; single molecule; Specificity; Structure; Testing; therapeutic target; Time; transcriptome sequencing; Transfer RNA; Viral; Virion; Work; ","Cellular Factors Critical for Initiation of HIV-1 Reverse Transcriptase","150493","ZRG1","Special Emphasis Panel ","","","06","295705","102692","398397",""
"10089161","U01","FD","1","N","05/18/2020","05/15/2020","04/30/2021","103","U01FD006921","","RFA-FD-20-006","1U01FD006921-01","FDA:1000000\","Non-SBIR/STTR RPGs","2020","FOOD AND DRUG ADMINISTRATION","","WASHINGTON","UNITED STATES","","98","080208543","US","10041615","NATIONAL FARMERS UNION FOUNDATION","DC","200016700","Local Food Safety Collaborative (LFSC) is dedicated to enhancing the fundamental knowledge of food safety and especially on-farm good agricultural practices of local food producers (farmers and processors) who have a unique place within the Food Safety Modernization Act (FSMA) regulations. By leveraging the results of the LFSC Needs Assessment, previous food safety project experience, and partner organizations? areas of expertise, this program will provide education, outreach and training; develop an alternate curriculum; and build capacity and infrastructure via technical assistance. LFSC is dedicated to helping local producers advance their food safety knowledge and capacity in order to increase compliance and enable them to continue providing consumers with safe, healthy local food.","15399941; ","MATZEN, CHELSEA ;","SALEM, SCARLETT","05/15/2020","04/30/2022","","Local Food Safety Collaborative","006921","ZFD1","Special Emphasis Panel ","","","01","","","1000000",""
"10052724","R01","AI","1","N","05/18/2020","05/18/2020","04/30/2021","855","R01AI146330","SCHOOLS OF ARTS AND SCIENCES","PA-19-056","1R01AI146330-01A1","NIAID:373116\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","TALLAHASSEE","UNITED STATES","BIOLOGY","05","790877419","US","513804","FLORIDA STATE UNIVERSITY","FL","323064166","PROJECT NARRATIVE Guanylate-binding protein 2 (GBP2) is a major interferon-inducible GTPase that fights against microbial pathogens by disrupting their membranous replicative niche. Structural and mechanistic insights gleaned from this research will fill a major gap in the knowledge of pathogen detection and elimination by cell autonomous immunity and will shed light upon the design of new therapeutics for both infectious and autoinflammatory diseases.","10361919; ","YIN, QIAN ;","ROTHERMEL, ANNETTE L","05/18/2020","04/30/2025","Address; analog; antimicrobial; Attention; autoinflammatory; Bacteria; Bacteriolysis; base; Binding; Binding Proteins; Biochemical; Biological Assay; biophysical techniques; Biophysics; cell growth regulation; Cells; Complex; Coupled; Coupling; Cryoelectron Microscopy; cryogenics; Crystallization; Crystallography; cytokine; Cytolysis; Data; design; Detection; Development; Disease; Dynamin; Electron Microscopy; enzyme activity; Enzyme Kinetics; Exposure to; Extravasation; Family; fight against; Fluorescence; Glean; Goals; Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; guanylate; Higher Order Chromatin Structure; Human; Hydrolysis; Immune; Immunity; Individual; Infection; Inflammation; insight; Interferons; Knowledge; Lead; Length; Light; light scattering; Lipids; Liposomes; Maps; Measures; Membrane; microbial; Modeling; Molecular; Molecular Conformation; novel therapeutics; Nucleotides; Parasites; pathogen; Pathogen detection; pathogen exposure; pathogenic microbe; Pattern recognition receptor; Play; Process; protein activation; Protein Activation Pathway; Proteins; prototype; reconstitution; recruit; Regulation; Research; response; Role; Rupture; Structure; System; Techniques; Toxoplasma gondii; unilamellar vesicle; Vacuole; Work; X-Ray Crystallography; ","Mechanistic Insights into Activation and Regulation of Interferon-inducible GTPase GBP2","146330","CMIA","Cellular and Molecular Immunology - A Study Section ","","A1","01","250000","123116","373116",""
"10145924","U19","AI","3","N","05/21/2020","05/21/2020","06/30/2020","855","U19AI111143","SCHOOLS OF MEDICINE","PA-20-135","3U19AI111143-06S1","NIAID:353106\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW YORK","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","12","060217502","US","1514803","WEILL MEDICAL COLL OF CORNELL UNIV","NY","100654805","Narrative We propose to study a combined cohort of 3,054 adults in Haiti and Tanzania to determine the attack rate of SARS-CoV-2 infection and severe COVID-19 in low-income countries, to examine interactions with HIV infection, pulmonary tuberculosis, and hypertension in populations of African descent, and to determine long term cardiac complications of COVID-19. Cornell University has collaborated with the Groupe Haitien d?Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) in Haiti for 38 years and for 15 years with the Mwanza Intervention Trials Unit (MITU) in Tanzania. The proposed emergency supplement leverages these collaborations and four established NIH-supported cohorts, which have already been enrolled, to generate data essential for the prevention and care of COVID-19 in low-income countries and the world.","1865699; 1860967 (contact); ","GLICKMAN, MICHAEL STEPHEN; NATHAN, CARL F (contact);","MENDEZ, SUSANA","05/21/2020","06/30/2021","2019-nCoV; Acquired Immunodeficiency Syndrome; Address; Adult; African; Antibodies; Area; Arrhythmia; Autopsy; Cardiac; Caring; Cellular Phone; Cessation of life; Chronic lung disease; Clinical; Clinical Trials; cohort; Cohort Analysis; Collaborations; Communication; Communities; Conduct Clinical Trials; Country; COVID-19; Data; Development; Disease; Echocardiography; Electrocardiogram; Emergency Situation; Enrollment; Epidemic; falls; follow-up; Functional disorder; Funding; Future; Geography; Goals; Haiti; Haitian; Health; Heart Diseases; heart function; Heart Injuries; HIV; HIV Infections; HIV/TB; Home environment; Hospital Records; Hypertension; Immunoglobulin G; improved; Incidence; Income; Infection; Infrastructure; Intervention Trial; Left; Left Ventricular Function; Low income; low income country; mortality; Motion; Myocardial Ischemia; Myocarditis; National Institute of Allergy and Infectious Disease; Natural History; Outcome; pandemic disease; Participant; Patients; Population; Positioning Attribute; Prevalence; Prevention; Preventive Intervention; Procedures; Protocols documentation; public health intervention; Pulmonary Hypertension; Pulmonary Tuberculosis; Report (document); Reporting; Research; Research Infrastructure; Risk; Risk Factors; Seminal; Serologic tests; Severities; Survivors; symptomatology; Symptoms; Tanzania; Telephone; Telephone Interviews; Troponin; United States National Institutes of Health; Universities; Ventricular; Viral Respiratory Tract Infection; Virus Diseases; Visit; World Health Organization; ","Tri-Institutional TB Research Unit: Persistence and Latency","111143","ZAI1","Special Emphasis Panel ","","S1","06","307933","45173","353106",""
"9918958","R01","HL","5","N","05/20/2020","04/01/2020","03/31/2021","838","R01HL133163","BIOMED ENGR/COL ENGR/ENGR STA","PA-16-160","5R01HL133163-04","NHLBI:383414\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NEWARK","UNITED STATES","BIOMEDICAL ENGINEERING","00","059007500","US","2076701","UNIVERSITY OF DELAWARE","DE","197160000","PROJECT NARRATIVE Congenital diaphragmatic hernia (CDH) is a devastating and costly birth defect resulting in a severe and often lethal failure of lung development. We have recently uncovered a novel pressure-based biophysical mechanism that regulates lung development. In this proposal, we seek to uncover the molecular mechanisms that guide this regulation to identify novel therapeutic targets for the treatment of CDH.","11335181; ","GLEGHORN, JASON PAUL;","LIN, SARA","04/01/2017","03/31/2022","Abdomen; Address; Affect; airway epithelium; Animal Model; Animals; base; Biophysical Process; Biophysics; Calmodulin; Chest; clinical translation; Coculture Techniques; Congenital Abnormality; Congenital diaphragmatic hernia; cost; Data; Development; Devices; Electrophysiology (science); embryo surgery; Engineering; Event; Exhibits; Failure; Feedback; fetal; Fetal Lung; Fetal Mortality Statistics; Fluids and Secretions; Future; Grant; Growth; Guanine Nucleotide Exchange Factors; Human; Hypoxemia; In Vitro; in vitro Model; Ion Channel; keratinocyte growth factor; KRAS2 gene; Light; Link; Liquid substance; Live Birth; Lung; lung basal segment; lung development; lung pressure; malformation; Mechanics; mechanotransduction; Mediating; medical specialties; Microfluidics; Modeling; Molecular; Morbidity - disease rate; Morphogenesis; mortality; Mus; Muscle Contraction; Muscle function; Mutation; Myosin Light Chain Kinase; Neonatal; new therapeutic target; Newborn Infant; novel; Operative Surgical Procedures; Organ; Organ Culture Techniques; Pathway interactions; perinatal morbidity; Perinatal mortality demographics; Peristalsis; Pharmacology; Plasmids; Play; pressure; Proteins; pulmonary hypoplasia; Pump; ras Proteins; Regulation; Replacement Therapy; Respiratory Diaphragm; Respiratory Insufficiency; respiratory smooth muscle; response; Risk; Role; Severities; Signal Pathway; Signal Transduction; Small Interfering RNA; stem; Stimulus; Stretching; Structural Congenital Anomalies; Structural defect; Structure of parenchyma of lung; success; Survival Rate; System; targeted treatment; Techniques; Testing; therapeutic target; Thoracic cavity structure; Trachea; Transfection; Translating; treatment strategy; Work; ","Pressure in lung development and congenital diaphragmatic hernia","133163","LIRR","Lung Injury, Repair, and Remodeling Study Section ","","","04","250000","133414","383414",""
"9889107","T32","DK","5","N","05/20/2020","05/01/2020","04/30/2021","847","T32DK007013","","PA-18-403","5T32DK007013-42","NIDDK:221498\","TRAINING, INSTITUTIONAL","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","ROCHESTER","UNITED STATES","","01","006471700","US","4976101","MAYO CLINIC ROCHESTER","MN","559050001","NARRATIVE Developing the next generation of physicians and scientists is essential for the successful pursuit of new treatments for kidney diseases; this postdoctoral training grant will assist in achieving this goal.","1885395; ","LIESKE, JOHN C;","SPRUANCE, VICTORIA MARIE","07/01/1975","04/30/2024","Kidney Diseases; Research Training; Training Programs; ","Kidney Disease Research Training Program","007013","ZDK1","Special Emphasis Panel ","","","42","206538","16523","221498",""
"9964676","U54","CA","5","N","05/18/2020","05/01/2020","04/30/2021","","U54CA209988","","RFA-CA-15-014","5U54CA209988-04","NCI:202163\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","1943901; ","GRAY, JOE W.;","","","","3-Dimensional; Address; Algorithmic Analysis; Algorithms; Architecture; Back; base; Biological Assay; Biological Markers; cancer heterogeneity; Cell Culture Techniques; Cell Line; Cells; Cellular Morphology; Characteristics; Classification; Collaborations; Complex; Computer software; Computer Systems; Custom; Data; data management; Data Storage and Retrieval; Databases; Development; Electron Microscope; Electrons; Environment; experimental study; Face; feature extraction; flexibility; fluorescence imaging; Heterogeneity; high dimensionality; High Performance Computing; Image; Image Analysis; image reconstruction; imaging approach; Imaging Device; imaging Segmentation; imaging system; Immunofluorescence Immunologic; Individual; Infrastructure; Ingestion; insight; Label; Light Microscope; light microscopy; Link; Machine Learning; Measurement; Measures; Metadata; Methods; Microscopic; Modeling; multimodality; Nature; novel; open source; outreach; Performance; Periodicity; Pharmaceutical Preparations; Phenotype; Population; Procedures; Process; protocol development; Protocols documentation; Qi; quality assurance; Quality Control; quantitative imaging; repository; Resolution; Resource Sharing; Resources; response; Scanning Electron Microscopy; screening; segmentation algorithm; Selection Criteria; Structure; System; Systems Biology; Tissues; tool; Visualization; Visualization software; ","Imaging Management and Analysis Core","209988","ZCA1","Special Emphasis Panel ","8356","","04","179168","22995","","202163"
"9952112","F30","HL","5","N","05/18/2020","05/01/2020","04/30/2021","837","F30HL146006","SCHOOLS OF MEDICINE","PA-18-673","5F30HL146006-02","NHLBI:50520\","TRAINING, INDIVIDUAL","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PHILADELPHIA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","057123192","US","8240301","TEMPLE UNIV OF THE COMMONWEALTH","PA","191226003","Project Narrative This project will help elucidate the mechanism and consequence of mitochondrial Drp1-dependent fission, a critical event in mitochondrial quality control and homeostasis. Dysregulated mitochondrial fission is identified as a contributor in neurodegenerative and cardiovascular dysfunction. These results will provide insights into how mitochondrial fission is involved in mediating hypertensive vascular remodeling and further our progress towards identifying novel therapeutic targets to slow the rate of end organ damage seen in patients with chronic hypertension.","14727050; ","COOPER, HANNAH ABIGAIL;","MEADOWS, TAWANNA","05/01/2019","04/30/2021","3-nitrotyrosine; Address; Adult; Affect; American; Angiotensin II; Angiotensins; Antihypertensive Agents; Aorta; Attenuated; attenuation; base; Binding; Blood Pressure; blood pressure reduction; Blood Vessels; C57BL/6 Mouse; Cardiovascular Diseases; cardiovascular risk factor; Cardiovascular system; Career Choice; Cell Volumes; Cells; Cessation of life; Chronic; Collagen; Coronary artery; cost; Data; design; Dynamin; endoplasmic reticulum stress; Epidermal Growth Factor Receptor; Event; experimental study; extracellular; Functional disorder; Generations; Grant; Guanosine Triphosphate Phosphohydrolases; Guidelines; Heart; Heart Diseases; Homeostasis; Hypertension; Hypertrophy; In Vitro; in vivo; Infusion procedures; insight; Intervention; Kidney; Kidney Diseases; Knockout Mice; Knowledge; Lead; Left Ventricular Hypertrophy; Mammals; Mediating; Mitochondria; mitochondrial dysfunction; Modeling; Molecular; Morbidity - disease rate; mortality; Mus; Nerve Degeneration; new therapeutic target; normotensive; novel; Organ; Oxidative Stress; Pathology; Patients; Perivascular Fibrosis; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Phosphorylation; Physicians; Prevalence; prevent; Primary Health Care; Process; Production; Protein Biosynthesis; Proteins; Proteomics; Quality Control; Rattus; Reactive Oxygen Species; receptor; renal artery; Reporting; Research; Research Personnel; Role; Scientist; Signal Transduction; Smooth Muscle Myocytes; Stains; Stroke; Techniques; Testing; Tissues; Training; Transactivation; Universities; Vascular remodeling; Vascular Smooth Muscle; Viral; ","Mitochondrial fission mediates hypertensive vascular remodeling","146006","ZRG1","Special Emphasis Panel ","","","02","50520","","50520",""
"10140002","R00","AI","3","N","05/21/2020","05/21/2020","11/30/2020","855","R00AI123498","ORGANIZED RESEARCH UNITS","PA-18-935","3R00AI123498-03S1","NIAID:129120\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","MADISON","UNITED STATES","MISCELLANEOUS","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","PROJECT NARRATIVE Molecular characterization of a novel virus has the potential to accelerate the development of SARS-CoV-2 therapeutics. Understanding how viral machines replicate the viral RNA genome and are inhibited by nucleotide analogue drugs is key to the development of therapeutics for the treatment of COVID-19.","11792638; ","KIRCHDOERFER, ROBERT NICHOLAS;","STEMMY, ERIK J","05/21/2020","11/30/2020","2019-nCoV; Active Sites; Animals; Antiviral Agents; Biochemical; Biological Assay; Blood Circulation; Catalysis; Cessation of life; Cleaved cell; Clinical Trials; combat; Complement; Complex; Coronavirus; Coronavirus Infections; COVID-19; Cryoelectron Microscopy; Development; Disease Outbreaks; Event; experience; Family; Genetic Transcription; Genome; Geography; Goals; high resolution imaging; Human; human coronavirus; Imaging Techniques; inhibitor/antagonist; Investigational Drugs; Life Cycle Stages; Lung diseases; Middle East Respiratory Syndrome Coronavirus; Molecular; Mutagenesis; Nonstructural Protein; novel; novel virus; nucleotide analog; particle; Pathogenicity; Pharmaceutical Preparations; Polymerase; Polyproteins; protein complex; protein function; Proteins; Recombinant Proteins; Recording of previous events; remdesivir; RNA; RNA Binding; RNA chemical synthesis; RNA-Directed RNA Polymerase; RNA-Protein Interaction; SARS coronavirus; small molecule; Speed; Structural Biochemistry; structural biology; Structure; Techniques; Testing; Therapeutic; therapeutic development; Time; Viral; Viral Genome; Viral Proteins; viral RNA; Virus; Virus Replication; ","Structural Studies of the Corona Virus Life Cycle","123498","","","","S1","03","85787","43333","129120",""
"10119908","R01","GM","3","N","05/20/2020","01/01/2020","11/30/2020","859","R01GM043880","SCHOOLS OF MEDICINE","PA-18-906","3R01GM043880-28S1","NIGMS:30580\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RICHMOND","UNITED STATES","BIOCHEMISTRY","04","105300446","US","353201","VIRGINIA COMMONWEALTH UNIVERSITY","VA","232980568","Project Narrative Histone deacetylases (HDACs) remove acetyl groups from histones and regulate gene expression and inhibitors of HDACs have long been used in psychiatry and various neurological diseases. We discovered that the sphingolipid metabolite, sphingosine-1-phosphate, produced in the nucleus by sphingosine kinase 2 is an endogenous inhibitor of HDACs. Understanding how sphingosine-1-phosphate regulates functions of HDACs should provide fundamental insights into the molecular and cellular basis of histone acetylations and gene expression and their involvement in memory and may pave the way for effective therapies aimed at reversing memory dysfunction.","1868561; ","SPIEGEL, SARAH ;","NIE, ZHONGZHEN","04/01/1990","11/30/2023","Acetylation; Affect; Aging; Agonist; analog; autocrine; Binding; Binding Sites; Brain; Brain Diseases; cancer therapy; Cardiovascular system; Cell Nucleus; Cells; Chromatin; chromatin modification; Cognition Disorders; Coin; CREB1 gene; Cues; Disease; effective therapy; Enzymes; Epigenetic Process; epigenetic regulation; epigenome; Event; Family; fascinate; G-Protein-Coupled Receptors; Gene Expression; Gene Expression Regulation; Genes; Genetic; genetic inhibitor; genome-wide; HDAC1 gene; HDAC2 gene; Health; Hippocampus (Brain); Histone Acetylation; Histone Deacetylase; Histone Deacetylase Inhibitor; Histones; Immune; Immunomodulators; Immunosuppressive Agents; improved; In Situ; in vivo; inorganic phosphate; insight; interest; Knockout Mice; Learning; Ligands; Link; Lipids; Location; lymph nodes; Lymphocyte; member; Memory; Memory impairment; memory process; Metabolism; migration; mimetics; Molecular; Multiple Sclerosis; multiple sclerosis treatment; Mus; nervous system disorder; Neuraxis; non-histone protein; novel strategies; Nuclear; paracrine; Pathologic Processes; Pharmacology; pharmacophore; Physiological Processes; Play; preclinical study; Process; Prodrugs; Production; programs; promoter; Psychiatry; Receptor Signaling; recruit; Regulation; Role; Signal Transduction; Signal Transduction Pathway; small molecule; Sphingolipids; Sphingosine; sphingosine 1-phosphate; sphingosine kinase; Sphingosine-1-Phosphate Receptor; Tail; Testing; Therapeutic; trafficking; transcription factor; Zinc; ","Intracellular Functions of the Bioactive Sphingolipid Metabolites Sphingosine and Sphingosine-1-phosphate","043880","","","","S1","28","22480","8100","30580",""
"9932805","U01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","838","U01HL123027","SCHOOLS OF MEDICINE","RFA-HL-14-014","5U01HL123027-07","NHLBI:239024\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","WINSTON-SALEM","UNITED STATES","INTERNAL MEDICINE/MEDICINE","05","937727907","US","9021205","WAKE FOREST UNIVERSITY HEALTH SCIENCES","NC","271570001","PUBLIC HEALTH RELEVANCE: The Investigators propose to promote health by prevention and treatment of acute lung injury through PETAL network participation and use of unique resources at Wake Forest University Health Sciences, the University of Virginia Health System, Moses Cone Health Systems and Virginia Commonwealth Health System.","9547421; 8713924 (contact); ","FILES, DANIEL CLARK; MILLER, CHADWICK DAVID (contact);","REINECK, LORA A","06/17/2014","04/30/2021","Accident and Emergency department; Acute; Acute Lung Injury; Address; Adult Respiratory Distress Syndrome; Ascorbic Acid; Baptist Church; Center for Translational Science Activities; Clinical; Clinical Research; Clinical trial protocol document; Clinical Trials; Collaborations; Communication; Community Hospitals; Community Practice; Conduct Clinical Trials; Cone; Critical Care; Critical Illness; Department of Defense; design; Development; Early Intervention; Early treatment; Emergency Medicine; Emergency Situation; Enrollment; Environment; experience; Faculty; follow-up; forest; Funding; Geography; Goals; Grant; Health; Health Promotion; Health Sciences; Health system; hospital readmission; Hospitals; Human Resources; improved; Infusion procedures; innovation; Institution; Interdisciplinary Study; Intervention; Leadership; Link; Lung; lung injury; Medical center; meetings; Multi-Institutional Clinical Trial; Multicenter Studies; National Heart, Lung, and Blood Institute; novel; operation; Operative Surgical Procedures; Participant; patient population; Patient-Focused Outcomes; Patients; Performance; Positioning Attribute; prevent; Prevention; Principal Investigator; Private Practice; Procedures; Protocols documentation; public health relevance; Recording of previous events; recruit; Research; Research Personnel; Research Support; Resources; Risk; Role; S Phase; Seasons; Services; severe injury; Site; Structure; Suggestion; Survivors; Trauma; trial design; United States National Institutes of Health; Universities; Virginia; Work; Writing; ","Wake Forest Clinical Center for the NHLBI PETAL Network","123027","ZHL1","Special Emphasis Panel ","","","07","180467","58557","239024",""
"10127232","R01","GM","7","N","05/22/2020","01/02/2020","04/30/2020","859","R01GM132261","SCHOOLS OF MEDICINE","PA-18-590","7R01GM132261-02","NIGMS:286224\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","PHILADELPHIA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","057123192","US","8240301","TEMPLE UNIV OF THE COMMONWEALTH","PA","191226003","1. PROJECT NARRATIVE  In eukaryotic cells, metabolites are compartmentalized to distinct parts of the cell to exchange chemical energy, maintain redox balance, act as signaling molecules, and to meet the needs of proliferation. This research develops, validates, and then uses state of the art techniques to directly quantify metabolites in each part of the cell to understand how they change as part of normal cellular and pathophysiological states.","10234449; ","SNYDER, NATHANIEL W.;","BARSKI, OLEG","08/01/2019","04/30/2024","","Quantification of compartmentalized metabolism in eukaryotic systems","132261","ZRG1","Special Emphasis Panel ","","","02","180583","105641","286224",""
"9928434","T32","HD","5","N","05/18/2020","05/01/2020","04/30/2021","865","T32HD049302","SCHOOLS OF MEDICINE","PA-16-152","5T32HD049302-14","NICHD:375866\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","MADISON","UNITED STATES","OBSTETRICS & GYNECOLOGY","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","PROJECT NARRATIVE Health inequalities in the United States are large and persistent, and begin early in life. The Health Disparities Research Scholars program will train post-doctoral scholars to become interdisciplinary researchers who will advance the knowledge on the causes, consequences, and tools needed to reduce health disparities and inequities, and improve public health.","8622535; ","EHRENTHAL, DEBORAH BETH;","BURES, REGINA M","05/23/2007","04/30/2022","health disparity; Research; Training Programs; ","Health Disparities Research Scholars Training Program","049302","ZHD1","Special Emphasis Panel ","","","14","387324","26646","375866",""
"10118005","I01","VA","5","N","05/22/2020","04/01/2020","03/31/2021","999","I01BX002880","","RFA-BX-15-001","5I01BX002880-05","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","MADISON","UNITED STATES","","02","086683091","US","481071","WM S. MIDDLETON MEMORIAL VETERANS HOSP","WI","537052254","PUBLIC HEALTH RELEVANCE        Obstructive sleep apnea (OSA) is poised to take more of a central role in the health care of Veterans. Between 2009 and 2014, OSA ranking rose from the 69th to 45th most common diagnosis in the VHA Support Service Center database. Moreover, in 2014, chronic airways obstruction/asthma ranked as the 16th in the same database. Apart from their frequent co-existance, these diseases interact with, and worsen, one another. In our preliminary work, chronic intermittent hypoxia (CIH)-a hallmark feature of OSA-administered during allergen-induced airway inflammation led to airflow deficits, as a result of shift toward Th-1 - predominant airway inflammation and detrimental changes to lung structure, which may be irreversible. Herein, we will test the physiologic, cellular and molecular mechanisms underlying the CIH-induced airway obstruction during allergen challenge. Our research will lead to more targeted and effective therapies for Veterans afflicted by OSA/asthma, and will be highly relevant to other common lung diseases, such as emphysema and fibrosis.","8920922; ","TEODORESCU, MIHAELA ;","","04/01/2016","03/31/2021","Address; Adrenal Cortex Hormones; Airway Disease; airway inflammation; airway obstruction; airway remodeling; Airway Resistance; Allergens; Allergic; Asthma; asthmatic patient; Attenuated; Benefits and Risks; Bone Marrow; Bronchoalveolar Lavage; Bronchodilator Agents; Caring; Chronic; chronic airflow obstruction; Clinical; Collaborations; Collagen; comorbidity; Data; Databases; density; Deposition; design; Development; Diagnosis; Dichloromethylene Diphosphonate; Disease; disorder control; Distal; effective intervention; effective therapy; Enzyme-Linked Immunosorbent Assay; experimental study; Exposure to; Fibrosis; Flow Cytometry; Functional disorder; Goals; Healthcare; Histologic; Histology; Hypoxia; Immunohistochemistry; Inflammation; Inflammatory; Inhalation; inhibitor/antagonist; innovation; Investigation; Knowledge; Link; Literature; Lung; Lung diseases; macrophage; Marrow; Measures; Modeling; Molecular; monocyte; Morbidity - disease rate; mortality; novel; Obstructive Sleep Apnea; Oxygen; Pathway interactions; Patients; Phenotype; Physiological; Plasminogen Activator Inhibitor 1; Positioning Attribute; prevent; Process; Property; protein expression; public health relevance; Publishing; Pulmonary Emphysema; Pulmonary Fibrosis; Pyroglyphidae; Quality of life; Rat-1; Rattus; Rattus norvegicus; Research; Research Methodology; Resistance; Respiratory physiology; Rodent Model; Role; Saline; screening; Services; Smooth Muscle; Structure; Structure of parenchyma of lung; System; targeted treatment; Testing; Therapeutic; Tissues; Veterans; Work; ","Mechanisms of Chronic Intermittent Hypoxia Induced Airflow Obstruction during Allergic Lower Airway Inflammation","002880","PULM","Respiration ","","","05","","","",""
"9922356","R01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","838","R01HL137203","SCHOOLS OF MEDICINE","PA-16-160","5R01HL137203-04","NHLBI:488717\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","HOUSTON","UNITED STATES","GENETICS","09","051113330","US","481201","BAYLOR COLLEGE OF MEDICINE","TX","770303411","PROJECT NARRATIVE We will elucidate how tissue-specific distant enhancer in chromosome 16q24.1 including long noncoding RNAs (lncRNAs) regulate expression of FOXF1, the gene responsible for a neonatal diffuse developmental disorder of the lungs, alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), commonly associated with multiple congenital malformations involving the cardiac, gastrointestinal, and genitourinary systems. We will study the role of lncRNAs in genomic imprinting of the FOXF1 locus on chromosome 16q24.1. We will determine whether genomic imprinting at chromosome 16q24.1 is responsible for the phenotype of maternal UPD(16). We will also study the function of lncRNA FENDRR in development of lungs, heart and placenta. LncRNAs are considered promising therapeutic targets and we believe that by manipulating their expression, we may have the potential to correct the lethal phenotype of ACDMPV and UPD(16).","7774531; ","STANKIEWICZ, PAWEL ;","LIN, SARA","05/22/2017","04/30/2021","Address; Alveolar capillary dysplasia with misalignment of pulmonary veins; base; Blood Vessels; Cardiac; cardiogenesis; Child; Chromatin; Chromosome 16; Chromosomes; Clinical; Code; Collection; Complex; Congenital Abnormality; Defect; Deletion Mutation; Development; developmental disease; Diffuse; Disease; Distant; Embryo; Endothelium; Enhancers; Epigenetic Process; epigenomics; Epithelial; Epithelium; Family; Fetal Growth Retardation; Fetal Lung; Fistula; FOXF1 gene; Functional disorder; Gallbladder; gastrointestinal system; Gene Expression; Gene Expression Regulation; Genes; Genetic Nondisjunction; Genitourinary system; genome-wide; Genomic Imprinting; Genomics; Heart; Heart Abnormalities; Heart Diseases; Human; Human Cell Line; Hydronephrosis; Hypoplastic Left Heart Syndrome; Imperforate Anus; imprint; Junk DNA; Knock-out; Knowledge; Lead; Ligands; Lung; lung development; Lung diseases; Maps; Maternal uniparental disomy; Meiosis; Mesenchymal; Mesenchyme; Methylation; Molecular; Molecular Conformation; Mus; Neonatal; neonate; Online Mendelian Inheritance In Man; Parents; Patients; Perinatal; Phenotype; Placenta; Play; Point Mutation; Pregnancy; prenatal; Process; promoter; Proteins; pulmonary hypoplasia; Regulation; Regulator Genes; renal agenesis; Reporting; Role; Sampling; Signal Transduction; Smooth Muscle Myocytes; Sonic Hedgehog Pathway; spatiotemporal; Structure of umbilical artery; therapeutic target; Tissues; transcription factor; transcriptome; Trisomy; Trisomy 16; Untranslated RNA; Upstream Enhancer; ","Epigenomic dysfunction at 16q24.1 vascular defects and perinatal consequences","137203","PN","Pregnancy and Neonatology Study Section ","","","04","308339","180378","488717",""
"9932485","R01","HL","5","N","05/22/2020","05/01/2020","04/30/2021","838","R01HL143364","SCHOOLS OF MEDICINE","PAR-18-133","5R01HL143364-02","NHLBI:799270\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PHILADELPHIA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","PROJECT NARRATIVE Few interventions to improve asthma management have targeted low-income minority asthmatic adults, particularly older adults who often also have other health problems. National guidelines focus on children and young adults leaving asthma providers with little evidence-based data to guide clinical decisions for adult patients with multiple comorbidities. This project tests guideline-promoted interventions, delivered by community health navigators in clinical practices and in the home, with feedback to clinicians, to improve asthma control and quality of life for adults with uncontrolled asthma recruited from clinics serving low-income urban neighborhoods.","1946520 (contact); 6685312; ","APTER, ANDREA J. (contact); BRYANT-STEPHENS, TYRA C;","FREEMER, MICHELLE M","06/01/2019","04/30/2023","Address; Adherence; Adult; Advocate; Affect; African American; Appointment; Asthma; asthmatic; asthmatic patient; Attention; base; Behavior Therapy; care coordination; care outcomes; Caring; Cessation of life; Child; Chronic; Chronic Disease; Clinic; Clinic Visits; Clinical; clinical practice; Communication; Community Health; Community Health Aides; comorbidity; cost; Data; design; Diabetes Mellitus; Diagnosis; Disease; Economics; Education; Effectiveness; Elderly; Elements; Emergency department visit; Ensure; Evaluation; evidence base; Failure; Feedback; Guidelines; Health; health care service utilization; health disparity; Health Services Accessibility; Hearing; Home environment; Home visitation; Hospitalization; household environmental exposure; Housing; Huntingtin-Associated protein 1; Hypertension; Improve Access; improved; improved outcome; Infrastructure; Inhalation; Intervention; intervention cost; Interview; literacy; Low income; medical specialties; Minority; Monitor; Neighborhoods; Obesity; Office Visits; older patient; Outcome; patient-clinician communication; Patients; Pharmaceutical Preparations; Poverty; Prednisone; Primary Health Care; program costs; Protocols documentation; Provider; Quality of life; Randomized; Recommendation; recruit; Reporting; Risk; Savings; social; socioeconomics; Steroids; Structure; Testing; Time; Transportation; Visit; Voice; young adult; ","Clinic navigation and home visits to improve guideline-based care and outcomes in low income minority adults with asthma","143364","ZRG1","Special Emphasis Panel ","","","02","522346","276924","799270",""
"10125077","I01","VA","5","N","05/22/2020","10/01/2019","09/30/2020","999","I01BX002806","","RFA-BX-14-001","5I01BX002806-05","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","BOSTON","UNITED STATES","","07","034432265","US","481041","VA BOSTON HEALTH CARE SYSTEM","MA","021304817","PUBLIC HEALTH RELEVANCE:         Appropriate medical care of diabetes represents an enormous problem in the VHA, particularly as the already large number of diabetic veterans continues to grow. The prevalence of diabetes in the VHA system rose from 16.7% in fiscal year 1998 to 19.6% in fiscal year 2000 (Miller 2004). Moreover, care of diabetic veterans poses a special problem because of associated morbidities such as age and post-traumatic stress disorder. Since VHA is a continuing system of care, we are confronted with long-term complications of diabetes. Gastrointestinal complications are common, cause significant morbidity and seriously confound the management of diabetes. Despite an excellent record of adherence to medical guidelines, the management of gastric complications of diabetes remains unsatisfactory, in part because the mechanism of gastric emptying abnormalities is poorly understood. A proper understanding of the pathogenesis of gastric complications of diabetes may not only ameliorate morbidity associated with gastroparesis but help improve its management.","1862106; ","GOYAL, RAJ K;","","10/01/2015","09/30/2020","Adherence; Affect; Age; Age-Years; Anatomy; Animal Model; Animals; Attenuated; base; care systems; Caring; cell motility; cell type; Characteristics; cholinergic; Chronic Disease; Clinical; comorbidity; Complex; Complications of Diabetes Mellitus; cost; Data; Defect; design; diabetes management; Diabetes Mellitus; diabetic; diabetic gastroparesis; Diabetic mouse; Diagnosis; Disease; Elderly; Electrophysiology (science); Enteral; Etiology; Expenditure; Experimental Designs; experimental study; Food; Functional disorder; Fundus; Gastric Emptying; gastric fundus; gastrointestinal; Gastroparesis; Guidelines; Human; human disease; Hyperglycemia; Impairment; improved; Inbred DBA Mice; Individual; Ingestion; innovation; Interstitial Cell of Cajal; Liquid substance; Mechanics; Mediating; Medical; Modeling; Modification; Molecular; Morbidity - disease rate; Motor; Mus; Muscle; MYO5A gene; Myosin ATPase; Nature; Nerve; neuromuscular; neuromuscular transmission; Neurons; neurotransmission; Neurotransmitters; new therapeutic target; novel; Pathogenesis; Pathology; Pathway interactions; Patients; Pattern; Pharmacology; Phenotype; Phosphorylation; PI3 gene; Play; Population; Post-Traumatic Stress Disorders; premature; Prevalence; Process; public health relevance; Pyloric sphincter structure; Pylorus; Regulation; Relaxation; Reporting; Reproducibility; response; Role; Signal Pathway; Smooth Muscle; Solid; statistics; Stomach; Symptoms; System; Techniques; Testing; transmission process; Treatment Efficacy; treatment guidelines; Varicosity; Veterans; ","Pathophysiology of Diabetic Gastroparesis","002806","GAST","Gastroenterology ","","","05","","","",""
"9911437","F30","AI","1","N","12/16/2019","03/01/2020","02/28/2021","855","F30AI150049","SCHOOLS OF MEDICINE","PA-19-191","1F30AI150049-01","NIAID:50520\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","CHICAGO","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","07","005436803","US","6144650","NORTHWESTERN UNIVERSITY AT CHICAGO","IL","606113152","Project Narrative Herpes simplex virus is the most common cause of viral encephalitis and results in devastating morbidity and mortality, more commonly in newborns compared to adults. Age or developmental differences in the host response to infection likely account for differences in susceptibility and I will investigate the contribution of the inflammasome. This will not only allow me to elucidate the mechanisms of pathogenesis, but also employ new targeted immunotherapeutics in this disease with limited treatment options.","14667509; ","HAYES, COOPER KINCAID;","BEISEL, CHRISTOPHER E","03/01/2020","02/29/2024","Acyclovir; Address; Adult; Age; age related; AIM2 gene; Antiviral Response; Apoptosis; Brain; CASP1 gene; Cells; Complex; cytokine; Dangerousness; Data; Dependence; Development; Disease; Disease Outcome; DNA; driving force; Encephalitis; Equilibrium; Experimental Autoimmune Encephalomyelitis; experimental study; Herpes encephalitis; Herpesvirus 1; Immune; Immune response; Immunologic Factors; immunopathology; Immunotherapeutic agent; improved; In Vitro; in vivo; Incidence; Individual; Infection; Inflammasome; Inflammation; Inflammatory; insight; interest; interferon alpha receptor; Interferon Receptor; Interferon Type I; Interferons; Interleukin-1; Interleukin-1 beta; Interleukin-18; Ischemic Stroke; Knockout Mice; Live Birth; Lytic; marenostrin; Morbidity - disease rate; mortality; mouse model; Multiprotein Complexes; Mus; Neonatal; neonatal brain; neonatal infection; neonate; Neuraxis; Neurodegenerative Disorders; neuroinflammation; Neurologic; Newborn Infant; Outcome; pathogen; Pathogenesis; Pathology; Pathway interactions; Pattern recognition receptor; Phenotype; Predisposition; prevent; Process; Production; Proteins; Regulation; response; Role; seropositive; Severity of illness; Signal Transduction; Simplexvirus; Stimulus; System; targeted treatment; United States; Viral Encephalitis; Viral Pathogenesis; Virus Diseases; Virus Replication; Work; ","An Age-Dependent Role of the Inflammasome in the Pathogenesis of HSV Encephalitis","150049","ZRG1","Special Emphasis Panel ","","","01","50520","","50520",""
"9984834","R21","TW","5","N","05/18/2020","05/01/2020","04/30/2021","989","R21TW010963","","PAR-18-242","5R21TW010963-02","FIC:174357\","Non-SBIR/STTR RPGs","2020","FOGARTY INTERNATIONAL CENTER","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Managing the hydration status in patients undergoing peritoneal dialysis (PD) is a key task for nephrologists in Thailand that is made difficult due to lack of timely access to hydration metrics including weight, blood pressure, and ultrafiltration volume. Our research project aims to improve the monitoring of hydration status in PD patients from a bimonthly, in-clinic review of a handwritten log-book to a smartphone based app (CKD-PD) with digitized data that allows for near real time monitoring hydration abnormalities, thereby creating the opportunity for earlier treatment of overhydration. We hypothesize that use of the CKD-PD will improve early treatment of overhydration, and potentially reduce the incidence of complications, hospitalizations, and mortality in PD patients.","15033292; ","MORLEY, KATHARINE ELISE;","NEWSOME, BRAD","07/27/2019","04/30/2021","Access to Information; Address; Adopted; Appointment; base; Blood Pressure; Books; Cardiovascular system; Caring; Cellular Phone; Chronic Kidney Failure; Clinic; Clinic Visits; Clinical; Clinics and Hospitals; Collaborations; Collection; Communication; Congestive Heart Failure; cost; Data; Data Display; data visualization; Databases; design; Detection; Development; Devices; Diabetes Mellitus; Dialysis patients; Dialysis procedure; Diet; Early treatment; Educational workshop; Emergency Situation; End stage renal failure; Equipment; Evaluation; Event; Feedback; Fluid overload; General Hospitals; global health; graduate student; graphical user interface; hackathon; Health; Health Care Costs; Health Policy; Healthcare; Hemodialysis; Home environment; Hospitalization; Hospitals; Hydration status; Hypertension; improved; Incidence; individual patient; Infection; innovation; Institution; Intake; interest; Intervention; Interview; Knowledge; Leadership; Link; Liquid substance; low and middle-income countries; Low income; Massachusetts; Measurement; Measures; Methodology; mHealth; Modeling; Monitor; mortality; Nephrology; Notification; novel; Online Systems; Outcome; Paper; Patient Monitoring; Patients; Pattern; Peritoneal Dialysis; Pharmaceutical Preparations; Policies; Population; Positioning Attribute; Prevalence; primary outcome; Process; Public Health; Quality of life; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; real time monitoring; Records; recruit; Renal Replacement Therapy; Research; Research Project Grants; Research Proposals; Rural; Scheme; secondary outcome; Secondary to; Security; sensor; smartphone Application; Software Engineering; Southeastern Asia; Specialist; Specific qualifier value; Structure; Surveys; Technology; Thailand; theories; Time; treatment as usual; trial comparing; Ultrafiltration; Universal Coverage; Universities; usability; Weight; ","Improving Care for Peritoneal Dialysis Patients with the 'CKD-PD' app","010963","ZRG1","Special Emphasis Panel ","","","02","129626","44731","174357",""
"9928359","R21","AR","5","N","05/20/2020","05/01/2020","04/30/2021","846","R21AR073947","SCHOOLS OF MEDICINE","PA-18-489","5R21AR073947-02","NIAMS:169843\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","PHILADELPHIA","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","03","002604817","US","2205901","DREXEL UNIVERSITY","PA","191021119","The proposed research is relevant to public health because it addresses gaps in our knowledge about procollagen export from the ER during fibrosis. Our goals are to understand the contribution of caspase-1 and XBP1 in the upregulation of procollagen export proteins and investigate the mechanistic role for IL-1? and TGF-?1 in this process. Our studies are relevant to the part of NIH's mission that pertains to reducing illness and disability as they would identify checkpoints in this export pathway to allow for the design of novel therapeutics that target fibrosis.","2200102; ","ARTLETT, CAROL M;","PARK, HEIYOUNG","06/01/2019","04/30/2021","Address; Binding Proteins; Biogenesis; Biological; Capsid Proteins; CASP1 gene; Caspase; Cell Line; clinical development; clinically relevant; Collagen; cytokine; Dependence; design; Development; Diffuse Scleroderma; disability; Disease; Drosophila genus; Endoplasmic Reticulum; Etiology; Event; experimental study; FDA approved; Fibroblasts; Fibrosis; Foundations; Generations; Genes; Goals; Human; inhibitor/antagonist; innovation; Integral Membrane Protein; Interleukin-1; Interleukin-1 beta; Intracellular Transport; Knowledge; Laboratories; Lead; macromolecule; Medical; Mission; Molecular; Myofibroblast; new therapeutic target; novel therapeutics; Nuclear; Outcome; Pathologic; Pathologic Processes; Pathway interactions; Patients; Pattern; Pharmaceutical Preparations; Process; Procollagen; Production; Protein Export Pathway; Protein Secretion; Proteins; Public Health; Reporting; Research; RNA Splicing; Role; Scientist; Scleroderma; Series; Site; Systemic Scleroderma; Testing; Therapeutic; therapeutic target; Time; Transcript; transcription factor; Type I Procollagen; United States National Institutes of Health; Up-Regulation; Vesicle; Work; XBP1 gene; ","Defining the mechanism of procollagen I export from the endoplasmic reticulum during fibrosis","073947","ACTS","Arthritis, Connective Tissue and Skin Study Section ","","","02","110000","59843","169843",""
"9926283","R01","GM","5","N","05/22/2020","05/01/2020","04/30/2021","859","R01GM128336","SCHOOLS OF ARTS AND SCIENCES","PA-16-160","5R01GM128336-03","NIGMS:313904\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","Nashville","UNITED STATES","BIOLOGY","05","965717143","US","8721001","VANDERBILT UNIVERSITY","TN","37203","Project Narrative This project focuses on the role of olfaction and, specifically, odorant receptors in modulating caste/colony- specific aggression in two species of highly social ants?the Florida Carpenter Ant, Camponotus floridanus and the Indian Jumping Ant, Harpegnathos saltator. In particular, we will assess how odorant receptors drive the alterations of chemosensory acuity that underlie caste/colony identity and their role in driving the social behaviors associated with social hierarchy?most notably aggression. These studies represent a valuable new model for similar human-related behavioral questions.","1911555; ","ZWIEBEL, LAURENCE J;","SESMA, MICHAEL A","08/16/2018","04/30/2022","Adult; Aggressive behavior; Animal Model; Animals; Ants; Automobile Driving; base; Behavior; Behavioral; Behavioral Model; Behavioral Paradigm; behavioral plasticity; Behavioral Research; behavioral response; behavioral study; bioinformatics pipeline; Biological Assay; Biological Models; Brain; Castes; Chemicals; Clustered Regularly Interspaced Short Palindromic Repeats; Collection; Communication; Complex; Data Set; Drosophila melanogaster; Economics; Ethics; Exhibits; Family; Female; Florida; gain of function; Gene Targeting; Gland; Hemolymph; Human; human model; Hydrocarbons; Individual; Insecta; Knock-out; Light; Link; loss of function; male; Mammals; Mediating; Messenger RNA; Modeling; Molecular; mutant; Neuraxis; Neurobiology; neurogenetics; Neuronal Plasticity; neuropeptide F; Neuropeptides; Odorant Receptors; Olfactory Pathways; Pathway interactions; Pattern; Peripheral; Pheromone; Pheromone Receptors; Police; Primates; programs; Proteomics; Publishing; receptor; reproductive; Research; response; RNA Interference; Role; Smell Perception; social; Social Behavior; Social Hierarchy; Social status; Sterility; synthetic peptide; System; Tachykinin; Testing; transcriptome sequencing; transcriptomics; Transgenic Organisms; Triad Acrylic Resin; ","Molecular Neurogenetics of Olfactory Driven Aggression and Social Hierarchy in a Model Insect System","128336","MNG","Molecular Neurogenetics Study Section ","","","03","200000","113904","313904",""
"9912024","F31","HG","1","N","01/24/2020","01/24/2020","01/23/2021","172","F31HG010999","BIOMED ENGR/COL ENGR/ENGR STA","PA-19-195","1F31HG010999-01","NHGRI:38109\","TRAINING, INDIVIDUAL","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","SANTA CRUZ","UNITED STATES","ENGINEERING (ALL TYPES)","20","125084723","US","577510","UNIVERSITY OF CALIFORNIA SANTA CRUZ","CA","950641077","Project Narrative Understanding the functional outcomes of adenosine-to-inosine (A-to-I) RNA editing in greater depth is crucial to understanding cancer, diseases of the brain, and other deleterious effects that arise from modification misregulation. To study inosines in full-length mRNA contexts, we will use nanopore sequencing to generate a map of A-to-I editing in diseased and non-diseased transcriptomes. The objective of this proposal is to develop the experimental and computational requisites for identifying inosine modifications in nanopore native RNA sequencing data, particularly for illuminating the interplay between A-to-I editing, alternative splicing, and mRNA regulation.","15025697; ","TANG, ALISON ;","GATLIN, TINA L","01/24/2020","01/23/2023","Address; Adenosine; adenosine deaminase; Affect; Alternative Splicing; Amino Acids; Atlases; base; Base Sequence; Benchmarking; Biology; Blood; Brain; Brain Diseases; Breast; career; Cell Line; Cells; Characteristics; Chimeric Proteins; Codon Nucleotides; Complementary DNA; Computational algorithm; Computational Biology; computer framework; Computer software; computerized tools; Computing Methodologies; cost; cost effective; Data; Data Analyses; Data Set; Databases; Detection; Disease; Disease Progression; Doctor of Philosophy; Enzymes; Exons; Functional disorder; functional outcomes; Guanosine; Human; human tissue; Inosine; insight; knock-down; Label; Learning; learning strategy; Length; Link; Literature; Lung; Lung Adenocarcinoma; Machine Learning; Malignant Neoplasms; Maps; Measures; Mediating; Messenger RNA; Methods; Modeling; Modification; Motor Neurons; mRNA Precursor; nanopore; neuron loss; Neurons; Normal tissue morphology; Nucleotides; Pattern; Permeability; Poly(A) Tail; Polyadenylation; Polymerase; Positioning Attribute; Property; Protein Isoforms; Regulation; Research Personnel; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Editing; RNA Processing; RNA Splicing; Role; Science; Signal Transduction; Site; skills; software development; Structure; success; System; Techniques; Testing; Time; Tissues; tool; Training; Transcript; transcriptome; transcriptome sequencing; Work; ","Platform for transcriptome-wide RNA modification identification in long reads","010999","ZRG1","Special Emphasis Panel ","","","01","38109","","38109",""
"10168886","UG4","LM","5","N","05/21/2020","05/01/2020","04/30/2021","","UG4LM012340","","RFA-LM-15-003","5UG4LM012340-05","NLM:391153\","OTHERS","2020","NATIONAL LIBRARY OF MEDICINE","","BALTIMORE","UNITED STATES","","07","188435911","US","820104","UNIVERSITY OF MARYLAND BALTIMORE","MD","212011508","","10573257; ","TOOEY, MARY JOAN;","VANBIERVLIET, ALAN","","","","AOU CE ADMIN SUPPLEMENT","012340","ZLM1","Special Emphasis Panel ","9368","","05","279595","111558","","391153"
"10041895","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI153985","","PA-19-053","1R21AI153985-01","NIAID:248773\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","PROJECT NARRATIVE Many bacteria dwelling in the gut produce special stress-resistant structures called spores. We will study how the spores of gut commensal bacteria contribute to regulating immunity and protecting against colitis and colon cancer. The knowledge learned from this research will help develop new treatments for chronic inflammatory diseases, cancers, and infections in the intestine.","8304456; ","PARK, JIN MO ;","ROTHERMEL, ANNETTE L","05/22/2020","04/30/2022","16S ribosomal RNA sequencing; Acute; Anthrax disease; Applications Grants; Bacillus anthracis; Bacillus anthracis spore; Bacteria; Bacterial RNA; Bacterial Spores; base; Bioinformatics; Biological Assay; Cell Wall; Cells; Chronic; Colitis; Colon Carcinoma; commensal bacteria; Complementary DNA; Data; Disease; Enteral; Etiology; Firmicutes; Foundations; genetic signature; Genomic DNA; gut metagenome; gut microbiome; gut microbiota; Health Promotion; Homeostasis; Human; IFNAR1 gene; Immune; Immune response; Immune system; Immunity; immunoregulation; In Vitro; Infection; Inflammation; Inflammatory; Inflammatory Response; Interferon Type I; Interferons; Interleukin-1; Intestinal Mucosa; Intestines; Investigation; Knockout Mice; Knowledge; Label; Link; Malignant Neoplasms; Mediating; Messenger RNA; Metagenomics; microbiota; Modeling; Mucous Membrane; Mus; neutrophil; novel; pathogenic bacteria; Pathogenicity; Pathology; Phylogenetic Analysis; Physiology; Play; Production; Property; protective effect; Proteins; Protocols documentation; receptor; Reproduction spores; Research; Research Project Grants; Resistance; response; Ribosomal RNA; RNA; Role; Sampling; sensor; Severities; Signal Transduction; Sorting - Cell Movement; Stress; Structure; Tissues; TLR2 gene; TLR7 gene; Toll-like receptors; Transfer RNA; transmission process; Transplantation; Virus Diseases; ","Immune responses to commensal bacterial spores in the intestinal mucosa","153985","GMPB","Gastrointestinal Mucosal Pathobiology Study Section ","","","01","150000","98773","248773",""
"9954155","R21","MH","5","N","05/19/2020","04/01/2020","03/31/2021","242","R21MH118543","EARTH SCIENCES/RESOURCES","PAR-17-310","5R21MH118543-02","NIMH:222781\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","RIVERSIDE","UNITED STATES","BIOCHEMISTRY","41","627797426","US","577506","UNIVERSITY OF CALIFORNIA RIVERSIDE","CA","925210001","PROJECT NARRATIVE Alternative splicing of microexons constitutes a functionally tightly coordinated program of post- transcripitonal events that is misregulated in a significant proportion of patients with autism spectrum disorders. This project will combine biochemical and genetic approaches to investigate the biological roles and molecular activity of the PRDM10 e8 microexon, a novel and critical regulator of neurogenesis. Results will provide mechanistic insights into the microexon- mediated control of neurogenesis and synaptic transmission, with a significant potential to better understand the function of the microexon program in the nervous system.","10419004; ","MURN, JERNEJ ;","BEER, REBECCA LYNN","06/13/2019","03/31/2021","Alternative Splicing; Amino Acids; autism spectrum disorder; autistic behaviour; axon guidance; Back; Biochemical Genetics; Biological; Brain Diseases; Calcium; Chromatin; Complex; Defect; design; Development; Disease; Event; Exhibits; Exons; Gene Expression Regulation; Genes; genetic approach; genetic element; Genetic Transcription; Genome; Genomic approach; Goals; histone methyltransferase; Human; human disease; Image; Immediate-Early Genes; induced pluripotent stem cell; insight; Investigation; Light; Link; Measures; Mediating; Molecular; Molecular Biology; Mus; nervous system disorder; Nervous system structure; neurodevelopment; Neurodevelopmental Disorder; neurogenesis; neuron development; Neuronal Differentiation; Neurons; neuroregulation; novel; Nucleotides; optogenetics; Pathogenesis; Patients; Peptides; Phenotype; Physiological; Play; Population; Post-Transcriptional Regulation; postsynaptic neurons; Process; programs; Property; protein function; Protein Isoforms; Proteins; Proteomics; Regulation; relating to nervous system; Resources; response; RNA interference screen; RNA Splicing; Role; screening; Signal Transduction; Surveys; Synapses; synaptic function; Synaptic Transmission; synaptogenesis; Testing; tool; transcription factor; Transcription Process; ","Investigating the functional landscape of the PRDM10 microexon in neuronal development","118543","ZRG1","Special Emphasis Panel ","","","02","150000","72781","222781",""
"10082908","R21","AI","1","N","05/20/2020","05/20/2020","04/30/2021","855","R21AI152826","","PA-19-053","1R21AI152826-01A1","NIAID:251500\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BRONX","UNITED STATES","","14","081266487","US","10053556","ALBERT EINSTEIN COLLEGE OF MEDICINE","NY","104611900","HIV-1 remains hidden in a latent state in T cells of infected individuals. Such latently infected cells need to be eliminated by a ?wake and Kill? approach, however, it has not been possible to wake all the latent cells because of the cell-to-cell variability in reactivation. This application employs sophisticated single cell single molecule procedures, a high speed and high resolution scanning technology and single cell RNA sequencing method to study the molecular roadblocks to ?waking? latent HIV on a cell-to-cell basis.","1891677; ","KALPANA, GANJAM V;","MCDONALD, DAVID JOSEPH","05/20/2020","04/30/2022","Antibodies; base; Biological Assay; CD4 Positive T Lymphocytes; Cell Culture Techniques; cell type; Cells; combat; Computational algorithm; Data; Development; differential expression; epigenetic regulation; Fishes; Gene Expression Regulation; Genes; Genetic; Genetic Heterogeneity; Genetic Transcription; Goals; HIV; HIV-1; Image; Immunofluorescence Immunologic; in vivo; Individual; Infection; innovation; integration site; knock-down; Lead; Length; Methodology; Methods; Microscopy; Modeling; Molecular; multiple omics; new therapeutic target; Noise; novel; novel marker; novel therapeutics; Pathway interactions; Patients; Procedures; Proteins; Proviruses; Quantitative Reverse Transcriptase PCR; reactivation from latency; Resolution; Rest; RNA; RNA Probes; Sampling; Scanning; Shock; single cell analysis; single molecule; single-cell RNA sequencing; Site; Slide; Source; Speed; Stimulus; T-Lymphocyte; Techniques; Technology; Transcript; transcriptome; transcriptome sequencing; Variant; Viral; Viral Genome; Viral Proteins; viral RNA; Virus Integration; ","Single cell RNA-seq and single molecule RNA-FISH approaches to study stochasticity of latent  HIV-1 reactivation","152826","HVCD","HIV Molecular Virology, Cell Biology, and Drug Development Study Section ","","A1","01","150000","101500","251500",""
"9921226","U54","MD","5","N","05/18/2020","04/01/2020","03/31/2021","","U54MD010722","","RFA-MD-15-013","5U54MD010722-05","NIMHD:135494\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","Project Narrative  While it is widely recognized that a host of common diseases and disease outcomes differ  among populations defined by continental ancestry, it is usually unclear what the relative  contributions of different patterns of environmental exposures, different access to and utilization  of health care resources, and the different frequencies of alleles affecting risk of disease or  outcomes are to the observed differences in risk of disease and outcomes. We focus in this  project largely on building tools to identify and characterize, with respect to function and  biological mechanism, the genetic risk factors contributing to health disparities in disease and  outcomes, and then in the application of these tools to disease and outcome phenotypes  relevant to our project and to the larger health disparities research community.  The goals of this project are to 1) build resources that make it easier to identify the genetic  component to observed health disparities in disease risk and/or outcomes and 2)  investigate some specific health disparities in which genetic risk factors clearly  contribute to differences between continental population in lifetime risk of the phenotype of  interest.","3075104; ","COX, NANCY J;","","","","Academic Medical Centers; Affect; African; African American; American; Asthma; Back; base; biobank; Biological; Child; Clinical; Clinical Data; clinical data warehouse; Communities; Data; Databases; Demographic Factors; design; Disease; Disease Outcome; disease phenotype; disorder risk; DNA; Electronic Health Record; Environment; Environmental Exposure; European; Funding; Future; Gene Frequency; Genetic; genetic risk factor; Genome; genome sequencing; genome wide association study; Genotype; Geography; Goals; Grant; health care service utilization; health disparity; Hispanics; Individual; Infrastructure; interest; Investigation; Investments; Lesbian Gay Bisexual Transgender; lifetime risk; Link; Malignant neoplasm of cervix uteri; Medicine; Methodology; Mexican Americans; novel; Outcome; Patients; Pattern; Phenotype; Population; population health; precision medicine; Premature Birth; Records; Research; Research Infrastructure; Resources; Risk; Sampling; social factors; Software Tools; tool; Universities; Variant; whole genome; ","Project 2- Using a Biobank and Electronic Health Records to Characterize Genome Variation Affecting Health Disparities","010722","ZMD1","Special Emphasis Panel ","8205","","05","105053","30441","","135494"
"10073210","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI154841","","PA-19-053","1R21AI154841-01","NIAID:261150\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","076647908","US","8961401","BENAROYA RESEARCH INST AT VIRGINIA MASON","WA","981012795","PROJECT NARRATIVE Systemic lupus erythematosus is a complex autoimmune disease characterized by the presence of circulating autoantibodies to nucleic acids and proteins with which they associate. These antibodies form immune complexes that then activate white blood cells, including plasmacytoid dendritic cells that are important in lupus disease. In this proposal, we investigate how different autoantibody types contribute to immune complexes, activation of plasmacytoid dendritic cells, and lupus disease.","8662242; ","HAMERMAN, JESSICA A;","JOHNSON, DAVID R","05/22/2020","04/30/2022","Antibodies; Antigen-Antibody Complex; Antigens; Antinuclear Antibodies; Autoantibodies; Autoantigens; Autoimmune Diseases; Autoimmune Responses; Binding; CD32 Antigens; Cells; Complex; cytokine; Dendritic cell activation; Dendritic Cells; Deposition; Development; Disease; disease registry; Endosomes; experimental study; Fc Receptor; Fc(alpha) receptor; Future; Human; human data; IgA receptor; IgE; Immune; immune activation; Immune response; Immunoglobulin A; Immunoglobulin G; Interferon-alpha; Interferons; Leukocytes; Lupus; Mediating; novel; Nucleic Acid Binding; Nucleic Acids; Organ; Pathogenesis; Pathologic; Patients; Plasma Cells; pleiotropism; Production; Proteins; Reagent; receptor binding; repository; Research Institute; Research Project Grants; response; Role; Sampling; Serum; Signal Transduction; stoichiometry; synergism; Systemic Lupus Erythematosus; T cell response; Testing; TLR7 gene; Toll-like receptors; uptake; ","IgA-containing immune complexes in plasmacytoid dendritic cell activation in SLE","154841","HAI","Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section ","","","01","150000","111150","261150",""
"9937162","P01","AG","2","N","05/22/2020","04/01/2020","03/31/2021","","P01AG002132","","PAR-18-297","2P01AG002132-39","NIA:241389\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","1864561; ","CARLSON, GEORGE A.;","","","","age effect; aged; Aging; Alleles; Alzheimer's Disease; Amyloid beta-Protein; animal care; Animal Experiments; animal facility; Animal Model; Animal Technicians; Animals; Apolipoprotein E; base; Biochemical; Biological Assay; Bioluminescence; biophysical analysis; Biophysics; Brain; Breeding; Caring; Cell Culture Techniques; Cellular Assay; Clinical; Coupled; Cryoelectron Microscopy; Cryopreservation; Data; design; Development; Diagnosis; Disease; disease diagnosis; Disease Marker; Disease Progression; endonuclease; Environment; experimental study; Fingerprint; fluorescence imaging; genetic risk factor; Genotype; Gliosis; Harvest; Human; human disease; in vitro Bioassay; in vivo; Measurement; Mediating; Methodology; Microinjections; Modeling; Molecular Conformation; Monitor; Mus; mutant; Mutation; Neurodegenerative Disorders; novel; Onset of illness; overexpression; Pathologic; Patients; Peptides; prevent; Prion Diseases; Prions; Production; programs; Property; Proteins; Rattus; Research; Research Personnel; Resolution; Rodent; Rodent Model; Sampling; Services; Shapes; Source; Structure; tau aggregation; tau Proteins; Tauopathies; Testing; Time; Tissue Banks; Transgenic Mice; Transgenic Model; Transgenic Organisms; transmission process; Validation; ","Core C: Animals","002132","ZAG1","Special Emphasis Panel ","6193","","39","149544","91845","","241389"
"10011475","R41","ES","1","N","05/20/2020","05/20/2020","04/30/2021","113","R41ES031043","","PA-19-270","1R41ES031043-01A1","NIEHS:225000\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","Los Angeles","UNITED STATES","","34","080908363","US","10050157","ENSPIRE BIO, INC.","CA","900713301","Narrative Impaired mitochondrial function has been shown to contribute to development and progression of various diseases. There is an unmet need to clinically monitor mitochondrial function; however, until now this has been impossible due to the requirement of immediate processing of living tissue samples. We have developed a new technology to measure mitochondrial function in previously frozen samples, which, for the first time, opens up the possibility of clinical monitoring of mitochondrial function in large population.","7035646; 15480314 (contact); ","SHIRIHAI, ORIAN S; WANG, AMY  (contact);","SHAUGHNESSY, DANIEL","05/20/2020","04/30/2021","Academia; Acute; Aging; Biocompatible Materials; Biological; Biological Assay; Biotechnology; Cardiovascular system; Cells; Client; Clinical; clinical application; clinical development; clinical practice; Clinical Research; clinically relevant; Communities; Complex; Data; Development; Disease; Drug Exposure; Economics; Environment; Environmental Monitoring; environmental toxicology; Evaluation; Feedback; Freezing; Future; Genetic Models; Goals; Hour; Human; Impairment; improved; Industry; Instruction; Legal patent; Measurement; Measures; Metabolic; Methodology; Methods; minimally invasive; Mitochondria; Mitochondrial Diseases; Monitor; Mus; new technology; Organizational Models; Outcome; Oxygen Consumption; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Play; Population; Positioning Attribute; Preparation; Procedures; Protocols documentation; Reagent; Reproducibility; Research; Research Contracts; Research Personnel; Respiration; respiratory; Respiratory physiology; Running; Sampling; Services; Ships; Side; Site; Swab; Technology; Technology Assessment; Testing; Time; Tissue Sample; Tissues; toxicant; Toxicant exposure; Toxicology; United States Food and Drug Administration; ","MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES","031043","ZRG1","Special Emphasis Panel ","","A1","01","","","225000",""
"9933898","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:122300\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","8820024; ","BRISSOVA, MARCELA ;","","","","Abbreviations; Academic Medical Centers; Aging; Area; base; Beta Cell; Biological Assay; Biology; cell type; Cells; Complex; Constitution; Core Facility; Data; data standards; Databases; Development; Diabetes Mellitus; Disease; Effectiveness; falls; Funding; Genetic; Health; high resolution imaging; Homeostasis; Hormone secretion; Hormones; Human; human tissue; Imaging technology; Immunology; Infrastructure; Insulin-Dependent Diabetes Mellitus; International; islet; Islets of Langerhans; Islets of Langerhans Transplantation; Maintenance; Measurement; member; metabolic phenotype; Molecular; Molecular Abnormality; Morphology; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; novel; Output; Pancreas; Physiological; Preparation; Price; Procedures; Process; programs; Publishing; Quality Control; Reporting; Reproducibility; Research; Research Personnel; Research Training; Resources; response; Rodent; Services; Signal Transduction; Standardization; Stress; success; System; Techniques; Time; Tissue imaging; transcription factor; whole slide imaging; ","Islet Procurement and Analysis Core","020593","ZDK1","Special Emphasis Panel ","7650","","43","77405","44895","","122300"
"10065060","R01","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R01AI154598","","PA-18-859","1R01AI154598-01","NIAID:515015\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ROCHESTER","UNITED STATES","","01","006471700","US","4976101","MAYO CLINIC ROCHESTER","MN","559050001","Narrative The goal of this proposal is to dissect the roles of tissue-resident CD4 helper T cells in the development of protective mucosal immunity following influenza infection or immunization with a ?universal? influenza vaccine candidate, Nanovax. In addition, this application is designed to use genetic approaches to test whether selective promotion of tissue-resident helper T cell responses will simultaneously boost mucosal memory B cell and T cell responses following influenza infection or after immunization with Nanovax.","10516319; ","SUN, JIE ;","LANE, MARY CHELSEA","05/21/2020","04/30/2025","Ablation; Address; Antigen Presentation; ATAC-seq; B-Lymphocytes; base; BCL6 gene; CD4 Positive T Lymphocytes; CD8-Positive T-Lymphocytes; CD8B1 gene; Cell Maintenance; Cells; Cellular Immunity; Cessation of life; Chronic; Cues; cytokine; Data; design; Development; Epigenetic Process; Epitopes; Evolution; Exhibits; Future; Gene Expression; Gene Proteins; Generations; genetic approach; genetic profiling; Goals; Helper-Inducer T-Lymphocyte; Humoral Immunities; Hybrids; Immune response; Immunity; Immunization; In Situ; Influenza; Influenza A virus; Influenza Therapeutic; Influenza vaccination; influenza virus strain; influenzavirus; Invaded; Lung; Maintenance; Mediating; Memory; Memory B-Lymphocyte; migration; Molecular; Mucosal Immunity; mucosal site; mucosal vaccination; mucosal vaccine; Mucous Membrane; novel; pathogen; Pathway interactions; Plasma; Population; Property; protein expression; Respiratory Mucosa; Respiratory System; response; Role; secondary infection; secondary lymphoid organ; Shapes; Structure of germinal center of lymph node; Structure of parenchyma of lung; T cell response; T-Lymphocyte; Testing; Therapeutic; Tissues; transcription factor; transcriptome sequencing; universal influenza vaccine; universal vaccine; vaccine candidate; Viral; Virus; Virus Diseases; ","Roles of tissue-resident helper T cells in mucosal immunity against influenza infection","154598","ZRG1","Special Emphasis Panel ","","","01","323909","191106","515015",""
"9940319","R01","HL","1","N","05/19/2020","05/19/2020","03/31/2021","837","R01HL151407","SCHOOLS OF MEDICINE","PA-19-056","1R01HL151407-01","NHLBI:352300\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","JACKSON","UNITED STATES","EMERGENCY MEDICINE","03","928824473","US","5390304","UNIVERSITY OF MISSISSIPPI MED CTR","MS","392164500","Narrative  Despite its position as a leading cause of maternal death and major contributor to maternal and perinatal morbidity, there is no effective drug treatment to prevent preeclampsia (PE). At present, the only effective treatment for PE is early delivery of the baby and placenta. Based on recent studies and on preliminary data presented in this application, we propose that the NLRP3 inflammasome is a novel therapeutic target for the treatment of PE.","11535895; ","CORNELIUS, DENISE CRESHUN;","VARAGIC, JASMINA","05/19/2020","03/31/2025","Adaptor Signaling Protein; Address; Affect; Animal Model; Attenuated; base; Binding; Binding Proteins; Biochemical; Blood Pressure; Blood Vessels; CASP1 gene; Cells; Cessation of life; Chronic; Clinical Research; Complement; Complex; cytokine; Data; effective therapy; Enzymes; Etiology; Event; fetal; Fetal Growth Retardation; Fetal Weight; Goals; Hypertension; hypoperfusion; Immune; immune activation; Immune system; Immune System Diseases; Immunologic Factors; Impairment; improved; in vivo; Inflammasome; Inflammation; Infusion procedures; inhibitor/antagonist; Interleukin-1; Interleukin-1 beta; Ischemia; kidney dysfunction; Knowledge; Lead; Link; maternal hypertension; maternal morbidity; Maternal Mortality; Mediating; Modeling; Molecular; Morbidity - disease rate; Natural Killer Cells; new therapeutic target; NK Cell Activation; novel; novel therapeutic intervention; novel therapeutics; Nucleotides; Pathogenesis; pathophysiology of preeclampsia; Pathway interactions; Perfusion; perinatal morbidity; Pharmacology; Pharmacotherapy; Physiological; Placenta; polarized cell; Positioning Attribute; Pre-Eclampsia; Pregnancy; pregnant; Pregnant Women; pressure; prevent; Production; protein expression; Rattus; receptor; Renal function; Reporting; Research; response; Role; Signal Transduction; Techniques; Testing; therapeutic target; Uterus; Vascular Diseases; Woman; ","Hypertension, Inflammation, and Vascular Function","151407","HM","Hypertension and Microcirculation Study Section ","","","01","250000","102300","352300",""
"9942158","R01","MH","1","N","05/18/2020","05/18/2020","02/28/2021","242","R01MH122544","","PAR-18-904","1R01MH122544-01","NIMH:318304\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","STOCKHOLM","SWEDEN","","","350582235","SW","4216101","KAROLINSKA INSTITUTE","","171 77","Project Narrative The personal, familial, and societal costs of schizophrenia and bipolar disorder are enormous. This study will use Swedish population-level data across the lifespan to explore shared and divergent environmental risk factors for schizophrenia and bipolar disorder and their relationships to inherited risk factors - both familial risk and molecular genetic risk. Through these studies, we will derive a more comprehensive understanding of the influences leading to schizophrenia and bipolar disorder diagnoses which will lead to new opportunities for prevention tactics and treatment options.","9798298; ","BERGEN, SARAH E;","GITIK, MIRI","05/18/2020","02/29/2024","Address; Affect; Age of Onset; Attention; base; Bipolar Disorder; Birth; childhood adversity; Clinical; comparative; Data; Development; Diagnosis; Disease; disorder risk; Environmental Exposure; Environmental Impact; Environmental Risk Factor; Etiology; Family; Family history of; Foundations; Genes; Genetic; genetic architecture; Genetic Risk; genetic risk assessment; genetic risk factor; Genotype; Heritability; indexing; Individual; Infection; informant; Inherited; Investigation; Longevity; marijuana use; Measures; migration; Molecular Genetics; novel; obstetrical complication; Pathway interactions; personal narratives; Population; Prevention; Prevention strategy; Public Health; Recording of previous events; Registries; Reporting; Research; Resources; Risk; Risk Factors; Role; Sampling; Scandinavian; Schizophrenia; severe psychiatric disorder; Shapes; Single Nucleotide Polymorphism; societal costs; Sweden; Testing; therapeutic target; Work; ","A comparison of environmental and genetic risks for schizophrenia and bipolar disorder: A Swedish national study","122544","BGES","Behavioral Genetics and Epidemiology Study Section ","","","01","296885","21419","318304",""
"9927568","UC7","AI","5","N","05/19/2020","05/01/2020","04/30/2021","","UC7AI094660","","RFA-AI-15-009","5UC7AI094660-10","NIAID:673879\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","GALVESTON","UNITED STATES","","14","800771149","US","578406","UNIVERSITY OF TEXAS MED BR GALVESTON","TX","775555302","National Biocontainment Laboratories Operational Support ensures the availability of maximum containment laboratories for research that will develop the next generation of therapeutics, diagnostics and vaccines for infectious diseases that can pose a public health risk. It also ensures that high containment labs are available in the event of a public health or bioterrorism emergency. This support is essential due to the high cost of building and maintaining laboratories that protect researchers, ensure the biosecurity of dangerous pathogens, and safeguard the communities where these laboratories are located.","7942185; ","BEASLEY, DAVID ;","","","","biodefense; biosecurity; Bioterrorism; Communicable Diseases; Communities; Containment; cost; Dangerousness; Diagnostic; Emergency Situation; Ensure; Environmental Health; Event; Funding; Goals; Infrastructure; Laboratories; Laboratory Research; Lead; Maintenance; Medical; National Institute of Allergy and Infectious Disease; novel therapeutics; operation; pathogen; pre-clinical; product development; Public Health; public health emergency; Regulation; Research; research facility; Research Personnel; Resources; Risk; Services; System; Texas; Training and Education; United States National Institutes of Health; Universities; Vaccines; ","Regulatory Compliance Core - Galveston National Laboratory BSL4 Operations","094660","ZAI1","Special Emphasis Panel ","8723","","10","436546","237333","","673879"
"9933889","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","847","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:1772398\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","Center Overview: Project Narrative The Vanderbilt Diabetes Research and Training Center is working to understand why diabetes develops, how it can be prevented, and how diabetes treatment can be improved.","1878595; ","POWERS, ALVIN C;","HYDE, JAMES F","12/01/1996","03/31/2022","Abbreviations; Academic Medical Centers; acronyms; Address; American; Applications Grants; Area; base; Basic Science; Beta Cell; Biomedical Research; burden of illness; career development; Cellular biology; Clinical Research; college; Communities; Complications of Diabetes Mellitus; Development; Diabetes Mellitus; Digestive System Disorders; Endocrinology; Engineering; Ensure; Environment; Etiology; Evolution; experience; Faculty; Fostering; Funding; Genetic; Goals; graduate student; Grant; Human; improved; Infrastructure; innovation; Institutes; Institution; Insulin-Dependent Diabetes Mellitus; Interdisciplinary Study; Investments; islet; Knowledge; medical schools; Medical Students; member; metabolic phenotype; Metabolism; Mission; Molecular; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; operation; organizational structure; outreach; outreach program; Patient Care; Postdoctoral Fellow; prevent; Prevention; programs; Public Health; recruit; Research; Research Personnel; Research Training; Resource Sharing; Resources; Schools; scientific organization; Scientist; Series; Services; skills; Supervision; Training; Training and Education; Training Programs; Training Support; Translating; Translational Research; Translations; United States National Institutes of Health; ","Vanderbilt Diabetes Research and Training Center","020593","ZDK1","Special Emphasis Panel ","","","43","1275372","497026","1772398",""
"10038454","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI153475","SCHOOLS OF VETERINARY MEDICINE","PA-19-053","1R21AI153475-01","NIAID:206568\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","MADISON","UNITED STATES","PATHOLOGY","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","PROJECT NARRATIVE Filoviruses, which include Ebola viruses, are the causative agents of severe and frequently lethal human diseases. Our proposed studies will generate an Ebola VP30 transgenic mouse model that supports the replication of an established replication-defective Ebola virus. This new animal model will offer a means to perform efficient and safe studies outside of BSL-4 containment to tackle many of the questions that remain unanswered regarding filovirus pathogenesis and to evaluate countermeasures against filoviruses.","1864866; ","KAWAOKA, YOSHIHIRO ;","DUPUY, LESLEY CONRAD","05/22/2020","04/30/2022","African; Animal Model; Antiviral Agents; base; beta Actin; Biological; Breeding; Bundibugyo virus; Case Fatality Rates; Cell Culture Techniques; cell type; Cells; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chickens; China; Chiroptera; Collaborations; Containment; cost; Defective Viruses; Democratic Republic of the Congo; Dendritic Cells; Development; Disease; Disease Outbreaks; disease phenotype; Disseminated Intravascular Coagulation; Ebola; Ebola virus; Engineering; Evaluation; Failure; Family; Fibroblasts; Filovirus; forest; Future; Genome; genome editing; Glycoproteins; Goals; Growth; Guinea; Hematopoietic; Histopathology; Human; human disease; Immune response; Immunologics; In Vitro; in vivo; Infection; insight; Kenya; Kinetics; Knock-in; Laboratories; Laboratory Research; Life Cycle Stages; Liver; macrophage; member; Messenger RNA; Modeling; monocyte; Morphology; mouse model; Mus; Nature; Organ; Pathogenesis; pathogenic virus; Pathogenicity; Phenotype; promoter; Property; Proteins; PTPRC gene; Public Health; Regulation; Research; research and development; Research Personnel; Resistance; Reston Ebola virus; Risk; safety testing; Science Policy; Sierra Leone; Spain; stable cell line; Sudan Ebola virus; System; Tail; Therapeutic; Therapeutic Agents; therapeutic vaccine; Time; Training; Transgenic Animals; Transgenic Mice; Transgenic Organisms; United States National Institutes of Health; Universities; Vaccines; Viral; Viral Genes; Viral Genome; Virulence Factors; Virus; Virus Replication; Wild Type Mouse; Wisconsin; Zaire Ebola virus; ","A Transgenic Mouse Model to Study Ebolaviruses and other Filoviruses","153475","VIRB","Virology - B Study Section ","","","01","150000","56568","206568",""
"10166916","I01","VA","5","N","05/18/2020","07/01/2019","09/30/2019","999","I01HX001589","","RFA-HX-14-014","5I01HX001589-05","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","INDIANAPOLIS","UNITED STATES","","07","608434697","US","481029","RLR VA MEDICAL CENTER","IN","462022803","Chronic pain affects approximately 100 million Americans and 40-70% of Veterans. Pain is costly, disabling, and exerts an appreciable negative impact on these Veterans' lives. Pain self-management is an important component of chronic pain treatment, and is at the foundation of VHA's 2009 Pain Directive. However, providing pain self- management instruction to Veterans is time-consuming and resource intensive, especially when Veterans require motivational and emotional support. ECLIPSE is a randomized controlled trial that tests a novel approach to pain self-management: a peer coaching model, in which Veterans with chronic pain offer information, support, and mentorship to other Veterans.","10043921; ","MATTHIAS, MARIANNE ;","","07/01/2015","09/30/2019","Advocate; Affect; American; arm; Behavioral; Brief Pain Inventory; Caring; Chronic; chronic musculoskeletal pain; chronic pain; Clinic; Complement; Consumption; coping; Coping Skills; cost; disability; Education; Effectiveness; Emotional; emotional distress; Enrollment; Evaluation; Evidence based treatment; experience; Family; Foundations; Funding; Goals; health care service utilization; health related quality of life; health service use; Healthcare; Hour; Hybrids; improved; innovation; Institute of Medicine (U.S.); Instruction; Intervention; intervention cost; Interview; Life; Manuals; Measures; Medical Care Costs; Medical Care Team; Mentorship; Methods; Modeling; Motivation; novel; novel strategies; Nurses; Opioid Analgesics; Outcome; Outcome Study; Pain; Pain intensity; Pain interference; Pain management; pain reduction; pain self-management; pain symptom; Participant; Patients; peer; peer coaching; peer support; Persons; Pharmacological Treatment; primary endpoint; Primary Health Care; Productivity; programs; Protocols documentation; Quality of life; Randomized; Randomized Controlled Trials; recruit; Research Design; Resources; secondary outcome; Self Efficacy; Self Management; self-management program; social; Social support; Supervision; Telephone; Testing; Time; TimeLine; Training; treatment adherence; trial design; Veterans; Visit; Work; ","Evaluation of peer Coach-Led Intervention to improve Pain Symptoms (ECLIPSE)","001589","HSR2","HSR-2 Determinants of Patient Response to Care   ","","","05","","","",""
"9964680","U54","CA","5","N","05/18/2020","05/01/2020","04/30/2021","","U54CA209988","","RFA-CA-15-014","5U54CA209988-04","NCI:404624\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","1938469; ","SEARS, ROSALIE C;","","","","Address; Aftercare; analytical method; ATAC-seq; Automobile Driving; Bar Codes; base; Breast Cancer Cell; Breast Cancer cell line; cancer cell; Cell model; Cell physiology; Cells; Cessation of life; clinically relevant; Clonal Expansion; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; combinatorial; Combined Modality Therapy; computer framework; Computer Models; Data; Dependence; differential expression; Disease; Disease Progression; Disease Resistance; Drug Combinations; drug efficacy; Drug resistance; Epigenetic Process; epigenetic regulation; Event; experimental study; Genetic; Genotype; Goals; Heterogeneity; Image; Image Cytometry; In Vitro; in vivo; inhibitor/antagonist; Libraries; Link; live cell imaging; malignant breast neoplasm; Malignant Neoplasms; Maps; Measures; Mediating; Mesenchymal; Mesenchymal Differentiation; Metadata; Modeling; Molecular; molecular modeling; neoplastic cell; novel therapeutics; Oncogenic; Outcome; outreach; Pathway interactions; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Phenotype; Population; population based; Population Heterogeneity; prevent; Proteins; Recurrence; Regulation; Regulatory Element; Residual state; Resistance; response; Route; single-cell RNA sequencing; Systems Biology; targeted treatment; Testing; Therapeutic; therapy resistant; Time; transcriptome sequencing; Treatment Efficacy; treatment response; triple-negative invasive breast carcinoma; tumor; tumor heterogeneity; Work; Xenograft procedure; ","Therapeutic Management of Lineage- and Differentiation-state Plasticity","209988","ZCA1","Special Emphasis Panel ","8358","","04","265870","138754","","404624"
"9868870","P01","AG","5","N","05/18/2020","03/01/2020","02/28/2021","","P01AG009524","","PAR-13-258","5P01AG009524-25","NIA:246010\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","TAMPA","UNITED STATES","","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","PUBLIC HEALTH RELEVANCE NARRATIVE- Project 4 Presbycusis, or Age -Related Hearing Loss (ARHL), is the number one communication disorder and number one neurodegenerative condition of our expanding aging population; and comprises one of the top 3 chronic medical conditions, along with arthritis and cardiovascular diseases. The vast majority of people over age 60 are affected by this progressive decline in auditory sensitivity and speech understanding, which are hallmarks of ARHL. Despite this high prevalence of ARHL, there currently are no medical treatments for preventing or reversing permanent hearing loss (ARHL or other types). The thematic focus of this proposal is modulation of presbycusis through biotherapeutics and acoustic treatments. If the experiments proposed here to test hypotheses concerning interventions to modulate the progression of presbycusis are successful, the novel results should lead to clinical trials of the efficacy of these innovative technological, acoustic and drug-related treatments.","1878841; ","FRISINA, ROBERT D;","","","","Acclimatization; Acoustics; Affect; Age; age related; aged; Aging; aging auditory system; aging population; Aldosterone; Anatomy; Animal Model; Animals; Anti-Inflammatory Agents; Arthritis; Auditory; auditory processing; Auditory system; base; behavior measurement; Behavioral; Biological; Biological Markers; Biological Response Modifier Therapy; Brain; brain circuitry; Cardiovascular Diseases; Cellular Neurobiology; Chronic; Clinical; Clinical Trials; Cochlea; Communication; Communication impairment; Complex; Coupled; dosage; drug discovery; Ear; efficacy trial; Engineering; Environment; experience; experimental study; Exposure to; Eye; Funding; Goals; Health; Hearing; Hearing Aids; High Prevalence; Hormonal; hormone therapy; Hormones; Human; improved; indexing; innovation; Intervention; Investigation; Knowledge; Lead; Link; Measures; Medical; Molecular; Molecular Mechanisms of Action; Molecular Neurobiology; multidisciplinary; Mus; Nature; Nerve Degeneration; Nervous system structure; neural circuit; Neuroanatomy; Neurodegenerative Disorders; Neuronal Plasticity; novel; novel therapeutics; Outcome Measure; Pathway interactions; Performance; Peripheral; permanent hearing loss; Pharmaceutical Preparations; Pharmacology; Physiological; Play; Presbycusis; prevent; Price; public health relevance; relating to nervous system; remediation; Rodent; Sensory; Serum; Severities; sound; Speech; Sum; Supplementation; System; Testing; Therapeutic; Therapeutic Intervention; virtual; Work; ","Project 4 - Animal Neuroanatomy, Cellular and Molecular Neurobiology","009524","ZAG1","Special Emphasis Panel ","5996","","25","167932","78078","","246010"
"9926915","R01","HL","5","N","05/19/2020","05/01/2020","04/30/2021","837","R01HL139985","","PA-16-160","5R01HL139985-03","NHLBI:697210\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","SPRINGFIELD","UNITED STATES","","01","079237988; 108999004; 117007515","US","7710201","BAYSTATE MEDICAL CENTER, INC.","MA","011991001","PROJECT NARRATIVE Accountable Care Organization (ACO) enrollment is expected to expand rapidly in upcoming years, resulting in an urgent need to understand the impact that ACOs have on processes of care and outcomes for the more than 5.7 million Americans with heart failure (HF). Through statistical analyses of the records of Medicare beneficiaries with HF, qualitative interviews, and a survey of all ACOs participating in the Medicare Shared Savings Program (MSSP), we will describe the organizational strategies and contextual factors of ACOs that have improved risk-standardized outcomes for patients with HF, including acute admission rates, days in skilled nursing care, and deaths. The results of this study will inform policymakers and health system and ACO leaders as they develop and refine novel organizational strategies for improving care for patients with HF.","10328157; ","LAGU, TARA C;","HSU, LUCY L","07/15/2018","04/30/2022","Acute; Admission activity; Adult; American; base; beneficiary; burden of illness; care costs; care delivery; Care given by nurses; care outcomes; Caring; Case Manager; Cessation of life; Characteristics; Clinical Protocols; Clinical Research; contextual factors; cost; Data; disability; Disease; Diuretics; Enrollment; Ensure; experience; Feedback; Future; Goals; Health; Health Personnel; Health Policy; Health system; Healthcare; Heart failure; Heterogeneity; high risk; hospital admission rate; Hospitalization; Hospitals; implementation research; implementation strategy; improved; improved outcome; Incentives; Individual; informant; insight; Intervention; Interview; Investigation; Knowledge; Lead; Measurement; medical specialties; Medicare; Methods; Modeling; mortality; National Heart, Lung, and Blood Institute; novel; Outcome; Patient Care; Patient-Focused Outcomes; Patients; Pattern; Phenotype; Platelet Factor 4; Population; population health; Predictive Analytics; Prevalence; prevent; Primary Health Care; primary outcome; Process; programs; Provider; Quality of Care; Records; Research; Risk; Sampling; Savings; secondary outcome; Services; Skilled Nursing Facilities; Standardization; Statistical Data Interpretation; Surveys; System; Testing; Time; time use; Translational Research; trend; Variant; Work; ","Identifying effective strategies used by Medicare Accountable Care Organizations to improve outcomes for patients with heart failure: A mixed-methods study","139985","HSOD","Health Services Organization and Delivery Study Section ","","","03","512628","184582","697210",""
"10093790","R01","MH","3","N","05/18/2020","03/17/2020","05/31/2021","242","R01MH117123","","PA-18-591","3R01MH117123-02S1","NIMH:93491\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BOSTON","UNITED STATES","","07","005492160","US","3617301","BOSTON MEDICAL CENTER","MA","021182908","PROJECT NARRATIVE Sexual and gender minority (SGM) youth face significant barriers to accessing mental health services. Family Navigation (FN) holds promise as an evidence-based intervention to address these barriers, yet no data exist on the use of FN in SGM Youth. The current application proposes conducting semi-structured interviews with Community Health Workers and families with SGM youth to elucidate potential adaptations to FN that would lead to successful work with the SGM community.","11298725; 8646469 (contact); ","BRODER-FINGERT, SARABETH ; FEINBERG, EMILY  (contact);","PINTELLO, DENISE","08/01/2018","05/31/2023","Address; Award; barrier to care; Boston; care coordination; Child; Child Mental Health; Child Rearing; chronic care model; Communities; Community Health; Community Health Aides; Competence; County; Data; design; Discipline; Discrimination; disparity reduction; Distress; Effectiveness; ethnic minority population; Evaluation; evidence base; Evidence based intervention; experience; Face; Family; Future; Gender Identity; Grief reaction; health disparity; Health Personnel; Health Services Accessibility; health training; Healthcare; implementation science; Improve Access; Individual; interest; Intervention; Interview; Language; Lead; lens; Lesbian Gay Bisexual Transgender Queer; Mental disorders; Mental Health; Mental Health Services; Methods; minority communities; Minority Groups; Modeling; Modification; motivational enhancement therapy; multi-component intervention; National Institute of Mental Health; novel; Outcome; Parents; Patient Education; Patients; Plant Roots; Population; Problem Solving; Process; programs; Qualitative Methods; racial minority; randomized trial; Recommendation; Reporting; Research; Risk; Services; Sexual and Gender Minorities; sexual identity; social stigma; Structure; Substance Use Disorder; Suicide; System; Testing; Time; Training; Work; Youth; ","Adapting Family Navigation to Improve Access to Mental Health Services for LGBTQ+ Youth","117123","","","","S1","02","73680","19811","93491",""
"9918114","P30","ES","1","N","05/21/2020","05/15/2020","03/31/2021","","P30ES030284","","RFA-ES-18-003","1P30ES030284-01A1","NIEHS:467394\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","1923502; ","FUNG, JENNIFER C;","","05/22/2020","03/31/2025","Air; Animal Model; Area; base; Biological; Biological Assay; Biological Models; Biological Monitoring; Biological Process; California; Cells; Chemical Exposure; Chemical Models; Chemicals; Communities; consumer product; Core Facility; cost; cost effective; Data Analyses; data integration; Defect; Detection; Development; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Epidemiology; Equipment; Evaluation; Evolution; experimental study; Fostering; Funding; Goals; Growth; Hazardous Waste; Health; Health Professional; high throughput screening; Human; human tissue; in vivo; Individual; innovation; Investments; Ions; Laboratories; Link; Mass Spectrum Analysis; Measurement; Measures; member; Monitor; Morphology; Mus; new technology; novel; Organism; Pathway interactions; Peptides; physiologic model; Planet Earth; Poison; Procedures; programs; Proteomics; Reaction; Reproducibility; reproductive; Research; Research Design; Research Personnel; Resources; Sampling; Scientist; screening; Services; Shotguns; small molecule libraries; Soil; Specialist; Specimen; Standardization; Stream; Technical Expertise; Technology; tissue culture; Tissue Sample; tissue/cell culture; Tissues; tool; toxicant; Translations; Water; Xenograft procedure; ","Bioassay Facility Core","030284","EHS","Environmental Health Sciences Review Committee ","7074","A1","01","311809","155585","","467394"
"9858778","R01","HD","1","N","05/19/2020","05/19/2020","02/28/2021","865","R01HD100392","SCHOOLS OF MEDICINE","PAR-18-039","1R01HD100392-01","NICHD:667626\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","PITTSBURGH","UNITED STATES","PSYCHIATRY","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","8. PROJECT NARRATIVE This project proposes to develop and validate the Adult Functioning Scale, a self- and caregiver-report assessment of social, employment, and independent living domains suitable for use in treatment trials for adults with developmental disabilities. The results from this project are of considerable public health significance in that they will establish a measure of functional outcome for adults with developmental disabilities that is broadly applicable across different conditions and severity spectra, and that can be used to monitor treatment changes in clinical trials seeking to improve functioning in adults with autism spectrum disorder and other developmental disabilities.","8625861; 7543041 (contact); ","EACK, SHAUN M; MAZEFSKY, CARLA A (contact);","KAU, ALICE S","05/19/2020","02/28/2025","Adaptive Behaviors; Adult; Age; autism spectrum disorder; base; biological sex; Calibration; Caregivers; Categories; Child; Childhood; Clinical; Clinical Trials; cognitive interview; Communities; Comprehension; design; Development; Developmental Disabilities; Diagnosis; Dimensions; disability; Down Syndrome; emotion dysregulation; Employment; Ensure; Equipment and supply inventories; Evaluation; Evidence based treatment; experience; Factor Analysis; Family; Fragile X Syndrome; functional disability; functional outcomes; Group Homes; improved; improved functioning; Independent Living; Individual; Information Systems; Inpatients; Intellectual functioning disability; Intervention; Intervention Studies; Knowledge; Life; Loneliness; Measurement; Measures; Methodology; Methods; Modeling; Monitor; Mood Disorders; Neurodevelopmental Disorder; neuropsychiatry; novel; Occupations; Outcome; Outcome Measure; Outpatients; Parents; Participant; Patient Outcomes Assessments; Patient Self-Report; Patients; Population; Property; Proxy; Psychometrics; Public Health; Reporter; Reporting; Research; response; Sampling; service providers; Severities; skills; social; social deficits; Social Functioning; Social isolation; Societies; sound; success; Symptoms; Testing; theories; therapy development; Time; treatment effect; treatment trial; Underserved Population; United States National Institutes of Health; Validity and Reliability; ","Change-sensitive Measurement of Adult Functional Outcomes in Developmental Disabilities","100392","ZRG1","Special Emphasis Panel ","","","01","426598","241028","667626",""
"9992133","F32","AA","1","N","05/19/2020","05/19/2020","","273","F32AA028416","SCHOOLS OF MEDICINE","PA-19-188","1F32AA028416-01","NIAAA:64554\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM","","RICHMOND","UNITED STATES","PHARMACOLOGY","04","105300446","US","353201","VIRGINIA COMMONWEALTH UNIVERSITY","VA","232980568","Project Narrative Alcohol alters internal states, leading to changes in learning and memory mechanisms. Because of this, alcohol and other substances can cause a phenomenon known as state dependent learning, when the execution of a learned behavior is more effective when it is performed in the same internal state it was acquired. Here I use the model organism Caenorhabditis elegans as a means to identify the molecular mechanism and neurocircuitry of state dependent learning.","15170128; ","LINDSAY, JONATHAN HOUGHTON;","LORANG-LEINS, DOMINIQUE","09/30/2020","","Ablation; addiction; Affect; Alcohol dependence; alcohol effect; alcohol exposure; alcohol misuse; Alcohol or Other Drugs use; Alcoholic Intoxication; alcoholism therapy; Alcohols; Alleles; Animal Model; Animals; arm; Behavior; Behavioral; Behavioral Assay; behavioral response; Binding; Caenorhabditis elegans; Caffeine; Cells; Chromosome Mapping; Code; Conflict (Psychology); Coupled; Coupling; Data; Dependence; Dopamine; drug of abuse; Ethanol; Exhibits; Exposure to; Felis catus; forward genetics; gamma-Aminobutyric Acid; Genes; Genetic; genetic approach; Genetic Models; Genetic Screening; genetic variant; genome sequencing; Genomics; Glutamates; Goals; human subject; Impairment; learned behavior; Learning; Left; Link; long term memory; Mammals; Maps; Mediating; Memory; memory process; memory recall; Modeling; Molecular; Moods; mutant; Mutation; Names; Nervous system structure; Neurobiology; neuronal circuitry; Neurons; neurotransmission; Neurotransmitters; Nicotine; nicotine exposure; novel; Octopamine; Odors; Olfactory Learning; Olfactory Pathways; olfactory stimulus; Organism; Pain; Peptide Signal Sequences; Positioning Attribute; Prevention; Process; Receptor Protein-Tyrosine Kinases; Sensory; Signal Transduction; sobriety; societal costs; Stimulus; Study models; Testing; whole genome; Work; X Chromosome; ","Worms learning while intoxicated: determining the molecular mechanism and neuronal circuitry required for state dependent learning in Caenorhabditis elegans","028416","ZAA1","Special Emphasis Panel ","","","01","64554","","64554",""
"9889930","R01","CA","5","N","05/18/2020","04/01/2020","03/31/2021","394","R01CA207893","SCHOOLS OF MEDICINE","PA-16-160","5R01CA207893-04","NCI:435435\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","NEW YORK","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","12","121911077","US","5998304","NEW YORK UNIVERSITY SCHOOL OF MEDICINE","NY","10016","We will study how tamoxifen resistance in ER+ breast cancer by EGFR/ER? pathways involves selective mRNA translation mediated by hyperactivation of the protein kinases mTORC1 and ERK/MNK1, through the selective translation of specific mRNAs and eIF4E availability and phosphorylation.","1865292; ","SCHNEIDER, ROBERT ;","KONDAPAKA, SUDHIR B","04/01/2017","03/31/2022","Adjuvant Therapy; Animals; Aromatase Inhibitors; Biopsy Specimen; Breast Cancer Cell; Breast Cancer cell line; Breast cancer metastasis; Cell Line; Cell Survival; Cessation of life; Disease; EGFR Protein Overexpression; EIF4EBP1 gene; Endocrine; Epidermal Growth Factor Receptor; Estrogen Receptor alpha; Estrogen receptor positive; Estrogen Receptors; Estrogen Therapy; FRAP1 gene; Genetic Translation; hormone therapy; Indolent; inhibitor/antagonist; malignant breast neoplasm; MAP Kinase Gene; Mediating; Mediator of activation protein; Messenger RNA; Modeling; mortality; neoplastic cell; novel; Pathway interactions; Peptide Initiation Factors; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Play; Postmenopause; pre-clinical research; Premenopause; Protein Kinase; Recurrence; Relapse; Resistance; response biomarker; Ribosomes; Role; Signal Transduction; small molecule; Tamoxifen; Testing; therapeutic target; Toxic effect; Translations; tumor; tumor growth; Tumorigenicity; Woman; ","the mTOR translational control pathway in tamoxifen resistant ER+ breast cancer","207893","CAMP","Cancer Molecular Pathobiology Study Section ","","","04","256894","178541","435435",""
"10148413","U24","CA","3","N","05/19/2020","04/01/2020","08/31/2020","394","U24CA196175","","RFA-CA-14-501","3U24CA196175-05S1","NCI:812707\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","COLUMBUS","UNITED STATES","","03","147212963","US","1495302","RESEARCH INST NATIONWIDE CHILDREN'S HOSP","OH","432052664","PUBLIC HEALTH RELEVANCE: Cancer research is dependent on the availability of high quality biospecimens linked to patient information from clinical trials. The SWOG Biospecimen Bank collects, processes, banks and distributes biospecimens from adult cancer patients enrolled on NCI-sponsored clinical trials. These biospecimens are eventually used by researchers studying different types of cancer. The results of the research benefits patients by, among other things, contributing to the development of new cancer treatments and to the improvement of patient care.","8769686; 7704642 (contact); ","RAE, JAMES MICHAEL; RAMIREZ MILAN, NILSA DEL CARMEN (contact);","MAKHLOUF, HALA","04/23/2015","08/31/2020","Address; Adult; anticancer research; base; biobank; Breast; cancer clinical trial; Cancer Patient; cancer therapy; cancer type; Clinical; Clinical Data; Clinical Medicine; Clinical Research; Clinical Treatment; Clinical trial protocol document; Clinical Trials; Clinical Trials Information for Patients; Collection; Colon; Component of the National Cancer Institute; Data; design; Development; Diagnostic; Disease; Enrollment; Ensure; Epidemiology; follow-up; Guidelines; Health; Human; Infrastructure; innovative technologies; Laboratories; laboratory equipment; leukemia; Link; Lung; Lymphoma; Malignant Neoplasms; melanoma; Molecular Biology; Molecular Profiling; Multiple Myeloma; National Cancer Institute; National Clinical Trials Network; Operative Surgical Procedures; Pathologic; Patient Care; Patients; Pediatric Hospitals; Procedures; Process; programs; Prostate; Protocols documentation; public health relevance; Reporting; Research; Research Personnel; Residual state; Resources; Sampling; Services; Southwest Oncology Group; Specimen; Therapeutic; translational medicine; Translational Research; Treatment Protocols; treatment trial; tumor; Tumor Bank; Work; ","SWOG Biospecimen Bank","196175","ZCA1","Special Emphasis Panel ","","S1","05","664368","148339","812707",""
"9980923","R01","GM","5","N","05/21/2020","05/01/2020","04/30/2021","859","R01GM102687","SCHOOLS OF ARTS AND SCIENCES","PA-18-484","5R01GM102687-07","NIGMS:209434\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","PASADENA","UNITED STATES","NONE","27","009584210","US","1073501","CALIFORNIA INSTITUTE OF TECHNOLOGY","CA","911250001","Project narrative This application is relevant to the NIH mission as it addresses questions related to the biological function of metals. Our goals are to test mechanistic hypotheses related to the function of Photosystem II from plants by investigating model metal-oxo clusters and to determine the chemical principles underlying the biological production of dioxygen, a molecule required for human life. The described electron, proton and oxygen-atom transfer studies are relevant to many such processes occurring at metal sites in proteins of living organisms, including humans.","10750487; ","AGAPIE, THEODOR ;","ANDERSON, VERNON","09/01/2013","04/30/2023","Active Sites; Address; Affect; Atmosphere; Behavior; Benchmarking; Binding; Biochemical; Biochemical Reaction; Biological; Biological Models; Biological Process; biological systems; Catalysis; chemical property; Chemicals; Complement; Complex; Cyanobacterium; Dioxygen; Electron Spin Resonance Spectroscopy; electronic structure; Electrons; experimental study; Generations; Goals; Hand; Human; interest; Investigation; Isotope Labeling; Life; Ligands; manganese oxide; metal complex; metal oxide; Metals; Methods; Mission; Modeling; Nature; Organism; oxidation; Oxidation-Reduction; Oxygen; Photosynthesis; photosystem II; physical property; Physiologic pulse; Planet Earth; Plants; Process; Production; Property; protein complex; Proteins; protonation; Protons; Role; Route; Site; small molecule; spectroscopic survey; Spectrum Analysis; Structural Models; Structure; System; Techniques; Testing; Theoretical Studies; United States National Institutes of Health; Water; Work; X ray spectroscopy; ","Synthetic Models of the Oxygen Evolving Complex of Photosystem II","102687","MSFA","Macromolecular Structure and Function A Study Section ","","","07","140000","69434","209434",""
"9985114","K23","HD","5","N","05/18/2020","05/01/2020","04/30/2021","865","K23HD096056","SCHOOLS OF MEDICINE","PA-18-375","5K23HD096056-02","NICHD:163165\","OTHER RESEARCH-RELATED","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","BALTIMORE","UNITED STATES","FAMILY MEDICINE","07","188435911","US","820104","UNIVERSITY OF MARYLAND BALTIMORE","MD","212011508","Public Health Relevance Statement: The empowerment of women and families to prevent unintended pregnancy and to plan births is a critical public health goal. A contraceptive shared decision-making tool for providers who work with vulnerable populations such as poor, immigrant Latinas has the potential to decrease rates of unintended pregnancy and associated health disparities. This study advances NICHD?s mission that every person is born healthy and wanted and that women suffer no harmful effects related to reproduction.","9723923; ","CARVAJAL, DIANA N;","KING, ROSALIND B","07/29/2019","04/30/2024","Address; Adherence; adverse outcome; Award; Baltimore; base; Birth; care providers; career development; Caring; Client satisfaction; Clinical; Clinical Research; Coercion; Color; Communication; Communities; contextual factors; Contraceptive Agents; Contraceptive methods; Contraceptive Usage; Counseling; Decision Making; design; Development; Development Plans; discounting; Effectiveness; empowerment; ethnic discrimination; Ethnic group; Evaluation; experience; Family; Family Planning; Family Practice; Feeling; Goals; group counseling; health care availability; health disparity; health goals; Health Personnel; Health Services Accessibility; Immigrant; Immigration; improved; instrument; Interview; Involuntary Sterilization; Knowledge; Language; Latina; Latino; Low income; male; Maryland; Measurement; Measures; medical schools; Mentors; Mentorship; Methods; Minority; Mission; Modeling; National Institute of Child Health and Human Development; negative affect; novel; Outcome; Outcome Measure; patient oriented; Patient Preferences; patient-clinician communication; Patient-Focused Outcomes; Patients; Perception; Persons; Phase; Planned Pregnancy; Platelet Factor 4; point of care; Population; preference; pregnancy prevention; pressure; prevent; Process; professor; Property; Provider; Psychometrics; Public Health; public health relevance; Qualitative Methods; Qualitative Research; racial and ethnic; Recording of previous events; Reporting; Reproduction; Reproductive Health; Research; Research Methodology; Research Personnel; Research Technics; shared decision making; skills; Specific qualifier value; support tools; Techniques; Testing; theories; therapy development; Time; tool; Training; Trust; unintended pregnancy; Universities; usability; Visit; Vulnerable Populations; Woman; Work; ","Development and Testing of a Point-of-Care Shared Decision-Making Tool for Providers","096056","CHHD","National Institute of Child Health and Human Development Initial Review Group ","","","02","151079","12086","163165",""
"9950746","K08","HL","1","N","05/18/2020","05/18/2020","04/30/2021","837","K08HL151747","SCHOOLS OF MEDICINE","PA-19-117","1K08HL151747-01","NHLBI:115007\","OTHER RESEARCH-RELATED","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CORAL GABLES","UNITED STATES","SURGERY","27","052780918","US","5221250","UNIVERSITY OF MIAMI SCHOOL OF MEDICINE","FL","331462926","PROJECT NARRATIVE Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory condition that affects 10% of the United States adult population, and with serious cardiac and ischemic complications for half of these patients. Anti-hyperlipidemic therapies do not fully address the burden of ASCVD in the population. The research and training proposed in this application are relevant to public health because they increase our understanding of the cellular mechanisms associated with atherosclerosis development, progression, and potential resolution.","14589496; ","MARTINEZ, LAISEL ;","HUANG, LI-SHIN","05/18/2020","04/30/2025","Acute; acute coronary syndrome; Address; Adhesions; Adult; Affect; Agonist; Animals; Apoptotic; Arterial Fatty Streak; atherogenesis; atheroprotective; Atherosclerosis; base; Biology; Blood Vessels; Bone Marrow Transplantation; Cardiac; career development; Cells; Cholesterol; Chronic; Clinical; cytokine; Cytometry; Data; design; Development; Development Plans; Disease; Disease Progression; Doctor of Pharmacy; Ensure; Environment; Equipment; Extravasation; Fellowship; Foam Cells; Fostering; Funding; Genetic; Goals; Human Resources; IL-13Ralpha1; Immunology; in vivo; Infiltration; Inflammation; Inflammatory; Integrins; interest; Interleukin-13; interleukin-13 receptor; Interleukin-4; Investigation; Ischemic Stroke; ITGAM gene; ITGB2 gene; Journals; Knock-in; Laboratories; Leadership; Lesion; Leukocytes; lipid metabolism; Lipids; loss of function; macrophage; Macrophage-1 Antigen; Manuscripts; Mediating; medical schools; Mentors; Mentorship; Microsurgery; Modeling; monocyte; morphometry; multidisciplinary; Mus; Myofibroblast; Necrosis; novel; novel therapeutic intervention; Operative Surgical Procedures; Outcome; Patients; Peptide Hydrolases; Peripheral; Phagocytosis; Pharmacists; Pharmacology; Pharmacotherapy; Phenotype; Population; post-doctoral training; professor; Public Health; Publications; Publishing; Reactive Oxygen Species; receptor; recruit; Research; Research Assistant; Research Personnel; Research Support; Research Training; Resolution; Resource Sharing; Resources; Respiratory Burst; Rest; Role; Scientist; Signal Transduction; Site; skills; Smooth Muscle Myocytes; Specificity; Speed; Stable Disease; Surgical Models; Testing; Time; tool; Training; Training Programs; tumor; United States; Universities; uptake; Vascular Diseases; vascular inflammation; Work; ","Cellular Mechanisms of Mac-1 Mediated Atheroprotection","151747","ZHL1","Special Emphasis Panel ","","","01","106488","8519","115007",""
"9976453","T32","AR","5","N","05/22/2020","05/01/2020","04/30/2021","846","T32AR053461","SCHOOLS OF MEDICINE","PA-14-015","5T32AR053461-15","NIAMS:268438\","TRAINING, INSTITUTIONAL","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","PHILADELPHIA","UNITED STATES","PHYSIOLOGY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","PUBLIC HEALTH RELEVANCE: The muscle community at the University of Pennsylvania has established an outstanding training program in Muscle Biology and Muscle Disease, supported in part by the T32 mechanism. Members of the Penn community are known world-wide for excellence in muscle research, and this program facilitates collaborative training opportunities for predoctoral students and postdoctoral fellows. Our training program enables trainees to work in laboratories directed by principal investigators who are leaders in the study of the cell biolog, genetics, physiology, and/or pathology of muscle.","1868703; ","OSTAP, E. MICHAEL;","BOYCE, AMANDA T","05/01/2006","04/30/2021","Biology; Muscle; Myopathy; Training; ","Training in Muscle Biology and Muscle Disease","053461","AMS","Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee ","","","15","286486","20767","268438",""
"9885833","R01","DK","1","N","05/19/2020","05/19/2020","04/30/2021","847","R01DK117124","SCHOOLS OF MEDICINE","PA-19-056","1R01DK117124-01A1","NIDDK:416915\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","PHILADELPHIA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","PROJECT NARRATIVE The goal of this project is to understand how physical signaling mechanisms are used to control tissue architecture in digestive organs. Characterization of these signaling mechanisms will help us better understand normal digestive function, how digestive organs repair themselves following injury, and how digestive tumors progress.","1936401; ","PACK, MICHAEL A;","GREENWEL, PATRICIA","05/19/2020","04/30/2023","Animal Model; Animals; Architecture; Biological; Birth; cancer cell; cell behavior; Cell membrane; cell motility; Cells; clinically relevant; Colorectal; design; Digestive System Disorders; Disease; Engineering; Enteric Nervous System; Epithelial; Epithelial Cells; Epithelium; Esophageal Atresia; Esophagus; Esophagus motility; experimental study; Familial colorectal cancer; Family; Gastrointestinal Motility; Gastrointestinal Neoplasms; Gastrointestinal tract structure; Genes; Germ-Line Mutation; Goals; Heritability; Heterozygote; Homozygote; Human; In Vitro; in vivo; Injury; intestinal epithelium; Intestines; Knock-in; Laboratories; Lesion; Life; Link; Malignant Neoplasms; Mammalian Cell; Mediating; Membrane; Modeling; motility disorder; mouse model; Mus; Muscle Contraction; mutant; Mutation; MYH11 gene; Myosin ATPase; Myosin Heavy Chains; nervous system development; novel; Oncogenic; Organ; Oxidation-Reduction; Pathologic; Pathway interactions; Phenotype; Physiology; Play; Process; Proteins; pup; Regulation; repaired; response; Risk Factors; Role; Signal Pathway; Signal Transduction; Small Intestines; Smooth Muscle; Smooth Muscle Myosins; Stomach; Stress; stressor; Syndrome; tissue regeneration; Tissues; Translations; tumor progression; Variant; WNT Signaling Pathway; Work; Zebrafish; ","Physical Signaling Mechanisms That Regulate Intestinal Architecture","117124","ZRG1","Special Emphasis Panel ","","A1","01","257355","159560","416915",""
"9930126","U01","HL","5","N","05/22/2020","05/01/2020","04/30/2021","838","U01HL130045","SCHOOLS OF MEDICINE","PAR-13-128","5U01HL130045-05","NHLBI:3878301\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","TUCSON","UNITED STATES","PEDIATRICS","03","806345617","US","490201","UNIVERSITY OF ARIZONA","AZ","857210158","PUBLIC HEALTH RELEVANCE: Childhood asthma is a major public health challenge, affecting 7.1 million children in the US alone. We will give a safe powder made up of detoxified pathogenic bacteria (Bronchovaxom) for two years to infants and young children at high risk for asthma, and determine if the proportion of children treated with this product who develop persistent wheezing during the third year off medicine is lower than that of children treated with placebo. If successful, our trial will provide the first proven therapy that can prevent asthma tha begins in early life.","1882730; ","MARTINEZ, FERNANDO D;","NOEL, PATRICIA","05/04/2016","04/30/2021","Affect; Age; Age-Months; aged; airway remodeling; Allergens; Allergic; Animals; arm; Asthma; asthma exacerbation; asthma prevention; base; Birth; burden of illness; Cells; Child; Childhood Asthma; Clinical Trials; cohort; Development; disability; Disease; disorder prevention; Double-Blind Method; Emergency Situation; epidemiology study; ethnic minority population; Europe; Freeze Drying; high risk; high risk infant; Hypersensitivity; Immune; infancy; Infant; inner city; Intervention; Lead; Life; Lung; Mediating; Medicine; Nursery Schools; Oral; Participant; Pathogenesis; pathogenic bacteria; Pharmaceutical Preparations; Pharmacologic Substance; pharmacovigilance; Placebos; Powder dose form; Predisposition; prevent; Prevention; primary outcome; Primary Prevention; Process; Public Health; public health relevance; Quality of life; Randomized; Recurrence; Research; respiratory; Respiratory physiology; response; Rhinovirus; Safety; secondary outcome; Symptoms; Testing; Time; underserved rural area; Virus Diseases; Wheezing; ","ORBEX: Primary Prevention of Asthma and Wheezing in Children-CCC Lead Application","130045","CLTR","Clinical Trials Review Committee ","","","05","3543989","334312","3878301",""
"10150157","U19","AI","3","N","05/18/2020","04/15/2020","11/30/2020","","U19AI089992","","PA-18-591","3U19AI089992-09S3","NIAID:695543\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW HAVEN","UNITED STATES","","03","043207562","US","9420201","YALE UNIVERSITY","CT","065208327","","1866468; ","SHAW, ALBERT C;","DONG, GANG","05/18/2020","11/30/2021","","Core D:  Clinical Recruitment","089992","","","7294","S3","09","428548","266995","","695543"
"9906235","P01","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P01GM095467","","PAR-13-280","5P01GM095467-10","NIGMS:379151\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","","1887763; ","SERHAN, CHARLES NICHOLAS;","","","","Acute; Address; Animal Diseases; Animal Model; Anti-inflammatory; Antibiotic Resistance; Apoptotic; Area; Aspirin; Biological; Candidate Disease Gene; CD59 Antigen; Chemicals; Coin; Consensus; Coupled; Dermal; Disease; Dose; Eicosanoids; Exudate; Family; Genes; Goals; Human; human tissue; Immune response; Immunosuppression; improved; in vivo; indexing; Individual; Infection; Infection Control; Inflammation; Inflammatory Response; innovation; Lead; Leukocytes; Life; lipid mediator; Lung; macrophage; Maps; Mediator of activation protein; member; Microbe; microbial; Mission; Molecular; mouse model; Mus; Natural regeneration; neutrophil; Neutrophil Infiltration; novel; Operative Surgical Procedures; Organic Synthesis; Pathway interactions; Patient Care; Peritonitis; Pharmacology; Phase; Physiological; Process; programs; Resolution; response; response to injury; Role; Sepsis; Series; Signal Pathway; Signal Transduction; Stimulus; Structure; Surgical Injuries; System; Testing; tissue regeneration; Tissues; tool; Trauma; Validation; ","Project 1: Novel Specialized Pro-Resolving Lipid Mediators (SPM) in Resolution of Acute Inflammation","095467","ZGM1","Special Emphasis Panel ","6581","","10","238613","140538","","379151"
"9939696","R37","MH","5","N","05/18/2020","05/01/2020","04/30/2021","242","R37MH057881","SCHOOLS OF MEDICINE","PA-11-260","5R37MH057881-23","NIMH:551590\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PITTSBURGH","UNITED STATES","PSYCHIATRY","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","","2091734; ","DEVLIN, BERNIE ;","GITIK, MIRI","07/01/1998","04/30/2023","Affect; Award; Behavior; Brain region; cell type; Communities; Data; Development; Disease; Disease model; Doctor of Philosophy; dynamic system; Etiology; experience; Foundations; Funding; Gene Expression; Genetic; genetic association; Genetic Risk; genetic variant; Genetic Variation; Genomics; Goals; Human Genetics; improved; Individual; insight; Lead; mental disorder prevention; Mental disorders; Methods; Mind; Modeling; Names; neural circuit; neurobiological mechanism; Neurobiology; novel; Positioning Attribute; Prevention; Research Personnel; Risk; risk variant; Role; Schizophrenia; Signal Transduction; Statistical Methods; theories; transcriptome; transcriptomics; Variant; Work; ","Genetics Association in Schizophrenia and Other Disorders","057881","NSS","Special Emphasis Panel ","","","23","452677","98913","551590",""
"10144521","P01","AI","3","N","05/18/2020","05/18/2020","08/31/2020","855","P01AI089473","","PA-18-591","3P01AI089473-06S1","NIAID:134318\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","DETROIT","UNITED STATES","","13","073134603","US","218602","HENRY FORD HEALTH SYSTEM","MI","482023450","Project Narrative We will conduct a study to enroll and observe eligible children and their family members that are current participants in our NIH-funded studies in order to report the presence and occurrence of infection with the SARS-CoV-2 virus (COVID-19) in children and household contacts.","1968885 (contact); 1885785; ","JOHNSON, CHRISTINE C  (contact); OWNBY, DENNIS R;","MINNICOZZI, MICHAEL","05/18/2020","08/31/2021","2019-nCoV; access restrictions; Adult; Affect; Antibodies; Asthma; Biological; Birth; Caregivers; Cellular Phone; Child; Childhood; Clinical Research; cohort; Cohort Studies; Communicable Diseases; Communities; COVID-19; design; Development; Eczema; Emergency Situation; Enrollment; epidemiologic data; Epidemiology; Exposure to; Extrinsic asthma; Family; Family member; Feces; Funding; health care availability; Home environment; Household; Human; Incidence; indexing; individualized prevention; Infection; Lung diseases; microbiota; Nose; Participant; peripheral blood; Procedures; prospective; Protocols documentation; recruit; Reporting; Research; response; sample collection; Sampling; Siblings; Site; Source; surveillance study; Surveys; Swab; Symptoms; Telephone; Time; United States National Institutes of Health; viral detection; virology; Virus; Visit; ","Human Epidemiology and Response to SARS-CoV-2 (HEROS)","089473","","","","S1","06","89248","45070","134318",""
"10043688","R21","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R21AI154254","SCHOOLS OF ARTS AND SCIENCES","PA-19-053","1R21AI154254-01","NIAID:204933\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","RENO","UNITED STATES","BIOLOGY","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","NARRATIVE  This project follows up the discovery, made in the NIAID drug screening program, of a new lead compound, TL020, for treatment of chronic hepatitis B. TL020 belongs to a class of small molecules that decrease expression of specific cell-surface proteins by a new mechanism: binding the protein's signal peptide during biosynthesis and blocking its transport across the endoplasmic reticulum membrane. The proposed studies will determine the specific protein targeted by TL020, optimize the structure, potency, and drug-like properties of this lead, and identify drug candidates for preclinical drug development studies in vivo.","1895530; ","BELL, THOMAS W.;","DAVIS, MINDY I","05/21/2020","04/30/2022","Address; Affinity; Alzheimer's Disease; Amino Acids; Anabolism; analog; anti-hepatitis B; Anti-HIV Agents; Antigens; Antiviral Agents; aqueous; Atherosclerosis; autism spectrum disorder; Binding; Binding Proteins; Biological Assay; Cell surface; Cell Surface Proteins; Cells; Chronic Hepatitis B; Collaborations; cytotoxicity; design; Development; Disease; DNA; DNA-Directed DNA Polymerase; Dose; drug candidate; drug development; Drug Kinetics; Drug Screening; Endoplasmic Reticulum; Evaluation; Exploratory/Developmental Grant; Frontotemporal Lobar Degenerations; Genetic Transcription; Goals; Graves' Disease; Hepatitis B; Hepatitis B Virus; high reward; high risk; Human; Immune; In Vitro; in vivo; in vivo evaluation; inhibitor/antagonist; interest; Lead; lead optimization; lipophilicity; malignant breast neoplasm; Measures; Membrane; Metabolic; Methods; Microsomes; Modeling; Molecular Target; Mus; National Institute of Allergy and Infectious Disease; novel; novel therapeutics; Peptide Signal Sequences; Permeability; Pharmaceutical Preparations; Pharmacotherapy; physical property; pre-clinical; Preclinical Drug Development; preclinical evaluation; Production; Program Development; Property; protein expression; Proteins; Rewards; Risk; screening; screening program; small molecule; Solubility; sortilin; Structure; Structure-Activity Relationship; Surface; Testing; therapeutic protein; Thyrotropin Receptor; Toxic effect; Translations; Viral Genome; Virion; water solubility; ","Development of a Novel Inhibitor for Hepatitis B","154254","SBCA","Synthetic and Biological Chemistry A Study Section ","","","01","150000","54933","204933",""
"9930451","P01","GM","5","N","05/20/2020","05/01/2020","04/30/2021","859","P01GM099134","SCHOOLS OF MEDICINE","PAR-13-280","5P01GM099134-09","NIGMS:1829040\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","LOS ANGELES","UNITED STATES","BIOCHEMISTRY","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","Overall Project Narrative The information generated by the combined effort of the Plath, Zaret, and Hochedlinger labs' program will provide valuable insights into the efficient, timely and faithful reprogramming of somatic cells into pluripotent stem cells. Successful completion of our specific aims will greatly facilitate the generation of reprogrammed cells and autologous derivatives for transplantation and disease modeling. Our synergistic efforts will also provide important knowledge about other forms of cellular reprogramming and further our understanding of basic mechanisms that control cell fate transitions.","8752436; ","PLATH, KATHRIN ;","GIBBS, KENNETH D","08/01/2011","04/30/2022","Address; Area; Autologous; Biological; Cell Differentiation process; Cell Fate Control; cell type; Cells; Chromatin; cohesion; Collaborations; data sharing; Development; direct application; Disease; Disease model; Enhancers; Ensure; epigenomics; flexibility; Funding; Generations; Genetic; Genetic Transcription; Genomics; Goals; Grant; Heterochromatin; High-Throughput Nucleotide Sequencing; human model; insight; Institution; Knowledge; Laboratories; mouse model; Natural regeneration; novel; Pattern; Pilot Projects; pluripotency; Pluripotent Stem Cells; Polyadenylation; Polyadenylation Pathway; Post-Transcriptional Regulation; Program Research Project Grants; programs; Proteins; Publishing; Regulator Genes; Research Personnel; Services; Somatic Cell; Stem cells; synergism; Technology; Time; Transcription Process; transplant model; ","Reprogramming Genetic Networks to a Pluripotent State","099134","ZRG1","Special Emphasis Panel ","","","09","1569015","260025","1829040",""
"10028145","R01","AI","1","N","05/20/2020","05/20/2020","04/30/2021","855","R01AI153195","SCHOOLS OF MEDICINE","PA-19-056","1R01AI153195-01","NIAID:668513\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","RIVERSIDE","UNITED STATES","NONE","41","627797426","US","577506","UNIVERSITY OF CALIFORNIA RIVERSIDE","CA","925210001","The optimal host response to mucosal infection relies on the critical balance between pathogen killing (immunity) and limiting immunopathology (tolerance) in the host. Host disease tolerance is especially important in infections with macroparasites such as helminths that cause significant tissue damage, therefore investigating these host disease tolerance mechanisms may be applicable to the treatment of tissue injury and inflammation of significant public health impact. This proposal will investigate how the secreted protein RELMa contributes to host disease tolerance to helminths through regulation of alternatively activated macrophage subsets, macrophage-helminth interactions and macrophage-lung stromal cell interactions.","10212934; ","NAIR, MEERA GOH;","PESCE, JOHN T","05/20/2020","04/30/2025","3-Dimensional; Acute; Address; Adoptive Cell Transfers; Adoptive Transfer; Air; airway epithelium; base; Biological Assay; Biology; Blocking Antibodies; Bone Marrow; CD4 Positive T Lymphocytes; Cell Communication; Cells; Cellular Structures; Chimera organism; Chimeric Proteins; Coculture Techniques; Complement; cytokine; Data; design; Disease; eosinophil; Epithelial Cells; Equilibrium; experimental study; Gene Expression; genetic signature; healing; helminth infection; Helminths; Hematopoietic; Heterogeneity; Hookworm Infections; Hookworms; Human; Immune; Immune response; Immunity; immunopathology; Impairment; Infection; Inflammation; Inflammatory; inhibitor/antagonist; Injury; insight; Integrins; Knockout Mice; Liquid substance; Lung; Lung Inflammation; lung repair; macrophage; Measures; Mediating; Mesenchymal Stem Cells; migration; Migration Assay; monocyte; mouse model; Mucous Membrane; Mus; new therapeutic target; Nippostrongylus; novel; Parasites; pathogen; pathogenic microbe; Pathogenicity; Pathologic; Pathology; Pathway interactions; Proteins; Public Health; public health relevance; Reagent; Recovery; Regulation; Reporter; resistin; Resolution; response; Rodent; scaffold; Signal Pathway; Signal Transduction; Soil; Stromal Cells; Structure of parenchyma of lung; System; Technology; Therapeutic; tissue injury; tissue repair; Tissues; Wound Healing; ","RELMalpha-expressing macrophages mediate host disease tolerance in mucosal infection","153195","IHD","Immunity and Host Defense ","","","01","444342","224171","668513",""
"9930447","T32","HD","5","N","05/22/2020","05/01/2020","04/30/2021","865","T32HD040127","SCHOOLS OF MEDICINE","PA-16-152","5T32HD040127-19","NICHD:457086\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","CHAPEL HILL","UNITED STATES","PSYCHIATRY","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","Narrative Individuals with neurodevelopmental disorders, such as autism, intellectual disability, and fetal alcohol syndrome often have severe impairments that require lifelong care, resulting in a substantial burden to affected individuals, their families, and their communities. The complexity of these conditions demands an integrated strategy that cuts across traditional research boundaries between the behavioral and basic biological sciences, including the boundaries between animal and human studies, as well as the boundaries between the laboratory and real-world applications. In this postdoctoral research training program in neurodevelopmental disorders, we propose an integrated diverse training program that will prepare researchers to interface across disciplines and to make transformative advances for the betterment of individuals with neurodevelopmental disorders.","1872095; 1867321 (contact); ","PHILPOT, BENJAMIN D; PIVEN, JOSEPH  (contact);","KAU, ALICE S","05/15/2001","04/30/2022","Neurodevelopmental Disorder; Research; ","Postdoctoral Research in Neurodevelopmental Disorders","040127","ZHD1","Special Emphasis Panel ","","","19","423228","33858","457086",""
"9999100","D71","TW","1","N","05/18/2020","05/19/2020","12/31/2020","989","D71TW011530","","PAR-19-284","1D71TW011530-01","FIC:30240\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","KAMPALA","UGANDA","","","850536636","UG","793001","MAKERERE UNIVERSITY","","7062","PROJECT NARRATIVE Non-communicable diseases (NCD) and ageing represent a growing burden of morbidity among people living with HIV/AIDS and countries such as Uganda have limited capacity to address the burgeoning dual epidemic. Research training in LIC provides an avenue to build capacity for locally generated investigations aimed at integrated prevention and management of HIV/AIDS, NCD and ageing. Building on existing infrastructure and international collaborations at Makerere University College of Sciences (MakCHS), we propose a planning application for a comprehensive multi-specialty research-training program for HIV, NCD and ageing at MakCHS in Uganda.","11014111; 2245825; 10484958 (contact); ","CASTELNUOVO, BARBARA ; CHECKLEY, WILLIAM N; KIRENGA, BRUCE JAMES (contact);","BANSAL, GEETHA PARTHASARATHY","05/19/2020","12/31/2021","Africa South of the Sahara; Aging; AIDS/HIV problem; antiretroviral therapy; Applications Grants; base; Collaborations; college; Communicable Diseases; Data; Epidemic; Epidemiology; Goals; Grant; Health; health related quality of life; health science research; Health Sciences; HIV; HIV/TB; improved; Institution; Knowledge; Longevity; low and middle-income countries; Malaria; medical specialties; Morbidity - disease rate; mortality; Pathogenesis; Population; Process; recruit; Research; Research Personnel; Research Training; scale up; Secondary to; Site; Surveys; Training Programs; Uganda; Universities; ","Makerere University College of Health Sciences - research training at the intersection of HIV/AIDS, Non-Communicable Diseases and Ageing.","011530","ZRG1","Special Emphasis Panel ","","","01","28000","2240","30240",""
"9919612","R01","HL","5","N","05/18/2020","05/01/2020","04/30/2021","838","R01HL111084","SCHOOLS OF MEDICINE","PA-18-484","5R01HL111084-07","NHLBI:378750\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","ALBUQUERQUE","UNITED STATES","ANATOMY/CELL BIOLOGY","01","829868723","US","10021612","UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR","NM","871310001","PROJECT NARRATIVE The experiments in this proposal will examine the cellular mechanism involved in the development of pulmonary hypertension, a progressive and life-threatening disease with limited treatment options. In particular, we will determine the role of acid-sensing ion channel 1 (ASIC1) in mediating metabolic changes that leads to enhanced proliferation within the pulmonary vasculature during development of pulmonary hypertension. Such information is crucial to advancing treatment and developing new therapeutic options to treat this devastating disease.","7829102; ","JERNIGAN, NIKKI L;","XIAO, LEI","02/01/2013","04/30/2023","Acidosis; aerobic glycolysis; Animals; Apoptosis; Apoptotic; ASIC channel; Bioenergetics; Blood Vessels; Cell Death; Cell membrane; cell type; Cells; Cessation of life; Chronic; Complex; Data; Degenerative Disorder; Deoxyglucose; Development; Disease; Event; experimental study; extracellular; Future; Genetic; genetic approach; glucose uptake; Glycolysis; Glycolysis Inhibition; glycosylation; Heart failure; Hypoxia; Inner mitochondrial membrane; Ion Pumps; Life; Lung; Malignant Neoplasms; Mediating; Membrane; Membrane Potentials; Membrane Proteins; Metabolic; Metabolic dysfunction; Metabolism; Mitochondria; mitochondrial dysfunction; mitochondrial membrane; mitochondrial metabolism; Molecular; Morphology; Muscle; Muscle function; Muscular Atrophy; novel therapeutic intervention; novel therapeutics; Outcome; Oxidative Phosphorylation; Pathogenicity; Pharmacology; Phenotype; Play; Pulmonary Hypertension; Pulmonary Vascular Resistance; Regulation; Resistance; Respiration; Right Ventricular Hypertrophy; Role; Signal Transduction; Smooth Muscle Myocytes; Stimulus; Structure; Testing; Therapeutic; trafficking; Up-Regulation; Vascular Proliferation; Vascular remodeling; Vascular resistance; Vascular Smooth Muscle; vasoconstriction; Warburg Effect; ","Vascular Smooth Muscle Function in Pulmonary Hypertension","111084","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","","07","250000","128750","378750",""
"9890186","R01","ES","1","N","05/21/2020","05/21/2020","03/31/2021","113","R01ES031391","SCHOOLS OF PUBLIC HEALTH","RFA-AI-18-054","1R01ES031391-01","NIEHS:173691\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","PROVIDENCE","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","01","001785542","US","1003201","BROWN UNIVERSITY","RI","029129002","PROJECT NARRATIVE Environmental degradation and exposure to heavy metals (over which individuals often have little control) may have a direct impact on cardiovascular diseases (CVD) development. The ongoing Brazilian Longitudinal Study of Adult Health (in Portuguese, ?Estudo Longitudinal de Sau´ de do Adulto?, ELSA-Brasil), the only large prospective study established in South America, represents a unique resource to study the roles of multiple metal exposures and their interactions with dietary trace elements in affecting CVD risk. Specifically, we aim to determine if antagonistic effects of metals exist and if trace elements could reduce toxic metal impact on CVD outcomes in men and women participated in ELSA_Brasil with the hope that this work would lead to simple, safe, readily available, and highly-affordable nutritional intervention for CVD prevention that will have both clinical and public health significance worldwide.","1874898 (contact); 15889050; ","LIU, SIMIN  (contact); LOTUFO, PAULO ANDRADE;","JOUBERT, BONNIE","05/21/2020","03/31/2024","adjudicate; Adult; Affect; Arsenic; Biological Process; Biology; Biomedical Research; Blood; Blood Preservation; Brazil; Cadmium; cardiometabolism; Cardiovascular Diseases; cardiovascular disorder prevention; cardiovascular disorder risk; Cardiovascular system; case control; Case-Control Studies; Cessation of life; China; Chromium; Clinical; Cobalt; cohort; Collection; Consensus; Copper; coronary artery calcium; coronary calcium scoring; cost efficient; Cross-Sectional Studies; Data; data resource; design; Developing Countries; Development; Diabetes Mellitus; diabetes risk; Diet; Dietary Intervention; dietary trace element; disability; Disease; Disease Outcome; Environmental Exposure; Epidemic; Etiology; Europe; Event; experience; Exposure to; follow-up; Funding Opportunities; global health; Health; Heavy Metals; Hypertension; Individual; interest; International; Interview; Investments; Joints; Laboratories; Lead; Link; Longitudinal Studies; Magnesium; Manganese; Mediating; men; Mercury; Metabolism; Metal exposure; Metals; Molybdenum; Myocardial Ischemia; National Toxicology Program; nervous system disorder; Nested Case-Control Study; Nickel; Obesity; Outcome; Participant; Persons; Physical Examination; physical inactivity; Play; Population; population based; population health; Portuguese; Positioning Attribute; programs; Prospective cohort; Prospective cohort study; Prospective Studies; Public Health; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Selenium; Serum; Site; Smoking; South America; Stroke; Supplementation; Testing; Time; Toxic effect; toxic metal; Trace Elements; Trace metal; Tungsten; United States; Urine; Vanadium; Vascular Diseases; Vascular System; Woman; Work; Zinc; ","Environmental heavy metals and risk of ischemic heart disease and stroke in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)","031391","ZRG1","Special Emphasis Panel ","","","01","106887","66804","173691",""
"9918854","R01","AI","5","N","05/18/2020","05/21/2020","04/30/2021","855","R01AI130066","","PA-16-160","5R01AI130066-04","NIAID:743157\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","OAKLAND","UNITED STATES","","13","150829349","US","3497005","KAISER FOUNDATION RESEARCH INSTITUTE","CA","946123466","PROJECT NARRATIVE On January 1, 2018, California will enact a Senate Bill (SB27), making it the first state in the U.S. to ban non- therapeutic antimicrobial use in livestock production. This measure, designed to curb overuse of antibiotics in industrial food animal production represents a singular opportunity for a natural experiment to rigorously evalu- ate the role of industrial livestock production on antimicrobial resistance in E. coli from meat-source and human infection. We will leverage whole genome sequencing and expansive electronic health record data to deter- mine whether an upstream, statewide policy to reduce antibiotic use in livestock production will have a down- stream, beneficial impact on human health.","8960291; ","TARTOF, SARA ;","ERNST, NANCY L","05/09/2017","04/30/2022","Address; Affect; Air; American; Animal Feed; Antibiotics; antimicrobial; antimicrobial drug; Antimicrobial Resistance; Antimicrobial susceptibility; base; biobank; California; Cephalosporins; Chickens; Clinical; Clinical Data; cost; Data; Decision Making; density; design; disorder prevention; DNA Polymerase I; Domestic Fowls; Electronic Health Record; Elements; Epidemiologic Methods; Escherichia coli; Evaluation; evidence base; Experimental Designs; Exposure to; Food; foodborne; Future; Generations; Genes; genome sequencing; Gentamicins; Growth; gut colonization; Health; Health system; Human; Incidence; Industrialization; Infection; infection risk; Ingestion; innovation; Intervention; Laboratories; Lead; Link; Livestock; Location; man; Measures; Meat; Meat Products; Methods; Milk; Mobile Genetic Elements; Molecular; Multi-Drug Resistance; Natural experiment; operation; Outpatients; pathogen; pathogenic Escherichia coli; Pathway interactions; Patients; Pattern; Phenotype; Phylogenetic Analysis; Policies; Population; population health; Prevalence; Prevention; Production; Resistance; resistance gene; Resistance profile; Resistance to infection; Risk; Risk Factors; Role; Sales; Soil; Source; spatial relationship; spatiotemporal; Specimen; Statistical Data Interpretation; Statutes and Laws; System; Tail; Testing; Tetracyclines; Therapeutic; Time; TimeLine; transmission process; trend; Urinary tract infection; Veterinarians; Water; whole genome; Work; ","Antimicrobial resistant E. coli before and after California Senate bill 27 (ARES):  a natural experiment","130066","CRFS","Clinical Research and Field Studies of Infectious Diseases Study Section ","","","04","594548","148609","743157",""
"9964683","U54","CA","5","N","05/18/2020","05/01/2020","04/30/2021","","U54CA209988","","RFA-CA-15-014","5U54CA209988-04","NCI:388272\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","11327023; ","HEISER, LAURA MADELINE;","","","","Aftercare; Biological Assay; Biological Markers; Breast Cancer Cell; Breast Cancer cell line; Breast Cancer Patient; cancer cell; Cell Communication; Cell Line; Cells; Clinical; combinatorial; cytokine; design; Development; Dimensions; Disease; DNA Sequence Alteration; Drug Combinations; Drug resistance; Drug usage; Drug-sensitive; epigenomics; Evolution; experimental study; Expression Profiling; Extracellular Matrix Proteins; Gene Expression Profiling; Genetic Transcription; Goals; Growth Factor; Heterogeneity; Image; imaging study; Immunofluorescence Immunologic; improved; improved outcome; inhibitor/antagonist; Lead; malignant breast neoplasm; Malignant Neoplasms; Measures; Mediating; Microarray Analysis; Modeling; Molecular; Molecular Profiling; neoplastic cell; new technology; novel; novel drug combination; novel strategies; novel therapeutics; Outcome; Pathway interactions; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Phenotype; Principal Component Analysis; Property; Proteins; Reagent; Residual Cancers; Resistance; response; Role; Sampling; Signal Transduction; single-cell RNA sequencing; Stimulus; Systems Biology; targeted treatment; Testing; Therapeutic; therapeutic candidate; Therapeutic Intervention; therapeutic target; Therapeutic Uses; therapy resistant; Time; transcriptome sequencing; Treatment Protocols; treatment response; treatment strategy; triple-negative invasive breast carcinoma; tumor; tumor heterogeneity; tumor microenvironment; Work; Xenograft procedure; ","Managing Microenvironment-mediated Heterogeneity and Resistance","209988","ZCA1","Special Emphasis Panel ","8359","","04","252125","136147","","388272"
"10136403","R21","AI","7","N","05/20/2020","04/01/2020","03/31/2021","855","R21AI144529","BIOMED ENGR/COL ENGR/ENGR STA","PA-18-590","7R21AI144529-02","NIAID:294591\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","Chicago","UNITED STATES","BIOMEDICAL ENGINEERING","09","160079455","US","6144601","NORTHWESTERN UNIVERSITY","IL","606114579","PROJECT NARRATIVE Chagas disease is an infection that affects millions of people in the western hemisphere from Canada to Argentina, damaging the heart, colon and esophagus, and imposing an economic burden on the world greater than cholera or cervical cancer. The current drugs for treating Chagas are moderately effective but suffer from tremendous toxicity that often require the physician to stop treatment. Our research focuses on nanotechnology, the formulation of tiny particles containing drugs, to develop a better formulation that is more effective than the current drugs AND greatly reduces toxicity in hopes of helping the millions of people with this serious infection.","7898171; ","SCOTT, EVAN A;","O'NEIL, MICHAEL T","03/06/2019","03/31/2021","Acute; acute infection; Affect; Argentina; Benznidazole; Biodistribution; Bite; Blood Transfusion; Canada; carcinogenicity; Cardiac Myocytes; Cardiomyopathies; cell type; Cells; Chagas Disease; Cholera; Chronic; chronic infection; Colon; Complex; Consumption; Data; Development; Diagnostic; dosage; Drug Delivery Systems; Drug Formulations; Drug usage; Economic Burden; Epidemic; Esophagus; ethylene glycol; experience; Flow Cytometry; Food Contamination; Formulation; Goals; heart damage; Immigrant; Immune; Immunotherapeutic agent; improved; in vivo; Individual; Infection; Injectable; Injections; innovation; interest; intraperitoneal; Intravenous; Latin American; Los Angeles; macrophage; Malignant neoplasm of cervix uteri; Maternal-Fetal Transmission; Micelles; mouse model; mTOR Inhibitor; Myocarditis; nanocarrier; nanomaterials; Nanotechnology; nanotherapy; neurotoxicity; Nifurtimox; novel; Organ; Organ Transplantation; Parasitemia; Parasites; particle; Pathology; Peritoneal; Phagocytes; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Physicians; Population; prophylactic; propylene; Research; Role; side effect; Sirolimus; stem; Sulfides; System; theranostics; Therapeutic; Therapeutic Agents; Therapeutic Effect; Tissues; Toxic effect; Trypanosoma cruzi; United States; uptake; vector; Work; ","Development and characterization of a nanocarrier for enhanced delivery of benznidazole during acute and chronic T. cruzi infection","144529","ZRG1","Special Emphasis Panel ","","","02","186450","108141","294591",""
"9996782","K23","MD","5","N","05/18/2020","05/01/2020","04/30/2021","307","K23MD014164","","PA-18-374","5K23MD014164-03","NIMHD:167629\","OTHER RESEARCH-RELATED","2020","National Institute on Minority Health and Health Disparities","","NEW YORK","UNITED STATES","","13","079683257","US","10041176","GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY","NY","100274516","PROJECT NARRATIVE African American (AA) women are overwhelmingly physically inactive and suffer disproportionately from associated health conditions, including type II diabetes, coronary heart disease, and obesity. Smartphone applications technology provides a substantial opportunity to deliver evidenced-based behavioral interventions tailored for AA women and help to promote adherence to physical activity.","14180907; ","SILLICE, MARIE ALINE;","TABOR, DERRICK C","08/15/2019","04/30/2024","actigraphy; Address; Adherence; Adult; African American; Age; Awareness; base; Behavior; behavior change; Behavior Therapy; Behavioral; Cardiovascular Diseases; career; Caregivers; Cellular Phone; Characteristics; Child; Chronic; Chronic Disease; Coronary heart disease; Counseling; Cultural Diversity; Data; Development; Diabetes Mellitus; Disease; Disease Management; efficacy trial; Enhancement Technology; Environment; Environmental Risk Factor; Evaluation; evidence base; exercise intervention; Expectancy; experience; Feedback; fitbit; Focus Groups; follow-up; Foundations; Goals; Head; Health; Household; improved; Individual; innovation; Instruction; Internet; Intervention; intervention effect; Intervention Studies; Interview; K-Series Research Career Programs; Leadership; Measures; meetings; Mentored Patient-Oriented Research Career Development Award; Metadata; Minority; minority health; moderate-to-vigorous physical activity; Monitor; Motivation; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Patient Self-Report; Pattern; peer; Physical activity; physical inactivity; Population; post intervention; Prevalence; Prevention; Prevention Research; primary outcome; programs; Protocols documentation; prototype; Randomized; Recommendation; Reporting; Research; Research Methodology; Research Personnel; Research Training; Risk; Role; satisfaction; sedentary lifestyle; Self Efficacy; skills; smartphone Application; Social Network; social norm; Social support; Structure; Suggestion; Technology; Telephone; Text; Text Messaging; theories; Theory of Change; Time; Training; Translating; Triad Acrylic Resin; usability; Woman; ","Developing a Tailored, Theoretically-Driven Smartphone Physical Activity Intervention for African American Women","014164","ZMD1","Special Emphasis Panel ","","","03","155212","12417","167629",""
"9921433","P30","EY","5","N","05/20/2020","04/01/2020","03/31/2021","","P30EY008098","","PAR-17-322","5P30EY008098-32","NEI:135623\","RESEARCH CENTERS","2020","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","","1883362; ","FUNDERBURGH, JAMES L;","","","","Cell Culture Techniques; Consult; Consultations; Core Grant; experience; Experimental Designs; flexibility; Goals; Histological Techniques; Histology; investigator training; light microscopy; Maintenance; Preparation; protocol development; Research Personnel; Sampling; Services; Techniques; tissue culture; tissue preparation; Training; Training Activity; Virus; Vision; Vision research; ","Tissue Culture and Histology Core","008098","ZEY1","Special Emphasis Panel ","5950","","32","93176","42447","","135623"
"9937163","P01","AG","2","N","05/22/2020","04/01/2020","03/31/2021","","P01AG002132","","PAR-18-297","2P01AG002132-39","NIA:605314\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","2415454; ","PRUSINER, STANLEY B;","","","","7 year old; Age; Age of Onset; aged; Aging; Alleles; alpha synuclein; Alzheimer's Disease; Alzheimer's disease risk; Amyloid beta-Protein; Animal Model; Apolipoprotein E; apolipoprotein E-4; Area; Astrocytes; Autopsy; Biological; Biological Assay; Blood; Blood Tests; Brain; care costs; Caring; case control; Cell Line; Cell model; cell type; Cells; Cerebral Amyloid Angiopathy; Child; cognitive control; cohort; Collaborations; Collection; comorbidity; Complement; Controlled Study; Cryoelectron Microscopy; Data; Deposition; Disease; disease diagnosis; Disease Progression; Dissection; Down Syndrome; Event; exosome; experimental study; Freezing; Funding; Gap Junctions; Gender; Genes; Genetic; genetic risk factor; Genetic study; genome sequencing; Genotype; Glial Fibrillary Acidic Protein; Gliosis; Human; human tissue; Impaired cognition; in vivo; Individual; Inherited; Investigation; Kinetics; Knock-in; Late Onset Alzheimer Disease; Length; Longevity; Luciferases; Measures; Medical; Methods; Modeling; Molecular; Molecular Genetics; molecular modeling; Molecular Profiling; Monitor; Mosaicism; Mus; mutant; Mutation; Nerve Degeneration; Neurodegenerative Disorders; Neurofibrillary Tangles; Neurons; neuropathology; non-demented; novel; Pathogenesis; Pathology; Patients; Phenotype; Prion Diseases; prion-based; Prions; Protein Isoforms; Proteins; Proteomics; Protocols documentation; PrP; Publishing; racial diversity; relating to nervous system; Reporter; Research; Rodent; Rodent Model; Role; Sampling; solid state nuclear magnetic resonance; Specimen; Structure; Surveys; synthetic peptide; System; tau mutation; tau Proteins; Tauopathies; Testing; Therapeutic; Time; tool; Transgenes; Transgenic Mice; Transgenic Organisms; Treatment Efficacy; whole genome; Work; ","Project 1: Pathobiology and Genetics of Prions Causing Alzheimer's Disease","002132","ZAG1","Special Emphasis Panel ","6194","","39","375000","230314","","605314"
"9889186","R01","NS","5","N","05/20/2020","05/01/2020","04/30/2021","853","R01NS102279","BIOMED ENGR/COL ENGR/ENGR STA","PA-16-160","5R01NS102279-04","NIA:518545\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","PASADENA","UNITED STATES","ENGINEERING (ALL TYPES)","27","009584210","US","1073501","CALIFORNIA INSTITUTE OF TECHNOLOGY","CA","911250001","The proposal is relevant to public health because mutations in the macromolecule known as p97 ATPase, an enzyme that takes part in recycling and disposal of proteins, cause degenerative diseases. These mutants result in build-up of toxic proteins and are considered promising targets for new drugs. We have obtained new information on how the mutants work, and will use this data to test new small molecules that inhibitor p97 mutants, which may lead to new drugs to treat frontotemporal dementia, myopathy, and ALS symptoms.","9779880; ","CHOU, TSUI-FEN ;","GUBITZ, AMELIE","07/01/2018","04/30/2023","Affect; Affinity; age related; Alleles; ALS patients; Amino Acids; Amyotrophic Lateral Sclerosis; Animal Model; Apoptosis; Area; ATP phosphohydrolase; Autophagocytosis; base; Binding; Biochemical; Bioinformatics; Biological Assay; Biological Process; Brain; caveolin 1; Cell Death; Cells; Clinical; cofactor; Data; Defect; Degenerative Disorder; design; Development; Disease; Disease Marker; disease phenotype; Emery-Dreifuss Muscular Dystrophy; Enzymes; Excision; Exhibits; experience; experimental study; Fibroblasts; Frontotemporal Dementia; Genetic; Genotype; Goals; Golgi Apparatus; Hela Cells; Heterogeneous-Nuclear Ribonucleoproteins; Human; Impairment; improved; Inclusion Bodies; Inclusion Body Myopathy with Early-Onset Paget Disease; induced pluripotent stem cell; Inherited; inhibitor/antagonist; Integral Membrane Protein; knock-down; Knock-in Mouse; Knock-out; Lead; Leadership; LoxP-flanked allele; macromolecule; Measures; Mediating; Methodology; Missense Mutation; Mitotic; Modeling; Molecular; Molecular Conformation; Motor Neuron Disease; Motor Neurons; mouse model; multicatalytic endopeptidase complex; Muscle Cells; mutant; Mutate; Mutation; Myopathy; nervous system disorder; Neurodegenerative Disorders; Neurons; new therapeutic target; novel therapeutics; Osteitis Deformans; overexpression; p97 ATPase; Pathogenicity; Pathology; Pathway interactions; Patients; Penetrance; Phenotype; Precision therapeutics; prevent; Protein Family; protein misfolding; protein TDP-43; Proteins; Proteomics; Public Health; Publishing; Quality Control; Recycling; Regulation; Reporter; skills; small molecule inhibitor; Source; Stem cells; Symptoms; System; targeted treatment; Testing; Therapeutic Intervention; Ubiquitin; Work; ","Dysregulation of p97/VCP disease mutants in IBM and FTLD-U","102279","CMND","Cellular and Molecular Biology of Neurodegeneration Study Section ","","","04","368460","150085","518545",""
"10019062","U01","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","U01AI152881","SCHOOLS OF MEDICINE","RFA-AI-19-042","1U01AI152881-01","NIAID:1258779\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW YORK","UNITED STATES","SURGERY","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","Project Narrative Xenotransplantation of composite islet-kidneys (I-K) containing autologous islets, has the capacity to cure both renal failure and diabetes for patients suffering from end-stage diabetic nephropathy, which is currently an unmet medical need. If successful, our approach could provide a virtually limitless donor supply of islets and kidneys, a methodology that avoids the need for long-term immunosuppression and donor kidneys from miniature swine, which attain sizes similar to those of human recipients.","2432435; 6407921 (contact); ","SACHS, DAVID H; YAMADA, KAZUHIKO  (contact);","NABAVI, NASRIN N","05/21/2020","04/30/2025","Allogenic; Animal Model; Animals; Antibodies; Antigens; Autoimmune Process; Autologous; Blood Vessels; Bone Marrow; Bone Marrow Transplantation; capsule; Chimerism; Chronic; Clinical; clinical application; Clinical Treatment; clinically relevant; Data; Diabetes Mellitus; diabetic; Diabetic Nephropathy; Disease; Donor person; experimental study; Family suidae; Goals; Human; Hybrids; Immune response; Immunosuppression; improved; Inbreeding; innovation; Insulin-Dependent Diabetes Mellitus; islet; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Kidney Failure; Kidney Transplantation; kidney xenograft; Laboratories; Living Donors; Medical; Methodology; Methods; Miniature Swine; Modeling; Molecular; Morbidity - disease rate; mortality; Nature; new technology; nonhuman primate; Organ; Pancreas; Pancreas Transplantation; Pancreatectomy; Papio; Patients; Population; pre-clinical; Prevalence; Protocols documentation; Regimen; Renal Glycosuria; response; Risk; Techniques; Technology; Testing; Therapeutic immunosuppression; Thymic epithelial cell; Thymus Gland; Time; Tissues; Toxic effect; Transgenic Organisms; Transplantation; Vascularization; virtual; Xenograft procedure; ","Composite porcine islet-kidney xenotransplants to cure diabetes and renal failure","152881","ZAI1","Special Emphasis Panel ","","","01","777024","481755","1258779",""
"9921223","U54","MD","5","N","05/18/2020","04/01/2020","03/31/2021","","U54MD010722","","RFA-MD-15-013","5U54MD010722-05","NIMHD:370326\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1985665; ","HAAS, DAVID W;","","","","Active Learning; Address; African American; American; Anti-HIV Agents; Antidepressive Agents; Behavioral; biobank; Biological; clinical practice; Clinical Research; cohort; Cohort Studies; Collaborations; Communities; cross disciplinary program; CYP2B6 gene; Data; Data Analyses; depressive symptoms; Development; Development Plans; diabetic; Differential Diagnosis; Discipline; DNA; education resources; Educational Curriculum; efavirenz; emotional distress; Ethnic Origin; European; Fostering; Frequencies; Future; Genetic; Genomic medicine; Genomics; Genotype; Goals; health disparity; Health Professional; help-seeking behavior; Hispanics; human genomics; Infrastructure; innovation; Institutes; Institution; investigator training; Knowledge; large datasets; learning community; learning strategy; Legal; Link; member; Mentors; Needs Assessment; Patient Self-Report; peer coaching; peer learning; Phenotype; Policies; population health; Precision Health; precision medicine; programs; Publications; Race; Research; Research Methodology; Research Personnel; Resources; Self-Direction; Series; Services; social; Social Behavior; Specimen; Suicide; Symptoms; System; Time; Training; training opportunity; Translating; Translational Research; Work; working group; ","Training and Mentoring Core","010722","ZMD1","Special Emphasis Panel ","8202","","05","287126","83200","","370326"
"9930458","P01","GM","5","N","05/20/2020","05/01/2020","04/30/2021","","P01GM099134","","PAR-13-280","5P01GM099134-09","NIGMS:514488\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","8752436; ","PLATH, KATHRIN ;","","","","Bioinformatics; Budgets; cohesion; Collaborations; Core Facility; data management; data sharing; Doctor of Philosophy; Ensure; Epigenetic Process; Evaluation Research; Feedback; Financial Support; Genetic; Genomics; Grant; High-Throughput Nucleotide Sequencing; Infrastructure; Institution; Investigation; Lead; Leadership; Link; National Institute of General Medical Sciences; new technology; novel strategies; Pilot Projects; pluripotency; Policies; Productivity; programs; recruit; Regulation; Reporting; Research Personnel; Resources; stem cell biology; Stem Cell Research; Stem cells; Structure; synergism; ","Administrative Core for P01 - Reprogramming Genetic Networks to a Pluripotent State","099134","ZRG1","Special Emphasis Panel ","6047","","09","403047","111441","","514488"
"10029328","R01","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R01AI153275","SCHOOLS OF MEDICINE","PA-19-056","1R01AI153275-01","NIAID:385262\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOUISVILLE","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","03","057588857","US","4679701","UNIVERSITY OF LOUISVILLE","KY","402920001","Alphaviruses, such as Sindbis virus, Chikungunya virus, and Venezuelan Equine Encephalitis virus are significant threats to public health. Alphaviral infection in otherwise healthy individuals may result in severe disease- including persistent severe multi-joint arthritis, viral encephalitis, and death. This proposal seeks to characterize the importance of a novel noncapped viral RNA in regards to the establishment of viral infection and pathogenesis, for the purpose of improving the understanding of alphaviral biology to identify innovative therapeutic strategies.","10849785; ","SOKOLOSKI, KEVIN JOSEPH;","DUPUY, LESLEY CONRAD","05/21/2020","04/30/2025","Address; Affect; Alphavirus; Alphavirus Infections; Antiviral Agents; Antiviral Therapy; Arthritis; Attenuated; base; Binding; Biology; Brain; Cell Line; Cessation of life; Chikungunya virus; Clinical; combinatorial; Defect; defined contribution; Development; Disease; Disease Outbreaks; effective therapy; Environment; Event; exhaustion; expectation; Failure; Gene Expression; genomic RNA; Genomics; Growth; Histologic; Immune response; Impairment; improved; In Vitro; in vivo; Individual; Infection; Innate Immune Response; innovation; Integration Host Factors; Interferons; Internal Ribosome Entry Site; Invertebrates; Joints; Kinetics; knowledge base; Link; Modeling; Molecular; Molecular Analysis; Morbidity - disease rate; mortality; mutant; Nature; negative affect; neuroinflammation; novel; Nucleocapsid; particle; pathogen; Pathogenesis; Pathologic; Process; Production; Proteins; Proteomics; Public Health; Reporting; Research; response; RNA; RNA chemical synthesis; Role; Ross river virus; Sindbis Virus; Structure; Techniques; Testing; Therapeutic; tissue culture; tissue/cell culture; transcriptomics; Vaccines; vector-borne pathogen; Venezuelan Equine Encephalitis Virus; Viral; Viral Encephalitis; Viral Genes; Viral Pathogenesis; viral RNA; Virion; Virulence; Virus Diseases; Virus Replication; Wild Type Mouse; Work; ","Comprehensive Definition of the Critical Role(s) of the Alphaviral Noncapped Genomic RNAs to Infection and Pathogenesis","153275","VIRA","Virology - A Study Section ","","","01","250000","135262","385262",""
"10141434","K00","CA","4","N","05/19/2020","05/01/2020","04/30/2021","393","K00CA245473","","RFA-CA-19-002","4K00CA245473-02","NCI:90720\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","BOSTON","UNITED STATES","","07","076580745","US","1464901","DANA-FARBER CANCER INST","MA","022155450","Project Narrative Inhibition of the Nrf2-Keap1 pathway has become an attractive target for lung cancer treatment, since mutations in Nrf2, which are associated with chemoresistance and poor survival, have been found in lung cancer patients. However, there are no specific and potent Nrf2 inhibitors currently available, and the few compounds that have been reported as Nrf2 inhibitors have only been tested for treatment of tumors in xenograft models, which lack an intact immune system. In addition to identifying and developing a novel Nrf2 inhibitor, my research proposal tests the important question of whether Nrf2 inhibitors will be effective for treating tumors in immune-competent mice, which must be addressed before we consider inhibiting the Nrf2 pathway for treating lung cancer.","15849233; ","ZHANG, DI ;","ELJANNE, MARIAM","05/01/2020","04/30/2024","Address; anticancer research; base; Biological Assay; Bone Marrow Transplantation; cancer cell; Cancer Etiology; Cancer Model; Cancer Patient; cancer prevention; cancer therapy; carcinogenesis; Carcinogenicity Tests; Carcinogens; Carcinoma; career; cell type; Cells; Cessation of life; chemotherapy; Clinical; Combined Modality Therapy; Data; Defense Mechanisms; Development; Effectiveness; Environment; Epithelial Cells; experience; Exposure to; Flow Cytometry; gain of function mutation; high throughput screening; Homeostasis; Immune; immune activation; Immune system; Immunophenotyping; immunoregulation; Immunosuppressive Agents; Immunotherapy; Impairment; improved; improved outcome; In Vitro; in vitro activity; in vivo; inhibitor/antagonist; Institution; interest; Knockout Mice; Lead; Libraries; loss of function mutation; Lung; Lung Neoplasms; malignant breast neoplasm; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Malignant Neoplasms; Metabolic; Modeling; mouse model; Mus; Mutation; neoplastic cell; Nitrogen; novel; novel therapeutic intervention; Outcome; Oxidative Stress; Oxygen; Pathway interactions; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Phase; Positioning Attribute; Postdoctoral Fellow; Pre-Clinical Model; pre-doctoral; preclinical study; Predisposition; prevent; Process; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; response; Role; Scientist; Signal Pathway; Signal Transduction; skills; small molecule; Specificity; success; Survival Rate; Techniques; Testing; Therapeutic; therapy outcome; Training; transcriptome sequencing; tumor; tumor microenvironment; tumorigenesis; Validation; Vinyl Carbamate; Wild Type Mouse; Xenobiotics; Xenograft Model; ","Targeting the Nrf2 pathway in cancer","245473","ZCA1","Special Emphasis Panel ","","","02","84000","6720","90720",""
"9910408","R01","EY","5","N","05/20/2020","05/01/2020","04/30/2021","867","R01EY028153","SCHOOLS OF MEDICINE","PA-16-160","5R01EY028153-03","NEI:400000\","Non-SBIR/STTR RPGs","2020","NATIONAL EYE INSTITUTE","","NEW YORK","UNITED STATES","OPHTHALMOLOGY","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","PROJECT NARRATIVE  Although glaucoma is a leading cause of blindness, current treatment strategies are not sufficient to prevent progressive injury to specific nerve cells, and patients with glaucoma continue to lose their visual function. This proposed project specifically aims to determine the disease-causing importance of a specific inflammatory molecule (called NF-?B) by modeling glaucoma in specific mouse strains lacking the activity of this molecule in glia (that are adjacent to nerve cells and play diverse roles in supporting or damaging the nerve cells), so that we will be able to determine whether supression of this molecule controls inflammation and protects nerve cells from inflammatory injury in mouse glaucoma. We expect that the new information will help develop new treatment possibilities for millions of Americans suffering from this blinding disease.","6803489; ","TEZEL, GULGUN ;","MCKIE, GEORGE ANN","05/01/2018","04/30/2022","adaptive immune response; American; Animal Model; anterior chamber; Astrocytes; Attention; Autoantibodies; Autopsy; Axon; base; Blindness; cell type; chemokine; Clinical; Comparative Study; Complement; cytokine; Data; design; Disease; Drug Targeting; Ensure; event cycle; experimental study; Genetic Transcription; Glaucoma; glial activation; Homeostasis; Human; Image; Immune; immunogenic; immunoregulation; Individual; Inflammation; Inflammation Mediators; Inflammatory; inflammatory milieu; Inflammatory Response; Injections; Injury; Mass Spectrum Analysis; Methodology; Methods; Microglia; Microspheres; Modeling; Molecular; Molecular Analysis; Mouse Strains; Mus; Nerve Degeneration; Neuroglia; neuroinflammation; Neuronal Injury; Neurons; neuroprotection; neurotoxic; neurotoxicity; Ocular Hypertension; Optic Disk; Optic Nerve; Outcome; Outcome Study; Pathway interactions; Patients; Pharmaceutical Preparations; Phenotype; Pilot Projects; Play; prevent; Process; Production; Regulation; response; Retina; Retinal; Role; Sampling; Site; Structure; T-Lymphocyte; Testing; Time; Transcription Coactivator; Transgenic Mice; Transgenic Organisms; treatment strategy; viscoelasticity; Vision; Work; ","Regulation of Glia-driven Neuroinflammation in Glaucoma","028153","DPVS","Diseases and Pathophysiology of the Visual System Study Section ","","","03","250000","150000","400000",""
"9922227","P01","AG","5","N","05/22/2020","05/01/2020","04/30/2021","","P01AG031719","","PAR-13-258","5P01AG031719-10","NIA:349431\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","DURHAM","UNITED STATES","","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","The male-female health-survival paradox (in which women live longer but men appear healthier) is pervasive in contemporary Western societies, but little is known about whether it exists in other human societies or in animals. Investigating wild primates for evidence of the paradox, we have found that females live longer and appear healthier, while males deteriorate more rapidly than females in key aspects of their social environment. To better understand how the social environment enhances health and survival, we will examine social relationships, patterns of recovery from illness, and hormones in a primate that, like humans, exhibits greater longevity with better social environments.","1918559; ","ALBERTS, SUSAN C.;","","","","Age; age related; Aging; Algorithms; Animals; Biological Markers; Collaborations; comparative; Comparative Study; crosslink; Data; Data Set; Demography; Deterioration; disability; Economics; Event; Evolution; Exhibits; experience; Female; Glucocorticoids; Goals; healing; Health; health difference; Hormonal; Hormones; Human; human male; Individual; Injury; injury recovery; insight; Kenya; Knowledge; Lead; Left; Life; Light; Link; Literature; Longevity; male; Marmota; Measurement; Measures; Mediating; Mediation; Medical; men; Methodology; Methods; Modeling; Modernization; mortality; nonhuman primate; novel; Onset of illness; Papio; Pattern; Physiological; Population; Primates; Program Research Project Grants; prospective; Records; Recovery; Resources; response; Risk Factors; sex; Sex Differences; social; Social Environment; social factors; Social isolation; social relationships; Social status; social stress; Societies; Source; Stress; System; Techniques; Testing; Time; Traction; Woman; Women's Health; Work; Wound Healing; ","Project 3","031719","ZAG1","Special Emphasis Panel ","8038","","10","246691","102740","","349431"
"9922976","R01","HD","5","N","05/21/2020","05/01/2020","04/30/2021","865","R01HD098176","","PA-18-480","5R01HD098176-02","NICHD:478568\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","COLUMBUS","UNITED STATES","","03","147212963","US","1495302","RESEARCH INST NATIONWIDE CHILDREN'S HOSP","OH","432052664","PROJECT NARRATIVE Teen drivers who have committed a traffic violation are at increased risk for crashes, injuries, and deaths. Through partnership with the local Juvenile Traffic Court, this randomized controlled trial will assess the effectiveness of an innovative in-vehicle driving feedback technology, with and without parent training, on reducing risky driving events, unsafe driving behaviors, and recidivism among high-risk teen drivers, which correlates with NICHD?s mission to prioritize research on teen driver safety.","8608266; ","YANG, JINGZHEN ;","MAHOLMES, VALERIE","05/01/2019","04/30/2024","Acceleration; Adolescent; Age; Appearance; Automobile Driving; base; Behavior; Cause of Death; Cessation of life; Communication; Control Groups; County; court; Devices; distracted driving; driving behavior; driving safety; effective intervention; Effectiveness; Enrollment; Event; Evidence based program; Fatality rate; Feedback; Frequencies; Goals; group intervention; Hearing; high risk; high risk population; improved; improved outcome; Injury; innovation; Intervention; intervention effect; Legal Guardians; Licensing; Measures; Mission; National Institute of Child Health and Human Development; novel; Ohio; Outcome; Outcome Study; Parents; Phase; Policies; prevent; programs; Randomized; Randomized Controlled Trials; recidivism; recruit; Research; Risk; Safety; smartphone Application; Specialist; Speed; Summary Reports; Supervision; System; Technology; teen driving; Teenagers; Testing; therapy design; Time; Training; United States; universal prevention; unsafe driving; Vehicle crash; virtual; ","Intervention to Improve Driving Practices Among High-Risk Teen Drivers","098176","CLHP","Community-Level Health Promotion Study Section ","","","02","368519","110049","478568",""
"10037851","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI153485","SCHOOLS OF MEDICINE","PA-19-053","1R21AI153485-01","NIAID:211875\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW YORK","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","12","060217502","US","1514803","WEILL MEDICAL COLL OF CORNELL UNIV","NY","100654805","Project Narrative Malaria is a huge global health problem with 250 million cases per year and more than 400,000 deaths annually. Our goal is to develop small chemical molecules that force malaria parasites to produce its own poisons. Successful completion of the proposed studies will provide proof of concept and prototypes to develop such molecules as anti-malarial therapeutics.","10356821; ","LIN, GANG ;","O'NEIL, MICHAEL T","05/22/2020","04/30/2022","Active Sites; Africa; African; analog; Antimalarials; Artemisia annua; Artemisinins; base; Binding; Biological Models; Caseins; Cells; Cessation of life; Chemicals; Child; Clinical; Combined Modality Therapy; design; Development; Drug Combinations; Drug Interactions; Drug resistance; Enzyme Inhibition; Erythrocytes; Evolution; global health; Goals; Hemin; HIV; Human; Hybrids; improved; in vitro Model; inhibitor/antagonist; Lactones; Life Cycle Stages; Malaria; Malignant Neoplasms; Medication Management; multicatalytic endopeptidase complex; Mutation; Oligopeptides; Organism; oxidative damage; Parasites; Patient Noncompliance; Penetration; Peptides; Pharmaceutical Preparations; pharmacophore; Phenotype; Plasmodium falciparum; Point Mutation; Poison; prevent; Prevention; Prodrugs; Proteasome Inhibitor; Proteins; Proteome; prototype; Reporting; residence; Resistance; Resistance development; Sesquiterpenes; Site; Southeastern Asia; standard care; Substrate Specificity; success; System; Testing; Therapeutic; Time; Tissues; tuberculosis treatment; Ubiquitin; Ursidae Family; Vertebral column; Zidovudine; ","Compounds that force Plasmodium falciparum to produce its own inhibitors","153485","ZRG1","Special Emphasis Panel ","","","01","125000","86875","211875",""
"9921219","U54","MD","5","N","05/18/2020","04/01/2020","03/31/2021","","U54MD010722","","RFA-MD-15-013","5U54MD010722-05","NIMHD:544586\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","7182203; ","WILKINS, CONSUELO HOPKINS;","","","","Address; Affect; African American; Collaborations; collaborative environment; Communication; Communities; community involvement; Consultations; Data; Development; Discipline; Doctor of Philosophy; Elements; Ensure; Environment; experience; General Population; Genetic; genome sciences; Goals; health disparity; health equity; Health Personnel; Human; Immunologist; Incentives; informatics tool; Infrastructure; innovation; Institutes; Institution; Language; Latino; Leadership; medical schools; Medicine; meetings; member; Methods; Molecular; novel; Outcome; Perception; population health; Precision Health; precision medicine; Problem Solving; programs; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rewards; Schools; Science; skills; Strategic Planning; tool; translational scientist; Universities; user-friendly; virtual; Vision; ","Administrative Core","010722","ZMD1","Special Emphasis Panel ","8199","","05","422235","122351","","544586"
"9952115","F32","HL","5","N","05/22/2020","05/15/2020","05/14/2021","838","F32HL147437","","PA-18-670","5F32HL147437-02","NHLBI:68987\","TRAINING, INDIVIDUAL","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","Project Narrative Current therapies for serious influenza viral infections that target viral proteins and are not fully effective in preventing influenza-associated deaths. Our studies will provide novel insights into the mechanisms by which a host protein (Mmp-8) increases the severity of IAV infections in mice. In addition, we will test the therapeutic efficacy of a nanobody that selectively inhibits Mmp-8 in reducing IAV-induced mortality and lung disease in mice.","15021215; ","WANG, XIAOYUN ;","KALANTARI, ROYA","05/15/2019","05/14/2022","Active Sites; adaptive immune response; adverse outcome; airway epithelium; Animals; Antiviral Agents; B-Lymphocytes; Body Weight decreased; care burden; CD4 Positive T Lymphocytes; Cell Count; Cessation of life; Cleaved cell; Data; Diagnosis; effective therapy; Epithelial; Epithelial Cells; Epithelium; Fellowship; Future; Goals; Healthcare; Histocompatibility Antigens Class II; human subject; Immune response; improved; improved outcome; Individual; Inflammation Mediators; Inflammatory Response; Influenza; Influenza A virus; Influenza A Virus, H1N1 Subtype; influenza virus vaccine; inhibitor/antagonist; insight; Interferon Type I; Interferons; Leukocytes; Link; Lung; Lung diseases; macrophage; macrophage product; Matrix Metalloproteinases; Morbidity - disease rate; mortality; Mus; nanobodies; Neutrophil Collagenase; new therapeutic target; novel; Oseltamivir; pandemic disease; Pathogenesis; Patients; Plasma; Population; Pre-Clinical Model; prevent; Proteins; Regimen; response; safety testing; seasonal influenza; Severities; small molecule; Stimulus; System; Testing; Therapeutic Effect; therapeutic evaluation; therapeutic target; Time; Toxic effect; Treatment Efficacy; Vaccinated; Vaccines; Viral; Viral Load result; Viral Proteins; Virus; Virus Diseases; Virus Replication; ","MMP-8 Deficiency Improves Host Responses to  Influenza Viral Infections","147437","ZRG1","Special Emphasis Panel ","","","02","68987","","68987",""
"9854037","U54","AG","1","N","05/20/2020","09/01/2019","08/31/2020","","U54AG062322","","RFA-OD-19-013","1U54AG062322-01A1","NIA:269591\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE ON AGING","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","CAREER ENHANCEMENT CORE NARRATIVE The Brigham/ Harvard Career Enhancement Core (CEC) will train, support and engage the next generation of investigators in sex differences research in stress, sleep, neural regulation, and health outcomes. The CEC will also impact the wider SCORE and national community through Travel Exchange Fellowships and public dissemination of methods and best practices.","1947225; ","REXRODE, KATHRYN M;","","","","Address; Affect; Aging; Award; Basic Science; Biological; Biology; body system; cardiometabolism; Cardiovascular Diseases; career; Clinical Research; Cognition; Collaborations; Communities; Dementia; Development; Discipline; Disease; education research; education resources; educational atmosphere; Educational process of instructing; Elements; Evaluation; Faculty; Fellowship; Fostering; Funding; Future; Gender; Goals; Grant; Growth; Health; health difference; Hospitals; Impaired cognition; Infrastructure; innovation; Institution; Interdisciplinary Study; investigator training; Knowledge; Leadership; Learning; Measurement; medical schools; Medicine; Mentors; Mentorship; Methodology; Methods; Mission; neuromechanism; neuroregulation; Neurosciences; next generation; Outcome; Participant; Pilot Projects; Population Research; Postmenopause; Predisposition; programs; Publications; Reproducibility; reproductive senescence; Research; Research Infrastructure; Research Methodology; Research Personnel; Resources; Role; Science; SECTM1 gene; sex; Sex Differences; Site; skill acquisition; skills; Sleep; Stress; Structure; Training; Training Programs; Training Support; Travel; United States National Institutes of Health; Visit; webinar; Woman; Women's Health; Work; ","Career Enhancement Core","062322","ZRG1","Special Emphasis Panel ","7956","A1","01","172014","97577","","269591"
"9916629","R01","CA","5","N","05/18/2020","05/01/2020","04/30/2021","395","R01CA197098","SCHOOLS OF MEDICINE","PA-13-302","5R01CA197098-05","NCI:359202\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","STONY BROOK","UNITED STATES","PATHOLOGY","01","804878247","US","5992612","STATE UNIVERSITY NEW YORK STONY BROOK","NY","117943362","PUBLIC HEALTH RELEVANCE: This project will help to develop a new paradigm in our current understanding of the tumor biology as it relates to miR-129 function in colorectal cancer. This, in turn, may lead to the development of novel targeted therapies to colon cancer stem cells and enhance our understanding of chemoresistance in cancer, which fits the scope of the National Cancer Institute's mission to eliminate cancer.","2086793; ","JU, JINGFANG ;","KONDAPAKA, SUDHIR B","05/04/2016","04/30/2021","3-Dimensional; Acute; Apoptosis; Apoptotic; Azoxymethane; base; BCL-2 Protein; Binding; biobank; cancer cell; Cancer Etiology; cancer stem cell; Carcinogens; CD44 gene; Cell Cycle; Cell Cycle Regulation; Cell Death; Cell Line; Cells; chemotherapy; clinically relevant; Colon; colon cancer cell line; colon cancer patients; Colon Carcinoma; colon tumorigenesis; Colonic Neoplasms; Colorectal Cancer; colorectal cancer progression; Coupled; Development; Dextran Sulfate; Disease Progression; Ectopic Expression; Epigenetic Process; Epithelial Cells; Event; Failure; fluoropyrimidine; Fluorouracil; Gene Expression; Genes; Genotoxic Stress; HCT116 Cells; Human; In Vitro; in vivo; Investigation; knock-down; Knockout Mice; Knowledge; Lead; Leucovorin; LGR5 gene; Liquid Chromatography; Liver; Malignant Neoplasms; Mediating; men; Messenger RNA; Methylation; MicroRNAs; Mission; Modeling; Molecular; mortality; mouse model; Mus; nanoscale; National Cancer Institute; Neoplasm Metastasis; neoplastic cell; new therapeutic target; novel; novel therapeutic intervention; Operative Surgical Procedures; Organoids; overexpression; oxaliplatin; Pathologic; Pathway interactions; Patients; Primary Neoplasm; promoter; Proteins; Proteomics; public health relevance; Regulator Genes; Resistance; resistance mechanism; response; Role; Specimen; Spectrometry, Mass, Electrospray Ionization; subcutaneous; SW480; SW620; Testing; Thymidylate Synthase; tumor; Tumor Biology; tumor microenvironment; Tumor Stem Cells; Tumor Suppressor Proteins; Tumor Tissue; tumor xenograft; tumorigenesis; United States; Universities; Untranslated RNA; Woman; Xenograft procedure; ","Roles of miR-129 in colorecal cancer","197098","BMCT","Basic Mechanisms  of Cancer Therapeutics Study Section ","","","05","228750","130452","359202",""
"9947999","R01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","233","R01HL130468","","PA-13-302","5R01HL130468-06","NHLBI:740371\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BRONX","UNITED STATES","","14","081266487","US","10053556","ALBERT EINSTEIN COLLEGE OF MEDICINE","NY","104611900","NARRATIVE Obstructive sleep apnea syndrome is a common and difficult to treat disorder in obese children and leads to significant medical consequences. We still do not understand why some obese children suffer from this disorder while other do not. The current study will use advance imaging analytical tools combined with biomechanical models to better understand the causes of the disorder and ways to improve outcomes of treatment in these children.","8435581 (contact); 1881840; 3167382; ","ARENS, RAANAN  (contact); UDUPA, JAYARAM K; WOOTTON, DAVID M;","LAPOSKY, AARON D","08/15/2016","04/30/2021","17 year old; 3-Dimensional; analytical tool; Anatomy; Architecture; Area; Arousal; automated segmentation; awake; base; biomechanical model; Biomechanics; Body mass index; Body Weight Changes; Body Weight decreased; Breathing; cardiometabolism; Cardiovascular system; Characteristics; Child; Childhood; Clinical; Computer Models; Continuous Positive Airway Pressure; Development; Diagnosis; Dilator; Disease; Drops; Epidemic; Goals; High Prevalence; high risk; Image; imaging biomarker; imaging modality; improved outcome; Individual; individual variation; insight; Intercept; Intervention; Liquid substance; longitudinal design; Machine Learning; Magnetic Resonance Imaging; Maps; Measurement; Measures; Mechanics; Medical; Metabolic; Minority; Modeling; Motion; Muscle; Nasopharynx; Neurocognitive; non rapid eye movement; novel; Obesity; obesity in children; Object Attachment; Obstructive Sleep Apnea; Oropharyngeal; Outcome; Performance; pharyngeal critical pressure; Population; pressure; Prevalence; Property; Residual state; respiratory; response; Risk; ROC Curve; Severities; Shapes; Sleep; standard care; Structure; Techniques; Three-Dimensional Image; Time; Tissues; Tonsil; tool; Treatment outcome; treatment response; ","A Computational Biomechanical Airway Model for Obese Children at Risk for OSAS","130468","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","","06","575630","164741","740371",""
"9961479","R33","AI","5","N","05/21/2020","01/01/2020","11/30/2020","855","R33AI121692","","RFA-AI-14-066","5R33AI121692-05","NIAID:525456\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SOUTH SAN FRANCISCO","UNITED STATES","","14","116815074","US","10053588","PYLUM BIOSCIENCES, INC.","CA","940806218","PUBLIC HEALTH RELEVANCE: Clostridium difficile is a leading cause of nosocomial infections worldwide and is responsible for an estimated 250,000-400,000 hospitalizations and 14,000 deaths per year in the US alone. This project aims to develop a modified R-type bacteriocin (Avidocin-CD), or a cocktail of up to three Avidocin-CDs, effective at preventing C. difficile infection (CDI) relapses caused by 80% or more of known C. difficile toxigenic isolates prevalent in North America. These anti-bacterial agents will be used in secondary prophylaxis to prevent or eliminate C. difficile re-infection in 'cured' CDI patients by targeting and specificall killing vegetative C. difficile bacteria that remain or try to re-establish in the gut.","9482383; ","SCHOLL, DEAN M;","RANALLO, RYAN","01/28/2019","11/30/2020","Acute; acute symptom; Americas; Animal Model; animal safety; Anti-Bacterial Agents; Antibiotics; associated symptom; Bacteria; Bacterial Infections; bactericide; bacteriocin; Bacteriophages; Binding; Binding Proteins; Biological Assay; c new; cell envelope; Cells; Cessation of life; clinically relevant; Clostridium difficile; colonization resistance; Data; Databases; Detection; Development; Disease; disorder later incidence prevention; Dose; Engineering; Exposure to; Fiber; Formulation; Generations; genetic variant; gut microbiota; Hospitalization; improved; Incidence; Individual; Infection; Libraries; manufacturing process; Medical; meetings; microbiota; Mus; Myoviridae; Nature; No-Observed-Adverse-Effect Level; North America; Nosocomial Infections; novel; pathogen; Patients; Phage Receptors; Phase; Population; pre-clinical; Preclinical Testing; prevent; Production; programs; prophylactic; Prophylactic treatment; protein complex; Proteins; public health relevance; Puncture procedure; Rattus; receptor binding; Recurrence; Relapse; Reproduction spores; resistance mechanism; Ribotypes; Safety; safety study; Structure; Surface; Tail; Testing; Therapeutic; transmission process; Vancomycin; Virulent; ","Title: Development of Modified R-type Bacteriocins to Specifically Target C. difficileand Prevent Relapse of CDIs.","121692","ZAI1","Special Emphasis Panel ","","","05","296868","228588","525456",""
"9908063","R01","DK","5","N","05/18/2020","04/01/2020","03/31/2021","847","R01DK105442","SCHOOLS OF ARTS AND SCIENCES","PA-16-160","5R01DK105442-04","NIDDK:456843\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","LOS ANGELES","UNITED STATES","BIOCHEMISTRY","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","Project Narrative The intestinal epithelium provides a selective barrier that permits nutrient and water transport, while preventing uptake of harmful environmental toxins and microbial contamination of interstitial tissues. Aging results in loss of intestinal barrier function across species; however, the increased vulnerability to intestinal dysfunction in older individuals is not well understood. Our work to characterize the mechanisms underlying the age-related loss in intestinal barrier function and its relationship to changes in intestinal stem cell behavior has implications for the development of new strategies to treat bowel diseases that arise from increased inflammation and/or associated with loss of intestinal integrity, including Crohn's disease, ulcerative colitis, and colon cancer.","1938226; ","JONES, DANA LEANNE;","GREENWEL, PATRICIA","04/01/2017","03/31/2021","Acute; Adult; Age; age related; aged; Aging; analog; Animals; Apical; Arthropods; Biological Assay; Blood; cell age; cell behavior; Cell Differentiation process; Cell Proliferation; Cells; Chronic; Colon Carcinoma; Complex; Crohn's disease; Data; Daughter; Defect; Degenerative Disorder; Development; Disease; Drosophila genus; Drosophila melanogaster; dysbiosis; Embryo; Enterocytes; Enteroendocrine Cell; Epidermal Growth Factor Receptor; Epithelial; Epithelium; Event; fly; Functional disorder; Gastrointestinal tract structure; Gene Expression; Genes; gliotactin; healthspan; Hindgut; Homeostasis; Human; Immunity; Individual; Inflammation; innate immune function; Intercellular Junctions; interstitial; Intestinal Diseases; intestinal epithelium; intestinal homeostasis; Intestinal permeability; Intestines; Life; Liver; Longevity; loss of function; macromolecule; Maintenance; Malignant Neoplasms; Mammals; Mass Spectrum Analysis; Mediating; Metabolic; microbial; Midgut; Modeling; Molecular; Muscle; Natural regeneration; neuroglian; novel; Nutrient; organ regeneration; Pathway interactions; Phenotype; Play; prevent; Proteins; Regulation; RNA Interference; Role; Septate; Signal Transduction; Skin; Stem Cell Factor; stem cell niche; Stem cells; Structure; Surface; Testing; Tight Junctions; Time; tissue regeneration; Tissues; Toxic Environmental Substances; Ulcerative Colitis; uptake; Vertebrates; Water; Work; ","Regulation of intestinal stem cell behavior by occluding junctions","105442","CMAD","Cellular Mechanisms in Aging and Development Study Section ","","","04","306969","149874","456843",""
"9932119","F31","AT","5","N","05/19/2020","05/16/2020","05/15/2021","213","F31AT010419","SCHOOLS OF PHARMACY","PA-18-671","5F31AT010419-02","NCCIH:45520\","TRAINING, INDIVIDUAL","2020","National Center for Complementary & Integrative Health","","Chicago","UNITED STATES","PHARMACOLOGY","07","098987217","US","577703","UNIVERSITY OF ILLINOIS AT CHICAGO","IL","606124305","While natural products have been a successful source of new medicines, current methods to find new drug-leads provide inadequate prioritization and result in unmanageable rates of compound rediscovery. This project seeks to build an innovative framework to maximize the taxonomic and chemical diversity of natural product libraries while minimizing the number of microbial strains entering the pipeline. The successful completion of this project will lessen the effort and resources needed to build, screen, and maintain a diverse bacterial natural products library and address a major unmet need in natural product drug discovery and microbiome analysis.","14923000; ","CLARK, CHASE MADISON;","HOPP, CRAIG","05/16/2019","05/15/2021","16S ribosomal RNA sequencing; Address; Agriculture; Algorithms; Bacteria; base; Botanicals; Chemicals; Collection; Complex; Computer software; Custom; Data; Databases; design; Development; drug discovery; Environment; Fingerprint; Fresh Water; Funding; Future; Generations; Geography; Grouping; Hour; Human; Human Microbiome; Individual; Injections; innovation; Intelligence; Libraries; Location; Medicine; Metabolic; Metabolism; Methods; microbial; microbiome; microbiome analysis; microbiome research; Mind; Morphology; Natural Product Drug; Natural Products; novel therapeutics; Pattern; Phylogenetic Analysis; Phylogeny; Plants; Porifera; programs; Proteomics; Research; Research Personnel; Resources; sample collection; Sampling; Science; Scientist; Seeds; Services; Source; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; success; Taxonomy; Techniques; Technology; Testing; tool; Variant; Visualization; Work; ","A New Paradigm in Developing Microbial Libraries for Drug Discovery","010419","ZAT1","Special Emphasis Panel ","","","02","45520","","45520",""
"9990426","F32","HD","1","N","05/15/2020","04/01/2020","03/31/2021","865","F32HD102214","SCH ALLIED HEALTH PROFESSIONS","PA-19-188","1F32HD102214-01","NICHD:65310\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","Chicago","UNITED STATES","OTHER HEALTH PROFESSIONS","07","098987217","US","577703","UNIVERSITY OF ILLINOIS AT CHICAGO","IL","606124305","Project Narrative Long-term walking impairments after stroke reduce community involvement, ability to perform activities of daily living, health status, and quality of life. The proposed work will improve our understanding of how the brain controls lower limb movement after stroke, especially in regards to the contribution of the non-lesioned hemisphere to movement of the affected leg. These results will help optimize rehabilitation strategies for improving walking, thereby improving community ambulation and quality of life while reducing healthcare burden.","15827215; ","CLELAND, BRICE THOMAS;","MARDEN, SUSAN F","04/01/2020","03/31/2023","Activities of Daily Living; Address; Adjuvant; Affect; Ankle; Bilateral; career; Characteristics; chronic stroke; Clinical; Communities; community involvement; Contralateral; experience; Fellowship; Foundations; Future; Goals; Health; Health Status; Healthcare; Impaired health; Impairment; improved; Individual; insight; Intervention; Investigation; Ipsilateral; Isometric Contraction; Isometric Exercise; kinematics; Knowledge; Leg; Lesion; limb movement; Limb structure; Lower Extremity; Measurement; Measures; mind control; Motor; motor control; Motor Evoked Potentials; motor impairment; Motor Pathways; motor rehabilitation; Movement; Muscle; neurophysiology; neuroregulation; Oranges; Outcome; Paresis; Participant; Physical activity; Physiologic pulse; Population; post stroke; Quality of life; recruit; rehabilitation strategy; Rehabilitation therapy; Research; Research Personnel; response; Rest; spatiotemporal; Specificity; Stroke; stroke rehabilitation; stroke survivor; Testing; tibialis anterior muscle; Transcranial magnetic stimulation; Translating; Upper Extremity; Walking; walking rehabilitation; walking speed; Work; ","Contribution of the non-lesioned hemisphere to lower limb movement and walking function after stroke","102214","ZRG1","Special Emphasis Panel ","","","01","65310","","65310",""
"9999877","D43","TW","2","N","05/19/2020","05/19/2020","01/31/2021","989","D43TW010060","SCHOOLS OF MEDICINE","PAR-19-283","2D43TW010060-06","FIC:177002\NICHD:50000\NIMH:75000\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","CHAPEL HILL","UNITED STATES","INTERNAL MEDICINE/MEDICINE","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","PROJECT NARRATIVE The Malawi HIV integrated treatment and prevention guidelines have recently adopted evidence- based interventions including Dolutegravir based antiretroviral therapy, Pre-Exposure prophylaxis and integrated service delivery but require implementation science research to bring the interventions to scale for maximum impact. The University of North Carolina (UNC), the University of Malawi, College of Medicine (COM), Kamuzu College of Nursing (KCN) and Ministry of Health (MOH) will build upon nearly two decades of experience in HIV training activities and institutional research capacity strengthening in Malawi to expand HIV implementation science skills among research-focused faculty at COM, KCN, MOH and partner affiliates. Our program will develop both investigators and strengthen systems in the COM and KCN to assist the Malawi government to conduct high quality implementation science.","6414614 (contact); 8103632; ","HOSSEINIPOUR, MINA CHRISTINE (contact); MWAPASA, VICTOR ;","BANSAL, GEETHA PARTHASARATHY","05/15/2015","01/31/2025","Area; Award; base; career development; Caring; college; Complement; design; Discipline; Discipline of Nursing; Doctor of Philosophy; economic evaluation; Educational workshop; Ensure; Environment; Evolution; experience; Faculty; Family Practice; Feedback; Funding; global health; Goals; Grant; Guidelines; Health; HIV; implementation research; implementation science; implementation strategy; Institution; Interdisciplinary Study; Internships; Lead; Leadership; Malawi; Medicine; Mentors; mHealth; Modeling; next generation; North Carolina; pre-exposure prophylaxis; Prevention; Prevention strategy; Preventive therapy; programs; Public Health; Research; Research Personnel; Research Support; Scientist; Services; Structure; Teacher Professional Development; Time; Training; Training Activity; Training Programs; Universities; Writing; ","Malawi HIV Implementation Research Scientist Training Program (M-HIRST)","010060","ZRG1","Special Emphasis Panel ","","","06","285038","16964","302002",""
"10135529","R01","GM","3","N","05/22/2020","06/01/2019","05/31/2020","859","R01GM109194","SCHOOLS OF ARTS AND SCIENCES","PA-18-591","3R01GM109194-06S1","NIGMS:224213\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","PASADENA","UNITED STATES","NONE","27","009584210","US","1073501","CALIFORNIA INSTITUTE OF TECHNOLOGY","CA","911250001","Narrative Equipment Administrative Supplement - Not applicable","1881551; ","FU, GREGORY C;","YANG, JIONG","05/15/2014","05/31/2022","Administrative Supplement; Copper; Equipment; Nitrogen; parent grant; Reaction; Research; ","Photoinduced, Copper-Catalyzed Substitution Reactions of Alkyl Electrophiles by Nitrogen Nucleophiles","109194","SBCB","Synthetic and Biological Chemistry B Study Section ","","S1","06","224213","","224213",""
"9937160","P01","AG","2","N","05/22/2020","04/01/2020","03/31/2021","","P01AG002132","","PAR-18-297","2P01AG002132-39","NIA:121063\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","2415454; ","PRUSINER, STANLEY B;","","","","Accounting; Aging; Budgets; Collaborations; Collection; Communication; Complex; Disease; Goals; Grant; Manuscripts; Measures; meetings; Monitor; Neurodegenerative Disorders; Outcome; Preparation; Program Research Project Grants; programs; Quality Control; Reporting; Schedule; Services; success; Universities; Work; ","Core A: Administrative Core","002132","ZAG1","Special Emphasis Panel ","6191","","39","75000","46063","","121063"
"10148141","U54","EB","3","N","05/22/2020","05/21/2020","05/20/2021","286","U54EB015408","","PAR-17-453","3U54EB015408-07S2","NIBIB:7055078\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Projects Narrative: Just as the mandate for primary care is growing with an aging population and an increase in people afflicted by chronic disease, the number of primary care providers is shrinking. This imbalance puts huge constraints on primary care capacity, limiting access and fragmenting care, jeopardizing health outcomes by delaying treatment, and complicating follow-up regarding treatment recommendations. The use of appropriately-designed point-of-care technologies in primary care environments will address these problems by increasing the capacity of primary care physicians to care for more patients and help them achieve better health.","8614812 (contact); 10286550; ","PARRISH, JOHN A (contact); SCHACHTER, STEVEN ;","LASH, TIFFANI BAILEY","05/21/2020","05/20/2021","Address; aging population; Area; Award; care providers; Care Technology Points; Caring; Chronic Disease; Clinical; clinical application; Clinical Research; Collaborations; commercialization; design; Elements; Emerging Technologies; Engineering; Environment; experience; follow-up; Funding; Goals; Hand; Health; Health Alliance; Health Technology; Healthcare; Hospitals; improved; industry partner; innovation; innovative technologies; Institution; Interdisciplinary Study; International; Laboratories; Licensing; Medicine; meetings; Methodology; Military Medicine; Modeling; National Institute of Biomedical Imaging and Bioengineering; Outcome; Patients; Performance; point of care; Primary Care Physician; Primary Health Care; Process; prototype; Recommendation; Research; Resources; Scientist; Singapore; Site; Speed; Students; Technology; Testing; Training; Translational Research; Translations; U-Series Cooperative Agreements; Universities; ","Point of Care Technology Research Center in Primary Care","015408","ZEB1","Special Emphasis Panel ","","S2","07","4199451","2855627","7055078",""
"10017290","R01","HL","5","N","05/20/2020","04/01/2020","03/31/2021","837","R01HL130591","","PA-13-302","5R01HL130591-05","NHLBI:619461\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","WARWICK","UNITED STATES","","02","069855195","US","10052778","KENT COUNTY MEMORIAL HOSPITAL","RI","028862770","NARRATIVE This WHISH-2-Prevent Heart Failure study will evaluate whether randomization to a physical activity and strength training intervention will reduce the risk of Heart Failure and its burden in 49,936 elderly women who have the greatest risk of developing heart failure. In addition, it will perform a dose finding analysis to determine the type, frequency and intensity of physical activity that lead to reduced risk of heart failure in elderly women.      ","1912659; ","EATON, CHARLES B;","COOPER, LAWTON S","08/01/2016","03/31/2021","Accelerometer; Acute; Adverse effects; adverse outcome; Aerobic; Age; age effect; Aging; Ancillary Study; Atherosclerosis; atherosclerosis risk; Attenuated; base; Behavioral; cardiorespiratory fitness; Cardiovascular system; Cessation of life; Clinical; Communication; comorbidity; cost effective; Disease; Dose; Educational Intervention; EFRAC; Elderly; Elderly woman; epidemiology study; Etiology; Exercise; exercise capacity; exercise intervention; Exercise Tolerance; experience; frailty; Frequencies; Funding; Heart failure; Heart Rate; high risk population; Hospitalization; improved; Incidence; indexing; Individual; Intervention; intervention effect; Lead; light intensity; men; middle age; Morbidity - disease rate; mortality; muscle strength; novel; Observational Study; older women; Outcome; outcome forecast; Physical activity; physical inactivity; Physiological; Population; pragmatic trial; preservation; prevent; Prevention trial; Preventive; Primary Prevention; prospective; Public Health; Randomized; Recurrence; Risk; Risk Factors; sedentary; sedentary lifestyle; Skeletal Muscle; strength training; Techniques; Testing; Time; Treatment Failure; Woman; Women's Health; ","WHISH-2-Prevent Heart Failure Study","130591","CHSB","Cancer, Heart, and Sleep Epidemiology B Study Section ","","","05","545637","73824","619461",""
"10005532","R01","HL","3","N","05/20/2020","05/20/2020","06/30/2020","837","R01HL063043","SCHOOLS OF MEDICINE","PA-18-586","3R01HL063043-20S1","NHLBI:30273\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","COLUMBUS","UNITED STATES","PHYSIOLOGY","03","832127323","US","6218701","OHIO STATE UNIVERSITY","OH","432101016","PROJECT NARRATIVE: Public Health Significance: Cardiac arrhythmias (abnormal heart rhythms) remain a leading cause of death in the United States. While much has been learned about the causes of these arrhythmias in single cells from the heart, there remain questions about how events in individual cells cause the heart to malfunction. We seek to better understand arrhythmias with the long-term goal of improving arrhythmia prevention and treatment.","6186799; ","GYORKE, SANDOR ;","TJURMINA, OLGA A","09/20/1999","06/30/2023","Affect; Animal Model; Arrhythmia; Automobile Driving; base; Biological; Calcium; Calcium Signaling; calmodulin-dependent protein kinase II; Canis familiaris; Cardiac; Cardiac Myocytes; Cardiomyopathies; Catecholaminergic Polymorphic Ventricular Tachycardia; Cause of Death; Cells; Characteristics; clinically relevant; Comparative Study; Complex; Couples; Coupling; Defect; Development; Disease; Event; Funding; Genetic; Genetic Models; Goals; Heart; Heart Abnormalities; Heart Atrium; heart cell; Heart Diseases; heart rhythm; high resolution imaging; Homeostasis; Human; Image; improved; in vivo; Individual; Mechanics; Mediating; Membrane Potentials; Modeling; Molecular; Morbidity - disease rate; mortality; mouse model; Mus; Muscle Cells; Myocardial; Myocardial tissue; Nature; Neurons; novel therapeutic intervention; overexpression; Pharmacology; Phase; Population; Preparation; prevent; Prevention; Process; Property; Public Health; Refractory; Research; Resolution; Role; Ryanodine Receptors; RyR2; Sarcoplasmic Reticulum; SERCA2a; Site; sudden cardiac death; Testing; Therapeutic; Time; Tissues; United States; uptake; Variant; Ventricular; Work; ","Controlled and Uncontrollable Calcium release in heart","063043","","","","S1","20","19406","10867","30273",""
"10144867","U19","AI","3","N","05/18/2020","05/18/2020","07/31/2020","855","U19AI128913","SCHOOLS OF MEDICINE","PA-18-591","3U19AI128913-03S1","NIAID:869489\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","PATHOLOGY","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","PROJECT NARRATIVE Characterization of the immune response to SARS-CoV-2 virus using a set of high-throughput CORE technologies, epigenetics, immune function assays and novel statistical and computational approaches will permit us to advance the field by describing immunologic characteristics that are associated with COVID-19 disease. We will also determine immune correlates of COVID-19 disease severity as reflected by measures of critical illness.","1867400 (contact); 7748143; ","REED, ELAINE F (contact); SARWAL, MINNIE M;","ROBIEN, MARK ANDREW","05/18/2020","07/31/2021","2019-nCoV; antigen-specific T cells; antiviral immunity; base; Biological Assay; Biometry; Cessation of life; Characteristics; Clinical; clinical phenotype; Clonality; Computer Models; Coupled; COVID-19; Critical Illness; Cytomegalovirus; Data; Development; Disease; DNA Methylation; Epigenetic Process; experience; Frequencies; Immune; immune function; Immune response; Immunologics; Immunology; Infection; Intubation; Kidney Transplantation; Measures; Mechanics; Morbidity - disease rate; mortality; novel; novel diagnostics; Outcome; Patients; Pneumonia; prevent; Resources; respiratory; Respiratory Failure; Respiratory Signs and Symptoms; Severity of illness; Syndrome; System; T-cell receptor repertoire; Technology; Therapeutic; Time; Transplant Recipients; Upper Respiratory Infections; Viral Antigens; Virus; Virus Diseases; ","Mapping Immune Responses to CMV in Renal Transplant Recipients - Clinical Core","128913","","","","S1","03","557365","312124","869489",""
"10051129","R01","AR","3","N","05/21/2020","07/01/2019","06/30/2020","846","R01AR057374","","PA-18-914","3R01AR057374-07S1","NIAMS:266477\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","The bone morphogenetic protein (BMP) and transforming growth factor b (TGFb) are potent regulators of normal bone development as well as inappropriate (heterotopic) bone formation. The naturally occurring ligands of this pathway are promiscuous in their binding with multiple receptors, and have poor pharmacokinetics, limiting their utility as probes of function or as potential drug molecules. This proposal develops novel reagents that can initiate or modulate signaling of BMP and TGFb with high specificity and potency, and may thus be able to target intended tissues with greater selectivity, and with the potential for rapid translation as therapeutic molecules.","1860889; ","YU, PAUL B;","CHEN, FAYE H","07/01/2019","06/30/2021","activin A; Activins; ACVR1 gene; Affect; Antibodies; arthropathies; base; Binding; bone; Bone Development; bone morphogenetic protein receptor type I; Bone Morphogenetic Proteins; Burn injury; Complement Factor B; Development; Drug Kinetics; gain of function; Genetic; genetic approach; Heterotopic Ossification; Human; in vivo; Inflammatory; insight; Joints; Ligands; Modification; Molecular; Morbidity - disease rate; Morphologic artifacts; Mus; Muscle; Musculoskeletal Diseases; mutant; non-genetic; novel; Operative Surgical Procedures; Orthopedics; Osteogenesis; Pain; parent grant; Pathway interactions; Pharmaceutical Preparations; Pharmacology; progressive myositis ossificans; Reagent; receptor; Replacement Arthroplasty; Rodent; Signal Pathway; Signal Transduction; Skeletal Muscle; soft tissue; Specificity; Syndrome; Tendon structure; Therapeutic; tissue culture; tissue regeneration; Tissue Therapy; Tissues; tool; Transforming Growth Factor beta; Transforming Growth Factors; Translating; Translations; Trauma; validation studies; Work; Wound Healing; ","Novel probes of BMP and TGF-beta signaling and function","057374","","","","S1","07","148870","117607","266477",""
"9917740","R01","CA","5","N","05/22/2020","05/01/2020","04/30/2021","396","R01CA214062","SCHOOLS OF MEDICINE","PA-16-160","5R01CA214062-04","NCI:570047\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","HANOVER","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","02","041027822","US","2021601","DARTMOUTH COLLEGE","NH","037551421","Narrative. Targeting of immune negative checkpoint regulator (NCR) pathways is revolutionizing the treatment of human cancers and has established that these pathways are proven clinical targets in human disease. VISTA (V-region Immunoglobulin-containing Suppressor of T cell Activation), is a recently- identified, NCR ligand/receptor that is being developed as a target for human malignancies. Clinical trials with aVISTA antibodies have commenced. This proposal will define how VISTA controls the immune system to make protective immune responses to cancer and may help us to understand who will benefit the most from anti-VISTA therapy. Understanding how targeting this molecule cures cancer will provide guidance for future therapeutic applications in oncology.","1864181 (contact); 2089699; ","NOELLE, RANDOLPH J. (contact); TURK, MARY JO ;","KUO, LILLIAN S","05/01/2017","04/30/2022","Ablation; Accounting; Address; Algorithms; Antibodies; Antibody Therapy; base; Bioinformatics; Bone Marrow; Cell Culture Techniques; Cell physiology; Cells; Cellular biology; chemokine; Chemotaxis; Clinic; Clinical; clinical development; Clinical Trials; cohort; colon cancer patients; Colon Carcinoma; Colorectal Cancer; Combined Modality Therapy; Correlative Study; CTLA4 gene; cytokine; Data; design; Development; Elements; Evaluation; Family; Family member; Future; Gene Expression Profiling; Genetic; genetic technology; Genomics; granulocyte; Hematopoietic; Hematopoietic Neoplasms; Human; human disease; Image Analysis; Imaging technology; Immune; immune checkpoint; immune function; Immune response; Immune system; Immune Targeting; Immunity; Immunoglobulins; immunological status; immunoregulation; Immunosuppression; Immunosuppressive Agents; Immunotherapeutic agent; Impairment; improved; in vivo; Infiltration; Investigation; Knock-in Mouse; Knockout Mice; Knowledge; Leukocytes; Ligands; Malignant Neoplasms; Mediating; Mediator of activation protein; member; Mission; Modeling; monocyte; mouse model; mRNA Expression; multiplexed imaging; Mus; Myelogenous; Myeloid Cells; Myeloid-derived suppressor cells; Myeloproliferative disease; neoplasm immunotherapy; Neoplasm Metastasis; neoplastic cell; novel; oncology; Outcome; Pathway interactions; patient stratification; PD-1 blockade; Phase; pleiotropism; predictive marker; prevent; Production; programmed cell death protein 1; protein expression; Proteins; receptor; Reporting; Resistance; Resolution; Role; sound; Spatial Distribution; Suppressor-Effector T-Lymphocytes; System; T-Cell Activation; T-Lymphocyte; targeted treatment; Testing; Therapeutic; Time; transcriptome sequencing; tumor; tumor growth; Tumor Immunity; tumor microenvironment; Tumor Suppression; Tumor-associated macrophages; Up-Regulation; ","Targeting VISTA eradicates large, established PD-1/CTLA-4 resistant tumors","214062","ZRG1","Special Emphasis Panel ","","","04","351881","218166","570047",""
"10131480","U01","DK","3","N","05/21/2020","02/01/2020","01/31/2021","847","U01DK057135","SCHOOLS OF MEDICINE","RFA-DK-15-501","3U01DK057135-21S1","NIDDK:70875\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","PHILADELPHIA","UNITED STATES","PSYCHIATRY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","PUBLIC HEALTH RELEVANCE: Weight loss is recommended for overweight and obese individuals with type 2 diabetes, but the long-term effects of such approaches on the issues of greatest concern to older individuals --including mortality, health care utilization and costs, diabetic complications, quality of life, and frailty -- remain untested. The Look AHEAD-Extension will follow approximately 3800 of these individuals for an additional 4.5 years to determine whether random assignment to an intensive lifestyle intervention focused on weight loss achieved through healthy eating and increased physical activity relative to a control group leads to improved long-term health in later life. This extended follow-up will provide important information about the long-term beneficial effects of a lifestyle intervention in a growing segment of the population-namely those who are older, overweight or obese, and have type 2 diabetes.","8223144; ","WADDEN, THOMAS A.;","KUCZMARSKI, ROBERT J","09/30/1999","01/31/2021","Address; adult obesity; Age; Age-Years; Aging; Ancillary Study; Biochemical; Body Weight decreased; Bone Density; Cardiovascular Diseases; Caring; Clinic Visits; Clinical; Clinical Trials; cohort; comorbidity; Complications of Diabetes Mellitus; Control Groups; cost; cost effective; Data; Data Analyses; Diabetes Mellitus; diabetic; Dimensions; Disease; Education; Elderly; Event; Face; Fatty acid glycerol esters; follow-up; frailty; functional disability; Genetic; Goals; group intervention; Guidelines; Health; Health Care Costs; health care service utilization; Healthcare; healthy aging; Healthy Eating; improved; Incidence; Independent Living; Individual; Infrastructure; Intervention; Kidney Diseases; Lead; Life; lifestyle intervention; Long-Term Effects; Longevity; Measures; medical complication; Microvascular Dysfunction; middle age; mortality; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; outcome prediction; Overweight; Participant; Pathway interactions; Patient-Focused Outcomes; Persons; Phase; Physical activity; Physical Function; Population; post intervention; primary outcome; Process; programs; Public Health; public health relevance; Publications; Quality of life; Randomized; Randomized Controlled Clinical Trials; randomized trial; Recording of previous events; Reporting; Research Project Grants; research study; resilience; secondary outcome; Subgroup; Telephone; Testing; Thinness; trial comparing; Uncontrolled Study; Weight; Weight Gain; ","10/16 Action for Health in Diabetes Extension Study Research Project","057135","ZDK1","Special Emphasis Panel ","","S1","21","43750","27125","70875",""
"10159109","I01","VA","5","N","05/17/2020","03/01/2020","02/28/2021","999","I01HX002287","","RFA-HX-17-005","5I01HX002287-03","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","INDIANAPOLIS","UNITED STATES","","07","608434697","US","481029","RLR VA MEDICAL CENTER","IN","462022803","This research will help the VA understand how to design technologies to aid medication management and patient safety, particularly for Veterans that receive care from both VA and non-VA healthcare providers. This study will generate a set of guidelines on how to design technologies to support providers' information needs for the coordination of medications. These guidelines will be shared with VA operations and informatics leaders and will foster a more standardized information display across VA Medical Centers nationwide. We anticipate that healthcare organizations inside and outside the VA will be able to apply these guidelines to develop more effective information displays for medication management. Study findings can be used to increase providers' adoption of technologies, enhance medication coordination, reduce medication errors, and improve the quality and safety of care for Veterans.","2056956; ","WEINER, MICHAEL ;","","03/01/2018","02/28/2022","Accountability; Adoption; Adverse drug event; Caring; Clinical; Cognition; Cognitive; cognitive process; Conflict (Psychology); Consumption; Data; Data Display; data exchange; Decision Making; design; Ensure; Environment; evidence base; Fostering; Foundations; Geography; Goals; Guidelines; Health; health care service organization; Health Personnel; Healthcare; Human; improved; Informatics; information display; Inpatients; Institution; Interview; Investigation; Investments; Knowledge; Medical; Medical center; Medication Errors; Medication Management; medication safety; Methods; novel; operation; Outcome Measure; Outpatients; Patient risk; patient safety; Patients; Performance; Pharmaceutical Preparations; Pharmacists; Process; Process Measure; programs; prototype; Provider; Psyche structure; Randomized Controlled Trials; Reporting; Research; Risk; Safety; satisfaction; simulation; Standardization; Techniques; Technology; Testing; Time; tool; Translating; usability; Veterans; virtual; Workload; ","A Human Factors Investigation of Health Information Exchange: Tools to Support Providers? Coordination of Medications","002287","HS3A","Healthcare Informatics Special Emphasis Panel ","","","03","","","",""
"10007279","R43","DK","1","N","05/22/2020","05/22/2020","05/21/2021","847","R43DK125126","","PA-19-272","1R43DK125126-01","NIDDK:300000\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","LEESBURG","UNITED STATES","","10","836065008","US","10038636","GLYCOMANTRA, INC.","VA","201765645","Project Narrative Galectin-3 (Gal3) promotes insulin resistance of type 2 diabetes by interacting with the insulin receptor (IR). The objective of this project is to use a natural high affinity Gal3 antagonist to restore insulin sensitivity by interfering Gal3-IR interactions.","8247170; ","AHMED, HAFIZ ;","JONES, TERESA L Z","05/22/2020","05/21/2021","Adipocytes; Adult; Affinity; Agreement; American; Animal Model; base; Binding; Biological Markers; Blood; Body Weight; Cause of Death; cell bank; Cells; Clinical Trials; Data; Diabetes Mellitus; Diet; Disease; Dose; Engineering; experimental study; Fat-Restricted Diet; Fatty acid glycerol esters; Female; Frequencies; Future; Galactose Binding Lectin; Galectin 3; Gene Proteins; Genetic; Glucose Intolerance; glucose tolerance; glucose uptake; Goals; Heart Diseases; Hepatocyte; High Fat Diet; Hormones; Immune; immunoregulation; impaired glucose tolerance; improved; indexing; Inflammation; Inflammatory; Insulin; Insulin Receptor; Insulin Resistance; insulin sensitivity; insulin signaling; insulin tolerance; Investigational Drugs; Licensing; Ligands; Link; Liver; loss of function; macrophage; male; Malignant Neoplasms; Measures; Mediating; Metabolic syndrome; Modeling; mouse model; Mus; Muscle; Muscle Cells; Names; Non-Insulin-Dependent Diabetes Mellitus; novel; Obese Mice; Obesity; Outcome Study; Pancreas; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; phase 1 study; Phase I Clinical Trials; Play; Prediabetes syndrome; primary endpoint; Production; Publications; Publishing; Receptor Activation; Receptor Signaling; Research; Resolution; restoration; Role; Signal Transduction; Source; Technology; Testing; Therapeutic; Time; Toxic effect; United States; ","Targeting galectin-3 to overcome insulin resistance in type 2 diabetes","125126","ZRG1","Special Emphasis Panel ","","","01","","","300000",""
"9922229","P01","AG","5","N","05/22/2020","05/01/2020","04/30/2021","","P01AG031719","","PAR-13-258","5P01AG031719-10","NIA:465140\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","DURHAM","UNITED STATES","","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","This competing revision project focuses on investigating ?Sex difference in effects of genetics & GxE interactions on elderly cognition, mental health and survival?, based on analyzing genotype/phenotype data from the Chinese Longitudinal Healthy Longevity Surveys (CLHLS), as well as replicative and comparative analyses across Chinese, Whites and African Americans using the CLHLS, U.S. Health and Retirement Survey and Singapore Chinese Health Survey datasets. We aim to contribute to future health promotion programs considering male and female individual differences in genetic characteristics, in order to increase the efficiency of the interventions. Our expanded PPG with this competing revision project is highly relevant to public health.","6369108; ","ZENG, YI ;","","","","Affect; African American; Age; age group; Alzheimer disease prevention; Alzheimer's Disease; Attention; base; Behavior Therapy; Behavioral; Biological; Candidate Disease Gene; Categories; caucasian American; Cause of Death; Centenarian; Characteristics; Chinese American; Chinese People; Cognition; Cognitive; Communities; comparative; Constitution; Country; Data; Data Set; database of Genotypes and Phenotypes; Dementia; Demography; Deposition; Diet Habits; Dietary Intervention; DNA; Elderly; Environment; Environmental Health; Environmental Risk Factor; Female; follow-up; Future; gene environment interaction; Genes; Genetic; genetic analysis; genetic profiling; genetic variant; genome wide association study; Genotype; Health; health difference; Health Promotion; Health Surveys; healthy aging; Human; in silico; Individual; Individual Differences; Interdisciplinary Study; International; Intervention; Knowledge; Literature; Longevity; longitudinal database; Longitudinal Surveys; male; male health; Measures; Mental Health; Methods; mortality; Nonagenarian; Outcome; Participant; Pathway interactions; phenotypic data; physical conditioning; Pilot Projects; Population; programs; Public Health; Published Comment; Publishing; Recovery; Reporting; Research; Retirement; Risk; Sampling; Scientist; sex; Sex Differences; Sex Functioning; Singapore; social; social engagement; social interventions; Social status; Statistical Models; Stress; Surveys; Testing; United States National Institutes of Health; Women's Health; Work; ","Sex differences in effects of genetics & GxE interactions on elderly cognition, mental health and survival","031719","ZAG1","Special Emphasis Panel ","5428","","10","317888","147252","","465140"
"10056169","R21","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R21AI148836","SCHOOLS OF MEDICINE","PA-19-053","1R21AI148836-01A1","NIAID:189375\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ALBUQUERQUE","UNITED STATES","GENETICS","01","829868723","US","10021612","UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR","NM","871310001","PROJECT NARRATIVE Dengue virus (DENV) is a mosquito-borne virus that can result in potentially fatal hemorrhagic fever. With over half of the world?s population at risk of infection, a vaccine that can prevent serious complications is desperately needed. Our goal is to use a novel bacteriophage virus-like particle platform to elicit antibodies that can safely block the activity of DENV non-structural protein 1 (NS1), a protein that contributes to the progression to severe complications.","11407658; ","FRIETZE, KATHRYN ;","WOODSON, SARA ELAINE","05/21/2020","04/30/2022","Aedes; Antibodies; Antibody Response; Antibody titer measurement; Antigens; Antiviral Agents; autoreactivity; Bacteriophages; base; Binding; Biological Assay; Blood; Blood Platelets; Blood Vessels; Caring; Cells; Characteristics; cross reactivity; cytokine; Dangerousness; Data; Dengue; Dengue Infection; Dengue Vaccine; Dengue Virus; design; Developing Countries; Development; Disease; efficacy testing; Endothelial Cells; Engineering; Epitopes; experimental study; Extravasation; Flavivirus; Goals; high reward; high risk; Human; Immune; Immunization; Immunize; immunogenic; In Vitro; in vivo; in vivo evaluation; Individual; Infection; infection risk; interest; Knowledge; Lead; Length; Mediating; Mosquito Control; mosquito-borne; mouse model; Mus; Nonstructural Protein; novel; novel vaccines; Pathogenesis; Pathogenicity; Peptides; Peripheral Blood Mononuclear Cell; Plasma; Populations at Risk; preclinical development; prevent; Prevention; Production; Proteins; Publishing; Recombinants; Research; response; Risk; RNA Phages; Role; Safety; safety testing; Serotyping; Serum; Small RNA; Structure; Subunit Vaccines; Testing; Tight Junctions; Vaccinated; vaccine candidate; vaccine safety; Vaccines; Vascular Endothelial Cell; vector control; Viral; Viral Hemorrhagic Fevers; Virus; Virus Diseases; Virus-like particle; ","Bacteriophage virus-like particle vaccines against dengue virus non-structural protein 1","148836","IHD","Immunity and Host Defense ","","A1","01","125000","64375","189375",""
"9915964","R01","HL","5","N","05/18/2020","05/01/2020","04/30/2021","837","R01HL142711","","PA-18-484","5R01HL142711-02","NHLBI:544954\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Characterizing the genetic basis of plasma lipids has spurred many key paradigms for preventing cardiovascular disease ? biological insights, risk prediction, and medicines. Whole genome sequencing now offers the prospect of identifying all the potential genetic factors influencing lipids. However, for an individual genome, interpretation is limited by knowledge gaps regarding 1) ethnic differences, and 2) understanding the genome outside (98.5%) of protein-coding regions (1.5%), so we seek to complement whole genome sequence analysis with genomic variation characterization in humans and cells using new technological, statistical, and bioinformatic approaches. The goal is to improve risk prediction and tailored preventive care as well as find new genes, which can be therapeutically targeted to reduce the prevalence of cardiovascular disease.","11848064 (contact); 11444136; ","NATARAJAN, PRADEEP  (contact); PELOSO, GINA MARIE;","MINEAR, MOLLIE A","05/01/2019","04/30/2024","Algorithms; Alleles; Architecture; base; Bioinformatics; Biological; Biological Assay; Biology; cardiometabolism; Cardiovascular Diagnostic Techniques; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cells; Cellular Assay; Cholesterol; Clinical; Code; cohort; Complement; Complex; Coronary heart disease; CRISPR/Cas technology; Data; Diagnosis; Diagnostic; Discrimination; Disease; ethnic difference; ethnic diversity; Ethnic Origin; European; Evaluation; exome sequencing; Familial Hypercholesterolemia; functional genomics; Gene Frequency; Generations; Genes; Genetic; genetic analysis; Genetic Code; Genetic Determinism; Genetic screening method; Genetic Transcription; genetic variant; Genome; genome editing; genome sequencing; genomic variation; Genomics; Genotype; Goals; heart disease risk; Hepatocyte; Heritability; High Density Lipoprotein Cholesterol; Human; hypercholesterolemia; improved; in silico; In Vitro; in vitro Assay; in vivo; Individual; Inherited; innovation; insight; Knowledge; LDL Cholesterol Lipoproteins; Leadership; Lipids; Medical Genetics; Medicine; method development; Methodology; Modeling; Molecular Profiling; National Heart, Lung, and Blood Institute; Nature; novel; Open Reading Frames; Phenotype; phenotypic data; Plasma; pleiotropism; Population; Positioning Attribute; premature; Prevalence; prevent; Prevention; Preventive care; programs; public health relevance; rare variant; Reporter; Research; Research Personnel; Risk; Risk Factors; Sample Size; Sequence Analysis; success; Technology; Testing; Therapeutic; therapeutic target; trait; Trans-Omics for Precision Medicine; transcriptomics; Triglycerides; Untranslated RNA; Variant; Whole Blood; whole genome; Work; ","Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids","142711","GHD","Genetics of Health and Disease Study Section ","","","02","469097","75857","544954",""
"10102304","P30","CA","3","N","05/20/2020","05/15/2020","11/30/2020","353","P30CA023108","SCHOOLS OF MEDICINE","PAR-17-095","3P30CA023108-41S1","NCI:137804\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","HANOVER","UNITED STATES","PEDIATRICS","02","041027822","US","2021601","DARTMOUTH COLLEGE","NH","037551421","Project Narrative Among the fifty states, New Hampshire ranks number one in the incidence of breast, esophageal, and urinary bladder cancers, the latter reflecting the association between bladder cancer and environmental arsenic exposure linked to frequent use of rural well water within the ?Granite State?. Of similar concern, Vermont ranks number one in the incidence of uterine cancer and second in the incidence of melanoma. Norris Cotton Cancer Center continues to create important new knowledge, engage our community, and influence public policy related to these and other cancers in a manner directly relevant to these unique catchment area public health needs.","1899930; ","LEACH, STEVEN D;","BELIN, PRECILLA L","08/04/1997","11/30/2024","Adopted; anticancer research; Area; Arsenic; Authorship; Biological; Breast; Cancer Biology; cancer care; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Immunology Science; cancer immunotherapy; cancer prevention; career; Caring; Catchment Area; Characteristics; Clinic; Clinical; Clinical Trials; college; Communities; Community Outreach; Continuity of Patient Care; design; Development; Education; Education and Outreach; Engineering; Entrepreneurship; Esophagus; Evaluation; experience; Faculty Recruitment; faculty research; Frequencies; Funding; Genomics; granite; Growth; health care delivery; health equity; Health Promotion; Health system; Immunology; Immunooncology; Incidence; innovation; Institution; interdisciplinary collaboration; Investigational Therapies; investigator-initiated trial; Investments; Knowledge; Lead; Leadership; Link; Malignant neoplasm of urinary bladder; Malignant Neoplasms; Medical; medical schools; melanoma; member; Mission; Molecular Epidemiology; New Hampshire; Norris Cotton Cancer Center; novel; Parents; Pathology; Patients; Phase; Population; Population Heterogeneity; Population Sciences; precision oncology; prevent; Prevention; programs; Public Health; Public Policy; Publications; Research; Research Infrastructure; Research Support; Research Training; Resource Sharing; Rural; Rural Population; Schools; Science; Site; Strategic Planning; survivorship; Therapeutic; Trace Elements; Translating; Translational Research; United States National Institutes of Health; Update; Uterine Cancer; Vermont; well water; ","Cancer Center Support Grant","023108","NCI","Subcommittee I - Transistion to Independence ","","S1","41","84027","53777","137804",""
"10063249","P30","CA","3","N","05/18/2020","04/01/2020","03/31/2021","397","P30CA014599","SCHOOLS OF MEDICINE","PAR-17-095","3P30CA014599-45S1","NCI:114999\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","CHICAGO","UNITED STATES","INTERNAL MEDICINE/MEDICINE","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","NARRATIVE The mission of the UCCCC is to elucidate the determinants of cancer, to develop cures for cancer, and to prevent cancer. In addition, we provide education and training for basic scientists, physicians, and clinical investigators, and local health professionals, as well as develop and implement community-based cancer education and outreach programs. Our mission is fulfilled in an environment that values diversity, the development of the next generation of physicians and scientists, and delivering comprehensive and compassionate patient care.","1884022; ","LE BEAU, MICHELLE M;","SHAFIK, HASNAA","09/01/1997","03/31/2023","Address; animal imaging; Antibodies; anticancer research; Area; Award; base; Basic Science; Bioinformatics; Biological; Biological Markers; Biometry; Cancer Burden; cancer care; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Cancer Diagnostics; cancer education; Cancer Etiology; cancer genetics; cancer health disparity; Cancer Immunology Science; Cancer Model; Cancer Patient; cancer prevention; Cancer Research Project; cancer risk; career; Catchment Area; Chicago; Classification; Clinical; clinical care; Clinical Data; Clinical Investigator; Clinical Protocols; Clinical Research; Clinical Sciences; Clinical Treatment; Clinical Trials; Cohort Studies; Collaborations; colorectal cancer screening; Communities; Community Outreach; Comprehensive Cancer Center; Conduct Clinical Trials; cooking; County; Cyclic GMP; Cytometry; data management; data registry; Development; diagnostic biomarker; Diagnostic Procedure; drug development; Education; effective intervention; effective therapy; embryonic stem cell; Environment; Environmental Risk Factor; ethnic minority population; Evaluation; experience; Faculty; Funding; Future; Genetic; genetic approach; Genomics; Goals; Head and Neck Cancer; Health; Health Professional; Hematologic Neoplasms; high risk behavior; high risk population; Hospitals; Human; human tissue; Illinois; Image; Imaging Techniques; Immune; Immunologic Monitoring; improved; Incidence; Indiana; individual patient; innovation; Intervention; Investigation; Investigational Drugs; Investigational Therapies; investigator-initiated trial; Laboratories; Lead; Leadership; male; Malignant Neoplasms; Medical; Medicine; member; Methods; metropolitan; Microscopy; Minority Groups; Mission; Modality; Modeling; Molecular; Monitor; mortality; mortality disparity; multidisciplinary; next generation; novel; novel diagnostics; novel strategies; novel therapeutics; oncology; Outcome; outreach; outreach program; Patient Care; patient population; Pediatric Oncology Group; Peer Review; Pharmacogenomics; Pharmacology; Phase; Physicians; Population; Population Sciences; Population Sizes; pre-clinical; prevent; Prevention; Preventive; Process; profession allied to medicine; programs; Protocols documentation; Publications; Quality of life; Research; Research Personnel; Research Project Grants; Resistance; Resource Sharing; Resources; Risk; Scientist; Site; Smoking; Strategic Planning; Students; survivorship; System; Technology; Testing; Therapeutic; Therapeutic procedure; tissue resource; Training; Training and Education; Transgenic Mice; Translational Research; treatment program; treatment response; tumor; tumor registry; Underrepresented Minority; Underrepresented Populations; underserved minority; Universities; Woman; ","Cancer Center Support Grant","014599","NCI","Subcommittee I - Transistion to Independence ","","S1","45","70987","44012","114999",""
"9852898","P20","GM","1","N","05/21/2020","12/01/2019","11/30/2020","","P20GM130448","","PAR-18-266","1P20GM130448-01A1","NIGMS:766117\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MANHATTAN","UNITED STATES","","01","929773554","US","4202801","KANSAS STATE UNIVERSITY","KS","665062504","","9625748; ","RICHT, JUERGEN A.;","","","","Achievement; Advisory Committees; Animal Model; Applications Grants; Area; Award; Biology; Biomedical Research; career development; Cellular biology; Centers of Research Excellence; Chemicals; Cognitive; Collaborations; Collection; Committee Members; Communicable Diseases; Core Facility; Development; Development Plans; Disease Pathway; Ecosystem; Educational workshop; Emerging Communicable Diseases; Ensure; experience; Extramural Activities; Faculty; faculty mentor; Feedback; Funding; Future; Goals; graduate student; Grant; Growth; Head; Human Resources; Idaho; improved; Individual; Infectious Diseases Research; Infrastructure; interest; International; Kansas; Knowledge; laboratory facility; Manuscripts; Medical center; member; Mentors; Mission; Missouri; Molecular Analysis; Molecular Biology; Multiple Partners; Nebraska; Neurobiology; novel strategies; operation; pathogenic microbe; Pathology; Phase; Play; Policies; Postdoctoral Fellow; Principal Investigator; Procedures; Productivity; programs; protein structure function; recruit; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; responsible research conduct; Role; Secure; Seeds; Series; success; symposium; Technology; TimeLine; Training; Training Programs; United States National Institutes of Health; Universities; virology; Work; Writing; Zoonoses; ","Administrative Core","130448","ZGM1","Special Emphasis Panel ","7576","A1","01","504025","262092","","766117"
"10162929","U01","AI","3","N","05/19/2020","05/19/2020","12/31/2020","855","U01AI110397","","PA-18-591","3U01AI110397-05S1","NIAID:211342\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BOSTON","UNITED STATES","","07","076593722","US","1504801","BOSTON CHILDREN'S HOSPITAL","MA","021155724","PROJECT NARRATIVE The supplement to the parent grant is to leverage the cohort to participate in the multi-center survey entitled Human Epidemiology and Response to SARS-CoV-2 (HEROS), study. This study can be rapidly implemented and realistically conducted without necessitating any visits to a clinical research center. In addition to the need for surveying children for asymptomatic SARS-CoV-2 infection, this study will allow a comparison between children with asthma and other atopic conditions and children without those conditions through remote surveys and collection of samples. This study is an unprecedented, high impact opportunity to leverage the parent trial within in scope in understanding how SARS-C0V-2 differentially affects children with the condition of interest, compared to children without it.","2099802; ","PHIPATANAKUL, WANDA ;","DAVIDSON, WENDY F","05/19/2020","12/31/2020","2019-nCoV; Adult; Affect; Air; American; Asthma; base; Boston; Child; Clinical Research; Clinical Trials; cohort; Communicable Diseases; COVID-19; educational atmosphere; Effectiveness; elementary school; environmental intervention; epidemiologic data; Epidemiology; Exposure to; Goals; Home environment; Hour; Human; improved; Infection; Infrastructure; inner city; interest; Intervention; Intervention Studies; Lung diseases; Molds; Morbidity - disease rate; mouse allergen; parent grant; Parents; particulate pollutant; response; sample collection; Schools; Severe Acute Respiratory Syndrome; Source; Students; Surveys; Symptoms; Testing; Time; virology; Visit; ","School Inner-City Asthma Intervention Study : Human Epidemiology and Response to SARS-COV-2 (HEROS) Supplement","110397","","","","S1","05","119402","91940","211342",""
"9928521","R01","NS","5","N","05/21/2020","05/01/2020","04/30/2021","853","R01NS073717","SCHOOLS OF MEDICINE","PA-18-345","5R01NS073717-07","NINDS:616754\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","CLEVELAND","UNITED STATES","OTHER BASIC SCIENCES","11","135781701","US","10000858","CLEVELAND CLINIC LERNER COM-CWRU","OH","441950001","PROJECT NARRATIVE This project will determine the disease altering properties of high intensity exercise by randomizing 250 individuals with PD across two study sites (Cleveland Clinic and University of Utah) into a high-intensity home- based cycling program or a usual and customary care control group. Both groups will be monitored over a 12- month period; motor and non-motor outcomes will be measured via standardized clinical assessments and biomechanical-based iPad applications to determine disease altering characteristics of aerobic exercise. The development of a model to predict the effectiveness of high intensity aerobic exercise based on patient-specific factors (demographic information, demographics, and disease variables) will facilitate widespread patient- specific exercise prescription.","6067052; ","ALBERTS, JAY L.;","LUNGU, CODRIN ION","09/01/2011","04/30/2024","Address; Aerobic; Aerobic Exercise; Age; Age of Onset; Animal Model; base; Behavioral; Biomechanics; Blinded; Caring; Characteristics; Clinic; Clinical; Clinical assessments; cognitive performance; cohort; comorbidity; Control Groups; Coupled; Data; demographics; Development; Disease; Disease Progression; Effectiveness; Enrollment; Evaluation; executive function; Exercise; exercise intensity; exercise intervention; exercise prescription; exercise program; Future; Gait; Gait speed; Gender; Healthcare; Heart Rate; heart rate variability; Home environment; Human; illness length; Image; improved; Individual; information processing; Intervention; Investigation; Laboratories; Lower Extremity; Measures; Modeling; Monitor; Motor; motor control; motor function improvement; Movement Disorders; Neuraxis; neurotrophic factor; Operative Surgical Procedures; Outcome; Parkinson Disease; Participant; Patient Recruitments; Patient-Focused Outcomes; Patients; Pattern; Performance; performance tests; Periodicity; Persons; Pharmaceutical Preparations; Pharmacologic Substance; Phenotype; predicting response; predictive modeling; preservation; primary outcome; processing speed; programs; Property; Protocols documentation; Quality of life; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recommendation; Short-Term Memory; Site; Societies; Standardization; Sum; Supervision; Symptoms; Testing; Time; Trail Making Test; Translations; United States National Institutes of Health; Universities; Upper Extremity; Utah; wearable sensor technology; Work; ","CYClical Lower Extremity exercise for Parkinsons trial (CYCLE Trial)","073717","MRS","Musculoskeletal Rehabilitation Sciences Study Section ","","","07","462668","154086","616754",""
"9923641","K23","DK","5","N","05/18/2020","05/01/2020","04/30/2021","847","K23DK101492","SCHOOLS OF MEDICINE","PA-14-049","5K23DK101492-05","NIDDK:145530\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","CLEVELAND","UNITED STATES","INTERNAL MEDICINE/MEDICINE","11","077758407","US","218601","CASE WESTERN RESERVE UNIVERSITY","OH","441061712","PUBLIC HEALTH RELEVANCE: Patients transitioning from transplantation to dialysis face a variety of complex medical and psychosocial challenges. End-stage renal disease following failure of a previously transplanted kidney is prevalent and associated with high costs, morbidity and mortality. Barriers to effective care for patients with failed kidney transplants have not been examined systematically. Assessing these patients' experiences and identifying barriers to quality care will facilitate the development of targeted interventions that may lead to improved quality of life and reduced morbidity and mortality","10990247; ","HUML, ANNE MARIE;","RANKIN, TRACY L","07/19/2016","04/30/2021","Address; Affect; Aftercare; American; Anemia; Back; barrier to care; Blood Vessels; Bone Diseases; care outcomes; Caring; Categories; Catheters; Chronic; Clinical; Clinical Markers; comorbidity; Complex; cost; Data; Development; Dialysis procedure; Dose; Education; End stage renal failure; experience; Exposure to; Face; Failure; Focus Groups; Future; Hemodialysis; high risk; Hospitalization; Illinois; Immunosuppressive Agents; improved; Indiana; Inferior; innovation; Intervention; Intervention Trial; Interview; Kentucky; Kidney Diseases; Kidney Failure; Kidney Transplantation; Knowledge; Lead; Medical; Methods; Minerals; Modality; Modeling; Morbidity - disease rate; mortality; Nephrology; nutrition; Ohio; Outcome; Patient Care; patient population; Patients; Pharmaceutical Preparations; Principal Investigator; Process; prospective; Prospective cohort study; Provider; psychosocial; Psychosocial Factor; Psychosocial Stress; public health relevance; Qualitative Research; Quality of Care; Quality of life; Registries; Research Design; Research Methodology; Research Personnel; Retrospective cohort study; Risk; Self Management; Structure; Surveys; systematic review; Techniques; Training; Transplantation; trial design; Uncertainty; Work; ","Barriers to Care for Patients Transitioning from Transplant to Dialysis","101492","DDK","Kidney, Urologic and Hematologic Diseases D Subcommittee ","","","05","134750","10780","145530",""
"9916804","R01","MH","5","N","05/19/2020","04/01/2020","03/31/2021","242","R01MH100027","SCHOOLS OF MEDICINE","RFA-HD-17-008","5R01MH100027-13","NIMH:2750081\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","LOS ANGELES","UNITED STATES","NONE","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","Project Narrative This Network of Investigators proposes to fill a significant gap in autism research by recruiting underserved subjects of self-reported African ancestry (African-Americans), an important population that has not previously been well represented in ASD genetics. We will enrich current genetic repositories and use comprehensive methods to find genes, while at the same time improving disparities by facilitating early diagnosis through our study to increase access to care for this population.","1882597; ","GESCHWIND, DANIEL H;","DUTKA, TARA","03/25/2013","03/31/2023","admixture mapping; Adult; African; African American; Age; autism spectrum disorder; Awareness; base; Behavior; Biocompatible Materials; Bioinformatics; Biological; Biological Markers; Brain; Calendar; Child; Childhood; Chromatin Structure; Classification; Clinical; clinical care; Code; cohort; Cohort Studies; Communities; Consensus; cost; Data; data exchange; data pipeline; de novo mutation; Detection; Development; Developmental Gene; Diagnosis; Diagnostic; Diagnostic Services; Dideoxy Chain Termination DNA Sequencing; disorder risk; Early Diagnosis; endophenotype; Ethnic Origin; Etiology; European; Event; Family; Family member; follow-up; Frequencies; Functional disorder; Funding Agency; Future; gene discovery; Gene Expression Profiling; Gene Expression Regulation; Genes; Genetic; genetic analysis; Genetic Diseases; Genetic Enhancement; Genetic Research; genetic resource; Genetic Risk; genetic risk factor; Genetic screening method; Genetic study; genetic variant; Genetic Variation; Genome; genome sequencing; genome-wide; Goals; health disparity; Health Services Accessibility; Heritability; Human; Improve Access; improved; Individual; innovation; insertion/deletion mutation; instrument; Interview; Knowledge; lymphoblast; Maps; Measures; member; Methods; MicroRNAs; National Institute of Mental Health; Network-based; neuropsychiatry; novel; Nucleotides; open data; Outcome; Parents; Pathogenicity; Pathway Analysis; Pathway interactions; Patient Self-Report; Patients; Phase; Phenotype; Play; Population; Population Heterogeneity; population stratification; Predisposition; proband; Publishing; Quantitative Trait Loci; rare variant; Recording of previous events; recruit; Recurrence; repository; Research; Research Personnel; Research Subject Recruitments; Resolution; Resources; Risk; Risk Factors; risk sharing; risk variant; RNA analysis; RNA Splicing; Role; Sample Size; Sampling; Services; Severities; sex; Siblings; Single Nucleotide Polymorphism; Site; social; standard measure; Structure; Susceptibility Gene; Symptoms; Syndrome; Testing; Time; transcriptome sequencing; transmission process; Underrepresented Populations; Untranslated RNA; Update; Variant; Visual; visual tracking; whole genome; Work; ","Autism Genetics Phase II: Increasing representation of human diversity","100027","ZRG1","Special Emphasis Panel ","","","13","2302326","447755","2750081",""
"9922299","P20","GM","5","N","05/22/2020","04/01/2020","03/31/2021","859","P20GM103440","SCHOOLS OF MEDICINE","PAR-14-233","5P20GM103440-18","NIGMS:3473589\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","PHARMACOLOGY","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","PUBLIC HEALTH RELEVANCE (provided by applicant): This project continues the development of the Nevada IDeA Network of Biomedical Research Excellence (NV INBRE) initiated in 2005. The project will link all Nevada public universities and colleges and the state' only private liberal arts college in a network to share expertise and resources. We will increase biomedical research in the state by funding new research projects, supporting a Bioinformatics Core that provides computational power and support for genome analysis, and mentoring students enrolled in 2- and 4-year programs for education and careers in research investigating Cell Growth and Differentiation. In addition, the NV INBRE will renovate laboratory space at Nevada State College to enable students to participate in biomedical research projects.","8897571; ","BAKER, JONATHAN E.;","ARORA, KRISHAN","09/01/2001","03/31/2021","Arts; Basic Science; big biomedical data; Big Data to Knowledge; Bioinformatics; Biomedical Research; bridge program; career; cell growth; Clinical Research; college; Communication; curriculum development; Data; Development; Differentiation and Growth; Disease; Education; Enrollment; Evaluation; Experimental Designs; experimental study; Faculty; faculty mentor; Funding; genome analysis; genome wide association study; Grant; Institution; Knowledge; Laboratories; Link; Mentors; Nevada; next generation sequencing; outreach; outreach program; Pathway Analysis; Privatization; programs; Proteomics; public health relevance; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resources; Science; Services; Statistical Data Interpretation; student mentoring; Students; Technology; Training; undergraduate student; Underrepresented Students; Universities; Work; ","Nevada IDeA Network of Biomedical Research Excellence (INBRE)","103440","ZGM1","Special Emphasis Panel ","","","18","3128353","345236","3473589",""
"9852902","P20","GM","1","N","05/21/2020","12/01/2019","11/30/2020","","P20GM130448","","PAR-18-266","1P20GM130448-01A1","NIGMS:239039\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MANHATTAN","UNITED STATES","","01","929773554","US","4202801","KANSAS STATE UNIVERSITY","KS","665062504","Project Narrative: The life history of many human pathogens, including several emerging infectious diseases, include significant dynamics occurring in environmental reservoirs. We aim to understand if these dynamics influence the pathogenesis of recently emerged Shiga toxin producing Shigella flexneri.","10798993; ","PLATT, THOMAS GENE;","","","","Amoeba genus; Animals; Cells; Communicable Diseases; Complex; cost; Cost Measures; Costs and Benefits; diarrheal disease; Emerging Communicable Diseases; Ensure; Environment; Eukaryota; Event; Evolution; Exotoxins; experience; experimental study; fitness; Gene Expression; Genes; Genotype; Hemorrhagic colitis; Heterogeneity; Human; human pathogen; Lead; life history; Maintenance; Mediating; Molecular; Molecular Evolution; mutant; Mutation; novel; pathogen; Pathogenesis; Pathogenicity; Phenotype; Plasmids; Population; Predatory Behavior; pressure; Production; Public Health; Regulon; Research; Research Personnel; Role; Shiga Toxin; Shigella; Shigella dysenteriae; Shigella flexneri; Shigella Infections; Shigella sonnei; System; Testing; Tetrahymena thermophila; transmission process; Virulence; Virulence Factors; waterborne; Work; Zoonoses; ","Host and Aquatic Environment Dependent Cost and Benefits of the Shigella Flexneri Virulence Plasmid and Shiga Toxin Production","130448","ZGM1","Special Emphasis Panel ","7580","A1","01","159973","79066","","239039"
"9852903","P20","GM","1","N","05/21/2020","12/01/2019","11/30/2020","","P20GM130448","","PAR-18-266","1P20GM130448-01A1","NIGMS:241666\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MANHATTAN","UNITED STATES","","01","929773554","US","4202801","KANSAS STATE UNIVERSITY","KS","665062504","Project Narrative: Emerging and zoonotic infectious diseases (EZIDs) cause global heath devastation and are difficult to study due to lack of established laboratory tools and genetics for certain pathogens. We propose to use bacteria of the genus Legionella as model pathogens to reveal novel host immune defense mechanisms that can be used to combat EZIDs.","15189870; ","SHAMES, STEPHANIE ROCHELLE;","","","","Address; Aerosols; Alveolar Macrophages; Animal Model; Attenuated; attenuation; Bacteria; Bacterial Infections; Bacterial Proteins; Biochemistry; Cells; Cellular biology; combat; Communicable Diseases; contaminated water; cytokine; Cytokine Receptors; Cytosol; Data; Defense Mechanisms; Detection; Disease; Disease Outbreaks; disorder prevention; Etiology; Event; experimental study; Extravasation; fitness; Flagellin; Genetic; Genetic Techniques; global health; Goals; Homologous Gene; Host Defense; Host Defense Mechanism; Human Activities; human pathogen; Image; Immune; immune activation; immune clearance; Immune Evasion; Immune response; Immune system; Immunity; Immunologic Receptors; Immunologics; Immunology; Impairment; Infection; Infectious Agent; Inflammatory; Inhalation; Innate Immune System; innovation; insight; Integration Host Factors; Investigation; Laboratories; Legionella; Legionella longbeachae; Legionella pneumophila; Legionnaires' Disease; Lipids; Lung; macrophage; Mammals; Mediating; Methods; Modeling; Molecular; mouse model; Mus; novel; novel therapeutics; Outcome; pathogen; Pathogen detection; Pathogenesis; pathogenic bacteria; pathogenic microbe; Pathogenicity; Pathway interactions; Persons; Phagocytes; Prevalence; prevent; Proteins; Proteomics; Protozoa; Public Health; Research; Respiratory physiology; response; Salvelinus; Signal Transduction; System; targeted treatment; Testing; Therapeutic; Therapeutic Intervention; therapy development; tool; transmission process; treatment strategy; Type IV Secretion System Pathway; United States National Institutes of Health; Virulence; Virulent; Work; Zoonoses; ","Mechanisms of Effector-mediated Host Defense","130448","ZGM1","Special Emphasis Panel ","7581","A1","01","161701","79965","","241666"
"9928037","K23","DA","5","N","05/18/2020","05/01/2020","04/30/2021","279","K23DA039341","SCHOOLS OF MEDICINE","PA-14-049","5K23DA039341-05","NIDA:196560\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","ANN ARBOR","UNITED STATES","EMERGENCY MEDICINE","12","073133571","US","1506502","UNIVERSITY OF MICHIGAN AT ANN ARBOR","MI","481091276","PUBLIC HEALTH RELEVANCE: The proposed project fills a critical gap in our understanding of the daily relationships between substance use and high-risk firearm behaviors, including firearm carriage under the influence of drugs and alcohol, firearm- related threats and violent firearm use, among youth with a history of substance misuse and firearm possession. This project will collect and analyze such daily data, using it to develop a technology-enhanced, remote-therapist delivered behavioral intervention that can be applied to high-risk youth seeking Emergency Department care and decrease their substance use and high-risk firearm behavior. An effective intervention may reduce the significantly high rates of substance use and youth violence observed among youth in low- resource urban communities.","10985250; ","CARTER, PATRICK MICHAEL;","LAO, GUIFANG","05/01/2016","04/30/2021","Accident and Emergency department; Address; Adolescent; adolescent substance use; adverse outcome; African American; Age; Aggressive behavior; Alcohol consumption; alcohol measurement; Alcohol or Other Drugs use; Alcohols; Assessment tool; base; Behavior; Behavior assessment; Behavior Therapy; career; Cellular Phone; Charge; Cognitive; cognitive skill; Communities; control trial; craving; Crime; Criminal Justice; Data; Data Analyses; Data Collection; design; Development; effective intervention; Emergency Care; Emergency department visit; Emergency Situation; Emerging Technologies; Enhancement Technology; experience; Fellowship; Fibrinogen; Firearms; Frequencies; Funding; Future; Goals; group intervention; gun violence; Health; health care settings; health disparity; Health Services Accessibility; high risk; Homicide; Illicit Drugs; improved; innovation; Intervention; intervention effect; Intervention Trial; K-Series Research Career Programs; Laws; Literature; longitudinal analysis; Longitudinal cohort study; Longitudinal Studies; marijuana use; Mentors; Mentorship; Methods; Minority; misuse of prescription only drugs; Moods; Motivation; motivational enhancement therapy; multidisciplinary; Outcome; Ownership; Participant; peer; Persons; Pharmaceutical Preparations; Population; prevent; Primary Health Care; prospective; psychologic; Public Health; public health relevance; Randomized; Recording of previous events; reduced substance use; Research; Research Personnel; Resources; responsible research conduct; Risk; Schools; secondary analysis; Services; Severities; skills; smartphone Application; socioeconomic disadvantage; substance misuse; System; Tablet Computer; Technology; Teenagers; Testing; theories; Therapeutic; therapy development; Time; tool; Training; treatment as usual; trend; usability; Violence; Violent injury; weapons; Youth; youth violence; ","M-Health to Decrease Youth Substance Misuse & High Risk Illegal Firearm Behaviors","039341","ZRG1","Special Emphasis Panel ","","","05","182000","14560","196560",""
"9922226","P01","AG","5","N","05/22/2020","05/01/2020","04/30/2021","","P01AG031719","","PAR-13-258","5P01AG031719-10","NIA:279362\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","DURHAM","UNITED STATES","","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","Women have longer life expectancy than men in all countries of the world, but they tend to report poorer self- rated health and have higher disability levels. We have collected human and primate data to provide insight into the potential universality of this male-female health-survival paradox with a special emphasis on the importance of social position as well as underlying human diseases assessed on the basis of causes of death.","6457567; ","CHRISTENSEN, KAARE ;","","","","Age; Alcohol consumption; Cancer Patient; Cause of Death; China; Complement; Complex; Coronary heart disease; Country; crosslink; Data; data resource; Data Set; Demography; Denmark; disability; Economics; experience; Female; female fertility; Gender; Health; health difference; Health Status; Heart Diseases; Human; human data; human disease; Incidence; Income; insight; Japan; Life; Life Expectancy; Life Style; Light; Literature; male; male health; Malignant Neoplasms; Medical; men; Morbidity - disease rate; mortality; Onset of illness; Patients; Pharmaceutical Preparations; Politics; Population; Primates; Reporting; Research; response; Russia; sex; Sex Differences; Shock; social; Social Conditions; Social Gradients; Social status; Societies; Sociology; study population; Surveys; Testing; Time; Tobacco use; trend; USSR; Utah; Woman; Women's Health; Work; ","Project 2","031719","ZAG1","Special Emphasis Panel ","8037","","10","262270","17092","","279362"
"10156834","U01","AI","3","N","05/20/2020","05/20/2020","06/30/2020","855","U01AI069918","SCHOOLS OF MEDICINE","PA-20-135","3U01AI069918-14S1","NIAID:152652\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BALTIMORE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","PROJECT NARRATIVE Urgent COVID-19 questions need answers. We propose using the NA-ACCORD research infrastructure to support our infectious disease epidemiologists and clinical co-investigators as they pivot to answer urgent COVID-19 questions about testing, risk factors for hospitalization with COVID-19, the risk of angiotensin- converting enzymes (ACE) inhibitors or angiotensin II type-I receptor blockers (ARBs) with more severe COVID-19 disease, and the impact of the healthcare system?s adaptation to COVID-19 on people who have a chronic condition that requires routine care (such as HIV). Using data from 2 existing cohorts of people with and without HIV and 3 new cohorts following people with COVID-19 (regardless of their HIV status), we will generate evidence to answer these urgent COVID-19 questions.","8730879; 1872991 (contact); ","ALTHOFF, KERI NICOLE; MOORE, RICHARD DOUGLAS (contact);","ZIMAND, LORI B","05/20/2020","06/30/2021","2019-nCoV; Acquired Immunodeficiency Syndrome; Adult; Age; Algorithms; American; American Heart Association; Americas; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; base; Biological; Calendar; Canada; Cardiology; Cardiovascular Diseases; Caring; CD4 Lymphocyte Count; Centers for Disease Control and Prevention (U.S.); Cessation of life; China; Chinese People; Chronic; Chronic lung disease; Clinical; cohort; Collaborations; college; Communicable Diseases; Communities; comorbidity; Coronavirus; COVID-19; Data; Data Analytics; Data Collection; data management; data sharing; data tools; Diabetes Mellitus; Disease; Elderly; Electronic Health Record; Enrollment; Epidemic; Epidemiologist; Ethnic Origin; Geographic Locations; Goals; Health; Health Personnel; Healthcare Systems; Heart failure; Heterogeneity; high risk; HIV; Home environment; Hospitalization; Hospitals; Hypertension; Immunocompromised Host; Individual; Infection; Infrastructure; instrument; Lead; Libraries; Longitudinal cohort study; Longitudinal Studies; male; Medical; Monitor; mortality; multiple data sources; North America; novel; Outcome; Participant; Patients; Peptidyl-Dipeptidase A; Persons; prospective; Race; receptor; Recovery; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; respiratory; Risk; Risk Estimate; Risk Factors; routine care; sample collection; SARS coronavirus; Severities; Severity of illness; sex; Societies; Symptoms; Telemedicine; Test Result; Testing; Time; tool; trend; United States; Virus; Work; young adult; ","NA-ACCORD COVID-19 Supplment","069918","","","","S1","14","138447","14205","152652",""
"9927563","UC7","AI","5","N","05/19/2020","05/01/2020","04/30/2021","","UC7AI094660","","RFA-AI-15-009","5UC7AI094660-10","NIAID:1020663\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","GALVESTON","UNITED STATES","","14","800771149","US","578406","UNIVERSITY OF TEXAS MED BR GALVESTON","TX","775555302","National Biocontainment Laboratories Operational Support ensures the availability of  maximum containment laboratories for research that will develop the next generation of  therapeutics, diagnostics and vaccines for infectious diseases that can pose a public  health risk. It also ensures that high containment labs are available in the event of a  public health or bioterrorism emergency. This support is essential due to the high cost  of building and maintaining laboratories that protect researchers, ensure the biosecurity  of dangerous pathogens, and safeguard the communities where these laboratories are  located.","10363552; ","LEDUC, JAMES W.;","","","","Advisory Committees; Animals; Basic Science; biodefense; biosecurity; Bioterrorism; Businesses; Centers of Research Excellence; Collaborations; Communicable Diseases; Communication; Communities; Community Relations; Containment; cost; Dangerousness; Diagnostic; Emergency response; Emergency Situation; Emerging Communicable Diseases; Ensure; Environmental Health; Equilibrium; Event; Funding; Goals; Individual; Infectious Diseases Research; Infrastructure; Institution; International; Laboratories; Laboratory Animals; Laboratory Personnel; Laboratory Research; Maintenance; Medical; Modernization; National Institute of Allergy and Infectious Disease; novel; novel therapeutics; Occupational activity of managing finances; operation; pathogen; Positioning Attribute; pre-clinical; product development; Program Development; programs; Public Health; public health emergency; Regulation; Research; Research Activity; research and development; research facility; Research Personnel; research study; Resources; Risk; Schedule; Secure; Services; Techniques; Technology; Texas; Time; Training; translational study; United States National Institutes of Health; Universities; Vaccines; Work; ","Administrative Core - Galveston National Laboratory BSL4 Operations","094660","ZAI1","Special Emphasis Panel ","8719","","10","661196","359467","","1020663"
"9914162","R01","AA","5","N","05/18/2020","05/01/2020","04/30/2021","273","R01AA025995","SCHOOLS OF ARTS AND SCIENCES","PA-16-160","5R01AA025995-03","NIAAA:542728\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM","","ATLANTA","UNITED STATES","PSYCHOLOGY","05","837322494","US","676604","GEORGIA STATE UNIVERSITY","GA","303023999","The proposed project will for the first time provide a comprehensive etiological model for SS-IPV perpetration that attends to both interactional and process-based factors that account for sexual minority stress effects at the individual- and couple-level of analysis. In doing so, this research will prioritize three perspectives highlighted by the Institute of Medicine (2011) report ? minority stress, social-ecology, and intersectionality ? while simultaneously addressing critical methodological weaknesses in the extant literature on partner violence within same-sex intimate relationships (SS-IPV). The intended outcome is for results derived from this project to provide the desperately needed evidence base to develop effective, culturally-informed IPV treatment and prevention efforts for same-sex couples.","8451745; ","PARROTT, DOMINIC ;","FREEMAN, ROBERT","05/01/2018","04/30/2023","Address; Alcohol consumption; alcohol effect; Alcoholic Intoxication; Anger; base; Behavior; cisgender; Couples; design; Development; diaries; Ecology; Etiology; evidence base; experience; experimental study; Failure; Female; Foundations; Gays; Goals; Gold; Health; Heterosexuals; high risk; Individual; innovation; Institute of Medicine (U.S.); intersectionality; Intervention; intimate partner violence; Knowledge; Laboratories; Lead; Lesbian; LGBT Health; Literature; male; Measurement; member; Methodology; Methods; Minority; Modeling; Outcome; Participant; partner violence; Pattern; Population; prevent; Prevention; Process; psychologic; Public Health; Recording of previous events; recruit; Reporting; Research; Research Design; resilience; Respondent; response; Risk; Risk Factors; Same-sex; same-sex partnership; Sampling; Sex Differences; sexual minority; sobriety; social; Social Identification; Specific qualifier value; Stress; Testing; therapy design; therapy development; Time; Work; ","Proximal Effects of Alcohol on Same-Sex Intimate Partner Violence","025995","ARM","Addiction Risks and Mechanisms Study Section ","","","03","365532","177196","542728",""
"10113030","U10","CA","3","N","05/21/2020","03/01/2020","02/28/2021","395","U10CA180886","","RFA-CA-17-056","3U10CA180886-07S1","NCI:3105783\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","PHILADELPHIA","UNITED STATES","","03","073757627","US","1499101","CHILDREN'S HOSP OF PHILADELPHIA","PA","191462305","PROJECT NARRATIVE The Children's Oncology Group (COG) is the world's largest organization devoted exclusively to childhood and adolescent cancer research. Over 220 leading children's hospitals, universities, and cancer centers across US, Canada and other countries participate in COG research, which is focused on developing better treatments that can improve the cure rate and outcome for all children with cancer.","6117766 (contact); 10871228; ","APLENC, RICHARD  (contact); HAWKINS, DOUGLAS S;","MOONEY, MARGARET M","04/11/2014","02/28/2025","1 year old; Acute; Acute Myelocytic Leukemia; Adolescent; Advanced Development; anticancer research; Australia; Brain Stem Glioma; Canada; Cancer Center; cancer diagnosis; Cancer Patient; Cancer Survivor; cancer therapy; Caring; Cause of Death; chemotherapy; Child; Child Support; Childhood; childhood cancer survivor; Childhood Leukemia; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Collection; Communities; Complication; Country; design; Diagnosis; Disease; Dose; Enrollment; Ensure; experience; Family; Foundations; Functional disorder; Generations; Goals; health related quality of life; high risk; Hormonal; Immunotherapy; improved; improved outcome; Infrastructure; innovation; Institution; Interdisciplinary Study; Knowledge; Laboratories; Late Effects; Lead; Malignant Childhood Neoplasm; Malignant Neoplasms; member; Methods; Mission; Molecular; Morbidity - disease rate; multidisciplinary; National Cancer Institute; National Clinical Trials Network; Neuroblastoma; New Zealand; novel therapeutic intervention; operation; Organ; organizational structure; Outcome; outcome forecast; Patients; Pediatric Hospitals; Pediatric Oncology Group; Pharmaceutical Preparations; Population Heterogeneity; Population Research; Positioning Attribute; Quality of life; Rare Diseases; reproductive; Research; Research Personnel; Scientist; Second Primary Cancers; Site; small molecule; success; Survival Rate; Survivors; survivorship; Tissues; Translational Research; translational study; United States; Universities; Work; ","COG NCTN Network Group Operations Center","180886","ZCA1","Special Emphasis Panel ","","S1","07","2728364","377419","3105783",""
"9918338","R01","DK","5","N","05/21/2020","05/01/2020","04/30/2021","847","R01DK112042","","PA-16-160","5R01DK112042-04","NIDDK:432346\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","SAN DIEGO","UNITED STATES","","52","933863508","US","2908201","VETERANS MEDICAL RESEARCH FDN/SAN DIEGO","CA","921610002","PROJECT NARRATIVE SGLT2 blockers and GLP-1 receptor agonists are two new classes of anti-diabetic drugs that lower blood glucose by different mechanisms, are prescribed to millions of patients, and have off-target effects on kidney function that are only partly understood. The proposed research will investigate the effects of these drugs, and of dietary salt, on several nuances of kidney function in rats and mice with diabetes. The goal is to leverage readily available drugs and diets to reduce physical and metabolic stress on the hyper-functioning diabetic kidney, thereby protecting it from damage.","2251950 (contact); 8470371; ","THOMSON, SCOTT C. (contact); VALLON, VOLKER ;","MARIC-BILKAN, CHRISTINE","07/01/2017","04/30/2022","5'-AMP-activated protein kinase; Address; Affect; Agonist; Antidiabetic Drugs; Blood Glucose; Blood Pressure; Caring; Clinical; Clinical Trials; Consumption; Coupling; Diabetes Mellitus; diabetic; diabetic patient; Diet; dietary salt; Electron Transport; Elements; Equilibrium; exenatide; experimental study; Glomerular Capillary; glomerular filtration; GLP-I receptor; Gluconeogenesis; Glucose; Goals; Growth; hemodynamics; Homeostasis; Hypersensitivity; Hypertension; Hypoxia; in vivo; inhibitor/antagonist; insight; Kidney; kidney fibrosis; Knowledge; Logic; Measures; Mediating; Medical; Metabolic; Metabolic stress; Metabolism; Metformin; Methods; Micropuncture; mitochondrial dysfunction; Modeling; Mus; Nephrons; Organ; Outcome; Oxygen; Oxygen Consumption; Patients; Pharmaceutical Preparations; Physiology; pressure; protective effect; Public Health; Rattus; Receptor Activation; Recommendation; Renal Blood Flow; Renal function; renal hypoxia; Research; response; Role; saluretic; Series; Systems Theory; Testing; Time; Tissues; treatment effect; Tubular formation; Work; ","Glomerular and Tubular Function in the Diabetic Kidney","112042","KMBD","Kidney Molecular Biology and Genitourinary Organ Development ","","","04","302340","130006","432346",""
"10042732","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI154208","SCHOOLS OF MEDICINE","PA-19-053","1R21AI154208-01","NIAID:251250\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","WORCESTER","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","603847393","US","850903","UNIV OF MASSACHUSETTS MED SCH WORCESTER","MA","016550002","Leishmaniasis is a disease endemic to tropical and subtropical developing countries caused by Leishmania parasites, with nearly 1 million new cases annually. No preventive vaccines are available and standard treatments for leishmaniasis use drugs with variable efficacy and high toxicity. In order to develop a new generation of more targeted therapies, a deeper understanding of the virulences strategies used by this parasite are necessary, and to address this need, this application is focused on a cellular post-translation modification, known as SUMOylation, and its role in limiting Leishmania infection of white blood cells.","11711392; 1952761 (contact); ","OKUDA, KENDI ; SILVERMAN, NEAL  (contact);","PESCE, JOHN T","05/22/2020","04/30/2022","Address; Adult; Affect; Animals; base; Biogenesis; Catalogs; CD36 gene; Cell Line; Cells; Cessation of life; Cholesterol; Developing Countries; Development; Disease; Drosophila genus; Drug resistance; Drug usage; Endemic Diseases; enhancing factor; Family; Gene Expression; Generations; Genes; Genetic Screening; genome wide screen; genome-wide; Growth; Hela Cells; Human; Human body; in vivo; Infection; Insect Vectors; Integration Host Factors; Interleukin-12; Invaded; knock-down; Leishmania; Leishmaniasis; Leukocytes; macrophage; member; Modeling; Modification; Molecular; mouse model; Mus; novel; novel therapeutic intervention; overexpression; Parasites; Parasitic infection; Pathology; Patients; Phagocytes; Phagosomes; Phlebotominae; Post-Translational Protein Processing; Prevalence; Preventive vaccine; Process; programs; Proliferating; protein function; Protein Inhibition; Proteins; Research; resistant strain; RNA interference screen; Role; scavenger receptor; Skin; standard care; Symptoms; targeted treatment; Toxic effect; trafficking; Translations; Ubiquitin; Vacuole; vector; Virulence; Virulence Factors; ","Leishmania amazonensis sabotages host SUMOylation: a novel virulence mechanism for macrophage invasion","154208","PTHE","Pathogenic Eukaryotes Study Section ","","","01","150000","101250","251250",""
"9974305","R01","CA","1","N","05/18/2020","05/18/2020","04/30/2021","396","R01CA241728","SCHOOLS OF ARTS AND SCIENCES","PA-19-056","1R01CA241728-01A1","NCI:593012\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","LA JOLLA","UNITED STATES","ENGINEERING (ALL TYPES)","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","Project Narrative We will develop synthetically engineered bacterial cells effective in treating a broad range of cancers using species known to selectively colonize solid tumors. These tumor targeting organisms will be engineered to deliver a variety of anti-tumor therapeutics using a novel lysis mechanism our research group developed which expands the spectrum of compounds feasible for bacterial cancer treatment. After construction our cells will undergo rigorous testing in biologically relevant, in vitro preclinical cancer models featuring human tumor organoids allowing us to identify the most promising therapy strains for subsequent testing in mouse models of cancer.","7622867 (contact); 8454082; ","HASTY, JEFF M (contact); KNIGHT, ROB ;","DASCHNER, PHILLIP J","05/18/2020","04/30/2024","Acoustics; Address; American; Animal Model; Animal Testing; Animals; Antibiotics; Apoptotic; B lymphoid malignancy; Bacteria; base; beneficial microorganism; Biological; Biological Assay; cancer cell; Cancer cell line; Cancer Etiology; Cancer Model; cancer therapy; cancer type; Cells; Cessation of life; chemotherapy; chimeric antigen receptor T cells; Clinical Trials; Cloning; Coculture Techniques; Colonoscopy; Colorectal; Colorectal Cancer; colorectal cancer treatment; Colorectal Neoplasms; Consumption; cost; cost effective; CRISPR/Cas technology; Cytolysis; Data; Development; Disease; effective therapy; efficacy testing; Engineering; Environment; Enzymes; Escherichia coli; Evaluation; experimental study; Fingerprint; Genetic; Genetic Engineering; genetically modified cells; Growth; Home environment; Human; Human body; human disease; Human Microbiome; human tissue; Immune response; In Situ; In Situ Hybridization; In Vitro; in vitro Assay; in vivo; in vivo imaging; Lead; Libraries; Liquid substance; Location; Malignant Neoplasms; Mammalian Cell; Metastatic Neoplasm to the Liver; microbiome; microfluidic technology; Microfluidics; Modeling; Modification; Molecular; mouse model; Mucous Membrane; Mus; Natural Products; Nature; novel; Oral; Organism; Organoids; Pathogenicity; Pathologic; peptide drug; Peptides; Plants; Population; Population Density; pre-clinical; Pre-Clinical Model; Prevalence; Probiotics; Property; prospective; Research; Sampling; Series; Societies; Solid; Solid Neoplasm; synthetic biology; System; Testing; Therapeutic; Therapeutic Agents; therapeutic candidate; therapeutic enzyme; therapeutic evaluation; therapeutic protein; Therapeutic Uses; therapy development; Time; Tissue Sample; Tissues; tool; Toxin; Treatment Efficacy; tumor; Tumor Burden; tumor microbiome; tumor specificity; Tumor Tissue; Work; ","A microbiome-informed platform for the development and testing of bacterial therapies for colorectal cancer","241728","CPSS","Cancer Prevention Study Section ","","A1","01","406622","186390","593012",""
"9922978","T32","HL","5","N","05/21/2020","05/01/2020","04/30/2021","839","T32HL007974","SCHOOLS OF MEDICINE","PA-14-015","5T32HL007974-19","NHLBI:313417\","TRAINING, INSTITUTIONAL","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NEW HAVEN","UNITED STATES","PATHOLOGY","03","043207562","US","9420201","YALE UNIVERSITY","CT","065208327","PUBLIC HEALTH RELEVANCE The newly emerging areas of stem cell biology, cell based therapies, gene therapy, cellular immunology, recombinant cytokines, and improving the safety and efficacy of transfused blood components have potential for the improvement of transfusion practices and the management of hematologic diseases. Thus, it is critical to train the next generation of investigators who can conduct basic, translational, and clinical research in Immunohematology and Transfusion Medicine. This proposed program renewal, with a 15 year successful history, aims to accomplish these goals.","1859405; 1864652 (contact); ","KRAUSE, DIANE S; SMITH, BRIAN RICHARD (contact);","MONDORO, TRACI","08/01/2001","04/30/2022","immunohematology; Research Training; transfusion medicine; ","Immunohematology/Transfusion Medicine Research Training","007974","NITM","NHLBI Institutional Training Mechanism Review Committee ","","","19","469224","33698","313417",""
"10057300","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI148869","EARTH SCIENCES/RESOURCES","PA-19-020","1R21AI148869-01A1","NIAID:233625\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","KINGSTON","UNITED STATES","BIOCHEMISTRY","02","144017188","US","6969201","UNIVERSITY OF RHODE ISLAND","RI","028810811","PROJECT NARRATIVE An improved understanding of the quality of Abs elicited during flavivirus infection is necessary as it is becoming clear that antibody function beyond neutralization is important. For this proposal, we will establish novel assays to assess antibody dependent cell mediated cytotoxicity (ADCC) activity of antibodies in dengue and zika immune individuals. Using samples from prospective cohorts we will correlate ADCC antibody functions with clinical outcome which will be important to guide the development of an effective flavivirus vaccine.","2044234; ","MATHEW, ANUJA ;","FERGUSON, STACY E","05/22/2020","04/30/2022","Antibodies; Antibody Specificity; Antibody titer measurement; antibody-dependent cell cytotoxicity; Antigens; Biological Assay; Cell Line; Cells; Cellular Assay; Cessation of life; Child; Clinical; cohort; Cohort Studies; Cytolysis; Data; Dengue; Dengue Infection; Dengue Vaccine; Dengue Virus; density; Development; Disease; Disease Outcome; Effector Cell; env Gene Products; Flavivirus; Flavivirus Infections; Flow Cytometry; Goals; Image Cytometry; Immune; Immune Sera; Immunity; immunogenic; Immunoglobulin Constant Region; Immunoglobulin G; improved; in vitro Assay; in vivo; Individual; Infection; Measures; Mediating; Membrane Proteins; Monoclonal Antibodies; mosquito-borne; Natural Killer Cells; neutralizing antibody; next generation; NK Cell Activation; novel; Outcome; pathogenic virus; Peripheral Blood Mononuclear Cell; Phase; Phase III Clinical Trials; Pilot Projects; Play; prospective; Prospective cohort; Prospective Studies; Proteins; Refractory; Reporting; Reproducibility; Role; Sampling; Serotyping; Source; Surface; Thailand; vaccine development; vaccine trial; Vaccines; Viral; Viremia; Virus Diseases; ZIKA; Zika Virus; Zika virus vaccine; ","Elimination of flavivirus infected target cells by ADCC","148869","VIRB","Virology - B Study Section ","","A1","01","150000","83625","233625",""
"9824587","R21","MH","5","N","05/18/2020","11/01/2019","10/31/2020","242","R21MH118594","","PAR-17-152","5R21MH118594-02","NIMH:221250\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BOSTON","UNITED STATES","","07","076593722","US","1504801","BOSTON CHILDREN'S HOSPITAL","MA","021155724","Narrative The goal of this proposal is to develop new methods to characterize tRNA modifications in stem cells, neuronal cells, and brain tissue and will facilitate investigation of the role of tRNA methylation in mental illnesses.","8793150; ","GREGORY, RICHARD I.;","BEER, REBECCA LYNN","12/01/2018","10/31/2020","Address; Adult; Awareness; Brain; Brain Diseases; brain malformation; brain tissue; Candidate Disease Gene; Cell model; Cell physiology; Cells; Cognition; Complex; Corpus Callosum; CRISPR/Cas technology; Development; dosage; Down Syndrome; Dwarfism; embryonic stem cell; Encephalopathies; Enzymes; epitranscriptome; Exhibits; experimental study; Face; Funding; Funding Mechanisms; Gene Cluster; Genes; Goals; Heat Stress Disorders; Hippocampus (Brain); Human; Human Chromosomes; Individual; induced pluripotent stem cell; Intellectual functioning disability; Investigation; Knockout Mice; Learning; Link; Mammals; Maps; Mediating; Memory; Mental disorders; Mental Retardation; Messenger RNA; Methods; Methylation; methylome; Modeling; Modification; Molecular; Monitor; Monosomy; Mus; Mutation; National Institute of Drug Abuse; National Institute of Mental Health; Nerve Degeneration; neurogenesis; Neuronal Differentiation; Neurons; Northern Blotting; Nucleotides; overexpression; Patients; Phenotype; Physiological; relating to nervous system; Resolution; Ribosomes; RNA; Role; Sampling; Seizures; stem cell differentiation; Stem cells; stoichiometry; System; Technology; Testing; tool; Transfer RNA; Translations; Trisomy; tRNA Methyltransferases; Work; Yeasts; ","Methods to map the m7G tRNA methylome","118594","MNG","Molecular Neurogenetics Study Section ","","","02","125000","96250","221250",""
"9930459","P01","GM","5","N","05/20/2020","05/01/2020","04/30/2021","","P01GM099134","","PAR-13-280","5P01GM099134-09","NIGMS:423739\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","8752436; ","PLATH, KATHRIN ;","","","","B-Lymphocytes; base; Binding; Biological Assay; c-myc Genes; cell type; Cells; Chromatin; Chromatin Structure; Collaborations; combinatorial; Complex; CpG Islands; demethylation; Development; Disease; DNA; DNA Methylation; DNA Sequence; Enhancers; Event; experimental study; Fibroblasts; Gene Activation; Genetic; Genetic Enhancer Element; Genetic Transcription; Genetic Variation; Genomics; Goals; Heterochromatin; Human; induced pluripotent stem cell; insight; keratinocyte; knock-down; Lead; Link; Location; Mediating; Methylation; Modeling; Molecular; Mus; nerve stem cell; Neurons; novel strategies; Pathway interactions; pluripotency; Positioning Attribute; Post-Transcriptional Regulation; Process; programs; Proteomics; Site; Somatic Cell; Structure; Testing; Time; transcription factor; transcriptome; Work; X Inactivation; ","Mechanisms of transcription factor-guided enhancer reorganization and heterochromatin disassembly during reprogramming to iPSCs","099134","ZRG1","Special Emphasis Panel ","6048","","09","275155","148584","","423739"
"10052401","R01","AI","1","N","05/18/2020","05/18/2020","04/30/2021","855","R01AI148417","SCHOOLS OF MEDICINE","PA-19-056","1R01AI148417-01A1","NIAID:393750\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LA JOLLA","UNITED STATES","PHARMACOLOGY","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","PROJECT NARRATIVE Community-associated (CA) MRSA is a major health concern worldwide that causes significant morbidly and mortality in humans. This work will fill a critical gap in knowledge pertaining to how the peptidome contributes to CA-MRSA disease etiologies. The information gained from this work has the potential to discover new mechanisms of host-pathogen interactions and can lead to the rational design of anti-virulence based therapies. !","9645429; ","GONZALEZ, DAVID J;","HUNTLEY, CLAYTON C","05/18/2020","04/30/2025","Address; Area; Bacteria; base; Binding; Biochemical; Biological Assay; Biological Process; Biology; cell type; Cells; Communities; Complex; Cytolysins; Data; design; Development; Discipline; Disease; Environment; Epithelial; Epithelium; Etiology; Genome; Genomics; Genus staphylococcus; Health; Host Defense; Human; human pathogen; In Vitro; in vivo; Infection; Infectious Skin Diseases; innovation; Keratin; Knowledge; Lead; Libraries; Lipoproteins; Mass Spectrum Analysis; methicillin resistant Staphylococcus aureus; Microbiology; Modeling; Molecular; mortality; multiple omics; Mus; mutant; novel; novel therapeutics; pathogen; Pathogenesis; Pathogenicity; Pathway interactions; Penetration; Peptides; Phenols; Play; Process; prohibitin; Proteins; Proteome; Proteomics; Publishing; PubMed; Regulator Genes; Research; Role; Serum; skin lesion; Staphylococcal Infections; Staphylococcus aureus; Structure; synthetic peptide; System; Targeted Toxins; Testing; Tissues; Transcript; Virulence; Virulence Factors; Work; ","Contribution of the peptidome to CA-MRSA virulence","148417","BACP","Bacterial Pathogenesis Study Section ","","A1","01","250000","143750","393750",""
"9954586","R03","HD","1","N","05/19/2020","05/19/2020","04/30/2021","865","R03HD101767","","PA-18-481","1R03HD101767-01","NICHD:76451\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","STONY BROOK","UNITED STATES","","01","804878247","US","5992612","STATE UNIVERSITY NEW YORK STONY BROOK","NY","117943362","PROJECT NARRATIVE Neurodevelopmental disorders including autism spectrum disorder, intellectual disability, and schizophrenia have devasting impacts on families. The etiology of neurodevelopmental disorders is poorly defined, limiting treatment alternatives. The GluN2B subunit of the NMDA receptor is a critical element in normal brain development and when dysfunctional leads to numerous neurodevelopmental disorders. We are studying how the GluN2B subunit contributes to brain development with the long-term goal of developing novel treatments.","7510683 (contact); 1931960; ","SIROTKIN, HOWARD I (contact); WOLLMUTH, LONNIE P;","PARISI, MELISSA","05/19/2020","04/30/2022","Affect; alternative treatment; Animal Model; autism spectrum disorder; base; Behavior; Behavioral; Biological Models; Birth; Brain; Cells; Complex; desensitization; Development; Developmental Delay Disorders; Disease; Drug Screening; Electrophysiology (science); Elements; Etiology; experimental study; Family; Fertilization; Foundations; Functional disorder; Genes; Glutamate Receptor; Goals; habituation; Human; Intellectual functioning disability; Ion Channel Gating; Kinetics; Knock-out; Learning; Lesion; Ligands; Link; loss of function; Mediating; Memory; Missense Mutation; Modeling; Motor Activity; Movement; Mus; N-Methyl-D-Aspartate Receptors; Neonatal; nervous system development; neural circuit; Neurodevelopmental Disorder; neurotransmission; NMDA receptor A1; Nonsense Mutation; novel; novel therapeutics; patch clamp; Pathway interactions; Perinatal; Permeability; Pharmacology; Physiology; preference; prepulse inhibition; Process; Property; receptor; relating to nervous system; Role; Schizophrenia; small molecule; social; Structure; Synapses; Synaptic plasticity; Synaptic Transmission; synaptogenesis; System; Testing; transmission process; Variant; Zebrafish; ","GluN2B Associated Neurodevelopmental Disorders","101767","CHHD","National Institute of Child Health and Human Development Initial Review Group ","","","01","50000","26451","76451",""
"9881354","K23","MH","5","N","05/18/2020","03/01/2020","02/28/2021","242","K23MH117280","SCHOOLS OF ARTS AND SCIENCES","PA-18-375","5K23MH117280-02","NIMH:176819\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","MIAMI","UNITED STATES","PSYCHOLOGY","26","071298814","US","513809","FLORIDA INTERNATIONAL UNIVERSITY","FL","331990001","Project Narrative  Attention-deficit/hyperactivity disorder (ADHD) has often been viewed as a cognitive disorder, work by the applicant and others has established the need to integrate emotional functioning into conceptualization of the disorder and clinical care. The current project seeks to use a multimethod approach to examine the individual and combined effects of emotional systems across the domains of negative emotion reactivity, positive emotion reactivity, and effortful emotion regulation in ADHD. It is anticipated that the results will help to improve both precision in diagnosis and in the development of new treatments.","10584675; ","MUSSER, ERICA D;","BECHTHOLT, ANITA J","03/01/2019","02/28/2023","Address; Affect; aged; Amygdaloid structure; Analysis of Covariance; Arousal; Attention; Attention deficit hyperactivity disorder; Autonomic nervous system; Basic Science; Behavior; Behavioral; Child; Child Mental Health; Childhood; Clinical; clinical care; clinical Diagnosis; Cognition Disorders; cognitive reappraisal; computerized data processing; data acquisition; Data Analyses; design; Development; Diagnosis; Disease; disease classification; Electrocardiogram; emotion dysregulation; emotion regulation; Emotional; Emotions; Ethics; Etiology; executive function; Functional disorder; Functional Magnetic Resonance Imaging; Future; Goals; Heterogeneity; improved; indexing; Individual; Insula of Reil; Intervention; Link; Measures; Mental Health; Methods; Modeling; Nervous System Physiology; Neuraxis; neurobiological mechanism; neuroimaging; Neurosecretory Systems; novel; Nucleus Accumbens; Parasympathetic Nervous System; Participant; Pathway interactions; Patient Self-Report; personalized approach; Physiological; positive emotional state; Prevalence; Process; programs; Psychiatry; Psychology; Psychophysiology; Regulation; Research; Research Activity; Respiration; respiratory; response; Rewards; Role; Route; Sinus Arrhythmia; skill acquisition; Statistical Data Interpretation; statistics; System; theories; Time; Training; Training Activity; Translational Research; Unconscious State; Ventral Striatum; Work; Youth; ","Emotional Systems in Attention-Deficit/Hyperactivity Disorder","117280","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","","02","163721","13098","176819",""
"9903392","R01","GM","5","N","05/20/2020","05/01/2020","04/30/2021","859","R01GM129157","SCHOOLS OF MEDICINE","PA-16-160","5R01GM129157-04","NIGMS:324000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","NEW YORK","UNITED STATES","INTERNAL MEDICINE/MEDICINE","13","621889815","US","1833205","COLUMBIA UNIVERSITY HEALTH SCIENCES","NY","100320049","RELEVANCE Pluripotency spans a spectrum encompassing two distinct pluripotent states, naive and primed, which are represented by mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs), respectively, the two in vitro counterparts of inner cell mass of pre-implantation blastocyst and post-implantation epiblast of developing mouse embryos. Elucidation of molecular mechanism by which the novel pluripotency factor Zfp281 regulates pluripotent state transitions with both cellular and mouse models will provide fundamental knowledge on finely coordinated transcriptional and epigenetic control of mammalian cell fate changes and embryonic development, dysregulation of which is often associated with disease and cancer.","10357639; ","WANG, JIANLONG ;","GIBBS, KENNETH D","08/06/2018","04/30/2022","Alleles; blastocyst; Cell model; cofactor; Development; differential expression; Disease; DNA; DNMT3a; Embryo; Embryonic Development; embryonic stem cell; Enzymes; Epiblast; Epigenetic Process; epigenome; Event; Genes; Genetic Transcription; Genomics; Goals; Human; human embryonic stem cell; implantation; In Vitro; in vivo; induced pluripotent stem cell; Inner Cell Mass; insight; Knock-out; Knockout Mice; Knowledge; Maintenance; Malignant Neoplasms; Mammalian Cell; Methylation; Mixed Function Oxygenases; Modeling; Molecular; mouse model; Mouse Strains; Mus; natural Blastocyst Implantation; Nodal; novel; Play; pluripotency; Pluripotent Stem Cells; preimplantation; Proteins; Proteomics; recruit; Role; screening; Signal Transduction; Somatic Cell; Stem Cell Development; Stem cells; System; Testing; Tissues; Transcription Coactivator; transcription factor; Transcription Process; Work; ","Transcriptional and Epigenetic Control of Pluripotency and Development by Zfp281","129157","DEV1","Development - 1 Study Section ","","","04","200000","124000","324000",""
"9922305","P20","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P20GM103440","","PAR-14-233","5P20GM103440-18","NIGMS:882083\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","RENO","UNITED STATES","","02","146515460","US","829903","UNIVERSITY OF NEVADA RENO","NV","89557","Developmental Research Project and Pilot Grant Programs ? Narrative Biomedical research opportunities for students and faculty at Nevada universities, colleges, and community colleges are limited by a lack of research infrastructure and funding opportunities, which is unfortunate because many faculty at these institutions are Ph.D. trained with promising research programs and an interest in advancing their research programs and in providing authentic research experiences for students. Our DRP and PG program will increase the research activities at UNR and UNLV and develop researchers and their research projects at Outreach Institutions by providing research funding, experienced mentorship, and resources through bioinformatics and other cores to generate publications, grant funding, and/or new research opportunities for undergraduate students.","8897571; ","BAKER, JONATHAN E.;","","","","Address; Adherence; Applications Grants; Award; base; Bioinformatics; bioinformatics tool; Biomedical Research; Biometry; career development; cell growth; Centers of Research Excellence; Collaborations; college; community college; Data; Development; Differentiation and Growth; Doctor of Philosophy; Educational Curriculum; Educational workshop; experience; Extramural Activities; Faculty; Feedback; Funding; Funding Opportunities; Future; Grant; Institution; inter-institutional; interest; meetings; Mentors; Mentorship; Monitor; Nevada; Outcome; Outcomes Research; outreach; Phase; Program Research Project Grants; programs; Publications; Publishing; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Services; Students; Supervision; Teacher Professional Development; Training; undergraduate student; United States National Institutes of Health; Universities; Writing; ","Developmental Research Project Program","103440","ZGM1","Special Emphasis Panel ","7785","","18","800026","82057","","882083"
"9928425","R01","EB","5","N","05/20/2020","05/01/2020","04/30/2021","286","R01EB026890","BIOMED ENGR/COL ENGR/ENGR STA","PAR-16-044","5R01EB026890-03","NIBIB:495643\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","SEATTLE","UNITED STATES","ENGINEERING (ALL TYPES)","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","Project Narrative This proposal describes a nanotechnology-based approach that combines the gene and immune therapies to treat breast cancer by simultaneously inhibiting tumor growth and activating T cells for tumor tissue destruction. Our approach involves the development of a non-viral nanovector that is able to overcome extra- and intra-cellular barriers and specifically deliver genes and induce gene expression only in breast cancer cells. This synergetic strategy aims to address the limitations of current breast cancer therapies, and if successful, could substantially improve the treatment outcome and minimize deleterious side effects.","6617271; ","ZHANG, MIQIN ;","RAMPULLA, DAVID","08/01/2018","04/30/2022","3-Dimensional; acquired drug resistance; Address; Affect; base; biodegradable polymer; Biodistribution; Biological; Blood Cells; Breast Cancer Cell; Breast Cancer Patient; Breast Cancer therapy; cancer cell; Cancer Etiology; cancer therapy; Cell Proliferation; Cessation of life; chemotherapy; Chitosan; combat; Complex; Culture Media; Cytomegalovirus; cytotoxicity; design; Development; Disease; DNA; Drug Delivery Systems; Drug Kinetics; extracellular; Fluorescence; Gene Expression; Gene Proteins; gene therapy; Genes; Half-Life; Image; Immune; Immunotherapy; improved; In Vitro; in vivo; Interferon Type II; iron oxide; iron oxide nanoparticle; Ligands; Magnetic Resonance Imaging; malignant breast neoplasm; Malignant Neoplasms; Molecular Weight; Monitor; Mus; Nanotechnology; nanotheranostics; nanovector; neoplastic cell; Operative Surgical Procedures; plasmid DNA; Plasmids; Polyethylene Glycols; Polymers; promoter; Proteins; Radiation therapy; Research; selective expression; Series; Serum; side effect; Specificity; superparamagnetism; SYK gene; systemic toxicity; T-Lymphocyte; Therapeutic; therapeutic gene; therapy resistant; Time; Tissues; Toxic effect; Transfection; Transgenic Mice; Treatment Efficacy; Treatment outcome; Treatment-related toxicity; tumor; tumor eradication; tumor growth; Tumor Tissue; United States; vector; Woman; Xenograft procedure; ","Iron oxide nanotheranostics for breast cancer","026890","ZRG1","Special Emphasis Panel ","","","03","317232","178411","495643",""
"9918765","I01","VA","5","N","05/21/2020","02/01/2020","01/31/2021","999","I01RX002300","","RFA-RX-16-003","5I01RX002300-04","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","SAN FRANCISCO","UNITED STATES","","12","078763885","US","481016","VETERANS AFFAIRS MED CTR SAN FRANCISCO","CA","941211545","One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with mild TBI and comorbid conditions. When completed, these studies will inform us whether training core attentional self-regulatory control functions via personally-relevant activities will be effective in improving daily life for Veterans with mild TBI and comorbid conditions. The study design will provide a test not only of potential benefits for real life functioning, but also determine to what extent these benefits are related to actual changes in cognitive/behavioral performance and brain networks corresponding to these functions. This project will provide a foundation for future studies to investigate the neural mechanisms that support improvements of cognition and behavior in mTBI.","1925232; ","MUKHERJEE, PRATIK ;","","02/01/2017","09/30/2021","Address; Affect; Amygdaloid structure; Area; Attention; attentional control; base; Base of the Brain; Behavior; Behavioral; Brain; Brain Injuries; Chronic; Cognition; Cognitive; cognitive control; cognitive performance; cognitive training; combat; comorbidity; Complex; daily functioning; Data; design; Diffusion Magnetic Resonance Imaging; Effectiveness; emotion regulation; Emotional; Emotions; executive function; extrastriate visual cortex; Foundations; Freedom; Functional Magnetic Resonance Imaging; Future; Goals; Image; improved; improved functioning; Individual; individual variation; Informal Social Control; information processing; Intervention; Intervention Studies; Learning; Life; Long-Term Effects; Magnetic Resonance Imaging; Measures; Memory; mild traumatic brain injury; mindfulness; Neural Pathways; Neurocognitive; neuroimaging; neuromechanism; Neuronal Plasticity; Neuropsychology; neuroregulation; operation; Participant; Pathway interactions; Patient Self-Report; Pattern; Performance; Pharmacological Treatment; predictive marker; Prefrontal Cortex; Problem Solving; Process; Quality of life; Randomized; Recording of previous events; Regimen; Regulation; rehabilitation paradigm; Rehabilitation therapy; relating to nervous system; Reporting; Research Design; Residual state; response; Rest; Short-Term Memory; Structure; Task Performances; Testing; Training; Training Programs; Transcranial magnetic stimulation; treatment as usual; Veterans; white matter; ","Multi-level assessment and rehabilitation of combat mild traumatic brain injury","002300","RRD1","Brain Health & Injury ","","","04","","","",""
"9918113","P30","ES","1","N","05/21/2020","05/15/2020","03/31/2021","","P30ES030284","","RFA-ES-18-003","1P30ES030284-01A1","NIEHS:214257\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","10734663; ","PADULA, AMY MICHELLE;","","05/22/2020","03/31/2025","Affect; Air; Analytical Chemistry; Animals; Area; Back; base; Basic Science; Bioinformatics; Biological; biological research; Businesses; California; Censuses; Chemical Exposure; Chemicals; Child; Chronic Disease; Clinical; Clinical Medicine; Clinical Research; Clinical Sciences; Communication; Communities; Commuting; Complex; Consult; Consultations; Core Facility; Data; Data Analyses; data integration; data resource; Databases; Development; Developmental Biology; Diabetes Mellitus; digital; Discipline; Discipline of obstetrics; Ecology; Environment; environmental chemical; environmental chemical exposure; environmental chemistry; Environmental Exposure; Environmental Health; Epidemiology; epidemiology study; Evaluation; Experimental Models; exposure pathway; Exposure to; farmers markets; food environment; gene environment interaction; Geographic Information Systems; geographic population; Geography; Goals; Green space; Gynecology; Health; health data; Health Professional; health science research; Health Sciences; Human; improved; indexing; insight; instrument; Integrative Medicine; interdisciplinary approach; Investigation; Leadership; Libraries; literacy; Malignant Neoplasms; Maps; Measures; medical specialties; member; Meta-Analysis; Methodology; Methods; next generation; novel; Outcome; Participant; Pathway interactions; Patients; Pattern; Pesticides; Planet Earth; Pollution; Population; population health; Population Research; programs; psychosocial; Psychosocial Stress; Public Health; Questionnaires; Reporting; reproductive; Reproductive Biology; Reproductive Health; Research; Research Design; Research Personnel; Resources; Restaurants; Role; San Francisco; Science; Scientist; Services; social; Societies; socioeconomics; Specialist; statistics; stressor; Study models; systematic review; Testing; tool; Training; Translational Research; Translations; Universities; Vulnerable Populations; Water; ","Integrative Health Sciences Facility Core","030284","EHS","Environmental Health Sciences Review Committee ","7073","A1","01","133221","81036","","214257"
"10001705","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI149730","SCHOOLS OF PUBLIC HEALTH","PA-19-053","1R21AI149730-01A1","NIAID:204036\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","TAMPA","UNITED STATES","OTHER HEALTH PROFESSIONS","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","Project Narrative Antimalarial drug treatment failures with the current frontline artemisinin-based combination therapies (ACTs) is an emerging crisis for malaria control and elimination. Our goal for this project is to explore Ivermectin mass drug administration (MDA) in combination with other antimalarial drugs as a malaria transmission control tool to kill the mosquito vector and aid in malaria elimination.","1888906; ","ADAMS, JOHN H;","O'NEIL, MICHAEL T","05/22/2020","04/30/2022","Address; Affect; Antimalarials; Apoptosis; Artemisinins; assay development; base; Biological Assay; Biological Availability; Blood; cell motility; Cell physiology; Cells; Chemoprophylaxis; Clinical Treatment; Clinical Trials; combat; Combined Modality Therapy; Cryopreservation; Culicidae; CYP3A4 gene; Cytology; Data; design; Development; Drug Combinations; Drug Interactions; Drug Kinetics; Drug resistance; Evaluation; Exposure to; Future; Goals; Hepatocyte; Human; In Vitro; in vivo; Individual; Infection; inhibitor/antagonist; Ivermectin; Liver; Malaria; malaria transmission; Metabolic; Metabolism; Methods; Modeling; Molecular; mouse model; novel; Parasite resistance; Parasites; Participant; Pharmaceutical Preparations; Pharmacodynamics; Pharmacotherapy; Phenotype; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium vivax; Population; Primaquine; Property; Resistance; Sporozoites; tool; Translating; transmission process; Treatment Failure; trend; vector mosquito; ","Evaluation of ivermectin as an antimalarial therapy against P. falciparum liver stage","149730","ZRG1","Special Emphasis Panel ","","A1","01","156282","47754","204036",""
"9908686","R43","HL","1","N","05/20/2020","05/20/2020","04/30/2021","838","R43HL147747","","PA-18-574","1R43HL147747-01A1","NHLBI:221408\","SBIR-STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CLIFTON PARK","UNITED STATES","","20","010926207","US","4014501","KITWARE, INC.","NY","120653104","PROJECT NARRATIVE Self-expanding transcatheter pulmonary valve replacement for patients with pulmonary insufficiency and native (non-conduit) right ventricular outflow tracts has become a reality, but determination of patient eligability and optimal device selection remains extremely difficult. We propose to develop an image based computer modeling tool to guide efficient and accurate selection of the best device for an individual patient. The proposed tool will simulate device and vessel mechanics, their interaction, and present cardiologists with key metrics to aid the decision-making process.","14226133; ","ARIKATLA, VENKATA SREEKANTH;","FESSEL, JOSHUA P","05/20/2020","04/30/2021","3-Dimensional; 3D Print; Address; Adult; base; Cardiac Surgery procedures; Cardiology; Catheters; Clinical; clinical decision-making; computational platform; Computer Assisted; Computer Models; Computers; congenital heart disorder; cost; Decision Aid; Decision Making; Decision Support Systems; Defect; design; Device Designs; device physics; Devices; Dimensions; Distal; Elements; Eligibility Determination; Engineering; experience; Face; Failure; Feasibility Studies; flexibility; Friction; Future; Generations; Graph; Heart failure; Human; Image; imaging platform; Implant; implantable device; implantation; improved; individual patient; Infant; Interdisciplinary Study; Intervention; Intuition; Investigation; Life; Measures; mechanical behavior; Mechanics; Medical Imaging; Methodology; Methods; Modeling; Morphology; Newborn Infant; novel; open source; Operative Surgical Procedures; Palliative Surgery; patient subsets; Patients; pediatric cardiologist; Pediatric Hospitals; Performance; Phase; Philadelphia; Population; Population Heterogeneity; preclinical study; Process; prototype; Pulmonary artery structure; Pulmonary Valve Insufficiency; pulmonary valve replacement; Pulmonary valve structure; reconstruction; Residual Tumors; Right ventricular structure; Scientist; screening; seal; Shapes; Sheep; simulation; Small Business Innovation Research Grant; Stents; Stress; System; Techniques; Time; tool; United States; Validation; valve replacement; Ventricular; verification and validation; Visualization; X-Ray Computed Tomography; ","Computer-Aided Decision Support System for Catheter-Based Pulmonary Valve Replacement","147747","ZRG1","Special Emphasis Panel ","","A1","01","","","221408",""
"10056490","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI151344","","PA-19-053","1R21AI151344-01A1","NIAID:281780\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","","07","048682157","US","1531401","SEATTLE CHILDREN'S HOSPITAL","WA","981053901","NARRATIVE Malaria kills approximately half of a million people annually. One of the major hurdles to malaria eradication is the ability of Plasmodium vivax to form hypnozoites, dormant liver stages that can remain within the host for years and lead to relapses. This proposal seeks to assess host factors that change upon, and are necessary for, P. vivax developing and dormant parasites, with the long-term goal of using this information to eliminate relapsing malaria.","10312234; ","KAUSHANSKY, ALEXIS ;","PESCE, JOHN T","05/22/2020","04/30/2022","Antibodies; base; Cell physiology; Cells; Collaborations; Data; Detection; Development; differential expression; digital; Disease; Disease model; Drug Targeting; Ensure; Event; experimental study; Goals; Health; Hepatocyte; Host Defense; Human; in vivo; Individual; Infection; inhibitor/antagonist; insight; Integration Host Factors; Intervention; kinase inhibitor; knock-down; Knowledge; Laboratories; Lead; Liver; liver infection; Machine Learning; Malaria; malaria infection; Measures; Methodology; Monitor; Morbidity - disease rate; mortality; Mus; novel; novel strategies; Oligonucleotides; Onset of illness; Parasites; pathogen; Pathway Analysis; Pharmaceutical Preparations; Phenotype; Phosphoproteins; Phosphorylation; Phosphotransferases; Plasmodium; Plasmodium vivax; Plasmodium yoelii; Play; Prevalence; Process; Production; Property; Proteins; Recording of previous events; Regulation; Regulatory Pathway; Relapse; Research Personnel; Rodent; Role; Sampling; side effect; Signal Transduction; small hairpin RNA; small molecule; Sporozoites; Symptoms; System; Testing; Toxic effect; Universities; Variant; Vivax Malaria; ","Elucidating host phosphosignaling regulation of Plasmodium vivax liver stage","151344","PTHE","Pathogenic Eukaryotes Study Section ","","A1","01","151920","129860","281780",""
"9854038","U54","AG","1","N","05/20/2020","09/01/2019","08/31/2020","","U54AG062322","","RFA-OD-19-013","1U54AG062322-01A1","NIA:143803\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE ON AGING","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","SLEEP RESOURCE CORE NARRATIVE The Sleep Resource Core (SRC) will be integrated into this SCORE by providing equipment, analysis, sleep- related expertise, and sleep data to the two human, one animal, and relevant Career Enhancement Core projects. The scientific leadership and technical support to facilitate and integrate rigorous collection, processing, analysis, and interpretation of sleep measures, will enable the SRC to promote interdisciplinary, collaborative, synergistic, and translational work and support the scientific and career enhancement goals of this SCORE. This work will expand the scientific impact of the SCORE by including sleep as a key health measure in human and animal models of women?s health and aging, including impacts on response to stress; body composition; neurological, cardiovascular, reproductive, and metabolic function; cognition; and mental health.","1912878; ","KLERMAN, ELIZABETH B.;","","","","actigraphy; Address; Affect; Age; Aging; Algorithms; Animal Experimentation; Animal Model; Animals; Area; Body Composition; Calibration; cardiometabolism; Cardiovascular system; career; Cognition; Cognitive; Collection; Communities; Data; Data Analyses; data cleaning; Data Collection; data de-identification; data integration; Databases; Dementia; demographics; Deposition; Devices; diaries; Disease; Disease Outcome; Education; Electroencephalography; Ensure; Equipment; experience; experimental study; Funding; Goals; Health; health difference; Hospitals; Hot flushes; Human; human model; Implanted Electrodes; indexing; Information Dissemination; innovation; inter-individual variation; Leadership; Link; Maintenance; Manuals; Manuscripts; Measurement; Measures; Mediating; medical schools; Mental Health; Metabolic; Modality; Monitor; Mus; Neurologic; neuroregulation; novel; Operative Surgical Procedures; Outcome; Outcome Measure; Participant; Performance; Perimenopause; Physiological; Physiology; Pilot Projects; Polysomnography; Postmenopause; Predisposition; Preparation; Prevalence; Process; programs; Protocols documentation; Quality Control; Questionnaires; Reading; reproductive; reproductive senescence; Research; Research Personnel; Research Project Grants; Research Support; Resources; response; Rest; Risk Factors; Rodent; Science; Secure; Sex Differences; Signal Transduction; Sleep; Sleep disturbances; sleep health; sleep onset; sleep quality; Sleeplessness; Stress; Symptoms; Syndrome; Teacher Professional Development; Techniques; Time; tool; Training; Training Support; United States National Institutes of Health; Variant; Vasomotor; web site; Woman; Women's Health; Work; Wrist; ","Sleep Resource Core","062322","ZRG1","Special Emphasis Panel ","7957","A1","01","91754","52049","","143803"
"9921224","U54","MD","5","N","05/18/2020","04/01/2020","03/31/2021","","U54MD010722","","RFA-MD-15-013","5U54MD010722-05","NIMHD:315461\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","7647381; ","DENNY, JOSHUA C.;","","","","Address; adverse childhood events; African American; base; Behavioral; biobank; Biological; Biomedical Research; Clinical; Clinical Data; clinical data warehouse; clinical practice; cohort; Collaborations; Collection; Communities; contextual factors; Country; Data; Data Analyses; data management; data mining; Data Set; Data Sources; data warehouse; Databases; Development; Diagnosis; disadvantaged population; Disease; DNA Library; Documentation; Educational Activities; Electronic Health Record; ethnic minority population; Etiology; food insecurity; Genetic; Genetic Diseases; Genetic Research; Genetic study; genomic data; Genomic medicine; Goals; Health; health data; health disparity; Hospitals; Housing; Individual; Infrastructure; Institutes; Institution; interest; Language; Latino; Life Style; lifestyle data; Link; literacy; Machine Learning; Medical Genetics; Methods; Minority; mortality; Natural Language Processing; Occupations; Office of Administrative Management; Other Genetics; Outcome; Pain; Patients; Pharmacogenomics; Phenotype; Population; population health; precision medicine; Process; prospective; Public Health; Publications; Race; racial minority; Regulation; repository; Research; Research Personnel; Research Support; Resources; Risk Factors; Sample Size; Science; shared decision making; Site; social; Social Environment; Social support; sociodemographics; socioeconomic disadvantage; Source; standard care; Taxonomy; Techniques; Terminology; Time; Underrepresented Populations; Universities; Work; ","Bio Repository Core","010722","ZMD1","Special Emphasis Panel ","8203","","05","244588","70873","","315461"
"9927566","UC7","AI","5","N","05/19/2020","05/01/2020","04/30/2021","","UC7AI094660","","RFA-AI-15-009","5UC7AI094660-10","NIAID:467803\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","GALVESTON","UNITED STATES","","14","800771149","US","578406","UNIVERSITY OF TEXAS MED BR GALVESTON","TX","775555302","National Biocontainment Laboratories Operational Support ensures the availability of  maximum containment laboratories for research that will develop the next generation of  therapeutics, diagnostics and vaccines for infectious diseases that can pose a public  health risk. It also ensures that high containment labs are available in the event of a  public health or bioterrorism emergency. This support is essential due to the high cost  of building and maintaining laboratories that protect researchers, ensure the biosecurity  of dangerous pathogens, and safeguard the communities where these laboratories are  located.","14306332; ","NTIFORO, CORRIE ;","","","","animal care; Animals; Appropriateness Review; biodefense; Biological; biosafety level 4 facility; biosecurity; Bioterrorism; Communicable Diseases; Communities; Consultations; Containment; cost; Dangerousness; data quality/integrity; Diagnostic; Education; Emergency response; Emergency Situation; Emerging Communicable Diseases; Employee Health; Ensure; Environmental air flow; Environmental Health; Equipment and supply inventories; Event; Exposure to; Foundations; Funding; Goals; Grant; Guidelines; Health; Health Personnel; Human Resources; Individual; Infectious Agent; Infectious Diseases Research; Infrastructure; institutional biosafety committee; Laboratories; laboratory experience; Laboratory Research; Leadership; Length; Light; Maintenance; Medical; Medical center; member; Mentors; Microbiological Techniques; Microbiology; National Institute of Allergy and Infectious Disease; Noise; novel therapeutics; Occupational Health; Occupational Health Services; operation; pathogen; Physician Executives; Police; Police officer; pre-clinical; Principal Investigator; Procedures; programs; Public Health; public health emergency; Reading; Recombinant DNA; Regulation; Research; research facility; Research Personnel; Resources; response; Risk; Safety; Sampling; Services; Site; skills training; Techniques; Texas; theories; Training; Training Programs; United States National Institutes of Health; Universities; Vaccines; Veterinarians; Work; ","Environmental Health and Biosafety Regulations and Requirements Core - Galveston National Laboratory BSL4 Operations","094660","ZAI1","Special Emphasis Panel ","8722","","10","303048","164755","","467803"
"9919006","R01","NS","5","N","05/20/2020","05/01/2020","04/30/2021","853","R01NS105680","SCHOOLS OF ARTS AND SCIENCES","PA-16-160","5R01NS105680-03","NINDS:376519\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","TUCSON","UNITED STATES","NEUROSCIENCES","03","806345617","US","490201","UNIVERSITY OF ARIZONA","AZ","857210158","There are currently no treatments to block the axon degeneration process that is fundamental to many central and peripheral neurodegenerative diseases. Our work will yield important new knowledge about how axon and nerve terminal degeneration is controlled. In turn, we anticipate this information to be critical in designing interventions to delay or prevent axon degeneration and reduce the burden that neurodegenerative disorders place on our society.","7010667; ","BHATTACHARYA, MARTHA RUTH CHASE;","GUBITZ, AMELIE","07/01/2018","04/30/2023","Address; Affect; afferent nerve; Alzheimer's Disease; Amino Acids; Amyotrophic Lateral Sclerosis; Autophagocytosis; Autophagosome; Axon; axonal degeneration; Axonal Transport; base; Behavior; Behavioral; beta-arrestin; Biochemical; Biochemistry; Biological; Biotinylation; Cell Survival; Cells; Cellular biology; Cessation of life; Charcot-Marie-Tooth Disease; chemotherapy; chemotherapy induced neuropathy; Cyclic AMP; Data; Defect; Diabetes Mellitus; Diabetic Neuropathies; Disease; Drosophila genus; Eating; Electrophysiology (science); Event; fly; follow-up; functional restoration; G-Protein-Coupled Receptors; Genetic; genetic analysis; Genetic Diseases; Genetic Epistasis; Goals; Impairment; in vitro Assay; Inherited; injured; Injury; Integral Membrane Protein; Knowledge; Label; Life; Link; Lysosomes; Maintenance; MAP Kinase Gene; Measurement; Mediator of activation protein; Metabolic stress; Mitogen-Activated Protein Kinases; Mitotic; Modeling; Molecular; Molecular Analysis; Motor; multicatalytic endopeptidase complex; Mus; Muscle; mutant; Mutant Strains Mice; Natural regeneration; Nerve; Nerve Block; Nerve Crush; nerve injury; nervous system disorder; Nervous system structure; Neuraxis; Neurodegenerative Disorders; neuromuscular; Neurons; neurotoxicity; novel; Optic Nerve; Organelles; p38 Mitogen Activated Protein Kinase; Pain; pain behavior; Pathway interactions; Peripheral; Peripheral Nerves; Peripheral Nervous System; Pharmaceutical Preparations; Phenotype; Plant Roots; Play; preservation; prevent; Process; protein protein interaction; Proteins; recruit; Research; response to injury; Role; Sensory; Signal Pathway; Signal Transduction; Societies; Stress; Structure; Symptoms; Synapses; synaptic function; Synaptic Transmission; System; Tactile; Testing; therapy design; Tissues; Traumatic injury; Wallerian Degeneration; Work; ","Defining TMEM184b-Controlled Pathways in Nerve Terminal Maintenance and Axon Degeneration","105680","CMND","Cellular and Molecular Biology of Neurodegeneration Study Section ","","","03","245289","131230","376519",""
"10051832","R01","AI","1","N","05/20/2020","05/20/2020","04/30/2021","855","R01AI148557","BIOMED ENGR/COL ENGR/ENGR STA","PA-19-077","1R01AI148557-01A1","NIAID:492238\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","AMHERST","UNITED STATES","BIOMEDICAL ENGINEERING","26","038633251","US","5992614","STATE UNIVERSITY OF NEW YORK AT BUFFALO","NY","142282567","PROJECT NARRATIVE There is a need for an effective vaccine that blocks the transmission of malaria. We will design a vaccine by ?focusing? the immune response towards the same target epitope of a potent monoclonal antibody against Pfs48/45, an antigen candidate which we recently solved the structure of. The vaccine will be tested in the context of a next-generation vaccine adjuvant we developed which spontaneously converts well-characterized protein antigens into large particles with significantly greater immunogenicity.","11340910; 11262023 (contact); ","JULIEN, JEAN-PHILIPPE ; LOVELL, JONATHAN F (contact);","MO, ANNIE X Y","05/20/2020","04/30/2025","Adjuvant; Affect; Antibodies; Antibody Response; Antibody titer measurement; Antibody-mediated protection; Antigen Targeting; Antigens; base; Binding; Biological; Blocking Antibodies; Clinical; Clinical Research; Cobalt; Communication; Complement; Complex; Consumption; Crystallization; Culicidae; density; Dependence; design; Development; Disease; Epitopes; follow-up; Formulation; Future; Germ Cells; glycosylation; Human; Immune response; Immunity; Immunization; immunogenicity; Immunoglobulin G; Interruption; Life; Liposomes; Malaria; malaria transmission; malaria transmission-blocking vaccine; Malaria Vaccines; Masks; Midgut; Modification; Monoclonal Antibodies; Mutation; nanoliposome; Nanotechnology; Nature; next generation; NIH Program Announcements; novel vaccines; Parasites; particle; Phospholipids; Plasmodium falciparum; Population; Porphyrins; preclinical toxicity; Production; Proteins; Publishing; Recombinants; Reproduction; Research; Resources; response; Risk; Safety; Serum; Structure; System; Technology; Testing; three dimensional structure; Time; Toxic effect; Toxin; transmission process; transmission-blocking vaccine; Vaccination; Vaccine Adjuvant; Vaccine Antigen; vaccine candidate; vaccine discovery; vaccine efficacy; Vaccines; Viral Vector; Virus-like particle; World Health Organization; ","Rationally-Designed, Spontaneous-Particleized Pfs48/45 for a Multivalent Malaria Vaccine","148557","VMD","Vaccines Against Microbial Diseases Study Section ","","A1","01","372916","119322","492238",""
"10104047","R01","NS","3","N","05/18/2020","05/01/2020","11/30/2020","853","R01NS112516","SCHOOLS OF MEDICINE","PA-18-906","3R01NS112516-01S1","NINDS:47266\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","CHARLOTTESVILLE","UNITED STATES","NEUROSCIENCES","05","065391526","US","1526402","UNIVERSITY OF VIRGINIA","VA","229044195","PROJECT NARRATIVE Infections within the brain can cause irreparable damage. We will study how the immune system eliminates infection in specific locations within the brain. By understanding the triggers that draw immune cells to discrete regions of the brain, therapies can be developed that either promote the clearance of infections or prevent unwanted inflammation.","8021288; ","HARRIS, TAJIE HEARTSONG;","WONG, MAY","02/01/2020","11/30/2023","Address; Adult; Affect; Alzheimer's Disease; Antiparasitic Agents; Area; Astrocytes; Blood Vessels; Brain; brain endothelial cell; Brain region; CCL2 gene; Cell Adhesion Molecules; Cell Death; cell type; Cells; Central Nervous System Infections; chemokine; Chemotaxis; Chronic; chronic infection; Cyst; Data; Defect; Disease Progression; Endothelial Cells; Endothelium; Extravasation; gray matter; Immune; Immune response; Immune system; Immunity; Infection; Infection Control; Inflammasome; Inflammation; Inflammatory; Innate Immune Response; interest; Interferons; Interleukin-1; Interleukin-1 Receptors; Lead; Link; Location; macrophage; Mediating; Microglia; mild cognitive impairment; mind control; monocyte; multiphoton microscopy; Mus; Myeloid Cells; Nerve Degeneration; Neuraxis; Neuroglia; neuroinflammation; Oligodendroglia; Parasite Control; Parasites; Parasitic infection; pathogen; Pathway interactions; prevent; Production; Proteins; Publications; Reaction; receptor; recruit; response; Signal Transduction; Signaling Molecule; Single Nucleotide Polymorphism; Site; Source; STAT1 gene; System; T-Lymphocyte; Testing; therapeutic development; Tissues; Toxoplasma gondii; Toxoplasmosis; trafficking; transcriptome sequencing; ","Alarmin-mediated control of CNS infection","112516","","","","S1","01","31147","16119","47266",""
"10167224","U19","AI","3","N","05/18/2020","05/18/2020","07/31/2020","","U19AI128913","","PA-18-591","3U19AI128913-03S1","NIAID:869489\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","11417979; ","BUNNAPRADIST, SUPHAMAI ;","ROBIEN, MARK ANDREW","05/18/2020","07/31/2021","","Core A: Clinical","128913","","","9111","S1","03","557365","312124","","869489"
"9970495","T32","HD","5","N","05/18/2020","05/01/2020","04/30/2021","865","T32HD049336","SCHOOLS OF ARTS AND SCIENCES","PA-14-015","5T32HD049336-15","NICHD:209995\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","BLOOMINGTON","UNITED STATES","BIOLOGY","09","006046700","US","577805","INDIANA UNIVERSITY BLOOMINGTON","IN","474013654","PUBLIC HEALTH RELEVANCE: Understanding the sexual phenotype - or gender - has far reaching implications for human health and well- being. Trainee research on steroid hormones, maternal stress, changing environments, maternal and infant health, and healthy sexual behavior and reproduction, using human, non-human model systems, and evolutionarily diverse non-model systems will lead to insights into the basic mechanisms of reproduction and development and to understanding of the physiological differences between the sexes and their influence on illness and health outcomes, all of which will be valuable to policy makers, medical research, and health care.","7722048; ","KETTERSON, ELLEN D;","TAYMANS, SUSAN","05/01/2005","04/30/2021","reproductive; ","Common Themes in Reproductive Diversity","049336","ZHD1","Special Emphasis Panel ","","","15","269432","17715","209995",""
"10113076","R01","DK","7","N","05/19/2020","04/01/2020","03/31/2021","847","R01DK110183","SCHOOLS OF MEDICINE","PA-18-590","7R01DK110183-04","NIDDK:368438\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BALTIMORE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Project Narrative In this proposal, ?Regulation of mature ?-cell function by the transcription factor FoxM1,? we will investigate how FoxM1 differentially regulates its targets in males and females. We will also examine the mechanism by which FoxM1 distinguishes between cell cycle genes and genes involved in ?-cell function. Finally, we will use discovery-based and hypothesis-driven approaches to find the functional targets of FoxM1 in the ?-cell.","9757724; ","GOLSON, MARIA L;","SATO, SHERYL M","04/01/2017","03/31/2022","Ablation; Adult; Affect; Affinity; Age; aged; Attenuated; B Cell Proliferation; base; Beta Cell; Binding; Binding Sites; bioinformatics tool; Biological; Biological Assay; cdc Genes; Cell Cycle; Cell Cycle Progression; Cell division; Cell physiology; cell type; Cells; chromatin immunoprecipitation; Consensus Sequence; CRISPR/Cas technology; Data; Development; Diabetes Mellitus; diabetes mellitus therapy; Disease; DNA Sequence; druggable target; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptors; Estrogen Therapy; Estrogens; Evaluation; Event; experimental study; Failure; Female; FOXM1 gene; Frequencies; Future; Gender; Genes; Genetic; Genetic Transcription; genome-wide; Glucose; glucose tolerance; Goals; Grant; Human; Immunoprecipitation; improved; Insulin; Insulin Resistance; insulin secretion; islet; Islets of Langerhans; Knowledge; Ligation; loss of function; male; Masks; Mass Spectrum Analysis; Mature B-Lymphocyte; Mediating; Menopause; Mining; Modeling; Modernization; Mus; Mutagenesis; nodal protein; Non-Insulin-Dependent Diabetes Mellitus; novel; novel therapeutics; Obesity; Pancreas; Performance; Pharmacology; Phenotype; Positioning Attribute; postnatal; Proliferating; Regulation; Research; restoration; Role; Signal Transduction; Site; Testing; therapeutic target; Tissues; transcription factor; transcriptome sequencing; Transgenic Mice; United States; Work; ","RESEARCH REGULATION OF MATURE BETA CELL FUNCTION BY THE TRANSCRIPTION FACTOR FOXM1","110183","CADO","Cellular Aspects of Diabetes and Obesity Study Section ","","","04","225000","143438","368438",""
"9918163","IK2","VA","5","N","05/21/2020","04/01/2020","03/31/2021","999","IK2RX002922","","RFA-RX-18-016","5IK2RX002922-02","","OTHERS","2020","Veterans Affairs","","MINNEAPOLIS","UNITED STATES","","05","071774624","US","481047","MINNEAPOLIS VA  MEDICAL CENTER","MN","554172309","Mild traumatic brain injury (mTBI) is one of the most common conditions afflicting combat veterans. Though most individuals experience a full recovery after mTBI, a so-called ?miserable minority? experience persistent symptoms of post-concussive syndrome (PCS), even after pursuing rehabilitative treatment. Growing evidence suggests that the presence of non-injury factors, such as mental illness, might cause PCS symptoms to persist. As such, genes that confer risk for conditions related to mTBI (such as posttraumatic stress disorder) could be used to predict mTBI outcomes and recovery. This proposed project will seek to identify the extent that genetic risk for related conditions predicts the persistence of PCS as well as outcomes from mTBI treatment. Identifying factors that could predict mTBI outcomes and recovery would have great utility for clinicians, as it would allow them to make more informed and personalized decisions about treatment recommendations.","11033557; ","DISNER, SETH GORDON;","","04/01/2019","03/31/2024","Address; Affect; Afghanistan; Alleles; Alzheimer's Disease; Attention deficit hyperactivity disorder; Biological Factors; Candidate Disease Gene; Caring; Categories; Childhood; Chronic; Clinic; Clinical; Cognitive; combat; Communities; comorbidity; Complex; computerized; Conflict (Psychology); Craniocerebral Trauma; Data; Department of Defense; Development; Diagnosis; Disease; disorder risk; Effectiveness; Environment; environmental stressor; Etiology; European; experience; Failure; falls; follow-up; gene environment interaction; Genes; Genetic; Genetic Predisposition to Disease; genetic profiling; Genetic Research; Genetic Risk; genome wide association study; genome-wide; Genomics; Genotype; Health; Healthcare Systems; Impairment; improved; indexing; Individual; Injury; innovation; Intelligence; Intervention; Iraq; Light; Link; Literature; Major Depressive Disorder; Mental disorders; mild traumatic brain injury; Military Personnel; Minority; Nervous System Trauma; Neurologic; Neurological status; Outcome; Outpatients; Parkinson Disease; Participant; Pattern; persistent symptom; Personal Satisfaction; personalized decision; personalized intervention; personalized predictions; Persons; Phase; phenome; Phenotype; phenotypic data; Physical Medicine; Physical Rehabilitation; Play; Post-Concussion Syndrome; Post-Traumatic Stress Disorders; precision genetics; Prediction of Response to Therapy; Prevalence; psychologic; Psychopathology; Quality of life; Recommendation; Recording of previous events; Records; Recovery; Recovery of Function; recruit; Rehabilitation Centers; Rehabilitation Outcome; Rehabilitation Research; rehabilitation service; Rehabilitation therapy; rehabilitative care; relating to nervous system; Relative Risks; Research; Risk; risk variant; Role; Sampling; Schizophrenia; service member; Source; Sum; Symptoms; TBI treatment; Testing; Time; trait; Trauma; Traumatic Brain Injury recovery; traumatic event; United States Dept. of Health and Human Services; Validation; Variant; Veterans; whole genome; Work; working group; ","Exploring polygenic risk as a means for personalizing TBI rehabilitation","002922","RRD8","Career Development Program - Panel I ","","","02","","","",""
"9914301","R35","GM","5","N","05/19/2020","05/01/2020","04/30/2021","859","R35GM122566","ORGANIZED RESEARCH UNITS","RFA-GM-17-002","5R35GM122566-05","NIGMS:1057680\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","TEMPE","UNITED STATES","MISCELLANEOUS","09","943360412","US","488301","ARIZONA STATE UNIVERSITY-TEMPE CAMPUS","AZ","852876011","This project is focused on the molecular-genetic mechanisms associated with the production of variation in organismal diversity, and the consequences for organismal fitness. The research will generate a comprehensive empirical and theoretical understanding of the rates at which cellular errors arise at the DNA, RNA, and protein levels, and reveal the degree to which heritable mutations of various types and recombination rates have negative vs. positive fitness effects.","1898380; ","LYNCH, MICHAEL R;","JANES, DANIEL E","05/01/2017","04/30/2022","Amino Acids; Architecture; Automobile Driving; Code; Collection; comparative; Daphnia; Development; Diploidy; DNA; DNA biosynthesis; egg; Environment; Evaluation; Evolution; Fertilization; fitness; Gene Structure; Genes; Genetic; Genetic Diseases; Genetic Recombination; Genetic Transcription; Genome; genome sequencing; Geography; Haploidy; Health; Heritability; Human; insight; Introns; Lead; Long-Term Effects; Malignant Neoplasms; Measures; Meiosis; Meiotic Recombination; Messenger RNA; Methods; Modeling; Molecular; Molecular Genetics; Mutation; Natural Selections; pathogen; Pattern; Phylogenetic Analysis; Population; Population Genetics; Population Sizes; Production; protein aggregation; Proteins; Research; Ribonucleotides; RNA; Source; structural genomics; Surveys; System; Testing; theories; Time; Toxic effect; trait; Translations; Variant; whole genome; Work; ","Causes and Population-genetic Consequences of Molecular Variation","122566","ZGM1","Special Emphasis Panel ","","","05","680394","377286","1057680",""
"10158965","U01","AI","3","N","05/19/2020","05/19/2020","03/31/2021","855","U01AI131344","SCHOOL OF MEDICINE & DENTISTRY","PA-18-591","3U01AI131344-04S1","NIAID:282884\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ROCHESTER","UNITED STATES","PEDIATRICS","25","041294109","US","7047101","UNIVERSITY OF ROCHESTER","NY","146270140","This study will collect breast milk, breast swabs (pre- and post-washing) and maternal blood from COVID-19+ breastfeeding mothers for 90 days to assess the risks and benefits of breastfeeding during that time. We will assess infant exposure to the virus on the breast and/or in breast milk and protective benefits by profiling SARS-CoV-2 specific antibodies in breast milk and these antibodies' ability to neutralize the virus. Understanding when antibodies appear in breast milk and if/when virus is present in these samples will help us make better recommendations and provide better care to mothers and infants.","10365931; ","JARVINEN-SEPPO, KIRSI ;","DAVIDSON, WENDY F","05/19/2020","03/31/2022","2019-nCoV; Antibodies; Antibody Response; Antibody-Dependent Enhancement; Bangladeshi; base; Benefits and Risks; Birth; Blood; Blood Circulation; Breast; Breast Feeding; Caring; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Conflict (Psychology); Consumption; Coronavirus; COVID-19; cross reactivity; Dengue; Dentistry; design; Detection; Development; diarrheal disease; Disease; Disease Progression; Enrollment; evidence base; evidence based guidelines; Exclusive Breastfeeding; Exposure to; Family; febrile infant; Fever; Fingers; Food Hypersensitivity; Freezing; genomic RNA; Handwashing; Health; Home environment; Hospitals; Human Milk; Immunity; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologic Factors; improved; in vitro Assay; Infant; Infant Health; infant outcome; Infection; Influenza; Influenza A virus; Influenza Hemagglutinin; Institutional Review Boards; Lactation; Life; Location; Longitudinal cohort study; Masks; maternal vaccination; Measures; medical schools; Methods; Milk; Mothers; Mucous Membrane; Neisseria meningitidis; neutralizing antibody; New Caledonia; New York; novel coronavirus; pandemic disease; Parents; Participant; pathogen; Patients; Pattern; perinatal period; Pertussis; Play; Policies; Pregnancy; pregnant; Pregnant Women; protective factors; Proteins; Provider; Pump; Recommendation; recruit; Reporting; respiratory; response; Risk; Risk Factors; RNA; RNA analysis; Role; sample collection; Sampling; Serum; Severe Acute Respiratory Syndrome; Site; Skin; social media; Streptococcus pneumoniae; Swab; Symptoms; System; Time; transmission process; Uncertainty; Universities; Vaccinated; Vaccines; Viral; viral RNA; viral transmission; Virus; Virus Diseases; Vulnerable Populations; Whole Blood; Woman; ","Development of Mucosal and Systemic Immunity and Risk of Food Allergy","131344","ZAI1","Special Emphasis Panel ","","S1","04","206841","76043","282884",""
"9918161","I01","VA","5","N","05/21/2020","04/01/2020","03/31/2021","999","I01RX001799","","RFA-RX-15-003","5I01RX001799-05","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","PALO ALTO","UNITED STATES","","18","046017455","US","481014","VETERANS ADMIN PALO ALTO HEALTH CARE SYS","CA","943041207","PUBLIC HEALTH RELEVANCE    Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke. Obesity, a growing problem for Americans and Veterans alike, is the greatest risk factor for the development of OSA. Male gender and smoking, other OSA risk factors, are common in Veterans. Given the high comorbidity of these risk factors in Veterans, OSA presents a significant health burden to Veterans. Our prior work provides evidence that OSA occurs in up to 69% of Vietnam-era Veterans with PTSD. OSA is easily treated; however, 15-30% of OSA patients are non- compliant with continuous positive airway pressure (CPAP), the standard OSA treatment. The proposed research aims to facilitate adherence to CPAP treatment by testing a novel cognitive-behavioral therapy intervention in Veterans with PTSD. If successful, it may represent an approach that could be applied to the rehabilitation of other chronic conditions with similar barriers to care.","12232645; ","KINOSHITA, LISA M.;","","04/01/2016","03/31/2021","Address; Adherence; Aging; American; Analysis of Covariance; Appointment; arm; Arts; Auditory; Award; barrier to care; behavior change; Caring; Chronic; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Cognitive Therapy; comorbidity; Complex; Continuous Positive Airway Pressure; daily functioning; Data; Data Analyses; Data Set; Databases; Dementia; design; Deterioration; Development; Diagnosis; disability; Doctor of Philosophy; DSM-V; Elderly; Environment; Epidemiology; epidemiology study; Evidence based practice; Fostering; functional disability; functional outcomes; Gender; Goals; Health; Healthcare Systems; Hour; Hypoxemia; Impaired cognition; improved; improved outcome; Individual; Individual Differences; International; Intervention; intervention effect; Lead; Longevity; Lung; male; Masks; Measures; Mediating; Mediator of activation protein; Medical; Medicine; Memory; middle age; Moods; Myocardial Infarction; nerve injury; non-compliance; novel; Obesity; Obstructive Sleep Apnea; Outcome; Participant; patient oriented; Patient Self-Report; Patients; physical conditioning; Physicians; post intervention; Post-Traumatic Stress Disorders; primary endpoint; programs; Protocols documentation; Provider; Psychiatrist; psychologic; Psychologist; public health relevance; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Recurrence; Rehabilitation Research; Rehabilitation therapy; Reporting; Research; research and development; Research Design; Research Personnel; Resources; Respiratory Signs and Symptoms; Respiratory Therapy; response; Risk; Risk Factors; Sampling; Scientist; screening; Self Efficacy; Services; Severities; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Fragmentations; Sleeplessness; Smoking; software systems; Source; Specialist; standard of care; Statistical Data Interpretation; Stroke; Symptoms; Techniques; Testing; Therapeutic Intervention; Time; Training; trauma exposure; treatment adherence; treatment as usual; Verbal Learning; Veterans; Vietnam; Visit; War; Work; ","Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans with PTSD","001799","RRD4","Behavioral Health & Social Reintegration ","","","05","","","",""
"9927575","R01","AR","5","N","05/19/2020","05/01/2020","04/30/2021","846","R01AR070750","SCHOOLS OF MEDICINE","PA-13-302","5R01AR070750-04","NIAMS:434443\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","PHILADELPHIA","UNITED STATES","ORTHOPEDICS","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Rotator cuff disorders of the shoulder are particularly devastating in the aging population with tears more common in people over 60. Normal development and maturation processes, along with cues from the mechanical loading environment, generate and remodel tendon structure and composition throughout life. These processes are regionally-dependent, suggesting a complex spatially-dependent regulation of tendon homeostasis. During aging, normal maturation processes and mechanical influences can result in accumulation of sub-rupture damage leading to tendon degeneration. The focus of this application is to determine the mechanisms by which collagen V differentially regulates structure and function at the insertion site and midsubstance of the supraspinatus tendon at maturity and during the aging process.","1879623; ","SOSLOWSKY, LOUIS J;","KIRILUSHA, ANTHONY G","05/01/2017","04/30/2022","age related; aged; Aging; aging population; Collagen; Complex; Coupled; Cues; Development; Disease; Environment; Fatigue; Fiber; fibrillogenesis; Homeostasis; Inferior; innovation; Leucine; Life; Measures; mechanical load; mechanical properties; Mechanics; Minor; Modeling; Morphology; mouse model; Mus; novel; Premature aging syndrome; Process; Property; Proteoglycan; Recovery; Regulation; response; Role; Rotator Cuff; Rupture; Shoulder; Site; Slide; Structure; Structure-Activity Relationship; supraspinatus muscle; tendon development; Tendon structure; Testing; Tissues; ","Differential Roles of Collagen V in Establishing the Regional Properties in Mature and Aging Supraspinatus Tendons","070750","SBSR","Skeletal Biology Structure and Regeneration Study Section ","","","04","336393","98050","434443",""
"10159107","I01","VA","5","N","05/17/2020","04/01/2020","03/31/2021","999","I01HX002093","","RFA-HX-16-005","5I01HX002093-04","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","INDIANAPOLIS","UNITED STATES","","07","608434697","US","481029","RLR VA MEDICAL CENTER","IN","462022803","VHA is transforming its acute mental health inpatient care to better align with recovery- oriented services. Inpatient care should include recovery-oriented policies and procedures, self-management education, shared decision-making, and access to evidence-based psychotherapy, all provided by an interdisciplinary treatment team. Despite policies and resources devoted to this transformation, little is known regarding the roll-out within VHA. More specifically, this project will utilize a concurrent triangulation mixed-methods design to examine the penetration or recovery-oriented inpatient programming within VHA, the process of implementing these services, and the effects on Veterans? outcomes. Results will be used by the VHA Office of Mental Health Operations to formulate and deploy resources to support recovery-oriented inpatient programming.","10718851; ","MCGUIRE, ALAN BENJAMIN;","","04/01/2017","03/31/2021","Acute; acute care; addiction; Affect; base; Caring; clinical care; Data; Data Collection; design; Education; Elements; Emergency department visit; empowerment; Ethics; Evaluation; evidence base; Evidence based treatment; experience; Future; Guidelines; handbook; health administration; Healthcare; implementation research; improved; Incentives; inpatient service; Inpatients; Interview; Investigation; Link; Literature; Measures; Medication Management; Mental disorders; Mental Health; Mental Health Services; Methods; operation; Outcome; outpatient programs; Outpatients; patient engagement; Patient Preferences; Patient-Centered Care; Patient-Focused Outcomes; Patients; Penetration; person centered; Policies; Population; Procedures; Process; Psyche structure; Psychotherapy; Publishing; readmission rates; Recovery; Relapse; Reporting; Research; Resources; response; Sampling; Self Management; Services; shared decision making; Site; Site Visit; Standardization; Surveys; Testing; Time; uptake; Veterans; ","Evaluation of Recovery-oriented Acute INpatient Mental Healthcare (RAIN-MH)","002093","HSR4","HSR-4  Mental and Behavioral Health ","","","04","","","",""
"9843688","R01","HL","5","N","05/18/2020","01/01/2020","12/31/2020","839","R01HL136255","SCHOOLS OF MEDICINE","PA-16-039","5R01HL136255-04","NHLBI:423118\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NEW YORK","UNITED STATES","ANATOMY/CELL BIOLOGY","13","078861598","US","3839801","ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI","NY","100296574","Project Narrative Anemia is a major health problem affecting human populations. Production of red blood cell (RBC) in vitro for clinical use is an achievable goal that is hampered by lack of sufficient knowledge of RBC formation. Studies proposed here are designed to elucidate the function of novel molecules/pathways implicated in RBC formation and their impact on RBC disorders specifically ? thalassemia.","2106196; ","GHAFFARI, SAGHI ;","QASBA, PANKAJ","01/01/2017","12/31/2020","Affect; Anemia; Anemia due to Chronic Disorder; Apoptosis; Apoptotic; base; beta Thalassemia; biological adaptation to stress; Bone Marrow; CD34 gene; CDC42 gene; cell motility; Cell Nucleus; Cells; Chronic; Chronic stress; Clinical; design; Disease; Ectopic Expression; Erythroblasts; Erythrocytes; Erythroid; Erythroid Cells; Erythropoiesis; Family member; FOXO3A gene; Functional disorder; gain of function; Gene Cluster; Genes; Genetic; Genetic Diseases; Genomics; Goals; Guanosine Triphosphate Phosphohydrolases; Health; Hematopoiesis; Hemoglobinopathies; Human; improved; In Vitro; Knowledge; Mediating; Mediator of activation protein; Methodology; Mitochondria; Modeling; mouse model; Mus; novel; Nuclear; organelle movement; Oxidation-Reduction; Oxidative Stress; Pathway interactions; Pattern; Physiological; Physiological Processes; Polycythemia Vera; Population; Process; Production; Property; Publishing; quantitative imaging; Regulation; response; rho GTP-Binding Proteins; Role; Side; Spleen; Stress; Testing; Therapeutic; transcription factor; ","FOXO3 Regulation of Normal and Stress Erythropoiesis","136255","ZRG1","Special Emphasis Panel ","","","04","250000","173118","423118",""
"9854041","U54","AG","1","N","05/20/2020","09/01/2019","08/31/2020","","U54AG062322","","RFA-OD-19-013","1U54AG062322-01A1","NIA:388190\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE ON AGING","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","NARRATIVE Reproductive aging in women (i.e., menopause) leads to a number of distressing physiological alterations associated with the decrease in circulating estrogens, among which vasomotor symptoms (also referred to as hot flashes) significantly disrupt sleep and disturb quality of life and may be relevant to subsequent risk of adverse health outcomes such as cardiovascular disease and dementia. Stress can affect the severity of vasomotor symptoms; however, the mechanisms underlying the control of thermoregulation by sex steroids and how this can be modulated by stress remain unknown. We aim to address this knowledge gap by using a series of genetic, behavioral and pharmacological approaches to identify the neuronal circuitry connecting the reproductive axis, stress, thermoregulation, and sleep quality.","1896176; ","KAISER, URSULA B.;","","","","Ablation; Address; Adrenal Cortex Hormones; Adverse effects; adverse outcome; Affect; Aging; Alzheimer's Disease; Alzheimer's disease risk; base; behavioral pharmacology; cardiometabolic risk; cardiometabolism; Cardiovascular Diseases; cardiovascular disorder risk; Cells; Dementia; dementia risk; Development; Disease susceptibility; disorder risk; Distress; Dynorphin A; Dynorphins; Estradiol; Estrogens; experience; Female; Fibrinogen; GABA Receptor; gamma-Aminobutyric Acid; Genetic; Glucocorticoid Receptor; Glucocorticoids; Goals; Gonadal Steroid Hormones; Gonadotropin Hormone Releasing Hormone; Health; High temperature of physical object; Hormone secretion; Hormones; Hot flushes; hypercortisolemia; hypothalamic pituitary gonadal axis; Hypothalamic structure; Impairment; improved; insight; KISS1 gene; Knowledge; Link; Malignant Neoplasms; Mediating; Mediator of activation protein; Menopause; Modeling; mouse genetics; mouse model; Mus; neural circuit; Neurokinin B; neuronal circuitry; Neurons; Neuropeptides; neuroregulation; novel strategies; Obesity; Outcome; Pathway interactions; Patients; Peripheral; Physiologic Thermoregulation; Physiological; Play; Predisposition; Quality of life; Regulation; Reproduction; reproductive axis; reproductive function; Reproductive Health; reproductive senescence; restraint stress; Risk; Role; Series; Severities; Sleep; Sleep disturbances; sleep pattern; sleep quality; Stress; stress symptom; stressor; Structure of nucleus infundibularis hypothalami; Sweating; Symptoms; Tachykinin; Testing; Time; tool; Vasodilation; Vasomotor; Woman; Work; ","Deciphering the interactions of stress, corticosteroids, and Kiss1 neurons in reproduction and vasomotor symptoms in aging females","062322","ZRG1","Special Emphasis Panel ","7960","A1","01","260971","127219","","388190"
"9854036","U54","AG","1","N","05/20/2020","09/01/2019","08/31/2020","","U54AG062322","","RFA-OD-19-013","1U54AG062322-01A1","NIA:146398\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE ON AGING","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","LEADERSHIP ADMINISTRATIVE CORE NARRATIVE The Leadership Administration Core (LAC) will oversee the scientific agenda and administration of the research Projects, Career Enhancement Core, and Sleep Resource Core of the Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes. The LAC will also ensure engagement of the Brigham/Harvard SCORE with the broader SCORE research consortium. The LAC will support investigators in achieving the translational aims outlined in the respective Projects and Cores. Our overarching goals are to advance our understanding of stress exposures and neural regulation of reproductive aging health outcomes and catalyze the growth of interdisciplinary and translational women?s health and sex-differences research.","6684491; ","JOFFE, HADINE ;","","","","Aging; Award; Biological; Biology; brain health; cardiometabolism; Cardiovascular system; career; Characteristics; Cognitive; Cognitive aging; Collaborations; Communication; Communities; Dementia; dementia risk; Ensure; Environment; Fostering; Foundations; Future; Gender; Goals; Growth; Health; health difference; Health Policy; Hospitals; Infrastructure; innovation; interdisciplinary collaboration; International; Investigation; Lead; Leadership; medical schools; Medicine; Menopause; Monitor; neuroregulation; Neurosciences; Outcome; Performance; Pilot Projects; Policies; policy implication; Predisposition; Productivity; programs; reproductive senescence; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; sex; Sex Differences; Site; Sleep; Sleep disturbances; Stress; symposium; Symptoms; synergism; Therapeutic; Time; Translating; Translational Research; Translations; Travel; United States National Institutes of Health; Vasomotor; Woman; Women's Health; ","Leadership Administrative Core","062322","ZRG1","Special Emphasis Panel ","7955","A1","01","93410","52988","","146398"
"9992359","F32","HD","1","N","04/09/2020","05/01/2020","04/30/2021","865","F32HD102182","ORGANIZED RESEARCH UNITS","PA-19-188","1F32HD102182-01","NICHD:69306\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","EUGENE","UNITED STATES","NEUROSCIENCES","04","079289626; 948117312","US","6297005","UNIVERSITY OF OREGON","OR","974035219","PROJECT NARRATIVE Every thought and action we experience is elegantly organized by passing information through specific, specialized connections in the brain called synapses. Yet, we fundamentally do not understand how the many different types of synapses form during development, nor how they coordinate their numbers to balance one another in a neural circuit. This proposal explores the mechanisms by which synapses coordinate their development which is critical for us to understand the basis of neurodevelopmental disorders such as autism and epilepsy, and for us to devise rational therapeutic interventions.","14313637; ","MARTIN, ELIZABETH ANNE;","HENKEN, DEBORAH B","05/01/2020","04/30/2023","Adult; Animal Model; autism spectrum disorder; Binding; Biochemical; Biochemistry; Biological; Biological Assay; Biological Models; Biological Process; Biology; Brain; Cells; Cellular biology; Chemical Synapse; Chemicals; Clustered Regularly Interspaced Short Palindromic Repeats; collaborative environment; Complex; Dendrites; design; Development; Dissection; Electrical Synapse; Embryo; Epilepsy; Equilibrium; experience; Fellowship; Foundations; gap junction channel; Genes; Genetic; Goals; Golgi Apparatus; Grant; Growth; Image; In Vitro; in vivo; innovation; insight; Institution; Investigation; Knowledge; Learning; Ligation; Light; Manuscripts; Mauthner's neuron; Mediating; Membrane Proteins; Mentors; Molecular; Nervous system structure; neural circuit; Neurodevelopmental Disorder; Neurons; Neurotransmitters; Oregon; Organ; Pattern; Population; Positioning Attribute; post-doctoral training; Process; protein distribution; protein transport; Proteins; Recycling; Regulation; Research; Research Methodology; Research Personnel; Role; statistics; Stereotyping; supportive environment; Synapses; synaptogenesis; Techniques; Tertiary Protein Structure; Therapeutic Intervention; Time; trafficking; Training; Universities; Vertebrates; Writing; Zebrafish; ","Molecular Mechanisms of Synapse Coordination","102182","ZRG1","Special Emphasis Panel ","","","01","69306","","69306",""
"10148297","R01","AI","3","N","05/19/2020","05/19/2020","08/31/2020","855","R01AI150274","SCHOOLS OF MEDICINE","PA-18-591","3R01AI150274-01S1","NIAID:157244\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","OMAHA","UNITED STATES","SURGERY","02","168559177","US","578104","UNIVERSITY OF NEBRASKA MEDICAL CENTER","NE","681987835","Project Narrative Environmental agents are important for triggering autoimmune diseases such as Type 1 Diabetes (T1D). This project seeks to determine whether Cytomeglovirus infection is the triggering agent for T1D. The work will lead to new anti-viral treatments for preventing T1D.","2406206; ","SARVETNICK, NORA E;","RICE, JEFFREY S","05/19/2020","08/31/2021","Advocate; antigen-specific T cells; Antigens; Antiviral Agents; Antiviral Response; Antiviral Therapy; Autoantibodies; Autoimmune Diseases; Autoimmune Process; Autoimmunity; autoreactive T cell; autoreactivity; Biological Markers; C-Peptide; CD8-Positive T-Lymphocytes; CD8B1 gene; Cesarean section; Child; chronic infection; Clinic; Clinical; Collaborations; cost; Coxsackie Viruses; Cytomegalovirus; Cytomegalovirus Infections; Cytomegalovirus Vaccines; Detection; Development; diabetes risk; Disease; environmental agent; Environmental Risk Factor; Etiology; Event; exhaust; Exogenous Factors; Frequencies; Genetic; Genetic Risk; genetic risk factor; Haplotypes; Human; human disease; Hygiene; IA-2-autoantibody; Infection; Insulin-Dependent Diabetes Mellitus; Investigation; islet; Islets of Langerhans; Kinetics; Longitudinal Studies; Measurement; Measures; Mediating; Microbiology; microbiome; Monozygotic twins; Nutrient; Pathway interactions; pre-clinical; preclinical development; prevent; Prevention; Process; prospective; PTPN22 gene; Reagent; Reporting; response; Risk; Role; Sampling; seroconversion; seropositive; Siblings; Specificity; Sunlight; T-Lymphocyte; Testing; TNFRSF10A gene; vaccine trial; Variant; Viral; Viral Proteins; Virus; Virus Diseases; Virus Replication; Work; ","CMV responses in autoantibody positive subjects advocate antiviral treatments for prevention of T1D","150274","","","","S1","01","103111","54133","157244",""
"9964684","U54","CA","5","N","05/18/2020","05/01/2020","04/30/2021","","U54CA209988","","RFA-CA-15-014","5U54CA209988-04","NCI:461333\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","1943901; ","GRAY, JOE W.;","","","","3-Dimensional; Affect; Aftercare; analytical method; analytical tool; Architecture; base; Behavior; bioprinting; Breast Cancer Cell; cancer cell; Cancer Control; Cell Communication; Cell physiology; Cells; Characteristics; Clinical; Collaborations; Computer Analysis; Custom; Data; Databases; deep learning; Development; Distal; Drug Controls; Drug Interactions; Drug Targeting; Engineering; Epidermal Growth Factor Receptor; epigenomics; ERBB2 gene; Exhibits; experimental study; Exposure to; fluorescence imaging; Fluorescence Microscopy; FRAP1 gene; Genomic Instability; Genomics; Goals; Heterogeneity; human tissue; Image; Image Analysis; Immunofluorescence Immunologic; Individual; JAK1 gene; KDR gene; Lead; learning strategy; Light; Link; Machine Learning; Measures; Mediator of activation protein; MEKs; metabolomics; Metadata; Methods; Modeling; Molecular; nanometer resolution; nanoscale; Nature; outreach; Pathway interactions; Periodicity; Pharmaceutical Preparations; Pharmacology; Phenotype; Primary Neoplasm; Procedures; protein expression; Proteins; Reporting; Resistance; Resistance development; Resolution; response; Scanning Electron Microscopy; SDZ RAD; Signal Transduction; Specimen; Stains; System; Techniques; Testing; Therapeutic; Three-dimensional analysis; Tissues; treatment response; triple-negative invasive breast carcinoma; tumor microenvironment; Work; Xenograft procedure; ","Understanding the Impact of Microscale and Nanoscale Heterogeneity and Resistance","209988","ZCA1","Special Emphasis Panel ","8360","","04","324743","136590","","461333"
"9980198","R01","GM","5","N","05/21/2020","03/01/2020","02/28/2021","859","R01GM121565","SCHOOLS OF MEDICINE","PA-13-302","5R01GM121565-04","NIGMS:489195\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","STANFORD","UNITED STATES","MICROBIOLOGY/IMMUN/VIROLOGY","18","009214214","US","8046501","STANFORD UNIVERSITY","CA","943052004","PROJECT NARRATIVE The epidemic of obesity in highly developed countries and health costs for obesity- linked morbidity calls for deeper understanding of the driver mechanisms. Obesity is a complex, oligogenic disease and ciliary signaling mechanisms are central to feeding control in central nervous system. Using proteomics and cell biology, this proposal will work to reduce feeding control to definitive cell biological models, allowing progress and definitive models for drug discovery.","1883005; ","JACKSON, PETER KENT;","AINSZTEIN, ALEXANDRA M","03/01/2017","02/28/2021","Adenylate Cyclase; Affect; Affinity Chromatography; Ankyrin Repeat; Apical; appendage; Architecture; Bardet-Biedl Syndrome; base; Binding; Biochemical; Biological Models; Brain; Calcium; Calcium Signaling; Carrier Proteins; Cell Cycle; Cells; Cellular biology; Centrioles; Cilia; ciliopathy; Complex; Cyclic AMP; Defect; Developed Countries; Disease; Distal; drug discovery; Drug Modelings; Family; feeding; Feeding behaviors; FREQ gene; Froehlich's Syndrome; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; gene product; Genes; Genetic Transcription; Goals; Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Health Care Costs; Homologous Protein; Human; human disease; Human Genetics; human subject; Hyperphagia; Hypothalamic structure; in vivo; insight; Kidney Diseases; kinetosome; Knockout Mice; Leptin; Lesion; Link; link protein; lipid biosynthesis; Mass Spectrum Analysis; Metabolic; Metabolism; Modeling; Molecular; Molecular Analysis; Morbidity - disease rate; mouse model; Neuraxis; Neurons; neuropeptide Y; novel; Obesity; Obesity Epidemic; obesity genetics; Pathway Analysis; Pathway interactions; patient population; Patients; Peripheral; Pilot Projects; Positioning Attribute; Proteins; Proteomics; Radial; receptor; recruit; Regulation; Retinal Degeneration; Role; scaffold; sensor; Sensory; Signal Pathway; Signal Transduction; Signaling Protein; Site; Structure; Syndrome; Testing; Tissues; trafficking; Work; ","Ciliary trafficking mechanisms underlying the human genetics of obesity","121565","NCSD","Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section ","","","04","310771","178424","489195",""
"9918111","P30","ES","1","N","05/21/2020","05/22/2020","03/31/2021","113","P30ES030284","SCHOOLS OF MEDICINE","RFA-ES-18-003","1P30ES030284-01A1","NIEHS:1212256\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","SAN FRANCISCO","UNITED STATES","OBSTETRICS & GYNECOLOGY","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","The overall goal of the proposed UCSF Environmental Research and Translation for Health Center (EaRTH Center) is to accelerate the pace of recognizing and preventing environmental exposures that affect reproduction and development, to improve health across the lifespan. We will offer focused resources to provide expertise and state-of-the-art technologies to create and support new research directions in environmental health at UCSF that are not currently possible. Our research will be tightly integrated with our community engagement, which will embed environmental health within the health care community. Our integrated Center will lead to new scientific understandings in environmental health, which will shift the fundamental understanding of the role of environment in disease, leading to solutions to preventing harmful exposures and improving health.","9485654; ","WOODRUFF, TRACEY J.;","THOMPSON, CLAUDIA L","05/22/2020","03/31/2025","Address; Affect; Analytical Chemistry; Animal Model; Bioinformatics; Biological; Biological Assay; Biomedical Research; California; career; Cell model; Cell Nucleus; Chemical Exposure; Chemicals; Child; Chronic Disease; Clinical; Clinical Medicine; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Community Outreach; Complex; Consultations; Core Facility; Data; data integration; Dentistry; Development; Diabetes Mellitus; Discipline; Disease; dissemination research; education resources; Educational Curriculum; Environment; environmental chemical; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiology; Exposure to; Family; Funding; Future; Goals; Health; health data; health literacy; Health Professional; Health Sciences; Healthcare; healthcare community; high throughput screening; Human; human tissue; improved; in vivo; Infrastructure; insight; Institution; interdisciplinary collaboration; International; Intervention; Investigation; Laboratories; Leadership; Link; Location; Longevity; Malignant Neoplasms; Measurement; Measures; Mediating; Medical; Medical Students; Medicine; member; men; Mentors; Mentorship; Modeling; National Institute of Environmental Health Sciences; Neurodevelopmental Disorder; next generation; Obesity; operation; outreach; Pathway interactions; Patients; Peer Review; Pharmacy facility; Pilot Projects; Planet Earth; Positioning Attribute; Prevalence; prevent; Prevention; Prevention education; Production; programs; Proteomics; Publishing; ranpirnase; Reproduction; reproductive; Reproductive Health; Research; Research Design; Research Personnel; Resources; Role; San Francisco; School Nursing; Schools; Science; Scientist; social; stressor; Students; Technology; tool; Training; Translating; Translational Research; Translations; Underserved Population; Universities; Vulnerable Populations; Women's Health; Work; ","UCSF Environmental Research and Translation for Health Center (EaRTH Center)","030284","EHS","Environmental Health Sciences Review Committee ","","A1","01","773918","438338","1212256",""
"9868860","P01","AG","5","N","05/18/2020","03/01/2020","02/28/2021","","P01AG009524","","PAR-13-258","5P01AG009524-25","NIA:357106\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","TAMPA","UNITED STATES","","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","PUBLIC HEALTH RELEVANCE NARRATIVE- Administrative Core Presbycusis, or Age -Related Hearing Loss (ARHL), is the number one communication disorder and number one neurodegenerative condition of our expanding aging population; and comprises one of the top 3 chronic medical conditions, along with arthritis and cardiovascular diseases. The vast majority of people over age 60 are affected by this progressive decline in auditory sensitivity and speech understanding, which are hallmarks of ARHL. Despite this high prevalence of ARHL, there currently are no medical treatments for preventing or reversing permanent hearing loss (ARHL or other types). The thematic focus of this proposal is modulation of presbycusis through biotherapeutics and acoustic treatments. If the experiments proposed here to test hypotheses concerning interventions to modulate the progression of presbycusis are successful, the novel results should lead to clinical trials of the efficacy of these innovative technological, acoustic and drug-related treatments.","1878841; ","FRISINA, ROBERT D;","","","","Accountability; Acoustics; Administrative Coordination; Administrator; Affect; Age; aged; aging auditory system; aging population; Animals; Annual Reports; Arthritis; Audiology; Auditory; Back; base; Behavior; Biological Response Modifier Therapy; Budgets; Cardiovascular Diseases; Chronic; Clinical Trials; Communication; Communication impairment; comparative; Data; data management; data sharing; Databases; design; Discipline; Effectiveness; efficacy trial; Ensure; Exercise; Expenditure; experimental study; Future; Goals; Grant; Hearing; Hearing Aids; hearing impairment; High Prevalence; Human; Human Resources; human subject; Individual; innovation; Institutional Policy; instrument; Intervention; Investigation; Joints; Lead; Manuscripts; Medical; meetings; member; middle age; Molecular; Monitor; Nerve Degeneration; Neurosciences; normal hearing; novel; Otolaryngology; payment; Peer Review; permanent hearing loss; Pharmaceutical Preparations; Phase; Policies; power analysis; Preparation; Presbycusis; prevent; Principal Investigator; Process; Productivity; Professional Organizations; programs; Progress Reports; Psychoacoustics; public health relevance; Publications; Publishing; Quality Control; Recommendation; recruit; relating to nervous system; Reporting; Research; Research Personnel; Research Support; Resolution; Resource Sharing; Resources; Sampling; Schedule; Services; Societies; Speech; Statistical Computing; Statistical Data Interpretation; Structure; Testing; Time; United States Public Health Service; Universities; Work; ","AGING AUDITORY SYSTEM: PRESBYCUSIS AND ITS NEURAL BASES","009524","ZAG1","Special Emphasis Panel ","5990","","25","239508","117598","","357106"
"9928129","R01","MH","5","N","05/18/2020","05/01/2020","04/30/2021","242","R01MH119127","SCHOOLS OF SOCIAL WELFARE/WORK","PAR-18-007","5R01MH119127-02","NIMH:657716\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BOISE","UNITED STATES","SOCIAL SCIENCES","02","072995848","US","478201","BOISE STATE UNIVERSITY","ID","837250001","PROJECT NARRATIVE High-impact, evidence-based, digital health technologies, such as measurement-based care (MBC) software applications, can dramatically improve the outcomes of behavioral health service systems for youth on a national scale. However, the implementation and sustainment of MBC in youth service settings is stifled by deficits in effective leadership and the development of organizational social contexts necessary to support MBC implementation and sustainment. This project will test an implementation strategy that can be embedded in real-world settings to increase specific, modifiable, leadership and clinician behaviors that contribute to successful MBC implementation, sustainment, and clinical outcomes for youth. The project will improve youth behavioral health by advancing the integration of high-impact digital health technologies into routine, publicly- funded behavioral health systems.","11307699; ","WILLIAMS, NATHANIEL J.;","PINTELLO, DENISE","06/01/2019","04/30/2023","Accounting; Address; Administrator; Adopted; Age; Algorithms; base; Behavior; behavior change; behavioral health; Big Data; burden of illness; care systems; career; Caring; Child Mental Health; Childhood; Climate; Clinic; Clinical; Clinical Research; Communities; community setting; Computer software; Consultations; Country; Data; Diagnosis; digital; disability; effective intervention; Electronic Health Record; evidence base; Evidence based practice; Exhibits; Expenditure; experience; Feedback; Funding; Health Services; Health system; Health Technology; Impairment; implementation strategy; improved; improved outcome; Income; Infrastructure; Intervention; Investments; Leadership; leadership development; Link; Measurement; Mediating; Medical; Mental disorders; Mental Health; Mental Health Services; Modality; mortality; Motivation; Organizational Change; organizational climate; Outcome; Outpatients; Patient-Focused Outcomes; Patients; Pattern; Personal Satisfaction; Phase; Protocols documentation; Provider; Psychotherapy; Randomized Controlled Trials; randomized trial; Recommendation; Research; Research Personnel; Scientist; Service setting; Services; social; Social Environment; social organization; symptomatic improvement; Symptoms; System; Testing; theories; Time; Training; Training Programs; Treatment outcome; United States National Institutes of Health; Youth; ","Randomized trial of a leadership and organizational change strategy to improve the implementation and sustainment of digital measurement-based care in youth mental health services","119127","DIRH","Dissemination and Implementation Research in Health Study Section ","","","02","542363","115353","657716",""
"9901637","G11","TW","5","N","05/18/2020","04/01/2020","03/31/2021","989","G11TW010936","","PAR-16-280","5G11TW010936-04","FIC:99360\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","NAIROBI","KENYA","","","559368120","KE","10052861","AGA KHAN UNIVERSITY (KENYA)","","00100","NARRATIVE The proposed program will strengthen the research administration and management infrastructure at Aga Khan University East Africa (AKU) to conduct HIV research in Kenya through a collaborative partnership with the University of Washington (UW). The program will build research capacity at AKU by: 1) conducting an assessment of the AKU research administration and management systems in Nairobi, Kenya; 2) implementing workshops in Nairobi and site visits to the UW in Seattle for AKU research administrators and grant managers; and 3) providing online financial management courses and ongoing mentorship from UW program faculty for AKU staff. The proposal will train and mentor 12 AKU trainees in hands-on workshops and mentorship programs, bring 10 trainees from AKU to UW, and teach dozens of trainees through online courses.","8223125; ","CHUNG, MICHAEL HOONBAE;","BANSAL, GEETHA PARTHASARATHY","04/24/2018","03/31/2021","Accountability; Address; Administrator; Africa; AIDS prevention; Applications Grants; Award; base; Cardiology; Caring; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Trials; Communicable Diseases; Country; Department chair; Development; Discipline of Nursing; Disease; Education; Educational workshop; Environment; Epidemic; Epidemiology; Equipment; experience; Faculty; Fellowship; Funding; Funding Agency; global health; Grant; Growth; Guidelines; Health Personnel; HIV; Hospitals; improved; Individual; Infrastructure; infrastructure development; Institution; International; Interview; Kenya; Knowledge; Medical; Medical Research; medical schools; medical specialties; Medicine; meetings; Mentors; Mentorship; mid-career faculty; Occupational activity of managing finances; online course; Persons; Preparation; Procedures; programs; Reporting; Research; Research Infrastructure; Research Institute; Research Support; School Nursing; Series; Site; Site Visit; skills; System; Tanzania; Training; Training Programs; Uganda; United States National Institutes of Health; Universities; University Hospitals; Visit; Washington; Work; ","Infrastructure Development Training Program for Aga Khan University East Africa","010936","ZRG1","Special Emphasis Panel ","","","04","94086","5274","99360",""
"10160208","R01","MH","3","N","05/20/2020","05/05/2020","03/31/2021","242","R01MH106781","SCHOOLS OF MEDICINE","PA-13-302","3R01MH106781-05S1","NIMH:77780\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","LA JOLLA","UNITED STATES","PSYCHIATRY","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","PUBLIC HEALTH RELEVANCE: Anorexia nervosa (AN) is a brain-based disorder that often leads to serious health consequences including death. We recently identified EPHX2 as a susceptibility gene for AN. Using complementary approaches, we will develop multi-domain Omics biomarkers for AN through a food-challenge protocol in order to understand how the protein product of EPHX2 (sEH) contributes to food aversion, psychopathology phenotypes and outcome in AN patients. We will establish the molecular mechanisms by which the EPHX2 gene partners with dietary factors to impact AN. The knowledge gained will enable development of better interventions and treatments.","9827698; ","SHIH, PEI-AN ;","CHAVEZ, MARK","06/21/2016","03/31/2021","Affect; Anorexia Nervosa; Anti-inflammatory; Arachidonic Acids; base; Base of the Brain; Biochemistry; Biological Assay; Biological Markers; Cessation of life; Chronic; Data; design; Development; Diet; Dietary Factors; Disease; Disease Outcome; Disease Progression; disorder risk; Eating; Emaciation; Enzymes; Epoxide hydrolase; Epoxy Compounds; Exposure to; Fasting; Food; Food Aversion; food challenge; Functional disorder; Future; gene product; Genes; Genetic; genetic variant; Glycols; Health; Heritability; improved; in vivo; Inflammation; Inflammatory; innovation; insight; Intake; Intervention; Knowledge; Lead; Link; Lipids; longitudinal design; Measures; Meat; Mental Health; Messenger RNA; Metabolism; metabolomics; Molecular; Monitor; Morbidity - disease rate; mortality; mRNA Expression; multiple omics; non-genetic; Nutraceutical; Omega-3 Fatty Acids; Omega-6 Fatty Acids; Outcome; Pathogenesis; Pathway interactions; Patients; Pharmacologic Substance; Phenotype; Play; Polyunsaturated Fatty Acids; Predisposition; Prevention; Prognostic Marker; Proteins; Protocols documentation; Psychiatry; Psychopathology; Public Health; public health relevance; Recurrence; Relapse; Research Design; Risk; risk variant; Role; Signal Transduction; Susceptibility Gene; System; Testing; therapy development; trait; treatment response; Variant; Weight; Work; ","Solving EPHX2 and PUFA Interactions in Anorexia Nervosa","106781","BGES","Behavioral Genetics and Epidemiology Study Section ","","S1","05","49384","28396","77780",""
"9906180","R01","CA","5","N","05/22/2020","05/01/2020","04/30/2021","396","R01CA217989","SCHOOLS OF MEDICINE","PA-16-160","5R01CA217989-03","NCI:439793\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","PEDIATRICS","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","Project Narrative Involuntary weight loss, anorexia, fatigue, and loss of muscle are common in patients with pancreatic cancer. New research demonstrates that these problems limit quality of life for many patients, and also are a significant contributor to risk of death. Our studies are designed to investigate the ways in which pancreatic cancer leads to these disabling changes in behavior and metabolism to better understand how this might be treated.","1929010; ","MARKS, DANIEL L;","WATSON, JOANNA M","05/10/2018","04/30/2023","Acute; Address; Amplifiers; Animal Model; Anorexia; Attenuated; Automobile Driving; Behavior; Behavioral; Biochemical; Blood - brain barrier anatomy; Body Weight decreased; Brain; Cachexia; cancer cachexia; Cancer Patient; Catabolism; Cause of Death; Cell Culture Techniques; Chronic; Chronic Disease; Clinical Trials; Collaborations; cytokine; Data; design; Desire for food; Development; Disease; effective therapy; Endocrine; exosome; Exposure to; extracellular vesicles; Fatigue; Flow Cytometry; Goals; Hypothalamic structure; improved; In Vitro; in vivo; Individual; Inflammation; Inflammatory; Inflammatory Response; innovation; Intervention; Laboratories; Lead; lean body mass; Lethargies; Leukocytes; Life; Ligands; Link; lipid metabolism; Maintenance; Malignant neoplasm of pancreas; Malnutrition; Mediator of activation protein; Metabolic; Metabolic syndrome; Metabolism; Microglia; MicroRNAs; Modeling; Molecular; Morbidity - disease rate; mortality; mortality risk; Motivation; mouse model; Muscle; Muscular Atrophy; Neuraxis; Neuroendocrinology; neuroinflammation; Neurons; Neurosciences; neurotransmission; novel; novel therapeutics; Organ; pancreatic cancer patients; Pancreatic Ductal Adenocarcinoma; Pathway interactions; Patients; Peripheral; Pharmacologic Substance; Population; Process; Production; Property; Quality of life; recruit; Research; Resources; response; Role; Savings; sensor; Sensory; Severities; Sick Role; Signal Pathway; Signal Transduction; Signaling Molecule; Syndrome; Techniques; Testing; Therapeutic Intervention; therapeutic target; Tissues; TLR7 gene; Toll-like receptors; Treatment Efficacy; tumor; Tumor-Derived; wasting; Work; ","Exosomes as Endocrine Signaling Molecules in Cancer Cachexia","217989","TCB","Tumor Cell Biology Study Section ","","","03","285580","154213","439793",""
"9933099","R01","NS","5","N","05/22/2020","05/01/2020","04/30/2021","853","R01NS082730","SCHOOLS OF MEDICINE","PA-18-484","5R01NS082730-07","NIA:137133\NINDS:646505\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","Chicago","UNITED STATES","ANATOMY/CELL BIOLOGY","07","098987217","US","577703","UNIVERSITY OF ILLINOIS AT CHICAGO","IL","606124305","Alzheimer?s disease and most Alzheimer?s disease related dementias are classified as tauopathies, because they exhibit with misfolded tau protein that is highly phosphorylated. However, these tauopathies may differ in the neuronal population affected as well as the isoform composition and structure of tau aggregates involved. Our previous studies suggest that mIsfolding of tau may lead to dysregulation of a normal biological function of tau. Studies in this application characterize the normal function of tau, evaluate the toxicity of disease-specific conformations for pathological tau and examine the possibility that tau acts as a scaffold for signaling pathways in the neuron which can affect axonal transport and other neuronal functions.","6621556 (contact); 7055481; ","BRADY, SCOTT THOMAS (contact); KANAAN, NICHOLAS M;","MCGAVERN, LINDA","04/15/2014","04/30/2024","Acetylation; Address; Adult; Affect; Alzheimer's Disease; Alzheimer's disease related dementia; Amino Acids; Antibodies; Axon; Axonal Transport; base; Binding; Biological; Biological Process; Biology; Brain; Brain Diseases; Chromosome 17; chronic traumatic encephalopathy; Clinical; clinical phenotype; corticobasal degeneration; Cytomegalovirus Infections; Development; Disease; Elements; Embryo; Exhibits; Exons; experimental study; fast axonal transport; Foundations; Frontotemporal Dementia; FTD with parkinsonism; Funding; Generations; Genes; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Health; Histologic; immunoreactivity; Impairment; Knowledge; Lead; Link; Microtubules; Modification; Molecular; Molecular Conformation; Morphology; Mutation; nervous system disorder; Neurodegenerative Disorders; neuron development; Neurons; neurotransmission; novel; Pathogenesis; Pathogenicity; Pathologic; Pathology; Patients; Pattern; Peripheral Nerves; Phenotype; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiological; Pick Disease of the Brain; Play; Population; Post-Translational Protein Processing; Progressive Supranuclear Palsy; Protein Isoforms; Protein phosphatase; Proteins; Regulation; RNA Splicing; Role; scaffold; Signal Pathway; Signal Transduction; Site; Structure; Synapses; tau aggregation; tau conformation; tau function; tau mutation; tau phosphorylation; tau Proteins; Tauopathies; Testing; Toxic effect; Variant; Work; ","Tau Conformation in Tauopathies and Neuronal Function","082730","ZRG1","Special Emphasis Panel ","","","07","625724","157914","783638",""
"10158197","U54","EB","3","N","05/22/2020","05/22/2020","05/21/2021","286","U54EB027690","SCHOOLS OF MEDICINE","PA-18-591","3U54EB027690-02S1","NIBIB:31080737\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","ATLANTA","UNITED STATES","PEDIATRICS","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","Project Narrative Intentionally Left Blank","8855102; 7889281 (contact); 3104533; ","BRAND, OLIVER ; LAM, WILBUR A (contact); MARTIN, GREGORY S;","LASH, TIFFANI BAILEY","05/22/2020","05/21/2021","American; Biomedical Engineering; Child health care; Clinical; Clinical Research; Collaborations; commercialization; COVID-19; Development; Device or Instrument Development; Diagnostic; Diagnostic tests; Doctor of Philosophy; Electronics; Emergency Situation; Engineering; Equilibrium; Fostering; Funding; Head; Hematologist; innovation; Institutes; International; Leadership; Left; Medical Device; Microfluidics; microsystems; Nanotechnology; Pediatric Hospitals; point of care; Population; programs; prototype; Recording of previous events; Running; Schools; Side; System; United States National Institutes of Health; University Hospitals; Validation; Work; ","Emergency COVID-19 supplement for Atlanta Center for Microsystems Engineered Point-of-Care Technoloites (ACME POCT)","027690","","","","S1","02","21598976","9481761","31080737",""
"10056053","R01","MH","3","N","05/18/2020","03/01/2020","10/31/2020","242","R01MH116882","SCHOOLS OF MEDICINE","PA-18-906","3R01MH116882-02S1","NIMH:58709\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","DALLAS","UNITED STATES","NEUROLOGY","30","800771545","US","578404","UT SOUTHWESTERN MEDICAL CENTER","TX","753909105","Project Narrative Despite its significant health care burden, no targeted therapies are available for the treatment of autism spectrum disorders, as the mechanisms underlying these disorders remain poorly understood. In this proposal, we will not only delineate neural circuit mechanisms that underlie these disorders but also delineate the benefit of neural circuit modulation for the treatment of these devastating disorders.","11145671; ","TSAI, PETER T.;","VICENTIC, ALEKSANDRA","03/01/2020","10/31/2023","Address; Adult; Affect; Anatomy; autism spectrum disorder; base; Behavior; Behavior Disorders; Behavioral; behavioral study; Brain; care burden; Cell Culture Techniques; Cerebellar Diseases; Cerebellum; Child; Clinical; Clinical Research; critical developmental period; critical period; Data; Decision Making; Deep Brain Stimulation; Defect; defined contribution; Development; Disease; Early treatment; effective therapy; Electrophysiology (science); experimental study; Genes; Genetic; genetic manipulation; Healthcare; Impairment; improved; in vivo; in vivo Model; Intervention; Lifestyle-related condition; Light; Literature; Medial; Mediating; mouse model; Mus; mutant; Nature; neural circuit; Neurodevelopmental Disorder; neuroregulation; Nuclear; optogenetics; Pathogenesis; Pharmacology; Phenotype; Physiology; postnatal; pre-clinical; Prefrontal Cortex; prevent; Publishing; Purkinje Cells; Regulation; Role; Signal Transduction; Slice; Social Behavior; targeted treatment; Techniques; Thalamic structure; Therapeutic; therapeutic development; Therapeutic Uses; Time; treatment duration; treatment strategy; Tuberous Sclerosis; Viral; Work; ","Cerebellar-cerebro cortical circuits in ASD","116882","","","","S1","02","35990","22719","58709",""
"9924653","P20","NR","5","N","05/22/2020","05/01/2020","04/30/2021","","P20NR016599","","RFA-NR-16-001","5P20NR016599-05","NINR:40636\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","HADLEY","UNITED STATES","","02","153926712","US","850904","UNIVERSITY OF MASSACHUSETTS AMHERST","MA","010359450","","9756070; ","MARQUARD, JENNA LOUISE;","","","","Address; Affect; American; Area; Awareness; Chronic; Communities; Complex; design; Development; Discipline; Educational Materials; Educational workshop; Engineering; Ensure; Environment; Evaluation; Evaluation Reports; experience; Family; Fatigue; Funding; Goals; Home environment; Human; improved; Individual; informal caregiver; insight; Insurance; interest; Intervention; Journals; Life; Light; Medical Informatics; meetings; member; Methods; Monitor; Noise; Outcome; patient oriented; patient safety; Patients; Pattern; Persons; Pilot Projects; Process; prototype; Public Health Informatics; Publications; Quality of life; Regulation; Research Personnel; Research Project Grants; Role; Schedule; Services; Sleep disturbances; Solid; symposium; symptom science; symptom self management; Symptoms; System; technological innovation; Technology; Testing; Time Factors; tool; Work; ","UManage Human Factors Core","016599","ZNR1","Special Emphasis Panel ","5301","","05","32395","19749","","40636"
"9978443","R21","AA","1","N","05/18/2020","05/20/2020","04/30/2021","273","R21AA027858","SCHOOLS OF MEDICINE","PA-19-053","1R21AA027858-01A1","NIAAA:242326\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM","","FARMINGTON","UNITED STATES","INTERNAL MEDICINE/MEDICINE","05","022254226","US","1506603","UNIVERSITY OF CONNECTICUT SCH OF MED/DNT","CT","060305335","Public relevance Alcohol use disorder is associated with tremendous medical, social, and economic consequences. This serious public health problem calls for better understanding of the etiology of AUD and development of novel preventive and therapeutic approaches. Our proposal studying the gut microbiome as a non-genetic factor in influencing alcohol intake and its potential mechanism may point to a novel microbiome biomarker for identification of risk population, as well as modifiable targets (microbiome) for novel therapeutics of AUD.","11316117; ","ZHOU, YANJIAO ;","GRAKALIC, IVANA","05/20/2020","04/30/2022","Acetylation; Acute; Affect; alcohol abuse therapy; Alcohol consumption; alcohol exposure; alcohol measurement; alcohol use disorder; Alcohols; Amygdaloid structure; Antibiotics; Attention; Bacteria; Behavior; Biological Markers; biomarker identification; Biotin; Blood; Blood - brain barrier anatomy; Brain; Brain Diseases; brain tissue; Butyrates; Chromatin; Chromatin Structure; Chronic; chronic alcohol ingestion; Colon; Controlled Environment; data reduction; Development; Disease; drinking; drinking behavior; drinking water; dysbiosis; Economics; Environment; Epigenetic Process; epigenetic regulation; epigenome; Ethanol; Etiology; experimental study; fecal transplantation; Feces; Fermentation; Gene Expression; Gene Expression Regulation; Genes; Genetic; Genetic Transcription; Genomics; Goals; gut microbes; gut microbiome; Health; Heavy Drinking; Histone Deacetylase Inhibitor; histone modification; Immune; improved; Individual; individual variation; insight; Linear Regressions; Mass Spectrum Analysis; Measures; Mediating; Medical; metagenomic sequencing; Microbe; microbial; microbiome; microbiome analysis; microbiota; Modification; Molecular; Mus; Neurons; neurophysiology; Neuropsychology; non-genetic; novel; novel therapeutics; Oral Administration; Pathway interactions; Phenotype; Physiological Processes; Population; prebiotics; Predisposition; preference; Prefrontal Cortex; Prevention; Prevention strategy; Preventive; Property; Public Health; Rattus; Regulation; Risk; Role; Sample Size; sex; social; Testing; Therapeutic; transcriptome; Transplant Recipients; Transplantation; Variant; Vitamins; Volatile Fatty Acids; Work; ","The role of the gut microbiome as a non-genetic factor in influencing excessive alcohol drinking.","027858","AA","National Institute on Alcohol Abuse and Alcoholism Initial Review Group ","","A1","01","147760","94566","242326",""
"10058143","R03","MH","1","N","05/19/2020","05/20/2020","05/19/2022","242","R03MH120627","SCHOOLS OF ARTS AND SCIENCES","PA-19-052","1R03MH120627-01A1","NIMH:152385\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","ARLINGTON","UNITED STATES","BIOSTATISTICS & OTHER MATH SCI","06","064234610","US","578402","UNIVERSITY OF TEXAS ARLINGTON","TX","760190145","Narrative In this project, we develop novel computational methods for brain structure variability studies. The methods are based on Jacobian determinants and curl vectors, which completely characterize deformations that arise from these studies. The successful completion of the project will significantly enhance our ability to diagnose, monitor, and treat brain diseases and mental disorder.","9646826; ","LIAO, GUOJUN GORDON;","ZHAN, MING","05/20/2020","05/19/2022","3-Dimensional; Algorithm Design; Alzheimer's Disease; Area; base; Biological; Brain; Brain Diseases; Brain imaging; Computational Technique; computer code; computer science; Computer software; computerized tools; Computing Methodologies; Data; Development; Diagnosis; doctoral student; Effectiveness; Future; Goals; Image; Image Analysis; image registration; imaging modality; improved; innovation; Magnetic Resonance Imaging; mathematical sciences; Medical Imaging; Mental disorders; Methodology; Methods; Modeling; Monitor; morphometry; novel; novel strategies; Positioning Attribute; preservation; Prize; Process; Research; Research Personnel; Rotation; Sampling; Science; Shapes; Structure; Techniques; Technology; Testing; Tissues; Training; Variant; vector; ","Novel Construction of Unbiased Templates for Brain Morphometry","120627","EITN","Emerging Imaging Technologies in Neuroscience Study Section ","","A1","01","100000","52385","152385",""
"9729528","R01","AR","5","N","05/21/2020","05/01/2020","04/30/2021","846","R01AR069010","SCHOOLS OF MEDICINE","PA-13-302","5R01AR069010-04","NIAMS:334400\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","MEMPHIS","UNITED STATES","PEDIATRICS","09","941884009","US","578302","UNIVERSITY OF TENNESSEE HEALTH SCI CTR","TN","381034903","The significance of the proposed work lies with the parallel use of animal models of arthritis to study a new treatment strategy for RA. In this application, we plan to use two murine models of arthritis to study the mechanism by which new safer hydroxyderivatives of vitamin D3 can upregulate an inhibitory receptor to suppress unwanted inflammatory responses in autoimmune arthritis. The purpose of the proposal is to delineate the mechanism of action by which autoimmunity is suppressed with the ultimate aim of developing safer and more effective treatments for RA.","6405826; ","YI, AE-KYUNG ;","MAO, SU-YAU","05/13/2016","04/30/2022","Affect; analog; Animal Model; Antibodies; Arthritis; Attenuated; attenuation; autoimmune arthritis; Autoimmune Process; Autoimmunity; base; Biochemical; Biological Response Modifiers; CD3 Antigens; CD4 Positive T Lymphocytes; Cell Lineage; Cell physiology; Cells; Cholecalciferol; Collagen; Collagen-Induced Arthritis; cytokine; Cytokine Suppression; Cytoplasmic Tail; Data; delta opioid receptor; Disease; DR1 gene; effective therapy; Etiology; Event; experimental study; Flow Cytometry; FOXP3 gene; Harvest; Histologic; Immune; Immunization; Immunize; Immunoglobulins; in vivo; Inflammation; Inflammatory; Inflammatory Response; Interferon Type II; Interleukin-1 Receptors; Interleukin-10; Interleukin-17; Interleukin-4; Joints; Lead; leukocyte activation; Leukocytes; Ligands; lymph nodes; MAP Kinase Gene; Measures; Mediating; Methods; Modeling; Molecular; Monoclonal Antibodies; mouse model; Mus; novel; Pathway interactions; Patients; Prevention; Production; PTPN6 gene; receptor; Receptor Cell; Receptor Signaling; recruit; Regulation; Reporter; response; Rheumatoid Arthritis; Role; Severities; Signal Pathway; Signal Transduction; Spleen; Stains; T cell response; T-Lymphocyte; T-Lymphocyte Subsets; Testing; transcription factor; treatment strategy; Tyrosine; Up-Regulation; Vitamin D; Vitamin D Analog; Work; ","Inhibitory Receptors and  Autoimmune Arthritis","069010","ACTS","Arthritis, Connective Tissue and Skin Study Section ","","","04","220000","114400","334400",""
"9970981","R01","DK","1","N","05/19/2020","05/19/2020","02/28/2021","847","R01DK121824","SCHOOLS OF MEDICINE","PA-19-056","1R01DK121824-01A1","NIDDK:367499\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","BALTIMORE","UNITED STATES","SURGERY","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Project Narrative. Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in premature infants, and for which there exists no effective cure. The current proposal seeks to understand the causes of NEC by focusing on how derangements in the enteric nervous system ? which serves to regulate many aspects of intestinal function ? can lead to the development of this disease, and to identify novel agents which when added to the diet to enhance the enteric nervous system can prevent NEC in premature infants.","6874851; ","HACKAM, DAVID J;","HAMILTON, FRANK A","05/19/2020","02/29/2024","Agonist; analog; Apoptosis; Bacteria; base; Brain-Derived Neurotrophic Factor; Cause of Death; Child; Data; design; Development; Diet; Disease; Enteral; Enteric Nervous System; Epithelial; Epithelium; Family; Gastrointestinal Diseases; Glial Fibrillary Acidic Protein; Goals; Human; in utero; Infant; Inflammation; Inflammatory Response; Injections; intestinal epithelium; Intestines; Knock-out; Lead; Libraries; Link; Lipopolysaccharides; Mus; Necrotizing Enterocolitis; Neuroglia; Neurons; Newborn Infant; novel; novel therapeutic intervention; Pathogenesis; Pathway interactions; Play; premature; Premature Birth; Premature Infant; prevent; Prevention; Prevention strategy; protective effect; receptor; Receptor Activation; Regulation; release factor; Role; Safety; Severities; Signal Transduction; Testing; Thinking; TLR4 gene; treatment strategy; Up-Regulation; ","Enteric Glia Regulation of Intestinal Epithelial TLR4 Signaling In Necrotizing Enterocolitis","121824","GMPB","Gastrointestinal Mucosal Pathobiology Study Section ","","A1","01","237162","130337","367499",""
"9979976","R21","MH","5","N","05/18/2020","05/01/2020","04/30/2021","242","R21MH118489","SCHOOLS OF MEDICINE","PA-18-350","5R21MH118489-02","NIMH:243000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PHILADELPHIA","UNITED STATES","PSYCHIATRY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Program Director/Principal Investigator (Last, First, Middle): Pellecchia, Melanie & Mandell, David Samuel PROJECT NARRATIVE The goal of the proposed R21 is to develop and pilot test a toolkit of implementation strategies that increase early intervention providers' use of evidence-based parent coaching techniques for families of young children with or at risk for autism spectrum disorder. This project will use a community-partnered participatory research design to develop an implementation toolkit that incorporates identified psychological and organizational constructs that influence providers' use of parent coaching. These activities will lay the foundation for an R01 to evaluate the effectiveness of this toolkit in a later randomized community trial. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page","2053526; 12049206 (contact); ","MANDELL, DAVID S; PELLECCHIA, MELANIE  (contact);","PINTELLO, DENISE","07/17/2019","04/30/2021","Address; Adult; Affect; Application procedure; Attention; Attitude; autism spectrum disorder; autistic children; base; Behavior; behavior change; Behavioral; Belief; Child; Communities; community setting; Community Trial; Conflict (Psychology); design; Development; Early Intervention; Effectiveness; Environmental Risk Factor; evidence base; Exhibits; expectation; Family; Feedback; field study; Foundations; Funding; Goals; Grant; Guidelines; implementation strategy; improved; innovation; interest; Intervention; Interview; Leadership; Learning; Measurement; Measures; Mediating; Methods; Modeling; Motivation; novel; novel strategies; organizational climate; Organizational Culture; Outcome; Parents; patient oriented; pedagogy; Philadelphia; Planning Theory; Play; Principal Investigator; Procedures; Process; programs; prototype; Provider; provider intervention; psychologic; Qualitative Methods; Randomized; randomized trial; Request for Applications; Research Design; Research Institute; Research Methodology; Risk; Role; Sampling; Self Efficacy; Services; Structure; Surveys; symptom treatment; System; Techniques; Testing; theories; Time; Training; ","Exploring and Developing Implementation Strategies to Support Parent Coaching","118489","ZMH1","Special Emphasis Panel ","","","02","150000","93000","243000",""
"10168709","R25","MH","3","N","05/22/2020","04/14/2020","03/31/2021","242","R25MH094612","","PAR-14-306","3R25MH094612-09S1","NIMH:15120\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","Project Narrative In 2007, the Massachusetts General Hospital (MGH) and McLean Hospital piloted an integrated Research Concentration within the MGH/McLean Adult Psychiatry Residency Training Program to address the critical shortage of physician-scientists engaged in mental health research careers. This now established program has been highly successful through its first federally funded period. This competitive renewal application will provide support and infrastructure to continue, improve, and expand this well-integrated research education program that serves to attract and train residents to become future psychiatrist-scientists in basic, translational, and patient-oriented research, while increasing research literacy among all psychiatry residents.","1882325 (contact); 1869054; ","FAVA, MAURIZIO  (contact); GREENFIELD, SHELLY F.;","CHAVEZ, MARK","06/01/2011","03/31/2022","ABCB1 gene; Address; Adult; Basic Science; Behavior; Big Data; Bioinformatics; Biomedical Research; career; catalyst; Center for Translational Science Activities; Clinical; clinical practice; Clinical Research; Clinical Sciences; Clinical Trials; cognitive neuroscience; cognitive system; Complex; Data; design; Development; Disease; Doctor of Philosophy; education research; education resources; Educational Curriculum; Educational workshop; effectiveness research; Electroencephalography; Enrollment; Evaluation; experience; Exposure to; faculty research; Fellowship; Financial Support; Formulation; Fostering; Funding; Future; General Hospitals; genome wide association study; Genomics; Goals; Grant; Health; health care delivery; Health Professional; Health Services Research; Healthcare; Hospital Departments; Hospitals; Human; improved; Infrastructure; Institution; interest; K-Series Research Career Programs; Knowledge; Leadership; literacy; Massachusetts; medical schools; Medical Students; member; Mental Health; Mentorship; Molecular and Cellular Biology; National Institute of Mental Health; neural circuit; neuroimaging; Neurophysiology - biologic function; Neurosciences; next generation; patient oriented; patient oriented research; Periodicity; Physicians; Program Evaluation; Program Reviews; programs; Psychiatrist; Psychiatry; Recommendation; recruit; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Research Training; Residencies; response; Rotation; Scientist; Secure; Seeds; skills; Structure; success; Talents; Time; Training; Training Programs; translational neuroscience; Translational Research; United States National Institutes of Health; Work; Writing; ","Fostering Research Mentorship and Training During Psychiatry Residency","094612","ZMH1","Special Emphasis Panel ","","S1","09","14000","1120","15120",""
"10124496","K23","AI","3","N","05/20/2020","05/20/2020","08/31/2020","855","K23AI143967","SCHOOLS OF MEDICINE","PA-18-591","3K23AI143967-01S1","NIAID:49756\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","Aurora","UNITED STATES","PEDIATRICS","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","PROJECT NARRATIVE Studies evaluating the clinical and economic outcomes of COVID-19 will be critical in understanding the burden of disease in high-risk populations, such as adults with chronic medical conditions, and in helping policymakers make informed decisions about implementing preventive strategies. We aim to add SARS-CoV-2 RT-PCR testing to an existing NIAID-funded study evaluating clinical and economic outcomes of influenza and other respiratory pathogens in Guatemalan agricultural workers. This Administrative Supplement is necessary to cover the additional costs of an expected increase in cough/fever (SARI) cases within our existing surveillance system as well as SARS-CoV-2 testing.","9825287; ","OLSON, DANIEL ;","COOPER, MICHAEL JOHN","05/20/2020","08/31/2022","2019-nCoV; Absenteeism; Accounting; Acute; Acute Kidney Failure; Acute respiratory infection; Administrative Supplement; Admission activity; Adult; Agricultural Workers; Agriculture; Area; Banana; base; Berlin; biobank; Biological Assay; Biological Markers; Blood; Blood Urea Nitrogen; burden of illness; Chronic; Chronic Kidney Failure; Clinical; cohort; Colorado; Communities; Consent; cost; Cost of Illness; cost outcomes; Coughing; COVID-19; Creatinine; Data; Disease; Economic Burden; economic impact; economic outcome; Economics; Enrollment; Epidemiology; Facilities and Administrative Costs; Fever; flu; follow-up; Funding; Glycosylated hemoglobin A; Guatemala; Guatemalan; Health system; high risk population; Hospitalization; Hospitals; Household; Human Development; Human Resources; Incidence; Infection; Influenza; Influenza A virus; Injury to Kidney; Kidney Diseases; Labor Forces; Linear Regressions; Link; low and middle-income countries; Measures; Medical; meetings; Mentors; Mesoamerican; mortality; National Institute of Allergy and Infectious Disease; Natural History; Outcome; palm oil; Parents; pathogen; Population; population based; post gamma-globulins; Prevalence; Prevention strategy; Production; Productivity; prospective; Prospective cohort; Protocols documentation; Public Health; Reporting; Research; Resources; respiratory; Respiratory Tract Infections; Reverse Transcriptase Polymerase Chain Reaction; Risk; Sampling; SARS coronavirus; Serum; Severities; Severity of illness; Site; socioeconomics; Specimen; Surveys; System; Testing; Universities; Urine; Vaccination; Viral; Virus; Visit; Wages; ","Predictors of Influenza-Associated Absenteeism and Impact of Vaccination in a Cohort of Guatemalan Agricultural Workers","143967","","","","S1","01","46272","3484","49756",""
"10124477","R44","AI","4","N","05/19/2020","05/19/2020","04/30/2021","855","R44AI145491","","PA-18-574","4R44AI145491-02","NIAID:886103\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","Juno Beach","UNITED STATES","","18","079628064","US","10038098","EMMUNE, INC","FL","33408","PROJECT NARRATIVE eCD4-Ig is an exceptional HIV-1 entry inhibitor that may help prevent new HIV-1 infections and maintain a drug-free state of HIV-1 remission in infected persons. Here we will extend its half-life, increase its neutralization potency, and reduce its immunogenicity, thereby improving its safety, efficacy, and cost.","12543320; 9292097 (contact); ","ALPERT, MICHAEL DAVID; BAILEY, CHARLES CORBIN (contact);","CONLEY, TONY J","05/19/2020","04/30/2023","Address; adeno-associated viral vector; Animals; Antibodies; antibody-dependent cell cytotoxicity; antiretroviral therapy; C-terminal; CCR5 gene; Cell Culture Techniques; cost; Data; Dependovirus; Disease remission; Dose; Drug Kinetics; Epitopes; Exhibits; Fc domain; fight against; fitness; Generations; Goals; Half-Life; HIV-1; HIV-2; Human; immunogenic; immunogenicity; Immunoglobulin G; improved; in vivo; Individual; Infection; inhibitor/antagonist; Lead; lead candidate; Light; Macaca; Macaca mulatta; mimetics; Mutation; neutralizing antibody; pandemic disease; Patients; Peptides; peptidomimetics; Persons; Pharmaceutical Preparations; Phase; prevent; Production; Property; Prophylactic treatment; Proteins; Proteome; receptor; Residual state; Resistance; Rodent Model; Safety; screening; Series; Serum; simian human immunodeficiency virus; SIV; synergism; Testing; Therapeutic; tool; Toxic effect; Toxicology; Transgenes; tyrosine O-sulfate; Vaccines; Variant; Viral; viral rebound; Viral reservoir; virology; Virus; ","Improving the pharmacokinetics, potency, and immunogenicity of eCD4-Ig","145491","ZRG1","Special Emphasis Panel ","","","02","","","886103",""
"9937164","P01","AG","2","N","05/22/2020","04/01/2020","03/31/2021","","P01AG002132","","PAR-18-297","2P01AG002132-39","NIA:403543\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","1883014; ","DEGRADO, WILLIAM F;","","","","abeta oligomer; Aging; Alleles; Alzheimer's Disease; Alzheimer's disease risk; Amyloid; Amyloid beta-Protein; amyloid structure; Animal Model; Animals; Apolipoprotein E; Binding; Biological Assay; Blood Vessels; Brain; Brain Diseases; Cell Culture Techniques; Cell Line; Cell model; Cells; Cerebral Amyloid Angiopathy; Characteristics; Clinical; Collaborations; Complex; crosslink; Cryoelectron Microscopy; Development; Disease; Disease Progression; Down Syndrome; Drug Screening; Environmental Risk Factor; Extracellular Domain; Fingerprint; Fluorescence Microscopy; Fluorescent Dyes; Genetic Diseases; genetic risk factor; Grain; Human; imaging agent; improved; In Vitro; in vivo; in vivo Model; Mass Spectrum Analysis; Membrane Proteins; Methods; Modeling; Molecular; Molecular Conformation; mouse model; Mus; mutant; Neurodegenerative Disorders; Neurons; new therapeutic target; Patients; Prion Diseases; Prions; programs; Protein Isoforms; Proteins; Proteolysis; PrP; rapid technique; response; Risk Factors; Sampling; Seeds; Senile Plaques; Signal Transduction; Slice; solid state nuclear magnetic resonance; Structural Models; Structure; Surface; System; tau conformation; tau Proteins; Tauopathies; Therapeutic Agents; Therapeutic Intervention; Tissue Sample; Tissues; Transgenic Mice; Transmembrane Domain; transmission process; TREM2 gene; TYROBP gene; Variant; ","Project 2: Conformation and propagation of misfolded forms of tau and Abeta","002132","ZAG1","Special Emphasis Panel ","6195","","39","250000","153543","","403543"
"10148143","U54","EB","3","N","05/22/2020","05/22/2020","05/21/2021","286","U54EB007958","SCHOOLS OF MEDICINE","PAR-17-453","3U54EB007958-12S1","NIBIB:1630349\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","BALTIMORE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Narrative Overall Component The relevance of this project to public health is that by use of Point-of Care tests to rapidly and accurately diagnose sexually transmitted diseases (STDs), the sexual health of individuals in both the U.S. and in resource poor settings throughout the world will be improved. Rapid diagnosis and prompt treatment will improve sexual health in the world and prevent the spread of these infectious diseases, by changing behavior and adding to the sexual wellbeing of individuals.","2089185; ","MANABE, YUKARI C;","LASH, TIFFANI BAILEY","05/22/2020","05/21/2021","accurate diagnosis; Address; Algorithms; Anxiety; Back; Bedside Testings; behavior change; Behavioral; Biological Assay; Care Technology Points; Centers for Disease Control and Prevention (U.S.); Chlamydia; Clinical; Clinical assessments; clinical translation; commercialization; Communicable Diseases; Congenital Syphilis; Counseling; Country; Data; design; Development; Diagnosis; Diagnostic; Direct Costs; Disease; Education; Emerging Technologies; Engineering; Ensure; Epidemic; Facilities and Administrative Costs; Funding; Goals; Gonorrhea; Health; health disparity; Healthcare; Healthcare Systems; HIV; Home environment; improved; Income; indicated prevention; Individual; Infection; Lead; Medical Device; member; Mental Depression; Modeling; Needs Assessment; new technology; Newborn Infant; Patients; Personal Satisfaction; point of care; prevent; Prevention; Privacy; prototype; Public Health; rapid diagnosis; Reporting; Research; Resources; Rest; Sampling; Scientist; Self Care; Sexual Health; Sexually Transmitted Diseases; social stigma; Structure; success; Syphilis; System; targeted treatment; technological innovation; Technology; Testing; Training; Translations; transmission process; United States; Universities; Validation; Woman; Work; World Health Organization; ","Center for Point-of-Care Technologies Research for Sexually Transmitted Diseases","007958","ZEB1","Special Emphasis Panel ","","S1","12","1229605","400744","1630349",""
"9853837","R01","MH","5","N","05/20/2020","02/01/2020","01/31/2021","242","R01MH097236","SCHOOLS OF MEDICINE","PA-16-160","5R01MH097236-08","NIMH:392500\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","DAVIS","UNITED STATES","PSYCHIATRY","03","047120084","US","577503","UNIVERSITY OF CALIFORNIA AT DAVIS","CA","956186153","PROJECT NARRATIVE There is extensive evidence implicating the amygdala in the pathophysiology of autism spectrum disorder (ASD) with ensuing anxiety and key socioemotional impairments. The overarching objective of our research program is to determine the cellular and molecular mechanisms underlying amygdala structure and function in typical human development and in ASD across lifespan. A more thorough understanding of the trajectory of amygdala cellular changes in ASD will pinpoint lifelong opportunities to treatment.","10681703; ","SCHUMANN, CYNTHIA ;","GILOTTY, LISA","09/01/2011","01/31/2023","Abnormal Cell; Adult; Age; age related; Age-Years; Amygdaloid structure; Anxiety; autism spectrum disorder; autistic children; Autopsy; Basal Ganglia; base; BCL2 gene; Brain; Brain Diseases; Brain region; Cell Nucleus; Cells; cellular development; Child; Childhood; Clinical; cohort; Collection; Communication; Data; Dendrites; Dendritic Spines; density; Development; Electron Microscopy; Emotional; Environment; Epilepsy; Equilibrium; excitatory neuron; excitotoxicity; Functional disorder; Funding; gephyrin; Glutamates; Growth; Human; Human Development; Hyperactive behavior; Image; Impairment; inhibitory neuron; Inhibitory Synapse; Label; Lateral; Life; Longevity; Measures; Mental disorders; Methods; Molecular; Neurodevelopmental Disorder; neuron loss; Neurons; neurotransmission; Outcome; Paint; Parvalbumins; Pathologic; Phase; premature; Process; programs; Property; prospective; Research; Resolution; response; Sampling; sensory input; sex; Signal Transduction; social; social anxiety; Social Behavior; Social Interaction; Statistical Data Interpretation; Structure; Synapses; System; targeted treatment; Therapeutic Intervention; Time; Tissue Sample; Vertebral column; Youth; ","Typical and Pathological Cellular Development of the Human Amygdala","097236","DBD","Developmental Brain Disorders Study Section ","","","08","250000","142500","392500",""
"9972736","F31","AG","5","N","05/18/2020","05/20/2020","05/19/2021","866","F31AG063428","SCHOOLS OF ARTS AND SCIENCES","PA-18-671","5F31AG063428-02","NIA:40987\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE ON AGING","","BERKELEY","UNITED STATES","PSYCHOLOGY","13","124726725","US","577502","UNIVERSITY OF CALIFORNIA BERKELEY","CA","947101749","Project Narrative Alzheimer?s disease is associated with changes in sleep physiology and the failure of long-term memory function. The proposed project will investigate whether tau protein, a key feature of Alzheimer?s disease progression, impacts the structure and electrophysiology of sleep in healthy older adults. By characterizing a potential mechanistic pathway linking early tau accumulation, sleep disruption, and memory decline, this research may allow for developing sleep-based therapies for delaying and preventing Alzheimer?s disease.","14427201; ","WINER, JOSEPH ROBERT;","MACKIEWICZ, MIROSLAW","05/20/2019","05/19/2022","abeta accumulation; actigraphy; AD pathology; Address; Aging; Alzheimer disease prevention; Alzheimer's Disease; Alzheimer's disease risk; Alzheimer?s disease biomarker; Amyloid beta-Protein; Anatomy; base; Behavior assessment; Biological Markers; Brain imaging; Brain region; Cognitive; Consequentialism; Coupling; Data; density; Disease Progression; early detection biomarkers; Elderly; Electroencephalography; Electrophysiology (science); experimental study; Failure; Functional disorder; Hippocampus (Brain); Home environment; Human; Impaired cognition; Impairment; in vivo; indexing; insight; Life; Link; long term memory; Measurement; Measures; Medial; Memory; memory consolidation; Memory Loss; memory retention; Methods; middle age; multimodality; non rapid eye movement; novel; Pathologic; Pathology; Pathway interactions; Phase; Positron-Emission Tomography; potential biomarker; pre-clinical; prevent; Process; Recommendation; Research; Risk; Rodent Model; Role; Sensitivity and Specificity; Severities; Sleep; sleep abnormalities; Sleep disturbances; Sleep Fragmentations; sleep physiology; sleep quality; sleep spindle; Slow-Wave Sleep; Structure; symptomatology; targeted treatment; tau aggregation; tau Proteins; Temporal Lobe; Testing; Therapeutic; Work; ","Relationships between tau pathology, sleep physiology and memory in aging","063428","ZRG1","Special Emphasis Panel ","","","02","40987","","40987",""
"9966343","U01","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","U01AI151698","SCHOOLS OF MEDICINE","RFA-AI-19-028","1U01AI151698-01","NIAID:1751002\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","NARRATIVE: University of Washington Arboviral Research Network (UWARN) The University of Washington Arboviral Research Network (UWARN) will address emerging and re-emerging infectious diseases by carrying out research on arboviruses, viruses transmitted by arthropods to humans, with collaborating partner research laboratories in Brazil, Pakistan, Senegal, South Africa and Taiwan. The research will develop innovative new diagnostic reagents, namely human viral-neutralizing antibodies and designed proteins that release light when antibodies to virus are present in blood. UWARN research will also improve understanding of how viruses manipulate the human immune system, facilitating development of better biomarkers to predict severe disease as well as host-directed therapies that could improve outcomes of viral infection.","1940486; 2315853; 1880797 (contact); 8347867; ","GALE, MICHAEL J; RABINOWITZ, PETER MACGARR; VAN VOORHIS, WESLEY C (contact); WASSERHEIT, JUDITH N.;","PATTERSON, JEAN LOIS","05/22/2020","04/30/2025","Acute; Address; Administrative Coordination; Alphavirus; Animals; Antibodies; Antiviral Agents; Arbovirus Infections; Arboviruses; Area; Arthropod Vectors; Arthropods; Back; Bacteriology; base; Binding; biobank; Biological Assay; Biological Markers; Blood; Body Fluids; Brazil; Bunyaviridae; candidate marker; Cell Separation; chikungunya; Chikungunya virus; Clinical; Clinical Management; Clinical Trials; cohort; Collaborations; Collection; Congo; Containment; cross reactivity; Data; data management; Dengue; Dengue Infection; Dengue Virus; design; Detection; Development; Diagnosis; Diagnostic; Diagnostic Reagent; Disease; Emergency Situation; Emerging Communicable Diseases; Engineering; Enzyme-Linked Immunosorbent Assay; Epitopes; experience; Far East; Fever; Flavivirus; Fluorescence; Freezing; Future; Genomic approach; global health; global health emergency; Human; human monoclonal antibodies; Immune response; Immune system; Immunoglobulin G; improved; improved outcome; Individual; Infection; Infectious Diseases Research; Innate Immune Response; Innate Immune System; innovation; Institutes; Institution; International; Intervention; Investigation; Japanese Encephalitis; Knowledge; Laboratories; Laboratory Research; Lead; Light; Logistics; Measurement; Metagenomics; Microcephaly; Molecular; Monitor; Monoclonal Antibodies; Natural Immunity; neutralizing antibody; neutralizing monoclonal antibodies; next generation sequencing; novel; novel diagnostics; novel strategies; Oropouche virus; Outcome; Pakistan; pandemic disease; pandemic preparedness; Parasitic infection; pathogen; Pathogenesis; pathogenic virus; Pathway interactions; Patients; point of care; Population; population based; Prevalence; Process; Production; prospective; Protein Engineering; Proteins; Readiness; Reagent; Research; Resources; Rift Valley Fever; Risk; Sampling; Senegal; Sensitivity and Specificity; Serological; Seroprevalences; Site; South Africa; South America; Specimen; Statistical Data Interpretation; Structure; System; Taiwan; Technology; Technology Transfer; Testing; The science of Mycology; Therapeutic; therapeutic target; Time; transcriptomics; Universities; Vaccines; Variant; Veterinarians; Viral; Viral Antibodies; viral detection; Viral Hemorrhagic Fevers; Viral Load result; virology; Virus; Virus Diseases; virus host interaction; Washington; Yellow Fever; ZIKA; Zika Virus; ","University of Washington Arboviral Research Network (UWARN)","151698","ZAI1","Special Emphasis Panel ","","","01","1301437","449565","1751002",""
"9906230","R01","GM","7","N","05/18/2020","05/01/2020","04/30/2021","859","R01GM084089","","PA-16-160","7R01GM084089-14","NIGMS:454277\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","PHILADELPHIA","UNITED STATES","","03","075524595","US","9340401","WISTAR INSTITUTE","PA","191044265","PROJECT NARRATIVE Most mammalian genes express alternative cleavage and polyadenylation (APA) isoforms with different coding sequences (CDS) and/or 3' untranslated regions (3'UTRs). APA is dynamically regulated under different physiological and pathological conditions, and is rapidly recognized as an important layer of gene regulation. Here we plan to take molecular systems biology approaches to examine how APA is regulated, which so far is poorly understood.","7856818; ","TIAN, BIN ;","BENDER, MICHAEL T","05/01/2008","04/30/2021","3' Untranslated Regions; Address; Affect; base; Bioinformatics; Biological; Cell Differentiation process; Cell Nucleus; Cell physiology; Cell Proliferation; cell type; Cells; Code; Coupled; CRISPR/Cas technology; Cues; Cytoplasm; Development; Elements; Ensure; extracellular; Gene Expression; Gene Expression Regulation; Genes; Genome; Genomics; Goals; Grant; Homeostasis; innovation; interest; knock-down; Label; Lead; Light; lipid biosynthesis; Messenger RNA; Metabolic; Metabolism; Methods; Molecular; Molecular Biology; mRNA Cleavage and Polyadenylation Factors; mRNA Decay; myogenesis; neurogenesis; Nuclear; Nuclear Export; Nuclear RNA; Pathologic; Pattern; Physiological; Polyadenylation; Protein Isoforms; Proteins; recruit; Regulation; response; RNA; RNA Polymerase II; RNA Splicing; RNA Stability; Role; Site; Systems Biology; Thiouridine; Tissues; Transcript; transcription termination; ","Regulation of Alternatiive Cleavage and Polyadenylation","084089","GCAT","Genomics, Computational Biology and Technology Study Section ","","","14","248905","205372","454277",""
"9926305","K01","HL","5","N","05/18/2020","05/01/2020","04/30/2021","838","K01HL130629","","PA-14-044","5K01HL130629-05","NHLBI:97500\","OTHER RESEARCH-RELATED","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","This study proposes a novel investigation of the relationship between miRNAs and treatment response to leukotriene modifying agents, with the ultimate goal of improving therapeutic outcomes in asthma patients. Understanding which patients are likely to benefit from a particular asthma medication will improve patient care and guide physicians in selecting appropriate treatment regimens for their patients, while developing new insights into molecular pathways involved in leukotriene modifier response is expected to aid in development of more effective therapies for asthma.","10380354; ","DAHLIN, AMBER ;","LU, QING","07/15/2016","04/30/2021","Accounting; Adult; Affect; Amber; Applications Grants; Aspirin; aspirin-exacerbated respiratory disease; Asthma; asthmatic; asthmatic patient; Award; B lymphocyte immortalization; B-Lymphocytes; base; Bayesian Network; Bioinformatics; Biological; Blood specimen; career development; Cell model; Cells; Childhood Asthma; Clinical; Clinical Research; cohort; Collaborations; Complex; cysteinyl-leukotriene; Data; Development; differential expression; Disease; disease phenotype; Doctor of Philosophy; effective therapy; Ensure; Enzyme-Linked Immunosorbent Assay; Epidemiology; experience; Expression Profiling; Faculty; Gene Expression; gene product; Genes; Genetic; Genetic Variation; genome wide association study; Goals; Immune response; improved; innovation; insight; Institution; instructor; inter-individual variation; Investigation; Knowledge; Leukotriene Production; Leukotriene Receptor; Leukotrienes; Lung diseases; lymphoblastoid cell line; Measures; medical schools; Medicine; meetings; Mentored Research Scientist Development Award; Mentors; Messenger RNA; Methods; Microarray Analysis; MicroRNAs; Molecular; montelukast; mRNA Expression; National Heart, Lung, and Blood Institute; network models; novel; Oral; Organ; Pathogenesis; Pathway interactions; Patient Care; patient oriented research; patient response; Patients; personalized medicine; Pharmaceutical Preparations; Pharmacology; Physicians; predictive modeling; Principal Investigator; Process; programs; Public Health; recruit; Research; Research Personnel; Respiratory physiology; response; RNA; Role; Sampling; Signal Pathway; skills; Specificity; success; symposium; Testing; therapy outcome; Tissue-Specific Gene Expression; Translational Research; Treatment Efficacy; treatment group; Treatment Protocols; treatment response; Variant; Whole Blood; Work; ","Role of microRNA molecules in therapeutic response to leukotriene modifying agents in asthma","130629","MCBS","NHLBI Mentored Clinical and Basic Science Review Committee ","","","05","97500","0","97500",""
"9940880","K01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","837","K01HL138259","","PA-16-190","5K01HL138259-03","NHLBI:161023\","OTHER RESEARCH-RELATED","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","","07","076593722","US","1504801","BOSTON CHILDREN'S HOSPITAL","MA","021155724","  PROJECT NARRATIVE The proposed research uses a rare confluence of large-scale genomic, clinical, and insurance claims data from tens of millions of individuals to understand how clinical criteria for heart disease impact the different ethnic groups that make up the United States. This research will help cardiologists, geneticists, researchers, and patients understand the range of healthy and unhealthy molecular and clinical variation for two widely used technologies: (1) genetic testing and (2) echocardiography. This information is a prerequisite for rational decision-making with high-dimensional molecular and clinical measurements that is needed to ensure that precision medicine serves all populations in our multi-ethnic society.  ","10161230; ","MANRAI, ARJUN KUMAR;","REDMOND, NICOLE","05/01/2018","04/30/2023","Africa; African American; Age; American; Arrhythmogenic Right Ventricular Dysplasia; Award; Bioinformatics; biomedical data science; biomedical informatics; Boston; burden of illness; Cardiac; cardiac muscle disease; Cardiology; Cardiovascular Diseases; Cardiovascular system; career development; Caring; Catalogs; Clinic; Clinical; clinical practice; Clinical Research; Collaborations; comorbidity; Confusion; cost; Data; Data Set; Databases; Decision Making; Defibrillators; Development; Dilated Cardiomyopathy; disorder risk; Echocardiography; Enrollment; Ensure; ethnic difference; Ethnic group; ethnic minority population; Ethnic Origin; Europe; European; evidence base; exome; falls; Family; Gender; General Population; Genetic; Genetic Risk; Genetic screening method; genetic variant; Genetic Variation; Genome; Genomics; Goals; health care disparity; health disparity; Healthcare Systems; Heart Diseases; high dimensionality; Hospitals; Hypertrophic Cardiomyopathy; Implant; Improve Access; improved; Individual; Inherited; inherited cardiomyopathy; insurance claims; International; K-Series Research Career Programs; Laboratories; Lead; Left Ventricular Hypertrophy; Longitudinal Studies; Measurement; Measures; Medicine; meetings; Mentors; Minority Groups; Molecular; Molecular Abnormality; Morphology; National Heart, Lung, and Blood Institute; Normal Range; novel; Pathogenicity; Pathologic; Patients; Phenotype; Physicians; Play; Population; population health; Population Heterogeneity; Positioning Attribute; Practice Guidelines; precision medicine; Prevalence; prevent; Quantitative Genetics; Recording of previous events; Reference Values; Research; Research Personnel; Research Proposals; Research Training; Risk; risk variant; Societies; sudden cardiac death; Technology; Test Result; Testing; Training; Translating; Translational Research; United States; Validation; Variant; Ventricular Remodeling; Woman; Work; ","Precision Cardiovascular Medicine for Multi-Ethnic Populations","138259","MCBS","NHLBI Mentored Clinical and Basic Science Review Committee ","","","03","149584","11439","161023",""
"9922116","F31","HD","5","N","04/17/2020","05/18/2020","05/17/2021","865","F31HD097079","SCHOOLS OF ARTS AND SCIENCES","PA-18-671","5F31HD097079-02","NICHD:33812\","TRAINING, INDIVIDUAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","COLUMBIA","UNITED STATES","PSYCHOLOGY","04","153890272","US","578002","UNIVERSITY OF MISSOURI-COLUMBIA","MO","652110001","(8) Project Narrative Adolescence is characterized by an increase in internalizing symptoms and friendships are influential sources of emotional support at this time. Understanding links between adolescent physiological responding and their behaviors within friend interactions should have implications for the development of internalizing symptoms. Findings from this study could identify physiological and behavioral targets for interventions aimed at promoting positive youth adjustment.","15210760; ","BOROWSKI, SARAH ;","ESPOSITO, LAYLA E","05/18/2019","05/17/2022","Adolescence; Adolescent; Adult; Affective; base; Behavior; Behavioral; behavioral response; Biological Markers; Cardiac; career; Code; Complement; course development; Data; Development; developmental psychology; Disease; Emotional; Ensure; Environment; Foundations; Friends; Friendships; Future; Gender; Goals; Health; indexing; Influentials; Informal Social Control; Intervention; Life; Link; Manuscripts; Measurement; Measures; Mental Health; Methodology; Methods; Modeling; Monitor; Mother-Child Relations; Observational Study; Outcome; Parasympathetic Nervous System; Participant; Pattern; Physiological; Physiological Processes; Play; Positioning Attribute; Prevalence; programs; Psychopathology; Regulation; Research; Research Personnel; Research Training; Respiration; respiratory; response; Rest; Risk; Role; Same-sex; Series; Severities; sex; Sinus Arrhythmia; skill acquisition; skills; Social Behavior; Social Functioning; Social Well-Being; Source; Surveys; Symptoms; tenure track; Testing; Time; Training; trait; Universities; Well in self; Work; Writing; Youth; ","The role of vagal tone in adolescent social behaviors","097079","ZRG1","Special Emphasis Panel ","","","02","33812","","33812",""
"9923012","R01","NS","5","N","05/21/2020","05/01/2020","04/30/2021","853","R01NS102665","SCHOOLS OF MEDICINE","PA-16-160","5R01NS102665-03","NINDS:460820\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","NEW YORK","UNITED STATES","NEUROSURGERY","12","121911077","US","5998304","NEW YORK UNIVERSITY SCHOOL OF MEDICINE","NY","10016","PROJECT NARRATIVE  We  recently  discovered  that  GPR133,  a  cell  surface  receptor,  is  critical  for  growth  of  glioblastoma,  a  deadly  brain malignancy. The proposed study will determine cellular and molecular mechanisms that GPR133 utilizes  to  promote  tumor  progression.  We  envision  GPR133  inhibition  as  a  novel  therapeutic  alternative  against  this  otherwise refractory cancer. ","8842743; ","PLACANTONAKIS, DIMITRIS G.;","FOUNTAIN, JANE W","08/01/2018","04/30/2023","Adhesions; Adult; Angiogenesis Inhibitors; Automobile Driving; base; Behavior; Biological Assay; Biopsy; Blood Vessels; Brain; brain tissue; cell behavior; Cell membrane; Cell Surface Receptors; Cells; chemoradiation; Complement; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Data; Development; Differentiation Antigens; Disease; Dissection; Endothelial Growth Factors Receptor; extracellular; Failure; Family; Future; G-Protein-Coupled Receptors; Gene Expression Profiling; Gene Expression Regulation; Genetic; Genetic Transcription; Glioblastoma; Growth; GTP-Binding Proteins; Human; Hypoxia; Impairment; In Vitro; in vivo; knock-down; Lead; Ligands; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Mediating; Mediator of activation protein; member; Messenger RNA; Methods; Modeling; Molecular; molecular subtypes; Molecular Target; mRNA Expression; Mus; N-terminal; neoplastic cell; new therapeutic target; notch protein; novel; novel strategies; novel therapeutics; Orphan; overexpression; Oxygen; Pathway interactions; Patients; Penetrance; Perfusion; Pharmacology; Phenotype; Physiological; prevent; Property; Proteins; Publications; Publishing; receptor function; Refractory; Regulation; Research; Resistance; Role; Signal Transduction; Signaling Protein; small hairpin RNA; small molecule inhibitor; Specimen; stem; Stem cells; stem-like cell; stemness; Stratification; Structure; Surface; Telomerase; Testing; The Cancer Genome Atlas; Therapeutic; therapy resistant; TNFSF15 gene; transcription factor; Transcriptional Regulation; transcriptome; tumor; tumor growth; tumor hypoxia; tumor initiation; Tumor Initiators; tumor microenvironment; Tumor Oxygenation; tumor progression; Tumor Tissue; tumor xenograft; Tumor-Derived; tumorigenesis; vessel regression; Xenograft procedure; ","The role of GPR133 in glioblastoma","102665","TCB","Tumor Cell Biology Study Section ","","","03","271870","188950","460820",""
"10047898","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI154318","SCHOOLS OF MEDICINE","PA-19-053","1R21AI154318-01","NIAID:234000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEWARK","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","10","078795851","US","10034169","RBHS-NEW JERSEY MEDICAL SCHOOL","NJ","071032757","Project Narrative This project is relevant to the mission of the NIH because Cryptococcus neoformans is an important AIDS- associated human pathogen that is difficult to treat with limited drug options, and this project aims to understand a novel mechanism of antifungal drug resistance. Characterizing how lipid translocation contributes to antifungal drug resistance will identify new drug targets and will guide efforts to develop new disease prevention and control strategies. !","9701030; ","XUE, CHAOYANG ;","LOVE, DONA","05/22/2020","04/30/2022","3-Dimensional; Acquired Immunodeficiency Syndrome; AIDS/HIV problem; Amphotericin B; Antibodies; Antifungal Agents; Antifungal Therapy; ATP phosphohydrolase; Bacteria; base; Binding; Biochemical Genetics; Calcineurin Pathway; Calcium; Caspofungin; Cell membrane; Cell surface; Cellular Assay; Cellular Membrane; Cessation of life; Chemicals; Combined Modality Therapy; Cryptococcosis; Cryptococcus; Cryptococcus neoformans; Data; Development; Disease; disorder control; disorder prevention; drug development; Drug resistance; Drug resistance pathway; drug sensitivity; Drug Targeting; echinocandin resistance; Enzymes; Epitopes; extracellular; Fab Immunoglobulins; Fluconazole; Fungal Drug Resistance; fungus; Future; Generations; genetic approach; glucan synthase; Goals; Homeostasis; Human; human pathogen; Immunoglobulin Fragments; Impairment; in vivo; Industrial fungicide; Infection; inhibitor/antagonist; Lead; Lipid Bilayers; Lipids; Liposomes; macrophage; Mediating; Membrane; Membrane Proteins; Mission; Modeling; Molecular; Molecular Weight; Monoclonal Antibodies; mouse model; Mus; mutant; Mycoses; new therapeutic target; novel; pathogenic fungus; Pharmaceutical Preparations; Phosphatidylserines; Phospholipids; polyclonal antibody; Polyenes; pre-clinical; Reporting; Research; research and development; Resistance; resistance mechanism; Role; Sequence Homology; success; Surface; System; Testing; Therapeutic; tool; Toxic effect; trafficking; Treatment Protocols; Triazoles; Ubiquitin; United States National Institutes of Health; Vesicle; Virulence; yeast two hybrid system; ","Lipid flippase in echinocandin drug resistance in Cryptococcus neoformans","154318","ZRG1","Special Emphasis Panel ","","","01","150000","84000","234000",""
"9930681","R01","HL","5","N","05/18/2020","05/01/2020","04/30/2021","838","R01HL142269","SCHOOLS OF MEDICINE","PA-16-160","5R01HL142269-03","NHLBI:767433\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PHILADELPHIA","UNITED STATES","BIOSTATISTICS & OTHER MATH SCI","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Project Narrative The hepatopulmonary syndrome (HPS) is a common disorder of the lung vasculature in cirrhosis that impairs the transfer of oxygen into the blood. The current proposal will focus on mechanisms which may explain why certain patients with liver disease have a higher chance of developing HPS. This study will examine the role of abnormal growth of vessels in the lung due to sphingolipid imbalance and destruction of alveolar cells by bile acids as causes of HPS.","6670647; ","KAWUT, STEVEN M;","AGGARWAL, NEIL R","06/01/2018","04/30/2023","Address; Affect; Age; Alveolar; Alveolar Cell; alveolar destruction; alveolar epithelium; alveolar type II cell; American; angiogenesis; Animal Model; Animals; Apoptosis; Bile Acids; Blood; Blood Vessels; Cause of Death; cell injury; Cells; ceramide 1-phosphate; Ceramides; Cirrhosis; Clinical; Clinical Treatment; Clinical Trials; cohort; Complication; cost; Data; Development; Dilatation - action; disorder control; Dyspnea; Etiology; Experimental Animal Model; Experimental Models; Functional disorder; Funding; Gases; Generations; Goals; Growth; Hepatopulmonary Syndrome; Human; Impairment; Incidence; Individual; inhibitor/antagonist; insight; Intervention Studies; Knowledge; Lead; Link; Liver diseases; liver transplantation; Lung; Lung diseases; Medical; mortality; mortality risk; Multicenter Studies; novel; Outcome; Oxygen; Pathogenicity; Pathway interactions; patient oriented research; Patients; Plasma; Portal Hypertension; post-transplant; potential biomarker; Process; Prospective cohort study; Public Health; Pulmonary Surfactant-Associated Protein D; Quality of life; Randomized Clinical Trials; Research Personnel; Resolution; Risk; Role; Severities; Signal Transduction; Smoking; Sphingolipids; sphingosine 1-phosphate; sphingosine kinase; SPHK1 enzyme; Study models; surfactant; surfactant production; Surrogate Endpoint; Symptoms; Syndrome; targeted therapy trials; Therapeutic; therapeutic target; United States National Institutes of Health; Vascular Diseases; Vascular Endothelium; ","Novel Mechanisms of Hepatopulmonary Syndrome","142269","IRAP","Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section ","","","03","593093","174340","767433",""
"9937764","U24","HG","5","N","05/19/2020","05/01/2020","04/30/2021","172","U24HG003345","","PAR-17-273","5U24HG003345-15","NHGRI:550000\","OTHER RESEARCH-RELATED","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","HEIDELBERG","GERMANY","","","321691735","GM","9653901","EUROPEAN MOLECULAR BIOLOGY LABORATORY","","69117","To ensure effective communication between basic and clinical researchers, practicing clinicians and patients, there has to be a consistent well managed set of names for all human genes, which HGNC has provided since 1979. Having these names enables new discoveries, avoids confusion and prevents patient harm, by helping to ensure that everyone refers to a given gene using the same name.","8790630 (contact); 11261888; 10353388; 1967346; 11236293; 14721832; 12617441; 14112474; ","BIRNEY, EWAN  (contact); BRUFORD, ELSPETH ; GOLDSTONE, JARED VERRILL; LANCET, DORON ; NELSON, DAVID R; OLENDER, TSVIYA ; OUWEHAND, WILLEM ; ZERBINO, DANIEL ROBERT;","WELLINGTON, CHRISTOPHER","09/15/2004","04/30/2023","Animal Model; Area; authority; base; Biology; Canis familiaris; Cattle; Chickens; Clinical; clinical practice; clinically relevant; Code; Collaborations; Communication; Complex; Confusion; Consensus; Coupled; Cytochrome P450; Data; data exchange; Data Set; Databases; Drug Metabolic Detoxication; Ensure; Equus caballus; Family; Freezing; Funding; Future; Gene Duplication; Gene Family; gene product; Gene Transfer; Genes; Genome; genomic data; Glucuronosyltransferase; Glutathione S-Transferase; Goals; Healthcare; Human; Human Genome; human genomics; interest; Language; Lead; Learning; Life; Machine Learning; Mammals; Manuals; member; Modeling; multiple data sources; Mus; Names; Nomenclature; novel; olfactory receptor; Open Reading Frames; Orthologous Gene; Pan Genus; parallelization; Patients; Pharmacology; Phenotype; precision medicine; prevent; Process; Proteins; prototype; Pseudogenes; Public Health; Publications; Publishing; Rattus; Research Personnel; Resources; RNA; Science; Source; Standardization; Study models; success; Syntenic Conservation; tool; Training; Untranslated RNA; Update; user-friendly; vertebrate genome; Vertebrates; web site; Work; Xenopus; Zebrafish; ","The Nomenclature of Human and Vertebrate Genes","003345","ZHG1","Special Emphasis Panel ","","","15","534772","15228","550000",""
"9964674","U54","CA","5","N","05/18/2020","05/01/2020","04/30/2021","397","U54CA209988","SCHOOLS OF MEDICINE","RFA-CA-15-014","5U54CA209988-04","NCI:1835653\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","OTHER BASIC SCIENCES","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","Project narrative This Project will improve management of triple negative breast cancer (TNBC) by understanding and managing heterogeneity arising from epigenomic instability intrinsic to cancer cells and from diverse signals from extrinsic microenvironments in which cancer cells reside.","10311900; 1943901 (contact); 1938469; 8180078; ","DEMIR, EMEK ; GRAY, JOE W. (contact); SEARS, ROSALIE C; TOMLIN, CLAIRE J;","HUGHES, SHANNON K","05/22/2017","04/30/2022","3-Dimensional; analytical tool; bioimaging; bioprinting; Breast Cancer Cell; cancer cell; Cancer cell line; Cancer Control; Cell Line; Cell model; Cells; Cellular Structures; Characteristics; Clinical; Clonal Expansion; combinatorial; Communities; Complex; computational suite; Computer Models; computerized tools; Custom; Data; Data Analyses; data integration; data management; Databases; Drug Targeting; Educational Materials; Electron Microscopy; Engineering; Ensure; Environment; epigenomics; Evaluation; Exhibits; experimental study; FDA approved; feature extraction; Genomics; Goals; Heterogeneity; Image; Image Analysis; image visualization; Imaging technology; Immunofluorescence Immunologic; improved; In Vitro; in vivo; Infrastructure; Leadership; Learning; light microscopy; Link; Machine Learning; Malignant Neoplasms; MDA-MB-468; Measurement; Measures; Mediating; metabolomics; Metadata; Methods; Microarray Analysis; Modeling; Molecular; multidisciplinary; network models; novel; open source; outreach; Pathway interactions; Patients; Periodicity; Pharmaceutical Preparations; Pharmacology; Phenotype; Pilot Projects; Plant Roots; prevent; Procedures; Proteins; quantitative imaging; Reagent; Resistance; response; SDZ RAD; Signal Transduction; Site; Source; Specimen; Stress; Structure; System; Systems Analysis; Systems Biology; targeted treatment; Therapeutic; therapy resistant; Tissues; Training; treatment response; triple-negative invasive breast carcinoma; tumor; Visualization; Work; Xenograft procedure; ","Measuring, Modeling and Controlling Heterogeneity","209988","ZCA1","Special Emphasis Panel ","","","04","1275824","559829","1835653",""
"9912645","R01","DE","5","N","05/19/2020","05/01/2020","04/30/2021","121","R01DE012505","SCHOOLS OF DENTISTRY/ORAL HYGN","PA-16-160","5R01DE012505-23","NIDCR:365750\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH","","LOUISVILLE","UNITED STATES","DENTISTRY","03","057588857","US","4679701","UNIVERSITY OF LOUISVILLE","KY","402920001","Diseases caused by mixtures of bacteria are often more serious and harder to treat that those caused by a single organism. Periodontal (gum) diseases are caused by mixtures of organisms that communicate with each other to become more aggressive. In this proposal we shall study the communication mechanisms that allow groups of periodontal bacteria to increase in number and resist killing by the host.","7355414; ","LAMONT, RICHARD J;","MELILLO, AMANDA A","09/01/1998","04/30/2023","Adhesions; Adopted; Alveolar Bone Loss; Animal Model; Bacteria; Bacterial Adhesins; base; bone loss; Communication; Communities; Complex; Cues; Data; design; Detection; Development; Disease; Event; Exhibits; Fimbrial Adhesins; Genes; Genetic Transcription; Goals; Grant; Human; In Vitro; in vivo; Individual; Infection; Inflammatory; insight; Investigation; Measures; Mediating; Membrane Proteins; Metabolic; microbial community; Modeling; Molecular; multimodality; Mus; Mutation; neutrophil; novel; oral infection; oral plaque; Organism; Oxidative Stress; pathogen; Pathogenesis; Pathogenicity; Periodontal Diseases; Phosphoric Monoester Hydrolases; Phosphorylation; polymicrobial disease; Porphyromonas gingivalis; prevent; Process; Production; Protein Tyrosine Kinase; Protein Tyrosine Phosphatase; Proteome; Regulation; Regulon; Resistance; response; Role; Shapes; Signal Transduction; small molecule; Streptococcus; Streptococcus gordonii; synergism; System; Therapeutic; transcriptome; Translating; Tyrosine; Tyrosine Phosphorylation; Up-Regulation; Virulence; ","Molecular Aspects of Oral Plaque Formation","012505","ODCS","Oral, Dental and Craniofacial Sciences Study Section ","","","23","237500","128250","365750",""
"10131442","R35","GM","3","N","05/20/2020","05/01/2020","04/30/2021","859","R35GM133470","SCHOOLS OF ARTS AND SCIENCES","PA-18-906","3R35GM133470-02S1","NIGMS:103142\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","CHICAGO","UNITED STATES","CHEMISTRY","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","Project Narrative  This is a request for a diversity supplement to the existing grant R35GM133470 to hire Jorge Martinez as a post-doctoral scholar. Jorge Martinez is an outstanding Ph.D. candidate in the laboratory of Jeremy Smith. When he joins our group, Jorge will work on studying the fundamental effects of anionic charges on coordination complexes, particularly oxo complexes.","11898960; ","ANDERSON, JOHN STUART;","ANDERSON, VERNON","07/01/2019","04/30/2024","Active Sites; Affect; alkalinity; Anions; Biological; career; Charge; Chelating Agents; Communication; Communities; Complex; Distal; Doctor of Philosophy; electric field; electronic structure; Evolution; Faculty; Grant; Hydrogen Bonding; insight; Institution; Investigation; Laboratories; Ligands; Link; Modeling; molecular modeling; oxidation; Oxidation-Reduction; Oxygen; Positioning Attribute; Postdoctoral Fellow; programs; Property; Reaction; Research; Structure; System; Techniques; Training; Training Programs; Transition Elements; Work; ","Distal Anion Stabilization of Biologically Relevant Oxo Intermediates - Diversity Supplement","133470","ZGM1","Special Emphasis Panel ","","S1","02","63668","39474","103142",""
"9928297","R35","GM","5","N","05/21/2020","05/01/2020","04/30/2021","859","R35GM118191","SCHOOLS OF ARTS AND SCIENCES","RFA-GM-16-002","5R35GM118191-05","NIGMS:551982\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","PASADENA","UNITED STATES","NONE","27","009584210","US","1073501","CALIFORNIA INSTITUTE OF TECHNOLOGY","CA","911250001","PUBLIC HEALTH RELEVANCE: The enantioselective synthesis of chiral small molecules is a scientific area of fundamental importance to the discovery of new medicines. This proposal seeks to develop both new synthetic tools - chemical reactions - and design strategies to enable the efficient preparation of structurally complex, bioactive molecules. In doing so, this research will accelerate the discovery of new medicines and enable study and treatment of human disease.","9897523; ","REISMAN, SARAH ELIZABETH;","YANG, JIONG","05/01/2016","04/30/2021","Address; Alkaloids; Area; catalyst; chemical reaction; chemical synthesis; Chemicals; Chemistry; Complex; Coupling; design; Development; Diterpenes; drug candidate; drug discovery; Drug Industry; Exhibits; Family; functional group; Goals; graduate student; human disease; Lead; Logic; Medicine; Metals; Methods; Natural Products; Nickel; Organic Chemistry; Outcomes Research; Planet Earth; Preparation; Process; programs; public health relevance; Reaction; Reagent; Reducing Agents; Research; research clinical testing; Research Personnel; Series; small molecule; Structure; success; theories; tool; Training; ","Chemical Synthesis of Chiral Bioactive Molecules","118191","ZGM1","Special Emphasis Panel ","","","05","357000","194982","551982",""
"10088064","U01","MH","3","N","05/22/2020","05/05/2020","03/31/2021","242","U01MH119738","","PA-18-591","3U01MH119738-02S1","NIMH:387794\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PHILADELPHIA","UNITED STATES","","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","PROJECT NARRATIVE Neuropsychiatric manifestations are common in Rare Genetic Disorders (RGDs), affecting brain development and functioning throughout the lifespan; copy number variants (CNVs) at 22q11.2 and 16p11.2 loci are among the most common RGDs impacting developmental psychopathology. We propose to capitalize on highly informative samples and integrate prospective dimensional and categorical phenotyping with whole genome sequencing across these reciprocal CNVs. This work will identify convergent risk mechanisms for developmental neuropsychiatric disorders that have relevance to the broader population.","8498100; ","GUR, RAQUEL E;","FRIEDMAN-HILL, STACIA","06/20/2019","03/31/2024","16p11.2; 22q11.2; adverse outcome; Affect; Algorithms; Anxiety; Anxiety Disorders; Architecture; Attention; Attention deficit hyperactivity disorder; Attentional deficit; autism spectrum disorder; base; Brain; brain behavior; case control; Categories; Clinical; clinical Diagnosis; clinical phenotype; clinical predictors; Cognition; Cognitive; cohort; Collaborations; Complement; Complex; Computing Methodologies; Copy Number Polymorphism; Custom; Data; Data Analytics; Development; Developmental Course; Developmental Delay Disorders; Diagnosis; Dimensions; Disease; Early Intervention; Emotional; Emotions; Environment; Environmental Risk Factor; Evaluation; experience; externalizing behavior; Family; Family member; Genes; Genetic; genetic architecture; Genetic Determinism; genetic pedigree; Genetic Predisposition to Disease; Genetic study; genetic variant; genome sequencing; genome wide association study; Genomics; Goals; Heterogeneity; Hyperactive behavior; Individual; Institution; Intellectual functioning disability; interest; International; Knowledge; large datasets; Lead; Literature; Longevity; Measures; Memory; Mental Depression; Mind; Modeling; Molecular; National Institute of Mental Health; Nature; neurobehavioral; neurobiological mechanism; Neurocognition; neuropsychiatric disorder; neuropsychiatry; Online Systems; Outcome; Patients; personalized approach; phenomics; Phenotype; Population; Positioning Attribute; processing speed; prospective; Psychiatric Diagnosis; Psychopathology; Psychotic Disorders; Public Domains; rare genetic disorder; rare variant; recruit; Recurrence; Resources; Risk; risk prediction model; Sampling; Schizophrenia; social; Social Behavior; Specificity; Structure; symptomatology; Symptoms; Syndrome; theories; tool; Variant; whole genome; Work; ","1/9: Dissecting the effects of genomic variants on nenriched for neuropsychiatric disorderseurobehavioral dimensions in CNVs ","119738","ZMH1","Special Emphasis Panel ","","S1","02","239379","148415","387794",""
"10106452","I01","VA","5","N","05/22/2020","01/01/2020","12/31/2020","999","I01BX002908","","RFA-BX-15-001","5I01BX002908-05","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","SALT LAKE CITY","UNITED STATES","","02","009094756","US","481089","VA SALT LAKE CITY HEALTHCARE SYSTEM","UT","841480001","PUBLIC HEALTH RELEVANCE        Veterans exhibit a higher risk for major depression (MDD), treatment-resistant depression (TRD) and suicide. Female veterans face an even greater depression burden and elevated MDD-based disability status. MDD and suicide rates are also higher in those living at altitude and with chronic hypoxic disorders such as COPD, asthma and smoking. In animal models, hypoxia reduces brain serotonin, and SSRIs lose efficacy with low brain serotonin, implying that high MDD and TRD rates are likely in chronic hypoxia, thereby increasing suicide risk. Using a translational animal model, we will study MDD in chronic hypoxia by examining (1) the efficacy of SSRIs and other antidepressants to identify those most optimal for hypoxia-related MDD, and (2) the potential of dietary 5HTP, creatine and 5HTP+creatine (± SSRI) to restore hypoxia-induced brain deficits, reduce depression and improve SSRI efficacy. Focused on MDD in women, this proposal meets 3 of the 8 priority research areas of interest to the BLR&D: Suicide Prevention, Women's Health and Risky Behavior (Smoking).","1877467; ","RENSHAW, PERRY FRANKLIN;","","01/01/2016","12/31/2020","5-Hydroxytryptophan; Address; Adult; aged; Altitude; Animal Model; Antidepressive Agents; Area; Asthma; base; Behavior; Bioenergetics; Brain; Brain region; Bypass; Cerebrum; Chronic; Chronic Disease; Chronic Obstructive Airway Disease; Cigarette Smoker; Clinical; combat; Communities; comorbid depression; Corpus striatum structure; Creatine; Data; Depression and Suicide; Diagnosis; Diet; disability; Disease; Drops; effective therapy; efficacy testing; Etiology; Exhibits; experience; Exposure to; Face; Feeling suicidal; Female; field study; Fluoxetine; forced swim test; Future; Gender; General Population; Goals; Health; Health behavior; Health Status; high risk; Housing; Human; Hypoxia; improved; interest; Intervention; Link; Longevity; Major Depressive Disorder; male; Measures; Mental Depression; Mental Health; Metabolism; Modeling; monoamine; motor behavior; neurochemistry; noradrenergic; novel; novel therapeutics; Oxygen; Partial Pressure; Population; Post-Traumatic Stress Disorders; preference; Prevalence; Prevention Research; programs; Prosencephalon; public health relevance; Rattus; receptor; reducing suicide; Reporting; Research Priority; response; Risk; Risk Behaviors; Saline; Sea; Selective Serotonin Reuptake Inhibitor; Serotonin; Smoking; standard of care; Sucrose; suicidal risk; Suicide prevention; suicide rate; System; Testing; Therapeutic; Traumatic Brain Injury; treatment effect; Treatment outcome; treatment-resistant depression; Veterans; Woman; Women's Health; young woman; ","Improving Therapeutic Options for Hypoxia-related Depression with an Animal Model","002908","NURA","Neurobiology A ","","","05","","","",""
"9930674","R01","HL","5","N","05/17/2020","05/01/2020","04/30/2021","233","R01HL139716","SCHOOLS OF PUBLIC HEALTH","PA-16-160","5R01HL139716-03","NHLBI:913796\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BIRMINGHAM","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","063690705","US","1288803","UNIVERSITY OF ALABAMA AT BIRMINGHAM","AL","352940001","The way that blood pressure is being measured in clinical practice may lead to the misdiagnosis of hypertension. This study will test a new approach for measuring blood pressure in the clinic for accurately diagnosing hypertension. We will also test a new approach for measuring blood pressure while people sleep.","6296659 (contact); 7120933; ","MUNTNER, PAUL  (contact); SHIMBO, DAICHI ;","EINHORN, PAULA T","07/15/2018","04/30/2022","accurate diagnosis; Adopted; Adult; Advisory Committees; Affect; Agreement; Albumins; Albuminuria; Ambulatory Blood Pressure Monitoring; Antihypertensive Agents; awake; Blood Pressure; blood pressure intervention; blood pressure reduction; Canada; cardiovascular disorder risk; Clinic; clinical practice; Contusions; Creatinine; Data; Data Analyses; Devices; Diagnosis; diagnosis standard; Diastolic blood pressure; Enrollment; Equipoise; Expert Opinion; Goals; Guidelines; Health behavior; Health Personnel; Home Blood Pressure Monitoring; Home environment; Hour; Hypertension; indexing; Intervention Trial; Lead; Left Ventricular Mass; Level of Evidence; masked hypertension; Measurement; Measures; Mercury; Methods; Monitor; monitoring device; New York; novel; novel strategies; Organ; Pain; Participant; Patients; Personal Communication; Persons; Pharmaceutical Preparations; Phenotype; Prevalence; Preventive service; Procedures; Psychosocial Factor; Public Health; Recommendation; Reference Standards; Research Design; Risk; screening; Sleep; Sphygmomanometers; Testing; Time; urinary; Visit; white coat hypertension; ","Evaluating novel approaches for estimating awake and sleep blood pressure","139716","CICS","Clinical and Integrative Cardiovascular Sciences Study Section ","","","03","718546","195250","913796",""
"9964675","U54","CA","5","N","05/18/2020","05/01/2020","04/30/2021","","U54CA209988","","RFA-CA-15-014","5U54CA209988-04","NCI:226782\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","1943901; ","GRAY, JOE W.;","","","","Administrator; Advisory Committees; analytical tool; Award; base; bioimaging; Collaborations; Communication; Communities; computer infrastructure; Computer Models; crowdsourcing; Data; Data Analyses; Development; Educational workshop; Ensure; Evaluation; Event; Faculty; Funding; Group Meetings; Heterogeneity; Human Resources; Image; Image Analysis; Infrastructure; instrumentation; Intellectual Property; Leadership; light microscopy; Logistics; Malignant Neoplasms; Measurement; Measures; meetings; member; Mentors; Metadata; Microscopy; Modeling; multidisciplinary; National Cancer Institute; Network Infrastructure; outreach; Pilot Projects; Preparation; programs; Reporting; Research; Research Personnel; Resource Sharing; Resources; Scientific Evaluation; Scientist; Site; Site Visit; symposium; Synapses; System; Systems Biology; Technology; Training; user-friendly; Videoconferences; Voting; web site; Work; ","Administrative Core","209988","ZCA1","Special Emphasis Panel ","8355","","04","148919","77863","","226782"
"9920115","R25","DA","5","N","05/18/2020","05/01/2020","04/30/2021","279","R25DA035163","SCHOOLS OF MEDICINE","PAR-16-224","5R25DA035163-07","NIDA:412011\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","SAN FRANCISCO","UNITED STATES","PSYCHIATRY","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","PROJECT NARRATIVE While the U.S. population becomes more racially/ethnically diverse, underrepresentation of African Americans, Latinos, and American Indian/Alaska Natives among NIH-funded investigators persists. To address this important leadership gap, the proposed program provides training to early-stage research scientists from underrepresented groups or disadvantaged backgrounds, aiming to increase the number of racial/ethnic minority scientists leading culturally relevant behavioral or pharmacological substance use treatment research. The goal is to produce multidisciplinary research leaders and strengthen the research and training network of the NIH, NIDA, and its partnering organizations.","1892921 (contact); 1888427; ","MASSON, CARMEN L. (contact); SORENSEN, JAMES L.;","WILEY, TISHA R A","05/01/2014","04/30/2024","addiction; Address; African American; Alaska Native; Alcohol or Other Drugs use; American Indians; Applications Grants; Award; base; Behavioral; California; career; career development; Clinical; Clinical Research; Clinical Sciences; Clinical Treatment; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Data; design; Disadvantaged; Drug abuse; education research; Educational Curriculum; Educational workshop; Effectiveness; Ethics; ethnic diversity; ethnic minority population; Evaluation; Evidence based treatment; Faculty; Fostering; Foundations; Funding; Goals; Grant; health care service organization; Health Policy; implementation research; implementation science; Infrastructure; innovation; Institutes; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Knowledge; Latino; Leadership; Learning; Measurable; Medical; meetings; Mentors; Methodology; Methods; Minority Groups; minority investigator; minority scientist; Mission; Multi-Institutional Clinical Trial; National Clinical Trials Network; National Institute of Drug Abuse; Outcome; Participant; Pathway interactions; Pharmacologic Substance; Population; Postdoctoral Fellow; Primary Health Care; professor; programs; racial and ethnic; recruit; Research; research and development; research data dissemination; Research Methodology; Research Personnel; Research Priority; Research Training; Resources; San Francisco; Science; Scientist; Senior Scientist; skills; sound; Structure; Substance Use Disorder; support network; Testing; Training; Training Programs; Translational Research; Underrepresented Groups; United States National Institutes of Health; Universities; Work; Writing; ","Mentoring Emerging Scientists for Careers in Substance Use Research","035163","ZDA1","Special Emphasis Panel ","","","07","381492","30519","412011",""
"9925233","R01","HL","5","N","05/20/2020","04/01/2020","03/31/2021","839","R01HL089456","BIOMED ENGR/COL ENGR/ENGR STA","PA-16-160","5R01HL089456-09","NHLBI:591303\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","ITHACA","UNITED STATES","ENGINEERING (ALL TYPES)","23","872612445","US","1514802","CORNELL UNIVERSITY","NY","148502820","Cardiovascular devices that are implanted today carry a risk of un-intended blood clotting, which may cause serious injury including stroke and bleeding. The purpose of this project is to create a computer simulation program that will predict when this might occur, and thereby help doctors adjust dosage of blood-thinners, and guide developers of these devices to produce more safe and effective devices.","2199651; ","ANTAKI, JAMES F.;","QASBA, PANKAJ","05/01/2018","03/31/2021","Adhesions; Adverse event; Agonist; Agreement; Animals; Anticoagulants; Anticoagulation; Antithrombin III; Aspirin; Basic Science; Biochemical; Biological Phenomena; Blood; Blood Cells; Blood Circulation; Blood coagulation; blood oxygenator; Blood Platelets; blood pump; Calcium; Cardiovascular system; Chemicals; Chemistry; Clinical; Clinical Trials; clinically relevant; clopidogrel; Computer Models; Computer Simulation; Computers; Convection; cost; Deposition; design; Development; Devices; Diffusion; dosage; Elements; Erythrocytes; Event; experience; Feedback; Forensic Medicine; Growth; Heart-Lung Transplantation; Hematocrit procedure; Hematology; hemodynamics; Hemorrhage; implantable device; improved; Incidence; Infection; Injury; International; Liquid substance; Maps; Mathematics; Mediating; meetings; Membrane Oxygenators; Methods; Microfluidics; Modeling; multi-scale modeling; neglect; Numeric Rating Scale; Pathway interactions; patient population; Patients; Pattern; Performance; Phase; Platelet Count measurement; predictive modeling; pressure; Process; programs; Property; Reaction; Reporting; Risk; Risk Management; Saint Jude Children's Research Hospital; Side; simulation; Societies; Stents; Stroke; success; Surface; synergism; Thrombin; thrombolysis; Thrombosis; Thrombus; tool; trafficking; Translations; Transplantation; Triad Acrylic Resin; ventricular assist device; virtual; ","Multiscale Model of Thrombosis in Artificial Circulation","089456","BTSS","Bioengineering, Technology and Surgical Sciences Study Section ","","","09","509760","81543","591303",""
"9922877","R01","DA","5","N","05/18/2020","04/01/2020","03/31/2021","279","R01DA035868","SCHOOLS OF MEDICINE","PA-16-076","5R01DA035868-06","NIDA:634750\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","PHILADELPHIA","UNITED STATES","PATHOLOGY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Narrative  Resubmission: Develop Point-of-Care Volumetric-Bar-Chart-Chip for Drug Quantitation Current point-of-care (POC) methods for the measurement of illicit drugs suffer from non- quantitation, low accuracy, low throughput and long turn-around time. In this application, we proposed to develop an Integrated Competitive Volumetric Bar Chart Chip (ICV-Chip) to assay multiple drug targets in diverse clinical samples, which integrates the abilities to fully address the above-mentioned limitations. The development of the ICV-Chip holds the potential to meet the challenges listed in the PA-16-076 grant mechanism.","10635293; 9310795 (contact); ","QIN, LIDONG ; WANG, PING  (contact);","MOORE, HOLLY MARIE","07/15/2013","03/31/2021","Acetazolamide; Address; Adherence; Antibodies; Award; Bar Codes; base; Biological; Biological Assay; Blood; Blood specimen; Calibration; Cellular Phone; Clinic; Clinical; clinical practice; Clinical Sensitivity; Clinical Trials; Cloud Computing; commercialization; Complex; compliance behavior; computerized data processing; Computers; cost; Data; Decision Making; design; Development; Devices; Drug abuse; Drug Screening; Drug Targeting; drug testing; Environment; Enzyme-Linked Immunosorbent Assay; Equipment; Fingers; Gas Chromatography; Glass; Gold; Grant; Healthcare; Home environment; Hospitals; Illicit Drugs; Image; Immunoassay; improved; innovation; instrument; instrumentation; internal control; Laboratories; Lasers; Legal patent; Liquid Chromatography; Manuals; mass spectrometer; Measurement; Measures; Medical; Medicine; meter; Methods; Microfabrication; miniaturize; minimally invasive; operation; Outpatients; Paper; Patients; Peer Review; Pennsylvania; Pharmaceutical Preparations; point of care; portability; Procedures; Process; Production; Publications; Publishing; Pump; Reader; Reading; research and development; Saliva; sample collection; Sampling; screening; Slide; Specificity; Specimen; Spottings; Substance Abuse Detection; Substance Use Disorder; System; Techniques; Technology; Telemedicine; Testing; Therapeutic; Therapeutic Clinical Trial; Time; Treatment Efficacy; University Hospitals; Urine; user-friendly; Validation; Visit; Weight; Whole Blood; ","Development of a Point-of-Care Volumetric Bar-Chart Chip for Drug Quantitation","035868","ZRG1","Special Emphasis Panel ","","","06","526423","108327","634750",""
"9961842","U01","AI","1","N","05/18/2020","05/18/2020","04/30/2021","855","U01AI151378","","RFA-AI-19-029","1U01AI151378-01","NIAID:814714\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","RESEARCH TRIANGLE PARK","UNITED STATES","","04","004868105","US","6939101","RESEARCH TRIANGLE INSTITUTE","NC","277092194","PROJECT NARRATIVE Emerging and re-emerging infectious diseases are occurring with increasing frequency and are a threat to human health in the United States and worldwide. To improve knowledge of these diseases and develop the infrastructure to conduct infectious disease research, National Institute of Allergy and Infectious Diseases (NIAID) has formed the Emerging Infectious Diseases Research Centers Network (EIDRC-Net). RTI International and Duke University propose to jointly establish the EIDRC-Net Coordination Center to provide overall Network coordination and communication and to build a research infrastructure to help NIAID respond rapidly to infectious disease outbreaks when they occur.","10039433 (contact); 8639782; ","BRAMBILLA, DONALD  (contact); MOODY, MICHAEL ANTHONY;","PATTERSON, JEAN LOIS","05/18/2020","04/30/2025","Address; Affect; Area; Award; Benchmarking; Biological Assay; Biology; career; Central Africa; Central America; Childhood; cloud based; Collaborations; Communicable Diseases; Communication; Consensus; Coordination and Collaboration; Country; Data; data acquisition; data quality; Disease; Disease Outbreaks; disease transmission; Doctor of Philosophy; electronic data capture system; Emerging Communicable Diseases; Ensure; Epidemic; Event; experience; flexibility; Frequencies; Funding; Geographic Locations; Goals; Health; high risk; Home environment; Human; improved; Infectious Diseases Research; Information Management; Infrastructure; Institutes; International; Joints; Knowledge; Laboratories; Leadership; Location; Logistics; Medical; Medical Research; Mentors; Morbidity - disease rate; mortality; National Institute of Allergy and Infectious Disease; next generation; Performance; Principal Investigator; Privatization; Procedures; Process; programs; Protocols documentation; quality assurance; Reagent; repository; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; response; Scientist; Security; Site; social media; Southeastern Asia; Specialist; Specimen; success; System; Testing; Training; United States; United States National Institutes of Health; Universities; usability; Vaccines; web site; ZIKA; ","Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)","151378","ZAI1","Special Emphasis Panel ","","","01","566800","247914","814714",""
"9964677","U54","CA","5","N","05/18/2020","05/01/2020","04/30/2021","","U54CA209988","","RFA-CA-15-014","5U54CA209988-04","NCI:152479\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","PORTLAND","UNITED STATES","","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","","1897319; ","SPELLMAN, PAUL T.;","","","","4D Imaging; Algorithmic Software; analytical tool; Area; base; Big Data to Knowledge; bioimaging; Biological Models; Biomedical Engineering; biomedical scientist; Cancer Biology; cancer heterogeneity; career; Cells; Collaborations; Communities; computer infrastructure; Computer Models; computerized tools; crowdsourcing; Custom; Data; data portal; data visualization; Databases; data tools; design; Development; Discipline; Education and Outreach; Educational Materials; Educational workshop; Environment; epigenomics; Event; Fostering; Funding; General Population; Generations; genomic data; Genomics; Goals; Heterogeneity; Human Resources; Image; imaging platform; Institution; instrumentation; interdisciplinary collaboration; Interdisciplinary Education; Libraries; Logistics; Malignant Neoplasms; mathematical model; Measurement; Measures; Metadata; Microscopy; Modeling; Modernization; Network-based; oncology; outreach; Phenotype; physical science; Process; programs; Research; Research Personnel; Resources; response; Series; Signal Transduction; single cell sequencing; Site; software development; symposium; Synapses; System; Systems Biology; Techniques; Technology; Therapeutic; therapeutic development; therapy development; tool; Training; training opportunity; transcriptome sequencing; Travel; treatment response; United States National Institutes of Health; user-friendly; Visualization; Visualization software; web interface; web site; Work; ","Outreach Core","209988","ZCA1","Special Emphasis Panel ","8357","","04","104999","47480","","152479"
"9974481","R21","AR","5","N","05/18/2020","05/01/2020","04/30/2021","846","R21AR074929","SCHOOLS OF PHARMACY","PAR-18-721","5R21AR074929-02","NIAMS:1\OD:233249\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","Aurora","UNITED STATES","PHARMACOLOGY","06","041096314","US","1199905","UNIVERSITY OF COLORADO DENVER","CO","800452571","Sulfur mustard (SM), the most widely used chemical warfare agent, and nitrogen mustard (NM) are strong alkylating agents causing DNA damage as well as oxidative damage leading to the activation of several molecular pathways. This application will investigate in detail the effect of SM and NM exposure on miRNA changes in the skin tissue. Outcomes are anticipated to establish miRNA signatures, which can serve as novel diagnostic biomarkers and open a new avenue of miRNA-targeted treatment of skin complications following SM and NM exposure.","1865330; ","AGARWAL, RAJESH ;","TSENG, HUNG H","07/08/2019","04/30/2021","Acute; Affect; Alkylating Agents; Automobile Driving; base; Bulla; Cell Death; Chemical Warfare Agents; Chronic; Collagen; Complex; Conditioned Reflex; Cutaneous; cytokine; Cytokine Signaling; Data; Deposition; design; diagnostic biomarker; DNA Damage; Dose; Erythema; Exposure to; FGF2 gene; Fibrosis; Gene Expression; Genes; Immune response; Impaired wound healing; Inbred HRS Mice; Inflammation; Inflammatory; Inflammatory Response; Interleukin-1 beta; Interleukins; Lead; Lesion; Mechlorethamine; Mediator of activation protein; Medical; MicroRNAs; Modeling; Molecular; Mus; Mustard; Mustard Gas; novel diagnostics; novel marker; Organ; Outcome; oxidative damage; Oxidative Stress; Pathology; Pathway Analysis; Pathway interactions; Pigmentation physiologic function; Population; programs; Quality of life; Reporting; response; RNA; Role; Scheme; Signal Pathway; Skin; skin disorder; Skin injury; skin lesion; Skin Tissue; Skin wound; targeted treatment; TNF gene; Ulcer; Untranslated RNA; Vascular Endothelial Growth Factors; Vesicants; Wound Healing; ","MicroRNAs in Skin Inflammation and Wounding by Mustard Vesicants.","074929","ZRG1","Special Emphasis Panel ","","","02","150000","83250","233250",""
"9942509","R21","MH","5","N","05/18/2020","04/01/2020","03/31/2021","242","R21MH120349","SCHOOLS OF MEDICINE","PA-18-400","5R21MH120349-02","NIMH:197804\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PORTLAND","UNITED STATES","PEDIATRICS","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","PROJECT NARRATIVE Mobile health (mHealth) autism screening tools may be an innovative means of improving early access to ASD care; however, low-income and minority families may face special challenges using this technology. In this research proposal, we will examine quality features of existing mHealth autism screening tools; collect qualitative and quantitative user data from low-income/minority parents and community providers to understand barriers to use; and conduct qualitative interviews with screener tool developers to understand challenges in developing tools that meet the needs of the underserved. This research will be used to develop guidelines for mHealth autism screening tools that can effectively reduce autism disparities.","9214414; ","ZUCKERMAN, KATHARINE ELIZABETH;","PINTELLO, DENISE","06/05/2019","03/31/2021","Academy; Address; adverse outcome; Age; American; Attention; autism spectrum disorder; base; Capital; Caring; Child; cognitive load; Communities; Cultural Sensitivity; Data; design; Development; disparity reduction; early childhood; Early Diagnosis; Early identification; Early treatment; Electronic Health Record; Ensure; ethnic minority population; experience; Face; Family; Family health status; Feedback; Funding; Future; Goals; Guidelines; handheld mobile device; health disparity; Health Services Accessibility; Health Technology; Healthcare; improved; income disparities; Individual; Informatics; innovation; Intervention; Interview; Investments; Knowledge; Language; Lead; literacy; Low income; lower income families; Medical; medically underserved; meetings; mHealth; Minority; mobile computing; Mobile Health Application; Mothers; multidisciplinary; Multimedia; next generation; Outcome; Parents; Participant; Pediatrics; Personal Health Records; Pilot Projects; Population; Population Group; Private Sector; Provider; racial and ethnic; racial and ethnic disparities; Research; Research Personnel; Research Proposals; safety net; Sampling; screening; Screening procedure; Services; Tablets; Technology; technology development; Test Result; Testing; tool; tool development; Training; Underserved Population; United States National Institutes of Health; usability; Work; World Health Organization; ","Assessing Usability of mHealth Autism Screeners in the Medically Underserved","120349","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","","02","139115","58689","197804",""
"9918427","T32","HD","5","N","05/22/2020","05/01/2020","04/30/2021","865","T32HD040372","SCHOOLS OF MEDICINE","PA-16-152","5T32HD040372-19","NICHD:386509\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","DURHAM","UNITED STATES","ANATOMY/CELL BIOLOGY","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","An interactive environment, including collaborations with clinical departments, fosters novel discoveries that improve our understanding of diseases and disabilities and can translate to treatments that improve human health, reduce illness and disability, and lengthen life.","9342643; ","SILVER, DEBRA ;","MUKHOPADHYAY, MAHUA","05/01/2001","04/30/2022","Development; stem cell biology; Training Programs; ","Training Program in Developmental & Stem Cell Biology","040372","ZHD1","Special Emphasis Panel ","","","19","367360","19149","386509",""
"9670185","D43","TW","5","N","05/19/2020","03/01/2020","02/28/2021","989","D43TW008650","SCHOOLS OF VETERINARY MEDICINE","PAR-14-193","5D43TW008650-08","FIC:256793\","OTHER RESEARCH-RELATED","2020","FOGARTY INTERNATIONAL CENTER","","COLUMBUS","UNITED STATES","VETERINARY SCIENCES","03","832127323","US","6218701","OHIO STATE UNIVERSITY","OH","432101016","We propose to strengthen and sustain our international Research Training Program shared between The Ohio State University and Institutes of Higher Learning in East Africa. The specific mission of the proposed program is to train the future researchers and trainers using an integrated multi-disciplinary 'One Health' approach. The ultimate goal is to establish sustainable critical mass of capable scientists that can effectively conduct research on zoonotic diseases and implement prevention and control systems.","8865386 (contact); 7727569; 9793286; ","GEBREYES, WONDWOSSEN A (contact); KARIUKI, SAMUEL M; WANG, SHU-HUA ;","SINA, BARBARA J","06/01/2010","02/28/2023","Address; Africa; Africa South of the Sahara; African; Animals; Antimicrobial Resistance; Area; Collaborations; Development; Diagnostic; digital; Discipline; Disease; Doctor of Philosophy; Eastern Africa; Environmental Health; Ethiopia; Food; foodborne; foodborne pathogen; Future; Genomics; Goals; Health; implementation science; Infectious Diseases Research; Institutes; International; Kenya; Laboratories; Leadership; Learning; Leishmaniasis; Measures; Mission; Molecular Epidemiology; Morbidity - disease rate; mortality; multidisciplinary; Ohio; Physicians; pre-doctoral; Prevention; programs; Public Health; Research; Research Personnel; Research Training; Rotavirus; Salmonella infections; Scientist; success; System; Tanzania; Training; Training Programs; Tuberculosis; Universities; Vector-transmitted infectious disease; Veterinarians; Viral; waterborne; waterborne pathogen; Zoonoses; ","Sustainable One Health Research Training Capacity: Molecular Epidemiology of Zoonotic Foodborne and Waterborne Pathogens in Eastern Africa","008650","ZRG1","Special Emphasis Panel ","","","08","250000","6793","256793",""
"9928513","R01","MH","5","N","05/22/2020","05/01/2020","04/30/2021","242","R01MH115765","SCHOOLS OF PUBLIC HEALTH","PA-17-106","5R01MH115765-03","NIMH:586583\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","ANN ARBOR","UNITED STATES","MISCELLANEOUS","12","073133571","US","1506502","UNIVERSITY OF MICHIGAN AT ANN ARBOR","MI","481091276","Transgender women (i.e., individuals with a feminine and/or female gender identity who were assigned male at birth) are disproportionately affected by HIV and transmission risk has been attributed to a primary partnership with a non-transgender male. The overarching goal of this proposal is to test the efficacy of our promising couples-focused HIV prevention intervention to reduce HIV transmission risk among transgender women and their primary male partners by integrating biomedical and behavioral risk reduction strategies to help couples chose the most appropriate HIV prevention plan for their relationship.","12058325 (contact); 2680838; 9421939; ","GAMAREL, KRISTINE E (contact); OPERARIO, DON ; SEVELIUS, JEANNE M.;","ALLISON, SUSANNAH","07/15/2018","04/30/2023","Address; Adherence; Adult; Affect; AIDS prevention; antiretroviral therapy; Anus; arm; base; Behavioral; Biological; Birth; Blood; Caring; Categories; Centers for Disease Control and Prevention (U.S.); Communication; Communities; condoms; Consultations; Control Groups; coping; Couples; Cultural Sensitivity; Data; disparity reduction; efficacy testing; Enrollment; Evidence based intervention; experience; Feedback; Female; Feminine; follow-up; Gays; Gender; Gender Identity; gender minority; Gender Sensitivity; Goals; Grant; Health behavior; Heterosexuals; high risk; HIV; HIV diagnosis; HIV Infections; HIV risk; HIV Seronegativity; HIV Seropositivity; Human immunodeficiency virus test; Individual; Intervention; intervention effect; intervention program; Joints; male; Measures; Mediation; Mediator of activation protein; medication compliance; men who have sex with men; Methodology; Minority; Modeling; Outcome; Outcome Study; Participant; Population; pre-exposure prophylaxis; Prevalence; Prevention program; prevention service; Prevention strategy; Preventive Intervention; primary outcome; Problem Solving; programs; racial diversity; Randomized; Randomized Controlled Trials; recruit; Reporting; Research; Research Personnel; Risk; Risk Behaviors; Risk Reduction; Science; Self Efficacy; sex; Sex Behavior; sexual risk behavior; Sexually Transmitted Diseases; skills; social; social factors; social stigma; social structure; Spottings; standard of care; Stress; Structure; Surveys; Testing; theories; therapy adherence; Time; transgender; transgender women; transmission process; Treatment outcome; United States; Unsafe Sex; uptake; Vagina; Viral; Viral Load result; Work; ","A couples-based approach to HIV prevention for transgender women and their male partners","115765","BSPH","Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section ","","","03","560880","25703","586583",""
"10146190","UM1","AI","3","N","05/18/2020","05/18/2020","11/30/2020","855","UM1AI068636","SCHOOLS OF MEDICINE","PA-20-135","3UM1AI068636-14S1","NIAID:9811257\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","INTERNAL MEDICINE/MEDICINE","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","Project Narrative A5395 is a multicenter study that will be initially limited to and conducted at US ACTG Clinical Research Sites (CRS) based on the local incidence of COVID-19. This study aims to understand whether Hydroxychloroquine (HCQ) and Azithromycin (Azithro) will prevent hospitalization and death in persons with symptomatic SARS- CoV-2 infection.","6297517 (contact); 1944892; ","CURRIER, JUDITH S. (contact); ERON, JOSEPH J.;","OJUMU, AKINLOLU O","05/18/2020","11/30/2020","2019-nCoV; acute care; Adrenal Cortex Hormones; Adverse event; Age; AIDS clinical trial group; Antiviral Agents; Antiviral Therapy; Azithromycin; base; Biological Markers; Cardiac; Caring; Cessation of life; Chemistry; China; Clinical Data; Clinical Research; clinical research site; Clinical Trials; Clinical Trials Cooperative Group; comorbidity; COVID-19; Detection; Development; Disease; Disease Outbreaks; Emergency Situation; Ethnic Origin; experience; Frequencies; Health; Hematology; Hospitalization; Hospitals; Hour; human coronavirus; human disease; Hydroxychloroquine; In Vitro; Incidence; Infection; Inflammatory; interest; Interferons; International; Leadership; Lopinavir; Measures; Methyltransferase; Modeling; Multicenter Studies; Names; Nose; novel; novel therapeutics; operation; Outcome; outcome prediction; Outpatients; Participant; Patient Self-Report; Patients; Peptide Hydrolases; Persons; Placebos; Plasma; Pneumonia; Polymerase; Population; pre-clinical; prevent; Proteins; public health emergency; Quarantine; Race; randomized placebo controlled trial; Regulation; Reporting; Ribavirin; Risk; Ritonavir; RNA; Safety; SARS coronavirus; Severities; sex; Site; Special Event; study population; Subgroup; Swab; Symptoms; targeted treatment; Testing; Therapeutic Agents; treatment group; United States; United States Dept. of Health and Human Services; Viral; Virus; World Health Organization; ","Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/","068636","","","","S1","14","9781973","29284","9811257",""
"10143716","R01","AI","3","N","05/18/2020","05/18/2020","08/31/2020","855","R01AI132404","SCHOOLS OF MEDICINE","PA-18-591","3R01AI132404-03S1","NIAID:37607\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","PORTLAND","UNITED STATES","OTHER BASIC SCIENCES","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","PROJECT NARRATIVE The current COVID-19 pandemic is a global health emergency, causing severe respiratory disease requiring hospitalization and even death in a significant proportion of the human population. Here, we will evaluate whether Vaccinia virus vectors expressing modified versions of the SARS-CoV-2 Spike protein generate high- affinity neutralizing antibodies against the virus. These studies will contribute to the long-term goal of developing an effective vaccine that will prevent the continued spread and seasonal recurrence of this disease within the human population.","10251417; ","NOLZ, JEFFREY CHARLES;","LAPHAM, CHERYL K","05/18/2020","08/31/2021","2019-nCoV; adaptive immune response; adaptive immunity; Adjuvant; Affinity; Antigen Targeting; Antigens; Attenuated; B-Lymphocytes; CD4 Positive T Lymphocytes; Cessation of life; COVID-19; design; Development; Disease; Engineering; FDA approved; Future; Generations; global health emergency; Goals; Hospitalization; Human; Immune Sera; immunogenicity; Immunoglobulin Class Switching; Immunoglobulin Somatic Hypermutation; Immunoglobulin Switch Recombination; in vivo; Infection; Infection prevention; interest; Laboratories; Lung diseases; Membrane Proteins; Military Personnel; Modified Vaccinia Virus Ankara; Morbidity - disease rate; mortality; National Institute of Allergy and Infectious Disease; neutralizing antibody; novel; novel vaccines; pandemic disease; pathogen; Pathway interactions; Patients; Pharmacologic Substance; Plasma Cells; Polysaccharides; Population; prevent; Prevention; Production; Proteins; Publishing; Recombinants; Recurrence; SARS coronavirus; Smallpox; Smallpox Vaccine; Structure of germinal center of lymph node; T memory cell; theories; Therapeutic Intervention; trafficking; United States; Vaccination; vaccine candidate; Vaccines; Vaccinia virus; vaccinia virus vector; Viral; Viral Antigens; Viral Vector; Virus; ","REGULATION OF MEMORY T CELL TRAFFICKING BY CORE 2 O-GLYCAN SYNTHESIS","132404","","","","S1","03","24420","13187","37607",""
"9934253","K01","MH","5","N","05/20/2020","05/01/2020","04/30/2021","242","K01MH112436","SCHOOLS OF MEDICINE","PA-14-044","5K01MH112436-04","NIMH:188223\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","LA JOLLA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","Project Narrative In sub-Saharan Africa, women?s risk of HIV, as well as their access to testing and treatment, is strongly influenced by social-structural forces such as gender inequality, poverty, and stigma. This grant will provide the candidate with advanced training to combine qualitative, quantitative, and geospatial methods to explore how social-structural forces manifest in the spaces where high-risk women in Tanzania live, work, and access healthcare, and how these spaces in turn affect HIV testing and treatment. Findings from this work will inform the development of geographically targeted and spatially tailored interventions to improve HIV prevention, testing, and treatment for high-risk women in sub-Saharan Africa.","14151638; ","FIELDING-MILLER, REBECCA KATHLEEN;","GREENWOOD, GREGORY","05/24/2017","04/30/2022","Address; Affect; Africa South of the Sahara; Age; AIDS prevention; alcohol misuse; Alcohols; antiretroviral therapy; Area; Automobile Driving; Awareness; base; care outcomes; Caring; Characteristics; Client; Clinic; cohesion; Communities; condoms; Counseling; Data; design; Development; Disease; Ecology; Economics; empowerment; Ensure; Environment; epidemiology study; Equation; Evaluation; experience; Face; female sex worker; food insecurity; Forcible intercourse; Funding; Gender; Geographic Information Systems; Geographic Locations; Geography; Goals; Grant; health care availability; health care service; Healthcare; High Risk Woman; HIV; HIV risk; Hot Spot; Human immunodeficiency virus test; Imprisonment; improved; Incidence; Individual; Inequality; Intervention; K-Series Research Career Programs; Left; Legal; Link; Maps; medication compliance; Mentors; Methodology; Methods; Modeling; National Institute of Mental Health; novel; Outcome; Parents; Participant; Pattern; Police; Population; Positioning Attribute; Poverty; preference; Prevalence; programs; racism; Reporting; reproductive; Research; Research Infrastructure; Research Methodology; residence; Resources; Risk; scale up; Scientist; Services; sex; skills; social; social cohesion; social stigma; social structure; Spottings; Structure; success; Tanzania; Testing; Time; Training; United States National Institutes of Health; Violence; Viral; Woman; Work; young woman; ","Social-structural and spatial determinants of HIV testing and linkage to care among high risk women in Tanzania","112436","BSPH","Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section ","","","04","174281","13942","188223",""
"9991183","F30","MH","1","N","05/04/2020","05/04/2020","05/03/2021","242","F30MH122157","SCHOOLS OF MEDICINE","PA-19-191","1F30MH122157-01A1","NIMH:50520\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","NEW YORK","UNITED STATES","INTERNAL MEDICINE/MEDICINE","12","060217502","US","1514803","WEILL MEDICAL COLL OF CORNELL UNIV","NY","100654805","Project Narrative The proposed research is relevant to public health because the neural bases of facial expression production are uniquely vital to social and emotional well-being in human daily life, and are altered in neuropsychiatric dis- orders characterized by socioemotional deficits, such as autism spectrum disorder, schizophrenia, mood disor- ders, and amimia. By determining how the brain produces this critical social signal, the proposed research is relevant to NIMH?s strategic objective of defining mechanisms of complex behavior in order to transform the understanding and treatment of mental illnesses.","14175889; ","IANNI, GEENA ;","VAN'T VEER, ASHLEE V","05/04/2020","05/03/2024","Affective; Anatomy; Area; autism spectrum disorder; base; Behavior; Behavioral; Biological Models; Body part; Brain; Brain region; career; Categories; Cells; Characteristics; Clinical; Code; Communication; Complex; Data; Disease; Dissociation; Doctor of Philosophy; Electrodes; Emotions; Expressed Emotion; Face; Facial Expression; Facial Expression Perception; Facial Muscles; Facial nerve nucleus; Fellowship; Fill-It; Food; Functional Magnetic Resonance Imaging; Goals; Human; human data; innovation; Lateral; Life; Macaca; Magnetic Resonance; Maps; Measures; Medial; medical schools; Mental disorders; Methodology; Methods; microstimulation; Monitor; Monkeys; Mood Disorders; Motivation; Motor; Motor Neurons; Movement; Muscle; National Institute of Mental Health; neural circuit; neural model; neuromechanism; Neurons; neurophysiology; neuropsychiatric disorder; Neuropsychology; Neurosciences; novel; Outcome; peer; Physicians; Population; Primates; Production; programs; Property; Public Health; receptive field; relating to nervous system; Research; Resolution; Schizophrenia; Scientist; Signal Transduction; skills; social; social communication; Social Controls; Social Environment; Social Network; Social Well-Being; Societies; spatiotemporal; Specificity; Stereotyping; Stimulus; Suggestion; System; Testing; Time; Training; Universities; Update; Ursidae Family; Vocabulary; Volition; Well in self; Work; ","'Cortical control of facial expression production'","122157","ZRG1","Special Emphasis Panel ","","A1","01","50520","","50520",""
"10142165","U19","AI","3","N","05/18/2020","05/18/2020","11/30/2020","855","U19AI089992","SCHOOLS OF MEDICINE","PA-18-591","3U19AI089992-09S3","NIAID:695543\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW HAVEN","UNITED STATES","NEUROLOGY","03","043207562","US","9420201","YALE UNIVERSITY","CT","065208327","Narrative In depth immunoprofiling of COVID-19 patients to identify critical elements of the immune responses to the corona virus SARS-Co-V-2.","1877832 (contact); 1924351; ","HAFLER, DAVID A. (contact); MONTGOMERY, RUTH R;","DONG, GANG","05/18/2020","11/30/2021","Antiviral Agents; Aspirate substance; Bioinformatics; Cells; cohort; Cohort Studies; Core Facility; COVID-19; Critical Pathways; Development; Disease; DNA sequencing; Elements; endotracheal; Enrollment; Genetic Transcription; Immune response; Immunophenotyping; metabolomics; Pathogenesis; Patients; Phenotype; Proteomics; Protocols documentation; Resistance; response; sample collection; Sampling; SARS coronavirus; Serum; Therapeutic; Time; transcriptome sequencing; Vaccines; Virus; ","Immunophenotyping for COVID-19 Cohort (IMPACC)","089992","","","","S3","09","428548","266995","695543",""
"9921206","F31","HL","5","N","04/29/2020","05/17/2020","05/16/2021","837","F31HL147394","SCHOOLS OF ARTS AND SCIENCES","PA-18-671","5F31HL147394-02","NHLBI:45520\","TRAINING, INDIVIDUAL","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","HOUSTON","UNITED STATES","PSYCHOLOGY","02","050299031","US","9291001","RICE UNIVERSITY","TX","770051827","Project Narrative  The proposed study is clinically relevant to public health in that it will improve understanding of individual risk factors for cardiovascular disease in bereaved adults by investigating how the ability to regulate emotion is related to inflammation, a biological outcome central in all phases of heart disease. Importantly, the ability to regulate emotion is vital for healthy coping and predictive of health outcomes, and thus, results of the present observational work may yield important information related to the development or revision of existing clinical interventions for bereaved individuals targeting disease prevention. These goals are directly in line with the National Heart, Lung, and Blood Institute's mission to promote heart, lung, and blood treatment and disease prevention to increase longevity; in the present work, the degree of variance in emotion regulatory skills in this vulnerable population may identify resilience factors, illuminate intertwining mechanisms of emotion and inflammation, and shed light on potential future effective, low-burden interventions.","15507157; ","SHAHANE, ANOUSHKA D.;","CAMPO, REBECCA A","05/17/2019","05/16/2022","18 year old; Accounting; Address; Adult; Age; anakinra; Back; Bereavement; biobehavior; Biological; Biological Assay; Biological Markers; Blood; blood treatment; C-reactive protein; Cardiovascular Diseases; cardiovascular disorder risk; cardiovascular risk factor; Cessation of life; Climacteric; Clinical; clinically relevant; clinically significant; coping; cytokine; Dependence; depressive symptoms; design; Development; disorder prevention; effective therapy; emotion regulation; Emotional; emotional reaction; Emotions; Equation; Exhibits; experience; Funding; Future; Gender; Goals; Grief reaction; Guilt; Health; Heart; Heart Diseases; Hematological Disease; immune function; Immunologic Factors; improved; indexing; Individual; Inflammation; Inflammatory; Inflammatory Response; Interleukin-10; Interleukin-6; Intervention; Interview; Knowledge; Language; Lesion; Letters; lexical; Light; Linguistics; Link; Longevity; Lung; Mediating; Mental Depression; Mental Health; Methods; Mission; Modeling; Morbidity - disease rate; mortality; mortality risk; National Heart, Lung, and Blood Institute; natural language; Negative Valence; novel; Oral; Outcome; Participant; perceived stress; Persons; Phase; Physical activity; physical conditioning; Physiological; Population; Procedures; psychologic; Psychological Factors; Psychoneuroimmunology; Psychotherapy; Public Health; Questionnaires; Reaction; Research Design; resilience; response; Risk; Role; Serum; skills; sleep quality; Sleeplessness; Spouses; Standardization; Stimulus; Stress; stressor; Structure; TNF gene; Training; Transcript; Vulnerable Populations; Work; ","Psychological and inflammatory biobehavioral mechanisms underlying the association between bereavement and cardiovascular disease","147394","ZRG1","Special Emphasis Panel ","","","02","45520","","45520",""
"10169814","UG4","LM","5","N","05/22/2020","05/01/2020","04/30/2021","","UG4LM012345","","RFA-LM-15-003","5UG4LM012345-05","NLM:292598\","OTHERS","2020","NATIONAL LIBRARY OF MEDICINE","","FORT WORTH","UNITED STATES","","12","110091808","US","6108502","UNIVERSITY OF NORTH TEXAS HLTH SCI CTR","TX","761072699","","12672254; ","BURGARD, DANIEL ERIC;","VANBIERVLIET, ALAN","","","","AOU-CE SUPPLEMENT","012345","ZLM1","Special Emphasis Panel ","9556","","05","218357","74241","","292598"
"9880792","R15","NR","1","N","05/15/2020","05/18/2020","04/30/2022","361","R15NR018965","SCHOOLS OF ARTS AND SCIENCES","PAR-19-134","1R15NR018965-01","NINR:430999\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","HOBOKEN","UNITED STATES","NONE","08","064271570","US","8109201","STEVENS INSTITUTE OF TECHNOLOGY","NJ","070305906","Project Narrative This proposed pilot study addresses the perception of newly diagnosed cancer patients on their initial consultations with oncology providers. Results from these analyses will provide important patient-centered insights into determining how best to incorporate EHR use in oncology settings to improve patient-provider communication of information that is essential for delivering high-quality, patient-centered care. This pilot study will also provide important initial findings and necessary data for future funding applications that will further determine how to best incorporate and design requirements for patient-centered EHR use in outpatient oncology settings with the ultimate goal of enhancing patient-provider communication to optimize patient understanding, trust, engagement of their treatment decisions and ensure the delivery of high-quality, patient- centered cancer care.","12078844; ","ASAN, ONUR ;","BOUGH, KRISTOPHER J","05/18/2020","04/30/2022","Acute; Address; Adherence; Affect; Ambulatory Care Facilities; Appointment; base; burnout; cancer care; Cancer Patient; Caring; Cessation of life; Chronic Disease; Clinic; Clinic Visits; Clinical; Clinics and Hospitals; Clip; Cognitive; Communication; Complex; computerized; Consultations; Consumption; Data; Decision Making; Depersonalization; design; Disadvantaged; Disease; Disease Management; Disease Progression; Electronic Health Record; Emotions; Engineering; Ensure; Funding; Future; Goals; healthy lifestyle; Human; improved; information processing; insight; Interview; Investigation; knowledge base; Label; Literature; Malignant Neoplasms; Medical; Methods; Minor; Modernization; Newly Diagnosed; oncology; Outcome; outcome forecast; Outcome Measure; Outpatients; Participant; patient engagement; patient oriented; Patient-Centered Care; patient-clinician communication; Patient-Focused Outcomes; Patients; Pattern; Perception; Physicians; Pilot Projects; Prevention; primary care setting; Primary Health Care; Process; Professional Burnout; Provider; Psyche structure; racial diversity; Recurrence; Reporting; Research; Risk; Self Efficacy; shared decision making; Short-Term Memory; side effect; Surveys; Symptoms; System; Techniques; Technology; text searching; Time; tool; Transcript; trend; Trust; Video Recording; Visit; Workload; ","Patients Perceptions of Electronic Health Record use during initial oncology outpatient clinic visits","018965","NRCS","Nursing and Related Clinical Sciences Study Section ","","","01","337786","93213","430999",""
"10057852","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI149295","EARTH SCIENCES/RESOURCES","PA-19-053","1R21AI149295-01A1","NIAID:240100\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","STILLWATER","UNITED STATES","BIOCHEMISTRY","03","049987720","US","1450502","OKLAHOMA STATE UNIVERSITY STILLWATER","OK","740781016","Viruses, as obligate intracellular parasites, have evolved strategies to manipulate the cellular membranes for entry, genome replication, virion production, and exit. Uncovering these strategies, such as the one used by poxviruses to acquire their envelope, will not only reveal key viral replication steps for antivirals development but also provide mechanistic insights on fundamental cellular processes. The study on the protein machinery involved in VACV envelope assembly provides a unique opportunity for dissecting the molecular mechanism of cellular membrane scission and remodeling.","9072247 (contact); 7036114; ","DENG, JUNPENG  (contact); XIANG, YAN ;","NATARAJAN, RAMYA","05/22/2020","04/30/2022","alpha helix; Antiviral Agents; Binding; C-terminal; Cell physiology; Cells; Cellular Membrane; Cellular Morphology; Complex; Data; Development; DNA Viruses; Ectopic Expression; Endoplasmic Reticulum; Evolution; Extravasation; Generations; Genome; Goals; Head; hydrophilicity; Hydrophobicity; Individual; innovation; insight; Lipid Bilayers; Lipid Binding; Lipids; Liposomes; Mediating; Membrane; membrane assembly; membrane biogenesis; Modality; Molecular; N Domain; novel; obligate intracellular parasite; Organelles; Permeability; phosphatidylinositol 3-phosphate; phosphatidylinositol 4-phosphate; Phospholipids; Poxviridae; Process; Production; Proteins; Publications; Reporting; Roentgen Rays; Role; Structure; Tail; Testing; Vaccinia virus; Viral; Viral Proteins; Virion; Virus; virus envelope; Virus Replication; X-Ray Crystallography; ","Structure function studies of a molecular complex for generating viral membrane","149295","VIRA","Virology - A Study Section ","","A1","01","190500","49600","240100",""
"9868868","P01","AG","5","N","05/18/2020","03/01/2020","02/28/2021","","P01AG009524","","PAR-13-258","5P01AG009524-25","NIA:261643\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","TAMPA","UNITED STATES","","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","PUBLIC HEALTH RELEVANCE NARRATIVE- Project 2 This project is designed to develop and advance innovative approaches for amelioration of age-related hearing loss (ARHL) ? a highly prevalent neurodegenerative condition and communication disorder affecting nearly 70% of Americans over the age of 70. Using behavioral methods with animal models, we will evaluate a promising hormone intervention (aldosterone) to improve inner ear and brain function, develop novel interventions to improve hearing function using special sounds called augmented acoustic environments (AAEs), and evaluate new interventions for the treatment of maladaptive plasticity in the aged central auditory system following peripheral hearing loss. The findings will be integrated with those of sister projects for maximum health benefit impact.","2098075; ","WALTON, JOSEPH P;","","","","Acoustics; Address; Advanced Development; Affect; Age; age effect; age related; aged; Aging; aging auditory system; Aldosterone; American; Animal Behavior; Animal Model; Anti-Inflammatory Agents; Auditory; Auditory system; Auditory Threshold; base; Behavior; behavior test; Behavioral; Bilateral; Biological Aging; Biological Markers; Biological Response Modifier Therapy; Brain; CBA/CaJ Mouse; Chronic; clinical practice; Cochlea; Communication; Communication impairment; design; Detection; Ear; Environment; Exhibits; experimental study; Exposure to; Goals; Health Benefit; Hearing; hearing impairment; Hormones; Human; Impairment; improved; innovation; insight; Intervention; Labyrinth; Link; Longevity; Measures; Methods; Midbrain structure; middle age; Modeling; Modification; Molecular; mouse model; Mouse Strains; Mus; Nerve Degeneration; Neural Inhibition; Neuronal Plasticity; neurophysiology; Noise; normal hearing; Normal Range; novel; Perception; Performance; performance tests; Peripheral; Plug-in; prepulse inhibition; Presbycusis; Program Research Project Grants; programs; public health relevance; Reflex action; relating to nervous system; repetitive transcranial magnetic stimulation; Research; response; Role; Salicylic Acids; Sensorineural Hearing Loss; Serum; Signal Transduction; Sister; sound; speech in noise; Speech Intelligibility; speech processing; Startle Reaction; stem; Supplementation; targeted treatment; Testing; Therapeutic Intervention; therapy design; Transcranial magnetic stimulation; Translational Research; treatment effect; United States National Institutes of Health; Vision; ","Project 2 - Animal Behavior","009524","ZAG1","Special Emphasis Panel ","5994","","25","178417","83226","","261643"
"10159111","I01","VA","5","N","05/17/2020","03/01/2020","02/28/2021","999","I01HX002443","","RFA-HX-17-005","5I01HX002443-03","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","INDIANAPOLIS","UNITED STATES","","07","608434697","US","481029","RLR VA MEDICAL CENTER","IN","462022803","Cognitive- behavioral therapy for chronic pain (CBT-CP) is an evidence-based practice that is considered central to the treatment of pain; the Veteran's Health Administration has invested in system-wide training and certification for CBT-CP. Despite this substantial investment, practically nothing is known about the implementation of CBT-CP following initial training and certification. Based on implementation of other EBPs, there is good reason to believe that modification occurs frequently, with unknown impact on quality of Veterans' care. Our project will include a VHA-Wide survey of CBT-CP providers that will assess common modifications made to CBT-CP in the field (Aim 1). This survey will also be used to identify what motivates providers to modify CBT-CP (Aim 2) and the effects of modification on Veteran outcomes (Aim 3a) and CBT- CP implementation (Aim 3b).","10718851; ","MCGUIRE, ALAN BENJAMIN;","","03/01/2018","02/28/2022","Adoption; Affect; Attenuated; base; Behavior; Behavior Therapy; behavioral health intervention; Caring; Certification; chronic pain; Code; Cognitive Therapy; Consultations; Data; disability; Drops; Effectiveness; Ensure; Evidence based practice; follow-up; Goals; health administration; Healthcare Systems; implementation strategy; improved; Interview; Investments; lens; Maintenance; Medical; Modeling; Modification; Motivation; Nature; Observational Study; Opioid; Outcome; Pain; Pain management; pain outcome; Participant; Patient Self-Report; Planning Theory; prevent; programs; prospective; Provider; psychosocial; Quality of Care; recruit; Resources; Respondent; response; Sampling; Self Determination; Structure; Surveys; System; Telephone; Testing; theories; Training; Typology; Veterans; voltage; wasting; ","Cognitive-Behavioral Therapy for Chronic Pain: do Modifications Affect VEterans or implementatioN (CBT-CP MAVEN)","002443","HS1A","Health Care and Clinical Management ","","","03","","","",""
"9906229","P01","GM","5","N","05/22/2020","04/01/2020","03/31/2021","859","P01GM095467","","PAR-13-280","5P01GM095467-10","NIGMS:1606435\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","PUBLIC HEALTH RELEVANCE:    To improve patient care, a goal of this program project is to harness specialized pro- resolving mediators (SPMs) and their bioactive SPM-sulfido conjugates that we recently discovered for resolution pharmacology. This is a novel therapeutic approach to better treat human diseases and tissue injury where uncontrolled infectious inflammation and tissue regeneration are important. The potential for resolution pharmacology as a new therapeutic approach could diminish the healthcare consequences of uncontrolled prolonged infectious inflammation and tissue damage.","1887763; ","SERHAN, CHARLES NICHOLAS;","GARCIA, MARTHA","04/01/2011","03/31/2021","Acute; Address; Anabolism; Animal Disease Models; Anti-inflammatory; Back; Biological Models; CD59 Antigen; Cell Communication; Chemicals; Chemotactic Factors; Clinic; clinical practice; counterregulation; Coupled; Critical Pathways; Epithelial Cells; Exudate; Family; Goals; Healthcare; Histology; Homeostasis; Host Defense; Human; human disease; human tissue; improved; indexing; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; instrument; interdisciplinary approach; Invaded; Knowledge; Leukocytes; Leukotrienes; lipid mediator; Lipoxins; Mediator of activation protein; metabolome; microbial; Mission; Molecular; multidisciplinary; Natural regeneration; Nosocomial Infections; novel; novel therapeutic intervention; Operative Surgical Procedures; Organ; Organic Synthesis; Organism; Outcome; Pathway interactions; Patient Care; Peptides; Phagocytes; Pharmacology; Phase; Process; programs; Prostaglandins; Public Health; public health relevance; Recovery; Resolution; Role; Severities; Signal Transduction; Strategic Planning; Structure; Surgical Injuries; Testing; Time; tissue injury; tissue regeneration; Tissues; tool; Trauma; ","Resolution Mechanisms in Acute Inflammation: Resolution Pharmacology","095467","ZGM1","Special Emphasis Panel ","","","10","1011602","594833","1606435",""
"10142693","R01","GM","3","N","05/22/2020","07/01/2019","06/30/2020","859","R01GM068803","SCHOOLS OF MEDICINE","PA-18-591","3R01GM068803-15S2","NIGMS:4739\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","WORCESTER","UNITED STATES","BIOCHEMISTRY","02","603847393","US","850903","UNIV OF MASSACHUSETTS MED SCH WORCESTER","MA","016550002","PROJECT NARRATIVE Cellular growth, development, movement and communication absolutely require accurate vesicle targeting and membrane fusion; an essential component of these fundamental cell biological processes is the exocyst complex, which is conserved from yeast to man, and has been implicated in a variety of human diseases, such as cancer, diabetes, ciliopathies, and bacterial pathogenesis. Our studies of the exocyst and its regulation of membrane fusion proteins will lead to a molecular understanding of the function of the exocyst complex. In addition, our research will also lead to the development of many technologies, constructs, reagents and ideas that will be valuable tools for studying how the exocyst complex regulates secretion in all eukaryotic cells.","1881510; ","MUNSON, MARY ;","AINSZTEIN, ALEXANDRA M","07/01/2005","06/30/2022","Animal Model; Architecture; Auxins; Binding; Biochemical; Biological; Biological Process; biophysical techniques; Biophysics; cell growth; Cell membrane; Cells; Cellular biology; Cellular Morphology; Chimeric Proteins; ciliopathy; Communication; Complex; crosslink; Cryoelectron Microscopy; Crystallography; Data; Development; Diabetes Mellitus; Dissection; Electron Microscopy; Eukaryota; Eukaryotic Cell; Event; Foundations; Funding; Genetic; Golgi Apparatus; Growth; Growth and Development function; Hormones; Human; human disease; improved; In Vitro; in vitro Assay; in vivo; Individual; insight; Investigation; Knowledge; Lead; Liposomes; Malignant Neoplasms; man; Maps; Mass Spectrum Analysis; Measures; Mechanics; Mediating; Membrane; Membrane Fusion; Methods; Modeling; Molecular; Molecular Conformation; molecular modeling; Molecular Structure; Monomeric GTP-Binding Proteins; Movement; multidisciplinary; mutant; Myosin ATPase; Negative Staining; Neurons; neurotransmission; novel; Organelles; Organism; Pathogenesis; Pathway interactions; Plant Roots; Play; Process; protein complex; Proteins; Publishing; Quality Control; rab GTP-Binding Proteins; Reagent; Recycling; Regulation; Research; Resolution; rho GTP-Binding Proteins; Role; Saccharomyces cerevisiae; Secretory Vesicles; single molecule; Site; SNAP receptor; Specificity; Spectrum Analysis; Structure; System; Techniques; Technology; Testing; three dimensional structure; Time; tool; trafficking; Vesicle; vesicle transport; Yeast Model System; Yeasts; ","Structure and Function of the Exocyst Complex","068803","","","","S2","15","2829","1910","4739",""
"9933893","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:229399\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1917368; ","MCGUINNESS, OWEN P;","","","","Abbreviations; Academic Medical Centers; Address; Amino Acids; Area; Awareness; Biological; Biological Assay; Contract Services; Controlled Environment; cost; Cost Analysis; cytokine; Diabetes Mellitus; Equipment; experience; Fee-for-Service Plans; Glucose; Hormones; Human Resources; improved; In Vitro; in vivo; Individual; innovation; instrumentation; interest; Laboratories; Lipids; Lipoproteins; Liquid substance; Measurement; Measures; Metabolic; Metabolism; method development; Methods; Modernization; Nucleotides; Obesity; oxidant stress; Oxidative Stress; Physiology; Plasma; Postdoctoral Fellow; Procedures; Process; Productivity; programs; Protocols documentation; Reagent; Reproducibility; Research; Research Assistant; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Running; Sampling; service utilization; Services; Standardization; Students; Technology; Tissue Sample; Training and Education; Translations; Universities; Wages; Work; ","Hormone Assay and Analytical Services Core","020593","ZDK1","Special Emphasis Panel ","7646","","43","164533","64866","","229399"
"9852899","P20","GM","1","N","05/21/2020","12/01/2019","11/30/2020","","P20GM130448","","PAR-18-266","1P20GM130448-01A1","NIGMS:271107\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MANHATTAN","UNITED STATES","","01","929773554","US","4202801","KANSAS STATE UNIVERSITY","KS","665062504","","15359136; ","MOROZOV, IGOR ;","","","","Animal Experimentation; Animal Experiments; animal facility; Animal Model; Animals; Antibodies; Area; Autopsy; Award; Biomedical Research; biosafety level 3 facility; biosecurity; Caring; Centers of Research Excellence; college; Communicable Diseases; comparative; Consultations; Containment; Core Facility; Development; Diagnostic; Diagnostic tests; Ensure; Equipment; Evaluation; Experimental Designs; Experimental Pathology; experimental study; Extramural Activities; Funding; Goals; Hybridomas; IACUC; Immune Sera; improved; Individual; Infrastructure; instrument; Investigation; Kansas; laser capture microdissection; Medicine; Methodology; Modeling; Molecular and Cellular Biology; pathogen; Pathologic; Pathologist; Pathology; Performance; Pilot Projects; Process; Protocols documentation; Reagent; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Reservations; Rodent; sample collection; Sampling; Schedule; Seeds; Services; single-cell RNA sequencing; success; synergism; System; Testing; Time; TimeLine; Tissue Banks; Tissue Sample; Training; Universities; Vertebrates; Veterinary Medicine; Work; Zoonoses; ","Animal Model/Pathology Core","130448","ZGM1","Special Emphasis Panel ","7577","A1","01","178360","92747","","271107"
"9949728","T32","HD","5","N","05/22/2020","05/01/2020","04/30/2021","865","T32HD007502","SCHOOLS OF MEDICINE","PA-16-152","5T32HD007502-23","NICHD:266760\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","Nashville","UNITED STATES","ANATOMY/CELL BIOLOGY","05","965717143","US","8721001","VANDERBILT UNIVERSITY","TN","37203","The broad discipline of Developmental Biology has undergone massive alterations over the last few years to include whole-genome level analyses, high-resolution imaging (including real-time on live tissue), and sophisticated genetic techniques, to allow study of behavior and differentiation of single or groups of cells, and in normal or gene-mutated conditions. Developmental Biological studies lead to massive insights into human congenital syndromes, cellular deficits that result in defective organogenesis or specific physiological or homeostatic problems, and how mature cells in the body are destabilized in cancer. This training program selects high quality students from diverse backgrounds, brings them up to speed in the battery of new techniques that can now be applied, and provides them with direct clinical and translational connections to their research, including the skills to move into higher positions doing research directly relevant to human biology and disease, or to move into industrial or teaching positions.","1901653; ","WRIGHT, CHRISTOPHER V;","MUKHOPADHYAY, MAHUA","05/01/1997","04/30/2023","Developmental Biology; regenerative; Stem cells; Training Programs; ","Training Program in Stem Cell and Regenerative Developmental Biology","007502","ZHD1","Special Emphasis Panel ","","","23","276120","14410","266760",""
"10110992","R15","EB","7","N","05/21/2020","05/14/2020","04/30/2021","286","R15EB024283","BIOMED ENGR/COL ENGR/ENGR STA","PA-18-590","7R15EB024283-02","NIBIB:182100\","Non-SBIR/STTR RPGs","2018","NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING","","OREM","UNITED STATES","BIOSTATISTICS & OTHER MATH SCI","03","073076952","US","514008","UTAH VALLEY UNIVERSITY","UT","840586703","Narrative:  CT dose is currently a major concern for the general public. Low-dose CT is under development. The proposed research will focus on developing fast, robust and practical image reconstruction methods that are able to produce a standard CT image using a lower CT dose.","14365586; ","ZENG, GENGSHENG ;","ZUBAL, IHOR GEORGE","05/01/2018","04/30/2021","","Fast and Robust Low-Dose X-Ray CT Image Reconstruction","024283","ZRG1","Special Emphasis Panel ","","","02","151842","30258","182100",""
"10149948","F32","AR","5","N","05/21/2020","11/16/2019","11/15/2020","846","F32AR073649","SCHOOLS OF MEDICINE","PA-16-307","5F32AR073649-04","NIAMS:69306\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","CHAPEL HILL","UNITED STATES","PHYSIOLOGY","04","608195277","US","578206","UNIV OF NORTH CAROLINA CHAPEL HILL","NC","275990001","Project Narrative Proper kidney function relies on podocytes and the architecture created by their interdigitating membrane structures, termed foot processes. Compromise to podocyte integrity is a common clinical observation in kidney disease. We aim to test and identify the podocyte foot process proteome in development and disease.","12045236; ","GERLACH, GARY FREDERICK;","TSENG, HUNG H","12/01/2018","11/15/2021","Affinity; Architecture; Asses; base; Basement membrane; Beta Cell; Biological Assay; Biological Models; Biotin; blood filter; candidate validation; Cell Culture Techniques; Cells; Clinical; comparative; Comparative Study; Complex; CRISPR/Cas technology; Data; Development; Diabetic Nephropathy; Disease; Disease model; Edema; Embryo; End stage renal failure; Endothelium; Engineering; Etiology; Fertilization; Filtration; flexibility; foot; Foot Process; Genes; Genetic; Goals; Histology; Homologous Gene; Hour; Human; human disease; human model; Hyperglycemia; Immunofluorescence Immunologic; in silico; In Vitro; in vivo; Injections; insight; interest; Kidney; kidney cell; Kidney Diseases; Kidney Glomerulus; knock-down; Knock-in; Knock-out; Label; Ligase; Link; Maintenance; Mass Spectrum Analysis; Membrane; Modeling; Molecular; molecular sieving; mouse model; Mus; Mutate; Nephrons; Normal tissue morphology; novel; NPHS2 protein; Pericardial body location; Phenotype; Physiological; Physiology; podocyte; Process; Proteins; Proteome; Proteomics; Renal function; repaired; Role; Sampling; scaffold; screening; slit diaphragm; Streptozocin; Structure; Structure of beta Cell of islet; System; Techniques; Testing; Therapeutic Intervention; Time; Tissues; transcriptomics; Transmission Electron Microscopy; Zebrafish; ","Testing the Podocyte Foot Process Proteome During Development and in Disease","073649","ZRG1","Special Emphasis Panel ","","","04","69306","","69306",""
"10039451","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI153585","SCHOOLS OF MEDICINE","PA-19-053","1R21AI153585-01","NIAID:243606\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SEATTLE","UNITED STATES","PATHOLOGY","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","RELEVANCE After chickenpox due to VZV infection, VZV resides in a latent state for decades before recrudescing in about 30% of persons as zoster, a painful condition that can have medically serious consequences including stroke and blindness. We use stored specimens from persons who were tracked over time for zoster to measure if infection with herpes simplex virus, which shares many structures with VZV that can be recognized by the immune system, is associated with a decreased risk of developing herpes zoster due to cross-reactive immunity.","11505554; 1872996 (contact); ","HARBECKE, RUTH ; KOELLE, DAVID M (contact);","BEISEL, CHRISTOPHER E","05/22/2020","04/30/2022","Address; Adult; Afferent Neurons; Age; Amino Acids; Antibodies; arm; biobank; Biological Assay; Blindness; CD8-Positive T-Lymphocytes; Centers for Disease Control and Prevention (U.S.); Chickenpox; Chickenpox Vaccine; Child; Childhood; Clinical Trials; cohort; Consensus; cross reactivity; Cytomegalovirus; Data; Development; Disease; Distant; Epidemiology; Epstein-Barr Virus Infections; Health; Herpes zoster disease; Herpesviridae; Herpesvirus 1; Herpesvirus Type 3; Human Herpesvirus 2; Human Herpesvirus 4; Human Herpesvirus 6; Human Herpesvirus 7; Immune; Immune system; Immunity; Immunocompetent; Incidence; Infection; Light; Measures; Medical; Morbidity - disease rate; National Health and Nutrition Examination Survey; Nested Case-Control Study; Odds Ratio; Pain; Participant; pathogen; Persons; Placebos; Population; Predisposition; Prevalence; prevent; Prevention; Publications; Randomized Controlled Trials; Recrudescences; repository; Risk; Sampling; Serological; Seroprevalences; Serum; Severities; sex; Simplexvirus; Specimen; Stroke; Structure; T cell response; T-Lymphocyte; T-Lymphocyte Epitopes; Testing; Time; Time trend; trend; United States; Universities; Vaccination; Vaccines; Virus Diseases; Washington; Western Blotting; Zoster Vaccine; ","DOES REDUCED HSV PREVALENCE RESULT IN INCREASED ZOSTER INCIDENCE IN THE US?","153585","CRFS","Clinical Research and Field Studies of Infectious Diseases Study Section ","","","01","162757","80849","243606",""
"9918115","P30","ES","1","N","05/21/2020","05/15/2020","03/31/2021","","P30ES030284","","RFA-ES-18-003","1P30ES030284-01A1","NIEHS:169042\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","15471115; ","CHARLESWORTH, ANNEMARIE ;","","05/22/2020","03/31/2025","Address; Advisory Committees; Award; California; career; Caring; Clinic; Clinical; clinical application; Collaborations; Communication; Communities; community center; Community Health; Complex; Discipline of Nursing; Disease; Education; education resources; Educational Curriculum; Educational Materials; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Medicine; Etiology; Face; Feedback; Foundations; Funding; Future; Goals; Growth; Health; health disparity; Health education; health literacy; Health Professional; Healthcare; Knowledge; Lead; Leadership; Learning; Location; Mainstreaming; Medical Education; medical schools; Medical Students; member; Mentors; Modeling; National Institute of Environmental Health Sciences; NCI Scholars Program; Neighborhood Health Center; Nursing Faculty; Patients; Pilot Projects; Planet Earth; Positioning Attribute; preservation; prevent; Prevention; Professional Organizations; Professional Practice; programs; Public Health; reproductive; Reproductive Health; Research; Research Personnel; Resources; Role; San Francisco; Science; Scientist; Source; Students; Time; tool; Training; Translations; United States National Institutes of Health; Universities; uptake; Work; ","Community Engagement Core","030284","EHS","Environmental Health Sciences Review Committee ","7075","A1","01","104778","64264","","169042"
"9906234","P01","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P01GM095467","","PAR-13-280","5P01GM095467-10","NIGMS:198450\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","","6891980; ","PETASIS, NICOS A;","","","","Acute; Anabolism; analytical method; Area; base; Biological; Biological Process; CD59 Antigen; Chemicals; Chemistry; Collaborations; Complex; design; experience; functional group; Geometry; Goals; improved; In Vitro; in vivo; Inflammation; Investigation; Isotope Labeling; Isotopes; lipid mediator; Mediator of activation protein; Methodology; Methods; milligram; Mission; Nature; novel; Organic Synthesis; Pathway interactions; Pharmacology; physical property; pi bond; programs; Property; Research Support; Resolution; Role; Services; Structure; Synthesis Chemistry; technique development; Techniques; tissue regeneration; ","Core C: Organic Synthesis Core - Total Synthesis of Specialized Pro-Resolving Lipid Mediators","095467","ZGM1","Special Emphasis Panel ","6580","","10","131030","67420","","198450"
"10166606","I01","VA","5","N","05/17/2020","09/01/2019","08/31/2020","999","I01HX001586","","RFA-HX-15-002","5I01HX001586-04","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","PORTLAND","UNITED STATES","","03","089461255","US","481073","PORTLAND VA MEDICAL CENTER","OR","972392964","Cultural competence training has been widely endorsed and adopted as a means to reduce racial disparities in health care delivery, but there has been little evidence to inform what effective training should look like. The purpose of this project is to generate evidence that will shape effective interventions to improve providers' and healthcare teams' ability to work effectively with minority patients, develop strong relationships, and deliver patient-centered care. The study follows from prior work demonstrating that providers' self-assessed cultural competence is associated with better patient-provider interactions and relationships, as perceived by minority veterans. The next step is to understand what providers with higher levels of cultural competence are doing differently to achieve better interactions and relationships. Understanding how cultural competence manifests in patient care interactions will help determine the skills and behaviors that should be targeted in training health professionals in a way that will improve their ability to deliver equitable patient care.  ","8364774; ","SAHA, SOMNATH ;","","09/01/2016","09/30/2021","Address; Adopted; African American; AIDS/HIV problem; American; Attention; Attitude; Audiotape; base; Behavior; care outcomes; care providers; Caring; Clinic; Clinical; Code; Communication; communication behavior; Coupled; cultural competence; Data; Diabetes Mellitus; diabetic patient; Dimensions; disparity reduction; effective intervention; ethnic difference; ethnic minority population; glycemic control; Goals; health care delivery; health care disparity; health care quality; health care service; health care service organization; Health Occupations; Health Personnel; Health Professional; health training; Healthcare; improved; instrument; Intervention; Interview; Maps; Measures; Medical; Medical Care Team; Medical center; member; Methods; Minority; Outcome; Patient Care; patient population; patient response; Patient Self-Report; patient subsets; Patient-Centered Care; patient-clinician communication; Patients; Perception; Phase; Primary Health Care; Process; Professional Organizations; programs; Provider; Quality of Care; Race; racial and ethnic; racial disparity; racial health disparity; racial minority; Reaction; recruit; Reporting; Research; Resources; Sampling; Schools; Self Management; Series; Shapes; Side; skills; Source; Surveys; systematic review; Testing; Time; Training; Training Programs; Transcript; uptake; Variant; Veterans; Visit; Work; ","Opening the Black Box of Cultural Competence","001586","HSR2","HSR-2 Determinants of Patient Response to Care   ","","","04","","","",""
"9976814","U01","TR","1","N","05/18/2020","05/18/2020","04/30/2021","350","U01TR003206","GRADUATE SCHOOLS","PAR-19-099","1U01TR003206-01","NCATS:744816\","Non-SBIR/STTR RPGs","2020","NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES","","NEW YORK","UNITED STATES","BIOCHEMISTRY","12","071037113","US","7056601","ROCKEFELLER UNIVERSITY","NY","100656399","Narrative Partnering with patients and communities is a high priority for researchers, institutions and funding agencies so they can design clinical research studies in ways that optimize research participants? experiences. However, investigators often lack the tools, expertise, and technology to collect the feedback to guide and evaluate these efforts. This project combines the experience, expertise and enthusiasm of investigators and stakeholders at six Clinical Translational Science Awardee institutions to develop new infrastructure that will make it easy to collect, analyze, return, and use research participant experience data to improve research conduct, informed consent, representative enrollment, and to accelerate discoveries in human health.","9425824; ","KOST, RHONDA G.;","BRAZHNIK, OLGA","05/18/2020","04/30/2024","Accreditation; Address; Adoption; Benchmarking; Charge; Clinical; Clinical Research; Collaborations; Collection; Communication; Communities; Consensus; Consent; Custom; dashboard; Data; Data Aggregation; Data Collection; data integration; data interoperability; design; Development; Device or Instrument Development; electronic data; empowered; Enrollment; Equilibrium; Evaluation; evidence base; experience; Feedback; Foundations; Funding Agency; Goals; Grant; Health; Human; improved; Informed Consent; Infrastructure; innovation; Institution; instrument; Leadership; Learning; Libraries; Measures; Metadata; Methods; Mission; mobile computing; Modeling; Motivation; novel; Online Systems; Operations Research; Outcome Measure; Participant; Patients; Perception; Population; Process; programs; Publications; Recommendation; recruit; Research; research and development; Research Infrastructure; Research Personnel; Research Priority; Research Project Grants; research study; Resources; Secure; Site; Specific qualifier value; Standardization; success; Surveys; Technology; Testing; Time; tool; Translational Research; Trust; Universities; Validation; Visualization software; Voice; volunteer; ","Empowering the Participant Voice: Collaborative Infrastructure and Validated Tools for Collecting Participant Feedback to Improve the Clinical Research Enterprise","003206","ZTR1","Special Emphasis Panel ","","","01","570906","173910","744816",""
"9927564","UC7","AI","5","N","05/19/2020","05/01/2020","04/30/2021","","UC7AI094660","","RFA-AI-15-009","5UC7AI094660-10","NIAID:6362733\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","GALVESTON","UNITED STATES","","14","800771149","US","578406","UNIVERSITY OF TEXAS MED BR GALVESTON","TX","775555302","National Biocontainment Laboratories Operational Support ensures the availability of maximum containment laboratories for research that will develop the next generation of therapeutics, diagnostics and vaccines for infectious diseases that can pose a public health risk. It also ensures that high containment labs are available in the event of a public health or bioterrorism emergency. This support is essential due to the high cost of building and maintaining laboratories that protect researchers, ensure the biosecurity of dangerous pathogens, and safeguard the communities where these laboratories are located.","10937968; ","KSIAZEK, THOMAS GARY;","","","","Applied Research; Basic Science; biodefense; biosecurity; Bioterrorism; Communicable Diseases; Communities; Confocal Microscopy; Containment; cost; Dangerousness; Diagnostic; Emergency Situation; Engineering; Ensure; Environmental Health; Equipment and supply inventories; Event; Flow Cytometry; Funding; Goals; hazard; Human Resources; Infectious Agent; Infrastructure; instrumentation; Interdisciplinary Study; Laboratories; laboratory experience; laboratory experiment; laboratory facility; Laboratory Research; Maintenance; Medical; National Institute of Allergy and Infectious Disease; novel therapeutics; operation; pathogen; Postdoctoral Fellow; pre-clinical; Public Health; public health emergency; Regulation; Research; research facility; Research Personnel; Resources; Risk; Secure; Services; Site; Texas; Training; Universities; Vaccines; Waste Management; ","Facility Maintenance and Operation Core - Galveston National Laboratory BSL4 Operations","094660","ZAI1","Special Emphasis Panel ","8720","","10","4458188","1904545","","6362733"
"9918428","T32","HD","5","N","05/22/2020","05/01/2020","04/30/2021","865","T32HD069054","","RFA-HD-16-015","5T32HD069054-10","NICHD:203508\","TRAINING, INSTITUTIONAL","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","CINCINNATI","UNITED STATES","","01","071284913","US","615001","CINCINNATI CHILDRENS HOSP MED CTR","OH","452293039","PUBLIC HEALTH RELEVANCE: The T32 Training Program in Pediatric Clinical Pharmacology provides an outstanding resource for expanding and improving the current critically small pool of pediatric clinical pharmacologists by training the next generation of pediatric clinical investigators to assume leadership roles in developing innovative, high impact clinical and developmental pharmacology related approaches that will improve proper use of medicines in children. This will allow the further enhancement of personalized pediatric therapeutics and ultimately improve the quality of care and related health outcomes of children.","6832073; ","VINKS, ALEXANDER A;","PAWLYK, AARON C","05/16/2011","04/30/2021","Childhood; Clinical Pharmacology; post-doctoral training; Training Programs; ","Cincinnati Pediatric Clinical Pharmacology Postdoctoral Training Program","069054","ZHD1","Special Emphasis Panel ","","","10","234106","17448","203508",""
"10087461","I01","VA","5","N","05/22/2020","01/01/2020","12/31/2020","999","I01BX002714","","RFA-BX-14-001","5I01BX002714-06","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","ST. LOUIS","UNITED STATES","","01","033986766","US","481050","ST. LOUIS VA MEDICAL CENTER","MO","631061621","PUBLIC HEALTH RELEVANCE:         Abdominal aortic aneurysm (AAA) is among the top 20 leading causes of death in the U.S., accounting for ~15,000 deaths per year. Previous studies indicate that as many as 1 in 20 U.S. veterans over the age of 50 have AAA. Open surgical repair of large AAA (greater than 5.5 cm in diameter) is effective in preventing death from ruptured aneurysm. Of the 35,000 operations performed each year to repair AAA 1,200 were performed by the Department of Veterans Affairs according to one study. Although effective, open surgical repair can be associated with high post-operative mortality (up to 6%). Endovascular repair carries lower post-operative mortality risk but does not lead to increased long-term survival among older patients who make up a large percentage of the veterans population. Given the limited treatment options, the advanced age of patients with AAA-which may preclude them from undergoing major surgery-and the uncertainties that still pertain to endovascular repair, there is a need to develop medical treatment approaches that halt disease progression.","1886217; ","PHAM, CHRISTINE T.;","","01/01/2015","12/31/2020","Abdominal Aortic Aneurysm; Accounting; adaptive immune response; Affect; Age; Anaphylatoxins; Aneurysm; Antibodies; Antibody Response; Aorta; Appearance; Atherosclerosis; Attenuated; Autoantibodies; Autoantigens; Autoimmune Process; Autoimmunity; base; Behavior; Binding; biomarker validation; Blood Circulation; Blood Vessels; Caliber; Cause of Death; CD8-Positive T-Lymphocytes; Cell physiology; Cessation of life; Chronic; cigarette smoke; cigarette smoking; citrullinated protein; Complement; Complement 3a; Complement 5a; Complement Activation; Complex; Coronary Arteriosclerosis; Dendritic Cells; design; Development; Dilatation - action; Disease; Disease Progression; Elastases; Elderly; Emergency Situation; Environmental Risk Factor; Epitopes; Event; extracellular; Fibrinogen; Gender; General Population; Generations; Genetic Predisposition to Disease; Genetic Risk; Goals; High Prevalence; Human; human old age (65+); Hypertension; Immune; Immune Targeting; Immunoglobulin G; Immunotherapeutic agent; In Vitro; Individual; Inflammatory; insight; Interferons; Intervention; Investigation; Lectin; Link; macrophage; male; Mannose Binding Lectin; Mediating; Medical; Metalloproteases; Molecular; mortality; mortality risk; mouse model; Mus; neutrophil; Neutrophil Infiltration; older patient; operation; Operative Surgical Procedures; Pathogenesis; Pathogenicity; Pathway interactions; Patients; Pharmacology; Phenotype; Population; Post-Translational Protein Processing; Postoperative Period; Prevalence; prevent; Process; Production; Proteins; public health relevance; recruit; repaired; Risk; Risk Factors; Rupture; Ruptured Aneurysm; Sampling; Serum; Shapes; Signal Transduction; Site; Smoking; Structure; Survival Rate; T cell response; T-Lymphocyte; Testing; therapeutic target; Tissues; Ultrasonography; Uncertainty; United States; Veterans; Work; ","Immune-mediated pathways in pathogenesis of abdominal aortic aneurysm","002714","CARB","Cardiovascular Studies B ","","","06","","","",""
"9914134","K23","MH","5","N","05/22/2020","04/01/2020","03/31/2021","242","K23MH112889","SCHOOLS OF MEDICINE","PA-16-198","5K23MH112889-03","NIMH:194344\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PROVIDENCE","UNITED STATES","PSYCHIATRY","01","001785542","US","1003201","BROWN UNIVERSITY","RI","029129002","PROJECT NARRATIVE Understanding mechanisms underlying the development of BPD features in adolescence is critical to developing effective interventions for this challenging and expensive to treat disorder. The proposed research tests a theory that anger rumination functions as a directly rewarding but maladaptive emotion regulation strategy that confers risk on a neurological level for the development of the reactive, impulsive, and aggressive habits characteristic of BPD. Specifically, the impact of anger rumination on neural reward circuits will be assessed, and this reward activation used to predict connections between internalizing and impulsive networks of BPD symptoms.","11658339; ","PETERS, JESSICA RACHAEL;","BECHTHOLT, ANITA J","04/01/2018","03/31/2023","Adolescence; Adolescent; Affect; aged; Aggressive behavior; Anger; Anterior; Area; Arousal; base; Behavior; Behavioral; Behavioral Mechanisms; behavioral pharmacology; behavioral response; Biological; Borderline Personality Disorder; career development; Characteristics; Clinical; Clinical Research; cognitive process; Conscious; cost; Data; Data Analyses; depressive symptoms; design; Development; Disease; Disinhibition; Distress; Early Intervention; Eating Disorders; effective intervention; emotion regulation; Emotional; Emotions; empowerment; Ethical Issues; experience; externalizing behavior; Feeling; Female Adolescents; follow-up; Food; Functional Magnetic Resonance Imaging; Funding; Goals; Habits; Health system; Hostility; Image Analysis; imaging study; Impairment; Impulsive Behavior; Impulsivity; Individual; Institution; Insula of Reil; Intervention; K-Series Research Career Programs; Knowledge; learning network; Link; Mental Health; Mentorship; Methodology; Modeling; Monitor; Motivation; negative affect; Negative Reinforcements; network models; neural circuit; neural correlate; Neurobiology; Neurologic; neuromechanism; Nucleus Accumbens; Outcome; Pain management; Participant; Pathway Analysis; Pattern; pleasure; Population; Positive Reinforcements; Preventive Intervention; Preventive screening; Process; programs; Psychopathology; Public Health; Recording of previous events; recruit; Regulation; relating to nervous system; Research; Research Personnel; Research Training; response; Rewards; Risk; Risk Factors; Role; Sampling; Self-Direction; Self-Injurious Behavior; sex; Shame; skills; Substance Use Disorder; Suicide; Symptoms; System; Testing; theories; Time; To specify; Training; trait; Translational Research; United States National Institutes of Health; Universities; Validation; Veins; vulnerable adolescent; Woman; young adult; ","Anger Rumination in the Development of Psychopathology","112889","CPDD","Child Psychopathology and Developmental Disabilities Study Section ","","","03","179948","14396","194344",""
"9926307","R01","HL","5","N","05/18/2020","05/01/2020","04/30/2021","838","R01HL142720","","PA-18-484","5R01HL142720-02","NHLBI:622064\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","NARRATIVE Pulmonary arterial hypertension is a relentless disease characterized by vascular obliteration, right heart failure and death; approximately 40% of patients are dead within 5 years of diagnosis. This grant aims to use advanced genetic and Omic techniques to select patients most likely to benefit from prostacyclin therapy, the most potent therapy available with a portion of patients having marked improvement. The long term goal is to correctly match a patients unique biology to the appropriate therapy in PAH, thereby improving outcomes in this highly morbid disease.","8157667; ","HEMNES, ANNA R;","XIAO, LEI","05/15/2019","04/30/2023","Achievement; Acute; Address; base; biobank; Biological; Biology; Blood specimen; Blood Vessels; Calcium Channel Blockers; Cessation of life; Clinical; clinical predictors; cohort; Cyclic AMP; Data; Diagnosis; Disease; DNA; drug efficacy; drug response prediction; effective therapy; Endothelium; Enrollment; exome sequencing; experimental study; FDA approved; Future; Genes; Genetic; Genetic Determinism; genetic predictors; genetic profiling; Genetic Transcription; genetic variant; Genetic Variation; genomic signature; Genomics; Genotype; Goals; Grant; Heart failure; hemodynamics; improved; improved outcome; Individual; individual patient; insight; Link; Lung; Measures; Mediating; Mediator of activation protein; Medical Records; metabolomics; Methodology; Molecular; Ontology; Outcome; Pathway interactions; Patient Care; patient response; Patients; Pattern; peripheral blood; Pharmaceutical Preparations; Phenotype; precision medicine; pressure; Prevalence; Production; prospective; prospective test; Prostaglandins I; Proteomics; Publishing; pulmonary arterial hypertension; Pulmonary artery structure; receptor; Receptor Activation; receptor expression; Receptor Gene; Reporting; response; RNA; Sampling; Selection for Treatments; Severity of illness; Signal Transduction; Single Nucleotide Polymorphism; Stem cells; Techniques; Testing; transcriptomics; Variant; Vasodilator Agents; ","Genomic and Circulating Predictors of PAH response","142720","ZRG1","Special Emphasis Panel ","","","02","365920","256144","622064",""
"10138117","R00","HL","4","N","05/16/2020","05/18/2020","04/30/2021","837","R00HL141583","HOSPITALS","PA-16-193","4R00HL141583-03","NHLBI:249000\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","TYLER","UNITED STATES","BIOCHEMISTRY","01","800772337","US","578420","UNIVERSITY OF TEXAS HLTH CTR AT TYLER","TX","757083154","Atherosclerosis is the primary cause of heart attack, stroke, and peripheral arterial disease, which accounts for ~40% of all deaths in the United States. We have identified a gene called dedicator of cytokinesis 2, which plays a key role in endothelial inflammation and macrophage activation/function in atherogenesis. The proposed studies will shed new lights on the pathogenesis of atherosclerosis and may ultimately lead to the identification of novel targets for developing therapeutic agent to treat atherosclerosis.","12168709; ","GUO, XIA ;","HUANG, LI-SHIN","05/15/2020","04/30/2023","Adhesions; Adipose tissue; Arterial Fatty Streak; atherogenesis; Atherosclerosis; Attenuated; cadherin 5; Cause of Death; CCL2 gene; CD36 gene; Cell Adhesion; Cell Adhesion Molecules; Cells; Cessation of life; Chronic; Complex; Coronary Arteriosclerosis; cytokine; Cytokinesis; Data; Development; Diet; Disease; Endothelial Cells; Endothelium; Event; Foam Cells; Functional disorder; Genes; Hematopoietic; Human; in vivo; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Intercellular adhesion molecule 1; Interleukin-6; Knockout Mice; Lead; Lesion; Lipids; Low-Density Lipoproteins; Lymphocyte; macrophage; Macrophage Activation; Mediating; Mediator of activation protein; Metabolic Diseases; migration; Molecular; monocyte; mouse model; Mus; Myocardial Infarction; novel; novel therapeutics; Oxides; oxidized low density lipoprotein; Pathogenesis; Patients; Peripheral arterial disease; Phagocytosis; Pharmaceutical Preparations; Phase; Phenotype; Physiological; Play; Process; Production; promoter; Reporting; Risk Factors; Role; scavenger receptor; Signal Pathway; Stroke; Testing; Therapeutic; Therapeutic Agents; TNF gene; United States; uptake; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Cell; vascular inflammation; Vascular remodeling; ","Dedicator of cytokinesis 2 in atherosclerosis","141583","NSS","Special Emphasis Panel ","","","03","169388","79612","249000",""
"9944258","R01","DK","1","N","05/18/2020","05/20/2020","04/30/2021","847","R01DK124318","SCHOOLS OF MEDICINE","PA-19-056","1R01DK124318-01","NIDDK:564086\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","LA JOLLA","UNITED STATES","INTERNAL MEDICINE/MEDICINE","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","PROJECT NARRATIVE This proposal will collect the necessary evidence to make an informed decision on whether screening the diabetic population for advanced liver fibrosis due to NAFLD is advisable and cost-effective. We will also define the best screening approach, balancing diagnostic accuracy and availability with cost.","9825707; ","LOOMBA, ROHIT ;","DOO, EDWARD","05/20/2020","04/30/2023","Address; Adult; Affect; Age; Area; base; Biological Markers; Biopsy; Cessation of life; Chronic; Cirrhosis; Clinical; clinical practice; cohort; cost; cost effective; cost effectiveness; Cost Effectiveness Analysis; cost-effectiveness evaluation; Costs and Benefits; Data; density; Detection; diabetic; Diagnostic; diagnostic accuracy; diagnostic screening; Diagnostic tests; Disease; Disease Progression; Early identification; elastography; Equilibrium; Exhibits; Fatty acid glycerol esters; Fatty Liver; Fibrosis; Future; Goals; Gold; Hepatic; high risk population; Image; imaging biomarker; imaging modality; Intervention; Knowledge; Liver; liver biopsy; Liver diseases; Liver Fibrosis; liver transplantation; Longitudinal Studies; Magnetic Resonance Imaging; mathematical model; Modeling; Monitor; mortality risk; non-alcoholic fatty liver disease; Non-Insulin-Dependent Diabetes Mellitus; non-invasive imaging; nonalcoholic steatohepatitis; outcome forecast; Participant; Patients; Phenotype; Pilot Projects; Population; Practice Guidelines; Prevalence; Primary carcinoma of the liver cells; primary outcome; Prospective cohort; Protons; Reference Standards; Reproducibility; Risk; Risk Factors; routine screening; screening; Serum; Subgroup; Technology; Testing; Time; Uncertainty; ","Non-invasive screening of diabetics for advanced fibrosis due to NAFLD","124318","HBPP","Hepatobiliary Pathophysiology Study Section ","","","01","361708","202378","564086",""
"9923614","R01","DA","5","N","05/18/2020","05/01/2020","04/30/2021","279","R01DA046534","SCHOOLS OF PUBLIC HEALTH","PAR-16-234","5R01DA046534-03","NIDA:435239\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","BALTIMORE","UNITED STATES","BIOSTATISTICS & OTHER MATH SCI","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Program Director/Principal Investigator (Last, First, Middle): Scharfstein, Daniel, Oscar Project Narrative We will develop, implement and disseminate an innovative sensitivity analysis methodology and open-source, user-friendly software tool to evaluate the robustness to missing data assumptions of clinical trials in which binary outcomes are collected at ?xed points over time but where participants intermittently miss their scheduled assess- ments, as frequently occurs in addiction research. We will utilize this tool to reanalyze data from 29 substance abuse clinical trials conducted by NIDA's Clinical Trials Network and available publicly on NIDA's DataShare web- site. As a result, we will be better able to understand the impact of missing data assumptions on the evaluation of the studied interventions and, by demonstrating the importance and utility of our tool to an advisory board comprised of study investigators and to the substance use disorder community more broadly, we aim to make ?stress-testing? to untestable missing data assumptions a more routine part of scienti?c reporting.","8510435; ","SCHARFSTEIN, DANIEL OSCAR;","WILEY, TISHA R A","08/15/2018","04/30/2021","addiction; Address; Adoption; Alcohol or Other Drugs use; base; Case Study; Clinical; Clinical Trials; Clinical Trials Network; Communities; Computer software; Conduct Clinical Trials; Coupled; Data; Data Analyses; Data Set; data sharing; Development; Ensure; Evaluation Studies; Explosion; flexibility; Future; Goals; Health; Health system; HIV; HIV risk; Individual; innovation; interest; Intervention Studies; journal article; knowledge translation; Lead; Link; Literature; machine learning algorithm; Methodology; Methods; Movement; National Institute of Drug Abuse; novel; Online Systems; open data; open source; Outcome; Outcome Assessment; Outcome Measure; Participant; Pattern; Performance; Persons; Pharmaceutical Preparations; premature; prevent; Principal Investigator; Procedures; programs; Property; Publishing; Randomized; Randomized Clinical Trials; Reporting; Reproducibility; Research; Research Design; Research Personnel; Risk Behaviors; Schedule; Scientist; secondary analysis; simulation; software development; Software Tools; Source; Stress Tests; study characteristics; Substance abuse problem; Substance Use Disorder; Testing; Time; tool; treatment effect; Uncertainty; Urine; user friendly software; user-friendly; web site; webinar; Withdrawal; Work; ","Missing Data Matters: Substance Use Disorder Clinical Trials","046534","ZRG1","Special Emphasis Panel ","","","03","282454","152785","435239",""
"9916743","U10","CA","5","N","05/18/2020","03/01/2020","02/28/2021","","U10CA180868","","RFA-CA-17-056","5U10CA180868-07","NCI:4012794\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","PHILADELPHIA","UNITED STATES","","03","078695317","US","10033231","NRG ONCOLOGY FOUNDATION, INC.","PA","191032800","","1873940; ","WOLMARK, NORMAN ;","","","","Advocate; Amendment; Attention; Cancer Therapy Evaluation Program; Clinical Oncology; Clinical Trials; Clinical Trials Data Monitoring Committees; Committee Members; Complex; data management; design; Development; Disease; experience; Goals; Infrastructure; International; investigator training; Knowledge; Leadership; member; Mentorship; Mission; Multi-Institutional Clinical Trial; oncology; Oncology Group; operation; Patients; Phase; Physicians; Program Development; programs; prospective; protocol development; Publications; Regulatory Affairs; Research; Research Activity; Research Personnel; Safety; Site; statistics; success; Support Groups; Time; Translational trial; Work; ","NRG Oncology Network Group Operations Center","180868","ZCA1","Special Emphasis Panel ","7984","","07","4477354","134284","","4012794"
"10131357","U01","DK","3","N","05/21/2020","02/01/2020","01/31/2021","847","U01DK057002","SCHOOLS OF EDUCATION","RFA-DK-15-501","3U01DK057002-21S1","NIDDK:71334\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","PITTSBURGH","UNITED STATES","MISCELLANEOUS","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","PUBLIC HEALTH RELEVANCE: Weight loss is recommended for overweight and obese individuals with type 2 diabetes, but the long-term effects of such approaches on the issues of greatest concern to older individuals --including mortality, health care utilization and costs, diabetic complications, quality of life, and frailty -- remain untested. The Look AHEAD-Extension will follow approximately 3800 of these individuals for an additional 4.5 years to determine whether random assignment to an intensive lifestyle intervention focused on weight loss achieved through healthy eating and increased physical activity relative to a control group leads to improved long-term health in later life. This extended follow-up will provide important information about the long-term beneficial effects of a lifestyle intervention in a growing segment of the population-namely those who are older, overweight or obese, and have type 2 diabetes.","1893525; ","JAKICIC, JOHN M;","KUCZMARSKI, ROBERT J","09/30/1999","01/31/2021","Address; adult obesity; Age; Age-Years; Aging; Ancillary Study; Biochemical; Body Weight decreased; Bone Density; Cardiovascular Diseases; Caring; Clinic Visits; Clinical; Clinical Trials; cohort; comorbidity; Complications of Diabetes Mellitus; Control Groups; cost; cost effective; Data; Data Analyses; Diabetes Mellitus; diabetic; Dimensions; Disease; Education; Elderly; Event; Face; Fatty acid glycerol esters; follow-up; frailty; functional disability; Genetic; Goals; group intervention; Guidelines; Health; Health Care Costs; health care service utilization; Healthcare; healthy aging; Healthy Eating; improved; Incidence; Independent Living; Individual; Infrastructure; Intervention; Kidney Diseases; Lead; Life; lifestyle intervention; Long-Term Effects; Longevity; Measures; medical complication; Microvascular Dysfunction; middle age; mortality; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; outcome prediction; Overweight; Participant; Pathway interactions; Patient-Focused Outcomes; Persons; Phase; Physical activity; Physical Function; Population; post intervention; primary outcome; Process; programs; Public Health; public health relevance; Publications; Quality of life; Randomized; Randomized Controlled Clinical Trials; randomized trial; Recording of previous events; Reporting; Research Project Grants; research study; resilience; secondary outcome; Subgroup; Telephone; Testing; Thinness; trial comparing; Uncontrolled Study; Weight; Weight Gain; ","11/16 Action for Health in Diabetes Extension Study Research Project","057002","ZDK1","Special Emphasis Panel ","","S1","21","45581","25753","71334",""
"9944030","R01","ES","1","N","05/18/2020","05/19/2020","03/31/2021","113","R01ES031596","SCHOOLS OF ARTS AND SCIENCES","PA-19-056","1R01ES031596-01","NIEHS:316879\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","RALEIGH","UNITED STATES","BIOLOGY","04","042092122","US","578204","NORTH CAROLINA STATE UNIVERSITY RALEIGH","NC","276950001","PROJECT NARRATIVE Cadmium is a toxic metal that is a major public health concern, due to its ubiquity in the human environment. If successful, our work will show that exposure to cadmium during development causes non-alcoholic fatty liver disease in later life through activating a specific set of genes, identifying these genes as potential markers of disease susceptibility and novel targets for treatment. Given that NAFLD affects 30-40 % of the US adult population, and has been linked to metabolic impairments and a shorter lifespan, findings from our work have the potential to improve disease prediction and management for a large number of people.","12583359; ","COWLEY, MICHAEL ;","TYSON, FREDERICK L","05/19/2020","03/31/2025","Adult; Affect; Alleles; base; Behavior Disorders; Cadmium; Cardiovascular Diseases; Cell Culture Techniques; Cell model; Chemicals; Child; Data; Deposition; Development; developmental disease; Disease; Disease Marker; Disease susceptibility; disorder prevention; DNA; DNA Methylation; Dose; Elderly; Environment; Epigenetic Process; Event; Exposure to; Extracellular Matrix; Fatty acid glycerol esters; Functional disorder; Gene Activation; Genes; Genetic; Genetic Transcription; genome-wide; Health; Heavy Metals; Hepatic Stellate Cell; Hepatocyte; high risk; Human; human data; human model; Impairment; imprint; improved; in vivo; Inflammation; K-Series Research Career Programs; Kidney; Knowledge; Lead; Life; Link; Lipids; Liver; liver metabolism; Longevity; Malignant neoplasm of liver; Metabolic; Metabolic Diseases; Metabolic syndrome; Modeling; Molecular; Molecular Profiling; Molecular Target; mouse model; Mus; National Institute of Environmental Health Sciences; Nature; new therapeutic target; Newborn Infant; non-alcoholic fatty liver disease; North Carolina; novel; Onset of illness; Paracrine Communication; Pathway interactions; Patients; Play; Population; Pregnant Women; prevent; Production; Program Development; programs; Public Health; Relaxation; Respiratory System; Role; Skeletal system; stressor; System; Testing; Therapeutic Intervention; Tissues; Toxic effect; toxic metal; toxicant; Umbilical Cord Blood; Up-Regulation; Work; World Health Organization; ","The Imprinted Gene Network in the programming of Non-Alcoholic Fatty Liver Disease by early life cadmium exposure","031596","SIEE","Systemic Injury by Environmental Exposure ","","","01","214969","101910","316879",""
"10159745","I01","VA","5","N","05/17/2020","07/01/2018","06/30/2019","999","I01HX001589","","RFA-HX-14-014","5I01HX001589-04","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","INDIANAPOLIS","UNITED STATES","","07","608434697","US","481029","RLR VA MEDICAL CENTER","IN","462022803","Chronic pain affects approximately 100 million Americans and 40-70% of Veterans. Pain is costly, disabling, and exerts an appreciable negative impact on these Veterans' lives. Pain self-management is an important component of chronic pain treatment, and is at the foundation of VHA's 2009 Pain Directive. However, providing pain self- management instruction to Veterans is time-consuming and resource intensive, especially when Veterans require motivational and emotional support. ECLIPSE is a randomized controlled trial that tests a novel approach to pain self-management: a peer coaching model, in which Veterans with chronic pain offer information, support, and mentorship to other Veterans.","10043921; ","MATTHIAS, MARIANNE ;","","07/01/2015","09/30/2019","Address; Advocate; Affect; American; arm; base; Behavior; Behavioral; Brief Pain Inventory; Budgets; Caring; Chronic; chronic musculoskeletal pain; chronic pain; Clinic; Clinical; Complement; Consumption; coping; Coping Skills; cost; Data; Data Collection; design; disability; dosage; Education; Effectiveness; Emotional; emotional distress; Enrollment; Environment; Evaluation; Evidence based treatment; experience; Family; Feedback; Financial compensation; financial incentive; Foundations; Funding; Gases; Goals; health care service utilization; health related quality of life; health service use; Healthcare; Hour; human subject protection; Human Subject Research; Hybrids; impression; improved; Incentives; innovation; Institute of Medicine (U.S.); Instruction; Intervention; intervention cost; Interview; Leadership; Life; Literature; Manuals; Measures; Medical Care Costs; Medical Care Team; meetings; Mentorship; Methods; Minority; Modeling; morphine equivalent; Motivation; non-cancer chronic pain; Non-Malignant; non-opioid analgesic; novel; novel strategies; Nurses; Opioid; Opioid Analgesics; Outcome; Outcome Study; Pain; Pain intensity; Pain interference; Pain management; pain reduction; pain self-management; pain symptom; Participant; Patients; payment; peer; peer coaching; peer support; Persons; Pharmaceutical Preparations; Pharmacological Treatment; prescription opioid; primary endpoint; Primary Health Care; primary outcome; Productivity; Professional counselor; programs; Protocols documentation; Quality of life; Race; Randomized; Randomized Controlled Trials; recruit; Research; Research Design; Research Personnel; Research Priority; Resources; response; Risk; screening; secondary outcome; Self Efficacy; Self Management; self-management program; social; Social support; Solid; Suicide; Supervision; Telephone; Testing; Time; TimeLine; Training; treatment adherence; trial design; Veterans; Visit; willingness; Woman; Work; ","Evaluation of peer Coach-Led Intervention to improve Pain Symptoms (ECLIPSE)","001589","HSR2","HSR-2 Determinants of Patient Response to Care   ","","","04","","","",""
"10043368","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI154179","SCHOOLS OF ARTS AND SCIENCES","PA-19-053","1R21AI154179-01","NIAID:194550\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","TAMPA","UNITED STATES","CHEMISTRY","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","Project Narrative New treatments for protozoal infections such as malaria, leishmaniasis and human African trypanosomiasis are urgently needed. Many anti-protozoal drugs originate from natural products. This project seeks to uncover new natural product-inspired drugs with bioactivity against these infections using contemporary and innovative approaches in sourcing and screening.","1964603; ","BAKER, BILL J;","O'NEIL, MICHAEL T","05/22/2020","04/30/2022","Acquired Immunodeficiency Syndrome; Address; Affect; African; African Trypanosomiasis; antimicrobial; Antiprotozoal Agents; Artemisinins; base; Biocontrols; Biodiversity; Biological; Biological Assay; Characteristics; Chemicals; Chronic; Clinical; Collection; Communicable Diseases; Communities; cytotoxicity; Development; disability; disability-adjusted life years; Disease; Dose; drug development; drug discovery; Drug Prescriptions; Dwarfism; Economics; endophytic fungi; Epigenetic Process; epigenetic regulation; Face; Florida; Fractionation; fungus; Future; Genes; Genomics; Guidelines; Health system; Human; Infection; innovation; Lead; Leishmania donovani; Leishmaniasis; Lower Respiratory Tract Infection; Malaria; Measures; Medicinal Plants; Modernization; Morbidity - disease rate; Multi-Drug Resistance; Natural Product Drug; Natural Products; Nature; novel; novel therapeutics; Parasites; pathogen; Pathway interactions; Pharmaceutical Preparations; Pharmacy facility; Phenotype; Planet Earth; Plasmodium falciparum; Poverty; Production; programs; Protozoan Infections; Quinine; response; Safety; screening; screening program; side effect; Source; Stretching; Structure; Techniques; Therapeutic; therapeutic target; Time; Translations; Trypanosoma brucei gambiense; Tuberculosis; Universities; Work; World Health Organization; ","Induction of antiprotozoal secondary metabolites from endophytic fungi using epigenetic modifiers","154179","ZRG1","Special Emphasis Panel ","","","01","150000","44550","194550",""
"9924655","P20","NR","5","N","05/22/2020","05/01/2020","04/30/2021","","P20NR016599","","RFA-NR-16-001","5P20NR016599-05","NINR:215703\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","HADLEY","UNITED STATES","","02","153926712","US","850904","UNIVERSITY OF MASSACHUSETTS AMHERST","MA","010359450","","1882615; ","WYSOCKI, ANNETTE B;","","","","Activities of Daily Living; Acute; Address; Adult; Affect; Arthritis; base; Beds; Behavior; Biological Markers; Cellular Phone; Chronic; Chronic Disease; Common Data Element; Computer Analysis; Computers; Congestive Heart Failure; cost; Detection; Development; Devices; Drug Prescriptions; Engineering; Exercise; experience; Eyeglasses; Family; Fatigue; Feedback; Fibromyalgia; functional status; Goals; handheld equipment; Health; health care service; Healthcare; Home Care Services; Human; human subject; Hydrocortisone; improved; Individual; innovation; innovative technologies; Intervention; Intervention Studies; Lead; Length of Stay; Malignant Neoplasms; Massachusetts; Mentors; mindfulness; Monitor; multiple chronic conditions; Multiple Sclerosis; Nurses; Obstructive Sleep Apnea; Office Visits; Onset of illness; Peer Review; persistent symptom; Physiological; Pilot Projects; Postpoliomyelitis Syndrome; prevent; Productivity; psychologic; Quality of life; Regulation; Reporting; Research Proposals; Saccades; Science; Scientist; Self Management; sensor technology; Sleep disturbances; Stress; Stroke; symptom management; symptom science; symptom self management; symptomatic improvement; Symptoms; Tablets; Technology; Testing; Time; United States National Institutes of Health; Universities; Vertebrates; Walkers; wearable sensor technology; Wireless Technology; Workplace; ","UManage Projects Core","016599","ZNR1","Special Emphasis Panel ","5302","","05","175416","102601","","215703"
"9927958","T32","AG","5","N","05/18/2020","05/01/2020","04/30/2021","866","T32AG000243","SCHOOLS OF ARTS AND SCIENCES","PA-14-015","5T32AG000243-25","NIA:312975\","TRAINING, INSTITUTIONAL","2020","NATIONAL INSTITUTE ON AGING","","CHICAGO","UNITED STATES","SOCIAL SCIENCES","01","005421136","US","1413601","UNIVERSITY OF CHICAGO","IL","606375418","PUBLIC HEALTH RELEVANCE: This program trains exceptional students as researchers in the demography and economics of aging. These trainees will, over their research careers, produce research findings directly relevant to public policy and public health, on such topics as mental health, access to medical services, and health disparities.","1861051; ","WAITE, LINDA J;","PATMIOS, GEORGEANNE E","09/30/1994","04/30/2021","Aging; Demography; Economics; Training; ","Specialized Training: Demography and Economics of Aging - Renewal 01","000243","ZAG1","Special Emphasis Panel ","","","25","305768","20316","312975",""
"9906908","R01","GM","5","N","05/21/2020","05/01/2020","04/30/2021","859","R01GM124203","SCHOOLS OF ARTS AND SCIENCES","PA-16-160","5R01GM124203-04","NIGMS:306832\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","ATHENS","UNITED STATES","BIOCHEMISTRY","10","004315578","US","676602","UNIVERSITY OF GEORGIA","GA","306021589","PROJECT NARRATIVE The proposed studies will illuminate a set of enzymes involved in the process of anaerobic heme degradation in aggressive pathogens. Until our discovery the mechanism of anaerobic heme degradation was unknown. Furthermore, the penultimate enzyme in this newly discovered pathway (ChuW) is a member of a powerful class of understudied enzymes with demonstrated utility in production of antimicrobials and antitumor compounds.","2444147; ","LANZILOTTA, WILLIAM N;","ANDERSON, VERNON","07/15/2017","04/30/2021","5'-deoxyadenosine; Address; Aerobic; Anabolism; Anaerobic Bacteria; Animal Model; antimicrobial; antineoplastic antibiotics; antitumor agent; Area; base; Biliverdin reductase; Binding; Biochemical; Biological Assay; Biophysics; Carbon; Catalysis; Cells; Cessation of life; Chemicals; Coupled; Crystallization; cyclopropane; Data; Degradation Pathway; Diet; Disease; Distal; drug development; enteric pathogen; Environment; Enzyme Kinetics; Enzymes; Escherichia coli; Escherichia coli EHEC; Escherichia coli O157:H7; experimental study; Future; Genes; Goals; Health; Heart; Heme; Heme Iron; Hemolytic-Uremic Syndrome; Hemorrhagic colitis; Homeostasis; Human; Hybrids; in vitro Assay; Infection; insight; Intestines; Investigation; Iron; Iron Chelation; Kidney Failure; Kinetics; member; Metal Ion Binding; Methyltransferase; Modernization; Modification; Molecular; NADP; novel; Organism; Outcome; Oxides; Oxygen; pathogen; pathogenic bacteria; Pathogenicity; Pathway interactions; Play; Porphyrins; Process; Production; Property; protein complex; Proteins; Protocols documentation; protoporphyrin IX; public health relevance; Reaction; Regulation; Role; S-Adenosylhomocysteine; Source; structural biology; Structure; Techniques; Tetrapyrroles; tool; tumor; Vibrio cholerae; Virulence; Work; ","A radical new paradigm for heme degradation in enteric pathogens","124203","MSFA","Macromolecular Structure and Function A Study Section ","","","04","225758","81074","306832",""
"9921222","U54","MD","5","N","05/18/2020","04/01/2020","03/31/2021","","U54MD010722","","RFA-MD-15-013","5U54MD010722-05","NIMHD:301623\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","7854859; ","KRIPALANI, SUNIL ;","","","","Address; Adoption; Area; Bioethics; Caring; Characteristics; Clinical Data; Communication; Communities; Decision Making; Diagnostic; Diffusion; Education; Ensure; Ethical Issues; Ethics; ethnic minority population; evidence base; Evidence based intervention; experience; Familiarity; Focus Groups; Fostering; Funding Mechanisms; General Population; Genetic; Genetic Medicine; Genetic screening method; genomic data; Genomics; Goals; Health; health disparity; health equity; health literacy; Health Personnel; Health Policy; Health Professional; Health Services Accessibility; implementation science; improved; Individual; Intervention; Knowledge; Language; Limited English Proficiency; Linguistics; literacy; Minority; Minority Groups; new technology; organizational structure; Patients; Perception; Policy Maker; Population; population health; precision medicine; Precision Medicine Initiative; Privacy; Process; programs; racial minority; Research; Research Project Grants; Resources; Series; social; Speed; Surveys; Therapeutic; Time; Training; Translating; Translations; Trust; Work; ","Implementation Core","010722","ZMD1","Special Emphasis Panel ","8201","","05","233858","67765","","301623"
"9916740","U10","CA","5","N","05/18/2020","03/01/2020","02/28/2021","395","U10CA180868","","RFA-CA-17-056","5U10CA180868-07","NCI:14059246\","OTHER RESEARCH-RELATED","2020","NATIONAL CANCER INSTITUTE","","PHILADELPHIA","UNITED STATES","","03","078695317","US","10033231","NRG ONCOLOGY FOUNDATION, INC.","PA","191032800","NRG Oncology seeks to improve the lives of adult patients with gender-specific malignancies (breast, gynecologic, prostate cancers) and/or localized or locally advanced cancer through the development and conduct of a portfolio of timely and relevant clinical trials. NRG uniquely focuses on this large and relatively under-investigated group of cancer patients and has extraordinary scientific accomplishments specific to the group's three specific aims. NRG actively assists in the management of the NCI - National Clinical Trial Network (NCTN) and collaborates with the other NCTN partners in the overall conduct of all NCTN trials.","9294195; 2488117; 1873940 (contact); ","CURRAN, WALTER J.; MANNEL, ROBERT S; WOLMARK, NORMAN  (contact);","MOONEY, MARGARET M","04/17/2014","02/28/2025","Adult; advanced disease; advanced prostate cancer; African; Area; Awareness; Brain Neoplasms; Breast; Cancer Patient; Cancer Therapy Evaluation Program; Clinical Research; Clinical Trials; clinically relevant; cohort; design; Development; Disease; Enrollment; Ensure; Gender; Goals; Gynecologic; Head and Neck Cancer; Hispanics; improved; interest; International; Latino; Lead; Leadership; Locally Advanced Malignant Neoplasm; malignant breast neoplasm; Malignant Female Reproductive System Neoplasm; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of lung; Malignant neoplasm of prostate; Malignant neoplasm of urinary bladder; Malignant Neoplasms; Manuscripts; member; multidisciplinary; National Clinical Trials Network; Non-Hematologic Malignancy; oncology; oncology trial; operation; patient population; Patients; Peer Review; Positioning Attribute; Precision medicine trial; Protocols documentation; Publishing; Research; sarcoma; Scientific Advances and Accomplishments; Site; Time; Translational Research; ","NRG Oncology Network Group Operations Center","180868","ZCA1","Special Emphasis Panel ","","","07","15452927","402852","14059246",""
"10155104","I01","VA","5","N","05/21/2020","05/01/2020","04/30/2021","999","I01RX001986","","RFA-RX-15-003","5I01RX001986-05","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","MOUNTAIN HOME","UNITED STATES","","01","098074776","US","481114","JAMES H QUILLEN VA MEDICAL CENTER","TN","376844000","PUBLIC HEALTH RELEVANCE     Relevance of the Proposed Work to the VA Patient Care Mission. Noise-related auditory dysfunction is the most common service-connected condition in Veterans. Although the impact of noise on hearing is well known, less is understood about the effects of noise on vestibular and balance function. Interest in this area has been driven by observations in the military suggesting that battlefield-related noise can cause balance disorders characterized by vertigo, dizziness, and postural instability. Symptoms of dizziness and imbalance can impact safety and reduce quality of life for Veterans. Our proposed studies will test for the underlying cause and mechanisms of noise-induced vestibular dysfunction in parallel human and animal studies. The results will improve the ability to identify and diagnose these problems with the long term goal of  developing novel therapeutics to prevent and treat noise related vestibular dysfunction.","9383784 (contact); 1921919; ","AKIN, FAITH WURM (contact); HOLT, AVRIL GENENE ;","","05/01/2016","04/30/2021","3-nitrotyrosine; 4 hydroxynonenal; Address; Animal Model; Animals; Antibodies; Area; arm; Auditory; cell injury; Cells; Cervical; Clinical; Clinical Protocols; Cochlea; Control Groups; Development; Diagnosis; Dizziness; Epithelial; Epithelium; equilibration disorder; Equilibrium; Evaluation; Exposure to; Fire - disasters; Free Radical Formation; Frequencies; Functional disorder; Goals; Head; Hearing; hearing impairment; Human; human model; imaging modality; improved; Individual; interest; Investigation; Knowledge; Magnetic Resonance Imaging; Manganese; Maps; Military Personnel; Mission; Modeling; Molecular; Morphology; Neuraxis; Neurons; Noise; Noise-Induced Hearing Loss; novel; novel therapeutics; Organ; otoconia; Outer Hair Cells; Pathway interactions; Patient Care; Peripheral; posture instability; prevent; public health relevance; Quality of life; Rattus; rehabilitation strategy; Saccule and Utricle; Safety; secondary analysis; Semicircular canal structure; Sensory; Sensory Receptors; Services; Symptoms; System; Test Result; Testing; Therapeutic; Utricle structure; Vertigo; Vestibular Function Tests; Vestibular Hair Cells; Vestibular loss; Vestibular Nerve; vestibular pathway; Veterans; Work; ","The Effect of Noise Exposure on the Vestibular System","001986","RRD3","Sensory Systems & Communication Disorders ","","","05","","","",""
"10058365","R56","MH","1","N","05/20/2020","05/20/2020","04/30/2021","242","R56MH121555","","RFA-MH-18-707","1R56MH121555-01","NIMH:336791\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","EAST ORANGE","UNITED STATES","","10","114580926","US","3954501","VETERANS BIOMEDICAL RESEARCH INSTITUTE","NJ","070181023","Narrative Patients with chronic pain in the US (100 million) have 2.6-times greater risk of suicide and those on long-term opioid treatment are at even greater risk. Unfortunately, they often do not receive suicide prevention interventions; they do receive frequent healthcare for their pain providing an unmet opportunity to integrate suicide prevention into their treatment for pain. This study aims to test the efficacy of remote-delivered Problem-Solving Treatment for patients with chronic pain and moderate suicide risk.","10205569; ","MCANDREW, LISA MARIE;","O'CONNOR, STEPHEN","05/20/2020","04/30/2022","Address; Aftercare; Behavior Therapy; chronic pain; chronic pain patient; Clinical; Clinical Trials; comorbidity; disability; Educational process of instructing; efficacy testing; evidence base; executive function; Feeling; Feeling suicidal; Goals; Health education; Health Services Accessibility; Healthcare; Healthcare Systems; high risk; Impairment; Improve Access; Individual; Mediating; Medical; Medical center; Mental Health; Opioid; Pain; Pain management; Pathway interactions; Patients; Persons; Population; prescription opioid; Prevention program; Preventive Intervention; Primary Health Care; Problem Solving; Protocols documentation; reducing suicide; Research; Risk; Services; social relationships; suicidal behavior; suicidal morbidity; suicidal risk; Suicide; Suicide prevention; Time; United States National Institutes of Health; ","Suicide Prevention for Patients with Chronic Pain","121555","ZMH1","Special Emphasis Panel ","","","01","260427","76364","336791",""
"9908160","R01","MH","5","N","05/18/2020","04/01/2020","03/31/2021","242","R01MH110939","SCHOOLS OF MEDICINE","PA-16-160","5R01MH110939-04","NIMH:550593\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PHILADELPHIA","UNITED STATES","NEUROLOGY","03","042250712","US","6463801","UNIVERSITY OF PENNSYLVANIA","PA","191046205","Depression is a highly prevalent disorder, and while effective treatments exist they are often difficult to access and expensive. An effective program of computer-augmented cognitive behavioral therapy (CCBT) has been developed to make CBT more widely available. In the current proposal the investigators will use functional and structural magnetic resonance imaging (MRI) to determine novel neural circuit biomarkers of depression treatment response to CCBT.","1860617; ","SHELINE, YVETTE I;","ZALCMAN, STEVEN J","06/05/2017","03/31/2022","active method; Adult; Algorithms; Ambulatory Care Facilities; American; Amygdaloid structure; Anterior; Antidepressive Agents; base; Biological Markers; Brain; Caring; cingulate cortex; Clinical; clinical decision support; Clinical Management; Clinical Trials; Cognitive; Cognitive Therapy; Computer Models; computer program; computerized; Computers; Conflict (Psychology); Consumption; Control Groups; Coping Behavior; cost; cost effective; Data; Depressed mood; Diagnosis; Disease; Dorsal; effective therapy; efficacy testing; Emotional; evidence base; executive function; FDA approved; functional MRI scan; Future; Hour; Image; improved; Individual; Inferior frontal gyrus; Lateral; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Mental Depression; National Institute of Mental Health; negative affect; neural circuit; novel; novel marker; Outcome; Outpatients; Participant; Patients; Pennsylvania; Placebos; Population; Prefrontal Cortex; programs; Protocols documentation; Psychological Tests; Randomized; Recovery; recruit; reduce symptoms; rehearsal; Research Personnel; response; Rest; Risk; Site-Directed Mutagenesis; skills training; Structure; Thick; Thinking; Time; Training; treatment effect; Treatment Efficacy; Treatment outcome; treatment response; Universities; University Hospitals; Variant; Waiting Lists; Work; ","Novel neural circuit biomarkers of depression response to computer-augmented CBT","110939","NPAS","Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section ","","","04","341983","208610","550593",""
"9919616","R01","HD","5","N","05/20/2020","05/01/2020","04/30/2021","865","R01HD076592","SCHOOLS OF ARTS AND SCIENCES","PA-18-484","5R01HD076592-07","NICHD:572108\OD:100000\","Non-SBIR/STTR RPGs","2020","EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT","","PRINCETON","UNITED STATES","BIOCHEMISTRY","12","002484665","US","6661401","PRINCETON UNIVERSITY","NJ","085430036","Narrative Since 2000, the Fragile Families and Child Wellbeing Study (FFCWS) has provided data on a longitudinal birth cohort of nearly 5000 American children (47% Black, 27% Hispanic). To better understand the relationship between social and physical environment, genetics, and child outcome, we will measure mother genotype and create summary scores and other analyses of mothers? genotype and previously measured children?s genotype, DNA methylation, and telomere length, relating this data to measures of child health and wellbeing. Since there is concern that measurement of telomere length (an important measure of stress and wellbeing) is often inaccurate, we will provide experimental data on best practices for telomere length measurement.","1972287; ","NOTTERMAN, DANIEL A.;","BURES, REGINA M","08/01/2013","04/30/2024","15 year old; African; Age; Alleles; American; Americas; Assessment tool; Attention; Award; base; Behavior; behavior influence; Behavioral Genetics; behavioral outcome; Biological; Biological Assay; Biological Markers; Biosocial; Birth; Blood; Characteristics; Child; Child Development; Child Health; Child Welfare; Cities; Cognition; cognitive ability; cohort; Collection; Communities; Computational Biology; Consensus; Copy Number Polymorphism; Data; Data Set; DNA; DNA Methylation; economic outcome; Epigenetic Process; epigenome-wide association studies; Ethnic group; ethnic minority population; experimental study; externalizing behavior; Family; Funding; Gene Expression; Genes; Genetic; genome-wide; Genotype; Health; Health behavior; health of the mother; Hispanics; Immigrant; Individual; Leadership; Length; Letters; Longitudinal Studies; Maternal Behavior; Maternal Health; Measurement; Measures; Mediation; Mediator of activation protein; meetings; Mental Depression; Methylation; Mothers; Neonatal; Outcome; Parents; Pathway interactions; Personal Satisfaction; Phenotype; Physical environment; Policy Maker; Population; population based; Poverty; Price; Problem behavior; Quantitative Trait Loci; racial minority; Research; Research Design; Resources; Risk; Saliva; sample collection; Sampling; Science; Scientist; Services; social; Social Environment; social science research; Social Sciences; Source; Spottings; Standardization; statistics; Stress; symposium; telomere; Testing; tool; Variant; Vulnerable Populations; Work; ","Biological and social mediators of child wellbeing among ethnic groups in Fragile Families","076592","SSPA","Social Sciences and Population Studies A Study Section ","","","07","460732","211376","672108",""
"9994037","R13","HG","1","N","05/22/2020","05/22/2020","04/30/2021","172","R13HG011191","","PA-18-648","1R13HG011191-01","NHGRI:5000\","OTHER RESEARCH-RELATED","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","BETHESDA","UNITED STATES","","08","074816851","US","2604901","FEDERATION OF AMER SOC FOR EXPER BIOLOGY","MD","208143998","Project Narrative Research on chromosome replication, segregation, repair and cell cycle regulation in yeast continues to inform our basic understanding of how cells, including human cells, accurately transmit genetic and epigenetic information during cell division. This success stems in large part from the power of yeast as a platform for development of new genomics, bioinformatics, and big data tools. The goals of the 2020 Federation of American Societies for Experimental Biology (FASEB) Science Research Conference on Yeast Chromosome Biology and Cell Cycle conference are (1) to accelerate the pace of discovery in these fields by rapidly dispersing the latest unpublished work including cutting-edge technical advances in genomics, and (2) to provide visibility and training opportunities for early career investigators and trainees, especially those under- represented in science.","7188041; ","RAGHURAMAN, MOSUR K;","SEN, SHURJO KUMAR","05/22/2020","04/30/2021","Address; American; Attention; Automobile Driving; Big Data Methods; Bioinformatics; Biological Models; Biology; Candida albicans; career; career development; Cell Cycle; Cell Cycle Regulation; Cell division; Cells; chromosome replication; Chromosome Structures; Chromosomes; clinically relevant; Collaborations; Communities; Development; Disabled Persons; DNA biosynthesis; Educational workshop; empowered; Epigenetic Process; Equilibrium; Ethnic Origin; Eukaryota; Eukaryotic Cell; Fellowship; Female; Fission Yeast; Fostering; Gender; Genetic; Genome; genome-wide; genomic tools; Genomics; Genotoxic Stress; Goals; graduate student; Health; high throughput technology; Histones; Human; improved; insight; Institutes; Interdisciplinary Communication; interest; International; male; Maps; meetings; Meiotic Recombination; member; Mission; Modeling; Molecular; National Human Genome Research Institute; new technology; next generation; Nuclear; Organism; Policies; Postdoctoral Fellow; posters; Proteomics; Publications; Recording of previous events; repaired; Research; Research Personnel; Resources; Saccharomyces cerevisiae; Saccharomycetales; Schedule; Science; Scientist; segregation; Senior Scientist; Societies; stem; Students; success; symposium; System; Technology; technology development; Time; tool; tool development; Training; training opportunity; Underrepresented Groups; unpublished works; Woman; Work; Yeast Model System; Yeasts; ","FASEB's 'The Yeast Chromosome Biology and Cell Cycle Conference'","011191","GNOM","National Human Genome Research Institute Initial Review Group ","","","01","5000","0","5000",""
"9931160","R01","CA","5","N","05/22/2020","05/01/2020","04/30/2021","396","R01CA190449","","PA-13-302","5R01CA190449-06","NCI:239637\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","TORONTO","CANADA","","","208469486","CA","3836301","UNIVERSITY HEALTH NETWORK","ON","M5G 2C4","Project Narrative Natural suppression of immune responses against cancer-cell proteins is a significant barrier to targeted immuno-therapy. Recently we found tumors induce expansion of a population of immune suppressive cells in the spleen in contact with a population of scavenging cells, which we had previously reported are critical for inducing immune suppression to cell debris. In our preliminary research we have found that these scavenging cells (macrophages) are required for tumor-driven expansion of the immune suppressive cells (MDSCs). Surprisingly, we also found a stress response generally associated with protein starvation is activated in MDSCs and is required for their development and suppressive characteristics. Herein we predict the two observations are related and cancer-mediated immune suppression requires the action of macrophages and activation of the protein starvation response in MDSCs leading ultimately to suppression of anti-tumor inflammatory immunity. In this proposal we will seek to define the role for macrophages and starvation stress signals in cancer-induced immune suppression and test the theory that blocking this pathway will provide therapeutic benefit in animal models of lymphoma and melanoma.","9046424; ","MCGAHA, TRACY L;","KUO, LILLIAN S","12/01/2015","04/30/2021","Amino Acids; Animal Model; Antigens; arginase; Arginine; arm; autocrine; Autoimmunity; Automobile Driving; base; biological adaptation to stress; Blood Circulation; CCAAT-Enhancer-Binding Proteins; CCL2 gene; CD8-Positive T-Lymphocytes; CD8B1 gene; Cell Differentiation process; Cells; Characteristics; Chemotaxis; chemotherapy; Consumption; cytokine; Cytotoxic T-Lymphocytes; Data; Data Reporting; Dendritic Cells; Development; exosome; factor C; Immune; Immune response; Immunity; Immunologic Tests; Immunosuppression; Immunosuppressive Agents; Immunotherapy; in vivo; Inflammation; Inflammatory; insight; Interleukin-6; Interruption; Lymphocyte Activation; Lymphoma; macrophage; Macrophage Activation; Malignant Neoplasms; Mediating; melanoma; Metabolism; Molecular; Molecular Profiling; Mus; Myelogenous; Myeloid-derived suppressor cells; nanoparticle; new therapeutic target; Pathway interactions; Phenotype; Play; Population; prevent; Process; protein activation; Proteins; Publishing; recruit; Reporting; Research; response; Role; sensor; Signal Transduction; Small Interfering RNA; Spleen; Starvation; Stress; stress kinase; T cell response; Testing; theories; Therapeutic; Time; transcription factor; tumor; Tumor Antigens; Vaccine Antigen; Work; ","The role of marginal zone macrophages and immuno-metabolism in tumor-driven MDSC development","190449","CMIB","Cellular and Molecular Immunology - B Study Section ","","","06","221887","17750","239637",""
"9918112","P30","ES","1","N","05/21/2020","05/15/2020","03/31/2021","","P30ES030284","","RFA-ES-18-003","1P30ES030284-01A1","NIEHS:176962\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","9485654; ","WOODRUFF, TRACEY J.;","","05/22/2020","03/31/2025","Address; Administrator; Advisory Committees; Affect; Area; Award; base; Basic Science; Biological Assay; Budgets; California; career; career development; Childhood; Chronic Disease; Clinical; Clinical Research; Collaborations; Communication; Communities; Decision Making; Development; Discipline; Discipline of Nursing; Education; Effectiveness; Ensure; Environment; Environmental Exposure; Environmental Health; epidemiology study; Evaluation; Faculty; faculty support; Fostering; Funding; Goals; Health; Health Sciences; improved; Infrastructure; innovation; Institution; Interdisciplinary Study; interest; Investigation; Investments; Leadership; Location; Longevity; Medical; Medical Students; meetings; member; Mentors; Mentorship; Modification; Monitor; multidisciplinary; National Institute of Environmental Health Sciences; NCI Scholars Program; operation; organizational structure; Pilot Projects; Planet Earth; Positioning Attribute; prevent; Prevention; Productivity; Professional Practice; Program Research Project Grants; programs; Publications; recruit; Reproduction; Research; Research Personnel; Research Project Grants; Resources; Role; San Francisco; Science; Scientist; Services; Structure; success; Sum; Technology; Training; Translating; Translational Research; Translations; Universities; web site; Work; ","Administrative Core","030284","EHS","Environmental Health Sciences Review Committee ","7072","A1","01","109687","67275","","176962"
"10071536","R01","AI","1","N","05/18/2020","05/18/2020","04/30/2021","855","R01AI154777","SCHOOLS OF MEDICINE","PA-19-056","1R01AI154777-01","NIAID:795805\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ORLANDO","UNITED STATES","OTHER BASIC SCIENCES","07","150805653","US","513805","UNIVERSITY OF CENTRAL FLORIDA","FL","328263231","PROJECT NARRATIVE Malaria is one of the major global health problem afflicting about 219 million people and killing 435,000 individuals annually. Because of the emergence of drug resistance parasites, current therapies for malaria are rapidly loosing their efficacy. The proposed research seeks to identify antimalarial lead compounds from fungal extracts effective against multidrug resistant malaria, thus contributing to the global malaria elimination campaign.","1902006 (contact); 8769887; ","CHAKRABARTI, DEBOPAM  (contact); CICHEWICZ, ROBERT HENRY;","O'NEIL, MICHAEL T","05/18/2020","04/30/2025","Address; Anti-Infective Agents; Antimalarials; Appearance; Area; Artemisinins; base; Bioinformatics; Biological; California; Cellular biology; cellular targeting; Cessation of life; Chemicals; Child; Childhood; Clinical; comparative; Copy Number Polymorphism; Country; CRISPR/Cas technology; Data; Development; Disease; drug discovery; Drug Kinetics; Drug resistance; Economics; Effectiveness; efficacy study; Evolution; experience; Florida; fungus; genome editing; genome sequencing; global health; Growth; High Pressure Liquid Chromatography; improved; In Vitro; in vivo; in vivo evaluation; Individual; Interdisciplinary Study; Laboratories; Lead; Libraries; Liver; macromolecule; Malaria; Measures; Mediating; Methods; Modeling; Molds; Molecular Target; mortality; Multi-Drug Resistance; Mus; Mutation; Myanmar; Natural Products; Natural Products Chemistry; Natural Selections; Nature; next generation; NMR Spectroscopy; novel; novel lead compound; novel therapeutics; Oklahoma; Parasite resistance; Parasites; Pharmaceutical Preparations; Pharmacology; pharmacophore; Phenotype; Population; Prevalence; Property; Proteins; Proteome; Research; Resistance; Resistance profile; resistant strain; Resolution; Resource Development; Resources; scaffold; screening; small molecule therapeutics; Source; Southeastern Asia; Specimen; Spectrometry, Mass, Electrospray Ionization; Structure; targeted treatment; Texas; Therapeutic; Time; Universities; Ursidae Family; Validation; Vietnam; whole genome; ","Novel Antimalarials from Fungi","154777","ZRG1","Special Emphasis Panel ","","","01","679619","116186","795805",""
"9901518","K24","DK","5","N","05/20/2020","04/01/2020","03/31/2021","847","K24DK103986","SCHOOLS OF MEDICINE","PA-14-047","5K24DK103986-05","NIDDK:126809\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","SEATTLE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","605799469","US","9087701","UNIVERSITY OF WASHINGTON","WA","981959472","PUBLIC HEALTH RELEVANCE: The purpose of this grant application is to provide Dr. Bryan Kestenbaum, MD MS, with the protected time needed to rigorously train and mentor future clinical researchers in Nephrology. Clinical research trainees who complete this mentorship program will possess the skills, knowledge and preliminary data needed to evolve into successful independent researchers who will advance their scientific field and continue the teaching cycle.","7765321; ","KESTENBAUM, BRYAN R;","ABBOTT, KEVIN C","07/01/2016","03/31/2021","Adult; African American; Applications Grants; Appointment; Arteriovenous fistula; Award; Biological Assay; Biometry; Cardiology; Cardiovascular system; career; Catabolism; Characteristics; Chronic Kidney Failure; Clinical; Clinical Research; cohort; Cohort Studies; Data; Data Analyses; design; disability; Disease Progression; Dose; Drug Kinetics; Educational process of instructing; Environment; Enzymes; Epidemiologist; Epidemiology; Event; exercise training; experience; Faculty; Failure; Fistula; functional independence; Funding; Future; Glomerular Filtration Rate; graduate student; Grant; hands on research; Hemodialysis; Imaging Device; improved; Individual; Infrastructure; interest; K-Series Research Career Programs; Kidney; Kidney Diseases; Kidney Failure; Knowledge; Lead; Mass Spectrum Analysis; Measures; medical schools; Medicine; meetings; Mentors; Mentorship; Metabolic; metabolic abnormality assessment; Metabolic Diseases; Metabolism; Methodology; Minerals; Mitochondria; Muscle Mitochondria; Nephrology; next generation; novel; Operative Surgical Procedures; Paper; patient oriented research; Patients; Pharmaceutical Preparations; Physical Performance; Physicians; Positioning Attribute; programs; Property; public health relevance; Publishing; Quality of life; Renal function; Research; Research Institute; Research Personnel; Research Support; Risk Factors; Scientist; Secure; Skeletal Muscle; skills; solute; Staging; success; Testing; Time; Training; Training Programs; Translating; Translational Research; Universities; Variant; Vascular Diseases; Washington; Work; ","Midcareer Investigator Award:  Metabolic Complications of Chronic Kidney Disease","103986","DDK","Kidney, Urologic and Hematologic Diseases D Subcommittee ","","","05","117416","9393","126809",""
"9962885","F32","GM","5","N","04/01/2020","05/20/2020","05/19/2021","859","F32GM133116","SCHOOLS OF ARTS AND SCIENCES","PA-18-670","5F32GM133116-02","NIGMS:65310\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","CAMBRIDGE","UNITED STATES","CHEMISTRY","07","001425594","US","4911501","MASSACHUSETTS INSTITUTE OF TECHNOLOGY","MA","021421029","PROJECT NARRATIVE Advancing infectious disease treatment and diagnosis would be significantly aided by strategies to identify benign and harmful microbes within populations. Since traditional methods are time consuming and costly, my objective is to develop chemical tools to detect mycobacteria, including the bacteria that cause tuberculosis, within mixed populations. I propose to leverage compounds that become fluorescent as the mycobacterial cell envelope is generated, which will give exquisite insight into cell envelope differences among bacterial species.","14292550; ","WUO, MICHAEL G;","YANG, JIONG","05/20/2019","05/19/2022","Antibiotics; Antigens; Antimycobacterial Agents; arabinogalactan; Bacillus; Bacteria; base; Benign; Biology; Cell division; Cell Division Process; cell envelope; cell growth; Cell Wall; Cells; Chemicals; Consumption; Corynebacterium; Corynebacterium glutamicum; cost; Data; design; Diagnosis; Diagnostic; Disease; Drug resistance; Early Diagnosis; Etiology; experimental study; Fatty Acids; flexibility; Fluorescence; Fluorescence-Activated Cell Sorting; fluorophore; Foundations; Genetic Determinism; Genomics; Genus Mycobacterium; Growth; Heterogeneity; Human; Hydrolysis; improved; Incidence; infectious disease treatment; insight; Kinetics; Label; Link; Lipids; Metabolic; Methods; Microbe; microbial community; Microscopy; Modeling; Modification; Molecular; Monitor; mortality; Multidrug-Resistant Tuberculosis; mycobacterial; Mycobacterium smegmatis; Mycobacterium tuberculosis; mycolate; Mycolic Acid; novel diagnostics; Phenotype; Physiology; Population; population based; Population Heterogeneity; Relapse; Reporting; Resistance; Route; Stress; Structure; Time; time use; tool; transcriptome sequencing; transcriptomics; Trehalose; Tuberculosis; Variant; ","Chemical probes of mycobacterial growth and persistence","133116","ZRG1","Special Emphasis Panel ","","","02","65310","","65310",""
"9925244","R01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","838","R01HL134801","","PA-13-302","5R01HL134801-04","NHLBI:389917\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","CINCINNATI","UNITED STATES","","01","071284913","US","615001","CINCINNATI CHILDRENS HOSP MED CTR","OH","452293039","PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is an incurable, disabling, and often fatal disease characterized by the distribution of fibrotic lesions predominantly in the peripheral areas of the lung. Validation of the functional association between WT1-driven transcriptional programs and fibroblast phenotypes in the pathology of IPF, may provide new targets for clinical interventions of IPF.","10511056; ","MADALA, SATISH K;","LIN, SARA","05/22/2017","04/30/2022","Adult; American; Area; Attenuated; aurora kinase A; base; Biochemical; Bioinformatics; Biological Assay; Bleomycin; Cell Culture Techniques; Cells; Cicatrix; Clinical; Complex; Coupled; Data; Deposition; design; Diagnosis; Disease; effective therapy; experimental study; Extracellular Matrix; Fibroblasts; Fibronectins; Fibrosis; Future; Gases; Gene Expression Regulation; Generations; Genes; Genetic; Genetic Transcription; Goals; Health; Hydroxyproline; idiopathic pulmonary fibrosis; Impairment; improved; In Vitro; in vivo; innovation; insight; Intervention; Knowledge; Lead; Lesion; Luciferases; Lung; Lung diseases; Medical; Mesenchymal; Mitotic; Molecular; mortality; mouse model; multidisciplinary; Mus; novel; novel therapeutic intervention; novel therapeutics; overexpression; Pathogenesis; Pathologic Processes; Pathology; Patients; Peripheral; Phenotype; Phosphotransferases; Play; Prevention; Process; Production; programs; promoter; Pulmonary Fibrosis; Pulmonary Pathology; Reporter; Reporting; Research; Respiratory physiology; Role; Structure of parenchyma of lung; Systems Biology; Techniques; Testing; therapeutic target; Time; Tissues; transcription factor; transcriptome sequencing; Transducers; Transforming Growth Factor alpha; Transgenic Mice; translational study; treatment strategy; Up-Regulation; Validation; WT1 gene; Zinc Fingers; ","WT1 REGULATION OF PULMONARY FIBROSIS","134801","LIRR","Lung Injury, Repair, and Remodeling Study Section ","","","04","265411","124506","389917",""
"9914073","R01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","837","R01HL139582","SCHOOLS OF MEDICINE","PA-16-160","5R01HL139582-03","NHLBI:403750\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BROOKLYN","UNITED STATES","ANATOMY/CELL BIOLOGY","09","040796328","US","5992616","SUNY DOWNSTATE MEDICAL CENTER","NY","112032012","Based on very promising preliminary results, we speculate that manipulation the PC composition on the membrane of macrophages and adipocytes through LPCAT3 regulation (gene knockout or overexpression) can influence inflammation and insulin signaling, thus influencing the development of atherosclerosis. We will evaluate these processes in this application. The outcomes of this study may well lead to a novel anti-atherogenic strategy for clinical use.","6189212; ","JIANG, XIAN-CHENG ;","LIU, LIJUAN","07/01/2018","04/30/2022","1-Phosphatidylinositol 3-Kinase; Acyltransferase; Adipocytes; Adipose tissue; Antiatherogenic; Arterial Fatty Streak; Atherosclerosis; base; Body Weight; Caveolae; CD80 gene; Cell membrane; cell type; Cells; Cellular Structures; chemokine; Chronic; Clinical; Closure by clamp; Coculture Techniques; cytokine; deacylation; Defect; Development; Diet; Disease; Dyslipidemias; Fatty Acids; Foam Cells; Glucose; glucose disposal; glucose metabolism; glucose tolerance; glucose uptake; Hematopoietic; High Fat Diet; Immune; Impairment; Infiltration; Inflammation; Inflammatory; inflammatory marker; Inflammatory Response; Insulin; Insulin Receptor; Insulin Resistance; insulin sensitivity; insulin signaling; insulin tolerance; Interleukin-6; ITGAM gene; knock-down; knockout gene; Knockout Mice; Lead; Lecithin; Link; Lipids; Lipolysis; Lipopolysaccharides; Low Density Lipoprotein Receptor; Lysophosphatidylcholines; macrophage; Mediating; Membrane; Membrane Lipids; Membrane Structure and Function; Metabolic; Metabolic Diseases; metabolic phenotype; Mitogen-Activated Protein Kinases; Mus; Myeloid Cells; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; novel; Obesity; Outcome Study; overexpression; Palmitates; Pathology; Pathway interactions; Peritoneal; Phenotype; PLA2G6 gene; Plasma; Polyunsaturated Fatty Acids; polyunsaturated phosphatidylcholine; Positioning Attribute; prevent; Process; Production; Protein Family; Protein Isoforms; protein-tyrosine kinase c-src; Proto-Oncogene Proteins c-akt; Reaction; receptor; recruit; Regulation; Saturated Fatty Acids; Signal Transduction; subcutaneous; System; Testing; TLR4 gene; TNF gene; Triglycerides; Visceral; ","Effects of PC remodeling on macrophages and adipocytes: its relevance to atherosclerosis","139582","AICS","Atherosclerosis and Inflammation of the Cardiovascular System Study Section ","","","03","250000","153750","403750",""
"10133843","U01","MH","3","N","05/18/2020","04/01/2020","03/31/2021","242","U01MH119737","","PA-18-591","3U01MH119737-02S1","NIMH:147664\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","PHILADELPHIA","UNITED STATES","","03","073757627","US","1499101","CHILDREN'S HOSP OF PHILADELPHIA","PA","191462305","PROJECT NARRATIVE Neuropsychiatric manifestations are common in Rare Genetic Disorders (RGDs), affecting brain development and functioning throughout the lifespan; copy number variants (CNVs) at 22q11.2 and 16p11.2 loci are among the most common RGDs impacting developmental psychopathology. We propose to capitalize on highly informative samples and integrate prospective dimensional and categorical phenotyping with whole genome sequencing across these reciprocal CNVs. This work will identify convergent risk mechanisms for developmental neuropsychiatric disorders that have relevance to the broader population.","11595875; ","MCDONALD-MCGINN, DONNA MARIE;","FRIEDMAN-HILL, STACIA","06/20/2019","03/31/2024","16p11.2; 22q11.2; adverse outcome; Affect; Algorithms; Anxiety; Anxiety Disorders; Architecture; Attention; Attention deficit hyperactivity disorder; Attentional deficit; autism spectrum disorder; base; Brain; brain behavior; case control; Categories; Clinical; clinical Diagnosis; clinical phenotype; clinical predictors; Cognition; Cognitive; cohort; Collaborations; Complement; Complex; Computing Methodologies; Copy Number Polymorphism; Custom; Data; Data Analytics; Development; Developmental Course; Developmental Delay Disorders; Diagnosis; Dimensions; Disease; Early Intervention; Emotional; Emotions; Environment; Environmental Risk Factor; Evaluation; experience; externalizing behavior; Family; Family member; Genes; Genetic; genetic architecture; Genetic Determinism; genetic pedigree; Genetic Predisposition to Disease; Genetic study; genetic variant; genome sequencing; genome wide association study; Genomics; Goals; Heterogeneity; Hyperactive behavior; Individual; Institution; Intellectual functioning disability; interest; International; Knowledge; large datasets; Lead; Literature; Longevity; Measures; Memory; Mental Depression; Mind; Modeling; Molecular; National Institute of Mental Health; Nature; neurobehavioral; neurobiological mechanism; Neurocognition; neuropsychiatric disorder; neuropsychiatry; Online Systems; Outcome; Patients; personalized approach; phenomics; Phenotype; Population; Positioning Attribute; processing speed; prospective; Psychiatric Diagnosis; Psychopathology; Psychotic Disorders; Public Domains; rare genetic disorder; rare variant; recruit; Recurrence; Resources; Risk; risk prediction model; Sampling; Schizophrenia; social; Social Behavior; Specificity; Structure; symptomatology; Symptoms; Syndrome; theories; tool; Variant; whole genome; Work; ","2/9: Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders.","119737","ZMH1","Special Emphasis Panel ","","S1","02","96005","51659","147664",""
"10069737","R01","AI","2","N","05/19/2020","05/19/2020","04/30/2021","855","R01AI112579","","PA-19-056","2R01AI112579-05A1","NIAID:542495\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","HACKENSACK","UNITED STATES","","05","042797571","US","3117901","HACKENSACK UNIVERSITY MEDICAL CENTER","NJ","076011915","CD8+ T lymphocytes are essential players in mounting protective cellular immune responses against pathogenic antigens and malignantly transformed cells. The transcription factor Tcf1 has critical roles in regulating the recall response by memory CD8+ T cells and enhancing functional restoration of exhausted CD8+ T cells. The proposed studies will provide rationales for utilizing Tcf1 and its downstream pathways to promote recall response and rectify T cell exhaustion to improve viral and cancer immunity.","8768164; ","XUE, HAI-HUI ;","PRABHUDAS, MERCY R","03/15/2015","04/30/2025","3-Dimensional; Acute; acute infection; Affect; antigen challenge; Antigens; ATAC-seq; base; BLR1 gene; cancer immunotherapy; CD8-Positive T-Lymphocytes; CD8B1 gene; Cell Cycle; cell transformation; Cells; Chromatin; Chromatin Loop; Chronic; chronic infection; cofactor; Communicable Diseases; cytotoxic; Dissection; DNase I hypersensitive sites sequencing; Ectopic Expression; Enhancers; Environment; Epigenetic Process; exhaust; exhaustion; Exhibits; Functional disorder; functional restoration; Funding; gain of function; Generations; Genetic Transcription; Genome; Glycolysis Induction; Glycolysis Pathway; Goals; Histone Deacetylase; immune checkpoint blockade; Immune response; Immunity; Impairment; improved; Infection; insight; Knowledge; Link; Malignant - descriptor; Malignant Neoplasms; Mature T-Lymphocyte; Memory; Modeling; Modification; Molecular; Nature; neoplastic cell; Output; pathogen; Pathogenicity; Pathway interactions; Phase; Phenotype; pre-clinical; Preventive vaccine; programs; Progress Reports; promoter; Research; response; Rest; Role; self-renewal; SELL gene; stem; Stem cells; stem-like cell; success; Systems Biology; T cell differentiation; T cell response; T cell transcription factor 1; T memory cell; T-Lymphocyte; T-Lymphocyte Subsets; Testing; Therapeutic; Thymocyte Development; Time; transcription factor; Transcriptional Regulation; transcriptome; transcriptomics; tumor; Vaccines; Viral; Viral Cancer; Virus Diseases; ","Tcf1 programs CD8 T cell responses to enhance viral and cancer immunity","112579","CMIA","Cellular and Molecular Immunology - A Study Section ","","A1","05","355921","186574","542495",""
"9912838","R01","HL","5","N","05/21/2020","05/01/2020","04/30/2021","837","R01HL138332","SCHOOLS OF PUBLIC HEALTH","PAR-15-279","5R01HL138332-03","NHLBI:758721\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","MINNEAPOLIS","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","05","555917996","US","1450402","UNIVERSITY OF MINNESOTA","MN","554552070","Project Narrative: This study addresses the significant public health problem of uncontrolled hypertension and can prevent stroke and improve cardiovascular health while reducing costs. The current U.S. annual estimated cost of hypertension is $51 billion. Results from this study will provide evidence for the use of readily available mobile health technology for bridging the guideline-to-practice gap in hypertension treatment. Our study will be implemented in low resource health systems serving minority groups. We also include an economic analysis showing the cost-effectiveness of our mobile health technology based care model.","8031707; ","LAKSHMINARAYAN, KAMAKSHI ;","EINHORN, PAULA T","07/18/2018","04/30/2023","active method; Address; Adherence; Adult; Adverse event; African American; Age; American Heart Association; arm; base; Blood Pressure; Blood Pressure Monitors; Cardiovascular Diseases; cardiovascular disorder risk; cardiovascular health; care providers; Caring; Cellular Phone; Client satisfaction; Clinic Visits; Clinical; clinical care; Clinical effectiveness; Communities; cost; cost effectiveness; Cost Effectiveness Analysis; Data; Databases; Early Intervention; economic impact; Economics; Effectiveness; Emergency Care; Event; experience; Federally Qualified Health Center; Focus Groups; Frequencies; Goals; Guidelines; health care service utilization; health disparity; health economics; Health Resources; Health Status; Health system; Health Technology; Healthcare; high risk; Home Care Services; hospitalization rates; Hypertension; hypertension control; hypertension treatment; improved; Intervention; intervention participants; Latino; Literature; Low income; Measures; Medical Care Team; medication compliance; member; mHealth; Minority; minority communities; Minority Groups; Modeling; Monitor; mortality; Participant; Patient Care; Patient Education; Patients; Perception; Pharmaceutical Preparations; Pharmacists; Physicians; Pilot Projects; Population; Population Heterogeneity; Primary Health Care; Probability; Provider; Public Health; Quality-Adjusted Life Years; Race; Randomized; Reading; Recording of previous events; recruit; Research; Research Personnel; response; Risk Factors; satisfaction; Self Blood Pressure Monitoring; Self Efficacy; Site; Specific qualifier value; Stroke; Stroke prevention; stroke risk; stroke survivor; Structure; Subgroup; Surveys; Technology; Telephone; treatment as usual; two-arm trial; urgent care; usability; Visit; Wireless Technology; ","mGlide RCT: A Clinical Glide Path to Close the Guideline-to-Practice Gap in HTN Management","138332","ZRG1","Special Emphasis Panel ","","","03","557854","200867","758721",""
"9928488","R01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","838","R01HL136449","","PA-16-160","5R01HL136449-03","NHLBI:611477\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","DENVER","UNITED STATES","","01","076443019","US","5720901","NATIONAL JEWISH HEALTH","CO","802062761","PROJECT NARRATIVE Chronic lung disease, including fibrosis, is the fourth leading cause of mortality worldwide, complicated by pulmonary vascular dysfunction (PVD), characterized by remodeling and loss of microvessels, which substantially worsens prognosis and limits survival. We have challenged existing paradigms and identified adult pulmonary resident mesenchymal pericyte progenitors (ABCG2pos MPC) that regulate microvascular function during tissue homeostasis and are also capable of regulating the extent of vasculopathy and the development of PVD and fibrosis in lung tissue. Therefore, the lung MPC is a previously unstudied target that should be exploited to identify new mechanisms and therapeutic targets relevant to the pathobiology of fibrosis.","6770158; ","MAJKA, SUSAN M;","LIN, SARA","02/15/2018","04/30/2022","ABCG2 gene; Adipose tissue; Adult; Affect; angiogenesis; Attenuated; beta catenin; Bleomycin; Blood Vessels; Cell Communication; cell fate specification; Cells; chemotherapeutic agent; Chronic; Chronic lung disease; Collagen; comorbidity; Conflict (Psychology); Coupled; Data; Deposition; Development; Disease; Disease Progression; Dose; Epithelial Cells; Etiology; Fibrosis; Flow Cytometry; Functional disorder; Genes; Homeostasis; Human; Hyperplasia; In Vitro; in vivo; inhibitor/antagonist; Injury; Kidney; Knowledge; Ligands; Lung; Maintenance; Mesenchymal; Microvascular Dysfunction; Modeling; mortality; mouse model; Mus; neovascularization; novel; outcome forecast; palliative; paracrine; Pathologic; Pathology; Patients; Pericytes; Pharmaceutical Preparations; Phenotype; Prevalence; progenitor; Pulmonary Fibrosis; receptor; Recovery; Regulation; repaired; Rodent Model; Severities; Signal Pathway; Signal Transduction; Skin; Smooth Muscle Myocytes; Structure; Structure of parenchyma of lung; Systemic Scleroderma; Tamoxifen; targeted treatment; Testing; Therapeutic; therapeutic target; Tissues; tool; Uterus; vascular abnormality; Vascular Diseases; Vascular Endothelium; Vegf inhibition; WNT Signaling Pathway; ","Lung MSC regulate angiogenesis and repair during fibrosis","136449","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","","03","389640","221837","611477",""
"10146806","R01","AI","3","N","05/22/2020","05/22/2020","02/28/2021","855","R01AI124465","SCHOOLS OF MEDICINE","PA-18-591","3R01AI124465-05S1","NIAID:342914\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW YORK","UNITED STATES","PHARMACOLOGY","13","078861598","US","3839801","ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI","NY","100296574","PROJECT NARRATIVE Hyperactivation of pro-inflammatory cytokines by SARS-CoV-2 infection has been recognized as the major contributor to acute respiratory distress syndrome, the leading cause of COVID-19 mortality. Our study has uncovered the mechanism underlying transcriptional activation of these inflammatory cytokines. In this study, we will identify and repurpose FDA-approved drugs to block the uncontrolled cytokine release as a new treatment for COVID-19 patients.","2793440; ","ZHOU, MING-MING ;","MALLIA, CONRAD M","05/22/2020","02/28/2021","2019-nCoV; Acute respiratory failure; adaptive immunity; Address; Administrative Supplement; Adult Respiratory Distress Syndrome; Antiviral Agents; Autoimmune Diseases; Award; Binding; biological systems; Biology; BRD2 gene; Bromodomain; CCL2 gene; CD4 Positive T Lymphocytes; Cell Differentiation process; Cell Line; Cells; Characteristics; Chemicals; Chromatin; Clinical; Clinical Trials; cohesin; Colitis; Complex; COVID-19; cytokine; cytokine release syndrome; design; Development; Disease; Disease Outbreaks; effective therapy; Enhancers; Ensure; epigenetic drug; epigenomics; FDA approved; Funding; Gene Expression Profile; gene interaction; Genes; Genetic Enhancer Element; Genetic Transcription; Genomics; Goals; Grant; granulocyte; Granulocyte-Macrophage Colony-Stimulating Factor; GTP-Binding Protein alpha Subunits, Gs; Helper-Inducer T-Lymphocyte; Histones; Human; Immune; Immune response; Impairment; In Vitro; in vivo; Individual; Infection; Inflammation; Inflammatory; Influenza; inhibitor/antagonist; insight; interest; Interferon Type II; Interleukin-10; Interleukin-17; Interleukin-6; Investigation; Knowledge; Life; Ligands; Lung; Lysine; macrophage; Medical; Modeling; Molecular; mortality; Mus; National Institute of Allergy and Infectious Disease; new therapeutic target; next generation; NF-kappa B; novel; novel coronavirus; novel therapeutics; pandemic disease; Parents; Patients; Peripheral Blood Mononuclear Cell; Pharmaceutical Preparations; Phase; Phosphorylation; Play; Positive Transcriptional Elongation Factor B; programs; promoter; Protein Family; Proteins; recruit; Regulation; Reporting; Research Project Grants; Respiration Disorders; response; RNA; RNA Polymerase II; Role; SARS coronavirus; Site; small molecule; Speed; STAT3 gene; Stat3 Signaling Pathway; Structure; Tertiary Protein Structure; Testis; Tissues; TNF gene; Transcription Elongation; transcription factor; Transcriptional Activation; Transcriptional Regulation; U-Series Cooperative Agreements; United States National Institutes of Health; Vaccines; Virus; Work; ","Mechanism of BET Proteins in Th17 Cell Differentiation","124465","","","","S1","05","202309","140605","342914",""
"9852901","P20","GM","1","N","05/21/2020","12/01/2019","11/30/2020","","P20GM130448","","PAR-18-266","1P20GM130448-01A1","NIGMS:220203\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MANHATTAN","UNITED STATES","","01","929773554","US","4202801","KANSAS STATE UNIVERSITY","KS","665062504","Project narrative: The proposed study will develop and test rational design strategies for live-attenuated vaccines for flaviviruses that are important to human health. The results will enhance our ability to mitigate and control diseases caused by emerging and re-emerging pathogenic flaviviruses.","14419775; ","HUANG, YAN-JANG ;","","","","Animal Model; Antiviral Agents; Attenuated; Attenuated Live Virus Vaccine; attenuation; base; Chimeric Proteins; Clinical Trials; Communicable Diseases; Complement; Complementary DNA; Consensus; Consensus Sequence; Conserved Sequence; Data; design; Development; dimer; Disease; disorder control; Encephalitis; Engineering; env Gene Products; Flavivirus; Flavivirus Infections; flexibility; Future; Genes; Genetic; Genomic Segment; Glycine; Goals; Growth; Health; Human; human disease; Hydrophobic Interactions; Hydrophobicity; Immunization; immunogenicity; Impairment; In Vitro; in vivo; Incidence; Individual; Infection; Japanese Encephalitis; Japanese encephalitis virus; Knowledge; late endosome; Lead; Length; Membrane Fusion; Modeling; monomer; mouse model; Movement; Mus; Mutagenesis; mutant; Mutate; Mutation; Pathogenesis; Pathogenicity; Pattern; Peptides; Phenotype; premature; Process; Publications; receptor; receptor binding; Reporter; reverse genetics; Safety; Serial Passage; Side; Standardization; Structure; success; Surface; System; Tertiary Protein Structure; Testing; The Sun; tissue tropism; transmission process; vaccine candidate; Vaccine Design; Vaccines; vaccinology; Viral; Viral Hemorrhagic Fevers; Virion; Virulence; Virus; West Nile virus; Yang; Yellow Fever; Yellow fever virus; Zoonoses; ","Rational Design of live-attenuated vaccines for flaviviruses","130448","ZGM1","Special Emphasis Panel ","7579","A1","01","147140","73063","","220203"
"10123197","R01","CA","7","N","05/19/2020","05/19/2020","11/30/2020","395","R01CA194090","SCHOOLS OF MEDICINE","PA-13-302","7R01CA194090-06","NCI:346556\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","ALBUQUERQUE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","01","829868723","US","10021612","UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR","NM","871310001","PUBLIC HEALTH RELEVANCE:  Myxoma virus is a rabbit specific poxvirus which displays curative potential for the treatment of human multiple myeloma in preclinical models. However, the translation of this therapy is hindered by our lack of understanding concerning the molecular mechanisms involved. The current proposal is therefore designed to advance the use of myxoma as a novel treatment for myeloma by enhancing our understanding of the molecular mechanisms involved in treatment and how these mechanisms influence outcomes.","10501140; ","BARTEE, ERIC CARTER;","SALOMON, RACHELLE","12/01/2015","11/30/2020","Adverse event; Apoptotic; Autologous Transplantation; base; Binding; Cancerous; Cell Death; Cells; Cellular biology; Clinical; Data; Defect; Dependence; design; Diagnosis; Disease; Dose; Genetic; Goals; Hematopoietic; Hematopoietic Neoplasms; Human; Immune response; Immune system; Immunologics; improved; improved outcome; In Vitro; in vivo; intravenous injection; Light; Malignant Neoplasms; Mediating; Methods; Modality; Molecular; Molecular Biology; Multiple Myeloma; Myxoma; Myxoma virus; Nature; Non-Malignant; Normal Cell; novel; novel therapeutics; Oncolytic; Oncolytic viruses; Oryctolagus cuniculus; Outcome; Pathway interactions; patient response; Patients; Play; Population; Poxviridae; Pre-Clinical Model; prevent; Property; Proteins; Public Health; public health relevance; Recombinant Proteins; Relapse; Residual state; Residual Tumors; Resistance; response; Role; Sampling; Site; Solid Neoplasm; success; Survivors; Systemic disease; Therapeutic; Translating; Translations; Tumor Debulking; Viral; Viral Envelope Proteins; Virus; Virus Shedding; Work; ","Treatment of multiple myeloma using oncolytic myxoma virus","194090","DT","Developmental Therapeutics Study Section ","","","06","228750","117806","346556",""
"10050702","R01","MH","1","N","05/20/2020","05/20/2020","02/28/2021","242","R01MH120991","","PA-19-056","1R01MH120991-01A1","NIMH:858678\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BELMONT","UNITED STATES","","05","046514535","US","1876801","MCLEAN HOSPITAL","MA","024781064","NARRATIVE These studies will examine neural circuit-based mechanisms for understanding emotional instability across appetitive and aversive behaviors in BD. Focus on circuit- and cell-specific roles of Wnt/? catenin and stress/reward-related molecular pathways may be transformative in our understanding of BD and point to novel interventions and therapeutic approaches.","6619244 (contact); 9869798; 14312630; ","BERRETTA, SABINA  (contact); MCCARROLL, STEVEN ANDREW; RESSLER, KERRY J.;","MEINECKE, DOUGLAS L","05/20/2020","02/28/2025","Affect; Affective; Algorithms; Amygdaloid structure; Anhedonia; Anti-Anxiety Agents; Anxiety; Appetitive Behavior; Arousal; Autopsy; base; Behavior; beta catenin; Bipolar Disorder; Cell Nucleus; cell type; Cells; Clinical; Data; Desire for food; Dimensions; Disease; Electronic Health Record; Emotional; Expression Profiling; Felis catus; Fingerprint; Fright; Gene Expression; Genetic Models; Goals; Health; Hormones; Human; Image; Impulsive Behavior; Intercalated Cell; Intervention; knock-down; Knock-out; Label; Lateral; Link; Lithium; Manic; Mental Depression; Mental disorders; Messenger RNA; Modeling; Molecular; Molecular Abnormality; Molecular Profiling; motivated behavior; mouse genetics; Mus; National Institute of Mental Health; neural circuit; neuronal circuitry; Neurons; Neurotensin Receptors; novel; novel therapeutic intervention; Nucleus Accumbens; optogenetics; Pathway interactions; Pattern; Phenotype; pleasure; Population; protein expression; Proteins; Research Domain Criteria; Resolution; response; reward processing; Rewards; RNA; Rodent; Role; Severities; Signal Transduction; Signaling Molecule; single-cell RNA sequencing; Stress; Symptoms; System; Testing; Therapeutic; transcriptome sequencing; WNT Signaling Pathway; ","Dysregulation of Appetitive & Aversive Amygdala Circuits in Bipolar Disorder","120991","PMDA","Pathophysiological Basis of Mental Disorders and Addictions Study Section ","","A1","01","614695","243983","858678",""
"10127234","R01","AI","7","N","05/19/2020","04/01/2020","08/31/2021","855","R01AI139874","","PA-18-484","7R01AI139874-03","NIAID:1\","Non-SBIR/STTR RPGs","2019","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","HACKENSACK","UNITED STATES","","05","042797571","US","3117901","HACKENSACK UNIVERSITY MEDICAL CENTER","NJ","076011915","Follicular helper T (TFH) cells are critical for helping B cells to produce high affinity antibodies in response to pathogen infections. This project will investigate the regulatory roles of Ezh2 in activating TFH program during acute response phase and generation of long-lasting memory TFH cells. The proposed studies will provide rationales for utilizing Ezh2 and its downstream pathways to modulate TFH and antibody responses during prime and boost vaccination.","8705788; 8768164 (contact); ","PENG, WEIQUN ; XUE, HAI-HUI  (contact);","JOHNSON, DAVID R","09/24/2018","08/31/2023","","Ezh2 regulates follicular helper T cell differentiation","139874","CMIA","Cellular and Molecular Immunology - A Study Section ","","","03","1","0","1",""
"10048452","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI154353","SCHOOLS OF MEDICINE","PA-19-053","1R21AI154353-01","NIAID:236250\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LA JOLLA","UNITED STATES","PEDIATRICS","52","804355790","US","577507","UNIVERSITY OF CALIFORNIA, SAN DIEGO","CA","920930934","Project Narrative EoE is an allergic disease of increasing prevalence that leads to esophageal rigidity and narrowing. Complications occur via tissue remodeling which includes subepithelial fibrosis. In this application we will use EoE and normal fibroblasts and their extracellular matrixes to understand molecular markers that influence fibroblast function and utilize potential anti-remodeling compounds in a fibroblast-based personalized medicine platform.","10167620; ","ACEVES, SEEMA S;","MINNICOZZI, MICHAEL","05/22/2020","04/30/2022","Allergic; Allergic Disease; Allergic inflammation; angiogenesis; Antigens; Autologous; Automobile Driving; base; Biological Assay; Biological Models; Biopsy; CD47 gene; cell motility; Cell physiology; Cells; Cellular Structures; Child; Childhood; Chronic; Clinical; cohort; Collagen; cytokine; Data; Deglutition; Disease; drug development; druggable target; Eosinophilia; Eosinophilic Esophagitis; eosinophilic inflammation; Esophagus; experimental study; Expert Systems; Extracellular Matrix; fibrillogenesis; Fibroblasts; Fibrosis; Food; Functional disorder; Growth; Healthcare; Histologic; Human; imaging probe; In Vitro; in vivo; individualized medicine; Inflammation; inhibitor/antagonist; insight; Knowledge; longitudinal database; Molecular; molecular marker; motility disorder; Muscle function; muscle hypertrophy; new therapeutic target; novel; novel strategies; novel therapeutics; Outcome; Pathologic; Patient Care; Patients; Pattern; personalized medicine; Phenotype; phenotypic biomarker; Play; predictive marker; Prevalence; Production; Protein Analysis; protein expression; Proteins; Proteome; Proteomics; receptor; Risk; Role; Scientist; screening; Severities; Severity of illness; Smooth Muscle; Smooth Muscle Actin Staining Method; success; Symptoms; Testing; TGFB1 gene; therapy resistant; Thrombospondin 1; Tissues; translational physician; treatment response; Vomiting; ","Probing the Mechanisms of Fibroblast-Extracellular Matrix Interactions to Assess Disease Severity in Allergic Eosinophilic Esophagitis","154353","ZRG1","Special Emphasis Panel ","","","01","150000","86250","236250",""
"9924649","P20","NR","5","N","05/22/2020","05/01/2020","04/30/2021","361","P20NR016599","SCHOOLS OF NURSING","RFA-NR-16-001","5P20NR016599-05","NINR:367701\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF NURSING RESEARCH","","HADLEY","UNITED STATES","NONE","02","153926712","US","850904","UNIVERSITY OF MASSACHUSETTS AMHERST","MA","010359450","Project Narrative More than 90% of individuals over 65 in the United States have health issues that require daily maintenance and more than 33% of older individuals have functional impairments that affect their self-management abilities. We propose a new, innovative UMass Center for Building the Science of Symptom Self-Management (UManage Center) to develop the science of symptom self-management using wearable and handheld technologies. Using a functional approach to improve individuals' self- management of the symptoms of fatigue and impaired sleep through the use of wearable and handheld devices could reduce healthcare costs by reducing exacerbations of chronic conditions.","8115068; ","JACELON, CYNTHIA S;","KEHL, KAREN","07/26/2016","04/30/2021","Activities of Daily Living; Acute; Admission activity; Adult; Affect; Applications Grants; Arthritis; base; Behavior; Biological Sciences; Brain; Chronic; Chronic Disease; Collaborations; college; Communities; computer science; Computers; Congestive Heart Failure; Consultations; cost; daily functioning; design; Development; Devices; Diabetes Mellitus; disabling symptom; Discipline of Nursing; Disease; Elderly; Engineering; experience; Family; Fatigue; Feedback; Fibromyalgia; Fostering; functional disability; Goals; handheld equipment; Health; Health Care Costs; Health care facility; Health Personnel; health plan; Healthcare; Healthcare Systems; Healthy People 2020; Hospital Costs; Human; improved; Individual; Industrialization; Informatics; Infrastructure; innovation; Institutes; Intervention; Lead; Long-Term Care; Maintenance; Malignant Neoplasms; Massachusetts; Mechanics; Medical center; Mentors; Monitor; multiple chronic conditions; Multiple Sclerosis; Natural Sciences; negative affect; Obstructive Sleep Apnea; Patient Self-Report; persistent symptom; Physiological; Pilot Projects; Postpoliomyelitis Syndrome; prevent; programs; psychologic; Quality of life; Reporting; Research Personnel; response; Science; Secondary to; Self Management; Sleep; Sleep disturbances; Stroke; symptom management; symptom science; symptom self management; Symptoms; System; Technology; Testing; Time; United States; Universities; wearable device; wearable sensor technology; Work; Writing; ","UMass Center for Building the Science of Symptom Self-Management (UManage Center)","016599","ZNR1","Special Emphasis Panel ","","","05","296590","176471","367701",""
"10150206","R01","AI","7","N","05/19/2020","04/01/2020","11/30/2020","855","R01AI052056","SCHOOLS OF MEDICINE","PA-18-590","7R01AI052056-19","NIAID:699291\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","WASHINGTON","UNITED STATES","PATHOLOGY","98","043990498","US","2863301","GEORGE WASHINGTON UNIVERSITY","DC","200520042","Project Narrative We will investigate control of antibodies information vaccine-induced antibody responses and innate immune responses associated with the If we are successful in defining the nature and the targets of these and the novel innate immune response pathways involved in viral control, incorporating this into vaccine design may facilitate the eventual development of an HIV v accine. SIVmac239 replication.","6106501; ","WATKINS, DAVID I;","LAWRENCE, DIANE M","04/01/2003","11/30/2023","Address; Animals; Antibodies; Antibody Response; Antiviral Agents; Binding; Biological Assay; CD8-Positive T-Lymphocytes; Cells; chemokine; Chronic Phase; cohort; cytokine; Cytomegalovirus; Development; Dose; Effector Cell; Genes; Grant; HIV; Immune response; Immune Response Genes; Immune signaling; Immunoglobulin G; Individual; Infection; Inflammasome; Innate Immune Response; Light; Macaca; Macaca mulatta; Mediating; Memory B-Lymphocyte; Monitor; Monoclonal Antibodies; Nature; novel; Outcome; Pathway interactions; Phagocytosis; Pharmacotherapy; polyclonal antibody; prevent; RNA; Serum; SIV; T cell response; T-Cell Activation; Testing; Toll-Like Receptor Pathway; transcriptome; Vaccinated; Vaccine Design; vaccine trial; Vaccines; Variant; Viral; Virus; Virus Replication; ","The functional significance of CTL escape","052056","VACC","HIV/AIDS Vaccines Study Section ","","","19","538842","160449","699291",""
"9921438","P30","EY","5","N","05/20/2020","04/01/2020","03/31/2021","","P30EY008098","","PAR-17-322","5P30EY008098-32","NEI:27434\","RESEARCH CENTERS","2020","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","","7892660; ","SMITH, MATTHEW A;","","","","Conceptions; Core Grant; Custom; design; Development; Devices; Equipment; experimental study; Faculty; Goals; Imagination; Laboratories; Methods; Production; prototype; Research; Research Personnel; Research Project Grants; Resources; Training; Vision; Vision research; ","Custom Fabrication Core","008098","ZEY1","Special Emphasis Panel ","5953","","32","17530","9904","","27434"
"9877511","R01","ES","1","N","05/20/2020","05/20/2020","02/28/2021","113","R01ES031378","","PA-19-056","1R01ES031378-01","NIEHS:563289\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES","","COLUMBUS","UNITED STATES","","03","832127323","US","6218701","OHIO STATE UNIVERSITY","OH","432101016","Project Narrative Ozone exposure increases pulmonary inflammation and there are currently no available therapeutic strategies to limit the adverse effects of ozone. This application studies how dietary administration of docosahexaenoic acid (DHA), a nutrient that is generally deficient in the western diet, can improve pulmonary inflammation through two distinct mechanisms. Completion of this proposal will set the basis for improved dietary strategies to improve pulmonary outcomes upon ozone exposure.","9790569 (contact); 7076663; ","GOWDY, KYMBERLY MAE (contact); SHAIKH, SAAME R;","NADADUR, SRIKANTH","05/20/2020","02/28/2025","Acute; Adverse effects; air filter; Air Pollutants; Air Pollution; Alveolar Macrophages; Apoptotic; Area; base; Biochemical; Biophysics; Cell membrane; Cells; chemokine; Cholesterol; Chronic; Clinical; Complex; Consumption; cytokine; Data; Diet; Dietary Administration; Docosahexaenoic Acids; Environmental Pollutants; Exposure to; FPR2 gene; Health; human model; imaging approach; Immunology; improved; In Vitro; Incidence; Individual; Inflammation; Inflammatory; Inflammatory Response; Inhalation Toxicology; Injury; innovation; Intake; Knockout Mice; Link; lipid mediator; Lung; Lung diseases; Lung Inflammation; lung injury; macrophage; Mediating; Membrane; Membrane Microdomains; methyl-beta-cyclodextrin; Microscopy; Morbidity - disease rate; multidisciplinary; Mus; novel therapeutics; Nutrient; Nutritional Biochemistry; Omega-3 Fatty Acids; Outcome; Ozone; ozone exposure; Phenotype; Population; prevent; Production; Public Health; Pulmonary Inflammation; quantitative imaging; receptor; Recommendation; recruit; Reporting; Resolution; Role; Signal Transduction; Sorting - Cell Movement; Source; Structure; Supplementation; targeted treatment; Testing; Therapeutic; TLR4 gene; western diet; ","Dietary DHA mitigates ozone induced pulmonary inflammation","031378","SIEE","Systemic Injury by Environmental Exposure ","","","01","452469","110820","563289",""
"9912200","K24","MH","5","N","05/18/2020","05/01/2020","04/30/2021","242","K24MH110807","","PA-16-206","5K24MH110807-04","NIMH:188938\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","Narrative: Schizophrenia affects 1% of the population, yet, its neurobiology, as well as longitudinal natural course are not known. K24 will help support mentoring and training of both the PI and the talented junior clinical scientists in translational research aimed at understanding biological mechanisms of brain pathology affecting connectivity in schizophrenia.","8476522; ","KUBICKI, MAREK ;","CHAVEZ, MARK","05/09/2017","04/30/2022","Acute; Affect; Aging; Animals; Antipsychotic Agents; Appointment; Architecture; Award; Axon; base; Biological; Biological Markers; Brain; Brain Pathology; career; career development; cellular pathology; Chronic Schizophrenia; Clinic; Clinical; Collaborations; Communication; Data; data acquisition; Data Set; Development; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; doctoral student; early onset; extracellular; first episode schizophrenia; Foundations; Funding; General Hospitals; Generations; Goals; Grant; gray matter; Head; Hospitals; Image; Knowledge; Laboratories; large datasets; Ligand Binding; Macaca mulatta; Magnetic Resonance Imaging; Massachusetts; mathematical model; Measures; medical schools; Mentors; Mentorship; Methods; Microglia; mid-career faculty; Monitor; Multimodal Imaging; Myelin; National Institute of Mental Health; Nature; Nerve Degeneration; neurobiological mechanism; Neurobiology; neuroimaging; neuroimaging marker; neuroinflammation; neuroinformatics; Neurons; neuropsychiatric disorder; Neurosciences; Neurotransmitters; novel; Outcome; parent grant; Parents; Pathologic; Pathology; patient oriented; patient oriented research; Patients; Population; Positron-Emission Tomography; Postdoctoral Fellow; Probability; Process; programs; Psychiatry; Psychotic Disorders; radiologist; Radiology Specialty; Research; Research Personnel; Research Support; Research Training; Risk; Role; Scanning; Schizophrenia; Scientist; Senior Scientist; Signal Transduction; skills; Solid; Statistical Models; Students; success; summer student; Supervision; Symptoms; Synapses; Syndrome; Talents; Techniques; Testing; theories; Time; TimeLine; tool; Training; Translating; Translational Research; treatment strategy; undergraduate student; United States National Institutes of Health; Validation; Visit; Water; white matter; white matter change; Woman; Work; ","Mentoring and Neuroimaging Research on White Matter Pathology in Schizophrenia","110807","NPAS","Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section ","","","04","174943","13995","188938",""
"9854040","U54","AG","1","N","05/20/2020","09/01/2019","08/31/2020","","U54AG062322","","RFA-OD-19-013","1U54AG062322-01A1","NIA:403306\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE ON AGING","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","NARRATIVE During perimenopause, women experience dramatic changes that extend beyond cessation of menses, including alterations that accelerate the aging process and elevate risks for cardiometabolic diseases cognitive impairment, and dementia as well as Alzheimer?s disease. This Project will investigate physiological and social stressors in early life and around the time of pregnancy as predictors of body composition, neuropsychiatric symptoms, and sleep duration and quality in mid-life. Results from the proposed series of investigations have the potential to influence clinical care of aging women through informing both guidelines on screening and long- term follow-up from the reproductive years into menopause and research priorities related to cardiometabolic diseases and dementia risk profiles in women.","7370785; ","OKEN, EMILY ;","","","","actigraphy; AD pathology; Address; Adipose tissue; Adult; adverse childhood events; Affect; Age; Aging; Alzheimer's Disease; Anxiety; Attention; Behavior; Behavioral; Blood Pressure; Body Composition; body system; cardiometabolic risk; cardiometabolism; Cardiovascular Diseases; cardiovascular disorder risk; Cerebrovascular Disorders; Cholesterol; clinical care; cognitive function; cohort; Data; data resource; Dementia; dementia risk; depressive symptoms; Development; diaries; Disease; disorder risk; early pregnancy; Environmental Risk Factor; experience; Exposure to; Fasting; follow-up; Future; Genetic; Gestational Diabetes; gestational weight gain; Glucose; Goals; Guidelines; Health; Hour; Impaired cognition; Insulin; interest; Investigation; Life; Lipids; Longitudinal Studies; Longterm Follow-up; Measures; Mediating; Memory; men; Menopause; Menstruation; Mental Depression; Metabolic; Methods; middle age; Neurobehavioral Manifestations; neuropsychiatric symptom; neuropsychiatry; neuroregulation; Non-Insulin-Dependent Diabetes Mellitus; Obesity; OGTT; Outcome; Outcome Assessment; Perimenopause; Perinatal; physiologic stressor; Physiological; postpartum weight; Pregnancy; pregnancy disorder; Premenopause; Process; prospective; Quality of life; Questionnaires; racism; recruit; reproductive; reproductive senescence; Research Priority; Risk; Risk Factors; Roentgen Rays; screening; Series; sex; Sleep; Sleep disturbances; social; Statistical Data Interpretation; Stress; stressor; study population; Symptoms; synergism; Testing; Time; vascular cognitive impairment and dementia; Vasomotor; Violence; Visceral; waist circumference; Weight; Weight Gain; Woman; Work; Wrist; ","Physiologic and social stressors and health during menopausal transition","062322","ZRG1","Special Emphasis Panel ","7959","A1","01","280182","123124","","403306"
"9933081","R01","HL","5","N","05/20/2020","05/01/2020","04/30/2021","839","R01HL129141","SCHOOLS OF MEDICINE","PA-16-160","5R01HL129141-03","NHLBI:500223\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","ATLANTA","UNITED STATES","PEDIATRICS","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","Project Narrative Gene and immunotherapy, in which cells are ?infected? with engineered viruses to correct genetic defects or attack cancer cells, have made remarkable strides towards curing genetic diseases and cancer, but these processes are extremely inefficient; large amounts of virus are needed, which currently renders these life-saving therapies infeasible for large scale clinical translation. To address this issue, we will apply our novel microfluidic technology that incorporates basic mass transfer and fluid mechanics principles to increase gene therapy efficiency. More specifically, we will leverage those principles to scale up our microfluidic systems such that we can achieve the efficiency to genetically infect a clinically relevant number of hematopoietic stem cells and T cells, which will enable gene therapy to reach the patient bedside at a large scale.","2123578; 7889281 (contact); 1939665; ","DOERING, CHRISTOPHER BRADLEY; LAM, WILBUR A (contact); SPENCER, H TRENT;","WARREN, RONALD Q","05/01/2018","04/30/2022","Achievement; Acute; Address; Adjuvant; Affect; Area; base; Binding; Biochemical; Biological; Biomedical Engineering; Biophysics; cancer cell; Cations; CD34 gene; Cell membrane; Cell physiology; Cell Survival; Cell Therapy; Cells; Charge; chemotherapy; chimeric antigen receptor; chimeric antigen receptor T cells; Clinical; clinical application; clinical development; clinical translation; Clinical Trials; clinically relevant; Collaborations; commercialization; Data; design; Development; Devices; Disease; Drug resistance; Effectiveness; Electrostatics; Engineering; Factor VIII; Fibronectins; flasks; Gases; gene therapy; Gene Transduction Agent; Gene Transfer; gene transfer vector; Genes; Genetic; Genetic Diseases; Genetic Vectors; Hematology; Hematopoietic; Hematopoietic stem cells; Hemophilia A; HIV-1; Human; human disease; Immobilized Cells; Immunotherapy; improved; Infection; Kinetics; Laboratories; Lentivirus Vector; Life; Ligands; Liquid substance; Logistics; Mainstreaming; Malignant Neoplasms; Measures; Mechanics; Mediating; Methods; Microfluidic Microchips; microfluidic technology; Microfluidics; Mind; Modeling; Modification; Molecular; Mutation; next generation; novel; particle; patient population; Patients; Peptides; Performance; Permeability; Polymers; pre-clinical; preclinical development; Probability; Process; Production; programs; Protamine Sulfate; Protocols documentation; receptor; Reporter; Reporting; Research; Research Project Grants; Retrieval; Safety; Savings; scale up; Sirolimus; stemness; success; Surface; Suspensions; System; T-Cell Leukemia; T-Lymphocyte; Technology; Testing; Time; Toxic effect; transduction efficiency; Transduction Gene; Transgenes; Translating; Transplantation; vector; Viral; Viral Genes; Virus; Waste Products; ","A microfluidics-based paradigm for clinical lentivector gene transfer","129141","GDD","Gene and Drug Delivery Systems Study Section ","","","03","320656","179567","500223",""
"10147497","R01","HL","3","N","05/19/2020","05/20/2020","05/31/2020","838","R01HL136734","OVERALL MEDICAL","PA-16-160","3R01HL136734-02S1","NHLBI:159060\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","PORTLAND","UNITED STATES","NEUROSCIENCES","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","Project Narrative: Pulmonary surfactant forms a thin film that stabilizes the small air-sacks in the lungs. Breathing with deficient or ineffective surfactant injures the thin barrier that separates alveolar air from capillary blood. By determining the mechanisms by which pulmonary surfactant functions, this research will provide the basis for understanding how that function can be altered, and how inexpensive therapeutic surfactants can be designed.","3169083; ","HALL, STEPHEN B;","LIN, SARA","09/01/2018","05/31/2020","Address; Adsorption; Adult; Affect; Air; Alveolar; alveolar type II cell; Alveolus; Area; base; Biological Assay; Blood capillaries; Breathing; crystallinity; Data; density; Dependence; design; Environmental air flow; Equilibrium; Exhalation; experimental study; Film; Hydrophobicity; Hypoxemia; In Situ; In Vitro; in vivo; Incidence; interfacial; Irrigation; Lipids; Liquid substance; Location; Lung; lung injury; Measurement; Mechanics; Modeling; monolayer; Oryctolagus cuniculus; Oxygen; Patients; Phospholipids; Physiology; predictive modeling; Premature Infant; Process; Proteins; Pulmonary Edema; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactants; Research; Resistance; Respiratory Failure; Roentgen Rays; Side; Sorting - Cell Movement; Structure; Surface; Surface Tension; surfactant; surfactant function; Surfactant therapy; Temperature; Testing; Thinness; Vesicle; X ray diffraction analysis; ","Mechanisms of Pulmonary Surfactant Function","136734","RIBT","Respiratory Integrative Biology and Translational Research Study Section ","","S1","02","103286","55774","159060",""
"9937161","P01","AG","2","N","05/22/2020","04/01/2020","03/31/2021","","P01AG002132","","PAR-18-297","2P01AG002132-39","NIA:388137\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","SAN FRANCISCO","UNITED STATES","","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","","14893380; ","SCHNIER, PAUL ;","","","","Aging; alpha synuclein; Amyloid; Amyloid beta-Protein; base; biophysical analysis; biophysical properties; biophysical techniques; Biophysics; Brain; Cellular biology; Chemicals; Complement; crosslink; Cryoelectron Microscopy; Data; Disease; Ensure; Escherichia coli; experience; Hydroxyl Radical; Image; Immunohistochemistry; In Vitro; in vivo; Label; laser capture microdissection; Lasers; Length; liquid chromatography mass spectrometry; Mass Spectrum Analysis; Measures; Methodology; Methods; Molecular Conformation; Monitor; Mus; Neurofibrillary Tangles; Peptides; Point Mutation; Preparation; Prions; Production; programs; Protein Analysis; Protein Footprinting; Protein Isoforms; Proteins; Proteomics; Reaction; Reagent; Recombinants; Resolution; Senile Plaques; Services; Site; solid state nuclear magnetic resonance; Solvents; Spatial Distribution; Spectroscopy, Fourier Transform Infrared; Structural Models; Structure; Surface Plasmon Resonance; tau aggregation; tau Proteins; Techniques; Technology; TREM2 gene; ","Core B: Proteomics and Biophysics","002132","ZAG1","Special Emphasis Panel ","6192","","39","240456","147681","","388137"
"9957132","R21","MH","5","N","05/19/2020","05/01/2020","04/30/2021","242","R21MH120468","SCHOOLS OF MEDICINE","PA-18-350","5R21MH120468-02","NIMH:190625\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","SALT LAKE CITY","UNITED STATES","NEUROSCIENCES","02","009095365","US","514002","UNIVERSITY OF UTAH","UT","841128930","PROJECT NARRATIVE The proposed studies will deepen our understanding of gene expression at the allele, protein and cellular level in the brain, and uncover novel epigenetic and allele-specific expression effects that are expected to shape the impact of genetic mutations on brain cell development and function. The proposed research is relevant to public health because it could lead to improvements in our ability to evaluate risk for brain disorders and develop novel therapeutic interventions. !","11343206; ","GREGG, CHRIS ;","BEER, REBECCA LYNN","07/01/2019","04/30/2021","Address; Adolescent; Adult; Affect; Age; Alleles; Behavior; Behavioral; Brain; brain cell; Brain Diseases; Brain region; Candidate Disease Gene; Cell Lineage; cell type; Cells; cohort; Data; Development; Developmental Gene; Diagnostic; differential expression; Disease; DNA Repair; DNA Repair Gene; DNA Sequence Alteration; Economic Burden; Embryo; Epigenetic Process; Epitopes; Expression Profiling; Female; Foundations; Future; Gene Expression; Gene Expression Regulation; Generations; Genes; Genetic Risk; Genetic Variation; Genomic Imprinting; Genomics; Genotype; Goals; Heterozygote; Homozygote; Image; improved; in vivo; Individual; International; Knowledge; Lead; Link; Measures; Mental disorders; Mental Health; Modeling; Mosaicism; Mus; mutant; Mutate; Mutation; National Institute of Mental Health; Nature; Neuroglia; Neurologic; Neurons; neuropsychiatric disorder; NMDA receptor A1; novel; novel therapeutic intervention; Patients; Pattern; Phenotype; Play; Population; postnatal; Primates; Process; Proteins; Public Health; Publications; Reporter; Research; Risk; RNA; Role; Shapes; social; Switch Genes; Synapses; synaptic function; Testing; Therapeutic; Time; Weaning; X Inactivation; ","Functions and Mechanisms of Epigenetic Allelic Effects in the Brain","120468","MNG","Molecular Neurogenetics Study Section ","","","02","125000","65625","190625",""
"9927565","UC7","AI","5","N","05/19/2020","05/01/2020","04/30/2021","","UC7AI094660","","RFA-AI-15-009","5UC7AI094660-10","NIAID:2300917\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","GALVESTON","UNITED STATES","","14","800771149","US","578406","UNIVERSITY OF TEXAS MED BR GALVESTON","TX","775555302","National Biocontainment Laboratories Operational Support ensures the availability of maximum containment laboratories for research that will develop the next generation of therapeutics, diagnostics and vaccines for infectious diseases that can pose a public health risk. It also ensures that high containment labs are available in the event of a public health or bioterrorism emergency. This support is essential due to the high cost of building and maintaining laboratories that protect researchers, ensure the biosecurity of dangerous pathogens, and safeguard the communities where these laboratories are located.","10363552; ","LEDUC, JAMES W.;","","","","biodefense; biosecurity; Bioterrorism; Communicable Diseases; Communities; Containment; cost; Dangerousness; Devices; Diagnostic; Emergency Situation; Ensure; Environmental Health; Equipment; Event; Funding; Goals; Human Resources; Infrastructure; Laboratories; laboratory facility; Laboratory Research; Maintenance; Medical; member; National Institute of Allergy and Infectious Disease; New Mexico; novel therapeutics; Occupations; operation; pathogen; pre-clinical; Preventive; programs; Public Health; public health emergency; Regulation; Research; research facility; Research Personnel; Resources; response; Risk; Schedule; Secure; Security; Services; Testing; Texas; Training; Universities; Vaccines; ","Biosecurity Core - Galveston National Laboratory BSL4 Operations","094660","ZAI1","Special Emphasis Panel ","8721","","10","1490559","810358","","2300917"
"10167302","U19","AI","3","N","05/19/2020","05/19/2020","07/31/2020","","U19AI128913","","PA-18-591","3U19AI128913-03S2","NIAID:55710\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","","1867400 (contact); 7748143; ","REED, ELAINE F (contact); SARWAL, MINNIE M;","ROBIEN, MARK ANDREW","05/19/2020","07/31/2021","","Core-002","128913","","","9129","S2","03","35712","19998","","55710"
"9906239","P01","GM","5","N","05/22/2020","04/01/2020","03/31/2021","","P01GM095467","","PAR-13-280","5P01GM095467-10","NIGMS:317013\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","BOSTON","UNITED STATES","","07","030811269","US","1080401","BRIGHAM AND WOMEN'S HOSPITAL","MA","021156110","","8656605; ","SPITE, MATTHEW R;","","","","3-Dimensional; Acute; Anabolism; Anti-inflammatory; Apoptotic; Bacterial Infections; Cells; Chronic Disease; Clinical; Collaborations; combat; Containment; Coupled; Cutaneous; Development; Environment; Epithelial; Epithelium; Essential Fatty Acids; Excision; Exudate; Failure; Family; Fibrosis; Genetic; Host Defense; Human; Immune; indexing; Infection; infection risk; Inflammation; Inflammatory; Inflammatory Response; injured; Injury; injury and repair; keratinocyte; keratinocyte differentiation; Knowledge; Lead; Link; lipid mediator; macrophage; Mediating; Mediator of activation protein; member; microbial; migration; Molecular; mouse model; Mus; Necrosis; neutrophil; novel therapeutic intervention; novel therapeutics; Operative Surgical Procedures; Pain; pathogen; Pathway interactions; Phagocytosis; Pharmacology; Phase; Play; prevent; Process; programs; receptor; repaired; Resolution; response; Role; Series; Signal Transduction; Skin; skin barrier; Staphylococcus aureus; Structure-Activity Relationship; Surgical Injuries; Testing; Therapeutic; tissue regeneration; tissue repair; Tissues; trauma exposure; ","Project 3: Resolution of Surgical Injury","095467","ZGM1","Special Emphasis Panel ","6583","","10","196547","120466","","317013"
"9868867","P01","AG","5","N","05/18/2020","03/01/2020","02/28/2021","","P01AG009524","","PAR-13-258","5P01AG009524-25","NIA:381293\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON AGING","","TAMPA","UNITED STATES","","14","069687242","US","513807","UNIVERSITY OF SOUTH FLORIDA","FL","336172008","Project 1 NARRATIVE The goal of this project is to identify and understand methods for slowing, halting, or reversing the causes and symptoms of age-related hearing loss (presbycusis). Using separate methods, we will evaluate potential for a hormone intervention to improve inner ear and central auditory function and we will use hearing instruments to induce neural plasticity to and to target hallmark deficits of presbycusis and identify age-related differences in susceptibility to central auditory plasticity.","9489678; ","EDDINS, DAVID A.;","","","","Acoustics; Address; Adult; Age; age related; aged; Aging; aging auditory system; Aldosterone; American; attenuation; Audiology; Auditory; auditory processing; Auditory system; base; Behavioral; Biological Assay; Brain Stem; catalyst; Chronic; clinical practice; cognitive function; Communication; comparative; Complex; design; Elderly; Electrophysiology (science); Environment; Equilibrium; Evaluation; experience; Frequencies; Goals; Growth; Health; Hearing; hearing impairment; Hormone use; Hormones; Human; improved; indexing; innovation; instrument; Intervention; knowledge base; Labyrinth; longitudinal design; Loudness; Measures; Mediating; Methods; Modeling; Molecular; Monitor; Mus; Nature; neural circuit; Neuronal Plasticity; neurophysiology; noise perception; Normal Range; Peripheral; Pharmacological Treatment; Physiological; Population; Potassium Channel; pre-clinical research; Predisposition; Presbycusis; Psychoacoustics; Regulation; relating to nervous system; Research; Research Proposals; Role; Safety; Sampling; Series; Serum; Social Well-Being; sound; speech in noise; Speech Intelligibility; Speech Perception; Stria Vascularis; Supplementation; Support System; Symptoms; targeted treatment; Technology; Testing; Therapeutic; Therapeutic Intervention; Therapeutic Uses; Time; Translations; Treatment Efficacy; United States National Institutes of Health; Variant; Work; ","Project 1 - Research Audiology, Speech Perception, and Psychoacoustics","009524","ZAG1","Special Emphasis Panel ","5993","","25","258665","122628","","381293"
"10102305","P30","CA","3","N","05/21/2020","05/15/2020","11/30/2020","397","P30CA023108","SCHOOLS OF MEDICINE","PAR-17-095","3P30CA023108-41S2","NCI:83332\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","HANOVER","UNITED STATES","PEDIATRICS","02","041027822","US","2021601","DARTMOUTH COLLEGE","NH","037551421","Project Narrative Among the fifty states, New Hampshire ranks number one in the incidence of breast, esophageal, and urinary bladder cancers, the latter reflecting the association between bladder cancer and environmental arsenic exposure linked to frequent use of rural well water within the ?Granite State?. Of similar concern, Vermont ranks number one in the incidence of uterine cancer and second in the incidence of melanoma. Norris Cotton Cancer Center continues to create important new knowledge, engage our community, and influence public policy related to these and other cancers in a manner directly relevant to these unique catchment area public health needs.","1899930; ","LEACH, STEVEN D;","BELIN, PRECILLA L","08/04/1997","11/30/2024","Adopted; anticancer research; Area; Arsenic; Authorship; Biological; Breast; Cancer Biology; cancer care; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Immunology Science; cancer immunotherapy; cancer prevention; career; Caring; Catchment Area; Characteristics; Clinic; Clinical; Clinical Trials; college; Communities; Community Outreach; Continuity of Patient Care; design; Development; Education; Education and Outreach; Engineering; Entrepreneurship; Esophagus; Evaluation; experience; Faculty Recruitment; faculty research; Frequencies; Funding; Genomics; granite; Growth; health care delivery; health equity; Health Promotion; Health system; Immunology; Immunooncology; Incidence; innovation; Institution; interdisciplinary collaboration; Investigational Therapies; investigator-initiated trial; Investments; Knowledge; Lead; Leadership; Link; Malignant neoplasm of urinary bladder; Malignant Neoplasms; Medical; medical schools; melanoma; member; Mission; Molecular Epidemiology; New Hampshire; Norris Cotton Cancer Center; novel; Parents; Pathology; Patients; Phase; Population; Population Heterogeneity; Population Sciences; precision oncology; prevent; Prevention; programs; Public Health; Public Policy; Publications; Research; Research Infrastructure; Research Support; Research Training; Resource Sharing; Rural; Rural Population; Schools; Science; Site; Strategic Planning; survivorship; Therapeutic; Trace Elements; Translating; Translational Research; United States National Institutes of Health; Update; Uterine Cancer; Vermont; well water; ","Cancer Center Support Grant","023108","NCI","Subcommittee I - Transistion to Independence ","","S2","41","50812","32520","83332",""
"10040304","R21","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R21AI153769","","PA-19-053","1R21AI153769-01","NIAID:212500\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","PROJECT NARRATIVE The proposed research will significantly improve our understanding of the function of a nonstructural protein that is found in the genome of several species of rotavirus, an important cause of diarrheal disease. This work will inform us about the capacity of different rotavirus species and strains to infect specific human and animal hosts and to spread between cells within an infected host. Such information will help us to better predict or prevent future diarrheal disease epidemics caused by relevant rotavirus species.","14284564; ","OGDEN, KRISTEN ;","ALARCON, RODOLFO M","05/21/2020","04/30/2022","Adult; Affect; age group; Animals; Architecture; Biological; Biological Process; Biology; C-terminal; Cell fusion; Cells; Cessation of life; Child; Coupled; Cultured Cells; Detection; Diarrhea; diarrheal disease; Disease; Double Stranded RNA Virus; Engineering; Epidemic; Epidemiology; experimental study; Family; Family suidae; fetal bovine serum; Future; Genes; genetic manipulation; genetic technology; Genome; Giant Cells; Human; improved; In Vitro; Infant; Infection; insight; Integral Membrane Protein; Intestines; Knowledge; live cell imaging; Mediating; Methods; Modeling; Molecular; Molecular Virology; N-terminal; Nonstructural Protein; Open Reading Frames; Orthoreoviruses; Pathogenesis; Pathway interactions; Population; prevent; Primates; protein function; protein structure function; Proteins; Publishing; Reovirus; Reporter; Reporting; Research; reverse genetics; Rodent; Rotavirus; SH2D3A gene; Source; Species Specificity; Specificity; System; Testing; tissue culture; transmission process; Tropism; Viral; Viral Nonstructural Proteins; Viral Pathogenesis; Virulence; Virus; Virus Diseases; Virus Replication; Work; Zoonoses; ","Rotavirus species B NSP1-1 contributions to tropism and spread","153769","VIRB","Virology - B Study Section ","","","01","125000","87500","212500",""
"9920114","R25","DA","5","N","05/18/2020","05/01/2020","04/30/2021","279","R25DA037756","","PAR-18-083","5R25DA037756-07","NIDA:371402\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","VANCOUVER","CANADA","","","251949962","CA","957601","UNIVERSITY OF BRITISH COLUMBIA","BC","V6T 1Z3","PROJECT NARRATIVE The enormous burden of disease related to drug and alcohol addiction remains a global public health challenge. In particular, the lack of clinician researchers in addiction medicine creates major barriers to developing and implementing evidence-based prevention and treatment modalities for substance use disorders. In response, we have created a NIDA-funded addiction research training fellowship for addiction medicine clinicians to develop the skills required for a career in addiction research, and we are proposing the renewal of this program in light of its success to date.","14492644; ","FAIRBAIRN, NADIA ;","WILEY, TISHA R A","04/01/2014","04/30/2024","Academic Training; addiction; Address; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Area; base; British Columbia; burden of illness; Canada; care providers; care systems; career; career development; Caring; Clinical; clinical care; clinical development; Clinical Research; Clinical Trials; comorbidity; Complement; design; Development; Discipline of Nursing; Disease Outbreaks; Diverse Workforce; Drug Addiction; Drug usage; Drug user; education research; Educational Activities; educational atmosphere; Environment; Ethics; Evaluation; evidence base; Evidence based treatment; experience; Faculty; Feedback; Fellowship; Fellowship Program; Fentanyl; flexibility; Funding; Goals; Grant; hands on research; Health; HIV; implementation science; improved; innovation; interest; International; Intervention; Light; Link; Measures; Medicine; Mentors; Mentorship; Methods; Modality; multidisciplinary; National Institute of Drug Abuse; next generation; North America; Nurses; opioid epidemic; opioid mortality; opioid overdose; Outcome; Output; Physicians; Prevention; Productivity; programs; prospective; Public Health; Publications; recruit; Request for Applications; Research; research and development; Research Infrastructure; Research Methodology; Research Peer Review; Research Personnel; research study; Research Training; Resources; response; Role; scale up; Science; Scientist; skill acquisition; skills; skills training; Social Work; Social Workers; Substance Use Disorder; success; Systems Development; Training; Training and Education; Training Programs; Universities; Vocational Guidance; Work; ","Mentoring the next generation of addiction clinician scientists while responding to the opioid epidemic","037756","ZDA1","Special Emphasis Panel ","","","07","349712","21690","371402",""
"10043487","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI154471","","PA-19-053","1R21AI154471-01","NIAID:266250\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LA JOLLA","UNITED STATES","","49","781613492","US","7375802","SCRIPPS RESEARCH INSTITUTE","CA","920371000","Project Narrative: Renal ischemia/reperfusion injury (IRI) is often unavoidable in hospitalized patients and mechanistic evaluations are urgently needed in order to develop preventive and therapeutic strategies. The PI?s laboratory has found that the intracellular pattern recognition receptor AIM2 plays a role as a natural regulator of injury to the kidney following experimental reduction of blood flow. The proposed project examines the mechanisms by which this novel molecular target regulates hypoxic kidney injury.","1899528; ","MCKAY, DIANNE B;","KEHN, PATRICIA J","05/22/2020","04/30/2022","Acute Renal Failure with Renal Papillary Necrosis; Address; AIM2 gene; animal facility; Apoptosis; biological adaptation to stress; Blood flow; Caspase; Cell Death; cell injury; cell type; Cells; Cellular Stress; Chronic Kidney Failure; Clinical; clinical development; clinically relevant; Complex; cytokine; Data; Development; DNA; Elements; Epithelial Cells; Evaluation; Event; experimental study; Functional disorder; Genetic; Genetic Transcription; Goals; Harvest; Health; Human; human model; Hypoxia; IL18 gene; Immunologic Receptors; in vivo; Inflammasome; Inflammation; Inflammation Mediators; Inflammatory; injured; Injury; Injury to Kidney; Innate Immune System; Institution; Interferons; Kidney; Kidney Transplantation; Knowledge; Laboratories; Learning; man; Mediating; Mediator of activation protein; meetings; Molecular Target; Mus; novel; Operative Surgical Procedures; Oxidative Stress; pathogen; Pathogenicity; Patients; Pattern recognition receptor; Play; prevent; Prevention therapy; Preventive; Process; Proteins; recruit; Regulation; renal hypoxia; renal ischemia; Reperfusion Injury; Research; response; response to injury; Rodent Model; Role; targeted treatment; Testing; Therapeutic; tissue injury; TLR2 gene; transplant model; Transplantation; Treatment Efficacy; Tubular formation; Up-Regulation; Work; ","AIM2 as a negative regulator of renal ischemia/reperfusion injury","154471","PBKD","Pathobiology of Kidney Disease Study Section ","","","01","150000","116250","266250",""
"10010924","R43","HG","1","N","05/22/2020","05/22/2020","04/30/2021","172","R43HG011215","","PA-19-272","1R43HG011215-01","NHGRI:350000\","SBIR-STTR RPGs","2020","NATIONAL HUMAN GENOME RESEARCH INSTITUTE","","PHILADELPHIA","UNITED STATES","","03","080687479","US","10046739","GOEPPERT, LLC","PA","191031343","Narrative The proposal addresses key obstacles that must be overcome to achieve enzyme-less nanopore- based low-cost high-speed sequencing of chromosomal length DNA molecules. This project will help improve the quality and efficiency of DNA sequencing and enable direct RNA sequencing (e.g., longer read lengths, faster turn-around time, greater accuracy, and higher-throughput etc.) at reasonable costs with the anticipation that significant advances in any of these and related areas would make significant contributions to the mission of NHGRI and the field of genomics, including to many of NHGRI's other technology development goals.","12298765; ","NIEDZWIECKI, DAVID JOHN;","SMITH, MICHAEL","05/22/2020","04/30/2021","Ablation; Address; Amplifiers; Area; base; Buffers; Caliber; Complex; cost; Coupled; Custom; Detection; Development; Devices; Dimensions; DNA; DNA sequencing; Electrodes; Electrolytes; Electronics; Elements; Entropy; Enzymes; Event; feeding; fluorophore; Freedom; Genomics; Goals; Image; improved; Ions; Label; Length; Measurement; Measures; Membrane; Methods; Microfluidics; Mission; Molecular Conformation; Monitor; Motion; nanochannel; nanoimprint lithography; nanopore; National Human Genome Research Institute; new technology; Noise; novel; operation; Optics; Output; Performance; Phase; Photons; Polymerase; R43 grant; Running; sensor; sequencing platform; Ships; Signal Transduction; silicon nitride; single molecule; Single-Stranded DNA; Small Business Innovation Research Grant; solid state; Speed; Stochastic Processes; Structure; System; Techniques; Technology; technology development; Temperature; temporal measurement; Thinness; Time; transcriptome sequencing; United States National Institutes of Health; Variant; voltage; ","Nanochannel-nanopore based DNA sequencing with DNA motion control and reduced entropic noise","011215","ZRG1","Special Emphasis Panel ","","","01","","","350000",""
"9904745","R01","GM","5","N","05/20/2020","04/01/2020","03/31/2021","859","R01GM123193","SCHOOLS OF MEDICINE","PA-16-160","5R01GM123193-05","NIGMS:331866\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MADISON","UNITED STATES","INTERNAL MEDICINE/MEDICINE","02","161202122","US","578503","UNIVERSITY OF WISCONSIN-MADISON","WI","537151218","PROJECT NARRATIVE Sepsis, defined as life-threatening organ dysfunction in response to infection, is a devastating condition that contributes to up to half of hospital deaths and over $24 billion in costs in the US. The purpose of this project is to use data from the electronic health record and statistical modeling techniques to identify high-risk infected patients and determine which subgroups of patients benefit most from early and more aggressive interventions. This work will result in novel algorithms to identify high-risk infected patients that can be implemented in the electronic health record to decrease preventable death.","10739456; ","CHURPEK, MATTHEW MICHAEL;","DUNSMORE, SARAH","05/01/2017","03/31/2022","Address; Advisory Committees; Algorithm Design; Algorithms; Anti-inflammatory; Area; base; Caregivers; Caring; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Clinical; clinical phenotype; Cluster Analysis; cohort; Complex; cost; Critical Care; Critical Illness; Data; Data Set; Detection; Deterioration; Diagnosis; disability; Early Diagnosis; Early identification; Early Intervention; Early treatment; electronic data; Electronic Health Record; Functional disorder; Future; Goals; Grant; Health Care Costs; Heart Arrest; high risk; Home environment; Hospitals; Immune response; Impaired cognition; improved; improved outcome; Infection; Infectious Agent; Inpatients; Intensive Care Units; Intervention; Intervention Trial; Intuition; Knowledge; Label; Lead; learning strategy; Life; Lighting; Logistic Regressions; Machine Learning; machine learning algorithm; Manuals; Medicine; Methods; Modeling; Modernization; mortality; novel; Organ; Outcome; Patient risk; patient subsets; Patients; personalized care; Pharmaceutical Preparations; preventable death; Probability; Publishing; random forest; Research; Resources; response; Risk; Risk Factors; Risk stratification; Savings; Sepsis; septic patients; Severity of illness; side effect; Statistical Models; Subgroup; Survivors; Syndrome; Techniques; Time; tool; Validation; Variant; ward; Work; ","Sepsis Early Prediction and Subphenotype Illumination  Study (SEPSIS)","123193","BCHI","Biomedical Computing and Health Informatics Study Section ","","","05","256100","75766","331866",""
"10142683","P01","AI","3","N","05/18/2020","05/18/2020","06/30/2020","855","P01AI091580","SCHOOLS OF MEDICINE","PA-18-591","3P01AI091580-09S1","NIAID:107532\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","SAN FRANCISCO","UNITED STATES","INTERNAL MEDICINE/MEDICINE","12","094878337","US","577508","UNIVERSITY OF CALIFORNIA, SAN FRANCISCO","CA","941186215","PROJECT NARRATIVE The SARS coronavirus-2 (SARS-CoV-2) rapid emergence has led to a critical pandemic of coronavirus disease (COVID-19) with over 1.4M cases worldwide, creating an urgent need to understand the immunopathology of COVID-19 and study the interactions of the lung epithelium with the immune system. The goal of this Administrative Supplement is to characterize the lung epithelial response to infection by different sub-strains of SARS-CoV-2 and to obtain a comprehensive overview of T cell activation and T cell signaling in the context of SARS-CoV-2 versus H1N1 influenza infection of Airway Organoids. The proposed research will provide a resource ?Airway Organoid Biobank? with detailed single cell RNAseq- and CyTOF- characterization of SARS-CoV-2- versus H1N1pdm- infection and obtain mechanistic insights into CD4+ and CD8+ T cell responses to SARS-CoV-2, needs that are indicated in NOT-AI-20-31.","1881581; ","WEISS, ARTHUR ;","MALLIA, CONRAD M","05/18/2020","06/30/2021","2019-nCoV; adaptive immunity; Address; Administrative Supplement; Adult Respiratory Distress Syndrome; Autoimmune Diseases; biobank; Biochemistry; Biological Assay; Biology; biosafety level 3 facility; Cancer Patient; Carcinoma; CD27 Antigens; CD4 Positive T Lymphocytes; CD8-Positive T-Lymphocytes; CD8B1 gene; Cell Communication; Cell Culture Techniques; Cells; Cellular biology; Clinical; Collection; Communities; Complex; computerized data processing; Containment; Coronavirus; COVID-19; cytotoxic; Data Science; Data Set; Development; Disease; Epithelial; Epithelial Cells; Epithelium; Evaluation; Gene Expression; Generations; Genomics; Goals; high resolution imaging; Human; Immune; immune function; Immune response; Immune system; Immunologics; immunopathology; improved; Infection; Inflammation; Influenza; Influenza A Virus, H1N1 Subtype; influenzavirus; insight; Interferons; Intervention; Investigational Therapies; Knowledge; Letters; Libraries; Link; Lung; Lung infections; Maps; Non-Small-Cell Lung Carcinoma; novel therapeutic intervention; Organoids; pandemic disease; Parents; Pathogenesis; Pathologic; Patients; Play; Production; programs; Reagent; Research; Resources; response; Role; sample fixation; Signal Transduction; Specialist; Stains; T cell response; T Virus; T-Cell Activation; T-Lymphocyte; Technology; Testing; Tissues; transcriptome sequencing; transmission process; Viral; Virus; Virus Diseases; Work; ","Understanding T cell responses and T cell signaling in human airway organoids with SARS-CoV-2 infection","091580","","","","S1","09","66998","40534","107532",""
"9898479","R13","NS","5","N","05/20/2020","04/01/2020","03/31/2021","853","R13NS040925","","PA-13-347","5R13NS040925-24","NINDS:35000\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE","","MORRISTOWN","UNITED STATES","","11","962464756","US","3145202","ATLANTIC HEALTH SYSTEM, INC.","NJ","079606459","PUBLIC HEALTH RELEVANCE: This application describes our plan for the continuation of symposia titled, Neurobiology of Disease in Children (NDC), to be held in conjunction with the 2016 to 2020 annual Child Neurology Society (CNS) meetings. In 2016 - 2020 symposium topics will include: neurofibromatosis - type I and II, leukodystrophies, brain tumors, Tourette syndrome, and traumatic brain injury; clinical conditions that practicing child neurologists encounter on a weekly basis. Moving forward, we plan to stay true to the established role of the NDC in the field of child neurology; which is to say, we plan to bring together clinicians, scientists, caregivers and NIH program officers to determine how recent findings in child neurology can be translated to enhance clinical understanding and affect clinical practice.","3152037; ","MARIA, BERNARD L;","VIVALDA, JOANNA","04/15/2001","03/31/2021","Address; Advisory Committees; Affect; Area; autism spectrum disorder; Awareness; base; Brain Neoplasms; Caregivers; Caring; Child; Childhood; Clinical; Clinical Management; clinical practice; Clinical Research; Communities; Country; Development; Diagnostic; Discipline; Disease; Ensure; Event; Evolution; Feedback; Future; Gilles de la Tourette syndrome; improved; interdisciplinary collaboration; interest; Learning; lectures; leukodystrophy; Light; Medicine; meetings; nervous system disorder; Neurobiology; Neurofibromatosis 1; Neurologic; Neurologic Dysfunctions; Neurologist; Neurosciences; NIH Program Announcements; Pathogenesis; Pediatric Hospitals; Pediatric Neurology; programs; public health relevance; Request for Proposals; Research; Research Personnel; response; Role; Scientist; Societies; success; symposium; therapeutic target; tool; training opportunity; Translating; Traumatic Brain Injury; treatment strategy; United States National Institutes of Health; ","Neurobiology of Disease in Children Conferences","040925","NSD","National Institute of Neurological Disorders and Stroke Initial Review Group ","","","24","35000","","35000",""
"9079205","I01","VA","1","N","05/19/2020","10/01/2016","09/30/2017","999","I01HX001790","","RFA-HX-15-026","1I01HX001790-01A2","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","PALO ALTO","UNITED STATES","","18","046017455","US","481014","VETERANS ADMIN PALO ALTO HEALTH CARE SYS","CA","943041207","Posttraumatic Stress Disorder (PTSD) is an often severe and frequently disabling condition. It is associated with compromised health, early mortality, and substantial economic costs. PTSD is common in VA primary care patients; however, brief, effective treatments for PTSD are not available in the primary care setting. Instead, patients with PTSD are referred to mental health settings, yet many patients do not accept these referrals or do not adequately engage in such services. Thus, this project seeks to improve health care for Veterans by testing the effectiveness of a primary care-based treatment called clinician-supported PTSD Coach. In this treatment a primary care mental health clinician guides patients in using the PTSD Coach mobile app to learn about PTSD symptoms, treatment options, and strategies to cope with common PTSD- related concerns. If this treatment is found to be effective at reducing PTSD symptoms and increasing use of mental health care, it will provide a tremendous benefit to Veterans with PTSD seen in VA primary care.","9963390 (contact); 10362837; ","KUHN, ERIC ROLAND (contact); POSSEMATO, KYLE ;","","10/01/2016","09/30/2020","Address; Aftercare; arm; Assessment tool; base; Brief Psychotherapy; Caring; Cellular Phone; Clinical; Clinical Practice Guideline; clinically significant; comorbidity; coping; Coping Skills; Data; economic cost; Education; Educational process of instructing; effective therapy; Effectiveness; Emotional; evidence base; Feedback; follow-up; Fright; functional disability; functional status; Goals; Health; health care quality; health care settings; Health Personnel; Healthcare; improved; improved outcome; innovation; innovative technologies; Instruction; Intervention; Interview; Learning; Link; Measures; Mediator of activation protein; Medical; medical specialties; Mental Health; Mental Health Services; Methodology; mHealth; mobile application; mobile computing; Modeling; Monitor; mortality; Outcome; Participant; Patient Care; patient oriented; Patient Self-Report; Patients; Persons; Pharmaceutical Preparations; Post-Traumatic Stress Disorders; primary care setting; Primary Health Care; programs; Provider; psychiatric symptom; psychoeducation; psychoeducational; Psychotherapy; racial and ethnic; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Reading; reduce symptoms; Reporting; Research; Research Design; Research Methodology; Resources; satisfaction; Self Efficacy; Self Management; self-management program; Services; Severities; shared decision making; Site; Social support; socioeconomics; Stigmatization; stress related disorder; symptom treatment; Symptoms; Technology; Telephone; Testing; Time; treatment as usual; treatment center; Veterans; Visit; ","An RCT of a Primary Care-based PTSD Intervention: Clinician-Supported PTSD Coach","001790","HSR4","HSR-4  Mental and Behavioral Health ","","A2","01","","","",""
"10071557","R21","AI","1","N","05/21/2020","05/21/2020","04/30/2021","855","R21AI149112","SCHOOLS OF MEDICINE","PA-19-237","1R21AI149112-01A1","NIAID:234095\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","DURHAM","UNITED STATES","BIOCHEMISTRY","01","044387793","US","2221101","DUKE UNIVERSITY","NC","277054673","Project Narrative The recent global outbreak of Zika virus infection resulted in several severe complications, in- cluding fetal microcephaly, Guillain-Barre syndrome, and other devastating neurological disorders. As there are currently no effective therapies for Zika virus, its reemergence could pose an imminent threat to global public health. The proposed study will generate small mole- cule leads that inhibit the replication of the Zika virus by binding and stabilizing inactive conformations of an essential non-coding RNA to ultimately limit Zika infection and associated disease.","8134386 (contact); 9385288; ","AL-HASHIMI, HASHIM M (contact); HORNER, STACY MICHELLE;","DAVIS, MINDY I","05/21/2020","04/30/2022","3' Untranslated Regions; Address; Adopted; Antiviral Agents; Antiviral Response; Antiviral Therapy; base; Binding; Binding Sites; Biological Assay; Cell Line; cell type; Cells; Complex; Crystallization; Data; Dengue Virus; Development; Disease; Disease Outbreaks; Docking; drug discovery; Drug Targeting; effective therapy; Elements; Epidemic; Exonuclease; Family; fetal; Flaviviridae; Flavivirus; Foundations; Genome; Goals; Guillain-Barré Syndrome; helicase; high throughput screening; human pathogen; Hybrids; Hydrophobicity; in silico; In Vitro; in vitro Assay; Infection; inhibitor/antagonist; insight; Laboratories; Libraries; Ligand Binding; Ligands; Link; Mediating; Microcephaly; Molecular Conformation; mosquito-borne; Mutation; nervous system disorder; NMR Spectroscopy; novel; Nuclear Magnetic Resonance; Nucleotides; Pathogenesis; Pathogenicity; Pathologic; Pathology; Pathway interactions; Positioning Attribute; Production; Proteins; Public Health; Resistance; Risk; RNA; RNA Decay; RNA Viruses; scaffold; screening; Series; small molecule; Small RNA; spleen exonuclease; Structure; Technology; Testing; Therapeutic; therapeutic development; three dimensional structure; Toxic effect; Translating; Untranslated Regions; Untranslated RNA; Viral; Viral Genome; viral RNA; virology; virtual; virtual library; virtual screening; Virulence; Virus; Virus Replication; West Nile virus; Work; Yellow fever virus; Zika Virus; ZIKV infection; ","Targeting Regulatory RNA elements in the Zika Virus","149112","ZRG1","Special Emphasis Panel ","","A1","01","150000","84095","234095",""
"9920187","R01","HL","5","N","05/21/2020","05/01/2020","04/30/2021","838","R01HL121228","","PA-18-345","5R01HL121228-06","NHLBI:775239\","Non-SBIR/STTR RPGs","2020","NATIONAL HEART, LUNG, AND BLOOD INSTITUTE","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","PUBLIC HEALTH RELEVANCE / NARRATIVE Mechanical ventilation is a life support method used in intensive care and surgical patients, which can paradoxically injure the lungs. We will use novel lung imaging techniques to optimize the delivery of mechanical ventilation to patients without severe lung disease and to generate fundamental knowledge on regional lung vascular damage in the early stages of lung injury. The results are expected to improve pulmonary outcomes of a large fraction of the ~17 million US surgical patients/year receiving general anesthesia and of mechanically ventilated critical care patients, and to provide new understanding on ventilator associated mechanisms of vascular injury.","8034968; ","VIDAL MELO, MARCOS F;","REINECK, LORA A","01/01/2014","04/30/2024","Adult Respiratory Distress Syndrome; Animals; Automobile Driving; base; Biological Markers; Blood capillaries; Blood flow; Blood Vessels; Blood Volume; Carbon Monoxide; Clinical; Clinical Research; clinically relevant; Critical Care; Data; Deterioration; early detection biomarkers; Emission-Computed Tomography; Endothelium; Endotoxemia; Environmental air flow; experimental study; Exposure to; Gene Expression; General Anesthesia; Glucose; glucose uptake; Goals; Heterogeneity; Human; Image; image guided; imaging biomarker; imaging modality; Imaging Techniques; improved; Individual; Inflammation; Inflammation Mediators; Inflammatory; Injury; Intensive Care; Interruption; Intubation; Knowledge; Length; Life; Literature; Lung; Lung diseases; lung imaging; Lung Inflammation; lung injury; Measures; Mechanical ventilation; Mechanics; Methods; Modeling; Morbidity - disease rate; mortality; neutrophil; novel; Operative Surgical Procedures; Outcome; Patient Care; Patients; Pattern; Periodicity; personalized strategies; Positive-Pressure Respiration; Positron-Emission Tomography; pressure; prevent; Prevention; Process; public health relevance; Reporting; Resolution; respiratory; Respiratory Mechanics; Respiratory System; Risk; septic patients; Sheep; Spatial Distribution; Stretching; Suggestion; Supination; Testing; Tissue Sample; vascular injury; Ventilator; Ventilator-induced lung injury; X-Ray Computed Tomography; ","PET/CT-Guided Personalized Mechanical Ventilation to Minimize Ventilator-Induced Lung Injury","121228","MEDI","Medical Imaging Study Section ","","","06","472087","303152","775239",""
"9921196","R01","AR","5","N","05/18/2020","05/01/2020","04/30/2021","846","R01AR066028","SCHOOLS OF MEDICINE","PA-13-302","5R01AR066028-06","NIAMS:514612\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES","","ANN ARBOR","UNITED STATES","ORTHOPEDICS","12","073133571","US","1506502","UNIVERSITY OF MICHIGAN AT ANN ARBOR","MI","481091276","PUBLIC HEALTH RELEVANCE: Compromised bone fracture healing resulting in non-union and delayed union is a highly-significant clinical problem. A primary factor resulting in compromised fracture healing is lack of proper blood flow, also known as ischemia. We propose that if we can increase blood flow under ischemic conditions, then we can improve fracture healing outcome. Our work will demonstrate the key role of thrombospondin signaling with CD47 in regulating ischemic fracture healing and will disrupt this ligand-receptor interaction to increase healing in an ischemic mouse model.","1858864; ","HANKENSON, KURT DAVID;","CHEN, FAYE H","09/15/2015","04/30/2021","Address; Adenoviruses; Affect; Affinity; angiogenesis; Angiogenesis Inhibitors; Angiogenic Factor; Anti-CD47; Antibodies; Back; base; Binding; Blood flow; Blood Vessels; bone; Bone callus; bone healing; Bone Regeneration; CD47 gene; Cells; Clinical; cost; Exhibits; experimental study; Extracellular Matrix Proteins; Family member; Foundations; Fracture; Fracture Healing; gain of function; healing; Human; Hypoxia Inducible Factor; improved; inhibitor/antagonist; Injury; Ischemia; ischemic injury; keratinocyte growth factor; Kidney; Knockout Mice; Ligands; Liver; loss of function; Mesenchymal; Mesenchyme; Metabolic; Methodology; mineralization; mouse model; Mus; Muscle; Natural regeneration; non-healing wounds; nutrition; Operative Surgical Procedures; Osteogenesis; Outcome; overexpression; Pain; Patients; Peptides; Phase; Pre-Clinical Model; preclinical study; Production; public health relevance; receptor; Recovery; repaired; Reperfusion Therapy; response; Risk Factors; Role; Signal Transduction; Site; Skin; Societies; Specificity; Testing; Therapeutic; Thrombospondin 1; thrombospondin 2; Thrombospondins; Tissues; Transduction Gene; Vascular Endothelial Growth Factors; Vascularization; Work; ","Regulators of Ischemic Fracture Healing","066028","SBSR","Skeletal Biology Structure and Regeneration Study Section ","","","06","402672","111940","514612",""
"9922351","K01","MH","5","N","05/20/2020","05/01/2020","04/30/2021","242","K01MH111388","SCHOOLS OF PUBLIC HEALTH","PA-14-044","5K01MH111388-04","NIMH:129302\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","BALTIMORE","UNITED STATES","PUBLIC HEALTH & PREV MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Project Narrative Retention in HIV care is important for the health of people living with HIV as well as for reduction of HIV transmissions. Black men who have sex with men are one of the populations most disproportionately burdened by HIV. This project will develop a HIV retention in care program for BMSM that includes a job readiness component and provide training to the recipient in implementation science, intervention development, and experimental design.","9287920; ","MAULSBY, CATHERINE HADELER;","STIRRATT, MICHAEL J","05/05/2017","04/30/2021","Address; AIDS prevention; AIDS/HIV problem; antiretroviral therapy; Area; Baltimore; base; Behavioral; black men who have sex with men; care providers; career; career preparation; Caring; Case Management; Clinic; Clinic Visits; Continuity of Patient Care; Counseling; Data; Discrimination; disparity reduction; Educational Curriculum; effective intervention; Effectiveness; Employment Status; empowered; evidence base; Experimental Designs; experimental study; Focus Groups; Goals; Health; HIV; HIV diagnosis; HIV Infections; implementation research; implementation science; Imprisonment; Incidence; interest; Intervention; Interview; K-Series Research Career Programs; Medical; men; men who have sex with men; Methods; Minority; Modeling; novel; Observational Study; Outcome; outreach; Patients; peer; Population; Poverty; practice setting; Prevalence; Prevention program; primary outcome; Program Development; Program Evaluation; programs; Provider; Race; Research; Research Design; Research Training; Risk; Self Determination; Services; sex; Sex Orientation; skills; Social Marketing; social stigma; Social support; Social Work; Structure; Testing; theories; therapy development; Training; translational scientist; transmission process; treatment disparity; Treatment outcome; Underserved Population; Unemployment; United States National Institutes of Health; Viral; Work; ","An HIV Retention in Care Intervention for Black MSM in Baltimore with a Job Readiness Component","111388","ZRG1","Special Emphasis Panel ","","","04","119724","9578","129302",""
"9933895","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:90870\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","8007584; ","WELLS, K. SAM;","","","","Capital; career development; Caring; Cell physiology; cellular imaging; collaborative environment; Confocal Microscopy; Consult; Consultations; cost; Data Analyses; Development; Diabetes Mellitus; digital imaging; Electron Microscopy; Ensure; Equipment; Experimental Designs; experimental study; Fee-for-Service Plans; Fluorescence; Funding; Goals; Grant; Image; Image Analysis; image processing; imaging capabilities; Imaging Techniques; Imaging technology; in vivo; in vivo imaging; Individual; innovation; instrument; intravital imaging; Laboratories; Laser Scanning Microscopy; medical specialties; member; Methodology; microscopic imaging; Microscopy; Modernization; multidisciplinary; Optics; organizational structure; Preparation; prevent; Process; Quality Control; Research; Research Personnel; Research Support; Research Training; Resolution; Resource Sharing; Resources; Scanning Electron Microscopy; Schedule; Services; skills; Specimen; Subcellular Anatomy; Supporting Cell; System; Systems Analysis; technology development; Tissues; Training; Transmission Electron Microscopy; two-photon; Update; web based interface; ","Cell Imaging Shared Resource","020593","ZDK1","Special Emphasis Panel ","7648","","43","86283","4587","","90870"
"9932510","R01","MH","5","N","05/22/2020","03/01/2020","02/28/2021","242","R01MH119264","SCHOOL OF MEDICINE & DENTISTRY","RFA-MH-18-701","5R01MH119264-02","NIMH:665724\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF MENTAL HEALTH","","ROCHESTER","UNITED STATES","PSYCHIATRY","25","041294109","US","7047101","UNIVERSITY OF ROCHESTER","NY","146270140","PROJECT NARRATIVE Effective, brief, low-cost interventions for individuals who attempt suicide are needed to save lives and achieve the goals of the National Strategy for Suicide Prevention. In response to a NIMH Notice of Interest, this time- sensitive proposal leverages an existing federal investment in Zero Suicide to test the effectiveness of a highly promising new treatment for recent suicide attempt survivors and learn how it works. If hypotheses are supported, the study will provide evidence of a brief, practical, and cost-effective therapy that reduces suicide reattempts in a real-world health setting.","9475519; ","PISANI, ANTHONY R;","O'CONNOR, STEPHEN","05/20/2019","02/29/2024","Accounting; Address; American; arm; Award; base; Belief; brief intervention; Caring; Clinical; Clinical Sciences; Communities; cost; cost effective; cost effectiveness; Cost Effectiveness Analysis; cost-effectiveness ratio; Data; design; Distress; effective therapy; Effectiveness; effectiveness research; efficacy trial; Emergency medical service; Emergency Situation; Evaluation; experience; Feeling; Finland; follow-up; Funding; Future; Goals; Grant; group intervention; Health system; Healthcare Systems; hospital utilization; Human Resources; improved; incremental cost-effectiveness; Individual; inpatient service; Inpatients; insight; interest; Intervention; intervention cost; intervention program; Interview; Investigation; Investments; Leadership; Learning; Length of Stay; Loneliness; Mediating; Mediation; Medical Records; Mental Health; Mental Health Services; Modeling; National Institute of Mental Health; New York; novel; novel therapeutics; Participant; Patient Education; patient engagement; Patients; Perception; Persons; program costs; programs; Protocols documentation; Provider; psychologic; Public Sector; Randomized; Randomized Controlled Trials; Recovery; reducing suicide; Reporting; Request for Applications; Research; Research Personnel; Research Support; response; Risk; Safety; Savings; Services; Shame; Statistical Data Interpretation; suicidal; Suicide; Suicide attempt; Suicide prevention; suicide rate; Survivors; Sweden; Switzerland; System; Testing; theories; Therapeutic; Time; Training; treatment arm; treatment as usual; treatment effect; treatment services; United States Substance Abuse and Mental Health Services Administration; Visit; Work; World Health; ","Effectiveness of a Targeted Brief Intervention for Recent Suicide Attempt Survivors","119264","ZMH1","Special Emphasis Panel ","","","02","522026","143698","665724",""
"10007300","R41","AI","1","N","05/20/2020","05/21/2020","04/30/2021","855","R41AI149809","","PA-19-270","1R41AI149809-01A1","NIAID:299999\","SBIR-STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","Raleigh","UNITED STATES","","04","080059821","US","10041645","ARREVUS, INC.","NC","27612","Project Narrative Sepsis is a systemic inflammatory syndrome that is initiated by the presence of an infection and is associated with high mortality. Current therapeutic options do not properly address antibiotic-resistant pathogens and the host inflammatory response. Arrevus is developing a new class of antimicrobial peptides derived from insects that act via a novel mode of action with both antimicrobial and immunomodulatory activities to serve as an effective treatment for sepsis.","14926610; ","KRAUS, CARL ;","XU, ZUOYU","05/21/2020","04/30/2021","adaptive immune response; adaptive immunity; Address; Adjuvant Therapy; Adrenal Cortex Hormones; Agonist; Animals; Antibiotic Resistance; Antibiotic Therapy; Antibiotics; antimicrobial; antimicrobial drug; antimicrobial peptide; Azithromycin; Bacterial Infections; Bacterial Model; Bacterial Proteins; bacterial resistance; Binding; blood product; Catabolism; CD28 gene; CD3 Antigens; cecal ligation puncture; Cessation of life; Chronic; Chronic stress; Colistin; Critical Illness; cytokine; Data; Development; Disease; drug resistant pathogen; Dysplasia; effective therapy; Elderly; Evaluation; Exhibits; Experimental Models; Functional disorder; Goals; Guidelines; Heat shock proteins; Homologous Gene; Hospitals; Human; Imipenem; Immune; Immune response; Immunity; Immunologics; immunoregulation; immunosuppressed; Immunosuppression; improved; in vivo; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; inhibitor/antagonist; Insecta; Interferons; Lead; Life; Liquid substance; Measurement; Measures; Mechanical ventilation; Medical; Membrane Lipids; Modeling; Molecular Chaperones; monocyte; mortality; mouse model; Multi-Drug Resistance; multi-drug resistant pathogen; Multiple Bacterial Drug Resistance; Mus; Natural Immunity; novel; novel strategies; novel therapeutics; organ injury; pathogenic bacteria; Patients; Peripheral; peripheral blood; Peripheral Blood Mononuclear Cell; Peritonitis; Pharmaceutical Preparations; Phase; phase 2 study; Plasma; polymicrobial sepsis; Populations at Risk; Positioning Attribute; pre-clinical; Production; Program Development; programs; Proline; Property; protein folding; Proteins; Recovery; response; Resuscitation; Safety; Sepsis; septic patients; Small Business Technology Transfer Research; Splenocyte; Stress; Supportive care; Survivors; Syndrome; systemic inflammatory response; T-Lymphocyte; Therapeutic; Therapeutic Intervention; TNF gene; Treatment Efficacy; Treatment Failure; treatment risk; treatment strategy; Whole Blood; ","Development of a Designer Proline-rich antimicrobial peptide Chaperone protein inhibitor (DPC) for treating sepsis","149809","ZRG1","Special Emphasis Panel ","","A1","01","","","299999",""
"10142009","R21","AI","3","N","05/21/2020","05/21/2020","06/30/2020","855","R21AI147017","SCHOOLS OF MEDICINE","PA-18-935","3R21AI147017-01S1","NIAID:87402\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","PITTSBURGH","UNITED STATES","INTERNAL MEDICINE/MEDICINE","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","Project Narrative This proposal is responsive to the Notice of Special Interest NOT-AI-20-030 regarding the urgent need for research on the 2019 novel coronavirus, SARS-CoV-2. The successful completion of our aims would lead to the identification of therapeutic avenues to prevent acute lung injury caused by SARS-CoV-2, which would have an immediate and profound impact on global public health.","1887021; ","BARRATT-BOYES, SIMON M;","SINGLETON, KENTNER L","05/21/2020","06/30/2021","2019-nCoV; Acute Lung Injury; Adult Respiratory Distress Syndrome; Alveolar; Alveolar Cell; alveolar epithelium; Alveolar Macrophages; Avian Influenza; base; Bilateral; Cadaver; Case Study; CASP1 gene; Caspase; Cell Death; cell injury; Cells; cellular targeting; Cessation of life; Cleaved cell; Clinical; Complement; Coronavirus Infections; COVID-19; cytokine; Diffuse; Disease; Disulfiram; Drug Targeting; Drug usage; Epithelial Cells; experience; Goals; Human; Immune; Immune response; Infection; Inflammation; Inflammatory; Influenza; Influenza A virus; Influenza A Virus, H5N1 Subtype; inhibitor/antagonist; Injury; Innate Immune Response; interest; interleukin-1beta-converting enzyme inhibitor; Intervention; Investigation; Laboratories; Lead; Lung; Lung Inflammation; lung injury; Measures; Mediating; Middle East Respiratory Syndrome; pandemic disease; Pathogenesis; pathogenic virus; Pathogenicity; Pathway interactions; Patients; Pharmaceutical Preparations; Pharmacology; pneumocyte; Pneumonia; Population; prevent; Process; Public Health; Research; response; Slice; Specimen; Suspensions; System; targeted treatment; Testing; Therapeutic; Tissues; tool; treatment response; Universities; Viral Pneumonia; Virus; Work; ","Blocking pyroptosis to prevent acute lung injury in SARS-CoV-2 infection","147017","","","","S1","01","66118","21284","87402",""
"9894778","R21","DA","5","N","05/18/2020","04/01/2020","03/31/2021","279","R21DA048323","","PA-18-344","5R21DA048323-02","NIDA:210000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","BOSTON","UNITED STATES","","08","073130411","US","4907701","MASSACHUSETTS GENERAL HOSPITAL","MA","021142696","In this project, we propose to characterize the EEG signatures of fentanyl in patients, in the highly controlled confines of the operating room, where fentanyl is routinely administered for general anesthesia. Our goal is to understand the relationships between EEG oscillations and the state of fentanyl-induced unconsciousness, to help develop new monitors to improve care of opioid overdose patients.","8549666; ","PURDON, PATRICK L.;","BOUGH, KRISTOPHER J","04/01/2019","03/31/2021","Absence of pain sensation; Accident and Emergency department; Accounting; Anesthesiology; Anesthetics; Arousal; Behavior; Behavioral; Biological Markers; Brain; Caring; Clinical; clinical care; clinical decision support; clinical decision-making; clinical practice; cost; density; Distress; Dose; Drug Kinetics; drug sensitivity; Drug usage; Drug user; Electroencephalogram; Fentanyl; first responder; General Anesthesia; Goals; Human; Human Resources; improved; Individual; individual patient; Intervention; Intubation; Link; Measures; Modern 1601-history; Monitor; neural circuit; neurophysiology; nociceptive response; Operating Rooms; Opioid; opioid epidemic; opioid overdose; Overdose; Patients; Pharmaceutical Preparations; pharmacodynamic model; Phase; Physicians; Physiological; Physiology; Pilot Projects; Public Health; Research; Respiration; respiratory; response; Resuscitation; Savings; Sedation procedure; Signal Transduction; source localization; Structure; synthetic opioid; Time; tool; Unconscious State; United States; Ventilatory Depression; ","A pilot study to characterize brain dynamic biomarkers of fentanyl for opioid overdose monitoring","048323","ZRG1","Special Emphasis Panel ","","","02","125000","85000","210000",""
"10039435","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI153666","OVERALL MEDICAL","PA-19-053","1R21AI153666-01","NIAID:228797\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","PORTLAND","UNITED STATES","NONE","03","096997515","US","6297007","OREGON HEALTH & SCIENCE UNIVERSITY","OR","972393098","Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with several cancers. Despite clinical advances, EBV continues to be a significant cause of morbidity in individuals with immune deficiencies and can be life-threatening for transplant patients. The proposed study will specifically examine how the anti-apoptotic EBV BHRF1 locus interacts with and impacts activity of oncogenic host microRNAs. Understanding how viral factors regulate cellular processes at the molecular level can lead to improved drug design and new treatment strategies for viral disease.","10345899; ","SKALSKY, REBECCA L;","NATARAJAN, RAMYA","05/22/2020","04/30/2022","3' Untranslated Regions; Affect; Antigens; Antineoplastic Agents; Apoptosis; Apoptotic; B-Lymphocytes; BCL2 gene; Binding Sites; Biological Assay; Biological Process; Cell physiology; Cell Proliferation; Cells; cellular engineering; Clinical; Code; Complex; Development; Disease; DNA Tumor Viruses; Drug Design; Environment; Epithelial Cells; Epstein-Barr Virus Infections; Epstein-Barr Virus latency; Exhibits; experimental study; Family member; Gene Expression; gene product; Genetic Transcription; genotoxicity; Health; Hematologic Neoplasms; Herpesviridae; Homologous Gene; Human; Human Herpesvirus 4; Immune; Immunocompromised Host; improved; In Vitro; Individual; infected B cell; Infection; insight; Knowledge; Lead; Libraries; Life; Life Cycle Stages; loss of function; Luciferases; Lymphocyte; Lytic; Malignant Neoplasms; Measures; member; MicroRNAs; miRNA expression profiling; Molecular; Monitor; Morbidity - disease rate; mutant; Mutation; nonhuman primate; Northern Blotting; novel; Oncogenic; Pathogenesis; Pilot Projects; Play; Post-Transcriptional Regulation; Process; Production; Proteins; recombinant virus; Regulation; Reporter; Resistance; RNA; Role; sensor; Shapes; Signal Transduction; Site; Small RNA; Solid Neoplasm; Testing; Transcript; Transplant Recipients; treatment strategy; Untranslated RNA; vaccine development; Viral; Viral Proteins; Virus; Virus Diseases; Virus Replication; ","Regulation of host miRNA activity by Epstein-Barr virus BHRF1","153666","VIRA","Virology - A Study Section ","","","01","152731","76066","228797",""
"10129142","R01","AI","3","N","05/20/2020","05/20/2020","05/31/2020","855","R01AI146349","SCHOOLS OF MEDICINE","PA-18-484","3R01AI146349-01S1","NIAID:4629\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","DALLAS","UNITED STATES","PEDIATRICS","30","800771545","US","578404","UT SOUTHWESTERN MEDICAL CENTER","TX","753909105","PROJECT NARRATIVE Current therapies for the neglected tropical diseases leishmaniasis, Chagas disease, and human African trypanosomiasis are ineffective and cause significant side effects in patients. Our goal is to discover and develop new drugs that kill the parasites that cause these infections. Our studies may lead to new treatments for these globally important and widespread diseases.","10594227; ","WETZEL, DAWN MARIE;","O'NEIL, MICHAEL T","06/12/2019","05/31/2024","absorption; ADME Study; Affect; Affinity; African Trypanosomiasis; Albendazole; alpha Tubulin; Ames Assay; Amphotericin; analog; Anthelmintics; Antiparasitic Agents; Antiprotozoal Agents; aqueous; benzimidazole; beta Tubulin; Binding; Bioavailable; Biological; Biological Assay; Biological Availability; Biology; Biomedical Research; Cell division; Chagas Disease; chemical property; Chemicals; Clinical; Collection; combat; Communicable Diseases; Cutaneous; Cutaneous Leishmaniasis; cytotoxic; cytotoxicity; Data; Development; Drug Kinetics; Enhancers; Evaluation; Excretory function; extracellular; Frequencies; Future; Genetic; Goals; high throughput screening; Human; human disease; improved; In Vitro; in vitro activity; in vitro testing; in vivo; indexing; Infection; inhibitor/antagonist; innovation; Institutes; Ion Channel; Kinetics; Lead; lead candidate; Leishmania; Leishmaniasis; Lesion; Life Cycle Stages; Malaria; Mammalian Cell; Medicine; Metabolic; Metabolism; Microtubules; Molecular Target; mouse model; Mus; Mutation; neglected tropical diseases; novel; novel therapeutics; Oral; overexpression; Parasite resistance; Parasites; Parasitic Diseases; pathogen; Patients; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacology Study; Phenotype; Plasma; polymerization; preclinical study; prevent; Property; Proteins; Publishing; Rattus; Research; research and development; Resistance; Resistance development; resistance mechanism; Risk; Safety; safety assessment; scaffold; screening; Series; side effect; small molecule; Solubility; Structure-Activity Relationship; synergism; targeted treatment; Testing; Therapeutic Index; Toxic effect; Trypanosoma; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis; Tubulin; Validation; Visceral Leishmaniasis; Widespread Disease; ","Targeting a New Therapy for Trypanosomatids","146349","DDR","Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section ","","S1","01","2840","1789","4629",""
"10134744","R01","AI","3","N","05/18/2020","05/18/2020","08/31/2020","855","R01AI141327","SCHOOLS OF MEDICINE","PA-20-135","3R01AI141327-02S1","NIAID:104001\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","ATLANTA","UNITED STATES","PEDIATRICS","05","066469933","US","2384501","EMORY UNIVERSITY","GA","303224250","Project Narrative Coronavirus disease 2019 (COVID-19) is an emerging global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is imposing a tremendous public health threat, with no vaccines and therapeutic agents against SARS-CoV-2 currently available. This application proposes to investigate the antiviral efficacy of 200 selected anti-SARS-CoV-2 polymerase inhibitor compounds by employing our established in vitro SARS-CoV-2 virus culture and viral assay system.","1939323 (contact); 1884100; ","KIM, BAEK  (contact); SCHINAZI, RAYMOND FELIX;","FITZGIBBON, JOSEPH E","05/18/2020","08/31/2023","2019-nCoV; alveolar type II cell; anti-viral efficacy; Antiviral Agents; Binding; Biological Assay; biosafety level 2 facility; Cell Line; Cells; Centers for Disease Control and Prevention (U.S.); Chemicals; Chemistry; Clinical; Common Cold; Coronavirus; COVID-19; Development; Disease Outbreaks; drug candidate; drug development; drug discovery; Drug Targeting; emtricitabine; Goals; Hepatitis B Virus; Hepatitis C virus; HIV; HIV-1; Human; human coronavirus; improved; In Vitro; Infection; inhibitor/antagonist; Integral Membrane Protein; Investigational Therapies; Lamivudine; Libraries; Lung; Measures; medical schools; Middle East Respiratory Syndrome; Middle East Respiratory Syndrome Coronavirus; Monitor; Monoclonal Antibodies; novel; Nucleosides; Nucleotides; pandemic disease; pathogenic virus; pediatric department; Peptidyl-Dipeptidase A; Pneumonia; Polymerase; Proteins; Public Health; receptor; Reporting; Research; Resources; Respiratory Failure; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase Inhibitor; RNA Viruses; RNA-Directed RNA Polymerase; SARS coronavirus; screening; Serine Protease; Severe Acute Respiratory Syndrome; success; Surface; System; Testing; Therapeutic; Therapeutic Agents; therapeutic candidate; Therapeutic Intervention; therapeutic target; Toxic effect; United States National Institutes of Health; Universities; Vaccines; Viral; viral RNA; Virulent; virus culture; Virus Replication; Zoonoses; ","SARS-CoV-2 polymerase inhibitor screening","141327","","","","S1","02","66667","37334","104001",""
"9921427","P30","EY","5","N","05/20/2020","04/01/2020","03/31/2021","867","P30EY008098","SCHOOLS OF MEDICINE","PAR-17-322","5P30EY008098-32","NEI:757155\","RESEARCH CENTERS","2020","NATIONAL EYE INSTITUTE","","PITTSBURGH","UNITED STATES","OPHTHALMOLOGY","18","004514360","US","2059802","UNIVERSITY OF PITTSBURGH AT PITTSBURGH","PA","152603203","NARRATIVE The Core Grant for Vision Research supports the efforts of a diverse group of vision scientists in the Pittsburgh area. The grant provides critical support to NEI-funded investigators, and it supports pilot studies that can be incorporated into new NIH/NEI R01 applications from new investigators or established investigators moving into vision research. The services and equipment provided by this grant allow our vision scientists to integrate diverse scientific approaches into their vision research projects and thereby enhance their overall impact.","9403772; ","GROSS, JEFFREY ;","LIBERMAN, ELLEN S","04/01/1997","03/31/2024","Area; Award; base; Biomechanics; Cellular biology; Clinical; Collaborations; Communicable Diseases; Communities; Complement; Core Facility; Core Grant; Cornea; data submission; Department of Defense; Development; Environment; Equipment; experience; Faculty; Faculty Recruitment; faculty support; Fostering; Foundations; Funding; Glaucoma; Goals; graduate student; Grant; Growth; Home environment; Human Resources; Image; Immunology; innovation; Institutes; International; Knowledge; Laboratories; Methodology; Natural regeneration; ocular microbiome; operation; Ophthalmology; Phase; Pilot Projects; Play; post-doctoral training; pre-doctoral; programs; Prosthesis; Qualifying; ranpirnase; recruit; Request for Proposals; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Retina; Retinal; Role; Scientist; Seeds; Services; stem cell biology; Stem cells; student training; success; Technology; Therapeutic; Trabecular meshwork structure; Training; Training Programs; undergraduate student; United States National Institutes of Health; Universities; Vision; Vision research; vision science; Visual Cortex; visual neuroscience; Work; ","Core Grant for Vision Research","008098","ZEY1","Special Emphasis Panel ","","","32","490321","266834","757155",""
"9852904","P20","GM","1","N","05/21/2020","12/01/2019","11/30/2020","","P20GM130448","","PAR-18-266","1P20GM130448-01A1","NIGMS:236388\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MANHATTAN","UNITED STATES","","01","929773554","US","4202801","KANSAS STATE UNIVERSITY","KS","665062504","Project Narrative: To best respond to emerging viruses, all potential pathogenic mechanisms must be appreciated. Inhibition/degradation of p53 and pRB are established ways that viruses can be oncogenic, but others likely exist. This project examines the mutagenic and oncogenic potential of p300 inactivation using cutaneous human papillomaviruses as a model.","10187240; ","WALLACE, NICHOLAS ALLEN;","","","","Animal Model; Attenuated; attenuation; Biochemical; BRCA1 gene; BRCA2 gene; Bypass; Cancer Etiology; cancer risk; Cell Culture Techniques; Cell Cycle; Cell Cycle Regulation; Cells; Centrosome; Characteristics; Chromosomes; chronic infection; Communicable Diseases; Complex; crosslink; Cutaneous; Data; Dependence; Disease; DNA; DNA Interstrand Crosslinking; DNA replication fork; Emerging Communicable Diseases; EP300 gene; Epidemiology; Epidermodysplasia Verruciformis; Event; experience; Exposure to; Failure; Fanconi's Anemia; FDA approved; Formulation; Frequencies; G2 Phase; Gene Expression; General Population; Genes; Genetic Materials; Genome; Genomic Instability; Goals; Growth; Human Genome; Human papilloma virus infection; Human Papilloma Virus Vaccine; Human Papillomavirus; human pathogen; Immunosuppression; Impairment; improved; Infection; Infectious Agent; inhibitor/antagonist; insight; Lead; Link; Malignant - descriptor; Malignant Neoplasms; Mitosis; Modeling; Molecular Biology; Mutation; novel; Oncogenic; pathogen; Pathogenicity; Pathway interactions; Patients; Polymerase; Post-Translational Protein Processing; pressure; prevent; Process; protein degradation; Proteins; Publishing; Regulation; Repair Complex; repaired; replication factor A; Research; Resolution; response; Retinoblastoma Protein; Risk; Risk Assessment; Role; S Phase; Signal Transduction; Skin; Skin Carcinoma; Societies; stem; Sun Exposure; Sunscreening Agents; System; Techniques; Technology; Testing; TP53 gene; transcription factor; Tropism; tumor; Tumor Suppressor Proteins; tumorigenesis; tumorigenic; ultraviolet damage; Ultraviolet Rays; UV induced; UV sensitive; Viral; Viral Genes; Viral Proteins; Virus; Virus Diseases; World Health Organization; Zoonoses; ","Cutaneous Human Papillomavirus as a Novel Model of Viral Oncogenesis","130448","ZGM1","Special Emphasis Panel ","7582","A1","01","160000","76388","","236388"
"9933892","P30","DK","5","N","05/20/2020","04/01/2020","03/31/2021","","P30DK020593","","RFA-DK-16-020","5P30DK020593-43","NIDDK:273630\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","","1878595; ","POWERS, ALVIN C;","","","","Abbreviations; Academic Medical Centers; acronyms; Advisory Committees; American; base; Beta Cell; burden of illness; Cellular biology; Clinical Research; Collaborations; Communication; Communities; Core Facility; Development; Diabetes Mellitus; Digestive System Disorders; educational atmosphere; Effectiveness; Ensure; Environment; environmental enrichment for laboratory animals; experience; Faculty; Fostering; Funding; Goals; graduate student; Human; improved; Informatics; Institutes; Interdisciplinary Study; islet; Knowledge; Leadership; Maintenance; medical schools; Medical Students; member; Metabolic; metabolic phenotype; Metabolism; Mission; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Pilot Projects; Postdoctoral Fellow; Process; Productivity; programs; Public Health; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Review Committee; Training; Training Activity; Translating; Translational Research; United States National Institutes of Health; Universities; web site; ","Administrative Core","020593","ZDK1","Special Emphasis Panel ","7645","","43","194456","79174","","273630"
"9937526","IK2","VA","5","N","05/21/2020","03/01/2020","02/28/2021","999","IK2RX002490","","RFA-RX-17-007","5IK2RX002490-03","","OTHERS","2020","Veterans Affairs","","GAINESVILLE","UNITED STATES","","03","097378632","US","481152","VETERANS HEALTH ADMINISTRATION","FL","326081135","Hundreds of thousands of Veterans seeking rehabilitation treatment for post traumatic stress disorder (PTSD) have had a mild traumatic brain injury (mTBI). The contribution of mTBI to PTSD is unclear. Unfortunately, the best treatments currently available do not fully rehabilitate the majority of Veterans with comorbid mTBI and PTSD, even when used in combination. A lack of effective treatment negatively impacts the quality of life of those Veterans who do not achieve remission or full recovery. This study will investigate the underlying relationship between cognitive and emotional brain networks that likely underlie emotional dysregulation using both behavioral and magnetic resonance measures that are negatively impacted by PTSD. The proposed investigation uses an innovative approach and will contribute new knowledge regarding the mechanisms of emotional dysregulation in this population. New treatment approaches are likely to result from a better understanding of the relationship of injury characteristics of mTBI and manifestation of PTSD.","12234461; ","LAMB, DAMON G;","","03/01/2018","02/28/2023","Affect; Amygdaloid structure; Animal Model; Back; base; Behavioral; blood oxygen level dependent; Brain; Brain region; career; Characteristics; Chronic; Cognitive; cognitive task; combat; common symptom; Communities; comorbidity; Conflict (Psychology); Data; design; Development; diagnostic biomarker; Disease; Disease remission; Disinhibition; effective therapy; emotion dysregulation; Emotional; Emotional disorder; emotional experience; emotional symptom; Emotions; Employment; Evaluation; executive function; experience; Family; frontal lobe; functional decline; Functional Magnetic Resonance Imaging; GABA Receptor; gamma-Aminobutyric Acid; Goals; Happiness; Health; Health Services Administration; High Prevalence; improved; in vivo; Individual; inhibitor/antagonist; Injury; innovation; Insula of Reil; interest; Intervention; Investigation; Knowledge; Limbic System; Literature; Magnetic Resonance; Magnetic Resonance Spectroscopy; Measurement; Measures; Mediating; Memory; mild traumatic brain injury; Military Personnel; negative affect; Neurotransmitters; Norepinephrine; Outcome; Participant; Pathology; Patient Self-Report; Patients; Pattern; Performance; personalized medicine; Pharmacotherapy; Physiological; Population; Post-Traumatic Stress Disorders; post-traumatic symptoms; Predisposition; Prefrontal Cortex; Prevalence; Quality of life; receptor; Recovery; Rehabilitation therapy; Reporting; Research; Research Training; Resources; reuptake; Role; Selective Serotonin Reuptake Inhibitor; Serotonin; service member; Short-Term Memory; Signal Transduction; Signs and Symptoms; social; social relationships; Structure; Symptoms; System; Testing; Theoretical model; therapy development; Translational Research; Treatment Efficacy; Veterans; Visual; visual stimulus; Work; ","Brain changes underlying emotional and executive alterations in TBI","002490","RRD8","Career Development Program - Panel I ","","","03","","","",""
"10072323","R21","AI","1","N","05/22/2020","05/22/2020","04/30/2021","855","R21AI154935","SCHOOLS OF MEDICINE","PA-19-053","1R21AI154935-01","NIAID:234000\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","LOS ANGELES","UNITED STATES","INTERNAL MEDICINE/MEDICINE","33","092530369","US","577505","UNIVERSITY OF CALIFORNIA LOS ANGELES","CA","900952000","RELEVANCE TO PUBLIC HEALTH The presence of anti-SSA autoantibodies in pregnant mothers associated with high risk of development of neonatal lupus in the child. This complication can be fatal or severely disabling and/or require a pacemaker in the affected children. Here we propose a new modality for the prevention of this complication through and an immune-based approach that could improve management and prognosis of this serious complication associated with the presence of anti-SSA antibodies in pregnant women.","2095921; ","LA CAVA, ANTONIO ;","JOHNSON, DAVID R","05/22/2020","04/30/2022","Adrenal Cortex Hormones; Affect; Animal Disease Models; Animal Model; Antibodies; Antibody Specificity; Antigens; Autoantibodies; base; Biological; Birth; Cardiac conduction system; Child; child bearing; Child Mortality; Clinical Management; Combined Modality Therapy; Complication; Congenital Heart Block; Cross-Sectional Studies; Data; Death Rate; Deposition; Development; diagnostic biomarker; Disease; experimental study; Fetal Heart; Fetus; Fibrosis; Future; Glucocorticoids; Goals; Half-Life; Heart; Heart Block; heart damage; Heart Transplantation; high risk; Human; Immune; Immunosuppression; Impairment; improved; improved outcome; in vivo; in vivo evaluation; Incidence; infant death; infection risk; Injury; Intervention; Intravenous Immunoglobulins; Investigation; Leptin; Life; Link; Mediating; Modality; Modification; Morbidity - disease rate; mortality; Mothers; mouse model; Mus; Neonatal lupus erythematosus; Organ; outcome forecast; Pacemakers; passive transport; Pathogenesis; Pathologic; Pathway interactions; Patients; Pharmaceutical Preparations; Placenta; Plasma; Plasmapheresis; pre-clinical; pregnant; Pregnant Women; Prevention; Production; promoter; prospective; Protocols documentation; Public Health; Ribonucleoproteins; Risk; Risk Reduction; Secondary to; seropositive; side effect; Signal Transduction; Sjogren's Syndrome; System; Systemic Lupus Erythematosus; Testing; Therapeutic Intervention; tissue injury; Tissues; Treatment Efficacy; ","Autoantibody blockade in neonatal lupus","154935","ZRG1","Special Emphasis Panel ","","","01","150000","84000","234000",""
"10133313","R01","CA","7","N","05/18/2020","04/01/2020","03/31/2021","396","R01CA218802","SCHOOLS OF MEDICINE","PA-18-590","7R01CA218802-03","NCI:376547\","Non-SBIR/STTR RPGs","2020","NATIONAL CANCER INSTITUTE","","CHICAGO","UNITED STATES","RADIATION-DIAGNOSTIC/ONCOLOGY","07","005436803","US","6144650","NORTHWESTERN UNIVERSITY AT CHICAGO","IL","606113152","The characterization of MSI2-regulated signaling will lead to better understanding of mechanisms driving lung cancer, and will support development of a biomarker for prognosis. It will also potentially help in development of future individualized treatment strategies for lung cancer patients, particularly as we evaluate whether MSI2 conditions therapeutic response to VEGFR2 and VEGF-A inhibitors, or may be valuable as a drug target.","12154958; ","BOUMBER, YANIS ;","AULT, GRACE S","04/01/2020","03/31/2023","Address; Adenocarcinoma; Affect; Alleles; angiogenesis; autocrine; Automobile Driving; base; bevacizumab; Biological Markers; cancer cell; Cancer cell line; Cancer Etiology; Cancer Model; Cancer Patient; Carboplatin; Cause of Death; cell growth; Cell Line; Cells; Cessation of life; Clinical; Clinical Trials; clinically significant; Coculture Techniques; Complement; Data; design; Development; Drug resistance; Drug Targeting; efficacy study; Endothelial Cells; Endothelial Growth Factors Receptor; Epithelial; Epithelium; experimental study; Future; Goals; Growth; Human; human tissue; Hypoxia; improved; In Vitro; in vivo; individualized medicine; inhibitor/antagonist; interest; Investigation; KDR gene; Ligands; loss of function; Lung Neoplasms; MADH3 gene; Malignant neoplasm of lung; Mesenchymal; Messenger RNA; Modeling; Molecular; Mouse Cell Line; mouse model; Mus; Neoplasm Metastasis; neoplastic cell; Non-Small-Cell Lung Carcinoma; Nonmetastatic; novel; Oncogenic; outcome forecast; overexpression; paracrine; Pathway Analysis; Pathway interactions; Patients; Phase; Phenotype; Physicians; Pilot Projects; preclinical study; Protein Array; Protein Array Analysis; Proteins; receptor; receptor expression; Regulation; Reporting; response; RNA; RNA-Binding Proteins; Role; Scientist; screening; Signal Pathway; Signal Transduction; small molecule; Specimen; Structure of parenchyma of lung; targeted treatment; Testing; Therapeutic; Tight Junctions; Time; Tissue Microarray; TP53 gene; Transcript; Transforming Growth Factor beta; Transgenic Mice; Translations; treatment response; treatment strategy; tumor; Tumor Angiogenesis; tumor growth; tumor progression; tumorigenesis; Up-Regulation; Ursidae Family; Vascular Endothelial Growth Factors; Vascularization; Work; Xenograft Model; Xenograft procedure; ","Targeting Musashi-2 (MSI2) regulation of VEGFR2/VEGF-A in lung cancer","218802","TPM","Tumor Progression and Metastasis Study Section ","","","03","238321","138226","376547",""
"10166607","I01","VA","5","N","05/17/2020","06/01/2019","05/31/2020","999","I01HX001618","","RFA-HX-14-002","5I01HX001618-05","","Non-SBIR/STTR RPGs","2020","Veterans Affairs","","ANN ARBOR","UNITED STATES","","12","096318480","US","481045","VETERANS HEALTH ADMINISTRATION","MI","481052303","This study will evaluate an intervention to help Veterans with diabetes get the most benefit from VA care and be successful at managing diabetes. The intervention aims to increase the capacity of VA primary care clinics to support the family members and friends who help Veterans with diabetes engage in their health care. This intervention is designed to be patient and family-centered ? it gives Veterans and their supporters skills and tools to take action in managing diabetes, and to work effectively with patients' VA primary care doctors and nurses. If successful, the study will establish a new approach for involving patients' supporters in VA care, in ways that could avert devastating consequences of uncontrolled diabetes. Similar methods could then be used by the VA to better support Veterans' family caregivers, and to improve health management, for Veterans with other high-risk conditions.","9802664; ","ROSLAND, ANN-MARIE ;","","06/01/2015","09/30/2020","Address; Adult; Appointment; base; Behavior; Blood Glucose; Blood Pressure; blood pressure regulation; Cardiac; cardiovascular risk factor; Cardiovascular system; care burden; Caregiver Burden; Caregivers; Caring; Characteristics; Chronically Ill; Clinic; Clinical; Complex; Complications of Diabetes Mellitus; design; diabetes management; Diabetes Mellitus; diabetes risk; Distress; Event; evidence base; Family; Family Caregiver; Family member; family support; Friends; Glucose; glucose monitor; Glycosylated hemoglobin A; Goals; Health; Health behavior; health literacy; health management; Healthcare; Healthcare Systems; Healthy Eating; healthy lifestyle; high risk; Home environment; Hyperglycemia; Hyperlipidemia; Hypertension; Hypoglycemia; improved; Intervention; intervention effect; Knowledge; Life; Lipids; Measurement; Measures; Medical; medical appointment; Medical Records; medication compliance; member; Methods; novel strategies; Nurses; Outcome; Outcome Study; Participant; Patient Care; patient safety; Patients; Play; Preparation; prevent; Primary Health Care; primary outcome; Process; Protocols documentation; Provider; Quality of Care; Randomized; Randomized Controlled Trials; randomized trial; recruit; Regimen; Reporting; Resources; Risk; Role; satisfaction; secondary outcome; Self Care; Self Efficacy; Self Management; skills; Structure; success; System; Team Nursing; Techniques; Telephone; Testing; tool; Treatment Protocols; Veterans; Visit; Work; ","Engaging Veterans and Family Supporters in PACT to Improve Diabetes Management","001618","HSR2","HSR-2 Determinants of Patient Response to Care   ","","","05","","","",""
"10142749","R01","AI","3","N","05/18/2020","05/18/2020","08/31/2020","855","R01AI137276","GRADUATE SCHOOLS","PA-18-591","3R01AI137276-02S1","NIAID:141249\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","NEW YORK","UNITED STATES","GENETICS","12","071037113","US","7056601","ROCKEFELLER UNIVERSITY","NY","100656399","Narrative In response to SARS-CoV-2 infection, antibodies are elicited, contributing to antiviral protection. However, it is likely that antibodies could also increase infection and exacerbate disease, a phenomenon termed as antibody- dependent enhancement (ADE). The proposed studies aim to characterize the capacity of anti-SARS-CoV-2 antibodies to mediate ADE, guiding the design of optimized mAbs with optimal safety profile for subsequent clinical development and use for the control of COVID-19 disease.","10675741; ","BOURNAZOS, STYLIANOS ;","WOODSON, SARA ELAINE","05/18/2020","08/31/2021","2019-nCoV; Active Immunization; Address; Antibodies; Antibody Therapy; Antibody-Dependent Enhancement; Antiviral Agents; Binding; Cells; Chiroptera; Clinical; clinical development; Coronavirus; COVID-19; cross reactivity; Dengue; design; Development; Disease; Disease susceptibility; Exhibits; Fc domain; Flavivirus; global health emergency; Human; Immunity; Immunoglobulin G; Immunologic Factors; Infection; Mediating; Middle East Respiratory Syndrome Coronavirus; Molecular; Monoclonal Antibodies; Morbidity - disease rate; mortality; pandemic disease; Passive Immunization; Patients; Predisposition; Process; public health emergency; Research; response; Role; Safety; SARS coronavirus; Severity of illness; stem; Testing; Therapeutic Intervention; transmission process; Vaccination; vaccine candidate; vaccine development; Vaccines; Variant; Virus Diseases; ","Mechanisms of antibody-dependent enhancement of SARS-CoV-2 infection","137276","","","","S1","02","83333","57916","141249",""
"9921216","U54","MD","5","N","05/18/2020","04/01/2020","03/31/2021","307","U54MD010722","","RFA-MD-15-013","5U54MD010722-05","NIMHD:58758\NHGRI:2275000\","RESEARCH CENTERS","2020","National Institute on Minority Health and Health Disparities","","NASHVILLE","UNITED STATES","","05","079917897","US","10040927","VANDERBILT UNIVERSITY MEDICAL CENTER","TN","372320011","PUBLIC HEALTH RELEVANCE    Narrative Our Center is designed to fill an important gap in disparities science by developing robust methods to enable examination of multilevel determinants that drive disparity broadly and not for a specific disease phenotype. This approach is critical because determinants of disparity are likely similar/shared and we can use findings to devise interventions that tackle determinants not simply disease risk.","3075104; 9526815; 1857623; 7182203 (contact); ","COX, NANCY J; MILLER-HUGHES, STEPHANIA T.; WEISS, ROY E; WILKINS, CONSUELO HOPKINS (contact);","RAJAPAKSE, NISHADI","05/19/2016","03/31/2021","Academic Medical Centers; Address; Adult; Adverse event; African American; Area; Asthma; Behavioral; biobank; Biological; cardiometabolic risk; Cardiovascular Diseases; Childhood; Clinical; Collaborations; Communities; Data; design; Diabetes Mellitus; Disease; disease phenotype; disorder risk; DNA; Doctor of Philosophy; Electronic Health Record; Employment; Environmental Risk Factor; Ethics; ethnic minority population; Ethnic Origin; Event; experience; Face; Faculty; fetal; Fostering; Foundations; Funding; General Population; Genetic; genomic data; genomic variation; Genomics; gestational weight gain; Growth; Health; health disparity; Health Professional; Hispanics; Human; Human Development; Hypertension; Income; Individual; individual variation; Infrastructure; Institutes; Institution; Intention; International; Intervention; Investigational Therapies; Latino; Lead; Life; Link; Lipids; Malignant Neoplasms; Medical center; medical schools; Medicine; member; Metabolic; Methods; Minority; Mississippi; Modeling; novel; Obesity; obesity in children; Pathway interactions; personalized medicine; Persons; Pharmaceutical Preparations; Pharmacotherapy; phenotypic data; Population; population health; Precision Health; precision medicine; predictive modeling; prepregnancy obesity; prevent; Prevention strategy; public health relevance; Race; racial minority; Research; Research Training; resilience; Resources; response; Risk; Safety; Sampling; Schools; Science; screening; Secure; social; Societies; Specificity; stressor; Testing; therapy outcome; trait; Transcend; treatment strategy; United States National Institutes of Health; Universities; Vulnerable Populations; ","Center of Excellence in Precision Medicine and Population Health","010722","ZMD1","Special Emphasis Panel ","","","05","1809439","524319","2333758",""
"9852900","P20","GM","1","N","05/21/2020","12/01/2019","11/30/2020","","P20GM130448","","PAR-18-266","1P20GM130448-01A1","NIGMS:286978\","RESEARCH CENTERS","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","MANHATTAN","UNITED STATES","","01","929773554","US","4202801","KANSAS STATE UNIVERSITY","KS","665062504","","7545531; ","HARDWIDGE, PHILIP ROSS;","","","","Advisory Committees; Animal Model; Area; Biochemical; Biochemistry; Bioinformatics; Biological Assay; Biology; Biomedical Research; Biophysics; Cell Separation; Centers of Research Excellence; Clustered Regularly Interspaced Short Palindromic Repeats; Collection; college; Committee Members; Communicable Diseases; Communities; Core Facility; CRISPR/Cas technology; Data; Data Set; Diagnostic; DNA sequencing; Doctor of Philosophy; Electron Microscopy; Employee; Environment; Equipment; equipment acquisition; experience; experimental study; Extramural Activities; Faculty; Financial Support; Flow Cytometry; Fluorescence Microscopy; Funding; Goals; graduate student; Growth; Image Cytometry; Imaging technology; improved; Individual; Infrastructure; innovation; instrument; Kansas; Laboratories; laser capture microdissection; Leadership; Maintenance; member; Mentors; Methodology; Modernization; Molecular; Molecular and Cellular Biology; next generation; pathogen; Pathogenesis; Pathology; Performance; Postdoctoral Fellow; programs; Research; Research Personnel; Research Project Grants; Resources; Seeds; Services; single-cell RNA sequencing; synergism; Teacher Professional Development; Techniques; Technology; Time; Training; undergraduate student; Universities; vaccine development; Veterinary Medicine; Zoonoses; ","Molecular and Cellular Biology Core","130448","ZGM1","Special Emphasis Panel ","7578","A1","01","188801","98177","","286978"
"9927712","TL1","TR","5","N","05/19/2020","05/01/2020","04/30/2021","350","TL1TR002549","SCHOOLS OF MEDICINE","PAR-15-304","5TL1TR002549-03","NCATS:585820\","TRAINING, INSTITUTIONAL","2020","NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES","","CLEVELAND","UNITED STATES","PATHOLOGY","11","077758407","US","218601","CASE WESTERN RESERVE UNIVERSITY","OH","441061712","","1888529; ","HARDING, CLIFFORD V;","DAVIS NAGEL, JOAN","05/15/2018","04/30/2023","2,4-Dinitrophenol; Address; Area; bench to bedside; Bioinformatics; Biomedical Engineering; Biomedical Research; career; Clinic; Clinical; clinical development; Clinical Research; community setting; Degree program; Dental; design; Development; Discipline of Nursing; Doctor of Philosophy; Educational Curriculum; Effectiveness; Epidemiology; Fellowship; Funding; Health; innovation; Inosine Diphosphate; Institution; Laboratories; Medical center; Mentors; Mentorship; Modeling; National Research Service Awards; novel; Nurses; Phase; Physicians; post-doctoral training; Postdoctoral Fellow; pre-doctoral; programs; public health research; Records; Research; Research Project Grants; Research Training; Residencies; Science; science teacher; Scientist; Site; skills; Stream; success; Systems Biology; TNFSF15 gene; Training; Training Activity; Training Programs; Translational Research; translational scientist; United States Department of Veterans Affairs; United States National Institutes of Health; University Hospitals; Work; Workforce Development; ","NRSA Training Core","002549","ZTR1","Special Emphasis Panel ","","","03","555188","30632","585820",""
"10126090","P30","CA","3","N","05/22/2020","05/15/2020","11/30/2020","397","P30CA023108","SCHOOLS OF MEDICINE","PAR-17-095","3P30CA023108-41S3","NCI:59200\","RESEARCH CENTERS","2020","NATIONAL CANCER INSTITUTE","","HANOVER","UNITED STATES","PEDIATRICS","02","041027822","US","2021601","DARTMOUTH COLLEGE","NH","037551421","Project Narrative Among the fifty states, New Hampshire ranks number one in the incidence of breast, esophageal, and urinary bladder cancers, the latter reflecting the association between bladder cancer and environmental arsenic exposure linked to frequent use of rural well water within the ?Granite State?. Of similar concern, Vermont ranks number one in the incidence of uterine cancer and second in the incidence of melanoma. Norris Cotton Cancer Center continues to create important new knowledge, engage our community, and influence public policy related to these and other cancers in a manner directly relevant to these unique catchment area public health needs.","1899930; ","LEACH, STEVEN D;","BELIN, PRECILLA L","08/04/1997","11/30/2024","Adopted; anticancer research; Area; Arsenic; Authorship; Biological; Breast; Cancer Biology; cancer care; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Immunology Science; cancer immunotherapy; cancer prevention; career; Caring; Catchment Area; Characteristics; Clinic; Clinical; Clinical Trials; college; Communities; Community Outreach; Continuity of Patient Care; design; Development; Education; Education and Outreach; Engineering; Entrepreneurship; Esophagus; Evaluation; experience; Faculty Recruitment; faculty research; Frequencies; Funding; Genomics; granite; Growth; health care delivery; health equity; Health Promotion; Health system; Immunology; Immunooncology; Incidence; innovation; Institution; interdisciplinary collaboration; Investigational Therapies; investigator-initiated trial; Investments; Knowledge; Lead; Leadership; Link; Malignant neoplasm of urinary bladder; Malignant Neoplasms; Medical; medical schools; melanoma; member; Mission; Molecular Epidemiology; New Hampshire; Norris Cotton Cancer Center; novel; Parents; Pathology; Patients; Phase; Population; Population Heterogeneity; Population Sciences; precision oncology; prevent; Prevention; programs; Public Health; Public Policy; Publications; Research; Research Infrastructure; Research Support; Research Training; Resource Sharing; Rural; Rural Population; Schools; Science; Site; Strategic Planning; survivorship; Therapeutic; Trace Elements; Translating; Translational Research; United States National Institutes of Health; Update; Uterine Cancer; Vermont; well water; ","Cancer Center Support Grant","023108","NCI","Subcommittee I - Transistion to Independence ","","S3","41","59200","0","59200",""
"10039237","R21","AI","1","N","05/19/2020","05/20/2020","04/30/2021","855","R21AI153588","SCHOOLS OF MEDICINE","PA-19-053","1R21AI153588-01","NIAID:245625\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES","","BALTIMORE","UNITED STATES","INTERNAL MEDICINE/MEDICINE","07","001910777","US","4134401","JOHNS HOPKINS UNIVERSITY","MD","212051832","Malaria is an infectious disease that affects hundreds of millions of people each year, killing hundreds of thousands, mostly children under the age of five. The disease is caused by a parasite that spends part of its lifespan in humans and the other part in mosquitoes. In this proposal we test genetic-based approaches for destroying the mosquito salivary gland ? an organ essential for parasite transmission ? as part of a longer-term strategy for preventing mosquitoes from spreading the disease from one person to another.","1860214; ","ANDREW, DEBORAH J;","COSTERO-SAINT DENIS, ADRIANA","05/20/2020","04/30/2022","Adult; Aedes; Affect; African Trypanosomiasis; Age; Anopheles gambiae; Automobile Driving; base; Biological Assay; Blood; Candidate Disease Gene; Cause of Death; Cells; Cessation of life; Child; Clinical; Communicable Diseases; cost; CRISPR/Cas technology; Culicidae; Dengue; Dengue Fever; Dengue Hemorrhagic Fever; Dengue Virus; Disease; disease transmission; Distant; Drops; Drosophila genus; Event; Expression Profiling; feeding; Female; Fertility; fitness; Generations; Genes; Genetic screening method; gland development; Goals; Head; Homeostasis; Human; human disease; Incidence; Individual; Insect Vectors; Insecta; Invaded; knock-down; Knock-out; Laboratories; Learning; Leishmaniasis; Life Cycle Stages; Link; Longevity; Lyme Disease; Maintenance; Malaria; malaria infection; Morphogenesis; Morphology; Mosquito-borne infectious disease; Mutation; Ocular Onchocerciasis; Organ; Outcome; Parasites; pathogen; Pathway interactions; Persons; Phenotype; Population; prevent; Publications; Reporting; RNA Interference; Role; Saliva; Salivary Glands; Specific qualifier value; Sporozoites; Testing; Time; Tissues; transcription factor; transmission process; Tube; vector mosquito; Virus; Work; ZIKA; ","Generation of transmission-compromised mosquitoes","153588","VB","Vector Biology Study Section ","","","01","150000","95625","245625",""
"9750950","R25","DA","3","N","05/18/2020","05/01/2020","04/30/2021","279","R25DA013582","","PA-18-591","3R25DA013582-19S1","NIDA:106067\","OTHER RESEARCH-RELATED","2020","NATIONAL INSTITUTE ON DRUG ABUSE","","BOSTON","UNITED STATES","","07","005492160","US","3617301","BOSTON MEDICAL CENTER","MA","021182908","PUBLIC HEALTH RELEVANCE:  The CARE Program is significant because it engages physicians in clinical research methods and equips them to identify and care for patients with or at risk for substance use disorders. The Program will continue to develop the skills of the next generation of physician substance use researchers and contribute to the dissemination of state-of-the-art clinical addiction practices.","1873784; ","SAMET, JEFFREY H.;","WILEY, TISHA R A","05/01/2001","04/30/2022","addiction; Address; alcohol and other drug; Alcohol consumption; alcohol misuse; Alcohol or Other Drugs use; Applications Grants; career; chronic pain; Clinical; clinical care; clinical development; Clinical Medicine; Clinical Research; Clinical Skills; clinically relevant; Communicable Diseases; Country; data management; Development; Drug usage; Drug Use Disorder; Education; Educational Status; Epidemic; evidence base; expectation; experience; Faculty; faculty mentor; Family Practice; Fostering; Funding; General Practitioners; Goals; Health; Hepatitis C; Hepatitis C virus; HIV; HIV/HCV; Illicit Drugs; Immersion; Immersion Investigative Technique; Internal Medicine; Internships; Literature; Medical; medical schools; medical specialties; Medical Students; Medicine; Mentors; Mentorship; National Institute of Drug Abuse; Newsletter; next generation; online community; online resource; Opioid; Overdose; Pain; Pain management; Patient Care; Patients; Physicians; prescription drug abuse; prevent; Primary Care Physician; programs; public health relevance; recruit; Reporting; Research; Research Ethics; Research Methodology; Research Personnel; Research Proposals; research study; Residencies; Risk; screening; skills; Students; Substance Addiction; Substance Use Disorder; success; Training; Training Programs; Translating; Translational Research; web site; ","Clinical Addiction Research and Education (CARE) Program","013582","ZDA1","Special Emphasis Panel ","","S1","19","98210","7857","106067",""
"9932013","R35","GM","1","N","05/20/2020","05/20/2020","04/30/2021","859","R35GM136389","SCHOOLS OF ARTS AND SCIENCES","PAR-17-094","1R35GM136389-01","NIGMS:381250\","Non-SBIR/STTR RPGs","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","SALT LAKE CITY","UNITED STATES","BIOLOGY","02","009095365","US","514002","UNIVERSITY OF UTAH","UT","841128930","Project Narrative The maintenance of chromosome integrity is critical for preventing genetic disorders and avoiding cancer. The work described in this proposal will investigate how chromosomes break, and how cells choose different options for repairing that damage. Factors that affect chromosome pairing and orderly DNA replication will be studied to determine how they act to maintain the organization of genetic material in the nucleus, an important factor for its normal function.","1881166; ","GOLIC, KENT G;","JANES, DANIEL E","05/20/2020","04/30/2025","Affect; Aneuploidy; Area; cancer cell; Cancerous; Cell Nucleus; Cell physiology; Cells; Centromere; Chromosomal Breaks; Chromosome Breakage; Chromosome Pairing; chromosome replication; Chromosome Structures; Chromosomes; daughter cell; Dicentric chromosome; DNA biosynthesis; DNA Replication Timing; Drosophila melanogaster; Euchromatin; Eukaryota; experimental study; Failure; Frequencies; Gene Expression; Genes; Genetic Diseases; Genetic Materials; Genetic Recombination; Genome; Genome Stability; Germ Cells; Health; Heterochromatin; Histones; Human; Investigation; Lead; Maintenance; male; Malignant Neoplasms; Meiosis; Mitotic Chromosome; Modeling; Mutation; Pattern; prevent; Proteins; repaired; Site; Structure; Testing; Variant; Work; Yeasts; ","Chromosome breakage, pairing and replication: impacts on cell fate and function","136389","ZRG1","Special Emphasis Panel ","","","01","250000","131250","381250",""
"9910009","F32","GM","1","N","03/05/2020","05/01/2020","04/30/2021","859","F32GM136123","ORGANIZED RESEARCH UNITS","PA-19-188","1F32GM136123-01","NIGMS:65310\","TRAINING, INDIVIDUAL","2020","NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES","","EUGENE","UNITED STATES","BIOLOGY","04","079289626; 948117312","US","6297005","UNIVERSITY OF OREGON","OR","974035219","Project Narrative Separating the signals of polygenic trait association and population structure has emerged as a major challenge for the interpretation of genome-wide association studies (GWAS). We propose to develop new simulations of populations evolving in continuous space that will allow us to rigorously benchmark existing methods of stratification control in GWAS while fully controlling the underlying demographic and selective process. We will then apply deep learning techniques to develop (1) a new method of dimensionality reduction to test as a covariate for ancestry in GWAS, and (2) a neural network that identifies genotype-phenotype connections while controlling for population structure in the sample cohort.","15901856; ","BATTEY, CHRISTOPHER J;","SAKALIAN, MICHAEL","05/01/2020","04/30/2022","Agriculture; autoencoder; base; Benchmarking; biobank; Biology; Breeding; cohort; Communities; Computer software; Computing Methodologies; Coupled; Culicidae; Data; deep learning; deep neural network; Dimensions; diverse data; DNA Sequence; Environment; Evolution; experience; Gene Frequency; Genetic; genome wide association study; genome-wide; genomic data; Genotype; Geographic Locations; Goals; Guidelines; Haplotypes; Health; Heart Diseases; Height; Human; human data; Image; image reconstruction; improved; large scale simulation; Learning; learning strategy; Linear Models; Linear Regressions; Link; Machine Learning; machine learning algorithm; Measures; Methodology; Methods; Modeling; neural network; next generation; Non-Insulin-Dependent Diabetes Mellitus; Oligogenic Traits; Output; Performance; Phenotype; Polygenic Traits; Population; Population Genetics; Population Heterogeneity; population stratification; Positioning Attribute; Process; Public Health; Risk; Running; Sampling; Signal Transduction; simulation; Spatial Distribution; statistics; Stratification; Structure; Sum; supervised learning; Techniques; Testing; tool; Training; trait; Trans-Omics for Precision Medicine; Variant; ","Computational Methods for Next-Generation GWAS","136123","ZRG1","Special Emphasis Panel ","","","01","65310","","65310",""